Primary Site >> Stomach Cancer

Gene >> TFF2

Journal: Eur J Hum Genet. 1996;4(6):308-15.
Title: Human trefoil peptides: genomic structure in 21q22.3 and coordinated expression.
Author: Gott, P|Beck, S|Machado, J C|Carneiro, F|Schmitt, H|Blin, N
PMID: 9043862
Journal: FEBS Lett. 1998 Nov 13;439(1-2):180-4.
Title: Osmotic changes and ethanol modify TFF gene expression in gastrointestinal cell lines.
Author: Ludeking, A|Fegert, P|Blin, N|Gott, P
PMID: 9849902
Journal: Hum Hered. 1999 Jan;49(1):45-7.
Title: Variable distribution of TFF2 (Spasmolysin) alleles in Europeans does not indicate predisposition to gastric cancer.
Author: dos Santos Silva, E|Kayademir, T|Regateiro, F|Machado, J C|Savas, S|Dobosz, T|Blin, N|Gott, P
PMID: 9858857
Journal: J Pathol. 2000 Mar;190(4):437-43.
Title: Gastric carcinoma exhibits distinct types of cell differentiation: an immunohistochemical study of trefoil peptides (TFF1 and TFF2) and mucins (MUC1, MUC2, MUC5AC, and MUC6).
Author: Machado, J C|Nogueira, A M|Carneiro, F|Reis, C A|Sobrinho-Simoes, M
PMID: 10699992
Journal: FEBS Lett. 2001 Jan 19;488(3):206-10.
Title: Aspirin promotes TFF2 gene activation in human gastric cancer cell lines.
Author: Azarschab, P|Al-Azzeh, E|Kornberger, W|Gott, P
PMID: 11163773
Journal: Int J Oncol. 2002 Sep;21(3):655-9.
Title: Expression of TFF1, TFF2 and TFF3 in gastric cancer.
Author: Kirikoshi, Hiroyuki|Katoh, Masaru
PMID: 12168114
Journal: J Pathol. 2002 Aug;197(5):582-8.
Title: Expression of trefoil peptides (TFF1, TFF2, and TFF3) in gastric carcinomas, intestinal metaplasia, and non-neoplastic gastric tissues.
Author: Leung, Wai K|Yu, Jun|Chan, Francis K L|To, Ka F|Chan, Michael W Y|Ebert, M P A|Ng, Enders K W|Chung, S C Sydney|Malfertheiner, Peter|Sung, Joseph J Y
PMID: 12210076
Journal: World J Gastroenterol. 2003 May;9(5):910-4.
Title: Expression of TFF2 and Helicobacter pylori infection in carcinogenesis of gastric mucosa.
Author: Hu, Guo-Yong|Yu, Bao-Ping|Dong, Wei-Guo|Li, Mu-Qi|Yu, Jie-Ping|Luo, He-Sheng|Rang, Zong-Xue
PMID: 12717829
Journal: Int J Mol Med. 2003 Jul;12(1):3-9.
Title: Trefoil factors and human gastric cancer (review).
Author: Katoh, Masaru
PMID: 12792801
Journal: Lab Invest. 2003 Sep;83(9):1343-52.
Title: Expression of cytoplasmic TFF2 is a marker of tumor metastasis and negative prognostic factor in gastric cancer.
Author: Dhar, Dipok Kumar|Wang, Timothy C|Maruyama, Riruke|Udagawa, Jun|Kubota, Hirofumi|Fuji, Toshiyuki|Tachibana, Mitsuo|Ono, Takashi|Otani, Hiroki|Nagasue, Naofumi
PMID: 13679442
Journal: Biochem Biophys Res Commun. 2004 Jan 23;313(4):931-7.
Title: Highly specific marker genes for detecting minimal gastric cancer cells in cytology negative peritoneal washings.
Author: Mori, Kazuhiko|Aoyagi, Kazuhiko|Ueda, Tetsuya|Danjoh, Inaho|Tsubosa, Yasuhiro|Yanagihara, Kazuyoshi|Matsuno, Yoshihiro|Sasako, Mitsuru|Sakamoto, Hiromi|Mafune, Ken ichi|Kaminishi, Michio|Yoshida, Teruhiko|Terada, Masaaki|Sasaki, Hiroki
PMID: 14706632
Journal: Zhonghua Nei Ke Za Zhi. 2004 Mar;43(3):195-7.
Title: [The expression of trefoil factor 1 and trefoil factor 2 in gastric cancer and precancer].
Author: Shi, Shu-qing|Cai, Jian-ting
PMID: 15059374
Journal: Virchows Arch. 2004 Jun;444(6):536-41. Epub 2004 Apr 8.
Title: Differentiation pathways in duodenal and ampullary carcinomas: a comparative study on mucin and trefoil peptide expression, including gastric and colon carcinomas.
Author: Gurbuz, Yesim|Kloppel, Gunter
PMID: 15071739
Journal: Peptides. 2004 May;25(5):839-47.
Title: Characterization of a CCAAT-enhancer element of trefoil factor family 2 (TFF2) promoter in MCF-7 cells.
Author: Chi, Alfred L|Lim, SeonHee|Wang, Timothy C
PMID: 15177880
Journal: Aliment Pharmacol Ther. 2004 Jul;20 Suppl 1:171-6.
Title: Indometacin up-regulates TFF2 expression in gastric epithelial cells.
Author: Koitabashi, A|Shimada, T|Fujii, Y|Hashimoto, T|Hosaka, K|Tabei, K|Namatame, T|Yoneda, M|Hiraishi, H|Terano, A
PMID: 15298624
Journal: Clin Cancer Res. 2005 Sep 15;11(18):6472-8.
Title: Expression of trefoil factor family members correlates with patient prognosis and neoangiogenesis.
Author: Dhar, Dipok Kumar|Wang, Timothy C|Tabara, Hideki|Tonomoto, Yasuhito|Maruyama, Riruke|Tachibana, Mitsuo|Kubota, Hirofumi|Nagasue, Naofumi
PMID: 16166422
Journal: Bull Cancer. 2005 Sep;92(9):773-81.
Title: [Trefoil factor 1 (pS2/TFF1), a peptide with numerous functions].
Author: Mathelin, Carole|Tomasetto, Catherine|Rio, Marie-Christine
PMID: 16203267
Journal: Gastroenterology. 2005 Apr;128(4):935-45.
Title: Loss of Klf4 in mice causes altered proliferation and differentiation and precancerous changes in the adult stomach.
Author: Katz, Jonathan P|Perreault, Nathalie|Goldstein, Bree G|Actman, Lori|McNally, Sara R|Silberg, Debra G|Furth, Emma E|Kaestner, Klaus H
PMID: 15825076
Journal: Lab Invest. 2005 May;85(5):702-15.
Title: Interferon gamma induction of gastric mucous neck cell hypertrophy.
Author: Kang, Weiqun|Rathinavelu, Sivaprakash|Samuelson, Linda C|Merchant, Juanita L
PMID: 15765119
Journal: World J Gastroenterol. 2006 May 21;12(19):3119-22.
Title: Expression of trefoil factors 1 and 2 in precancerous condition and gastric cancer.
Author: Shi, Shu-Qing|Cai, Jian-Ting|Yang, Jian-Ming
PMID: 16718800
Journal: Am J Physiol Gastrointest Liver Physiol. 2007 Jun;292(6):G1726-37. Epub 2007 Mar
Title: Gastrin regulates the TFF2 promoter through gastrin-responsive cis-acting elements and multiple signaling pathways.
Author: Tu, Shuiping|Chi, Alfred L|Lim, Seonhee|Cui, Guanglin|Dubeykovskaya, Zina|Ai, Wandong|Fleming, John V|Takaishi, Shigeo|Wang, Timothy C
PMID: 17332476
Journal: Cell Physiol Biochem. 2007;20(1-4):193-204.
Title: Cytokine regulation of the trefoil factor family binding protein GKN2 (GDDR/TFIZ1/blottin) in human gastrointestinal epithelial cells.
Author: Baus-Loncar, Mirela|Lubka, Maria|Pusch, Carsten M|Otto, William R|Poulsom, Richard|Blin, Nikolaus
PMID: 17595528
Journal: Lab Invest. 2007 Dec;87(12):1265-76.
Title: Emergence of spasmolytic polypeptide-expressing metaplasia in Mongolian gerbils infected with Helicobacter pylori.
Author: Yoshizawa, Nao|Takenaka, Yoshiharu|Yamaguchi, Hirokazu|Tetsuya, Tsukamoto|Tanaka, Harunari|Tatematsu, Masae|Nomura, Sachiyo|Goldenring, James R|Kaminishi, Michio
PMID: 18004396
Journal: Gastroenterology. 2008 Feb;134(2):511-22.
Title: A molecular signature of gastric metaplasia arising in response to acute parietal cell loss.
Author: Nozaki, Koji|Ogawa, Masako|Williams, Janice A|Lafleur, Bonnie J|Ng, Vivian|Drapkin, Ronny I|Mills, Jason C|Konieczny, Stephen F|Nomura, Sachiyo|Goldenring, James R
PMID: 18242217
Journal: Dig Liver Dis. 2008 Jul;40(7):510-22.
Title: Biology of intestinal metaplasia in 2008: more than a simple phenotypic alteration.
Author: Gutierrez-Gonzalez, L|Wright, N A
PMID: 18400571
Journal: Biochem Biophys Res Commun. 2008 Nov 21;376(3):573-7.
Title: Induction of follistatin precedes gastric transformation in gastrin deficient mice.
Author: Kang, Weiqun|Saqui-Salces, Milena|Zavros, Yana|Merchant, Juanita L
PMID: 18804092
Journal: Scand J Gastroenterol. 2008 Jan;43(1):25-33.
Title: Quantitative analysis of the effect of Helicobacter pylori on the expressions of SOX2, CDX2, MUC2, MUC5AC, MUC6, TFF1, TFF2, and TFF3 mRNAs in human gastric carcinoma cells.
Author: Matsuda, Kazuyuki|Yamauchi, Kazuyoshi|Matsumoto, Takehisa|Sano, Kenji|Yamaoka, Yoshio|Ota, Hiroyoshi
PMID: 18938748
Journal: Int J Biochem Cell Biol. 2009 Mar;41(3):632-40.
Title: The trefoil factor interacting protein TFIZ1 binds the trefoil protein TFF1 preferentially in normal gastric mucosal cells but the co-expression of these proteins is deregulated in gastric cancer.
Author: May, Felicity E B|Griffin, S Michael|Westley, Bruce R
PMID: 18722547
Journal: J Biol Chem. 2009 Feb 6;284(6):3650-62.
Title: Secreted trefoil factor 2 activates the CXCR4 receptor in epithelial and lymphocytic cancer cell lines.
Author: Dubeykovskaya, Zinaida|Dubeykovskiy, Alexander|Solal-Cohen, Joel|Wang, Timothy C
PMID: 19064997
Journal: Am J Physiol Gastrointest Liver Physiol. 2009 Aug;297(2):G385-96.
Title: p53 inhibition of AP1-dependent TFF2 expression induces apoptosis and inhibits cell migration in gastric cancer cells.
Author: Tu, Shui Ping|Chi, Alfred L|Ai, Walden|Takaishi, Shigeo|Dubeykovskaya, Zina|Quante, Michael|Fox, James G|Wang, Timothy C
PMID: 19541923
Journal: Gastroenterology. 2010 Dec;139(6):2005-17.
Title: Helicobacter pylori infection promotes methylation and silencing of trefoil factor 2, leading to gastric tumor development in mice and humans.
Author: Peterson, Anthony J|Menheniott, Trevelyan R|O'Connor, Louise|Walduck, Anna K|Fox, James G|Kawakami, Kazuyuki|Minamoto, Toshinari|Ong, Eng Kok|Wang, Timothy C|Judd, Louise M|Giraud, Andrew S
PMID: 20801119
Journal: PLoS One. 2010 Jul 6;5(7):e11451.
Title: Targeted deletion of Kcne2 causes gastritis cystica profunda and gastric neoplasia.
Author: Roepke, Torsten K|Purtell, Kerry|King, Elizabeth C|La Perle, Krista M D|Lerner, Daniel J|Abbott, Geoffrey W
PMID: 20625512
Journal: Gastroenterology. 2010 May;138(5):1823-35.
Title: A novel gastrokine, Gkn3, marks gastric atrophy and shows evidence of adaptive gene loss in humans.
Author: Menheniott, Trevelyan R|Peterson, Anthony J|O'Connor, Louise|Lee, Kai Syin|Kalantzis, Anastasia|Kondova, Ivanela|Bontrop, Ronald E|Bell, Katrina M|Giraud, Andrew S
PMID: 20138039
Journal: Exp Mol Pathol. 2011 Apr;90(2):201-9.
Title: Gene expression changes in patient-matched gastric normal mucosa, adenomas, and carcinomas.
Author: Kim, Hyunki|Eun, Jung Woo|Lee, Hanna|Nam, Suk Woo|Rhee, Hwanseok|Koh, Kwi Hye|Kim, Hoguen
PMID: 21185829
Journal: J Gastroenterol. 2011 Jun;46(6):736-45.
Title: The combination of serum trefoil factor 3 and pepsinogen testing is a valid non-endoscopic biomarker for predicting the presence of gastric cancer: a new marker for gastric cancer risk.
Author: Kaise, Mitsuru|Miwa, Jun|Tashiro, Jun|Ohmoto, Yasukazu|Morimoto, Shingo|Kato, Masayuki|Urashima, Mitsuyoshi|Ikegami, Masahiro|Tajiri, Hisao
PMID: 21455714
Journal: J Gastroenterol. 2011 Jul;46(7):855-65.
Title: Current molecular markers for gastric progenitor cells and gastric cancer stem cells.
Author: Qiao, Xiaotan T|Gumucio, Deborah L
PMID: 21626457
Journal: Gastroenterology. 2011 Sep;141(3):837-845.e1-7.
Title: Tests for serum levels of trefoil factor family proteins can improve gastric cancer screening.
Author: Aikou, Susumu|Ohmoto, Yasukazu|Gunji, Toshiaki|Matsuhashi, Nobuyuki|Ohtsu, Hiroshi|Miura, Hirona|Kubota, Kensuke|Yamagata, Yukinori|Seto, Yasuyuki|Nakajima, Atsushi|Goldenring, James R|Kaminishi, Michio|Nomura, Sachiyo
PMID: 21699780
Journal: Gut Pathog. 2012 Dec 8;4(1):18.
Title: Helicobacter pylori infection induced gastric cancer; advance in gastric stem cell research and the remaining challenges.
Author: Ding, Song-Ze|Zheng, Peng-Yuan
PMID: 23217022
Journal: Curr Med Chem. 2012;19(35):5975-83.
Title: Stem cells, self-renewal and cancer of the gastric epithelium.
Author: Hoffmann, Werner
PMID: 22963573
Journal: Lab Invest. 2012 Jun;92(6):883-95.
Title: Gastric tumor development in Smad3-deficient mice initiates from forestomach/glandular transition zone along the lesser curvature.
Author: Nam, Ki Taek|O'Neal, Ryan|Lee, Yeo Song|Lee, Yong Chan|Coffey, Robert J|Goldenring, James R
PMID: 22411066
Journal: Jpn J Clin Oncol. 2012 Feb;42(2):148-52.
Title: Analysis for the combination expression of CK20, FABP1 and MUC2 is sensitive for the prediction of peritoneal recurrence in gastric cancer.
Author: Satoh, Yumiko|Mori, Kazuhiko|Kitano, Kentaro|Kitayama, Joji|Yokota, Hiromitsu|Sasaki, Hiroki|Uozaki, Hiroshi|Fukayama, Masashi|Seto, Yasuhiro|Nagawa, Hirokazu|Yatomi, Yutaka|Takai, Daiya
PMID: 22172348
Journal: Gastric Cancer. 2013 Jul;16(3):329-37.
Title: Influence of Helicobacter pylori status and eradication on the serum levels of trefoil factors and pepsinogen test: serum trefoil factor 3 is a stable biomarker.
Author: Kaise, Mitsuru|Miwa, Jun|Fujimoto, Ai|Tashiro, Jun|Tagami, Daisuke|Sano, Hiromi|Ohmoto, Yasukazu
PMID: 22907485
Journal: Int J Med Sci. 2013;10(2):133-40.
Title: Reduced expression of TFF1 and increased expression of TFF3 in gastric cancer: correlation with clinicopathological parameters and prognosis.
Author: Im, Soyoung|Yoo, Changyoung|Jung, Ji-Han|Choi, Hyun Joo|Yoo, Jinyoung|Kang, Chang Suk
PMID: 23329884
Journal: Gene. 2013 Oct 15;529(1):104-12.
Title: Promoter polymorphisms in trefoil factor 2 and trefoil factor 3 genes and susceptibility to gastric cancer and atrophic gastritis among Chinese population.
Author: Xu, Qian|Chen, Mo-Ye|He, Cai-Yun|Sun, Li-Ping|Yuan, Yuan
PMID: 23933418
Journal: PLoS One. 2013 Nov 13;8(11):e79455.
Title: Copper promotes TFF1-mediated Helicobacter pylori colonization.
Author: Montefusco, Sandro|Esposito, Roberta|D'Andrea, Luca|Monti, Maria Chiara|Dunne, Ciara|Dolan, Brendan|Tosco, Alessandra|Marzullo, Liberato|Clyne, Marguerite
PMID: 24236136
Journal: BMC Gastroenterol. 2014 Apr 11;14:74.
Title: Serum trefoil factor 3 is a promising non-invasive biomarker for gastric cancer screening: a monocentric cohort study in China.
Author: Huang, Zhigang|Zhang, Xie|Lu, Hongna|Wu, Lina|Wang, Danping|Zhang, Qiubo|Ding, Huaxin
PMID: 24720760
Journal: J Biol Chem. 2014 Oct 3;289(40):27363-75.
Title: Human trefoil factor 2 is a lectin that binds alpha-GlcNAc-capped mucin glycans with antibiotic activity against Helicobacter pylori.
Author: Hanisch, Franz-Georg|Bonar, David|Schloerer, Nils|Schroten, Horst
PMID: 25124036
Journal: Infect Immun. 2014 Aug;82(8):3227-39.
Title: Gastric de novo Muc13 expression and spasmolytic polypeptide-expressing metaplasia during Helicobacter heilmannii infection.
Author: Liu, Cheng|Smet, Annemieke|Blaecher, Caroline|Flahou, Bram|Ducatelle, Richard|Linden, Sara|Haesebrouck, Freddy
PMID: 24866791
Journal: Dig Dis Sci. 2014 Jul;59(7):1428-35.
Title: Piezo1 is as a novel trefoil factor family 1 binding protein that promotes gastric cancer cell mobility in vitro.
Author: Yang, Xiao-Ning|Lu, Ya-Pi|Liu, Jing-Jing|Huang, Jian-Kun|Liu, Yun-Peng|Xiao, Chuan-Xing|Jazag, Amarsanaa|Ren, Jian-Lin|Guleng, Bayasi
PMID: 24798994
Journal: Oncol Lett. 2014 May;7(5):1525-1531.
Title: Promoter hypermethylation and downregulation of trefoil factor 2 in human gastric cancer.
Author: Jiang, Ping|Yu, Guoyu|Zhang, Yong|Xiang, Yang|Zhu, Zhu|Feng, Weiyang|Lee, Wenhui|Zhang, Yun
PMID: 24765170
Journal: Cancer Prev Res (Phila). 2014 Jun;7(6):585-95.
Title: Slow overmethylation of housekeeping genes in the body mucosa is associated with the risk for gastric cancer.
Author: Oh, Jung-Hwan|Rhyu, Mun-Gan|Jung, Sung-Hoon|Choi, Sang-Wook|Kim, Suk-Il|Hong, Seung-Jin
PMID: 24654229
Journal: Tumour Biol. 2014 May;35(5):4199-207.
Title: Gastrokine-2 is downregulated in gastric cancer and its restoration suppresses gastric tumorigenesis and cancer metastasis.
Author: Dai, Jin|Zhang, Ning|Wang, Jinhui|Chen, Minhu|Chen, Jie
PMID: 24408014
Journal: Hum Pathol. 2015 May;46(5):643-56.
Title: Gastric-type expression signature in serrated pathway-associated colorectal tumors.
Author: Kim, Jung Ho|Kim, Kyung-Ju|Rhee, Ye-Young|Bae, Jeong Mo|Cho, Nam-Yun|Lee, Hye Seung|Kang, Gyeong Hoon
PMID: 25704805
Journal: PLoS One. 2015 Apr 13;10(4):e0122678.
Title: Increased expression of protease-activated receptor 4 and Trefoil factor 2 in human colorectal cancer.
Author: Yu, Guoyu|Jiang, Ping|Xiang, Yang|Zhang, Yong|Zhu, Zhu|Zhang, Chuanrao|Lee, Siman|Lee, Wenhui|Zhang, Yun
PMID: 25876034
Journal: J Biomed Sci. 2015 Feb 21;22:16.
Title: Genomic single nucleotide polymorphisms in the offspring of gastric cancer patients predispose to spasmolytic polypeptide-expressing metaplasia after H. pylori infection.
Author: Tsai, Yu-Ching|Hsiao, Wei-Hsin|Lin, Sheng-Hsiang|Yang, Hsiao-Bai|Cheng, Hsiu-Chi|Chang, Wei-Lun|Lu, Cheng-Chan|Sheu, Bor-Shyang
PMID: 25884934
Journal: J Korean Med Sci. 2015 Aug;30(8):1035-41.
Title: Association between Promoter Polymorphisms of TFF1, TFF2, and TFF3 and the Risk of Gastric and Diffuse Gastric Cancers in a Korean Population.
Author: Jin, Eun-Heui|Lee, Sang-Il|Kim, JaeWoo|Seo, Eun Young|Lee, Su Yel|Hur, Gang Min|Shin, Sanghee|Hong, Jang Hee
PMID: 26240479
Journal: Clin Chim Acta. 2015 Oct 23;450:127-34.
Title: Trefoil factors: Gastrointestinal-specific proteins associated with gastric cancer.
Author: Xiao, Ping|Ling, Hui|Lan, Gang|Liu, Jiao|Hu, Haobin|Yang, Ruirui
PMID: 26265233
Journal: Gut. 2016 Jun;65(6):914-24.
Title: miR-30-HNF4gamma and miR-194-NR2F2 regulatory networks contribute to the upregulation of metaplasia markers in the stomach.
Author: Sousa, Josane F|Nam, Ki Taek|Petersen, Christine P|Lee, Hyuk-Joon|Yang, Han-Kwang|Kim, Woo Ho|Goldenring, James R
PMID: 25800782
Journal: Int J Mol Sci. 2016 Sep 2;17(9). pii: ijms17091467.
Title: Aberrant JAK/STAT Signaling Suppresses TFF1 and TFF2 through Epigenetic Silencing of GATA6 in Gastric Cancer.
Author: Wu, Cheng-Shyong|Wei, Kuo-Liang|Chou, Jian-Liang|Lu, Chung-Kuang|Hsieh, Ching-Chuan|Lin, Jora M J|Deng, Yi-Fang|Hsu, Wan-Ting|Wang, Hui-Min David|Leung, Chung-Hang|Ma, Dik-Lung|Li, Chin|Chan, Michael W Y
PMID: 27598141
Journal: Int J Mol Med. 2016 Nov;38(5):1474-1480.
Title: Trefoil factor family 2 expression inhibits gastric cancer cell growth and invasion in vitro via interactions with the transcription factor Sp3.
Author: Cai, Yiling|Yi, Mengting|Chen, Dajun|Liu, Jingjing|Guleng, Bayasi|Ren, Jianlin|Shi, Huaxiu
PMID: 27668303
Journal: Helicobacter. 2017 Feb;22(1).
Title: Serum Level of Trefoil Factor 2 can Predict the Extent of Gastric Spasmolytic Polypeptide-Expressing Metaplasia in the H. pylori-Infected Gastric Cancer Relatives.
Author: Kuo, Hsin-Yu|Chang, Wei-Lun|Yeh, Yi-Chun|Tsai, Yu-Ching|Wu, Chung-Tai|Cheng, Hsiu-Chi|Yang, Hsiao-Bai|Lu, Cheng-Chang|Sheu, Bor-Shyang
PMID: 27220894
Journal: Am J Transl Res. 2017 Jul 15;9(7):3399-3410. eCollection 2017.
Title: Anti-tumor efficacy evaluation of a novel monoclonal antibody targeting neutral amino acid transporter ASCT2 using patient-derived xenograft mouse models of gastric cancer.
Author: Kasai, Noriyuki|Sasakawa, Aya|Hosomi, Kenta|Poh, Tze Wei|Chua, Bernadette Lynn|Yong, Wei Peng|So, Jimmy|Chan, Shing Leng|Soong, Richie|Kono, Koji|Ishii, Toshihiko|Yamano, Kazuya
PMID: 28804556