Primary Site >> Stomach Cancer
Gene >> TFF2
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Ref: Human trefoil peptides: genomic structure in 21q22.3 and coordinated expression. PMID: 9043862 |
Ref: Osmotic changes and ethanol modify TFF gene expression in gastrointestinal cell lines. PMID: 9849902 |
Ref: Variable distribution of TFF2 (Spasmolysin) alleles in Europeans does not indicate predisposition to gastric cancer. PMID: 9858857 |
Ref: Gastric carcinoma exhibits distinct types of cell differentiation: an immunohistochemical study of trefoil peptides (TFF1 and TFF2) and mucins (MUC1, MUC2, MUC5AC, and MUC6). PMID: 10699992 |
Ref: Aspirin promotes TFF2 gene activation in human gastric cancer cell lines. PMID: 11163773 |
Ref: Expression of TFF1, TFF2 and TFF3 in gastric cancer. PMID: 12168114 Ref: Expression of trefoil peptides (TFF1, TFF2, and TFF3) in gastric carcinomas, intestinal metaplasia, and non-neoplastic gastric tissues. PMID: 12210076 |
Ref: Expression of TFF2 and Helicobacter pylori infection in carcinogenesis of gastric mucosa. PMID: 12717829 Ref: Trefoil factors and human gastric cancer (review). PMID: 12792801 Ref: Expression of cytoplasmic TFF2 is a marker of tumor metastasis and negative prognostic factor in gastric cancer. PMID: 13679442 |
Ref: Highly specific marker genes for detecting minimal gastric cancer cells in cytology negative peritoneal washings. PMID: 14706632 Ref: [The expression of trefoil factor 1 and trefoil factor 2 in gastric cancer and precancer]. PMID: 15059374 Ref: Differentiation pathways in duodenal and ampullary carcinomas: a comparative study on mucin and trefoil peptide expression, including gastric and colon carcinomas. PMID: 15071739 Ref: Characterization of a CCAAT-enhancer element of trefoil factor family 2 (TFF2) promoter in MCF-7 cells. PMID: 15177880 Ref: Indometacin up-regulates TFF2 expression in gastric epithelial cells. PMID: 15298624 |
Ref: Interferon gamma induction of gastric mucous neck cell hypertrophy. PMID: 15765119 Ref: Loss of Klf4 in mice causes altered proliferation and differentiation and precancerous changes in the adult stomach. PMID: 15825076 Ref: Expression of trefoil factor family members correlates with patient prognosis and neoangiogenesis. PMID: 16166422 Ref: [Trefoil factor 1 (pS2/TFF1), a peptide with numerous functions]. PMID: 16203267 |
Ref: Expression of trefoil factors 1 and 2 in precancerous condition and gastric cancer. PMID: 16718800 |
Ref: Gastrin regulates the TFF2 promoter through gastrin-responsive cis-acting elements and multiple signaling pathways. PMID: 17332476 Ref: Cytokine regulation of the trefoil factor family binding protein GKN2 (GDDR/TFIZ1/blottin) in human gastrointestinal epithelial cells. PMID: 17595528 Ref: Emergence of spasmolytic polypeptide-expressing metaplasia in Mongolian gerbils infected with Helicobacter pylori. PMID: 18004396 |
Ref: A molecular signature of gastric metaplasia arising in response to acute parietal cell loss. PMID: 18242217 Ref: Biology of intestinal metaplasia in 2008: more than a simple phenotypic alteration. PMID: 18400571 Ref: Induction of follistatin precedes gastric transformation in gastrin deficient mice. PMID: 18804092 Ref: Quantitative analysis of the effect of Helicobacter pylori on the expressions of SOX2, CDX2, MUC2, MUC5AC, MUC6, TFF1, TFF2, and TFF3 mRNAs in human gastric carcinoma cells. PMID: 18938748 |
Ref: The trefoil factor interacting protein TFIZ1 binds the trefoil protein TFF1 preferentially in normal gastric mucosal cells but the co-expression of these proteins is deregulated in gastric cancer. PMID: 18722547 Ref: Secreted trefoil factor 2 activates the CXCR4 receptor in epithelial and lymphocytic cancer cell lines. PMID: 19064997 Ref: p53 inhibition of AP1-dependent TFF2 expression induces apoptosis and inhibits cell migration in gastric cancer cells. PMID: 19541923 |
Ref: A novel gastrokine, Gkn3, marks gastric atrophy and shows evidence of adaptive gene loss in humans. PMID: 20138039 Ref: Targeted deletion of Kcne2 causes gastritis cystica profunda and gastric neoplasia. PMID: 20625512 Ref: Helicobacter pylori infection promotes methylation and silencing of trefoil factor 2, leading to gastric tumor development in mice and humans. PMID: 20801119 |
Ref: Gene expression changes in patient-matched gastric normal mucosa, adenomas, and carcinomas. PMID: 21185829 Ref: The combination of serum trefoil factor 3 and pepsinogen testing is a valid non-endoscopic biomarker for predicting the presence of gastric cancer: a new marker for gastric cancer risk. PMID: 21455714 Ref: Current molecular markers for gastric progenitor cells and gastric cancer stem cells. PMID: 21626457 Ref: Tests for serum levels of trefoil factor family proteins can improve gastric cancer screening. PMID: 21699780 |
Ref: Analysis for the combination expression of CK20, FABP1 and MUC2 is sensitive for the prediction of peritoneal recurrence in gastric cancer. PMID: 22172348 Ref: Gastric tumor development in Smad3-deficient mice initiates from forestomach/glandular transition zone along the lesser curvature. PMID: 22411066 Ref: Stem cells, self-renewal and cancer of the gastric epithelium. PMID: 22963573 Ref: Helicobacter pylori infection induced gastric cancer; advance in gastric stem cell research and the remaining challenges. PMID: 23217022 |
Ref: Influence of Helicobacter pylori status and eradication on the serum levels of trefoil factors and pepsinogen test: serum trefoil factor 3 is a stable biomarker. PMID: 22907485 Ref: Reduced expression of TFF1 and increased expression of TFF3 in gastric cancer: correlation with clinicopathological parameters and prognosis. PMID: 23329884 Ref: Promoter polymorphisms in trefoil factor 2 and trefoil factor 3 genes and susceptibility to gastric cancer and atrophic gastritis among Chinese population. PMID: 23933418 Ref: Copper promotes TFF1-mediated Helicobacter pylori colonization. PMID: 24236136 |
Ref: Gastrokine-2 is downregulated in gastric cancer and its restoration suppresses gastric tumorigenesis and cancer metastasis. PMID: 24408014 Ref: Slow overmethylation of housekeeping genes in the body mucosa is associated with the risk for gastric cancer. PMID: 24654229 Ref: Serum trefoil factor 3 is a promising non-invasive biomarker for gastric cancer screening: a monocentric cohort study in China. PMID: 24720760 Ref: Promoter hypermethylation and downregulation of trefoil factor 2 in human gastric cancer. PMID: 24765170 Ref: Piezo1 is as a novel trefoil factor family 1 binding protein that promotes gastric cancer cell mobility in vitro. PMID: 24798994 Ref: Gastric de novo Muc13 expression and spasmolytic polypeptide-expressing metaplasia during Helicobacter heilmannii infection. PMID: 24866791 Ref: Human trefoil factor 2 is a lectin that binds alpha-GlcNAc-capped mucin glycans with antibiotic activity against Helicobacter pylori. PMID: 25124036 |
Ref: Gastric-type expression signature in serrated pathway-associated colorectal tumors. PMID: 25704805 Ref: Increased expression of protease-activated receptor 4 and Trefoil factor 2 in human colorectal cancer. PMID: 25876034 Ref: Genomic single nucleotide polymorphisms in the offspring of gastric cancer patients predispose to spasmolytic polypeptide-expressing metaplasia after H. pylori infection. PMID: 25884934 Ref: Association between Promoter Polymorphisms of TFF1, TFF2, and TFF3 and the Risk of Gastric and Diffuse Gastric Cancers in a Korean Population. PMID: 26240479 Ref: Trefoil factors: Gastrointestinal-specific proteins associated with gastric cancer. PMID: 26265233 |
Ref: miR-30-HNF4gamma and miR-194-NR2F2 regulatory networks contribute to the upregulation of metaplasia markers in the stomach. PMID: 25800782 Ref: Aberrant JAK/STAT Signaling Suppresses TFF1 and TFF2 through Epigenetic Silencing of GATA6 in Gastric Cancer. PMID: 27598141 Ref: Trefoil factor family 2 expression inhibits gastric cancer cell growth and invasion in vitro via interactions with the transcription factor Sp3. PMID: 27668303 |
Ref: Serum Level of Trefoil Factor 2 can Predict the Extent of Gastric Spasmolytic Polypeptide-Expressing Metaplasia in the H. pylori-Infected Gastric Cancer Relatives. PMID: 27220894 Ref: Anti-tumor efficacy evaluation of a novel monoclonal antibody targeting neutral amino acid transporter ASCT2 using patient-derived xenograft mouse models of gastric cancer. PMID: 28804556 |