Primary Site >> Colorectal Cancer

Gene >> TAOK2

Journal: Gan To Kagaku Ryoho. 1983 Mar;10(3):756-62.
Title: [A study on postoperative long-term continuous immuno-chemotherapy with PSK and 5-FUDS for advanced gastric and colo-rectal cancers].
Author: Saji, S|Kajima, T|Takao, H|Ban, K|Ohashi, H|Kunieda, T|Sakata, K
PMID: 6411000
Journal: Gan To Kagaku Ryoho. 1986 Feb;13(2):308-18.
Title: [Clinical results of a randomized controlled trial on the effect of adjuvant immunochemotherapy using Esquinon and Krestin in patients with curatively resected gastric cancer. Cooperative Study Group of Cancer Immunochemotherapy, Tokai Gastrointestinal On
Author: Nakazato, H|Ichihashi, H|Kondo, T
PMID: 3947108
Journal: Gan To Kagaku Ryoho. 1988 Aug;15(8):2229-36.
Title: [Clinical effect of postoperative adjuvant immunochemotherapy with the FT-207 suppository and PSK in colorectal cancer patients. Colorectal Cancer Chemotherapy Group in Hokuriku].
Author: Takashima, S|Kinami, Y|Miyazaki, I
PMID: 3136695
Journal: Gan To Kagaku Ryoho. 1989 Jun;16(6):2241-9.
Title: [Randomized controlled study on adjuvant immunochemotherapy with PSK in curatively resected colorectal cancer. The Cooperative Study Group of Surgical Adjuvant Immunochemotherapy for Cancer of Colon and Rectum].
Author: Mitomi, T|Tsuchiya, S|Iijima, N|Aso, K|Suzuki, K|Nishiyama, K|Amano, T|Takahashi, T|Murayama, N|Oka, H
PMID: 2500070
Journal: Cancer Immunol Immunother. 1990;31(5):261-8.
Title: Significant prolongation of disease-free period gained by oral polysaccharide K (PSK) administration after curative surgical operation of colorectal cancer.
Author: Torisu, M|Hayashi, Y|Ishimitsu, T|Fujimura, T|Iwasaki, K|Katano, M|Yamamoto, H|Kimura, Y|Takesue, M|Kondo, M
PMID: 2198088
Journal: Nihon Geka Gakkai Zasshi. 1992 Jul;93(7):770.
Title: [Immunological competence and effect of PSK in patients with gastric cancer and colon cancer: preliminary report].
Author: Hayashibe, A|Kito, H|Taruya, E|Sakamoto, K|Asada, K|Tokura, K|Takebayashi, J
PMID: 1508143
Journal: Jpn J Cancer Res. 1992 Jul;83(7):775-82.
Title: Antitumor effect of PSK at a distant site: tumor-specific immunity and combination with other chemotherapeutic agents.
Author: Ebina, T|Murata, K
PMID: 1517151
Journal: Biotherapy. 1992;4(2):117-28.
Title: Immunomodulation by orally administered protein-bound polysaccharide PSK in patients with gastrointestinal cancer.
Author: Nio, Y|Tsubono, M|Tseng, C C|Morimoto, H|Kawabata, K|Masai, Y|Shiraishi, T|Imai, S|Ohgaki, K|Tobe, T
PMID: 1622733
Journal: Dis Colon Rectum. 1992 Feb;35(2):123-30.
Title: Randomized, controlled study on adjuvant immunochemotherapy with PSK in curatively resected colorectal cancer. The Cooperative Study Group of Surgical Adjuvant Immunochemotherapy for Cancer of Colon and Rectum (Kanagawa).
Author: Mitomi, T|Tsuchiya, S|Iijima, N|Aso, K|Suzuki, K|Nishiyama, K|Amano, T|Takahashi, T|Murayama, N|Oka, H
PMID: 1735313
Journal: In Vivo. 1994 Mar-Apr;8(2):241-5.
Title: Enhancement of the antitumor effect by the concurrent use of a monoclonal antibody and the protein-bound polysaccharide PSK in mice bearing a human cancer cell line.
Author: Kanoh, T|Saito, K|Matsunaga, K|Oguchi, Y|Taniguchi, N|Endoh, H|Yoshimura, M|Fujii, T|Yoshikumi, C
PMID: 7919129
Journal: Gan To Kagaku Ryoho. 1995 Sep;22(11):1626-8.
Title: [Antitumor effect of intratumoral administration of BRM: inhibition of tumor cell invasion in vitro].
Author: Ebina, T|Murata, K
PMID: 7574777
Journal: Cancer Epidemiol Biomarkers Prev. 1995 Apr-May;4(3):275-81.
Title: Antimetastatic effects of PSK (Krestin), a protein-bound polysaccharide obtained from basidiomycetes: an overview.
Author: Kobayashi, H|Matsunaga, K|Oguchi, Y
PMID: 7606203
Journal: Anticancer Res. 1995 Mar-Apr;15(2):255-8.
Title: Polysaccharide preparation PSK augments the proliferation and cytotoxicity of tumor-infiltrating lymphocytes in vitro.
Author: Noguchi, K|Tanimura, H|Yamaue, H|Tsunoda, T|Iwahashi, M|Tani, M|Mizobata, S|Hotta, T|Arii, K|Tamai, M
PMID: 7762991
Journal: Anticancer Res. 1995 Sep-Oct;15(5B):2175-9.
Title: In vitro reactivity to a protein-bound polysaccharide PSK of peripheral blood lymphocytes from patients with gastrointestinal cancer.
Author: Sugimachi, K|Maehara, Y|Kusumoto, T|Okamura, T|Korenaga, D|Kohnoe, S|Baba, H|Anai, H
PMID: 8572620
Journal: Gan To Kagaku Ryoho. 1996 Sep;23(11):1549-52.
Title: [Regional adoptive immunotherapy using activated lymphocytes].
Author: Ebina, T|Isono, N|Murata, K|Yokoyama, J|Mikuni, J|Ohuchi, K
PMID: 8854802
Journal: Oncol Rep. 1996 Jan;3(1):151-3.
Title: Antitumor effect of the angiogenesis inhibitor TNP-470 and its combination effect with 5-FU and PSK in colon 26 tumors.
Author: Kitamura, M|Arai, K|Iwasaki, Y|Toi, M
PMID: 21594334
Journal: Int J Cancer. 1997 Jan 27;70(3):362-72.
Title: Oral administration of PSK can improve the impaired anti-tumor CD4+ T-cell response in gut-associated lymphoid tissue (GALT) of specific-pathogen-free mice.
Author: Harada, M|Matsunaga, K|Oguchi, Y|Iijima, H|Tamada, K|Abe, K|Takenoyama, M|Ito, O|Kimura, G|Nomoto, K
PMID: 9033641
Journal: Cancer Biother Radiopharm. 1997 Oct;12(5):341-4.
Title: Direct tumor growth suppressive effect of melanoidin extracted from immunomodulator-PSK.
Author: Kamei, H|Hashimoto, Y|Koide, T|Kojima, T|Hasegawa, M|Umeda, T
PMID: 10851484
Journal: Gan To Kagaku Ryoho. 1998 Jan;25(2):208-15.
Title: [Surgery and multidisciplinary treatment for colorectal cancer].
Author: Sakamoto, J|Kato, J|Yasue, M
PMID: 9474930
Journal: Immunopharmacology. 1998 Nov;40(3):219-30.
Title: Direct action of a protein-bound polysaccharide, PSK, on transforming growth factor-beta.
Author: Matsunaga, K|Hosokawa, A|Oohara, M|Sugita, N|Harada, M|Nomoto, K
PMID: 9858065
Journal: Oncol Rep. 2000 Nov-Dec;7(6):1343-7.
Title: Long-term survival after immunochemotherapy for juvenile colon cancer with peritoneal dissemination: a case report.
Author: Mukai, M|Tokunaga, N|Yasuda, S|Mukohyama, S|Kameya, T|Ishikawa, K|Iwase, H|Suzuki, T|Ishida, H|Sadahiro, S|Makuuchi, H
PMID: 11032941
Journal: Cancer Invest. 2002;20(2):166-73.
Title: Immunomodulatory effects of low dose cis-Diaminedichloroplatinum (cisplatin) combined with UFT and PSK in patients with advanced colorectal cancer.
Author: Shibata, Masahiko|Nezu, Takeshi|Kanou, Hisao|Nagata, Yasuhiko|Kimura, Tomo|Takekawa, Motoo|Ando, Katsuyuki|Fukuzawa, Masahiro
PMID: 11901535
Journal: Oncol Rep. 2002 May-Jun;9(3):635-8.
Title: Effectiveness of immunochemotherapy with PSK, a protein-bound polysaccharide, in colorectal cancer and changes of tumor marker.
Author: Kudo, Shinei|Tanaka, Jun-Ichi|Kashida, Hiroshi|Tamegai, Yoshiro|Endo, Shungo|Yamano, Hiro-O
PMID: 11956642
Journal: Int J Oncol. 2003 Jul;23(1):165-72.
Title: A randomized controlled trial of postoperative adjuvant immunochemotherapy for colorectal cancer with oral medicines.
Author: Koda, Keiji|Miyazaki, Masaru|Sarashina, Hiromi|Suwa, Toshikazu|Saito, Norio|Suzuki, Masaru|Ogawa, Kiyoshi|Watanabe, Satoshi|Kodaira, Susumu|Nakazato, Hiroaki
PMID: 12792790
Journal: Oncol Rep. 2004 Dec;12(6):1287-93.
Title: Gene expression in response to anti-tumour intervention by polysaccharide-K (PSK) in colorectal carcinoma cells.
Author: Yoshikawa, Reigetsu|Yanagi, Hidenori|Hashimoto-Tamaoki, Tomoko|Morinaga, Tomonori|Nakano, Yoshiro|Noda, Masafumi|Fujiwara, Yoshinori|Okamura, Haruki|Yamamura, Takehira
PMID: 15547752
Journal: Br J Cancer. 2004 Sep 13;91(6):1220-1; author reply 1221-3.
Title: Adjuvant immunochemotherapy with oral Tegafur/Uracil plus PSK in patients with stage II or III colorectal cancer.
Author: Alliot, C
PMID: 15305190
Journal: Oncol Rep. 2004 Mar;11(3):623-35.
Title: Significance of postoperative adjuvant immunochemotherapy after curative resection of colorectal cancers: identification of responders incorporating the age factor.
Author: Munemoto, Yoshinori|Iida, Yoshiro|Ohata, Kou|Saito, Hideo|Fujisawa, Katsunori|Kasahara, Yoshiro|Mitsui, Tsuyoshi|Asada, Yasuyuki|Miura, Shoji
PMID: 14767513
Journal: Int J Colorectal Dis. 2004 Mar;19(2):157-64.
Title: Long-term effect of 5-fluorouracil enhanced by intermittent administration of polysaccharide K after curative resection of colon cancer. A randomized controlled trial for 7-year follow-up.
Author: Ito, Katsuki|Nakazato, Hiroaki|Koike, Akihiko|Takagi, Hiroshi|Saji, Shigetoyo|Baba, Shozo|Mai, Masayoshi|Sakamoto, Jun-ichi|Ohashi, Yasuo
PMID: 13680286
Journal: Br J Cancer. 2004 Mar 8;90(5):1003-10.
Title: Adjuvant immunochemotherapy with oral Tegafur/Uracil plus PSK in patients with stage II or III colorectal cancer: a randomised controlled study.
Author: Ohwada, S|Ikeya, T|Yokomori, T|Kusaba, T|Roppongi, T|Takahashi, T|Nakamura, S|Kakinuma, S|Iwazaki, S|Ishikawa, H|Kawate, S|Nakajima, T|Morishita, Y
PMID: 14997197
Journal: Anticancer Res. 2005 Jan-Feb;25(1B):443-9.
Title: Effects of PSK on T and dendritic cells differentiation in gastric or colorectal cancer patients.
Author: Kanazawa, Masashi|Yoshihara, Kazue|Abe, Hiroyuki|Iwadate, Manabu|Watanabe, Kumiko|Suzuki, Satoshi|Endoh, Yoshiyuki|Takita, Ken-Ichi|Sekikawa, Kouji|Takenoshita, Seiichi|Ogata, Takashi|Ohto, Hitoshi
PMID: 15816609
Journal: Anticancer Res. 2005 Mar-Apr;25(2B):1377-84.
Title: Preoperative CEA and PPD values as prognostic factors for immunochemotherapy using PSK and 5-FU.
Author: Takahashi, Yutaka|Mai, Masayoshi|Nakazato, Hiroaki
PMID: 15865094
Journal: Gan To Kagaku Ryoho. 2005 Jun;32(6):863-5.
Title: [A case of metastatic submandibular lymphnode treated successfully with palliative oral (5-FU + PSK) chemotherapy in the elderly].
Author: Suzuki, Hirofumi|Yamamoto, Kazuo|Hayashi, Shinichi|Shindo, Hiroshi|Tonouchi, Akihiko|Yamamori, Hideo
PMID: 15984533
Journal: Gan To Kagaku Ryoho. 2005 Oct;32(11):1568-70.
Title: [Usefulness in predicting parameters for the selection of responders who received immunochemotherapy with PSK in patients with colorectal cancer].
Author: Yoshino, Shigefumi|Hazama, Shoichi|Shimizu, Ryouichi|Fukuda, Shintaroh|Kudoh, Akitoshi|Mizuta, Eishi|Ogura, Yutaka|Sano, Akiko|Oka, Masaaki
PMID: 16315871
Journal: Cancer Immunol Immunother. 2006 Apr;55(4):404-11.
Title: Efficacy of adjuvant immunochemotherapy with polysaccharide K for patients with curatively resected colorectal cancer: a meta-analysis of centrally randomized controlled clinical trials.
Author: Sakamoto, Junichi|Morita, Satoshi|Oba, Koji|Matsui, Takanori|Kobayashi, Michiya|Nakazato, Hiroaki|Ohashi, Yasuo
PMID: 16133112
Journal: Shock. 2006 Jan;25(1):36-42.
Title: Protective effect of a protein-bound polysaccharide, PSK, on CLP-induced sepsis in mice transplanted orthotopically with colon tumor.
Author: Ohmura, Yoshio|Matsunaga, Kenichi|Suzuki, Tatsuo
PMID: 16369184
Journal: Oncol Rep. 2006 Apr;15(4):861-8.
Title: Beneficial effects of protein-bound polysaccharide K plus tegafur/uracil in patients with stage II or III colorectal cancer: analysis of immunological parameters.
Author: Ohwada, Susumu|Ogawa, Tetsushi|Makita, Fujio|Tanahashi, Yoshifumi|Ohya, Toshihiro|Tomizawa, Naoki|Satoh, Yoshihiro|Kobayashi, Isao|Izumi, Masaru|Takeyoshi, Izumi|Hamada, Kunihiro|Minaguchi, Shigeyuki|Togo, Yasushi|Toshihiko, Tago|Koyama, Toru|Kamio, Masas
PMID: 16525672
Journal: Gan To Kagaku Ryoho. 2006 Jun;33(6):821-4.
Title: [A patient with hepatic, pulmonary, and nodal metastases of colon cancer responding to CPT-11/TS-1 therapy].
Author: Ishizuka, Tomoki|Yoshiyasu, Masayuki|Yanagi, Ken|Bando, Koichi|Yoshimura, Kazuyasu|Tajiri, Takashi
PMID: 16770105
Journal: Cell Mol Immunol. 2007 Aug;4(4):295-9.
Title: Enhancement of antitumor effect of tegafur/uracil (UFT) plus leucovorin by combined treatment with protein-bound polysaccharide, PSK, in mouse models.
Author: Katoh, Ryoji|Ooshiro, Mitsuru
PMID: 17764620
Journal: Gan To Kagaku Ryoho. 2009 Nov;36(12):1967-8.
Title: [Ten cases of advanced gastro-intestinal cancer that required preoperative dosage of PSK].
Author: Ooshiro, Mitsuru|Kitahara, Tomoaki|Takagi, Ryuichi|Moriyama, Ayako|Urita, Tasuku|Yoshida, Yutaka|Tanaka, Hiroshi|Nihonyanagi, Yasuhiro|Sugishita, Yuui|Oshiro, Takashi|Kinoshita, Takahiro|Nagashima, Makoto|Park, Youngjin|Okazumi, Shinichi|Katoh, Ryoji
PMID: 20037293
Journal: Gan To Kagaku Ryoho. 2009 Nov;36(12):2184-6.
Title: [A case of ascending colon cancer successfully treated for synchronous liver metastases with mFOLFOX6 after a resection of the primary tumor].
Author: Tomochika, Shinobu|Hazama, Shouichi|Nakatsu, Hiroki|Yoshida, Shin|Tokuhisa, Yoshihiro|Yoshino, Shigefumi|Oka, Masaaki
PMID: 20037364
Journal: Int J Clin Oncol. 2010 Apr;15(2):145-52.
Title: PSK may suppress CD57(+) T cells to improve survival of advanced gastric cancer patients.
Author: Akagi, Junji|Baba, Hideo
PMID: 20229169
Journal: Gan To Kagaku Ryoho. 2010 Nov;37(12):2234-6.
Title: [Immunoregulatory effects of PSK on the Th1/Th2 balance and regulatory T-cells in patients with colorectal cancer].
Author: Yoshino, Shigefumi|Yoshimura, Kiyoshi|Suzuki, Nobuaki|Iida, Michihisa|Yoshida, Shin|Maeda, Yoshinari|Maeda, Kazunari|Hazama, Shoichi|Oka, Masaaki
PMID: 21224532
Journal: Gan To Kagaku Ryoho. 2011 May;38(5):797-801.
Title: [PSK decreased FOLFOX4-induced peripheral neuropathy and bone marrow suppression in patients with metastatic colorectal cancer].
Author: Shibata, Masahiko|Shimura, Tatsuo|Nishina, Yumiko|Gonda, Kenji|Matsuo, Sadanori|Abe, Hideo|Yajima, Yukihiro|Nakamura, Izumi|Ohki, Shinji|Takenoshita, Seiichi
PMID: 21566440
Journal: Oncol Lett. 2011 May;2(3):509-514.
Title: A review of the anti-tumor effect of the combined administration of a cyclooxygenase-2 selective inhibitor and a non-specific immunostimulant protein-bound polysaccharide on an advanced colon cancer model using colon cancer cell lines.
Author: Katsumata, Kenji|Musiake, Noriyuki|Shibuya, Kentaro|Nakajima, Takahiro|Watanabe, Masato|Sasaki, Motoyuki|Sugiyama, Yasuyuki
PMID: 22866112
Journal: Cancer Sci. 2012 Feb;103(2):317-24.
Title: Direct inhibition of the transforming growth factor-beta pathway by protein-bound polysaccharide through inactivation of Smad2 signaling.
Author: Ono, Yoshihiro|Hayashida, Tetsu|Konagai, Ayano|Okazaki, Hiroshi|Miyao, Kazuhiro|Kawachi, Shigeyuki|Tanabe, Minoru|Shinoda, Masahiro|Jinno, Hiromitsu|Hasegawa, Hirotoshi|Kitajima, Masaki|Kitagawa, Yuko
PMID: 22034928
Journal: Surg Today. 2012 Jan;42(1):8-28.
Title: Biological mechanism and clinical effect of protein-bound polysaccharide K (KRESTIN((R))): review of development and future perspectives.
Author: Maehara, Yoshihiko|Tsujitani, Shunichi|Saeki, Hiroshi|Oki, Eiji|Yoshinaga, Keiji|Emi, Yasunori|Morita, Masaru|Kohnoe, Shunji|Kakeji, Yoshihiro|Yano, Tokujiro|Baba, Hideo
PMID: 22139128
Journal: Gan To Kagaku Ryoho. 2012 Nov;39(12):1782-4.
Title: [Two cases of long-term survival of metastatic colorectal cancer following treatment with polysaccharide K and mFOLFOX6 therapy].
Author: Ohta, Kyosuke|Matsui, Shoji|Sato, Yoshiharu|Murao, Shinichi
PMID: 23267885
Journal: Int J Oncol. 2013 Apr;42(4):1175-80.
Title: The expression of integrins is decreased in colon cancer cells treated with polysaccharide K.
Author: Aso, Keiko|Goi, Takanori|Nakazawa, Toshiyuki|Kimura, Youhei|Hirono, Yasuo|Katayama, Kanji|Yamaguchi, Akio
PMID: 23427003
Journal: Oncol Rep. 2013 Dec;30(6):2845-51.
Title: Protein-bound polysaccharide-K augments the anticancer effect of fluoropyrimidine derivatives possibly by lowering dihydropyrimidine dehydrogenase expression in gastrointestinal cancers.
Author: Mekata, Eiji|Murata, Satoshi|Sonoda, Hiromichi|Shimizu, Tomoharu|Umeda, Tomoko|Shiomi, Hisanori|Naka, Shigeyuki|Yamamoto, Hiroshi|Abe, Hajime|Edamatsu, Takeo|Fujieda, Ayako|Fujioka, Masaki|Wada, Tsutomu|Tani, Tohru
PMID: 24100378
Journal: Anticancer Res. 2013 Nov;33(11):4841-5.
Title: Protein-bound polysaccharide K reduced the invasive ability of colon cancer cell lines.
Author: Uwafuji, Seiko|Goi, Takanori|Naruse, Takayuki|Kurebayashi, Hidetaka|Nakazawa, Toshiyuki|Hirono, Yasuo|Yamaguchi, Akio
PMID: 24222121
Journal: Gan To Kagaku Ryoho. 2013 Dec;40(13):2525-8.
Title: [Subset analysis of preoperative lymphocyte ratio in stage II or III colorectal cancer patients treated with oral tegafur-uracil and protein-bound polysaccharide K].
Author: Totsuka, Osamu|Kawate, Susumu|Hirai, Keitaro|Ogawa, Hiroomi|Toya, Hiroyuki|Yoshinari, Daisuke|Sunose, Yutaka|Takeyoshi, Izumi
PMID: 24335363
Journal: Gan To Kagaku Ryoho. 2013 Nov;40(12):1593-5.
Title: [Analysis of the eligibility of elderly colorectal cancer patients for adjuvant chemotherapy combined with polysaccharide K].
Author: Munemoto, Yoshinori|Takashima, Yoshihiro|Saito, Kenichiro|Kato, Shigeru|Kadoya, Shinichi|Terada, Takuro|Amaya, Susumu|Ishida, Makoto|Iida, Yoshiro|Mitsui, Takeshi
PMID: 24393859
Journal: Gan To Kagaku Ryoho. 2013 Nov;40(12):2086-8.
Title: [Clinical significance of neutrophil to lymphocyte ratio in colorectal cancer patients receiving adjuvant chemotherapy combined with polysaccharide-K].
Author: Yoshioka, Shinichi|Kubo, Masahiko|Yanagisawa, Kiminori|Hata, Tsuyoshi|Takiuchi, Daisuke|Hamano, Rie|Minohata, Junya|Kashiwazaki, Masaki|Miki, Hirofumi|Tsujie, Masaki|Konishi, Muneharu|Yano, Hiroshi
PMID: 24394021
Journal: Fukuoka Igaku Zasshi. 2013 Dec;104(12):549-58.
Title: Prognostic markers for immunochemotherapy using tegafur -uracil (UFT) and protein-bound polysaccharide K (PSK).
Author: Yoshinaga, Keiji|Saeki, Hiroshi|Oki, Eiji|Morita, Masaru|Ikeda, Tetsuo|Sugimachi, Keishi|Yamashita, Yo-Ichi|Ikegami, Toru|Uchiyama, Hideaki|Yoshizumi, Tomoharu|Soejima, Yuji|Kawanaka, Hirofumi|Mimori, Koshi|Watanabe, Masayuki|Maehara, Yoshihiko
PMID: 24693683