Literatures

Primary Site >> Pancreatic Cancer

Gene >> STK11

1.
Journal:	Am J Pathol. 1999 Jun;154(6):1835-40.
Title:	Germline and somatic mutations of the STK11/LKB1 Peutz-Jeghers gene in pancreatic and biliary cancers.
Author:	Su, G H\|Hruban, R H\|Bansal, R K\|Bova, G S\|Tang, D J\|Shekher, M C\|Westerman, A M\|Entius, M M\|Goggins, M\|Yeo, C J\|Kern, S E
PMID:	10362809

2.
Journal:	Ann Oncol. 1999;10 Suppl 4:4-8.
Title:	Progress in cancer genetics: lessons from pancreatic cancer.
Author:	Goggins, M\|Kern, S E\|Offerhaus, J A\|Hruban, R H
PMID:	10436774

3.
Journal:	Ann Oncol. 1999;10 Suppl 4:69-73.
Title:	Familial pancreatic cancer.
Author:	Hruban, R H\|Petersen, G M\|Goggins, M\|Tersmette, A C\|Offerhaus, G J\|Falatko, F\|Yeo, C J\|Kern, S E
PMID:	10436789

4.
Journal:	Am J Pathol. 1999 Mar;154(3):677-81.
Title:	LKB1 somatic mutations in sporadic tumors.
Author:	Avizienyte, E\|Loukola, A\|Roth, S\|Hemminki, A\|Tarkkanen, M\|Salovaara, R\|Arola, J\|Butzow, R\|Husgafvel-Pursiainen, K\|Kokkola, A\|Jarvinen, H\|Aaltonen, L A
PMID:	10079245

5.
Journal:	Curr Opin Gastroenterol. 2000 Sep;16(5):419-25.
Title:	Molecular genetics of ductal pancreatic neoplasia.
Author:	Su, G H\|Kern, S E
PMID:	17031113

6.
Journal:	Dig Dis. 2001;19(1):76-84.
Title:	Prevention of pancreatic cancer and strategies for management of familial pancreatic cancer.
Author:	Hruban, R H\|Canto, M I\|Yeo, C J
PMID:	11385254

7.
Journal:	Cancer J. 2001 Jul-Aug;7(4):266-73.
Title:	Familial pancreatic cancer.
Author:	Klein, A P\|Hruban, R H\|Brune, K A\|Petersen, G M\|Goggins, M
PMID:	11561603

8.
Journal:	Am J Pathol. 2001 Dec;159(6):2017-22.
Title:	STK11/LKB1 Peutz-Jeghers gene inactivation in intraductal papillary-mucinous neoplasms of the pancreas.
Author:	Sato, N\|Rosty, C\|Jansen, M\|Fukushima, N\|Ueki, T\|Yeo, C J\|Cameron, J L\|Iacobuzio-Donahue, C A\|Hruban, R H\|Goggins, M
PMID:	11733352

9.
Journal:	Pancreatology. 2001;1(6):571-5.
Title:	Pancreatic cancer genetics.
Author:	Efthimiou, E\|Crnogorac-Jurcevic, T\|Lemoine, N R
PMID:	12120238

10.
Journal:	Cancer Biol Ther. 2003 Jan-Feb;2(1):38-47.
Title:	Clinicopathologic and molecular features of pancreatic adenocarcinoma associated with Peutz-Jeghers syndrome.
Author:	Yee, Nelson S\|Furth, Emma E\|Pack, Michael
PMID:	12673116

11.
Journal:	Neoplasia. 2003 Jul-Aug;5(4):367-74.
Title:	Restoration of silenced Peutz-Jeghers syndrome gene, LKB1, induces apoptosis in pancreatic carcinoma cells.
Author:	Qanungo, Suparna\|Haldar, Subrata\|Basu, Aruna
PMID:	14511408

12.
Journal:	Biochem Biophys Res Commun. 2004 Nov 19;324(3):986-92.
Title:	IGF-1 phosphorylates AMPK-alpha subunit in ATM-dependent and LKB1-independent manner.
Author:	Suzuki, Atsushi\|Kusakai, Gen-ichi\|Kishimoto, Atsuhiro\|Shimojo, Yosuke\|Ogura, Tsutomu\|Lavin, Martin F\|Esumi, Hiroyasu
PMID:	15485651

13.
Journal:	Fam Cancer. 2004;3(3-4):233-40.
Title:	Familial pancreatic carcinoma in Jews.
Author:	Lynch, Henry T\|Deters, Carolyn A\|Lynch, Jane F\|Brand, Randall E
PMID:	15516847

14.
Journal:	Cancer Lett. 2004 Oct 8;214(1):63-8.
Title:	No evidence for germline mutations of the LKB1/STK11 gene in familial pancreatic carcinoma.
Author:	Grutzmann, Robert\|McFaul, Christopher\|Bartsch, Detlef K\|Sina-Frey, Mercedes\|Rieder, Harald\|Koch, Rainer\|McCarthy, Emma\|Greenhalf, William\|Neoptolemos, John P\|Saeger, Hans Detlev\|Pilarsky, Christian
PMID:	15331174

15.
Journal:	Methods Mol Med. 2005;103:329-41.
Title:	Overview of linkage analysis: application to pancreatic cancer.
Author:	Klein, Alison P
PMID:	15542915

16.
Journal:	Curr Treat Options Gastroenterol. 2005 Oct;8(5):365-75.
Title:	Treatment of familial pancreatic cancer and its precursors.
Author:	Hruban, Ralph H\|Canto, Marcia I\|Griffin, Constance\|Kern, Scott E\|Klein, Alison P\|Laheru, Dan\|Yeo, Charles J
PMID:	16162302

17.
Journal:	Magy Onkol. 2006;50(2):163-8.
Title:	[Familial pancreatic cancer].
Author:	Zalatnai, Attila
PMID:	16888680

18.
Journal:	Cancer Biol Ther. 2007 Mar;6(3):320-3. Epub 2007 Mar 15.
Title:	Linkage analysis of chromosome 4 in families with familial pancreatic cancer.
Author:	Klein, Alison P\|de Andrade, Mariza\|Hruban, Ralph H\|Bondy, Melissa\|Schwartz, Ann G\|Gallinger, Steven\|Lynch, Henry T\|Syngal, Sapna\|Rabe, Kari G\|Goggins, Michael G\|Petersen, Gloria M
PMID:	17312386

19.
Journal:	Expert Rev Gastroenterol Hepatol. 2007 Oct;1(1):81-8.
Title:	Familial pancreatic cancer: from genes to improved patient care.
Author:	Hruban, Ralph H\|Klein, Alison P\|Eshleman, James R\|Axilbund, Jennifer E\|Goggins, Michael
PMID:	19072437

20.
Journal:	Mol Cell Biol. 2008 Apr;28(7):2414-25.
Title:	Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms.
Author:	Hezel, Aram F\|Gurumurthy, Sushma\|Granot, Zvi\|Swisa, Avital\|Chu, Gerry C\|Bailey, Gerald\|Dor, Yuval\|Bardeesy, Nabeel\|Depinho, Ronald A
PMID:	18227155

21.
Journal:	Cancer Genet Cytogenet. 2010 Mar;197(2):130-41.
Title:	Homozygous deletion of the STK11/LKB1 locus and the generation of novel fusion transcripts in cervical cancer cells.
Author:	McCabe, Michael T\|Powell, Doris R\|Zhou, Wei\|Vertino, Paula M
PMID:	20193846

22.
Journal:	Gastroenterology. 2010 Aug;139(2):586-97, 597.e1-6.
Title:	LKB1 haploinsufficiency cooperates with Kras to promote pancreatic cancer through suppression of p21-dependent growth arrest.
Author:	Morton, Jennifer P\|Jamieson, Nigel B\|Karim, Saadia A\|Athineos, Dimitris\|Ridgway, Rachel A\|Nixon, Colin\|McKay, Colin J\|Carter, Ross\|Brunton, Valerie G\|Frame, Margaret C\|Ashworth, Alan\|Oien, Karin A\|Evans, T R Jeffry\|Sansom, Owen J
PMID:	20452353

23.
Journal:	Mol Cancer Ther. 2011 Dec;10(12):2426-36.
Title:	GDC-0980 is a novel class I PI3K/mTOR kinase inhibitor with robust activity in cancer models driven by the PI3K pathway.
Author:	Wallin, Jeffrey J\|Edgar, Kyle A\|Guan, Jane\|Berry, Megan\|Prior, Wei Wei\|Lee, Leslie\|Lesnick, John D\|Lewis, Cristina\|Nonomiya, Jim\|Pang, Jodie\|Salphati, Laurent\|Olivero, Alan G\|Sutherlin, Daniel P\|O'Brien, Carol\|Spoerke, Jill M\|Patel, Sonal\|Lensun, Letitia\|
PMID:	21998291

24.
Journal:	Surgery. 2011 Aug;150(2):284-98.
Title:	Angiotensin II type 2 receptor blockade inhibits fatty acid synthase production through activation of AMP-activated protein kinase in pancreatic cancer cells.
Author:	McGhee, Amy\|Sivarajah, Maheshwaran\|Gong, Qiaoke\|Lim, SuhYueh\|Chipitsyna, Galina\|Yeo, Charles J\|Arafat, Hwyda A
PMID:	21801966

25.
Journal:	Fam Cancer. 2011 Sep;10(3):463-8.
Title:	Case studies in the diagnosis and management of Peutz-Jeghers syndrome.
Author:	Riegert-Johnson, Douglas\|Roberts, Maegan\|Gleeson, Ferga C\|Krishna, Murli\|Boardman, Lisa
PMID:	21503748

26.
Journal:	Fam Cancer. 2011 Jun;10(2):323-30.
Title:	German national case collection for familial pancreatic cancer (FaPaCa): ten years experience.
Author:	Schneider, Ralph\|Slater, Emily P\|Sina, Mercede\|Habbe, Nils\|Fendrich, Volker\|Matthai, Elvira\|Langer, Peter\|Bartsch, Detlef K
PMID:	21207249

27.
Journal:	Mod Pathol. 2011 Sep;24(9):1229-36.
Title:	Analysis of LKB1 mutations and other molecular alterations in pancreatic acinar cell carcinoma.
Author:	de Wilde, Roeland F\|Ottenhof, Niki A\|Jansen, Marnix\|Morsink, Folkert H M\|de Leng, Wendy W J\|Offerhaus, G Johan A\|Brosens, Lodewijk A A
PMID:	21572398

28.
Journal:	Cancer J. 2012 Nov-Dec;18(6):485-91.
Title:	Inherited pancreatic cancer syndromes.
Author:	Solomon, Sheila\|Das, Siddhartha\|Brand, Randall\|Whitcomb, David C
PMID:	23187834

29.
Journal:	J Med Genet. 2013 Jan;50(1):59-64.
Title:	Pancreatic cancer risk in Peutz-Jeghers syndrome patients: a large cohort study and implications for surveillance.
Author:	Korsse, Susanne E\|Harinck, Femme\|van Lier, Margot G F\|Biermann, Katharina\|Offerhaus, G Johan A\|Krak, Nanda\|Looman, Caspar W N\|van Veelen, Wendy\|Kuipers, Ernst J\|Wagner, Anja\|Dekker, Evelien\|Mathus-Vliegen, Elisabeth M H\|Fockens, Paul\|van Leerdam, Monique
PMID:	23240097

30.
Journal:	Tumour Biol. 2014 Feb;35(2):995-1002.
Title:	The tumor suppressor LKB1 antagonizes WNT signaling pathway through modulating GSK3beta activity in cell growth of esophageal carcinoma.
Author:	Liu, Kai\|Luo, Yue\|Tian, Hui\|Yu, Kai-Zhong\|He, Jin-Xian\|Shen, Wei-Yu
PMID:	24022664

31.
Journal:	Mol Med Rep. 2014 Jun;9(6):2400-4.
Title:	Downregulation of LKB1 suppresses Stat3 activity to promote the proliferation of esophageal carcinoma cells.
Author:	Wang, Yu-Qi\|Dai, Wei-Min\|Chu, Xiang-Yang\|Yang, Bo\|Zhao, Ming\|Sun, Yu'e
PMID:	24676538

32.
Journal:	Bull Cancer. 2014 Sep;101(9):813-22.
Title:	[Hereditary predisposition to cancers of the digestive tract, breast, gynecological and gonadal: focus on the Peutz-Jeghers].
Author:	Turpin, Anthony\|Cattan, Stephane\|Leclerc, Julie\|Wacrenier, Agnes\|Manouvrier-Hanu, Sylvie\|Buisine, Marie-Pierre\|Lejeune-Dumoulin, Sophie
PMID:	25036236

33.
Journal:	World J Gastroenterol. 2014 Aug 21;20(31):10864-75.
Title:	Update on imaging of Peutz-Jeghers syndrome.
Author:	Tomas, Catherine\|Soyer, Philippe\|Dohan, Anthony\|Dray, Xavier\|Boudiaf, Mourad\|Hoeffel, Christine
PMID:	25152588

34.
Journal:	Nat Genet. 2015 Aug;47(8):911-6.
Title:	Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer.
Author:	Childs, Erica J\|Mocci, Evelina\|Campa, Daniele\|Bracci, Paige M\|Gallinger, Steven\|Goggins, Michael\|Li, Donghui\|Neale, Rachel E\|Olson, Sara H\|Scelo, Ghislaine\|Amundadottir, Laufey T\|Bamlet, William R\|Bijlsma, Maarten F\|Blackford, Amanda\|Borges, Michael\|Brenn
PMID:	26098869

35.
Journal:	Genes Dev. 2015 Jul 15;29(14):1576-85.
Title:	Pancreatic cancer modeling using retrograde viral vector delivery and in vivo CRISPR/Cas9-mediated somatic genome editing.
Author:	Chiou, Shin-Heng\|Winters, Ian P\|Wang, Jing\|Naranjo, Santiago\|Dudgeon, Crissy\|Tamburini, Fiona B\|Brady, Jennifer J\|Yang, Dian\|Gruner, Barbara M\|Chuang, Chen-Hua\|Caswell, Deborah R\|Zeng, Hong\|Chu, Pauline\|Kim, Grace E\|Carpizo, Darren R\|Kim, Seung K\|Winslow,
PMID:	26178787

36.
Journal:	Cancer Genet. 2015 Jul-Aug;208(7-8):374-81.
Title:	Exome-level comparison of primary well-differentiated neuroendocrine tumors and their cell lines.
Author:	Boora, Ganesh K\|Kanwar, Rahul\|Kulkarni, Amit A\|Pleticha, Josef\|Ames, Matthew\|Schroth, Gary\|Beutler, Andreas S\|Banck, Michaela S
PMID:	26087898

37.
Journal:	Oncotarget. 2015 Mar 10;6(7):4553-61.
Title:	Molecular landscape of pancreatic cancer: implications for current clinical trials.
Author:	Heestand, Gregory M\|Kurzrock, Razelle
PMID:	25714017

38.
Journal:	Gastroenterology. 2015 Mar;148(3):556-64.
Title:	Prevalence of germline mutations in cancer predisposition genes in patients with pancreatic cancer.
Author:	Grant, Robert C\|Selander, Iris\|Connor, Ashton A\|Selvarajah, Shamini\|Borgida, Ayelet\|Briollais, Laurent\|Petersen, Gloria M\|Lerner-Ellis, Jordan\|Holter, Spring\|Gallinger, Steven
PMID:	25479140

39.
Journal:	Pigment Cell Melanoma Res. 2015 Jan;28(1):8-20.
Title:	Is it time to test biguanide metformin in the treatment of melanoma?
Author:	Cerezo, Michael\|Tomic, Tijana\|Ballotti, Robert\|Rocchi, Stephane
PMID:	24862830

40.
Journal:	Oncotarget. 2015 Mar 10;6(7):4553-61.
Title:	Molecular landscape of pancreatic cancer: implications for current clinical trials.
Author:	Heestand, Gregory M\|Kurzrock, Razelle
PMID:	11051691

41.
Journal:	Acta Biochim Biophys Sin (Shanghai). 2016 Jan;48(1):27-38.
Title:	RAS signaling and anti-RAS therapy: lessons learned from genetically engineered mouse models, human cancer cells, and patient-related studies.
Author:	Fang, Bingliang
PMID:	26350096

42.
Journal:	Cancer Chemother Pharmacol. 2016 Feb;77(2):235-42.
Title:	Metformin and pancreatic cancer: Is there a role?
Author:	De Souza, Andre\|Khawaja, Khadija Irfan\|Masud, Faisal\|Saif, Muhammad Wasif
PMID:	26740120

43.
Journal:	CNS Oncol. 2016 Oct;5(4):203-9.
Title:	Widely metastatic atypical pituitary adenoma with mTOR pathway STK11(F298L) mutation treated with everolimus therapy.
Author:	Donovan, Laura E\|Arnal, Ashley V\|Wang, Shih-Hsiu\|Odia, Yazmin
PMID:	27615706

44.
Journal:	Hum Mol Genet. 2016 Nov 15;25(22):5017-5026.
Title:	Chronic pancreatitis and lipomatosis are associated with defective function of ciliary genes in pancreatic ductal cells.
Author:	Augereau, Cecile\|Collet, Louis\|Vargiu, Pierfrancesco\|Guerra, Carmen\|Ortega, Sagrario\|Lemaigre, Frederic P\|Jacquemin, Patrick
PMID:	28159992

45.
Journal:	Cancer Lett. 2017 Aug 1;400:69-78.
Title:	microRNA-7 impairs autophagy-derived pools of glucose to suppress pancreatic cancer progression.
Author:	Gu, Dian-Na\|Jiang, Ming-Jie\|Mei, Zhu\|Dai, Juan-Juan\|Dai, Chen-Yun\|Fang, Chi\|Huang, Qian\|Tian, Ling
PMID:	28450156

46.
Journal:	J Biol Chem. 2017 Jun 30;292(26):10813-10823.
Title:	The FOXO3/PGC-1beta signaling axis is essential for cancer stem cell properties of pancreatic ductal adenocarcinoma.
Author:	Kumazoe, Motofumi\|Takai, Mika\|Hiroi, Shun\|Takeuchi, Chieri\|Kadomatsu, Mai\|Nojiri, Takashi\|Onda, Hiroaki\|Bae, Jaehoon\|Huang, Yuhui\|Takamatsu, Kanako\|Yamashita, Shuya\|Kangawa, Kenji\|Tachibana, Hirofumi
PMID:	28507102

47.
Journal:	Oncotarget. 2017 Sep 16;8(58):98068-98083.
Title:	The regulatory role of aberrant Phosphatase and Tensin Homologue and Liver Kinase B1 on AKT/mTOR/c-Myc axis in pancreatic neuroendocrine tumors.
Author:	Chang, Tsung-Ming\|Shan, Yan-Shen\|Chu, Pei-Yi\|Jiang, Shih Sheng\|Hung, Wen-Chun\|Chen, Yu-Lin\|Tu, Hsiu-Chi\|Lin, Hui-You\|Tsai, Hui-Jen\|Chen, Li-Tzong
PMID:	29228674

48.
Journal:	Mol Med Rep. 2018 Jan;17(1):216-224.
Title:	Construction of a prognostic prediction system for pancreatic ductal adenocarcinoma to investigate the key prognostic genes.
Author:	Zheng, Bingli\|Peng, Jie\|Mollayup, Ablikim\|Bakri, Ahmat\|Guo, Lei\|Zheng, Jianjiang\|Xu, Hui
PMID:	29115420

49.
Journal:	Gastrointest Endosc. 2018 Jun;87(6):1443-1450.
Title:	Pancreatic cancer screening in high-risk individuals with germline genetic mutations.
Author:	DaVee, Tomas\|Coronel, Emmanuel\|Papafragkakis, Charilaos\|Thaiudom, Sayam\|Lanke, Gandhi\|Chakinala, Raja C\|Nogueras Gonzalez, Graciela M\|Bhutani, Manoop S\|Ross, William A\|Weston, Brian R\|Lee, Jeffrey H
PMID:	29309780

50.
Journal:	Oncologist. 2018 Apr;23(4):399-e33.
Title:	Chemoprevention in Patients with Peutz-Jeghers Syndrome: Lessons Learned.
Author:	de Brabander, Justin\|Eskens, Ferry A L M\|Korsse, Susanne E\|Dekker, Evelien\|Dewint, Pieter\|van Leerdam, Monique E\|van Eeden, Susanne\|Klumpen, Heinz-Josef
PMID:	29371475

51.
Journal:	Cancer Sci. 2018 May;109(5):1382-1392.
Title:	LKB1 obliterates Snail stability and inhibits pancreatic cancer metastasis in response to metformin treatment.
Author:	Song, Lele\|Guo, Jingyu\|Chang, Renxu\|Peng, Xiaobo\|Li, Jie\|Xu, Xiaorong\|Zhan, Xianbao\|Zhan, Lixing
PMID:	29601127

52.
Journal:	Clin Cancer Res. 2018 Sep 15;24(18):4444-4454.
Title:	Integrated Genomic and Immunophenotypic Classification of Pancreatic Cancer Reveals Three Distinct Subtypes with Prognostic/Predictive Significance.
Author:	Wartenberg, Martin\|Cibin, Silvia\|Zlobec, Inti\|Vassella, Erik\|Eppenberger-Castori, Serenella\|Terracciano, Luigi\|Eichmann, Micha David\|Worni, Mathias\|Gloor, Beat\|Perren, Aurel\|Karamitopoulou, Eva
PMID:	29661773