Primary Site >> Pancreatic Cancer
Gene >> STK11
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Ref: LKB1 somatic mutations in sporadic tumors. PMID: 10079245 Ref: Germline and somatic mutations of the STK11/LKB1 Peutz-Jeghers gene in pancreatic and biliary cancers. PMID: 10362809 Ref: Progress in cancer genetics: lessons from pancreatic cancer. PMID: 10436774 Ref: Familial pancreatic cancer. PMID: 10436789 |
Ref: Molecular genetics of ductal pancreatic neoplasia. PMID: 17031113 |
Ref: Prevention of pancreatic cancer and strategies for management of familial pancreatic cancer. PMID: 11385254 Ref: Familial pancreatic cancer. PMID: 11561603 Ref: STK11/LKB1 Peutz-Jeghers gene inactivation in intraductal papillary-mucinous neoplasms of the pancreas. PMID: 11733352 Ref: Pancreatic cancer genetics. PMID: 12120238 |
Ref: Clinicopathologic and molecular features of pancreatic adenocarcinoma associated with Peutz-Jeghers syndrome. PMID: 12673116 Ref: Restoration of silenced Peutz-Jeghers syndrome gene, LKB1, induces apoptosis in pancreatic carcinoma cells. PMID: 14511408 |
Ref: No evidence for germline mutations of the LKB1/STK11 gene in familial pancreatic carcinoma. PMID: 15331174 Ref: IGF-1 phosphorylates AMPK-alpha subunit in ATM-dependent and LKB1-independent manner. PMID: 15485651 Ref: Familial pancreatic carcinoma in Jews. PMID: 15516847 |
Ref: Overview of linkage analysis: application to pancreatic cancer. PMID: 15542915 Ref: Treatment of familial pancreatic cancer and its precursors. PMID: 16162302 |
Ref: [Familial pancreatic cancer]. PMID: 16888680 |
Ref: Linkage analysis of chromosome 4 in families with familial pancreatic cancer. PMID: 17312386 Ref: Familial pancreatic cancer: from genes to improved patient care. PMID: 19072437 |
Ref: Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms. PMID: 18227155 |
Ref: Homozygous deletion of the STK11/LKB1 locus and the generation of novel fusion transcripts in cervical cancer cells. PMID: 20193846 Ref: LKB1 haploinsufficiency cooperates with Kras to promote pancreatic cancer through suppression of p21-dependent growth arrest. PMID: 20452353 |
Ref: German national case collection for familial pancreatic cancer (FaPaCa): ten years experience. PMID: 21207249 Ref: Case studies in the diagnosis and management of Peutz-Jeghers syndrome. PMID: 21503748 Ref: Analysis of LKB1 mutations and other molecular alterations in pancreatic acinar cell carcinoma. PMID: 21572398 Ref: Angiotensin II type 2 receptor blockade inhibits fatty acid synthase production through activation of AMP-activated protein kinase in pancreatic cancer cells. PMID: 21801966 Ref: GDC-0980 is a novel class I PI3K/mTOR kinase inhibitor with robust activity in cancer models driven by the PI3K pathway. PMID: 21998291 |
Ref: Inherited pancreatic cancer syndromes. PMID: 23187834 |
Ref: Pancreatic cancer risk in Peutz-Jeghers syndrome patients: a large cohort study and implications for surveillance. PMID: 23240097 |
Ref: The tumor suppressor LKB1 antagonizes WNT signaling pathway through modulating GSK3beta activity in cell growth of esophageal carcinoma. PMID: 24022664 Ref: Downregulation of LKB1 suppresses Stat3 activity to promote the proliferation of esophageal carcinoma cells. PMID: 24676538 Ref: [Hereditary predisposition to cancers of the digestive tract, breast, gynecological and gonadal: focus on the Peutz-Jeghers]. PMID: 25036236 Ref: Update on imaging of Peutz-Jeghers syndrome. PMID: 25152588 |
Ref: Molecular landscape of pancreatic cancer: implications for current clinical trials. PMID: 11051691 Ref: Is it time to test biguanide metformin in the treatment of melanoma? PMID: 24862830 Ref: Prevalence of germline mutations in cancer predisposition genes in patients with pancreatic cancer. PMID: 25479140 Ref: Molecular landscape of pancreatic cancer: implications for current clinical trials. PMID: 25714017 Ref: Exome-level comparison of primary well-differentiated neuroendocrine tumors and their cell lines. PMID: 26087898 Ref: Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer. PMID: 26098869 Ref: Pancreatic cancer modeling using retrograde viral vector delivery and in vivo CRISPR/Cas9-mediated somatic genome editing. PMID: 26178787 |
Ref: RAS signaling and anti-RAS therapy: lessons learned from genetically engineered mouse models, human cancer cells, and patient-related studies. PMID: 26350096 Ref: Metformin and pancreatic cancer: Is there a role? PMID: 26740120 Ref: Widely metastatic atypical pituitary adenoma with mTOR pathway STK11(F298L) mutation treated with everolimus therapy. PMID: 27615706 Ref: Chronic pancreatitis and lipomatosis are associated with defective function of ciliary genes in pancreatic ductal cells. PMID: 28159992 |
Ref: microRNA-7 impairs autophagy-derived pools of glucose to suppress pancreatic cancer progression. PMID: 28450156 Ref: The FOXO3/PGC-1beta signaling axis is essential for cancer stem cell properties of pancreatic ductal adenocarcinoma. PMID: 28507102 Ref: The regulatory role of aberrant Phosphatase and Tensin Homologue and Liver Kinase B1 on AKT/mTOR/c-Myc axis in pancreatic neuroendocrine tumors. PMID: 29228674 |
Ref: Construction of a prognostic prediction system for pancreatic ductal adenocarcinoma to investigate the key prognostic genes. PMID: 29115420 Ref: Pancreatic cancer screening in high-risk individuals with germline genetic mutations. PMID: 29309780 Ref: Chemoprevention in Patients with Peutz-Jeghers Syndrome: Lessons Learned. PMID: 29371475 Ref: LKB1 obliterates Snail stability and inhibits pancreatic cancer metastasis in response to metformin treatment. PMID: 29601127 Ref: Integrated Genomic and Immunophenotypic Classification of Pancreatic Cancer Reveals Three Distinct Subtypes with Prognostic/Predictive Significance. PMID: 29661773 |