Primary Site >> Liver Cancer

Gene >> STAT3

Journal: J Immunol. 1996 Jul 1;157(1):284-90.
Title: Complex of the soluble IL-11 receptor and IL-11 acts as IL-6-type cytokine in hepatic and nonhepatic cells.
Author: Baumann, H|Wang, Y|Morella, K K|Lai, C F|Dams, H|Hilton, D J|Hawley, R G|Mackiewicz, A
PMID: 8683127
Journal: J Biol Chem. 1998 Sep 25;273(39):25510-5.
Title: HBx protein of hepatitis B virus activates Jak1-STAT signaling.
Author: Lee, Y H|Yun, Y
PMID: 9738022
Journal: J Immunol. 1999 Dec 15;163(12):6651-8.
Title: Contributions of leukemia inhibitory factor receptor and oncostatin M receptor to signal transduction in heterodimeric complexes with glycoprotein 130.
Author: Hermanns, H M|Radtke, S|Haan, C|Schmitz-Van de Leur, H|Tavernier, J|Heinrich, P C|Behrmann, I
PMID: 10586060
Journal: Hunan Yi Ke Da Xue Xue Bao. 2001 Feb 28;26(1):17-9.
Title: [Effects of Stat3 phosphorylation and expression of c-fos and c-jun proteins on hepatocarcinogenesis].
Author: Feng, D Y|Zheng, H|Jiang, H Y
PMID: 12536605
Journal: J Exp Med. 2002 Sep 2;196(5):641-53.
Title: Activation of STAT3 by the hepatitis C virus core protein leads to cellular transformation.
Author: Yoshida, Takafumi|Hanada, Toshikatsu|Tokuhisa, Takeshi|Kosai, Ken-ichiro|Sata, Michio|Kohara, Michinori|Yoshimura, Akihiko
PMID: 12208879
Journal: Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1016-21.
Title: Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2.
Author: Leung, K C|Doyle, N|Ballesteros, M|Sjogren, K|Watts, C K W|Low, T H|Leong, G M|Ross, R J M|Ho, K K Y
PMID: 12552091
Journal: Hepatology. 2003 Aug;38(2):314-25.
Title: A common set of immediate-early response genes in liver regeneration and hyperplasia.
Author: Locker, Joseph|Tian, Jianmin|Carver, Robert|Concas, Danilo|Cossu, Costanza|Ledda-Columbano, Giovanna M|Columbano, Amedeo
PMID: 12883475
Journal: FEBS Lett. 2003 Dec 18;555(3):528-32.
Title: Expression of hepatitis C virus non-structural 5A protein in the liver of transgenic mice.
Author: Majumder, Mainak|Steele, Robert|Ghosh, Asish K|Zhou, Xiao Yan|Thornburg, Larry|Ray, Ranjit|Phillips, Nancy J|Ray, Ratna B
PMID: 14675768
Journal: Clin Cancer Res. 2004 Feb 1;10(3):1130-40.
Title: Effects of acyclic retinoid on growth, cell cycle control, epidermal growth factor receptor signaling, and gene expression in human squamous cell carcinoma cells.
Author: Shimizu, Masahito|Suzui, Masumi|Deguchi, Atsuko|Lim, Jin T E|Weinstein, I Bernard
PMID: 14871993
Journal: Virology. 2004 Apr 25;322(1):51-60.
Title: Hepatitis C virus NS5A mediated STAT3 activation requires co-operation of Jak1 kinase.
Author: Sarcar, Bhaswati|Ghosh, Asish K|Steele, Robert|Ray, Ranjit|Ray, Ratna B
PMID: 15063116
Journal: Hepatology. 2004 May;39(5):1332-42.
Title: Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation.
Author: Radaeva, Svetlana|Sun, Rui|Pan, Hong-Na|Hong, Feng|Gao, Bin
PMID: 15122762
Journal: Br J Cancer. 2004 Oct 4;91(7):1335-41.
Title: Constitutional activation of IL-6-mediated JAK/STAT pathway through hypermethylation of SOCS-1 in human gastric cancer cell line.
Author: To, K F|Chan, M W Y|Leung, W K|Ng, E K W|Yu, J|Bai, A H C|Lo, A W I|Chu, S H|Tong, J H M|Lo, K W|Sung, J J Y|Chan, F K L
PMID: 15354212
Journal: J Biol Chem. 2005 Feb 25;280(8):6409-15.
Title: Des-gamma-carboxy prothrombin is a potential autologous growth factor for hepatocellular carcinoma.
Author: Suzuki, Mayumi|Shiraha, Hidenori|Fujikawa, Tatsuya|Takaoka, Nobuyuki|Ueda, Naoki|Nakanishi, Yutaka|Koike, Kazuko|Takaki, Akinobu|Shiratori, Yasushi
PMID: 15582995
Journal: Liver Int. 2005 Apr;25(2):445-57.
Title: Interleukin-6 inhibits cell proliferation in a rat model of hepatocellular carcinoma.
Author: Moran, Diarmuid M|Mayes, Nicholas|Koniaris, Leonidas G|Cahill, Paul A|McKillop, Iain H
PMID: 15780071
Journal: Oncogene. 2005 Sep 22;24(42):6406-17.
Title: Methylation silencing of SOCS-3 promotes cell growth and migration by enhancing JAK/STAT and FAK signalings in human hepatocellular carcinoma.
Author: Niwa, Yasuharu|Kanda, Hiroaki|Shikauchi, Yuko|Saiura, Akio|Matsubara, Kenichi|Kitagawa, Tomoyuki|Yamamoto, Junji|Kubo, Takahiko|Yoshikawa, Hirohide
PMID: 16007195
Journal: Gastroenterology. 2005 Jul;129(1):285-302.
Title: Epidermal growth factor receptor: a novel target of the Wnt/beta-catenin pathway in liver.
Author: Tan, Xinping|Apte, Udayan|Micsenyi, Amanda|Kotsagrelos, Emorphia|Luo, Jian-Hua|Ranganathan, Sarangarajan|Monga, Dulabh K|Bell, Aaron|Michalopoulos, George K|Monga, Satdarshan P S
PMID: 16012954
Journal: Gastroenterology. 2005 Nov;129(5):1616-32.
Title: STAT3 NH2-terminal acetylation is activated by the hepatic acute-phase response and required for IL-6 induction of angiotensinogen.
Author: Ray, Sutapa|Boldogh, Istvan|Brasier, Allan R
PMID: 16285960
Journal: Oncogene. 2006 Apr 20;25(17):2520-30.
Title: Loss of SOCS3 in the liver promotes fibrosis by enhancing STAT3-mediated TGF-beta1 production.
Author: Ogata, H|Chinen, T|Yoshida, T|Kinjyo, I|Takaesu, G|Shiraishi, H|Iida, M|Kobayashi, T|Yoshimura, A
PMID: 16474852
Journal: Ai Zheng. 2006 Mar;25(3):269-74.
Title: [Effects of STAT3 antisense oligodeoxynucleotides on apoptosis and proliferation of mouse melanoma cell line B16].
Author: Tang, Gu-Sheng|Cai, Jian-Ming|Ni, Jin|Xiang, Ying-Song|Cui, Jian-Guo|Zhu, Dan|Dong, Jun-Rui
PMID: 16536977
Journal: Virology. 2006 Jun 5;349(2):347-58.
Title: Microarray analyses and molecular profiling of Stat3 signaling pathway induced by hepatitis C virus core protein in human hepatocytes.
Author: Basu, Arnab|Meyer, Keith|Lai, Keith K|Saito, Kousuke|Di Bisceglie, Adrian M|Grosso, Leonard E|Ray, Ratna B|Ray, Ranjit
PMID: 16545852
Journal: Biochem J. 2006 Sep 15;398(3):577-83.
Title: Functional expression of a biologically active fragment of soluble gp130 as an ELP-fusion protein in transgenic plants: purification via inverse transition cycling.
Author: Lin, Meng|Rose-John, Stefan|Grotzinger, Joachim|Conrad, Udo|Scheller, Jurgen
PMID: 16716147
Journal: World J Gastroenterol. 2006 Jun 14;12(22):3512-22.
Title: Biliary wound healing, ductular reactions, and IL-6/gp130 signaling in the development of liver disease.
Author: Demetris, A-J|Lunz, John-G 3rd|Specht, Susan|Nozaki, Isao
PMID: 16773708
Journal: Gastroenterology. 2006 Jul;131(1):179-93.
Title: Deletion of the SOCS3 gene in liver parenchymal cells promotes hepatitis-induced hepatocarcinogenesis.
Author: Ogata, Hisanobu|Kobayashi, Takashi|Chinen, Takatoshi|Takaki, Hiromi|Sanada, Takahito|Minoda, Yasumasa|Koga, Keiko|Takaesu, Giichi|Maehara, Yoshihiko|Iida, Mitsuo|Yoshimura, Akihiko
PMID: 16831601
Journal: Zhonghua Wei Chang Wai Ke Za Zhi. 2006 Jul;9(4):349-51.
Title: [Relationship of hypoxia-induced factor with tumor angiogenesis in early liver metastasis in colonic cancer].
Author: Liang, Hao-hui|Wang, Cheng-you|Xu, Min|Cheng, Shu-bang
PMID: 16886122
Journal: Hepatology. 2006 Oct;44(4):936-44.
Title: HCV core expression in hepatocytes protects against autoimmune liver injury and promotes liver regeneration in mice.
Author: Kawamura, Hiroki|Govindarajan, Sugantha|Aswad, Fred|Machida, Keigo|Lai, Michael M C|Sung, Vicky M-H|Dennert, Gunther
PMID: 17006910
Journal: Biochem Biophys Res Commun. 2006 Dec 8;351(1):253-8.
Title: The interaction of hepatitis B virus X protein and protein phosphatase type 2 Calpha and its effect on IL-6.
Author: Kim, Ji Su|Rho, Bo young|Lee, Tae Ho|Lee, Jae Myun|Kim, Se Jong|Park, Jeon Han
PMID: 17055456
Journal: Cell Transplant. 2006;15(8-9):785-98.
Title: Microencapsulation of engineered cells to deliver sustained high circulating levels of interleukin-6 to study hepatocellular carcinoma progression.
Author: Moran, Diarmuid M|Koniaris, Leonidas G|Jablonski, Elizabeth M|Cahill, Paul A|Halberstadt, Craig R|McKillop, Iain H
PMID: 17269449
Journal: J Clin Pathol. 2007 Jun;60(6):642-8.
Title: Altered p-STAT3 (tyr705) expression is associated with histological grading and intratumour microvessel density in hepatocellular carcinoma.
Author: Yang, Sheau-Fang|Wang, Shen-Nien|Wu, Chih-Fung|Yeh, Yao-Tsung|Chai, Chee-Yin|Chunag, Shih-Chang|Sheen, Maw-Chang|Lee, King-Teh
PMID: 16901975
Journal: Oncogene. 2007 Mar 22;26(13):1941-8.
Title: Expression of SOCS1 and SOCS3 genes is differentially regulated in breast cancer cells in response to proinflammatory cytokine and growth factor signals.
Author: Evans, M K|Yu, C-R|Lohani, A|Mahdi, R M|Liu, X|Trzeciak, A R|Egwuagu, C E
PMID: 17001312
Journal: J Cancer Res Clin Oncol. 2007 Mar;133(3):145-52.
Title: Roles of EGFR-Stat3 signal pathway in carcinogenesis of experimental hepatoma in rats.
Author: Yu, Xiao Tang|Zhu, Shi Neng|Xu, Zu De|Hu, Xi Qi|Zhu, Teng Fang|Chen, Jie Qing|Lu, Shi Lun
PMID: 17031671
Journal: Braz J Med Biol Res. 2007 May;40(5):621-31.
Title: TIMP-1 mediates the inhibitory effect of interleukin-6 on the proliferation of a hepatocarcinoma cell line in a STAT3-dependent manner.
Author: Guo, S-Y|Shen, X|Yang, J|Yuan, J|Yang, R-L|Mao, K|Zhao, D-H|Li, C-J
PMID: 17464423
Journal: Cancer Biol Ther. 2007 Dec;6(12):1900-7. Epub 2007 Sep 1.
Title: Inhibition of Stat3 activity by YC-1 enhances chemo-sensitivity in hepatocellular carcinoma.
Author: Lau, Chi Keung|Yang, Zhen Fan|Lam, Shuk Pik|Lam, Chi Tat|Ngai, Patricia|Tam, Ka Ho|Poon, Ronnie Tung-Ping|Fan, Sheung Tat
PMID: 18059167
Journal: J Surg Res. 2008 Jun 1;147(1):23-33.
Title: Interleukin-6 mediates G(0)/G(1) growth arrest in hepatocellular carcinoma through a STAT 3-dependent pathway.
Author: Moran, Dairmuid M|Mattocks, M Adrian|Cahill, Paul A|Koniaris, Leonidas G|McKillop, Iain H
PMID: 17574577
Journal: J Cancer Res Clin Oncol. 2008 May;134(5):551-9.
Title: Stat3 up-regulates expression of nicotinamide N-methyltransferase in human cancer cells.
Author: Tomida, Mikio|Ohtake, Hideki|Yokota, Takashi|Kobayashi, Yasuhito|Kurosumi, Masafumi
PMID: 17922140
Journal: Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2445-50.
Title: Progenitor/stem cells give rise to liver cancer due to aberrant TGF-beta and IL-6 signaling.
Author: Tang, Yi|Kitisin, Krit|Jogunoori, Wilma|Li, Cuiling|Deng, Chu-Xia|Mueller, Susette C|Ressom, Habtom W|Rashid, Asif|He, Aiwu Ruth|Mendelson, Jonathan S|Jessup, John M|Shetty, Kirti|Zasloff, Michael|Mishra, Bibhuti|Reddy, E P|Johnson, Lynt|Mishra, Lopa
PMID: 18263735
Journal: Langenbecks Arch Surg. 2008 May;393(3):333-41.
Title: Dual inhibition of Raf and VEGFR2 reduces growth and vascularization of hepatocellular carcinoma in an experimental model.
Author: Lang, Sven Arke|Brecht, Isabel|Moser, Christian|Obed, Aiman|Batt, David|Schlitt, Hans Juergen|Geissler, Edward Kenneth|Stoeltzing, Oliver
PMID: 18297306
Journal: Clin Cancer Res. 2008 May 1;14(9):2806-12.
Title: Synergistic growth inhibition by 9-cis-retinoic acid plus trastuzumab in human hepatocellular carcinoma cells.
Author: Tatebe, Hideharu|Shimizu, Masahito|Shirakami, Yohei|Tsurumi, Hisashi|Moriwaki, Hisataka
PMID: 18451248
Journal: Hepatol Res. 2008 Jun;38(6):601-13.
Title: Angiotensin II and epidermal growth factor receptor cross-talk mediated by a disintegrin and metalloprotease accelerates tumor cell proliferation of hepatocellular carcinoma cell lines.
Author: Itabashi, Hidenori|Maesawa, Chihaya|Oikawa, Hiroki|Kotani, Koji|Sakurai, Eiichi|Kato, Kuniyuki|Komatsu, Hideaki|Nitta, Hiroyuki|Kawamura, Hidenobu|Wakabayashi, Go|Masuda, Tomoyuki
PMID: 18452483
Journal: BMC Cancer. 2008 Jul 23;8:206.
Title: ENMD-1198, a novel tubulin-binding agent reduces HIF-1alpha and STAT3 activity in human hepatocellular carcinoma(HCC) cells, and inhibits growth and vascularization in vivo.
Author: Moser, Christian|Lang, Sven A|Mori, Akira|Hellerbrand, Claus|Schlitt, Hans J|Geissler, Edward K|Fogler, William E|Stoeltzing, Oliver
PMID: 18651980
Journal: J Virol. 2008 Nov;82(22):11066-72.
Title: Hepatitis C virus core protein augments androgen receptor-mediated signaling.
Author: Kanda, Tatsuo|Steele, Robert|Ray, Ranjit|Ray, Ratna B
PMID: 18768969
Journal: Cell Cycle. 2008 Oct;7(20):3202-10.
Title: Epigenetic downregulation of the suppressor of cytokine signaling 1 (Socs1) gene is associated with the STAT3 activation and development of hepatocellular carcinoma induced by methyl-deficiency in rats.
Author: Bagnyukova, Tetyana V|Tryndyak, Volodymyr P|Muskhelishvili, Levan|Ross, Sharon A|Beland, Frederick A|Pogribny, Igor P
PMID: 18843197
Journal: Intervirology. 2008;51(6):432-43.
Title: Subcellular mislocalization of mutant hepatitis B X proteins contributes to modulation of STAT/SOCS signaling in hepatocellular carcinoma.
Author: Bock, C-Thomas|Toan, Nguyen L|Koeberlein, Bernd|Song, Le H|Chin, Ruth|Zentgraf, Hanswalter|Kandolf, Reinhard|Torresi, Joseph
PMID: 19321929
Journal: Gastrointest Cancer Res. 2008 Jul;2(4 Suppl):S27-30.
Title: Liver stem cells and tgf-Beta in hepatic carcinogenesis.
Author: Amin, Rupen|Mishra, Lopa
PMID: 19343145
Journal: Cancer Res Treat. 2008 Jun;40(2):53-61.
Title: Cytoplasmic trapping of CXCR4 in hepatocellular carcinoma cell lines.
Author: Kim, Seong-Woo|Kim, Ha-Yon|Song, Ik-Chan|Jin, Seon-Ah|Lee, Hyo-Jin|Yun, Hwan-Jung|Kim, Samyong|Jo, Deog-Yeon
PMID: 19688049
Journal: Cancer Chemother Pharmacol. 2009 Mar;63(4):635-42.
Title: Targeted constitutive activation of signal transducer and activator of transcription 3 in human hepatocellular carcinoma cells by cucurbitacin B.
Author: Zhang, Meixia|Zhang, Hongliang|Sun, Chunyan|Shan, Xiaolei|Yang, Xiaolin|Li-Ling, Jesse|Deng, Yihui
PMID: 18521604
Journal: Oncogene. 2009 Feb 5;28(5):638-50.
Title: ILEI requires oncogenic Ras for the epithelial to mesenchymal transition of hepatocytes and liver carcinoma progression.
Author: Lahsnig, C|Mikula, M|Petz, M|Zulehner, G|Schneller, D|van Zijl, F|Huber, H|Csiszar, A|Beug, H|Mikulits, W
PMID: 19015638
Journal: Ann N Y Acad Sci. 2009 Feb;1155:206-21.
Title: Inflammation and liver cancer: new molecular links .
Author: Berasain, C|Castillo, J|Perugorria, M J|Latasa, M U|Prieto, J|Avila, M A
PMID: 19250206
Journal: J Biol Chem. 2009 May 15;284(20):13335-47.
Title: Specific expression and regulation of hepassocin in the liver and down-regulation of the correlation of HNF1alpha with decreased levels of hepassocin in human hepatocellular carcinoma.
Author: Yu, Hai-Tao|Yu, Miao|Li, Chang-Yan|Zhan, Yi-Qun|Xu, Wang-Xiang|Li, Yong-Hui|Li, Wei|Wang, Zhi-Dong|Ge, Chang-Hui|Yang, Xiao-Ming
PMID: 19304666
Journal: J Exp Med. 2009 Apr 13;206(4):819-31.
Title: Loss of STAT5 causes liver fibrosis and cancer development through increased TGF-{beta} and STAT3 activation.
Author: Hosui, Atsushi|Kimura, Akiko|Yamaji, Daisuke|Zhu, Bing-mei|Na, Risu|Hennighausen, Lothar
PMID: 19332876
Journal: J Proteome Res. 2009 Aug;8(8):3977-86.
Title: Identifying apoptosis-evasion proteins/pathways in human hepatoma cells via induction of cellular hormesis by UV irradiation.
Author: Hsieh, Sen-Yung|Hsu, Chih-Yun|He, Jung-Ru|Liu, Chiung-Liang|Lo, Shao-Jung|Chen, Ying-Ching|Huang, Hui-Yu
PMID: 19545154
Journal: J Pathol. 2009 Oct;219(2):253-62.
Title: Non-structural 5A protein of hepatitis C virus induces a range of liver pathology in transgenic mice.
Author: Wang, Ai-Guo|Lee, Dong-Seok|Moon, Hyung-Bae|Kim, Jin-Man|Cho, Kyung-Hyun|Choi, Soo-Ho|Ha, Hye-Lin|Han, Ying-Hao|Kim, Dae-Ghon|Hwang, Soon B|Yu, Dae-Yeul
PMID: 19621337
Journal: Cancer Biol Ther. 2009 Sep;8(18):1691-8.
Title: Cancer stem cells and hepatocellular carcinoma.
Author: Yao, Zhixing|Mishra, Lopa
PMID: 19901516
Journal: Int J Cancer. 2010 Mar 1;126(5):1263-74.
Title: High expression levels of IKKalpha and IKKbeta are necessary for the malignant properties of liver cancer.
Author: Jiang, Runqiu|Xia, Yongxiang|Li, Jun|Deng, Lei|Zhao, Liang|Shi, Jian|Wang, Xuehao|Sun, Beicheng
PMID: 19728335
Journal: Cytokine Growth Factor Rev. 2010 Feb;21(1):11-9.
Title: Dangerous liaisons: STAT3 and NF-kappaB collaboration and crosstalk in cancer.
Author: Grivennikov, Sergei I|Karin, Michael
PMID: 20018552
Journal: J Endocrinol. 2010 Mar;204(3):299-309.
Title: GH modulates hepatic epidermal growth factor signaling in the mouse.
Author: Gonzalez, Lorena|Diaz, Ma Eugenia|Miquet, Johanna G|Sotelo, Ana I|Fernandez, Diego|Dominici, Fernando P|Bartke, Andrzej|Turyn, Daniel
PMID: 20032199
Journal: Cancer Lett. 2010 Jun 28;292(2):197-207.
Title: Diosgenin, a steroidal saponin, inhibits STAT3 signaling pathway leading to suppression of proliferation and chemosensitization of human hepatocellular carcinoma cells.
Author: Li, Feng|Fernandez, Prasana Priscilla|Rajendran, Peramaiyan|Hui, Kam M|Sethi, Gautam
PMID: 20053498
Journal: Histol Histopathol. 2010 Mar;25(3):299-307.
Title: Survivin overexpression in HCC and liver cirrhosis differentially correlates with p-STAT3 and E-cadherin.
Author: Peroukides, Stavros|Bravou, Vasiliki|Alexopoulos, Alexandros|Varakis, John|Kalofonos, Haralabos|Papadaki, Helen
PMID: 20054802
Journal: Cell. 2010 Jan 22;140(2):197-208.
Title: Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression.
Author: Park, Eek Joong|Lee, Jun Hee|Yu, Guann-Yi|He, Guobin|Ali, Syed Raza|Holzer, Ryan G|Osterreicher, Christoph H|Takahashi, Hiroyuki|Karin, Michael
PMID: 20141834
Journal: Cancer Lett. 2010 Aug 1;294(1):118-24.
Title: Cucurbitacin B induces apoptosis and S phase cell cycle arrest in BEL-7402 human hepatocellular carcinoma cells and is effective via oral administration.
Author: Chan, Kin Tak|Meng, Fan Yan|Li, Qian|Ho, Cheong Yip|Lam, Tsz Shan|To, Yu|Lee, Wai Him|Li, Miao|Chu, Kee Hung|Toh, Melvin
PMID: 20153103
Journal: Cancer Biother Radiopharm. 2010 Feb;25(1):81-8.
Title: Antitumor activity of the aqueous extract from Sedum sarmentosum Bunge in vitro.
Author: Huang, Dandan|Zhang, Weiyun|Huang, Danqing|Wu, Jianyong
PMID: 20187800
Journal: Cancer Cell. 2010 Mar 16;17(3):286-97.
Title: Hepatocyte IKKbeta/NF-kappaB inhibits tumor promotion and progression by preventing oxidative stress-driven STAT3 activation.
Author: He, Guobin|Yu, Guann-Yi|Temkin, Vladislav|Ogata, Hisanobu|Kuntzen, Christian|Sakurai, Toshiharu|Sieghart, Wolfgang|Peck-Radosavljevic, Markus|Leffert, Hyam L|Karin, Michael
PMID: 20227042
Journal: Eur J Gastroenterol Hepatol. 2010 Sep;22(9):1106-10.
Title: Tolerance and outcome of patients with unresectable hepatocellular carcinoma treated with sorafenib.
Author: Ozenne, Violaine|Paradis, Valerie|Pernot, Simon|Castelnau, Corinne|Vullierme, Marie-Pierre|Bouattour, Mohamed|Valla, Dominique|Farges, Olivier|Degos, Francoise
PMID: 20300004
Journal: PLoS One. 2010 Mar 23;5(3):e8649.
Title: Hepatitis B virus X protein impairs hepatic insulin signaling through degradation of IRS1 and induction of SOCS3.
Author: Kim, KyeongJin|Kim, Kook Hwan|Cheong, JaeHun
PMID: 20351777
Journal: Mol Cell Biochem. 2010 Oct;343(1-2):155-62.
Title: Expression of Oct4 in HCC and modulation to wnt/beta-catenin and TGF-beta signal pathways.
Author: Yuan, FangJun|Zhou, Wenbo|Zou, Can|Zhang, Zhiyun|Hu, Hongsheng|Dai, Zongqing|Zhang, YouShun
PMID: 20549546
Journal: J Biol Chem. 2010 Aug 27;285(35):27429-39.
Title: Inhibition of STAT3 signaling blocks the anti-apoptotic activity of IL-6 in human liver cancer cells.
Author: Liu, Yan|Li, Pui-Kai|Li, Chenglong|Lin, Jiayuh
PMID: 20562100
Journal: Int J Mol Med. 2010 Aug;26(2):185-91.
Title: Suppression of cell death by the secretory form of N-terminal ERC/mesothelin.
Author: Wang, Tegexibaiyin|Kajino, Kazunori|Abe, Masaaki|Tan, Ke|Maruo, Masumi|Sun, Guodong|Hagiwara, Yoshiaki|Maeda, Masahiro|Hino, Okio
PMID: 20596597
Journal: Aliment Pharmacol Ther. 2010 Jul;32(2):304-5.
Title: Role of IL-6 activated STAT3 and TNF expression in obesity-associated hepatocellular carcinoma.
Author: Beyazit, Y|Kekilli, M|Kurt, M|Sayilir, A|Tas, A|Onal, I K
PMID: 20636625
Journal: Hepatology. 2010 Aug;52(2):480-92.
Title: c-Jun mediates hepatitis C virus hepatocarcinogenesis through signal transducer and activator of transcription 3 and nitric oxide-dependent impairment of oxidative DNA repair.
Author: Machida, Keigo|Tsukamoto, Hidekazu|Liu, Jian-Chang|Han, Yuan-Ping|Govindarajan, Sugantha|Lai, Michael M C|Akira, Shizuo|Ou, Jing-Hsiung James
PMID: 20683948
Journal: BMC Cancer. 2010 Aug 19;10:442.
Title: Leptin as a critical regulator of hepatocellular carcinoma development through modulation of human telomerase reverse transcriptase.
Author: Stefanou, Nikolaos|Papanikolaou, Vassilis|Furukawa, Yoichi|Nakamura, Yusuke|Tsezou, Aspasia
PMID: 20723213
Journal: Oncol Rep. 2010 Oct;24(4):1093-9.
Title: beta-catenin siRNA regulation of apoptosis- and angiogenesis-related gene expression in hepatocellular carcinoma cells: potential uses for gene therapy.
Author: Wang, Xin-Hong|Sun, Xun|Meng, Xiang-Wei|Lv, Zhi-Wu|Du, Ya-Ju|Zhu, Yan|Chen, Jing|Kong, De-Xia|Jin, Shi-Zhu
PMID: 20811694
Journal: Clin Cancer Res. 2010 Nov 1;16(21):5189-99.
Title: Sorafenib overcomes TRAIL resistance of hepatocellular carcinoma cells through the inhibition of STAT3.
Author: Chen, Kuen-Feng|Tai, Wei-Tien|Liu, Tsung-Hao|Huang, Hsiang-Po|Lin, Yu-Chin|Shiau, Chung-Wai|Li, Pui-Kai|Chen, Pei-Jer|Cheng, Ann-Lii
PMID: 20884624
Journal: Oncol Res. 2010;18(11-12):561-74.
Title: Ad.mda-7 (IL-24) selectively induces apoptosis in hepatocellular carcinoma cell lines, suppresses metastasis, and enhances the effect of doxorubicin on xenograft tumors.
Author: Wang, Cong-Jun|Zhang, Hui|Chen, Kun|Zheng, Jian-Wei|Xiao, Chao-Wen|Ji, Wen-Wei|Yu, Yuan|Hu, Hui-Yi|Li, Yan|Xue, Xin-Bo
PMID: 20939432
Journal: Hepatology. 2010 Nov;52(5):1713-22.
Title: Adiponectin antagonizes the oncogenic actions of leptin in hepatocellular carcinogenesis.
Author: Sharma, Dipali|Wang, Jason|Fu, Ping P|Sharma, Shvetank|Nagalingam, Arumugam|Mells, Jamie|Handy, Jeffrey|Page, Andrew J|Cohen, Cynthia|Anania, Frank A|Saxena, Neeraj K
PMID: 20941777
Journal: Zhonghua Gan Zang Bing Za Zhi. 2010 Sep;18(9):672-5.
Title: [The role and significance of Wnt/beta-catenin signaling pathway regulating the signaling molecules in hepatocellular carcinoma].
Author: Wang, Xin-hong|Sun, Xun|Meng, Xiang-wei|Lu, Zhi-wu|Liu, Min-na|Pei, Feng-hua
PMID: 20943078
Journal: Clin Cancer Res. 2011 Mar 15;17(6):1425-39.
Title: Suppression of signal transducer and activator of transcription 3 activation by butein inhibits growth of human hepatocellular carcinoma in vivo.
Author: Rajendran, Peramaiyan|Ong, Tina H|Chen, Luxi|Li, Feng|Shanmugam, Muthu K|Vali, Shireen|Abbasi, Taher|Kapoor, Shweta|Sharma, Ashish|Kumar, Alan Prem|Hui, Kam M|Sethi, Gautam
PMID: 21131551
Journal: Cell Res. 2011 Jan;21(1):159-68.
Title: NF-kappaB and STAT3 - key players in liver inflammation and cancer.
Author: He, Guobin|Karin, Michael
PMID: 21187858
Journal: Neoplasma. 2011;58(2):158-71.
Title: Silencing STAT3 may inhibit cell growth through regulating signaling pathway, telomerase, cell cycle, apoptosis and angiogenesis in hepatocellular carcinoma: potential uses for gene therapy.
Author: Wang, X H|Liu, B R|Qu, B|Xing, H|Gao, S L|Yin, J M|Wang, X F|Cheng, Y Q
PMID: 21275467
Journal: J Biol Chem. 2011 Mar 25;286(12):10847-55.
Title: Extracellular hepatitis C virus core protein activates STAT3 in human monocytes/macrophages/dendritic cells via an IL-6 autocrine pathway.
Author: Tacke, Robert S|Tosello-Trampont, Annie|Nguyen, Virginia|Mullins, David W|Hahn, Young S
PMID: 21282107
Journal: Future Oncol. 2011 Feb;7(2):161-4.
Title: Blocking the IL-6-STAT3 signaling pathway: potential liver cancer therapy.
Author: Liu, Yan|Lin, Jiayuh
PMID: 21345134
Journal: Cancer Prev Res (Phila). 2011 Mar;4(3):396-403.
Title: Preventive effects of (-)-epigallocatechin gallate on diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/KsJ-db/db Mice.
Author: Shimizu, Masahito|Sakai, Hiroyasu|Shirakami, Yohei|Yasuda, Yoichi|Kubota, Masaya|Terakura, Daishi|Baba, Atsushi|Ohno, Tomohiko|Hara, Yukihiko|Tanaka, Takuji|Moriwaki, Hisataka
PMID: 21372039
Journal: Int J Oncol. 2011 May;38(5):1395-402.
Title: Regulation of cancer cell proliferation by caveolin-2 down-regulation and re-expression.
Author: Lee, Sangho|Kwon, Hayeong|Jeong, Kyuho|Pak, Yunbae
PMID: 21373752
Journal: J Cell Physiol. 2011 Jun;226(6):1632-41.
Title: Parthenolide sensitizes hepatocellular carcinoma cells to TRAIL by inducing the expression of death receptors through inhibition of STAT3 activation.
Author: Carlisi, Daniela|D'Anneo, Antonella|Angileri, Liliana|Lauricella, Marianna|Emanuele, Sonia|Santulli, Andrea|Vento, Renza|Tesoriere, Giovanni
PMID: 21413021
Journal: HPB (Oxford). 2011 Apr;13(4):225-33.
Title: Leptin inhibits hepatocellular carcinoma proliferation via p38-MAPK-dependent signalling.
Author: Thompson, Kyle J|Lau, Kwan N|Johnson, Sarah|Martinie, John B|Iannitti, David A|McKillop, Iain H|Sindram, David
PMID: 21418127
Journal: Cancer Prev Res (Phila). 2011 Aug;4(8):1296-305.
Title: Celecoxib inhibits interleukin-6/interleukin-6 receptor-induced JAK2/STAT3 phosphorylation in human hepatocellular carcinoma cells.
Author: Liu, Yan|Liu, Aiguo|Li, Huameng|Li, Chenglong|Lin, Jiayuh
PMID: 21490132
Journal: Oncogene. 2011 Sep 8;30(36):3887-99.
Title: Pleiotropic regulation of macrophage polarization and tumorigenesis by formyl peptide receptor-2.
Author: Li, Y|Cai, L|Wang, H|Wu, P|Gu, W|Chen, Y|Hao, H|Tang, K|Yi, P|Liu, M|Miao, S|Ye, D
PMID: 21499310
Journal: Cancer Cell. 2011 May 17;19(5):629-39.
Title: Ptpn11/Shp2 acts as a tumor suppressor in hepatocellular carcinogenesis.
Author: Bard-Chapeau, Emilie A|Li, Shuangwei|Ding, Jin|Zhang, Sharon S|Zhu, Helen H|Princen, Frederic|Fang, Diane D|Han, Tao|Bailly-Maitre, Beatrice|Poli, Valeria|Varki, Nissi M|Wang, Hongyang|Feng, Gen-Sheng
PMID: 21575863
Journal: Front Biosci (Landmark Ed). 2011 Jun 1;16:2794-811.
Title: JAK-STAT signaling in hepatic fibrosis.
Author: Mair, Markus|Blaas, Leander|Osterreicher, Christoph H|Casanova, Emilio|Eferl, Robert
PMID: 21622209
Journal: Hepatogastroenterology. 2011 Mar-Apr;58(106):487-91.
Title: STAT3 and beta-catenin signaling pathway may affect GSK-3beta expression in hepatocellular carcinoma.
Author: Wang, Xin-Hong|Meng, Xiang-Wei|Xing, Hui|Qu, Bo|Han, Ming-Zi|Chen, Jing|Fan, Yu-Jing|Lu, Cheng-Qian|Lu, Zhi-Wu
PMID: 21661417
Journal: Hepatology. 2011 Sep 2;54(3):900-9.
Title: Interleukin-22 promotes human hepatocellular carcinoma by activation of STAT3.
Author: Jiang, Runqiu|Tan, Zhongming|Deng, Lei|Chen, Yun|Xia, Yongxiang|Gao, Yun|Wang, Xuehao|Sun, Beicheng
PMID: 21674558
Journal: Am J Pathol. 2011 Aug;179(2):714-24.
Title: Hepatoprotective versus oncogenic functions of STAT3 in liver tumorigenesis.
Author: Wang, Hua|Lafdil, Fouad|Wang, Lei|Park, Ogyi|Yin, Shi|Niu, Junyang|Miller, Andrew M|Sun, Zhaoli|Gao, Bin
PMID: 21684247
Journal: J Hepatol. 2011 Nov;55(5):957-9.
Title: Targeting STAT3 in hepatocellular carcinoma: sorafenib again....
Author: Rosmorduc, Olivier|Desbois-Mouthon, Christele
PMID: 21718664
Journal: Hepatology. 2011 Oct;54(4):1398-409.
Title: Impairment of hepatic growth hormone and glucocorticoid receptor signaling causes steatosis and hepatocellular carcinoma in mice.
Author: Mueller, Kristina M|Kornfeld, Jan-Wilhelm|Friedbichler, Katrin|Blaas, Leander|Egger, Gerda|Esterbauer, Harald|Hasselblatt, Peter|Schlederer, Michaela|Haindl, Susanne|Wagner, Kay-Uwe|Engblom, David|Haemmerle, Guenter|Kratky, Dagmar|Sexl, Veronika|Kenner, L
PMID: 21725989
Journal: Cell Stem Cell. 2011 Jul 8;9(1):50-63.
Title: CD24(+) liver tumor-initiating cells drive self-renewal and tumor initiation through STAT3-mediated NANOG regulation.
Author: Lee, Terence Kin Wah|Castilho, Antonia|Cheung, Vincent Chi Ho|Tang, Kwan Ho|Ma, Stephanie|Ng, Irene Oi Lin
PMID: 21726833
Journal: Genes Cancer. 2011 Jan;2(1):3-9.
Title: Context-Specific Growth Hormone Signaling through the Transcription Factor STAT5: Implications for the Etiology of Hepatosteatosis and Hepatocellular Carcinoma.
Author: Yoo, Kyung Hyun|Baik, Myunggi|Hennighausen, Lothar
PMID: 21779476
Journal: Acta Biochim Biophys Sin (Shanghai). 2011 Oct;43(10):813-21.
Title: Cancer targeting gene-viro-therapy specific for liver cancer by alpha-fetoprotein-controlled oncolytic adenovirus expression of SOCS3 and IL-24.
Author: Cao, Xin|Wei, Ruicheng|Liu, Xinran|Zeng, Yan|Huang, Hongling|Ding, Miao|Zhang, Kangjian|Liu, Xin-Yuan
PMID: 21835849
Journal: Toxicol Pathol. 2011 Dec;39(7):1084-90.
Title: Roles for rat hepatocyte malignant transforming factor (HMTF) in late stage of hepatocarcinogenesis.
Author: Suzuki, Shugo|Pitchakarn, Pornsiri|Takeshita, Kentaro|Asamoto, Makoto|Takahashi, Satoru|Sato, Shinya|Shirai, Tomoyuki
PMID: 21934139
Journal: Liver Int. 2011 Nov;31(10):1494-504.
Title: Clinicopathological and prognostic significance of serum and tissue Dickkopf-1 levels in human hepatocellular carcinoma.
Author: Tung, Edmund Kwok-Kwan|Mak, Carmen Ka-Man|Fatima, Sarwat|Lo, Regina Cheuk-Lam|Zhao, Heng|Zhang, Chunsheng|Dai, Hongyue|Poon, Ronnie Tung-Ping|Yuen, Man-Fung|Lai, Ching-Lung|Li, Jin-jun|Luk, John Moon-Ching|Ng, Irene Oi-Lin
PMID: 21955977
Journal: Cell. 2011 Dec 9;147(6):1233-47.
Title: An HNF4alpha-miRNA inflammatory feedback circuit regulates hepatocellular oncogenesis.
Author: Hatziapostolou, Maria|Polytarchou, Christos|Aggelidou, Eleni|Drakaki, Alexandra|Poultsides, George A|Jaeger, Savina A|Ogata, Hisanobu|Karin, Michael|Struhl, Kevin|Hadzopoulou-Cladaras, Margarita|Iliopoulos, Dimitrios
PMID: 22153071
Journal: Mol Cancer. 2011 Dec 15;10:150.
Title: IL-17 induces AKT-dependent IL-6/JAK2/STAT3 activation and tumor progression in hepatocellular carcinoma.
Author: Gu, Fang-Ming|Li, Quan-Lin|Gao, Qiang|Jiang, Jia-Hao|Zhu, Kai|Huang, Xiao-Yong|Pan, Jin-Feng|Yan, Jun|Hu, Jin-Hui|Wang, Zheng|Dai, Zhi|Fan, Jia|Zhou, Jian
PMID: 22171994
Journal: Cancer Cell. 2011 Dec 13;20(6):698-9.
Title: Targeting liver cancer: first steps toward a miRacle?
Author: Schwabe, Robert F|Wang, Timothy C
PMID: 22172719
Journal: Exp Ther Med. 2011 Jul;2(4):647-653.
Title: Prognostic significance of phosphorylated signal transducer and activator of transcription 3 and suppressor of cytokine signaling 3 expression in hepatocellular carcinoma.
Author: Wu, Wen-Yong|Li, Jun|Wu, Zheng-Sheng|Zhang, Chang-LE|Meng, Xiang-Ling|Lobie, Peter E
PMID: 22977555
Journal: Cancer Immunol Immunother. 2012 Jan;61(1):101-8.
Title: Upregulation of B7-H1 expression is associated with macrophage infiltration in hepatocellular carcinomas.
Author: Chen, Jie|Li, Guosheng|Meng, Hong|Fan, Yuchen|Song, Yonghong|Wang, Shurong|Zhu, Faliang|Guo, Chun|Zhang, Lining|Shi, Yongyu
PMID: 21853301
Journal: Hepatology. 2012 Jan;55(1):141-52.
Title: Regression of established hepatocellular carcinoma is induced by chemoimmunotherapy in an orthotopic murine model.
Author: Avella, Diego M|Li, Guangfu|Schell, Todd D|Liu, Dai|Zhang, Samuel Shao-Min|Lou, Xi|Berg, Arthur|Kimchi, Eric T|Tagaram, Hephzibah Rani S|Yang, Qing|Shereef, Serene|Garcia, Luis S|Kester, Mark|Isom, Harriet C|Rountree, C Bart|Staveley-O'Carroll, Kevin F
PMID: 21898502
Journal: Hepatology. 2012 Jan;55(1):108-20.
Title: Hepatitis B virus X (HBx) induces tumorigenicity of hepatic progenitor cells in 3,5-diethoxycarbonyl-1,4-dihydrocollidine-treated HBx transgenic mice.
Author: Wang, Chao|Yang, Wen|Yan, He-Xin|Luo, Tao|Zhang, Jian|Tang, Liang|Wu, Fu-Quan|Zhang, Hui-Lu|Yu, Le-Xing|Zheng, Long-Yi|Li, Yu-Qiong|Dong, Wei|He, Ya-Qin|Liu, Qiong|Zou, Shan-Shan|Lin, Yan|Hu, Liang|Li, Zhong|Wu, Meng-Chao|Wang, Hong-Yang
PMID: 21932402
Journal: Hepatology. 2012 Mar;55(3):941-52.
Title: Growth-hormone-induced signal transducer and activator of transcription 5 signaling causes gigantism, inflammation, and premature death but protects mice from aggressive liver cancer.
Author: Friedbichler, Katrin|Themanns, Madeleine|Mueller, Kristina M|Schlederer, Michaela|Kornfeld, Jan-Wilhelm|Terracciano, Luigi M|Kozlov, Andrey V|Haindl, Susanne|Kenner, Lukas|Kolbe, Thomas|Mueller, Mathias|Snibson, Kenneth J|Heim, Markus H|Moriggl, Richard
PMID: 22031092
Journal: Liver Int. 2012 Jan;32(1):70-7.
Title: NSC 74859-mediated inhibition of STAT3 enhances the anti-proliferative activity of cetuximab in hepatocellular carcinoma.
Author: Chen, Wei|Shen, Xuning|Xia, Xuefeng|Xu, Guodong|Ma, Tao|Bai, Xueli|Liang, Tingbo
PMID: 22098470
Journal: Mol Cancer Ther. 2012 Feb;11(2):452-63.
Title: Dovitinib induces apoptosis and overcomes sorafenib resistance in hepatocellular carcinoma through SHP-1-mediated inhibition of STAT3.
Author: Tai, Wei-Tien|Cheng, Ann-Lii|Shiau, Chung-Wai|Liu, Chun-Yu|Ko, Ching-Huai|Lin, Mai-Wei|Chen, Pei-Jer|Chen, Kuen-Feng
PMID: 22180308
Journal: Hepatology. 2012 Jan;55(1):322-4.
Title: Sh(i)pping signals protect against Stat3-driven liver cancer.
Author: Nevzorova, Yulia A|Liedtke, Christian
PMID: 22190379
Journal: J Cancer Res Clin Oncol. 2012 May;138(5):885-96.
Title: Pseudolaric acid B inhibits inducible cyclooxygenase-2 expression via downregulation of the NF-kappaB pathway in HT-29 cells.
Author: Hou, Li|Xu, Bo|Guo, Wei|Ran, Fu-Xiang|Liu, Jing-Tao|Yuan, Xia|Fu, Hong-Zheng|Cui, Jing-Rong
PMID: 22314698
Journal: Hepatology. 2012 Jul;56(1):186-97.
Title: Stat3-mediated activation of microRNA-23a suppresses gluconeogenesis in hepatocellular carcinoma by down-regulating glucose-6-phosphatase and peroxisome proliferator-activated receptor gamma, coactivator 1 alpha.
Author: Wang, Bo|Hsu, Shu-Hao|Frankel, Wendy|Ghoshal, Kalpana|Jacob, Samson T
PMID: 22318941
Journal: Cancer Prev Res (Phila). 2012 Apr;5(4):631-43.
Title: Celastrol suppresses growth and induces apoptosis of human hepatocellular carcinoma through the modulation of STAT3/JAK2 signaling cascade in vitro and in vivo.
Author: Rajendran, Peramaiyan|Li, Feng|Shanmugam, Muthu K|Kannaiyan, Radhamani|Goh, Jen Nee|Wong, Kwong Fai|Wang, Wei|Khin, Ester|Tergaonkar, Vinay|Kumar, Alan Prem|Luk, John M|Sethi, Gautam
PMID: 22369852
Journal: PLoS One. 2012;7(3):e33322.
Title: Heterodimerization of glycosylated insulin-like growth factor-1 receptors and insulin receptors in cancer cells sensitive to anti-IGF1R antibody.
Author: Kim, Jun Gyu|Kang, Min Jueng|Yoon, Young-Kwang|Kim, Hwang-Phill|Park, Jinah|Song, Sang-Hyun|Han, Sae-Won|Park, Jong-Wan|Kang, Gyeong Hoon|Kang, Keon Wook|Oh, Do Youn|Im, Seock-Ah|Bang, Yung-Jue|Yi, Eugene C|Kim, Tae-You
PMID: 22438913
Journal: Med Oncol. 2012 Dec;29(5):3046-54.
Title: Downregulation of GRIM-19 is associated with hyperactivation of p-STAT3 in hepatocellular carcinoma.
Author: Li, Feifei|Ren, Wanhua|Zhao, Yanda|Fu, Zhaoqing|Ji, Yongjian|Zhu, Yuhua|Qin, Chengyong
PMID: 22492280
Journal: J Biol Chem. 2012 Apr 20;287(17):13743-51.
Title: Constitutively active mutant gp130 receptor protein from inflammatory hepatocellular adenoma is inhibited by an anti-gp130 antibody that specifically neutralizes interleukin 11 signaling.
Author: Sommer, Jan|Effenberger, Timo|Volpi, Elena|Waetzig, Georg H|Bernhardt, Marten|Suthaus, Jan|Garbers, Christoph|Rose-John, Stefan|Floss, Doreen M|Scheller, Jurgen
PMID: 22523320
Journal: Transplant Proc. 2012 May;44(4):1099-103.
Title: Impact of coculture with ischemic preconditioned hepatocellular carcinoma cell line (Hep-G2) cells on insulin secreting function of rat insulin-secreting cell line (RIN-5F) cells.
Author: Joo, D J|Kim, J Y|Lee, J I|Kim, Y S|Fang, Y H|Jeong, J H|Kim, M S|Huh, K H
PMID: 22564635
Journal: Mol Cancer. 2012 May 8;11:31.
Title: Interferon-alpha enhances antitumor activities of oncolytic adenovirus-mediated IL-24 expression in hepatocellular carcinoma.
Author: Wang, Cong-Jun|Xiao, Chao-Wen|You, Tian-Geng|Zheng, Ya-Xin|Gao, Wei|Zhou, Zhu-Qing|Chen, Jun|Xue, Xin-Bo|Fan, Jia|Zhang, Hui
PMID: 22569271
Journal: Zhonghua Liu Xing Bing Xue Za Zhi. 2012 Feb;33(2):215-9.
Title: [Association of genetic polymorphisms of key molecules in JAK/STAT signaling pathway with susceptibility of hepatocellular carcinoma].
Author: Xie, Jia-xin|Yin, Jian-hua|Zhang, Qi|Pu, Rui|Zhang, Yu-wei|Lu, Wen-ying|Cao, Guang-wen
PMID: 22575147
Journal: Cancer Lett. 2012 Oct 28;323(2):215-22.
Title: Synergistic growth inhibition of human hepatocellular carcinoma cells by acyclic retinoid and GW4064, a farnesoid X receptor ligand.
Author: Ohno, Tomohiko|Shirakami, Yohei|Shimizu, Masahito|Kubota, Masaya|Sakai, Hiroyasu|Yasuda, Yoichi|Kochi, Takahiro|Tsurumi, Hisashi|Moriwaki, Hisataka
PMID: 22579649
Journal: Cell Physiol Biochem. 2012;29(5-6):863-74.
Title: Angiotensin II induces angiogenic factors production partly via AT1/JAK2/STAT3/SOCS3 signaling pathway in MHCC97H cells.
Author: Ji, Yuanyuan|Wang, Zhidong|Li, Zongfang|Li, Ke|Le, Xiaofeng|Zhang, Ting
PMID: 22613986
Journal: Hepatology. 2012 Dec;56(6):2375-86.
Title: The liver-specific tumor suppressor STAT5 controls expression of the reactive oxygen species-generating enzyme NOX4 and the proapoptotic proteins PUMA and BIM in mice.
Author: Yu, Ji Hoon|Zhu, Bing-Mei|Riedlinger, Gregory|Kang, Keunsoo|Hennighausen, Lothar
PMID: 22711600
Journal: Mol Nutr Food Res. 2012 Aug;56(8):1304-14.
Title: Molecular mechanism inhibiting human hepatocarcinoma cell invasion by 6-shogaol and 6-gingerol.
Author: Weng, Chia-Jui|Chou, Chai-Ping|Ho, Chi-Tang|Yen, Gow-Chin
PMID: 22714996
Journal: J Hepatol. 2012 Nov;57(5):1004-12.
Title: Deletion of IFNgamma enhances hepatocarcinogenesis in FXR knockout mice.
Author: Meng, Zhipeng|Wang, Xiaoqiong|Gan, Yichao|Zhang, Yunfeng|Zhou, Hong|Ness, Carl Van|Wu, Jun|Lou, Guiyu|Yu, Hua|He, Chao|Xu, Rongzhen|Huang, Wendong
PMID: 22728874
Journal: Semin Oncol. 2012 Aug;39(4):461-72.
Title: Clinical implications of cancer stem cell biology in hepatocellular carcinoma.
Author: Ji, Junfang|Wang, Xin Wei
PMID: 22846863
Journal: PLoS One. 2012;7(10):e47040.
Title: Comparison of the regulation of beta-catenin signaling by type I, type II and type III interferons in hepatocellular carcinoma cells.
Author: Li, Wei|Huang, Xiaojie|Tong, Hongfei|Wang, Yuxuan|Zhang, Tong|Wang, Wen|Dai, Lili|Li, Tongzeng|Lin, Shengzhang|Wu, Hao
PMID: 23056571
Journal: PLoS One. 2012;7(10):e46631.
Title: Iron regulator hepcidin exhibits antiviral activity against hepatitis C virus.
Author: Liu, Hongyan|Trinh, Thu Le|Dong, Huijia|Keith, Robertson|Nelson, David|Liu, Chen
PMID: 23110054
Journal: Mar Drugs. 2012 Sep;10(9):2055-68.
Title: In vivo induction of apoptosis by fucoxanthin, a marine carotenoid, associated with down-regulating STAT3/EGFR signaling in sarcoma 180 (S180) xenografts-bearing mice.
Author: Wang, Jun|Chen, Shihui|Xu, Shiqiang|Yu, Xing|Ma, Dongqing|Hu, Xiamin|Cao, Xiaolu
PMID: 23118721
Journal: Cancer Biomark. 2012;11(4):161-71.
Title: Interleukin-6 and oncostatin M are elevated in liver disease in conjunction with candidate hepatocellular carcinoma biomarker GP73.
Author: Liang, Hongyan|Block, Timothy M|Wang, Mengjun|Nefsky, Bradley|Long, Ronald|Hafner, Julie|Mehta, Anand S|Marrero, Jorge|Gish, Robert|Norton, Pamela A
PMID: 23144154
Journal: Oncol Lett. 2012 Nov;4(5):1092-1096.
Title: High levels of beta-catenin promote IFNgamma-induced apoptosis in hepatocellular carcinoma cells.
Author: Li, Wei|Tong, Hongfei|Huang, Xiaojie|Wang, Wen|Wu, Hao|Lin, Shengzhang
PMID: 23162658
Journal: J Transl Med. 2012 Nov 21;10:230.
Title: After insufficient radiofrequency ablation, tumor-associated endothelial cells exhibit enhanced angiogenesis and promote invasiveness of residual hepatocellular carcinoma.
Author: Kong, Jian|Kong, Lingqun|Kong, Jinge|Ke, Shan|Gao, Jun|Ding, Xuemei|Zheng, Lemin|Sun, Huichuan|Sun, Wenbing
PMID: 23171368
Journal: Mol Carcinog. 2013 Oct;52(10):800-12.
Title: Suppression of AMF/PGI-mediated tumorigenic activities by ursolic acid in cultured hepatoma cells and in a mouse model.
Author: Shih, Wen-Ling|Yu, Feng-Ling|Chang, Ching-Dong|Liao, Ming-Huei|Wu, Hung-Yi|Lin, Ping-Yuan
PMID: 22549898
Journal: Ann Surg Oncol. 2013 Jan;20(1):267-76.
Title: Interferon regulatory factor (IRF)-1 and IRF-2 are associated with prognosis and tumor invasion in HCC.
Author: Yi, Yong|Wu, Han|Gao, Qiang|He, Hong-Wei|Li, Yi-Wei|Cai, Xiao-Yan|Wang, Jia-Xing|Zhou, Jian|Cheng, Yun-Feng|Jin, Jian-Jun|Fan, Jia|Qiu, Shuang-Jian
PMID: 22805863
Journal: Hepatology. 2013 Feb;57(2):678-88.
Title: Estrogen-sensitive PTPRO expression represses hepatocellular carcinoma progression by control of STAT3.
Author: Hou, Jiajie|Xu, Juan|Jiang, Runqiu|Wang, Youjing|Chen, Chen|Deng, Lei|Huang, Xingxu|Wang, Xuehao|Sun, Beicheng
PMID: 22821478
Journal: Cancer Lett. 2013 Jan 28;328(2):243-51.
Title: Evodiamine inhibits STAT3 signaling by inducing phosphatase shatterproof 1 in hepatocellular carcinoma cells.
Author: Yang, Jie|Cai, Xueting|Lu, Wuguang|Hu, Chunping|Xu, Xiaojun|Yu, Qiang|Cao, Peng
PMID: 23032719
Journal: J Hepatol. 2013 Feb;58(2):350-7.
Title: Molecular characterization of hepatocellular adenomas developed in patients with glycogen storage disease type I.
Author: Calderaro, Julien|Labrune, Philippe|Morcrette, Guillaume|Rebouissou, Sandra|Franco, Dominique|Prevot, Sophie|Quaglia, Alberto|Bedossa, Pierre|Libbrecht, Louis|Terracciano, Luigi|Smit, G Peter A|Bioulac-Sage, Paulette|Zucman-Rossi, Jessica
PMID: 23046672
Journal: Curr Pharm Des. 2013;19(7):1192-200.
Title: Epigenetic deregulation of microRNAs: new opportunities to target oncogenic signaling pathways in hepatocellular carcinoma.
Author: Yu, Zhuo|Cheng, Alfred Sze-Lok
PMID: 23092339
Journal: Biochim Biophys Acta. 2013 Jan;1835(1):46-60.
Title: Potential role of signal transducer and activator of transcription (STAT)3 signaling pathway in inflammation, survival, proliferation and invasion of hepatocellular carcinoma.
Author: Subramaniam, Aruljothi|Shanmugam, Muthu K|Perumal, Ekambaram|Li, Feng|Nachiyappan, Alamelu|Dai, Xiaoyun|Swamy, Shivananju Nanjunda|Ahn, Kwang Seok|Kumar, Alan Prem|Tan, Benny K H|Hui, Kam Man|Sethi, Gautam
PMID: 23103770
Journal: J Cell Biochem. 2013 May;114(5):1097-104.
Title: HBx-dependent activation of Twist mediates STAT3 control of epithelium-mesenchymal transition of liver cells.
Author: Teng, Jing|Wang, Xiaoqian|Xu, Zhenxing|Tang, Nanhong
PMID: 23161342
Journal: Phytother Res. 2013 Oct;27(10):1524-8.
Title: Scutellarin-induced apoptosis in HepG2 hepatocellular carcinoma cells via a STAT3 pathway.
Author: Xu, Haitao|Zhang, Songyan
PMID: 23192830
Journal: Int J Oncol. 2013 Feb;42(2):574-82.
Title: ANT2 suppression by shRNA may be able to exert anticancer effects in HCC further by restoring SOCS1 expression.
Author: Jang, Ji-Young|Jeon, Yoon-Kyung|Lee, Choong-Eun|Kim, Chul-Woo
PMID: 23242177
Journal: Gastroenterology. 2013 Apr;144(4):829-40.
Title: Integrative molecular analysis of intrahepatic cholangiocarcinoma reveals 2 classes that have different outcomes.
Author: Sia, Daniela|Hoshida, Yujin|Villanueva, Augusto|Roayaie, Sasan|Ferrer, Joana|Tabak, Barbara|Peix, Judit|Sole, Manel|Tovar, Victoria|Alsinet, Clara|Cornella, Helena|Klotzle, Brandy|Fan, Jian-Bing|Cotsoglou, Christian|Thung, Swan N|Fuster, Josep|Waxman, Sam
PMID: 23295441
Journal: Cell Death Dis. 2013 Feb 7;4:e485.
Title: Mcl-1-dependent activation of Beclin 1 mediates autophagic cell death induced by sorafenib and SC-59 in hepatocellular carcinoma cells.
Author: Tai, W-T|Shiau, C-W|Chen, H-L|Liu, C-Y|Lin, C-S|Cheng, A-L|Chen, P-J|Chen, K-F
PMID: 23392173
Journal: Int J Hepatol. 2013;2013:315947.
Title: Molecular classification of hepatocellular adenomas.
Author: Nault, Jean Charles|Zucman Rossi, Jessica
PMID: 23401783
Journal: Oncol Lett. 2013 Mar;5(3):1053-1057.
Title: GSTP1 negatively regulates Stat3 activation in epidermal growth factor signaling.
Author: Kou, Xianjuan|Chen, Ning|Feng, Zhiyong|Luo, Lan|Yin, Zhimin
PMID: 23426146
Journal: PLoS One. 2013;8(2):e56542.
Title: Negative correlation of LIV-1 and E-cadherin expression in hepatocellular carcinoma cells.
Author: Shen, Rongxi|Xie, Feng|Shen, Hui|liu, Qu|Zheng, Tao|Kou, Xingrui|Wang, Dexian|Yang, Jiamei
PMID: 23437163
Journal: Int J Radiat Oncol Biol Phys. 2013 Jul 1;86(3):456-62.
Title: Sorafenib enhances radiation-induced apoptosis in hepatocellular carcinoma by inhibiting STAT3.
Author: Huang, Chao-Yuan|Lin, Chen-Si|Tai, Wei-Tien|Hsieh, Chi-Ying|Shiau, Chung-Wai|Cheng, Ann-Lii|Chen, Kuen-Feng
PMID: 23474115
Journal: Protein Cell. 2013 Mar;4(3):176-85.
Title: NF-kappaB and STAT3 signaling pathways collaboratively link inflammation to cancer.
Author: Fan, Yihui|Mao, Renfang|Yang, Jianhua
PMID: 23483479
Journal: Hepatology. 2013 Aug;58(2):680-91.
Title: Signal regulatory protein alpha is associated with tumor-polarized macrophages phenotype switch and plays a pivotal role in tumor progression.
Author: Pan, Yu-fei|Tan, Ye-xiong|Wang, Min|Zhang, Jian|Zhang, Bo|Yang, Chun|Ding, Zhi-wen|Dong, Li-wei|Wang, Hong-yang
PMID: 23504854
Journal: PLoS One. 2013;8(3):e59591.
Title: HCMV activates the IL-6-JAK-STAT3 axis in HepG2 cells and primary human hepatocytes.
Author: Lepiller, Quentin|Abbas, Wasim|Kumar, Amit|Tripathy, Manoj K|Herbein, Georges
PMID: 23555719
Journal: PLoS One. 2013 Apr 19;8(4):e61678.
Title: Acetylcholine acts on androgen receptor to promote the migration and invasion but inhibit the apoptosis of human hepatocarcinoma.
Author: Nie, Huizhen|Cao, Qingzhen|Zhu, Lei|Gong, Yuehua|Gu, Jianren|He, Zuping
PMID: 23620780
Journal: Cancer Gene Ther. 2013 Jun;20(6):366-74.
Title: Aspirin enhances IFN-alpha-induced growth inhibition and apoptosis of hepatocellular carcinoma via JAK1/STAT1 pathway.
Author: Li, T|Dong, Z-R|Guo, Z-Y|Wang, C-H|Tang, Z-Y|Qu, S-F|Chen, Z-T|Li, X-W|Zhi, X-T
PMID: 23703473
Journal: BMC Cancer. 2013 May 30;13:267.
Title: Molecular mechanisms of action and potential biomarkers of growth inhibition of dasatinib (BMS-354825) on hepatocellular carcinoma cells.
Author: Chang, Alex Y|Wang, Miao
PMID: 23721490
Journal: Br J Cancer. 2013 Jul 9;109(1):83-91.
Title: Inhibition of VEGF expression through blockade of Hif1alpha and STAT3 signalling mediates the anti-angiogenic effect of melatonin in HepG2 liver cancer cells.
Author: Carbajo-Pescador, S|Ordonez, R|Benet, M|Jover, R|Garcia-Palomo, A|Mauriz, J L|Gonzalez-Gallego, J
PMID: 23756865
Journal: J Huazhong Univ Sci Technolog Med Sci. 2013 Jun;33(3):339-345.
Title: Germacrone induces apoptosis in human hepatoma HepG2 cells through inhibition of the JAK2/STAT3 signalling pathway.
Author: Liu, Yun-Yi|Zheng, Qian|Fang, Bin|Wang, Wei|Ma, Feng-Yun|Roshan, Sadia|Banafa, Amal|Chen, Ming-Jie|Chang, Jun-Li|Deng, Xiao-Min|Li, Ke-Xiu|Yang, Guang-Xiao|He, Guang-Yuan
PMID: 23771657
Journal: Toxicol Appl Pharmacol. 2013 Oct 15;272(2):299-305.
Title: Small heterodimer partner overexpression partially protects against liver tumor development in farnesoid X receptor knockout mice.
Author: Li, Guodong|Kong, Bo|Zhu, Yan|Zhan, Le|Williams, Jessica A|Tawfik, Ossama|Kassel, Karen M|Luyendyk, James P|Wang, Li|Guo, Grace L
PMID: 23811326
Journal: Br J Pharmacol. 2013 Oct;170(4):807-21.
Title: Emodin inhibits growth and induces apoptosis in an orthotopic hepatocellular carcinoma model by blocking activation of STAT3.
Author: Subramaniam, Aruljothi|Shanmugam, Muthu K|Ong, Tina H|Li, Feng|Perumal, Ekambaram|Chen, Luxi|Vali, Shireen|Abbasi, Taher|Kapoor, Shweta|Ahn, Kwang Seok|Kumar, Alan Prem|Hui, Kam M|Sethi, Gautam
PMID: 23848338
Journal: J Gastroenterol Hepatol. 2013 Aug;28 Suppl 1:77-84.
Title: Alcoholic liver disease: pathogenesis, management, and novel targets for therapy.
Author: Orman, Eric S|Odena, Gemma|Bataller, Ramon
PMID: 23855300
Journal: BMC Cancer. 2013 Jul 29;13:363.
Title: Schedule-dependent antitumor effects of 5-fluorouracil combined with sorafenib in hepatocellular carcinoma.
Author: Deng, Lifen|Ren, Zhenggang|Jia, Qingan|Wu, Weizhong|Shen, Hujia|Wang, Yanhong
PMID: 23895220
Journal: Cancer Lett. 2013 Dec 1;341(2):139-49.
Title: Targeted abrogation of diverse signal transduction cascades by emodin for the treatment of inflammatory disorders and cancer.
Author: Shrimali, Deepti|Shanmugam, Muthu K|Kumar, Alan Prem|Zhang, Jingwen|Tan, Benny K H|Ahn, Kwang Seok|Sethi, Gautam
PMID: 23962559
Journal: Oncol Rep. 2013 Dec;30(6):2820-8.
Title: Resveratrol suppresses the STAT3 signaling pathway and inhibits proliferation of high glucose-exposed HepG2 cells partly through SIRT1.
Author: Li, Yongguang|Zhu, Wei|Li, Jingbo|Liu, Mingya|Wei, Meng
PMID: 24064760
Journal: Cancer Prev Res (Phila). 2013 Dec;6(12):1304-16.
Title: Lycopene metabolite, apo-10'-lycopenoic acid, inhibits diethylnitrosamine-initiated, high fat diet-promoted hepatic inflammation and tumorigenesis in mice.
Author: Ip, Blanche C|Hu, Kang-Quan|Liu, Chun|Smith, Donald E|Obin, Martin S|Ausman, Lynne M|Wang, Xiang-Dong
PMID: 24085778
Journal: Mol Cancer. 2013 Oct 5;12(1):114.
Title: LBH589 Inhibits proliferation and metastasis of hepatocellular carcinoma via inhibition of gankyrin/STAT3/Akt pathway.
Author: Song, Xuan|Wang, Jiabei|Zheng, Tongsen|Song, Ruipeng|Liang, Yingjian|Bhatta, Nishant|Yin, Dalong|Pan, Shangha|Liu, Jiaren|Jiang, Hongchi|Liu, Lianxin
PMID: 24093956
Journal: Mol Cancer Ther. 2013 Dec;12(12):2885-96.
Title: Targeting blockage of STAT3 in hepatocellular carcinoma cells augments NK cell functions via reverse hepatocellular carcinoma-induced immune suppression.
Author: Sun, Xiaoxia|Sui, Qiangjun|Zhang, Cai|Tian, Zhigang|Zhang, Jian
PMID: 24107450
Journal: Front Genet. 2013 Oct 31;4:224.
Title: Altered methylation and expression of ER-associated degradation factors in long-term alcohol and constitutive ER stress-induced murine hepatic tumors.
Author: Han, Hui|Hu, Jay|Lau, Mo Y|Feng, Min|Petrovic, Lydia M|Ji, Cheng
PMID: 24198826
Journal: Zhonghua Gan Zang Bing Za Zhi. 2013 Nov;21(11):845-9.
Title: [Anti-proliferation effect of sorafenib in combination with 5-FU for hepatocellular carcinoma in vitro: antagonistic performance and mechanism].
Author: Deng, Li-fen|Wang, Yan-hong|Jia, Qing-an|Ren, Zheng-gang|Shen, Hu-jia|Sun, Xiao-jing|Li, Jing-huan
PMID: 24331695
Journal: PLoS One. 2013 Dec 20;8(12):e83332.
Title: EGFRvIII mediates hepatocellular carcinoma cell invasion by promoting S100 calcium binding protein A11 expression.
Author: Luo, Xiaoying|Xie, Hailong|Long, Xiaolan|Zhou, Min|Xu, Zhibin|Shi, Bizhi|Jiang, Hua|Li, Zonghai
PMID: 24376686
Journal: Liver Cancer. 2013 Aug;2(3-4):367-83.
Title: From cirrhosis to hepatocellular carcinoma: new molecular insights on inflammation and cellular senescence.
Author: Ramakrishna, Gayatri|Rastogi, Archana|Trehanpati, Nirupama|Sen, Bijoya|Khosla, Ritu|Sarin, Shiv K
PMID: 24400224
Journal: Mol Carcinog. 2014 Jan;53(1):67-76.
Title: Serine 727 phosphorylation of STAT3: an early change in mouse hepatocarcinogenesis induced by neonatal treatment with diethylnitrosamine.
Author: Miyakoshi, Masaaki|Yamamoto, Masahiro|Tanaka, Hiroki|Ogawa, Katsuhiro
PMID: 22911886
Journal: Hepatology. 2014 Jan;59(1):216-27.
Title: Novel RNA oligonucleotide improves liver function and inhibits liver carcinogenesis in vivo.
Author: Reebye, Vikash|Saetrom, Pal|Mintz, Paul J|Huang, Kai-Wen|Swiderski, Piotr|Peng, Ling|Liu, Cheng|Liu, Xiaoxuan|Lindkaer-Jensen, Steen|Zacharoulis, Dimitris|Kostomitsopoulos, Nikolaos|Kasahara, Noriyuki|Nicholls, Joanna P|Jiao, Long R|Pai, Madhava|Spalding,
PMID: 23929703
Journal: Gastroenterology. 2014 Jan;146(1):222-32.e35.
Title: Leptin receptor somatic mutations are frequent in HCV-infected cirrhotic liver and associated with hepatocellular carcinoma.
Author: Ikeda, Atsuyuki|Shimizu, Takahiro|Matsumoto, Yuko|Fujii, Yosuke|Eso, Yuji|Inuzuka, Tadashi|Mizuguchi, Aya|Shimizu, Kazuharu|Hatano, Etsuro|Uemoto, Shinji|Chiba, Tsutomu|Marusawa, Hiroyuki
PMID: 24055508
Journal: J Gastroenterol. 2014 Sep;49(9):1342-51.
Title: Increased adiponectin associated with poor survival in hepatocellular carcinoma.
Author: Wang, Shen-Nien|Yang, Sheau-Fang|Tsai, Hsin-Hui|Lee, King-Teh|Yeh, Yao-Tsung
PMID: 24132578
Journal: Carcinogenesis. 2014 Mar;35(3):537-45.
Title: Twist2 promotes self-renewal of liver cancer stem-like cells by regulating CD24.
Author: Liu, Allan Yi|Cai, Yao|Mao, Yubin|Lin, Yancheng|Zheng, Hong|Wu, Tiantian|Huang, Yangmei|Fang, Xiaoguang|Lin, Shuyong|Feng, Qingzhao|Huang, Zhengjie|Yang, Tianci|Luo, Qi|Ouyang, Gaoliang
PMID: 24193512
Journal: Mol Cancer Ther. 2014 Jan;13(1):27-36.
Title: SC-60, a dimer-based sorafenib derivative, shows a better anti-hepatocellular carcinoma effect than sorafenib in a preclinical hepatocellular carcinoma model.
Author: Tai, Wei-Tien|Shiau, Chung-Wai|Li, Yong-Shi|Chen, Yao-Li|Chu, Pei-Yi|Huang, Jui-Wen|Hsu, Cheng-Yi|Hsu, Yi-Chieh|Chen, Pei-Jer|Chen, Kuen-Feng
PMID: 24275147
Journal: Nephrol Dial Transplant. 2014 Jun;29(6):1141-4.
Title: Low hepcidin triggers hepatic iron accumulation in patients with hepatitis C.
Author: Horl, Walter H|Schmidt, Alice
PMID: 24286977
Journal: Cancer Biol Ther. 2014 Jan;15(1):1-2.
Title: Multi-kinase inhibition in ovarian cancer.
Author: Dent, Paul
PMID: 24309512
Journal: Food Chem Toxicol. 2014 Feb;64:217-24.
Title: Cucurbitacin B and cucurbitacin I suppress adipocyte differentiation through inhibition of STAT3 signaling.
Author: Seo, Cho-Rong|Yang, Dong Kwon|Song, No-Joon|Yun, Ui Jeong|Gwon, A-Ryeong|Jo, Dong-Gyu|Cho, Jae Youl|Yoon, Keejung|Ahn, Jee-Yin|Nho, Chu Won|Park, Woo Jin|Yang, Seung Yul|Park, Kye Won
PMID: 24316209
Journal: Oncol Lett. 2014 Jan;7(1):101-106.
Title: Knockdown of astrocyte elevated gene-1 inhibits growth through suppression of IL-6 secretion in HepG2 human hepatoma cells.
Author: Deng, Huan|Zhou, Zhenzhen|Tu, Wei|Xia, Yujia|Huang, Huanjun|Tian, De'an
PMID: 24348829
Journal: FEBS Lett. 2014 Feb 14;588(4):566-73.
Title: Hepatitis C virus core protein regulates NANOG expression via the stat3 pathway.
Author: Zhou, Jia-Jia|Chen, Ru-Fu|Deng, Xiao-Geng|Zhou, Yu|Ye, Xiao|Yu, Min|Tang, Jing|He, Xiao-Yu|Cheng, Di|Zeng, Bing|Zhou, Quan-bo|Li, Zhi-hua
PMID: 24462277
Journal: J Invest Surg. 2014 Aug;27(4):197-204.
Title: Loss of suppressors of cytokine signaling 3 promotes aggressiveness in hepatocellular carcinoma.
Author: Wu, Wen-Yong|Kim, Hyunchul|Zhang, Chang-Le|Meng, Xiang-Ling|Wu, Zheng-Sheng
PMID: 24476004
Journal: Clin Cancer Res. 2014 Mar 1;20(5):1274-1287.
Title: Synergistic interaction between the HDAC inhibitor, MPT0E028, and sorafenib in liver cancer cells in vitro and in vivo.
Author: Chen, Chun-Han|Chen, Mei-Chuan|Wang, Jing-Chi|Tsai, An-Chi|Chen, Ching-Shih|Liou, Jing-Ping|Pan, Shiow-Lin|Teng, Che-Ming
PMID: 24520095
Journal: Int J Clin Exp Med. 2014 Feb 15;7(2):348-55. eCollection 2014.
Title: Serine threonine kinase Pim-3 regulates STAT3 pathway to inhibit proliferation of human liver cancers.
Author: Wang, Jianqiang|Lao, Lijun|Zhao, Hui|Huang, Yuan
PMID: 24600488
Journal: Cell Signal. 2014 Jun;26(6):1347-54.
Title: MicroRNA-363-mediated downregulation of S1PR1 suppresses the proliferation of hepatocellular carcinoma cells.
Author: Zhou, Peng|Huang, Gang|Zhao, Yuanyin|Zhong, Dan|Xu, Zhizhen|Zeng, Yijun|Zhang, Yan|Li, Song|He, Fengtian
PMID: 24631531
Journal: J Hepatol. 2014 Jul;61(1):89-97.
Title: Nintedanib (BIBF-1120) inhibits hepatocellular carcinoma growth independent of angiokinase activity.
Author: Tai, Wei-Tien|Shiau, Chung-Wai|Li, Yong-Shi|Chang, Chun-Wei|Huang, Jui-Wen|Hsueh, Ting-Ting|Yu, Hui-Chuan|Chen, Kuen-Feng
PMID: 24657398
Journal: J Transl Med. 2014 Apr 8;12:93.
Title: Role of estrogen in hepatocellular carcinoma: is inflammation the key?
Author: Shi, Liang|Feng, Yili|Lin, Hui|Ma, Rui|Cai, Xiujun
PMID: 24708807
Journal: Int J Biol Sci. 2014 Mar 21;10(4):415-25.
Title: Cantharidin exerts anti-hepatocellular carcinoma by miR-214 modulating macrophage polarization.
Author: Lu, Sen|Gao, Yun|Huang, Xinli|Wang, Xuehao
PMID: 24719559
Journal: Cancer Res. 2014 Jun 15;74(12):3306-16.
Title: Separating Tumorigenicity from Bile Acid Regulatory Activity for Endocrine Hormone FGF19.
Author: Zhou, Mei|Wang, Xueyan|Phung, Van|Lindhout, Darrin A|Mondal, Kalyani|Hsu, Jer-Yuan|Yang, Hong|Humphrey, Mark|Ding, Xunshan|Arora, Taruna|Learned, R Marc|DePaoli, Alex M|Tian, Hui|Ling, Lei
PMID: 24728076
Journal: Cancer Lett. 2014 Jul 28;349(2):136-43.
Title: A sorafenib derivative and novel SHP-1 agonist, SC-59, acts synergistically with radiotherapy in hepatocellular carcinoma cells through inhibition of STAT3.
Author: Huang, Chao-Yuan|Tai, Wei-Tien|Hsieh, Chi-Ying|Hsu, Wan-Mai|Lai, Ying-Jiun|Chen, Li-Ju|Shiau, Chung-Wai|Chen, Kuen-Feng
PMID: 24735751
Journal: Cancer Cell. 2014 Apr 14;25(4):428-41.
Title: Genomic profiling of hepatocellular adenomas reveals recurrent FRK-activating mutations and the mechanisms of malignant transformation.
Author: Pilati, Camilla|Letouze, Eric|Nault, Jean-Charles|Imbeaud, Sandrine|Boulai, Anais|Calderaro, Julien|Poussin, Karine|Franconi, Andrea|Couchy, Gabrielle|Morcrette, Guillaume|Mallet, Maxime|Taouji, Said|Balabaud, Charles|Terris, Benoit|Canal, Frederic|Paradi
PMID: 24735922
Journal: J Physiol Pharmacol. 2014 Apr;65(2):209-15.
Title: Aging impairs transcriptional regulation of vascular endothelial growth factor in human microvascular endothelial cells: implications for angiogenesis and cell survival.
Author: Ahluwalia, A|Jones, M K|Szabo, S|Tarnawski, A S
PMID: 24781730
Journal: Int J Cancer. 2014 Dec 15;135(12):2972-83.
Title: A preclinical evaluation of a novel multikinase inhibitor, SKLB-329, as a therapeutic agent against hepatocellular carcinoma.
Author: Zhong, Lei|Fu, Xiao-Yu|Zou, Chan|Yang, Ling-Ling|Zhou, Shu|Yang, Jiao|Tang, Yun|Cheng, Chuan|Li, Lin-Li|Xiang, Rong|Chen, Li-Juan|Chen, Yu-Zong|Wei, Yu-Quan|Yang, Sheng-Yong
PMID: 24789676
Journal: J Virol. 2014 Jul;88(14):7929-40.
Title: Transcriptional suppression of miR-181c by hepatitis C virus enhances homeobox A1 expression.
Author: Mukherjee, Anupam|Shrivastava, Shubham|Bhanja Chowdhury, Joydip|Ray, Ranjit|Ray, Ratna B
PMID: 24789793
Journal: Toxicology. 2014 Aug 1;322:99-108.
Title: The evaluation of p,p'-DDT exposure on cell adhesion of hepatocellular carcinoma.
Author: Jin, Xiaoting|Chen, Meilan|Song, Li|Li, Hanqing|Li, Zhuoyu
PMID: 24820114
Journal: Oncotarget. 2014 Jul 15;5(13):4909-19.
Title: RFX1-dependent activation of SHP-1 induces autophagy by a novel obatoclax derivative in hepatocellular carcinoma cells.
Author: Su, Jung-Chen|Tseng, Ping-Hui|Hsu, Cheng-Yi|Tai, Wei-Tien|Huang, Jui-Wen|Ko, Ching-Huai|Lin, Mai-Wei|Liu, Chun-Yu|Chen, Kuen-Feng|Shiau, Chung-Wai
PMID: 24952874
Journal: J Exp Clin Cancer Res. 2014 Jun 30;33:55.
Title: A novel miR-219-SMC4-JAK2/Stat3 regulatory pathway in human hepatocellular carcinoma.
Author: Zhou, Bo|Chen, Hongxu|Wei, Dong|Kuang, Yi|Zhao, Xiaobiao|Li, Guangyao|Xie, Jun|Chen, Ping
PMID: 24980149
Journal: J Immunol. 2014 Aug 15;193(4):2016-23.
Title: NK cells are the crucial antitumor mediators when STAT3-mediated immunosuppression is blocked in hepatocellular carcinoma.
Author: Sui, Qiangjun|Zhang, Jian|Sun, Xiaoxia|Zhang, Cai|Han, Qiuju|Tian, Zhigang
PMID: 25015826
Journal: Neoplasia. 2014 Jul;16(7):595-605.
Title: SC-2001 overcomes STAT3-mediated sorafenib resistance through RFX-1/SHP-1 activation in hepatocellular carcinoma.
Author: Su, Jung-Chen|Tseng, Ping-Hui|Wu, Szu-Hsien|Hsu, Cheng-Yi|Tai, Wei-Tien|Li, Yong-Shi|Chen, I-Ting|Liu, Chun-Yu|Chen, Kuen-Feng|Shiau, Chung-Wai
PMID: 25047655
Journal: Asian Pac J Trop Med. 2014 May;7(5):368-72.
Title: Effects of mTOR-STAT3 on the migration and invasion abilities of hepatoma cell and mTOR-STAT3 expression in liver cancer.
Author: Pu, Xia|Guo, Qing-Xi|Long, Han-An|Yang, Cheng-Wan
PMID: 25063062
Journal: J Leukoc Biol. 2014 Nov;96(5):883-94.
Title: Liver metastases induce reversible hepatic B cell dysfunction mediated by Gr-1+CD11b+ myeloid cells.
Author: Thorn, Mitchell|Point, Gary R|Burga, Rachel A|Nguyen, Cang T|Joseph Espat, N|Katz, Steven C
PMID: 25085111
Journal: Eur J Cancer. 2014 Oct;50(15):2560-9.
Title: Hepatitis B virus X protein promotes hepatocellular carcinoma transformation through interleukin-6 activation of microRNA-21 expression.
Author: Li, Chi Han|Xu, Feiyue|Chow, Sheungching|Feng, Lu|Yin, Deling|Ng, Tzi Bun|Chen, Yangchao
PMID: 25087183
Journal: Br J Cancer. 2014 Sep 23;111(7):1327-37.
Title: Negative regulation of signal transducer and activator of transcription-3 signalling cascade by lupeol inhibits growth and induces apoptosis in hepatocellular carcinoma cells.
Author: Siveen, K S|Nguyen, A H|Lee, J H|Li, F|Singh, S S|Kumar, A P|Low, G|Jha, S|Tergaonkar, V|Ahn, K S|Sethi, G
PMID: 25101566
Journal: Gastroenterology. 2014 Dec;147(6):1393-404.
Title: Tumor-associated macrophages produce interleukin 6 and signal via STAT3 to promote expansion of human hepatocellular carcinoma stem cells.
Author: Wan, Shanshan|Zhao, Ende|Kryczek, Ilona|Vatan, Linda|Sadovskaya, Anna|Ludema, Gregory|Simeone, Diane M|Zou, Weiping|Welling, Theodore H
PMID: 25181692
Journal: Cancer Res. 2014 Nov 1;74(21):6184-93.
Title: Genetic deletion of AEG-1 prevents hepatocarcinogenesis.
Author: Robertson, Chadia L|Srivastava, Jyoti|Siddiq, Ayesha|Gredler, Rachel|Emdad, Luni|Rajasekaran, Devaraja|Akiel, Maaged|Shen, Xue-Ning|Guo, Chunqing|Giashuddin, Shah|Wang, Xiang-Yang|Ghosh, Shobha|Subler, Mark A|Windle, Jolene J|Fisher, Paul B|Sarkar, Devana
PMID: 25193383
Journal: Lab Invest. 2014 Nov;94(11):1273-82.
Title: Western diet in ApoE-LDLR double-deficient mouse model of atherosclerosis leads to hepatic steatosis, fibrosis, and tumorigenesis.
Author: Kampschulte, Marian|Stockl, Christiane|Langheinrich, Alexander C|Althohn, Ulrike|Bohle, Rainer M|Krombach, Gabriele A|Stieger, Philipp|Churin, Yuri|Kremer, Sandra|Dierkes, Christian|Rath, Timo|Roeb, Elke|Roderfeld, Martin
PMID: 25199052
Journal: Zhongguo Zhong Xi Yi Jie He Za Zhi. 2014 Aug;34(8):976-81.
Title: [Effect of bear bile powder on STAT3 pathway in hepatocellular carcinoma xenograft].
Author: Zhao, Jin-Yan|Liu, Li-Ya|Shen, A-Ling|Lin, Wei|Cao, Zhi-Yun|Zhuang, Qun-Chuan|Hong, Zhen-Feng
PMID: 25223184
Journal: Clin Cancer Res. 2014 Nov 15;20(22):5768-76.
Title: STAT3 mediates regorafenib-induced apoptosis in hepatocellular carcinoma.
Author: Tai, Wei-Tien|Chu, Pei-Yi|Shiau, Chung-Wai|Chen, Yao-Li|Li, Yong-Shi|Hung, Man-Hsin|Chen, Li-Ju|Chen, Pei-Lung|Su, Jung-Chen|Lin, Ping-Yi|Yu, Hui-Chuan|Chen, Kuen-Feng
PMID: 25248379
Journal: Oncotarget. 2014 Sep 30;5(18):8478-91.
Title: The iron chelator Dp44mT inhibits hepatocellular carcinoma metastasis via N-Myc downstream-regulated gene 2 (NDRG2)/gp130/STAT3 pathway.
Author: Wang, Jiabei|Yin, Dalong|Xie, Changming|Zheng, Tongsen|Liang, Yingjian|Hong, Xuehui|Lu, Zhaoyang|Song, Xuan|Song, Ruipeng|Yang, Haiyan|Sun, Boshi|Bhatta, Nishant|Meng, Xianzhi|Pan, Shangha|Jiang, Hongchi|Liu, Lianxin
PMID: 25261367
Journal: Cancer Res. 2014 Nov 15;74(22):6623-34.
Title: MPHOSPH1: a potential therapeutic target for hepatocellular carcinoma.
Author: Liu, Xinran|Zhou, Yafan|Liu, Xinyuan|Peng, Anlin|Gong, Hao|Huang, Lizi|Ji, Kaige|Petersen, Robert B|Zheng, Ling|Huang, Kun
PMID: 25269478
Journal: Cancer Prev Res (Phila). 2014 Dec;7(12):1219-27.
Title: Lycopene attenuated hepatic tumorigenesis via differential mechanisms depending on carotenoid cleavage enzyme in mice.
Author: Ip, Blanche C|Liu, Chun|Ausman, Lynne M|von Lintig, Johannes|Wang, Xiang-Dong
PMID: 25293877
Journal: ACS Appl Mater Interfaces. 2014 Dec 24;6(24):22423-9.
Title: Paper-based microreactor integrating cell culture and subsequent immunoassay for the investigation of cellular phosphorylation.
Author: Lei, Kin Fong|Huang, Chia-Hao
PMID: 25421089
Journal: PLoS Med. 2014 Dec 23;11(12):e1001770.
Title: Genomic predictors for recurrence patterns of hepatocellular carcinoma: model derivation and validation.
Author: Kim, Ji Hoon|Sohn, Bo Hwa|Lee, Hyun-Sung|Kim, Sang-Bae|Yoo, Jeong Eun|Park, Yun-Yong|Jeong, Woojin|Lee, Sung Sook|Park, Eun Sung|Kaseb, Ahmed|Kim, Baek Hui|Kim, Wan Bae|Yeon, Jong Eun|Byun, Kwan Soo|Chu, In-Sun|Kim, Sung Soo|Wang, Xin Wei|Thorgeirsson, Sn
PMID: 25536056
Journal: Hepatol Int. 2014 Jan;8(1):55-63.
Title: The co-inhibitory pathway and cellular immune imbalance in the progress of HBV infection.
Author: Chen, Jie|Wang, Lanlan|Fu, Yang|Li, Yi|Bai, Yangjuan|Luo, Limei|Liao, Yun
PMID: 26202406
Journal: Hepatol Int. 2014 Jul;8(3):330-8.
Title: Oncogenic signaling pathways and origins of tumor-initiating stem-like cells of hepatocellular carcinomas induced by hepatitis C virus, alcohol and/or obesity.
Author: Chen, Chia-Lin|Tsukamoto, Hidekazu|Machida, Keigo
PMID: 26202636
Journal: Hepat Oncol. 2014 Jan;1(1):107-120.
Title: STAT3 in hepatocellular carcinoma: new perspectives.
Author: Svinka, Jasmin|Mikulits, Wolfgang|Eferl, Robert
PMID: 30190945
Journal: Histopathology. 2015 May;66(6):836-45.
Title: Clinicopathological characteristics of serum amyloid A-positive hepatocellular neoplasms/nodules arising in alcoholic cirrhosis.
Author: Sasaki, Motoko|Yoneda, Norihide|Sawai, Yoshiyuki|Imai, Yasuharu|Kondo, Fukuo|Fukusato, Toshio|Yoshikawa, Seiichi|Kobayashi, Satoshi|Sato, Yasunori|Matsui, Osamu|Nakanuma, Yasuni
PMID: 25318388
Journal: Int J Cancer. 2015 Jun 1;136(11):2556-65.
Title: Metformin decreases IL-22 secretion to suppress tumor growth in an orthotopic mouse model of hepatocellular carcinoma.
Author: Zhao, Dong|Long, Xi-Dai|Lu, Tian-Fei|Wang, Tao|Zhang, Wei-Wei|Liu, Yi-Xiao|Cui, Xiao-Lan|Dai, Hui-Juan|Xue, Feng|Xia, Qiang
PMID: 25370454
Journal: Oncol Rep. 2015 Jan;33(1):274-82.
Title: Hepatocellular carcinomas promote tumor-associated macrophage M2-polarization via increased B7-H3 expression.
Author: Kang, Fu-Biao|Wang, Ling|Li, Dong|Zhang, Yin-Ge|Sun, Dian-Xing
PMID: 25370943
Journal: Int J Oncol. 2015 Feb;46(2):587-96.
Title: Macrophage-secreted IL-8 induces epithelial-mesenchymal transition in hepatocellular carcinoma cells by activating the JAK2/STAT3/Snail pathway.
Author: Fu, Xiu-Tao|Dai, Zhi|Song, Kang|Zhang, Zhuo-Jun|Zhou, Zheng-Jun|Zhou, Shao-Lai|Zhao, Yi-Ming|Xiao, Yong-Sheng|Sun, Qi-Man|Ding, Zhen-Bin|Fan, Jia
PMID: 25405790
Journal: Ann Surg Oncol. 2015 Sep;22(9):3121-9.
Title: TREM-1, an inflammatory modulator, is expressed in hepatocellular carcinoma cells and significantly promotes tumor progression.
Author: Duan, Meng|Wang, Zhi-Chao|Wang, Xiao-Ying|Shi, Jie-Yi|Yang, Liu-Xiao|Ding, Zhen-Bing|Gao, Qiang|Zhou, Jian|Fan, Jia
PMID: 25465376
Journal: EMBO J. 2015 Feb 12;34(4):430-47.
Title: Spontaneous development of hepatocellular carcinoma with cancer stem cell properties in PR-SET7-deficient livers.
Author: Nikolaou, Kostas C|Moulos, Panagiotis|Chalepakis, George|Hatzis, Pantelis|Oda, Hisanobu|Reinberg, Danny|Talianidis, Iannis
PMID: 25515659
Journal: J Gen Virol. 2015 Mar;96(Pt 3):614-25.
Title: C-terminal-truncated hepatitis B virus X protein enhances the development of diethylnitrosamine-induced hepatocellular carcinogenesis.
Author: Quetier, Ivan|Brezillon, Nicolas|Revaud, Julien|Ahodantin, James|DaSilva, Lucie|Soussan, Patrick|Kremsdorf, Dina
PMID: 25519169
Journal: Mol Cells. 2015;38(2):112-21.
Title: 14-3-3zeta regulates immune response through Stat3 signaling in oral squamous cell carcinoma.
Author: Han, Xinguang|Han, Yongfu|Jiao, Huifeng|Jie, Yaqiong
PMID: 25556369
Journal: Clin Cancer Res. 2015 Jan 1;21(1):201-10.
Title: Activation of IL6/IGFIR confers poor prognosis of HBV-related hepatocellular carcinoma through induction of OCT4/NANOG expression.
Author: Chang, Te-Sheng|Wu, Yu-Chih|Chi, Ching-Chi|Su, Wei-Chi|Chang, Pey-Jium|Lee, Kam-Fai|Tung, Tao-Hsin|Wang, Jui|Liu, Jun-Jen|Tung, Shui-Yi|Kuo, Liang-Mou|Ho, Hong-Nerng|Ling, Thai-Yen|Huang, Yen-Hua
PMID: 25564572
Journal: Oncol Rep. 2015 Mar;33(3):1493-8.
Title: STAT3 regulates the migration and invasion of a stemlike subpopulation through microRNA21 and multiple targets in hepatocellular carcinoma.
Author: Zhang, Ning|Duan, Wei-Dong|Leng, Jian-Jun|Zhou, Liang|Wang, Xing|Xu, Yin-Zhe|Wang, Xue-Dong|Zhang, Ai-Qun|Dong, Jia-Hong
PMID: 25571964
Journal: Cancer Res. 2015 Feb 1;75(3):532-43.
Title: Lysophosphatidic acid receptor LPAR6 supports the tumorigenicity of hepatocellular carcinoma.
Author: Mazzocca, Antonio|Dituri, Francesco|De Santis, Flavia|Filannino, Addolorata|Lopane, Chiara|Betz, Regina C|Li, Ying-Yi|Mukaida, Naofumi|Winter, Peter|Tortorella, Cosimo|Giannelli, Gianluigi|Sabba, Carlo
PMID: 25589345
Journal: Chem Biol Interact. 2015 Feb 25;228:108-13.
Title: Copper-obatoclax derivative complexes mediate DNA cleavage and exhibit anti-cancer effects in hepatocellular carcinoma.
Author: Su, Jung-Chen|Chang, Jung-Hua|Huang, Jui-Wen|Chen, Peter P-Y|Chen, Kuen-Feng|Tseng, Ping-Hui|Shiau, Chung-Wai
PMID: 25598309
Journal: Cell Cycle. 2015;14(2):243-52.
Title: miR-146a is directly regulated by STAT3 in human hepatocellular carcinoma cells and involved in anti-tumor immune suppression.
Author: Sun, Xiaoxia|Zhang, Jian|Hou, Zhaohua|Han, Qiuju|Zhang, Cai|Tian, Zhigang
PMID: 25607648
Journal: J Hepatol. 2015 Jun;62(6):1328-40.
Title: Repression of microRNA-130b by thyroid hormone enhances cell motility.
Author: Lin, Yang-Hsiang|Wu, Meng-Han|Liao, Chia-Jung|Huang, Ya-Hui|Chi, Hsiang-Cheng|Wu, Sheng-Ming|Chen, Cheng-Yi|Tseng, Yi-Hsin|Tsai, Chung-Ying|Chung, I-Hsiao|Tsai, Ming-Ming|Chen, Ching-Ying|Lin, Tina P|Yeh, Yung-Hsin|Chen, Wei-Jan|Lin, Kwang-Huei
PMID: 25617495
Journal: Oncogene. 2015 Oct 8;34(41):5252-63.
Title: SHP-1 is a negative regulator of epithelial-mesenchymal transition in hepatocellular carcinoma.
Author: Fan, L-C|Shiau, C-W|Tai, W-T|Hung, M-H|Chu, P-Y|Hsieh, F-S|Lin, H|Yu, H-C|Chen, K-F
PMID: 25619838
Journal: Biomed Pharmacother. 2015 Feb;69:277-84.
Title: Pyruvate kinase M2 affects liver cancer cell behavior through up-regulation of HIF-1alpha and Bcl-xL in culture.
Author: Dong, Tianfu|Yan, Youde|Chai, Hao|Chen, Shenglin|Xiong, Xinkui|Sun, Daoyi|Yu, Yue|Deng, Lei|Cheng, Feng
PMID: 25661370
Journal: Cancer Res. 2015 Apr 15;75(8):1645-56.
Title: High-Mobility Group Box 1 Promotes Hepatocellular Carcinoma Progression through miR-21-Mediated Matrix Metalloproteinase Activity.
Author: Chen, Man|Liu, Yao|Varley, Patrick|Chang, Ying|He, Xing-Xing|Huang, Hai|Tang, Daolin|Lotze, Michael T|Lin, Jusheng|Tsung, Allan
PMID: 25720799
Journal: Cell Death Dis. 2015 Mar 5;6:e1667.
Title: Lack of gp130 expression in hepatocytes attenuates tumor progression in the DEN model.
Author: Hatting, M|Spannbauer, M|Peng, J|Al Masaoudi, M|Sellge, G|Nevzorova, Y A|Gassler, N|Liedtke, C|Cubero, F J|Trautwein, C
PMID: 25741592
Journal: Biochem Biophys Res Commun. 2015 May 29;461(2):366-71.
Title: PML suppresses IL-6-induced STAT3 activation by interfering with STAT3 and HDAC3 interaction.
Author: Kato, Masaya|Muromoto, Ryuta|Togi, Sumihito|Iwakami, Masashi|Kitai, Yuichi|Kon, Shigeyuki|Oritani, Kenji|Matsuda, Tadashi
PMID: 25892518
Journal: BMC Gastroenterol. 2015 Apr 25;15:50.
Title: IL-6, through p-STAT3 rather than p-STAT1, activates hepatocarcinogenesis and affects survival of hepatocellular carcinoma patients: a cohort study.
Author: Kao, Jung-Ta|Feng, Chun-Lung|Yu, Cheng-Ju|Tsai, Shu-Mei|Hsu, Ping-Ning|Chen, Yao-Li|Wu, Yi-Ying
PMID: 25908103
Journal: World J Hepatol. 2015 Apr 18;7(5):777-86.
Title: Hepatitis D and hepatocellular carcinoma.
Author: Abbas, Zaigham|Abbas, Minaam|Abbas, Sarim|Shazi, Lubna
PMID: 25914778
Journal: Oncotarget. 2015 Aug 7;6(22):19055-69.
Title: Galpha12 overexpressed in hepatocellular carcinoma reduces microRNA-122 expression via HNF4alpha inactivation, which causes c-Met induction.
Author: Yang, Yoon Mee|Lee, Chan Gyu|Koo, Ja Hyun|Kim, Tae Hyun|Lee, Jung Min|An, Jihyun|Kim, Kang Mo|Kim, Sang Geon
PMID: 25965999
Journal: PLoS One. 2015 May 29;10(5):e0127356.
Title: Prognostic Role of Phospho-STAT3 in Patients with Cancers of the Digestive System: A Systematic Review and Meta-Analysis.
Author: Li, Mu-xing|Bi, Xin-yu|Huang, Zhen|Zhao, Jian-jun|Han, Yue|Li, Zhi-Yu|Zhang, Ye-fan|Li, Yuan|Chen, Xiao|Hu, Xu-hui|Zhao, Hong|Cai, Jian-qiang
PMID: 26024373
Journal: Biochem Biophys Res Commun. 2015 Jul 31;463(3):389-94.
Title: Ablation of Dicer leads to widespread perturbation of signaling pathways.
Author: Sahasrabuddhe, Nandini A|Huang, Tai-Chung|Kumar, Praveen|Yang, Yi|Ghosh, Bidyut|Leach, Steven D|Chaerkady, Raghothama|Pandey, Akhilesh
PMID: 26032504
Journal: Cancer Res. 2015 Jul 15;75(14):2875-85.
Title: An In Vivo Method to Identify microRNA Targets Not Predicted by Computation Algorithms: p21 Targeting by miR-92a in Cancer.
Author: Su, Xiaoping|Wang, Huaming|Ge, Wei|Yang, Mingjin|Hou, Jin|Chen, Taoyong|Li, Nan|Cao, Xuetao
PMID: 26062558
Journal: Oncotarget. 2015 Sep 8;6(26):22880-9.
Title: Co-expression of CXCL8 and HIF-1alpha is associated with metastasis and poor prognosis in hepatocellular carcinoma.
Author: Li, Xian-Peng|Yang, Xiao-Yu|Biskup, Ewelina|Zhou, Jiang|Li, Hong-Liang|Wu, Yi-Feng|Chen, Ming-Liang|Xu, Feng
PMID: 26078356
Journal: Oncol Rep. 2015 Aug;34(2):795-802.
Title: High expression of IL-9R promotes the progression of human hepatocellular carcinoma and indicates a poor clinical outcome.
Author: Li, Hong-Jun|Sun, Qi-Man|Liu, Long-Zi|Zhang, Jun|Huang, Jun|Wang, Cheng-Hong|Ding, Rui|Song, Kang|Tong, Zhong
PMID: 26082242
Journal: Hepatology. 2015 Oct;62(4):1160-73.
Title: Signal transducer and activator of transcription 3-mediated CD133 up-regulation contributes to promotion of hepatocellular carcinoma.
Author: Won, Cheolhee|Kim, Byung-Hak|Yi, Eun Hee|Choi, Kyung-Ju|Kim, Eun-Kyung|Jeong, Jong-Min|Lee, Jae-Ho|Jang, Ja-June|Yoon, Jung-Hwan|Jeong, Won-Il|Park, In-Chul|Kim, Tae Woo|Bae, Sun Sik|Factor, Valentina M|Ma, Stephanie|Thorgeirsson, Snorri S|Lee, Yun-Han|Ye
PMID: 26154152
Journal: Exp Cell Res. 2015 Sep 10;337(1):53-60.
Title: Long-term use of indomethacin leads to poor prognoses through promoting the expression of PD-1 and PD-L2 via TRIF/NF-kappaB pathway and JAK/STAT3 pathway to inhibit TNF-alpha and IFN-gamma in hepatocellular carcinoma.
Author: Xu, Pingbo|Sun, Zhirong|Wang, Yun|Miao, Changhong
PMID: 26162855
Journal: Cell Res. 2015 Aug;25(8):930-45.
Title: An HNF1alpha-regulated feedback circuit modulates hepatic fibrogenesis via the crosstalk between hepatocytes and hepatic stellate cells.
Author: Qian, Hui|Deng, Xing|Huang, Zhao-Wei|Wei, Ji|Ding, Chen-Hong|Feng, Ren-Xin|Zeng, Xin|Chen, Yue-Xiang|Ding, Jin|Qiu, Lei|Hu, Zhen-Lin|Zhang, Xin|Wang, Hong-Yang|Zhang, Jun-Ping|Xie, Wei-Fen
PMID: 26169608
Journal: Oncotarget. 2015 Sep 22;6(28):26052-64.
Title: Leukemia inhibitory factor protects cholangiocarcinoma cells from drug-induced apoptosis via a PI3K/AKT-dependent Mcl-1 activation.
Author: Morton, Stuart Duncan|Cadamuro, Massimiliano|Brivio, Simone|Vismara, Marta|Stecca, Tommaso|Massani, Marco|Bassi, Nicolo|Furlanetto, Alberto|Joplin, Ruth Elizabeth|Floreani, Annarosa|Fabris, Luca|Strazzabosco, Mario
PMID: 26296968
Journal: Neoplasia. 2015 Jul;17(7):586-97.
Title: Predominant Activation of JAK/STAT3 Pathway by Interleukin-6 Is Implicated in Hepatocarcinogenesis.
Author: Jung, In Hye|Choi, Jeffrey Hyun-Kyu|Chung, Yong-Yoon|Lim, Ga-Lam|Park, Young-Nyun|Park, Seung Woo
PMID: 26297436
Journal: Nucleic Acids Res. 2015 Dec 15;43(22):10673-88.
Title: Profiling of promoter occupancy by the SND1 transcriptional coactivator identifies downstream glycerolipid metabolic genes involved in TNFalpha response in human hepatoma cells.
Author: Arretxe, Enara|Armengol, Sandra|Mula, Sarai|Chico, Yolanda|Ochoa, Begona|Martinez, Maria Jose
PMID: 26323317
Journal: Exp Mol Pathol. 2015 Dec;99(3):474-84.
Title: HES5 promotes cell proliferation and invasion through activation of STAT3 and predicts poor survival in hepatocellular carcinoma.
Author: Zhu, Guizhou|Shi, Weidong|Fan, Hui|Zhang, Xiubing|Xu, Jian|Chen, Yongmei|Xu, Zhiwei|Tao, Tao|Cheng, Chun
PMID: 26342546
Journal: Onco Targets Ther. 2015 Aug 21;8:2215-25.
Title: The influence of TLR4 agonist lipopolysaccharides on hepatocellular carcinoma cells and the feasibility of its application in treating liver cancer.
Author: Gu, Junsheng|Sun, Ranran|Shen, Shen|Yu, Zujiang
PMID: 26345468
Journal: J Virol. 2015 Nov;89(22):11549-56.
Title: Promotion of Cancer Stem-Like Cell Properties in Hepatitis C Virus-Infected Hepatocytes.
Author: Kwon, Young-Chan|Bose, Sandip K|Steele, Robert|Meyer, Keith|Di Bisceglie, Adrian M|Ray, Ratna B|Ray, Ranjit
PMID: 26355082
Journal: Egypt J Immunol. 2015;22(1):59-68.
Title: IL-17 Producing Cells and RORgammat mRNA Transcriptional Factor in Cirrhotic and HCC Egyptian Patients.
Author: El Bassuoni, M A|Soliman, M A|El Megeed, N A|Al Gazar, A
PMID: 26415373
Journal: J Exp Clin Cancer Res. 2015 Oct 9;34:116.
Title: Long noncoding RNA lncTCF7, induced by IL-6/STAT3 transactivation, promotes hepatocellular carcinoma aggressiveness through epithelial-mesenchymal transition.
Author: Wu, Jun|Zhang, Jun|Shen, Bin|Yin, Kai|Xu, Jianwei|Gao, Wencan|Zhang, Lihong
PMID: 26452542
Journal: Life Sci. 2015 Dec 1;142:19-25.
Title: Molecular mechanisms underlying anticancer effects of myricetin.
Author: Devi, Kasi Pandima|Rajavel, Tamilselvam|Habtemariam, Solomon|Nabavi, Seyed Fazel|Nabavi, Seyed Mohammad
PMID: 26455550
Journal: J Clin Invest. 2015 Nov 2;125(11):4239-54.
Title: STK4 regulates TLR pathways and protects against chronic inflammation-related hepatocellular carcinoma.
Author: Li, Weiyun|Xiao, Jun|Zhou, Xin|Xu, Ming|Hu, Chaobo|Xu, Xiaoyan|Lu, Yao|Liu, Chang|Xue, Shengjie|Nie, Lei|Zhang, Haibin|Li, Zhiqi|Zhang, Yanbo|Ji, Fu|Hui, Lijian|Tao, Wufan|Wei, Bin|Wang, Hongyan
PMID: 26457732
Journal: Am J Physiol Gastrointest Liver Physiol. 2015 Dec 15;309(12):G942-54.
Title: Loss of hepatocyte ERBB3 but not EGFR impairs hepatocarcinogenesis.
Author: Scheving, Lawrence A|Zhang, Xiuqi|Stevenson, Mary C|Weintraub, Michael A|Abbasi, Annam|Clarke, Andrea M|Threadgill, David W|Russell, William E
PMID: 26492920
Journal: Int J Oncol. 2015 Dec;47(6):2131-40.
Title: Targeted silencing of CXCL1 by siRNA inhibits tumor growth and apoptosis in hepatocellular carcinoma.
Author: Han, Ke-Qi|He, Xue-Qun|Ma, Meng-Yu|Guo, Xiao-Dong|Zhang, Xue-Min|Chen, Jie|Han, Hui|Zhang, Wei-Wei|Zhu, Quan-Gang|Zhao, Wen-Zhao
PMID: 26499374
Journal: BMC Cancer. 2015 Nov 2;15:830.
Title: Higher proliferation of peritumoral endothelial cells to IL-6/sIL-6R than tumoral endothelial cells in hepatocellular carcinoma.
Author: Zhuang, Peng-Yuan|Wang, Jian-Dong|Tang, Zhao-Hui|Zhou, Xue-Ping|Quan, Zhi-Wei|Liu, Ying-Bin|Shen, Jun
PMID: 26525581
Journal: Epigenetics. 2015;10(12):1099-110.
Title: Stat3 is a candidate epigenetic biomarker of perinatal Bisphenol A exposure associated with murine hepatic tumors with implications for human health.
Author: Weinhouse, Caren|Bergin, Ingrid L|Harris, Craig|Dolinoy, Dana C
PMID: 26542749
Journal: PLoS One. 2015 Nov 16;10(11):e0143042.
Title: Hepatocyte-Specific Arid1a Deficiency Initiates Mouse Steatohepatitis and Hepatocellular Carcinoma.
Author: Fang, Jia-Zhu|Li, Chong|Liu, Xiao-Yan|Hu, Tao-Tao|Fan, Zu-Sen|Han, Ze-Guang
PMID: 26569409
Journal: J Transl Med. 2015 Nov 22;13:365.
Title: Activated hepatic stellate cells promote angiogenesis via interleukin-8 in hepatocellular carcinoma.
Author: Zhu, Bing|Lin, Nan|Zhang, Min|Zhu, Yong|Cheng, Huanhuan|Chen, Shuxian|Ling, Yunbiao|Pan, Weidong|Xu, Ruiyun
PMID: 26593962
Journal: Int J Nanomedicine. 2015 Nov 18;10:7129-43.
Title: Combination of PEI-Mn0.5Zn0.5Fe2O4 nanoparticles and pHsp 70-HSV-TK/GCV with magnet-induced heating for treatment of hepatoma.
Author: Tang, Qiusha|Lu, Mudan|Chen, Daozhen|Liu, Peidang
PMID: 26604760
Journal: Int J Clin Exp Med. 2015 Sep 15;8(9):16955-9. eCollection 2015.
Title: Hydroxyflavanone inhibits gastric carcinoma MGC-803 cell proliferation.
Author: Zhang, Haiyan|Zhan, Zhuo|Cui, Mingfu|Gao, Yongjian|Wang, Dayu|Feng, Ye
PMID: 26629250
Journal: PLoS One. 2015 Dec 11;10(12):e0141655.
Title: IFN-lambda Inhibits MiR-122 Transcription through a Stat3-HNF4alpha Inflammatory Feedback Loop in an IFN-alpha Resistant HCV Cell Culture System.
Author: Aboulnasr, Fatma|Hazari, Sidhartha|Nayak, Satyam|Chandra, Partha K|Panigrahi, Rajesh|Ferraris, Pauline|Chava, Srinivas|Kurt, Ramazan|Song, Kyongsub|Dash, Asha|Balart, Luis A|Garry, Robert F|Wu, Tong|Dash, Srikanta
PMID: 26657215
Journal: Mol Carcinog. 2016 May;55(5):659-70.
Title: Anti-cancer effect of N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2,3-dihydronaphtho[1,2-b]furan-2-carb oxamide, a novel synthetic compound.
Author: Kwon, Sun Mi|Jung, Yu Yeon|Hwang, Chul Ju|Park, Mi Hee|Yoon, Na Young|Kim, Tae Myung|Yu, Ji Myung|Kim, Dae Hwan|Seo, Doo Won|Youn, Hyu Seok|Seo, Hyun Ok|Chung, In Sung|Han, Sang Bae|Hwang, Bang Yeon|Yoo, Hwan-Soo|Jung, Jae-Kyung|Lee, Heesoon|Hong, Jin Tae
PMID: 25865242
Journal: Scand J Immunol. 2016 Jan;83(1):33-7.
Title: CCL20-CCR6 Cytokine Network Facilitate Treg Activity in Advanced Grades and Metastatic Variants of Hepatocellular Carcinoma.
Author: Li, W-M|Liu, H-R
PMID: 26331965
Journal: Gastroenterology. 2016 Mar;150(3):707-19.
Title: TLR4 Signaling via NANOG Cooperates With STAT3 to Activate Twist1 and Promote Formation of Tumor-Initiating Stem-Like Cells in Livers of Mice.
Author: Uthaya Kumar, Dinesh Babu|Chen, Chia-Lin|Liu, Jian-Chang|Feldman, Douglas E|Sher, Linda S|French, Samuel|DiNorcia, Joseph|French, Samuel W|Naini, Bita V|Junrungsee, Sunhawit|Agopian, Vatche Garen|Zarrinpar, Ali|Machida, Keigo
PMID: 26582088
Journal: Cancer Lett. 2016 Feb 28;371(2):205-13.
Title: A combination of sorafenib and SC-43 is a synergistic SHP-1 agonist duo to advance hepatocellular carcinoma therapy.
Author: Chao, Tzu-I|Tai, Wei-Tien|Hung, Man-Hsin|Tsai, Ming-Hsien|Chen, Min-Hsuan|Chang, Mao-Ju|Shiau, Chung-Wai|Chen, Kuen-Feng
PMID: 26679051
Journal: Oncotarget. 2016 Jan 26;7(4):4664-79.
Title: Emodin potentiates the antiproliferative effect of interferon alpha/beta by activation of JAK/STAT pathway signaling through inhibition of the 26S proteasome.
Author: He, Yujiao|Huang, Junmei|Wang, Ping|Shen, Xiaofei|Li, Sheng|Yang, Lijuan|Liu, Wanli|Suksamrarn, Apichart|Zhang, Guolin|Wang, Fei
PMID: 26683360
Journal: Oncotarget. 2016 Feb 2;7(5):5461-9.
Title: Activating JAK1 mutation may predict the sensitivity of JAK-STAT inhibition in hepatocellular carcinoma.
Author: Yang, Shuqun|Luo, Chonglin|Gu, Qingyang|Xu, Qiang|Wang, Guan|Sun, Hongye|Qian, Ziliang|Tan, Yexiong|Qin, Yuxin|Shen, Yuhong|Xu, Xiaowei|Chen, Shu-Hui|Chan, Chi-Chung|Wang, Hongyang|Mao, Mao|Fang, Douglas D
PMID: 26701727
Journal: Sci Rep. 2016 Jan 13;6:18528.
Title: Cytokine levels contribute to the pathogenesis of minimal hepatic encephalopathy in patients with hepatocellular carcinoma via STAT3 activation.
Author: Wu, Hao|Li, Ning|Jin, Ronghua|Meng, Qinghua|Chen, Peng|Zhao, Guoxian|Wang, Rui|Li, Li|Li, Wei
PMID: 26757951
Journal: Ann Surg Oncol. 2016 Dec;23(Suppl 5):574-582.
Title: Autologous Tumor Cell Lysate-Loaded Dendritic Cell Vaccine Inhibited Tumor Progression in an Orthotopic Murine Model for Hepatocellular Carcinoma.
Author: Wang, Qin|Luan, Wei|Warren, Leslie|Kadri, Hena|Kim, Ki Won|Goz, Vadim|Blank, Sima|Isabel Fiel, M|Hiotis, Spiros P
PMID: 26786094
Journal: Cell Death Differ. 2016 Apr;23(4):616-27.
Title: HBV-induced ROS accumulation promotes hepatocarcinogenesis through Snail-mediated epigenetic silencing of SOCS3.
Author: Yuan, K|Lei, Y|Chen, H-N|Chen, Y|Zhang, T|Li, K|Xie, N|Wang, K|Feng, X|Pu, Q|Yang, W|Wu, M|Xiang, R|Nice, E C|Wei, Y|Huang, C
PMID: 26794444
Journal: J Hepatol. 2016 Jun;64(6):1283-94.
Title: Long non-coding RNA DILC regulates liver cancer stem cells via IL-6/STAT3 axis.
Author: Wang, Xue|Sun, Wen|Shen, Weifeng|Xia, Mingyang|Chen, Cheng|Xiang, Daimin|Ning, Beifang|Cui, Xiuliang|Li, Hengyu|Li, Xiaofeng|Ding, Jin|Wang, Hongyang
PMID: 26812074
Journal: Stem Cells. 2016 May;34(5):1188-97.
Title: Peroxiredoxin II Is Essential for Maintaining Stemness by Redox Regulation in Liver Cancer Cells.
Author: Kwon, Taeho|Bak, Yesol|Park, Young-Ho|Jang, Gyu-Beom|Nam, Jeong-Seok|Yoo, Jeong Eun|Park, Young Nyun|Bak, In Seon|Kim, Jin-Man|Yoon, Do-Young|Yu, Dae-Yeul
PMID: 26866938
Journal: J Med Virol. 2016 Sep;88(9):1552-9.
Title: Differential association of STAT3 and HK-II expression in hepatitis B virus- and hepatitis C virus-related hepatocellular carcinoma.
Author: Li, Man|Wang, Weihua|Jin, Rui|Zhang, Tieying|Li, Na|Han, Qunying|Wei, Ping|Liu, Zhengwen
PMID: 26889748
Journal: Oncogenesis. 2016 Feb 22;5:e198.
Title: Hepatic carcinoma-associated fibroblasts induce IDO-producing regulatory dendritic cells through IL-6-mediated STAT3 activation.
Author: Cheng, J-T|Deng, Y-N|Yi, H-M|Wang, G-Y|Fu, B-S|Chen, W-J|Liu, W|Tai, Y|Peng, Y-W|Zhang, Q
PMID: 26900950
Journal: Cancer Biol Ther. 2016 Apr 2;17(4):449-56.
Title: Targeting blockage of STAT3 inhibits hepatitis B virus-related hepatocellular carcinoma.
Author: Yang, Yinli|Zheng, Bingqing|Han, Qiuju|Zhang, Cai|Tian, Zhigang|Zhang, Jian
PMID: 26934469
Journal: Curr Pharm Des. 2016;22(34):5257-5269.
Title: Circulating microRNAs in Hepatocellular Carcinoma: Potential Diagnostic and Prognostic Biomarkers.
Author: Mirzaei, Hamid Reza|Sahebkar, Amirhossein|Mohammadi, Mohsen|Yari, Reza|Salehi, Hossein|Jafari, Mohammad Hasan|Namdar, Afshin|Khabazian, Ehsan|Jaafari, Mahmoud Reza|Mirzaei, Hamed
PMID: 26935703
Journal: Oncol Rep. 2016 May;35(5):2952-62.
Title: Reversal of liver cancer-associated stellate cell-induced stem-like characteristics in SMMC-7721 cells by 8-bromo-7-methoxychrysin via inhibiting STAT3 activation.
Author: Cui, Yinghong|Sun, Shuwen|Ren, Kaiqun|Quan, Meifang|Song, Zhenwei|Zou, Hui|Li, Duo|Cao, Jianguo
PMID: 26935885
Journal: Int J Radiat Oncol Biol Phys. 2016 Jun 1;95(2):761-71.
Title: Dovitinib Acts As a Novel Radiosensitizer in Hepatocellular Carcinoma by Targeting SHP-1/STAT3 Signaling.
Author: Huang, Chao-Yuan|Tai, Wei-Tien|Wu, Szu-Yuan|Shih, Chih-Ting|Chen, Min-Hsuan|Tsai, Ming-Hsien|Kuo, Chiung-Wen|Shiau, Chung-Wai|Hung, Man-Hsin|Chen, Kuen-Feng
PMID: 26960749
Journal: PLoS One. 2016 Mar 14;11(3):e0151679.
Title: RY10-4 Inhibits the Proliferation of Human Hepatocellular Cancer HepG2 Cells by Inducing Apoptosis In Vitro and In Vivo.
Author: Zhang, Xuenong|Wang, Yanyan|Han, Shishi|Xiang, Huiyao|Peng, Yan|Wu, Yinghua|Pan, Songwei|Zhang, Ye|Ruan, Jinlan
PMID: 26974964
Journal: PLoS One. 2016 Mar 16;11(3):e0151455.
Title: Estradiol and Estrogen Receptor Agonists Oppose Oncogenic Actions of Leptin in HepG2 Cells.
Author: Shen, Minqian|Shi, Haifei
PMID: 26982332
Journal: Cancer Lett. 2016 Jun 1;375(2):390-399.
Title: Non-CSCs nourish CSCs through interleukin-17E-mediated activation of NF-kappaB and JAK/STAT3 signaling in human hepatocellular carcinoma.
Author: Luo, Yongli|Yang, Zhi|Su, Li|Shan, Juanjuan|Xu, Huailong|Xu, Yanmin|Liu, Limei|Zhu, Wei|Chen, Xuejiao|Liu, Chungang|Chen, Jun|Yao, Chao|Cheng, Feifei|Zhang, Chengcheng|Ma, Qinghua|Shen, Junjie|Qian, Cheng
PMID: 27000993
Journal: Oncotarget. 2016 Apr 26;7(17):24005-17.
Title: C-terminal truncated hepatitis B virus X protein promotes hepatocellular carcinogenesis through induction of cancer and stem cell-like properties.
Author: Ng, Kai-Yu|Chai, Stella|Tong, Man|Guan, Xin-Yuan|Lin, Chi-Ho|Ching, Yick-Pang|Xie, Dan|Cheng, Alfred Sze-Lok|Ma, Stephanie
PMID: 27006468
Journal: Sci Rep. 2016 Mar 24;6:23269.
Title: Regulation of Multi-drug Resistance in hepatocellular carcinoma cells is TRPC6/Calcium Dependent.
Author: Wen, Liang|Liang, Chao|Chen, Enjiang|Chen, Wei|Liang, Feng|Zhi, Xiao|Wei, Tao|Xue, Fei|Li, Guogang|Yang, Qi|Gong, Weihua|Feng, Xinhua|Bai, Xueli|Liang, Tingbo
PMID: 27011063
Journal: Free Radic Res. 2016 Jul;50(7):744-55.
Title: Inhibiting ROS-STAT3-dependent autophagy enhanced capsaicin-induced apoptosis in human hepatocellular carcinoma cells.
Author: Chen, Xun|Tan, Miduo|Xie, Zhiqin|Feng, Bin|Zhao, Zhijian|Yang, Kaiqing|Hu, Chen|Liao, Ni|Wang, Taoli|Chen, Dongliang|Xie, Feng|Tang, Caixi
PMID: 27043357
Journal: Oncoimmunology. 2015 Aug 12;5(2):e1074376.
Title: TLR4 signaling promotes a COX-2/PGE2/STAT3 positive feedback loop in hepatocellular carcinoma (HCC) cells.
Author: Lin, Ang|Wang, Guan|Zhao, Huajun|Zhang, Yuyi|Han, Qiuju|Zhang, Cai|Tian, Zhigang|Zhang, Jian
PMID: 27057441
Journal: Sci Rep. 2016 Apr 15;6:24397.
Title: Recombinant soluble gp130 protein reduces DEN-induced primary hepatocellular carcinoma in mice.
Author: Hong, Jing|Wang, Hang|Shen, Guoying|Lin, Da|Lin, Yanxue|Ye, Nanhui|Guo, Yashan|Li, Qiaoling|Ye, Nanhui|Deng, Chengjun|Meng, Chun
PMID: 27080032
Journal: Oncotarget. 2016 May 17;7(20):29465-79.
Title: Human growth hormone and human prolactin function as autocrine/paracrine promoters of progression of hepatocellular carcinoma.
Author: Kong, Xiangjun|Wu, Wenyong|Yuan, Yan|Pandey, Vijay|Wu, Zhengsheng|Lu, Xuefei|Zhang, Weijie|Chen, Yijun|Wu, Mingming|Zhang, Min|Li, Gaopeng|Tan, Sheng|Qian, Pengxu|Perry, Jo K|Lobie, Peter E|Zhu, Tao
PMID: 27102295
Journal: Mol Cell Biochem. 2016 May;416(1-2):85-97.
Title: Metastasized lung cancer suppression by Morinda citrifolia (Noni) leaf compared to Erlotinib via anti-inflammatory, endogenous antioxidant responses and apoptotic gene activation.
Author: Lim, Swee-Ling|Mustapha, Noordin M|Goh, Yong-Meng|Bakar, Nurul Ain Abu|Mohamed, Suhaila
PMID: 27106908
Journal: Cancer Lett. 2016 Jul 28;377(2):117-25.
Title: Polysaccharide from Lentinus edodes combined with oxaliplatin possesses the synergy and attenuation effect in hepatocellular carcinoma.
Author: Zhang, Yu|Li, Qiang|Wang, Junfeng|Cheng, Fang|Huang, Xiao|Cheng, Yao|Wang, Kaiping
PMID: 27130669
Journal: Acta Pharmacol Sin. 2016 Jun;37(6):805-13.
Title: Protrusion-localized STAT3 mRNA promotes metastasis of highly metastatic hepatocellular carcinoma cells in vitro.
Author: Liu, Yan-Hong|Jin, Jia-Lu|Wang, Yu-Zhe|Tan, Ying|Zhou, Ying-Ying|Peng, Ting|Li, Feng|Liang, Wan-Dong|Chartrand, Pascal|Jiang, Yu-Yang|Shen, Zhi-Fa
PMID: 27133294
Journal: Cell. 2016 May 5;165(4):896-909.
Title: Lung Adenocarcinoma Distally Rewires Hepatic Circadian Homeostasis.
Author: Masri, Selma|Papagiannakopoulos, Thales|Kinouchi, Kenichiro|Liu, Yu|Cervantes, Marlene|Baldi, Pierre|Jacks, Tyler|Sassone-Corsi, Paolo
PMID: 27153497
Journal: Am J Transl Res. 2016 Mar 15;8(3):1319-38. eCollection 2016.
Title: Overexpression of variant PNPLA3 gene at I148M position causes malignant transformation of hepatocytes via IL-6-JAK2/STAT3 pathway in low dose free fatty acid exposure: a laboratory investigation in vitro and in vivo.
Author: Liu, Zhengtao|Chen, Tianchi|Lu, Xiaoxiao|Xie, Haiyang|Zhou, Lin|Zheng, Shusen
PMID: 27186262
Journal: Oncotarget. 2016 Jul 5;7(27):41445-41459.
Title: RhoE/ROCK2 regulates chemoresistance through NF-kappaB/IL-6/ STAT3 signaling in hepatocellular carcinoma.
Author: Ma, Wei|Sze, Karen Man-Fong|Chan, Lo Kong|Lee, Joyce Man-Fong|Wei, Larry Lai|Wong, Chun-Ming|Lee, Terence Kin-Wah|Wong, Carmen Chak-Lui|Ng, Irene Oi-Lin
PMID: 27213590
Journal: Cancer Res. 2016 Jul 15;76(14):4124-35.
Title: FAP Promotes Immunosuppression by Cancer-Associated Fibroblasts in the Tumor Microenvironment via STAT3-CCL2 Signaling.
Author: Yang, Xuguang|Lin, Yuli|Shi, Yinghong|Li, Bingji|Liu, Weiren|Yin, Wei|Dang, Yongjun|Chu, Yiwei|Fan, Jia|He, Rui
PMID: 27216177
Journal: Eur Rev Med Pharmacol Sci. 2016 May;20(10):2020-7.
Title: MiR-183 modulates multi-drug resistance in hepatocellular cancer (HCC) cells via miR-183-IDH2/SOCS6-HIF-1alpha feedback loop.
Author: Wang, X-J|Zhang, D-L|Fu, C|Wei, B-Z|Li, G-J
PMID: 27249600
Journal: Oncotarget. 2016 Jul 12;7(28):43475-43491.
Title: (-)-Oleocanthal inhibits growth and metastasis by blocking activation of STAT3 in human hepatocellular carcinoma.
Author: Pei, Tiemin|Meng, Qinghui|Han, Jihua|Sun, Haobo|Li, Long|Song, Ruipeng|Sun, Boshi|Pan, Shangha|Liang, Desen|Liu, Lianxin
PMID: 27259268
Journal: Hepatobiliary Surg Nutr. 2016 Jun;5(3):201-3.
Title: STAT3 is a key transcriptional regulator of cancer stem cell marker CD133 in HCC.
Author: Ghoshal, Sarani|Fuchs, Bryan C|Tanabe, Kenneth K
PMID: 27275460
Journal: Neoplasia. 2016 Jun;18(6):371-86.
Title: A Positive TGF-beta/c-KIT Feedback Loop Drives Tumor Progression in Advanced Primary Liver Cancer.
Author: Rojas, Andres|Zhang, Pingyu|Wang, Ying|Foo, Wai Chin|Munoz, Nina M|Xiao, Lianchun|Wang, Jing|Gores, Gregory J|Hung, Mien-Chie|Blechacz, Boris
PMID: 27292026
Journal: Cell Signal. 2016 Sep;28(9):1314-24.
Title: IL-6/STAT3 axis initiated CAFs via up-regulating TIMP-1 which was attenuated by acetylation of STAT3 induced by PCAF in HCC microenvironment.
Author: Zheng, Xin|Xu, Meng|Yao, Bowen|Wang, Cong|Jia, Yuli|Liu, Qingguang
PMID: 27297362
Journal: Int J Oncol. 2016 Sep;49(3):971-80.
Title: Sustainable inflammation transforms hepatic cells by causing oxidative stress injury and potential epithelial-mesenchymal transition.
Author: Lu, Kun|Liu, Guoyan|Yang, Ling|Liu, Fan|Gao, Libin|Shi, Jingxian|Deng, Xiaoling|Li, Qifu|Xu, Donghui|Shi, Songlin
PMID: 27315196
Journal: Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2016 Jul;32(7):901-5.
Title: [Interferon-beta combined with all-trans retinoic acid supresses proliferation and promote apoptosis by inhibiting JAK2/STAT3 pathway in HepG2 human hepatocellular carcinoma cells].
Author: Zhao, Jian|Nie, Wenjia|Li, Wei|Zhou, Xiaohui|Sun, Huifeng|Zhu, Junqing|Chen, Jinjun|Peng, Junlu
PMID: 27363269
Journal: J Immunother Cancer. 2016 Jul 19;4:40.
Title: B cell regulation of the anti-tumor response and role in carcinogenesis.
Author: Schwartz, Marc|Zhang, Yu|Rosenblatt, Joseph D
PMID: 27437104
Journal: Sci Rep. 2016 Jul 26;6:30404.
Title: Autocrine activity of BDNF induced by the STAT3 signaling pathway causes prolonged TrkB activation and promotes human non-small-cell lung cancer proliferation.
Author: Chen, Bo|Liang, Yan|He, Zheng|An, Yunhe|Zhao, Weihong|Wu, Jianqing
PMID: 27456333
Journal: Oncol Rep. 2016 Sep;36(3):1483-90.
Title: Effect of saracatinib on pulmonary metastases from hepatocellular carcinoma.
Author: Xiong, Ju|Wu, Jin-Sheng|Mao, Shan-Shan|Yu, Xiang-Nan|Huang, Xiao-Xi
PMID: 27460949
Journal: Cell Physiol Biochem. 2016;39(2):768-79.
Title: NEDD4 Depletion Inhibits Hepatocellular Carcinoma Growth via Targeting PTEN.
Author: Hang, Xiaofeng|Zhu, Shanbang|Di, Hongwei|Wu, Zhiqin|Chu, Kaijian|Wang, Junxue|Xin, Haiguang|Yu, Guanzhen|Peng, Haoran|Miao, Xiaohui|Xu, Wensheng
PMID: 27467187
Journal: Int J Biochem Cell Biol. 2016 Sep;78:315-326.
Title: Hepatitis C virus suppresses Hepatocyte Nuclear Factor 4 alpha, a key regulator of hepatocellular carcinoma.
Author: Vallianou, Ioanna|Dafou, Dimitra|Vassilaki, Niki|Mavromara, Penelope|Hadzopoulou-Cladaras, Margarita
PMID: 27477312
Journal: Cancer Discov. 2016 Oct;6(10):1182-1195.
Title: Polarization of Tissue-Resident TFH-Like Cells in Human Hepatoma Bridges Innate Monocyte Inflammation and M2b Macrophage Polarization.
Author: Chen, Min-Min|Xiao, Xiao|Lao, Xiang-Ming|Wei, Yuan|Liu, Rui-Xian|Zeng, Qiu-Hui|Wang, Jun-Cheng|Ouyang, Fang-Zhu|Chen, Dong-Ping|Chan, Ka-Wo|Shi, Dai-Chao|Zheng, Limin|Kuang, Dong-Ming
PMID: 27531854
Journal: Nat Commun. 2016 Aug 24;7:12598.
Title: LncSox4 promotes the self-renewal of liver tumour-initiating cells through Stat3-mediated Sox4 expression.
Author: Chen, Zhen-Zhen|Huang, Lan|Wu, Ya-Hong|Zhai, Wen-Jie|Zhu, Ping-Ping|Gao, Yan-Feng
PMID: 27553854
Journal: Tumour Biol. 2016 Nov;37(11):14629-14635.
Title: U/G SNP rs111904020 in 3'UTR of STAT3 regulated by miR-214 promotes hepatocellular carcinoma development in Chinese population.
Author: Fan, Ye|Qian, Xiaofeng|Zhang, Chuanyong
PMID: 27619679
Journal: Mol Ther Oncolytics. 2016 Apr 27;3:16012.
Title: Tumor control by human cytomegalovirus in a murine model of hepatocellular carcinoma.
Author: Kumar, Amit|Coquard, Laurie|Pasquereau, Sebastien|Russo, Laetitia|Valmary-Degano, Severine|Borg, Christophe|Pothier, Pierre|Herbein, Georges
PMID: 27626063
Journal: Adv Exp Med Biol. 2016;928:435-452.
Title: Garcinol and Its Role in Chronic Diseases.
Author: Behera, Amit K|Swamy, Mahadeva M|Natesh, Nagashayana|Kundu, Tapas K
PMID: 27671827
Journal: Life Sci. 2016 Dec 1;166:34-40.
Title: microRNA-539 suppresses tumor growth and tumorigenesis and overcomes arsenic trioxide resistance in hepatocellular carcinoma.
Author: Zhu, Chuanying|Zhou, Renhua|Zhou, Qing|Chang, Yuewen|Jiang, Mawei
PMID: 27717846
Journal: Sci Rep. 2016 Oct 13;6:34740.
Title: MicroRNA miR-204 and miR-1236 inhibit hepatitis B virus replication via two different mechanisms.
Author: Huang, Jyun-Yuan|Chen, Hung-Lin|Shih, Chiaho
PMID: 27734898
Journal: PLoS One. 2016 Oct 19;11(10):e0164087.
Title: Role of PXR in Hepatic Cancer: Its Influences on Liver Detoxification Capacity and Cancer Progression.
Author: Kotiya, Deepak|Jaiswal, Bharti|Ghose, Sampa|Kaul, Rachna|Datta, Kasturi|Tyagi, Rakesh K
PMID: 27760163
Journal: Mol Cancer Ther. 2016 Dec;15(12):2966-2976.
Title: Ascochlorin Enhances the Sensitivity of Doxorubicin Leading to the Reversal of Epithelial-to-Mesenchymal Transition in Hepatocellular Carcinoma.
Author: Dai, Xiaoyun|Ahn, Kwang Seok|Wang, Ling Zhi|Kim, Chulwon|Deivasigamni, Amudha|Arfuso, Frank|Um, Jae-Young|Kumar, Alan Prem|Chang, Young-Chae|Kumar, Dhiraj|Kundu, Gopal C|Magae, Junji|Goh, Boon Cher|Hui, Kam Man|Sethi, Gautam
PMID: 27765853
Journal: Eur Rev Med Pharmacol Sci. 2016 Oct;20(19):3953-3954.
Title: Editorial - PHACTR4/STAT3 axis as a possible target therapy for hepatocellular carcinoma treatment.
Author: Li Volti, G|Zanghi, A|Zanghi, G
PMID: 27775809
Journal: Biomed Pharmacother. 2016 Dec;84:1202-1212.
Title: The effect of JAK2 knockout on inhibition of liver tumor growth by inducing apoptosis, autophagy and anti-proliferation via STATs and PI3K/AKT signaling pathways.
Author: Xu, Ying|Lv, Sheng-Xiang
PMID: 27788478
Journal: PLoS One. 2016 Nov 7;11(11):e0166172.
Title: APPL1-Mediating Leptin Signaling Contributes to Proliferation and Migration of Cancer Cells.
Author: Ding, Youming|Cao, Yingkang|Wang, Bin|Wang, Lei|Zhang, Yemin|Zhang, Deling|Chen, Xiaoyan|Li, Mingxin|Wang, Changhua
PMID: 27820851
Journal: Oncotarget. 2016 Nov 29;7(48):79453-79473.
Title: Investigating the mechanism of hepatocellular carcinoma progression by constructing genetic and epigenetic networks using NGS data identification and big database mining method.
Author: Li, Cheng-Wei|Chang, Ping-Yao|Chen, Bor-Sen
PMID: 27821810
Journal: Molecules. 2016 Nov 10;21(11). pii: molecules21111507.
Title: TTF1, in the Form of Nanoparticles, Inhibits Angiogenesis, Cell Migration and Cell Invasion In Vitro and In Vivo in Human Hepatoma through STAT3 Regulation.
Author: Xiao, Bin|Lin, Dongjing|Zhang, Xuan|Zhang, Meilan|Zhang, Xuewu
PMID: 27834930
Journal: Am J Transl Res. 2016 Nov 15;8(11):4670-4681. eCollection 2016.
Title: eIF5A2 is an alternative pathway for cell proliferation in cetuximab-treated epithelial hepatocellular carcinoma.
Author: Xue, Fei|Liu, Yanhui|Chu, Haoyuan|Wen, Yu|Yan, Lei|Tang, Qiang|Xiao, Erhui|Zhang, Dongyi|Zhang, Hongwei
PMID: 27904670
Journal: Nat Commun. 2016 Dec 21;7:13781.
Title: A cell-autonomous tumour suppressor role of RAF1 in hepatocarcinogenesis.
Author: Jeric, Ines|Maurer, Gabriele|Cavallo, Anna Lina|Raguz, Josipa|Desideri, Enrico|Tarkowski, Bartosz|Parrini, Matthias|Fischer, Irmgard|Zatloukal, Kurt|Baccarini, Manuela
PMID: 28000790
Journal: Crit Rev Oncog. 2016;21(5-6):413-432.
Title: Antitumoral Activity of Sorafenib in Hepatocellular Carcinoma: Effects on Cell Survival and Death Pathways, Cell Metabolism Reprogramming, and Nitrosative and Oxidative Stress.
Author: Molina-Ruiz, Francisco J|Gonzalez, Raul|Rodriguez-Hernandez, Maria A|Navarro-Villaran, Elena|Padillo, Francisco J|Muntane, Jordi
PMID: 29431086
Journal: Yao Xue Xue Bao. 2016 Dec;51(12):1845-51.
Title: [Apoptosis of human hepatocellular carcinoma HepG-2 cells upon inhibition of STAT3 by 5,2',4'-trihydroxy-6,7,5'-trimethoxy flavone nanoparticle].
Author: Xiao, Bin|Zhang, Xuan|Zhang, Mei-lan|Zhang, Xue-wu
PMID: 29908536
Journal: Oncotarget. 2017 Mar 14;8(11):17593-17609.
Title: The neuroleptic drug pimozide inhibits stem-like cell maintenance and tumorigenicity in hepatocellular carcinoma.
Author: Chen, Jia-Jie|Cai, Nan|Chen, Guan-Zhong|Jia, Chang-Chang|Qiu, Dong-Bo|Du, Cong|Liu, Wei|Yang, Yang|Long, Zi-Jie|Zhang, Qi
PMID: 26061710
Journal: Oncotarget. 2017 Jan 24;8(4):5800-5813.
Title: Cucurbitacin B exerts anti-cancer activities in human multiple myeloma cells in vitro and in vivo by modulating multiple cellular pathways.
Author: Yang, Tai|Liu, Jin|Yang, Mali|Huang, Ning|Zhong, Yueling|Zeng, Ting|Wei, Rong|Wu, Zhongjun|Xiao, Cui|Cao, Xiaohua|Li, Minhui|Li, Limei|Han, Bin|Yu, Xiaoping|Li, Hua|Zou, Qiang
PMID: 27418139
Journal: Oncogene. 2017 Feb 23;36(8):1069-1079.
Title: Stat3 contributes to cancer progression by regulating Jab1/Csn5 expression.
Author: Pan, Y|Wang, S|Su, B|Zhou, F|Zhang, R|Xu, T|Zhang, R|Leventaki, V|Drakos, E|Liu, W|Claret, F X
PMID: 27524414
Journal: Oncogene. 2017 Feb 23;36(8):1090-1101.
Title: Hepatic carcinoma-associated fibroblasts enhance immune suppression by facilitating the generation of myeloid-derived suppressor cells.
Author: Deng, Y|Cheng, J|Fu, B|Liu, W|Chen, G|Zhang, Q|Yang, Y
PMID: 27593937
Journal: Oncol Res. 2017 Jan 26;25(2):285-293.
Title: CKLF-Like MARVEL Transmembrane Domain-Containing Member 3 (CMTM3) Inhibits the Proliferation and Tumorigenisis in Hepatocellular Carcinoma Cells.
Author: Li, Wujun|Zhang, Shaobo
PMID: 27629543
Journal: Int J Cancer. 2017 Feb 1;140(3):705-717.
Title: Sorafenib with ASC-J9((R)) synergistically suppresses the HCC progression via altering the pSTAT3-CCL2/Bcl2 signals.
Author: Xu, Junjie|Lin, Hui|Li, Gonghui|Sun, Yin|Shi, Liang|Ma, Wen-Lung|Chen, Jiang|Cai, Xiujun|Chang, Chawnshang
PMID: 27668844
Journal: J Pineal Res. 2017 Jan;62(1).
Title: Melatonin prevents deregulation of the sphingosine kinase/sphingosine 1-phosphate signaling pathway in a mouse model of diethylnitrosamine-induced hepatocellular carcinoma.
Author: Sanchez, Diana I|Gonzalez-Fernandez, Barbara|San-Miguel, Beatriz|de Urbina, Juan Ortiz|Crespo, Irene|Gonzalez-Gallego, Javier|Tunon, Maria J
PMID: 27696512
Journal: Clin Exp Pharmacol Physiol. 2017 Feb;44(2):213-221.
Title: A tumour-promoting role of Th9 cells in hepatocellular carcinoma through CCL20 and STAT3 pathways.
Author: Tan, Hongwu|Wang, Shuyun|Zhao, Ludong
PMID: 27797409
Journal: J Clin Invest. 2017 Jan 3;127(1):137-152.
Title: Hippo signaling interactions with Wnt/beta-catenin and Notch signaling repress liver tumorigenesis.
Author: Kim, Wantae|Khan, Sanjoy Kumar|Gvozdenovic-Jeremic, Jelena|Kim, Youngeun|Dahlman, Jason|Kim, Hanjun|Park, Ogyi|Ishitani, Tohru|Jho, Eek-Hoon|Gao, Bin|Yang, Yingzi
PMID: 27869648
Journal: Oncotarget. 2017 Mar 28;8(13):22145-22165.
Title: Involvement of inflammation and its related microRNAs in hepatocellular carcinoma.
Author: Jin, Ke|Li, Tong|Sanchez-Duffhues, Gonzalo|Zhou, Fangfang|Zhang, Long
PMID: 27888618
Journal: Cancer Lett. 2017 Mar 1;388:1-11.
Title: Blocking preferential glucose uptake sensitizes liver tumor-initiating cells to glucose restriction and sorafenib treatment.
Author: Zhang, Hui-Lu|Wang, Ming-Da|Zhou, Xu|Qin, Chen-Jie|Fu, Gong-Bo|Tang, Liang|Wu, Han|Huang, Shuai|Zhao, Ling-Hao|Zeng, Min|Liu, Jiao|Cao, Dan|Guo, Lin-Na|Wang, Hong-Yang|Yan, He-Xin|Liu, Jie
PMID: 27894955
Journal: Gastroenterology. 2017 Mar;152(4):880-894.e6.
Title: Molecular Classification of Hepatocellular Adenoma Associates With Risk Factors, Bleeding, and Malignant Transformation.
Author: Nault, Jean-Charles|Couchy, Gabrielle|Balabaud, Charles|Morcrette, Guillaume|Caruso, Stefano|Blanc, Jean-Frederic|Bacq, Yannick|Calderaro, Julien|Paradis, Valerie|Ramos, Jeanne|Scoazec, Jean-Yves|Gnemmi, Viviane|Sturm, Nathalie|Guettier, Catherine|Fabre,
PMID: 27939373
Journal: Biochim Biophys Acta Mol Cell Res. 2017 Mar;1864(3):516-526.
Title: Crosstalk between different family members: IL27 recapitulates IFNgamma responses in HCC cells, but is inhibited by IL6-type cytokines.
Author: Rolvering, Catherine|Zimmer, Andreas D|Kozar, Ines|Hermanns, Heike M|Letellier, Elisabeth|Vallar, Laurent|Nazarov, Petr V|Nicot, Nathalie|Ginolhac, Aurelien|Haan, Serge|Behrmann, Iris|Haan, Claude
PMID: 27939431
Journal: Mol Cancer Ther. 2017 Feb;16(2):312-322.
Title: Blocking the CCL2-CCR2 Axis Using CCL2-Neutralizing Antibody Is an Effective Therapy for Hepatocellular Cancer in a Mouse Model.
Author: Teng, Kun-Yu|Han, Jianfeng|Zhang, Xiaoli|Hsu, Shu-Hao|He, Shun|Wani, Nissar A|Barajas, Juan M|Snyder, Linda A|Frankel, Wendy L|Caligiuri, Michael A|Jacob, Samson T|Yu, Jianhua|Ghoshal, Kalpana
PMID: 27980102
Journal: Toxicol Appl Pharmacol. 2017 Jan 15;315:90-101.
Title: Ilexgenin A exerts anti-inflammation and anti-angiogenesis effects through inhibition of STAT3 and PI3K pathways and exhibits synergistic effects with Sorafenib on hepatoma growth.
Author: Yang, Hao|Wang, Juan|Fan, Jin-Hong|Zhang, Ya-Qi|Zhao, Jun-Xian|Dai, Xiao-Jun|Liu, Qi|Shen, Yan-Jun|Liu, Chang|Sun, Wei-Dong|Sun, Yun
PMID: 27986624
Journal: Biochem Biophys Res Commun. 2017 Jan 29;483(1):578-584.
Title: MicroRNA-340 inhibits the proliferation and invasion of hepatocellular carcinoma cells by targeting JAK1.
Author: Yuan, Jianyong|Ji, Hongxiang|Xiao, Feng|Lin, Zhipeng|Zhao, Xijun|Wang, Zhouchong|Zhao, Jun|Lu, Junhua
PMID: 27998770
Journal: Biochem Biophys Res Commun. 2017 Jan 29;483(1):509-515.
Title: Scutellarin suppresses migration and invasion of human hepatocellular carcinoma by inhibiting the STAT3/Girdin/Akt activity.
Author: Ke, Yang|Bao, Tianhao|Wu, Xuesong|Tang, Haoran|Wang, Yan|Ge, Jiayun|Fu, Bimang|Meng, Xu|Chen, Li|Zhang, Cheng|Tan, Yuqi|Chen, Haotian|Guo, Zhitang|Ni, Fan|Lei, Xuefen|Shi, Zhitian|Wei, Dong|Wang, Lin
PMID: 27998773
Journal: Am J Surg. 2017 Apr;213(4):645-651.
Title: Suberoylanilide hydroxamic Acid, a histone deacetylase inhibitor, alters multiple signaling pathways in hepatocellular carcinoma cell lines.
Author: Kunnimalaiyaan, Selvi|Sokolowski, Kevin|Gamblin, T Clark|Kunnimalaiyaan, Muthusamy
PMID: 28007318
Journal: Oncotarget. 2017 Jan 31;8(5):8499-8511.
Title: DJ-1 promotes development of DEN-induced hepatocellular carcinoma and proliferation of liver cancer cells.
Author: Qiu, Bijun|Wang, Junqi|Yu, Yingxue|Zhen, Chao|Gu, Jinyang|Liu, Wenjun|Wen, Yankai|Chen, Lili|Gao, Yueqiu|Xia, Qiang|Kong, Xiaoni
PMID: 28036277
Journal: Int J Oncol. 2017 Mar;50(3):975-983.
Title: miR-345 inhibits tumor metastasis and EMT by targeting IRF1-mediated mTOR/STAT3/AKT pathway in hepatocellular carcinoma.
Author: Yu, Miao|Xue, Huanzhou|Wang, Yadong|Shen, Quan|Jiang, Qingfeng|Zhang, Xiao|Li, Ke|Jia, Meng|Jia, Jiangkun|Xu, Jian|Tian, Yuwei
PMID: 28098858
Journal: Cancer Sci. 2017 Mar;108(3):338-346.
Title: miR-203 inhibits augmented proliferation and metastasis of hepatocellular carcinoma residual in the promoted regenerating liver.
Author: Zheng, Xiao-Bo|Chen, Xiao-Bo|Xu, Liang-Liang|Zhang, Ming|Feng, Lei|Yi, Peng-Sheng|Tang, Jian-Wei|Xu, Ming-Qing
PMID: 28100026
Journal: PLoS One. 2017 Feb 8;12(2):e0171185.
Title: Quantitative liver proteomics identifies FGF19 targets that couple metabolism and proliferation.
Author: Massafra, Vittoria|Milona, Alexandra|Vos, Harmjan R|Burgering, Boudewijn M T|van Mil, Saskia W C
PMID: 28178326
Journal: Oncotarget. 2017 Apr 4;8(14):23507-23516.
Title: C-terminal truncated hepatitis B virus X protein regulates tumorigenicity, self-renewal and drug resistance via STAT3/Nanog signaling pathway.
Author: Ching, Rachel Hiu Ha|Sze, Karen Man Fong|Lau, Eunice Yuen Ting|Chiu, Yung-Tuen|Lee, Joyce Man Fong|Ng, Irene Oi Lin|Lee, Terence Kin Wah
PMID: 28186991
Journal: BMC Complement Altern Med. 2017 Feb 10;17(1):106.
Title: Cryptotanshinone enhances the effect of Arsenic trioxide in treating liver cancer cell by inducing apoptosis through downregulating phosphorylated- STAT3 in vitro and in vivo.
Author: Shen, Li|Zhang, Guangshun|Lou, Zhaohuan|Xu, Guanhua|Zhang, Guangji
PMID: 28187727
Journal: Hum Mol Genet. 2017 May 15;26(10):1890-1899.
Title: Downregulation of pathways implicated in liver inflammation and tumorigenesis of glycogen storage disease type Ia mice receiving gene therapy.
Author: Kim, Goo-Young|Kwon, Joon Hyun|Cho, Jun-Ho|Zhang, Lisa|Mansfield, Brian C|Chou, Janice Y
PMID: 28334808
Journal: Int J Oncol. 2017 May;50(5):1647-1654.
Title: Clinical implication of Frizzled 2 expression and its association with epithelial-to-mesenchymal transition in hepatocellular carcinoma.
Author: Asano, Tomonari|Yamada, Suguru|Fuchs, Bryan C|Takami, Hideki|Hayashi, Masamichi|Sugimoto, Hiroyuki|Fujii, Tsutomu|Tanabe, Kenneth K|Kodera, Yasuhiro
PMID: 28350091
Journal: Eur Rev Med Pharmacol Sci. 2017 Mar;21(6):1248-1253.
Title: Facilitation of liver cancer SMCC7721 cell aging by sirtuin 4 via inhibiting JAK2/STAT3 signal pathway.
Author: Xia, X-H|Xiao, C-J|Shan, H
PMID: 28387906
Journal: Am J Cancer Res. 2017 Mar 1;7(3):433-447. eCollection 2017.
Title: Gpr110 deficiency decelerates carcinogen-induced hepatocarcinogenesis via activation of the IL-6/STAT3 pathway.
Author: Ma, Benting|Zhu, Junjie|Tan, Juan|Mao, Yulei|Tang, Lingyun|Shen, Chunling|Zhang, Hongxing|Kuang, Ying|Fei, Jian|Yang, Xiao|Wang, Zhugang
PMID: 28401002
Journal: Cell Biosci. 2017 Apr 12;7:16.
Title: Hepatitis B virus promotes cancer cell migration by downregulating miR-340-5p expression to induce STAT3 overexpression.
Author: Xiong, Qiushuang|Wu, Shaoshuai|Wang, Jingwen|Zeng, Xianhuang|Chen, Jianwen|Wei, Mingcong|Guan, Haotong|Fan, Chengpeng|Chen, Lang|Guo, Deyin|Sun, Guihong
PMID: 28413603
Journal: Oncotarget. 2017 Mar 21;8(12):19354-19364.
Title: Secreted GRP78 activates EGFR-SRC-STAT3 signaling and confers the resistance to sorafeinib in HCC cells.
Author: Li, Rui|Yanjiao, Gu|Wubin, He|Yue, Wang|Jianhua, Huang|Huachuan, Zheng|Rongjian, Su|Zhidong, Luan
PMID: 28423613
Journal: Med Oncol. 2017 Jun;34(6):101.
Title: The identification of key genes and pathways in hepatocellular carcinoma by bioinformatics analysis of high-throughput data.
Author: Zhang, Chaoyang|Peng, Li|Zhang, Yaqin|Liu, Zhaoyang|Li, Wenling|Chen, Shilian|Li, Guancheng
PMID: 28432618
Journal: Oncotarget. 2017 Apr 18;8(16):27263-27276.
Title: SHP2 is induced by the HBx-NF-kappaB pathway and contributes to fibrosis during human early hepatocellular carcinoma development.
Author: Kang, Hyo Jeong|Chung, Dal-Hee|Sung, Chang Ohk|Yoo, Su Hyun|Yu, Eunsil|Kim, Nayoung|Lee, Sy-Hye|Song, Ji-Young|Kim, Chong Jai|Choi, Jene
PMID: 28460481
Journal: Oncotarget. 2017 Jun 20;8(25):41242-41255.
Title: Radiation improves antitumor effect of immune checkpoint inhibitor in murine hepatocellular carcinoma model.
Author: Kim, Kyoung-Jin|Kim, Ji-Hye|Lee, Seo Jin|Lee, Eun-Jung|Shin, Eui-Cheol|Seong, Jinsil
PMID: 28465485
Journal: Nat Commun. 2017 May 16;8:15433.
Title: Non-cell-autonomous activation of IL-6/STAT3 signaling mediates FGF19-driven hepatocarcinogenesis.
Author: Zhou, Mei|Yang, Hong|Learned, R Marc|Tian, Hui|Ling, Lei
PMID: 28508871
Journal: Mol Cancer Ther. 2017 Aug;16(8):1531-1543.
Title: Notch Inhibitor PF-03084014 Inhibits Hepatocellular Carcinoma Growth and Metastasis via Suppression of Cancer Stemness due to Reduced Activation of Notch1-Stat3.
Author: Wu, Chuan Xing|Xu, Aimin|Zhang, Cathy C|Olson, Peter|Chen, Lin|Lee, Terence K|Cheung, Tan To|Lo, Chung Mau|Wang, Xiao Qi
PMID: 28522590
Journal: Clin Cancer Res. 2017 Sep 15;23(18):5537-5546.
Title: Multifunctional Effects of a Small-Molecule STAT3 Inhibitor on NASH and Hepatocellular Carcinoma in Mice.
Author: Jung, Kwang Hwa|Yoo, Wonbeak|Stevenson, Heather L|Deshpande, Dipti|Shen, Hong|Gagea, Mihai|Yoo, Suk-Young|Wang, Jing|Eckols, T Kris|Bharadwaj, Uddalak|Tweardy, David J|Beretta, Laura
PMID: 28533225
Journal: Int J Mol Sci. 2017 May 19;18(5). pii: ijms18051095.
Title: Isorhynchophylline, a Potent Plant Alkaloid, Induces Apoptotic and Anti-Metastatic Effects in Human Hepatocellular Carcinoma Cells through the Modulation of Diverse Cell Signaling Cascades.
Author: Lee, Hanwool|Baek, Seung Ho|Lee, Jong Hyun|Kim, Chulwon|Ko, Jeong-Hyeon|Lee, Seok-Geun|Chinnathambi, Arunachalam|Alharbi, Sulaiman Ali|Yang, Woong Mo|Um, Jae-Young|Sethi, Gautam|Ahn, Kwang Seok
PMID: 28534824
Journal: Int J Biol Macromol. 2017 Oct;103:1054-1061.
Title: MiR-221 mediates the epithelial-mesenchymal transition of hepatocellular carcinoma by targeting AdipoR1.
Author: Li, Tong|Li, Min|Hu, Shaobo|Cheng, Xiang|Gao, Yang|Jiang, Shuai|Yu, Qihong|Zhang, Chen|Sun, Ping|Xian, Wenjing|Song, Zifang|Zhang, Yong|Zheng, Qichang
PMID: 28539268
Journal: FEBS Lett. 2017 Jul;591(13):1947-1957.
Title: Deletion of HNF1alpha in hepatocytes results in fatty liver-related hepatocellular carcinoma in mice.
Author: Ni, Qi|Ding, Kai|Wang, Ke-Qi|He, Jin|Yin, Chuan|Shi, Jian|Zhang, Xin|Xie, Wei-Fen|Shi, Yong-Quan
PMID: 28547778
Journal: Oncol Rep. 2017 Jul;38(1):393-401.
Title: miR-30e acts as a tumor suppressor in hepatocellular carcinoma partly via JAK1/STAT3 pathway.
Author: Mao, Junjie|Hu, Xiaojun|Pang, Pengfei|Zhou, Bin|Li, Dan|Shan, Hong
PMID: 28560434
Journal: Oncogene. 2017 Oct 12;36(41):5709-5721.
Title: Activation of tumor suppressor LKB1 by honokiol abrogates cancer stem-like phenotype in breast cancer via inhibition of oncogenic Stat3.
Author: Sengupta, S|Nagalingam, A|Muniraj, N|Bonner, M Y|Mistriotis, P|Afthinos, A|Kuppusamy, P|Lanoue, D|Cho, S|Korangath, P|Shriver, M|Begum, A|Merino, V F|Huang, C-Y|Arbiser, J L|Matsui, W|Gyorffy, B|Konstantopoulos, K|Sukumar, S|Marignani, P A|Saxena, N K|Sha
PMID: 28581518
Journal: Oncotarget. 2017 Jun 20;8(25):39978-39993.
Title: Peretinoin, an acyclic retinoid, suppresses steatohepatitis and tumorigenesis by activating autophagy in mice fed an atherogenic high-fat diet.
Author: Okada, Hikari|Takabatake, Riuta|Honda, Masao|Takegoshi, Kai|Yamashita, Taro|Nakamura, Mikiko|Shirasaki, Takayoshi|Sakai, Yoshio|Shimakami, Tetsuro|Nagata, Naoto|Takamura, Toshinari|Tanaka, Takuji|Kaneko, Shuichi
PMID: 28591717
Journal: Int J Mol Med. 2017 Aug;40(2):263-270.
Title: Therapeutic strategies for alcoholic liver disease: Focusing on inflammation and fibrosis (Review).
Author: Kawaratani, Hideto|Moriya, Kei|Namisaki, Tadashi|Uejima, Masakazu|Kitade, Mitsuteru|Takeda, Kousuke|Okura, Yasushi|Kaji, Kousuke|Takaya, Hiroaki|Nishimura, Norihisa|Sato, Shinya|Sawada, Yasuhiko|Seki, Kenichiro|Kubo, Takuya|Mitoro, Akira|Yamao, Junichi|Yo
PMID: 28627645
Journal: Oncol Rep. 2017 Aug;38(2):899-907.
Title: Targeting the PD-L1/DNMT1 axis in acquired resistance to sorafenib in human hepatocellular carcinoma.
Author: Liu, Jianhua|Liu, Yahui|Meng, Lingyu|Liu, Kai|Ji, Bai
PMID: 28627705
Journal: Neoplasia. 2017 Jul;19(7):583-593.
Title: Knockout of the Nogo-B Gene Attenuates Tumor Growth and Metastasis in Hepatocellular Carcinoma.
Author: Zhu, Bo|Chen, Shaobo|Hu, Xiaoding|Jin, Xiaofeng|Le, Yichen|Cao, Lihuan|Yuan, Zhonghua|Lin, Zhen|Jiang, Songmin|Sun, Lichun|Yu, Long
PMID: 28628795
Journal: Int J Biol Macromol. 2017 Nov;104(Pt A):681-686.
Title: A pumpkin polysaccharide induces apoptosis by inhibiting the JAK2/STAT3 pathway in human hepatoma HepG2 cells.
Author: Shen, Weixi|Chen, Chunhong|Guan, Yuanyuan|Song, Xiaowei|Jin, Yinghua|Wang, Jingfang|Hu, Yu|Xin, Tao|Jiang, Qiuying|Zhong, Li
PMID: 28634059
Journal: Biosci Rep. 2017 Jul 21;37(4). pii: BSR20170181.
Title: Secretion of interleukin-6 by bone marrow mesenchymal stem cells promotes metastasis in hepatocellular carcinoma.
Author: Mi, Fei|Gong, Liansheng
PMID: 28659496
Journal: Drug Des Devel Ther. 2017 Jun 16;11:1789-1802.
Title: Morusin shows potent antitumor activity for human hepatocellular carcinoma in vitro and in vivo through apoptosis induction and angiogenesis inhibition.
Author: Gao, Ling|Wang, Li|Sun, Zhen|Li, Haiyan|Wang, Qiaoping|Yi, Cheng|Wang, Xiujie
PMID: 28670112
Journal: Oncol Rep. 2017 Aug;38(2):1224-1232.
Title: Norcantharidin inhibits IL-6-induced epithelialmesenchymal transition via the JAK2/STAT3/TWIST signaling pathway in hepatocellular carcinoma cells.
Author: Gao, Yebo|Li, Weidong|Liu, Rui|Guo, Qiujun|Li, Jie|Bao, Yanju|Zheng, Honggang|Jiang, Shulong|Hua, Baojin
PMID: 28677802
Journal: World J Surg Oncol. 2017 Jul 21;15(1):136.
Title: Long noncoding RNA expression profiles in sub-lethal heat-treated hepatoma carcinoma cells.
Author: Deng, Qingsong|Chen, Shihan|Fu, Chunchuan|Jiang, Jiayun|Zou, Mengda|Tan, Yunhua|Wang, Xiaofei|Xia, Feng|Feng, Kai|Ma, Kuansheng|Bie, Ping
PMID: 28732507
Journal: J Exp Clin Cancer Res. 2017 Jul 27;36(1):99.
Title: miR-500a-3p promotes cancer stem cells properties via STAT3 pathway in human hepatocellular carcinoma.
Author: Jiang, Chunlin|Long, Jianting|Liu, Baoxian|Xu, Ming|Wang, Wei|Xie, Xiaoyan|Wang, Xiaolin|Kuang, Ming
PMID: 28750679
Journal: Am J Pathol. 2017 Nov;187(11):2473-2485.
Title: Thyroid Hormone Receptor-beta Agonist GC-1 Inhibits Met-beta-Catenin-Driven Hepatocellular Cancer.
Author: Puliga, Elisabetta|Min, Qian|Tao, Junyan|Zhang, Rong|Pradhan-Sundd, Tirthadipa|Poddar, Minakshi|Singh, Sucha|Columbano, Amedeo|Yu, Jinming|Monga, Satdarshan P
PMID: 28807594
Journal: Mol Cancer. 2017 Aug 14;16(1):136.
Title: STAT3-mediated upregulation of lncRNA HOXD-AS1 as a ceRNA facilitates liver cancer metastasis by regulating SOX4.
Author: Wang, Hui|Huo, Xisong|Yang, Xin-Rong|He, Jia|Cheng, Lijun|Wang, Na|Deng, Xuan|Jin, Haojie|Wang, Ning|Wang, Cun|Zhao, Fangyu|Fang, Jingyuan|Yao, Ming|Fan, Jia|Qin, Wenxin
PMID: 28810927
Journal: Am J Transl Res. 2017 Aug 15;9(8):3853-3866. eCollection 2017.
Title: The STAT3 inhibitor pimozide impedes cell proliferation and induces ROS generation in human osteosarcoma by suppressing catalase expression.
Author: Cai, Nan|Zhou, Wei|Ye, Lan-Lan|Chen, Jun|Liang, Qiu-Ni|Chang, Gang|Chen, Jia-Jie
PMID: 28861175
Journal: Apoptosis. 2017 Nov;22(11):1404-1418.
Title: 20(S)-25-methoxyl-dammarane-3beta, 12beta, 20-triol negatively regulates activation of STAT3 and ERK pathways and exhibits anti-cancer effects in HepG2 cells.
Author: Ai, Hui-Han|Zhou, Zi-Long|Sun, Lu-Guo|Yang, Mei-Ting|Li, Wei|Yu, Chun-Lei|Song, Zhen-Bo|Huang, Yan-Xin|Wu, Yin|Liu, Lei|Yang, Xiao-Guang|Zhao, Yu-Qing|Bao, Yong-Li|Li, Yu-Xin
PMID: 28864870
Journal: Cell Mol Gastroenterol Hepatol. 2017 Jul 19;4(3):339-363.
Title: Hepatitis B Virus Activates Signal Transducer and Activator of Transcription 3 Supporting Hepatocyte Survival and Virus Replication.
Author: Hosel, Marianna|Quasdorff, Maria|Ringelhan, Marc|Kashkar, Hamid|Debey-Pascher, Svenja|Sprinzl, Martin F|Bockmann, Jan-Hendrik|Arzberger, Silke|Webb, Dennis|von Olshausen, Gesa|Weber, Achim|Schultze, Joachim L|Buning, Hildegard|Heikenwalder, Mathias|Protze
PMID: 28884137
Journal: Int J Oncol. 2017 Oct;51(4):1291-1299.
Title: Synergistic inhibitory effects on hepatocellular carcinoma with recombinant human adenovirus Aspp2 and oxaliplatin via p53-independent pathway in vitro and in vivo.
Author: Liu, Xiaoni|Xu, Jianji|Wang, Shuang|Yu, Xiaoxiao|Kou, Boxin|Chai, Mengyin|Zang, Yunjin|Chen, Dexi
PMID: 28902369
Journal: Cancer Res. 2017 Nov 1;77(21):5831-5845.
Title: ANGPTL1 Interacts with Integrin alpha1beta1 to Suppress HCC Angiogenesis and Metastasis by Inhibiting JAK2/STAT3 Signaling.
Author: Yan, Qian|Jiang, Lingxi|Liu, Ming|Yu, Dandan|Zhang, Yu|Li, Yan|Fang, Shuo|Li, Yan|Zhu, Ying-Hui|Yuan, Yun-Fei|Guan, Xin-Yuan
PMID: 28904065
Journal: PLoS One. 2017 Oct 2;12(10):e0185442.
Title: Gene expression profiling of hepatocarcinogenesis in a mouse model of chronic hepatitis B.
Author: Nosaka, Takuto|Naito, Tatsushi|Hiramatsu, Katsushi|Ohtani, Masahiro|Nemoto, Tomoyuki|Marusawa, Hiroyuki|Ma, Ning|Hiraku, Yusuke|Kawanishi, Shosuke|Yamashita, Taro|Kaneko, Shuichi|Nakamoto, Yasunari
PMID: 28968425
Journal: Sci Rep. 2017 Oct 4;7(1):12651.
Title: Sulforaphane exerts anti-angiogenesis effects against hepatocellular carcinoma through inhibition of STAT3/HIF-1alpha/VEGF signalling.
Author: Liu, Peng|Atkinson, Samuel J|Akbareian, Sophia E|Zhou, Zhigang|Munsterberg, Andrea|Robinson, Stephen D|Bao, Yongping
PMID: 28978924
Journal: Oncotarget. 2017 May 10;8(39):65077-65089.
Title: Targeting SHP-1-STAT3 signaling: A promising therapeutic approach for the treatment of cholangiocarcinoma.
Author: Hu, Ming-Hung|Chen, Li-Ju|Chen, Yen-Lin|Tsai, Ming-Shen|Shiau, Chung-Wai|Chao, Tzu-I|Liu, Chun-Yu|Kao, Jia-Horng|Chen, Kuen-Feng
PMID: 29029413
Journal: Toxicol Appl Pharmacol. 2017 Dec 1;336:31-39.
Title: 6-Hydroxy-3-O-methyl-kaempferol 6-O-glucopyranoside potentiates the anti-proliferative effect of interferon alpha/beta by promoting activation of the JAK/STAT signaling by inhibiting SOCS3 in hepatocellular carcinoma cells.
Author: Wonganan, Orawan|He, Yu-Jiao|Shen, Xiao-Fei|Wongkrajang, Kanjana|Suksamrarn, Apichart|Zhang, Guo-Lin|Wang, Fei
PMID: 29031523
Journal: Drug Des Devel Ther. 2017 Sep 26;11:2841-2850.
Title: Downregulation of A20 increases the cytotoxicity of IFN-gamma in hepatocellular carcinoma cells.
Author: Yin, Lei|Fang, Zheng|Shen, Ning-Jia|Qiu, Ying-He|Li, Ai-Jun|Zhang, Yong-Jie
PMID: 29033545
Journal: Sci Rep. 2017 Oct 25;7(1):14043.
Title: Radiosensitizing effect of ellagic acid on growth of Hepatocellular carcinoma cells: an in vitro study.
Author: Das, Ujjal|Biswas, Sushobhan|Chattopadhyay, Sreya|Chakraborty, Anindita|Dey Sharma, Rakhi|Banerji, Asoke|Dey, Sanjit
PMID: 29070894
Journal: Cell Physiol Biochem. 2017;43(6):2379-2390.
Title: IL-17 Activates the IL-6/STAT3 Signal Pathway in the Proliferation of Hepatitis B Virus-Related Hepatocellular Carcinoma.
Author: Hu, Zongqiang|Luo, Ding|Wang, Dongdong|Ma, Linjie|Zhao, Yingpeng|Li, Li
PMID: 29073625
Journal: World J Gastroenterol. 2017 Sep 28;23(36):6639-6649.
Title: Attenuation of MET-mediated migration and invasion in hepatocellular carcinoma cells by SOCS1.
Author: Gui, Yirui|Khan, Md Gulam Musawwir|Bobbala, Diwakar|Dubois, Claire|Ramanathan, Sheela|Saucier, Caroline|Ilangumaran, Subburaj
PMID: 29085209
Journal: World J Gastroenterol. 2017 Oct 7;23(37):6833-6844.
Title: STAT3 deficiency prevents hepatocarcinogenesis and promotes biliary proliferation in thioacetamide-induced liver injury.
Author: Abe, Mitsuhiko|Yoshida, Takafumi|Akiba, Jun|Ikezono, Yu|Wada, Fumitaka|Masuda, Atsutaka|Sakaue, Takahiko|Tanaka, Toshimitsu|Iwamoto, Hideki|Nakamura, Toru|Sata, Michio|Koga, Hironori|Yoshimura, Akihiko|Torimura, Takuji
PMID: 29085226
Journal: Oncotarget. 2017 Sep 15;8(44):77915-77927.
Title: Effect of TALEN-mediated IL-6 knockout on cell proliferation, apoptosis, invasion and anti-cancer therapy in hepatocellular carcinoma (HCC-LM3) cells.
Author: Zhuang, Peng-Yuan|Zhang, Ke-Wei|Wang, Jian-Dong|Zhou, Xue-Ping|Liu, Ying-Bin|Quan, Zhi-Wei|Shen, Jun
PMID: 29100435
Journal: J Exp Clin Cancer Res. 2017 Nov 7;36(1):156.
Title: STAT3-blocked whole-cell hepatoma vaccine induces cellular and humoral immune response against HCC.
Author: Han, Qiuju|Wang, Yaqun|Pang, Min|Zhang, Jian
PMID: 29115974
Journal: Chin Med J (Engl). 2017 Nov 20;130(22):2686-2690.
Title: Signal Transducer and Activator of Transcription 3 for the Differentiation of Hepatocellular Carcinoma from Cirrhosis.
Author: Li, Yan-Ping|Wang, Wen-Ze|Chen, Xue-Qi|Li, Ling-Bo|Liang, Zhi-Yong|Ru, Kun|Li, Jing-Nan
PMID: 29133756
Journal: J Cancer. 2017 Oct 17;8(18):3707-3717.
Title: Santamarine Inhibits NF-small ka, CyrillicB and STAT3 Activation and Induces Apoptosis in HepG2 Liver Cancer Cells via Oxidative Stress.
Author: Mehmood, Tahir|Maryam, Amara|Tian, Xiangge|Khan, Muhammad|Ma, Tonghui
PMID: 29151958
Journal: Oncotarget. 2017 Oct 25;8(60):102006-102019.
Title: Long non-coding RNA00364 represses hepatocellular carcinoma cell proliferation via modulating p-STAT3-IFIT2 signaling axis.
Author: Tang, Wei-Guo|Hu, Bo|Sun, Hai-Xiang|Sun, Qi-Man|Sun, Chao|Fu, Pei-Yao|Yang, Zhang-Fu|Zhang, Xin|Zhou, Chen-Hao|Fan, Jia|Ren, Ning|Xu, Yang
PMID: 29254221
Journal: Gut. 2018 May;67(5):953-962.
Title: miR-135a-5p-mediated downregulation of protein tyrosine phosphatase receptor delta is a candidate driver of HCV-associated hepatocarcinogenesis.
Author: Van Renne, Nicolaas|Roca Suarez, Armando Andres|Duong, Francois H T|Gondeau, Claire|Calabrese, Diego|Fontaine, Nelly|Ababsa, Amina|Bandiera, Simonetta|Croonenborghs, Tom|Pochet, Nathalie|De Blasi, Vito|Pessaux, Patrick|Piardi, Tullio|Sommacale, Daniele|On
PMID: 28159835
Journal: Cell Mol Immunol. 2018 Mar;15(3):272-281.
Title: Type I IFN augments IL-27-dependent TRIM25 expression to inhibit HBV replication.
Author: Tan, Guangyun|Xiao, Qingfei|Song, Hongxiao|Ma, Feng|Xu, Fengchao|Peng, Di|Li, Na|Wang, Xiaosong|Niu, Junqi|Gao, Pujun|Qin, F Xiao-Feng|Cheng, Genhong
PMID: 28194021
Journal: Appl Biochem Biotechnol. 2018 Jan;184(1):212-227.
Title: Inhibitory Effect and Mechanism of Mesenchymal Stem Cells Cultured in 3D System on Hepatoma Cells HepG2.
Author: Zhao, Diandian|Hou, Lingling|Pan, Mengwu|Hua, Jilei|Wang, Ziling|He, Jinsheng|Hu, Honggang
PMID: 28664526
Journal: Mol Carcinog. 2018 Jan;57(1):44-56.
Title: Metformin incombination with curcumin inhibits the growth, metastasis, and angiogenesis of hepatocellular carcinoma in vitro and in vivo.
Author: Zhang, Hui-Hui|Zhang, Ying|Cheng, Yan-Na|Gong, Fu-Lian|Cao, Zhan-Qi|Yu, Lu-Gang|Guo, Xiu-Li
PMID: 28833603
Journal: Clin Exp Med. 2018 Feb;18(1):79-87.
Title: Detection of promoter methylation status of suppressor of cytokine signaling 3 (SOCS3) in tissue and plasma from Chinese patients with different hepatic diseases.
Author: Wei, Ling|Huang, Yuan|Zhao, Rongce|Zhang, Jing|Liu, Qiuying|Liang, Weibo|Ding, Xueqin|Gao, Bo|Li, Bo|Sun, Chengjun|He, Jingyang|Yu, Xiaoqin|Liu, Zhongjian|Sun, Aimin|Qin, Yang
PMID: 28951980
Journal: Int J Hyperthermia. 2018 Sep;34(6):812-823.
Title: Heat stress induced, ligand-independent MET and EGFR signalling in hepatocellular carcinoma.
Author: Thompson, Scott M|Jondal, Danielle E|Butters, Kim A|Knudsen, Bruce E|Anderson, Jill L|Stokes, Matthew P|Jia, Xiaoying|Grande, Joseph P|Roberts, Lewis R|Callstrom, Matthew R|Woodrum, David A
PMID: 28954551
Journal: Artif Cells Nanomed Biotechnol. 2018 Nov;46(7):1301-1313.
Title: Gankyrin: a novel promising therapeutic target for hepatocellular carcinoma.
Author: Zamani, Parvin|Matbou Riahi, Maryam|Momtazi-Borojeni, Amir Abbas|Jamialahmadi, Khadijeh
PMID: 29025272
Journal: Carcinogenesis. 2018 Jan 12;39(1):28-35.
Title: Eicosapentaenoic acid attenuates obesity-related hepatocellular carcinogenesis.
Author: Inoue-Yamauchi, Akane|Itagaki, Hiroko|Oda, Hideaki
PMID: 29040439
Journal: Asia Pac J Clin Oncol. 2018 Jun;14(3):134-140.
Title: Molecular targets for the therapy of cancer associated with metabolic syndrome (transcription and growth factors).
Author: Yunusova, Natalia V|Kondakova, Irina V|Kolomiets, Larisa A|Afanas'ev, Sergey G|Chernyshova, Alena L|Kudryavtsev, Igor V|Tsydenova, Anastasia A
PMID: 29115033
Journal: Int J Mol Med. 2018 Jan;41(1):129-136.
Title: Transforming growth factor beta1 promotes migration and invasion in HepG2 cells: Epithelialtomesenchymal transition via JAK/STAT3 signaling.
Author: Lin, Xiao-Long|Liu, Mihua|Liu, Yuanbo|Hu, Huijun|Pan, Yongquan|Zou, Weiwen|Fan, Xiaojuan|Hu, Xuemei
PMID: 29115395
Journal: Cancer Res. 2018 Jan 1;78(1):75-87.
Title: Deficiency in Protein Tyrosine Phosphatase PTP1B Shortens Lifespan and Leads to Development of Acute Leukemia.
Author: Le Sommer, Samantha|Morrice, Nicola|Pesaresi, Martina|Thompson, Dawn|Vickers, Mark A|Murray, Graeme I|Mody, Nimesh|Neel, Benjamin G|Bence, Kendra K|Wilson, Heather M|Delibegovic, Mirela
PMID: 29122767
Journal: Neoplasia. 2018 Jan;20(1):57-68.
Title: Stimulation of Interferon-Stimulated Gene 20 by Thyroid Hormone Enhances Angiogenesis in Liver Cancer.
Author: Lin, Syuan-Ling|Wu, Sheng-Ming|Chung, I-Hsiao|Lin, Yang-Hsiang|Chen, Ching-Ying|Chi, Hsiang-Cheng|Lin, Tzu-Kang|Yeh, Chau-Ting|Lin, Kwang-Huei
PMID: 29195126
Journal: Cancer Lett. 2018 Jun 1;423:113-126.
Title: Maintenance of stemness by miR-589-5p in hepatocellular carcinoma cells promotes chemoresistance via STAT3 signaling.
Author: Long, Jianting|Jiang, Chunlin|Liu, Baoxian|Dai, Qiangsheng|Hua, Ruixi|Chen, Cui|Zhang, Bing|Li, Heping
PMID: 29196128
Journal: J Cell Physiol. 2018 Sep;233(9):6733-6741.
Title: The long noncoding RNA NEAT1 contributes to hepatocellular carcinoma development by sponging miR-485 and enhancing the expression of the STAT3.
Author: Zhang, Xu-Nan|Zhou, Jun|Lu, Xiao-Jie
PMID: 29219178
Journal: Oncol Rep. 2018 Mar;39(3):1155-1162.
Title: Overexpression of interleukin-32alpha promotes invasion by modulating VEGF in hepatocellular carcinoma.
Author: Zhao, Wen-Bo|Wang, Quan-Li|Xu, Yan-Tian|Xu, Shi-Feng|Qiu, Yang|Zhu, Feng
PMID: 29286122
Journal: Int J Biochem Cell Biol. 2018 Mar;96:9-19.
Title: Novel 1,4-naphthoquinone derivatives induce apoptosis via ROS-mediated p38/MAPK, Akt and STAT3 signaling in human hepatoma Hep3B cells.
Author: Liu, Chang|Shen, Gui-Nan|Luo, Ying-Hua|Piao, Xian-Ji|Jiang, Xue-Yuan|Meng, Ling-Qi|Wang, Yue|Zhang, Yi|Wang, Jia-Ru|Wang, Hao|Xu, Wan-Ting|Li, Jin-Qian|Liu, Yang|Wu, Yi-Qin|Sun, Hu-Nan|Han, Ying-Hao|Jin, Mei-Hua|Cui, Yu-Dong|Fang, Nan-Zhu|Jin, Cheng-Hao
PMID: 29326072
Journal: Cell Res. 2018 Mar;28(3):359-373.
Title: Diverse modes of clonal evolution in HBV-related hepatocellular carcinoma revealed by single-cell genome sequencing.
Author: Duan, Meng|Hao, Junfeng|Cui, Sijia|Worthley, Daniel L|Zhang, Shu|Wang, Zhichao|Shi, Jieyi|Liu, Longzi|Wang, Xiaoying|Ke, Aiwu|Cao, Ya|Xi, Ruibin|Zhang, Xiaoming|Zhou, Jian|Fan, Jia|Li, Chong|Gao, Qiang
PMID: 29327728
Journal: Immunopharmacol Immunotoxicol. 2018 Apr;40(2):107-116.
Title: Artesunate enhances gammadelta T-cell-mediated antitumor activity through augmenting gammadelta T-cell function and reversing immune escape of HepG2 cells.
Author: Qian, Peng|Zhang, Yong-Wen|Zhou, Zhong-Hai|Liu, Jun-Quan|Yue, Su-Yang|Guo, Xiang-Li|Sun, Lei-Qing|Lv, Xiao-Ting|Chen, Jian-Qun
PMID: 29405080
Journal: Gene Expr. 2018 May 18;18(2):135-147.
Title: The Effect of Selective c-MET Inhibitor on Hepatocellular Carcinoma in the MET-Active, beta-Catenin-Mutated Mouse Model.
Author: Zhan, Na|Michael, Adeola Adebayo|Wu, Kaiyuan|Zeng, Gang|Bell, Aaron|Tao, Junyan|Monga, Satdarshan P
PMID: 29409568
Journal: Oncol Lett. 2018 Mar;15(3):3333-3338.
Title: STAT3 promotes the proliferation and migration of hepatocellular carcinoma cells by regulating AKT2.
Author: Xie, Yi|Li, Jianmin|Zhang, Chao
PMID: 29435076
Journal: Gut. 2018 Aug;67(8):1493-1504.
Title: CPT2 downregulation adapts HCC to lipid-rich environment and promotes carcinogenesis via acylcarnitine accumulation in obesity.
Author: Fujiwara, Naoto|Nakagawa, Hayato|Enooku, Kenichiro|Kudo, Yotaro|Hayata, Yuki|Nakatsuka, Takuma|Tanaka, Yasuo|Tateishi, Ryosuke|Hikiba, Yohko|Misumi, Kento|Tanaka, Mariko|Hayashi, Akimasa|Shibahara, Junji|Fukayama, Masashi|Arita, Junichi|Hasegawa, Kiyoshi|
PMID: 29437870
Journal: Oncogene. 2018 May;37(18):2456-2468.
Title: Tumor cell-intrinsic Tim-3 promotes liver cancer via NF-kappaB/IL-6/STAT3 axis.
Author: Zhang, Hualin|Song, Yang|Yang, Huimin|Liu, Zhiyan|Gao, Lifen|Liang, Xiaohong|Ma, Chunhong
PMID: 29449693
Journal: Biochem Pharmacol. 2018 Apr;150:191-201.
Title: Natural small molecule bigelovin suppresses orthotopic colorectal tumor growth and inhibits colorectal cancer metastasis via IL6/STAT3 pathway.
Author: Li, Mingyue|Yue, Grace Gar-Lee|Song, Li-Hua|Huang, Mao-Bo|Lee, Julia Kin-Ming|Tsui, Stephen Kwok-Wing|Fung, Kwok-Pui|Tan, Ning-Hua|Lau, Clara Bik-San
PMID: 29454618
Journal: Life Sci. 2018 May 15;201:161-172.
Title: Novel fused oxazepino-indoles (FOIs) attenuate liver carcinogenesis via IL-6/JAK2/STAT3 signaling blockade as evidenced through data-based mathematical modeling.
Author: Singh, Ashok K|Bhadauria, Archana Singh|Kumar, Umesh|Raj, Vinit|Maurya, Vimal|Kumar, Dinesh|Maity, Biswanath|Prakash, Anand|De, Arnab|Samanta, Amalesh|Saha, Sudipta
PMID: 29486150
Journal: Am J Cancer Res. 2018 Feb 1;8(2):302-316. eCollection 2018.
Title: Cancer-associated fibroblasts promote stem cell-like properties of hepatocellular carcinoma cells through IL-6/STAT3/Notch signaling.
Author: Xiong, Si|Wang, Ronghua|Chen, Qian|Luo, Jing|Wang, Jinlin|Zhao, Zhenxiong|Li, Yawen|Wang, Yun|Wang, Xiju|Cheng, Bin
PMID: 29511600
Journal: Onco Targets Ther. 2018 Mar 5;11:1203-1214.
Title: Clinicopathological significance and prognostic role of p-STAT3 in patients with hepatocellular carcinoma.
Author: Liang, Chaojie|Xu, Yingchen|Ge, Hua|Li, Guangming|Wu, Jixiang
PMID: 29551899
Journal: Cell Death Dis. 2018 Apr 1;9(4):422.
Title: Cancer-associated fibroblasts induce PDL1+ neutrophils through the IL6-STAT3 pathway that foster immune suppression in hepatocellular carcinoma.
Author: Cheng, Yusheng|Li, Hui|Deng, Yinan|Tai, Yan|Zeng, Kaining|Zhang, Yingcai|Liu, Wei|Zhang, Qi|Yang, Yang
PMID: 29556041
Journal: Biomed Pharmacother. 2018 Jun;102:420-427.
Title: The anti-inflammatory NHE-06 restores antitumor immunity by targeting NF-kappaB/IL-6/STAT3 signaling in hepatocellular carcinoma.
Author: Lu, Xian|Wo, Guanqun|Li, Binghua|Xu, Chun|Wu, Junhua|Jiang, Chunping|Wei, Jiwu
PMID: 29574282
Journal: Nat Commun. 2018 Mar 28;9(1):1241.
Title: Oncofetal gene SALL4 reactivation by hepatitis B virus counteracts miR-200c in PD-L1-induced T cell exhaustion.
Author: Sun, Cheng|Lan, Peixiang|Han, Qiuju|Huang, Mei|Zhang, Zhihong|Xu, Geliang|Song, Jiaxi|Wang, Jinyu|Wei, Haiming|Zhang, Jian|Sun, Rui|Zhang, Cai|Tian, Zhigang
PMID: 29593314
Journal: Eur Rev Med Pharmacol Sci. 2018 Mar;22(6):1653-1657.
Title: Expression of embryonic liver fodrin (ELF) and stem cell markers in CD13 liver cancer stem cells.
Author: Yu, G|Wen, Q
PMID: 29630108
Journal: Oncotarget. 2018 Feb 26;9(21):15635-15649.
Title: Deletion of sphingosine kinase 1 inhibits liver tumorigenesis in diethylnitrosamine-treated mice.
Author: Chen, Jinbiao|Qi, Yanfei|Zhao, Yang|Kaczorowski, Dominik|Couttas, Timothy A|Coleman, Paul R|Don, Anthony S|Bertolino, Patrick|Gamble, Jennifer R|Vadas, Mathew A|Xia, Pu|McCaughan, Geoffrey W
PMID: 29643998
Journal: Sci Rep. 2018 Apr 12;8(1):5932.
Title: Novel Indole-fused benzo-oxazepines (IFBOs) inhibit invasion of hepatocellular carcinoma by targeting IL-6 mediated JAK2/STAT3 oncogenic signals.
Author: Singh, Ashok K|Bhadauria, Archana S|Kumar, Umesh|Raj, Vinit|Rai, Amit|Kumar, Pranesh|Keshari, Amit K|Kumar, Dinesh|Maity, Biswanath|Nath, Sneha|Prakash, Anand|Saha, Sudipta
PMID: 29651140
Journal: J Cell Mol Med. 2018 Jul;22(7):3679-3690.
Title: The SHH/Gli axis regulates CD90-mediated liver cancer stem cell function by activating the IL6/JAK2 pathway.
Author: Zhang, Ketao|Che, Siyao|Pan, Chuzhi|Su, Zheng|Zheng, Shangyou|Yang, Shanglin|Zhang, Huayao|Li, Wenda|Wang, Weidong|Liu, Jianping
PMID: 29722127
Journal: Cancer Med. 2018 Jun;7(6):2629-2640.
Title: FABP4 suppresses proliferation and invasion of hepatocellular carcinoma cells and predicts a poor prognosis for hepatocellular carcinoma.
Author: Zhong, Cheng-Qian|Zhang, Xiu-Ping|Ma, Ning|Zhang, Er-Bin|Li, Jing-Jing|Jiang, Ya-Bo|Gao, Yu-Zhen|Yuan, Yan-Mei|Lan, Shi-Qian|Xie, Dong|Cheng, Shu-Qun
PMID: 29733540
Journal: Int J Mol Sci. 2018 May 7;19(5). pii: ijms19051386.
Title: Polysaccharides Extracted from Rhizoma Pleionis Have Antitumor Properties In Vitro and in an H22 Mouse Hepatoma Ascites Model In Vivo.
Author: Fang, Yukun|Ning, Anhong|Li, Sha|Zhou, Shaozheng|Liu, Lei|Joseph, Thomson Patrick|Zhong, Mintao|Jiao, Jilong|Zhang, Wei|Shi, Yonghui|Zhang, Meishan|Huang, Min
PMID: 29735884
Journal: Am J Cancer Res. 2018 Apr 1;8(4):662-674. eCollection 2018.
Title: miR-337-3p suppresses the proliferation and invasion of hepatocellular carcinoma cells through targeting JAK2.
Author: Zuo, Xue-Liang|Chen, Zhi-Qiang|Wang, Jun-Feng|Wang, Jin-Guo|Liang, Lin-Hu|Cai, Juan
PMID: 29736311
Journal: J Cachexia Sarcopenia Muscle. 2018 Aug;9(4):727-746.
Title: Group I Paks support muscle regeneration and counteract cancer-associated muscle atrophy.
Author: Cerquone Perpetuini, Andrea|Re Cecconi, Andrea David|Chiappa, Michela|Martinelli, Giulia Benedetta|Fuoco, Claudia|Desiderio, Giovanni|Castagnoli, Luisa|Gargioli, Cesare|Piccirillo, Rosanna|Cesareni, Gianni
PMID: 29781585
Journal: Int J Biochem Cell Biol. 2018 Aug;101:19-28.
Title: LncRNA TUG1 interacting with miR-144 contributes to proliferation, migration and tumorigenesis through activating the JAK2/STAT3 pathway in hepatocellular carcinoma.
Author: Lv, Jun|Kong, Yongkui|Gao, Zhiqiang|Liu, Yanmin|Zhu, Pengfei|Yu, Zujiang
PMID: 29791864
Journal: Mol Immunol. 2018 Jul;99:171-181.
Title: TLR2/4 ligand-amplified liver inflammation promotes initiation of autoimmune hepatitis due to sustained IL-6/IL-12/IL-4/IL-25 expression.
Author: Chi, Gang|Feng, Xin-Xia|Ru, Ying-Xia|Xiong, Ting|Gao, Yuan|Wang, Han|Luo, Zhen-Long|Mo, Ran|Guo, Fang|He, Yong-Pei|Zhang, Gui-Mei|Tian, De-An|Feng, Zuo-Hua
PMID: 29793131
Journal: Int J Biol Sci. 2018 Apr 25;14(5):577-585.
Title: Chemical and genetic inhibition of STAT3 sensitizes hepatocellular carcinoma cells to sorafenib induced cell death.
Author: Xie, Linna|Zeng, Yanhua|Dai, Zichan|He, Wensheng|Ke, Huozhao|Lin, Qiaofa|Chen, Yan|Bu, Jingjing|Lin, Dexin|Zheng, Min
PMID: 29805309
Journal: Front Pharmacol. 2018 May 15;9:483.
Title: Essential Oil Derived From Eupatorium adenophorum Spreng. Mediates Anticancer Effect by Inhibiting STAT3 and AKT Activation to Induce Apoptosis in Hepatocellular Carcinoma.
Author: Chen, Hao|Zhou, Bei|Yang, Jie|Ma, Xinhua|Deng, Shihao|Huang, Yun|Wen, Yanzhang|Yuan, Jingquan|Yang, Xinzhou
PMID: 29867489
Journal: Cancer Cell. 2018 Jun 11;33(6):1061-1077.e6.
Title: Liver Cancer Initiation Requires p53 Inhibition by CD44-Enhanced Growth Factor Signaling.
Author: Dhar, Debanjan|Antonucci, Laura|Nakagawa, Hayato|Kim, Ju Youn|Glitzner, Elisabeth|Caruso, Stefano|Shalapour, Shabnam|Yang, Ling|Valasek, Mark A|Lee, Sooyeon|Minnich, Kerstin|Seki, Ekihiro|Tuckermann, Jan|Sibilia, Maria|Zucman-Rossi, Jessica|Karin, Michael
PMID: 29894692
Journal: Molecules. 2018 Jun 19;23(6). pii: molecules23061482.
Title: Compound K Induces Endoplasmic Reticulum Stress and Apoptosis in Human Liver Cancer Cells by Regulating STAT3.
Author: Zhang, Xuan|Zhang, Silin|Sun, Qitong|Jiao, Wenjun|Yan, Yan|Zhang, Xuewu
PMID: 29921768
Journal: J Cell Physiol. 2018 Jun 19.
Title: EGFL7: Master regulator of cancer pathogenesis, angiogenesis and an emerging mediator of bone homeostasis.
Author: Hong, Guoju|Kuek, Vincent|Shi, Jiaxi|Zhou, Lin|Han, Xiaorui|He, Wei|Tickner, Jennifer|Qiu, Heng|Wei, Qiushi|Xu, Jiake
PMID: 29923200
Journal: Transl Oncol. 2018 Aug;11(4):971-978.
Title: Differential Sensitivity of Human Hepatocellular Carcinoma Xenografts to an IGF-II Neutralizing Antibody May Involve Activated STAT3.
Author: Greenall, Sameer A|Donoghue, Jacqueline|Johns, Terrance G|Adams, Timothy E
PMID: 29933129
Journal: Cell Physiol Biochem. 2018;47(4):1643-1654.
Title: PRMT1 Promoted HCC Growth and Metastasis In Vitro and In Vivo via Activating the STAT3 Signalling Pathway.
Author: Zhang, Xiu-Ping|Jiang, Ya-Bo|Zhong, Cheng-Qian|Ma, Ning|Zhang, Er-Bin|Zhang, Fan|Li, Jing-Jing|Deng, Yue-Zhen|Wang, Kang|Xie, Dong|Cheng, Shu-Qun
PMID: 29945155
Journal: Biomed Pharmacother. 2018 Oct;106:68-76.
Title: Fatty acid binding protein 5 promotes tumor angiogenesis and activates the IL6/STAT3/VEGFA pathway in hepatocellular carcinoma.
Author: Pan, Long|Xiao, Heng|Liao, Rui|Chen, Qingsong|Peng, Chong|Zhang, Yuchi|Mu, Tong|Wu, Zhongjun
PMID: 29957468
Journal: J Food Drug Anal. 2018 Jul;26(3):1024-1032.
Title: Mulberry leaf extract inhibit hepatocellular carcinoma cell proliferation via depressing IL-6 and TNF-alpha derived from adipocyte.
Author: Chang, Chun-Hua|Chang, Yu-Tzu|Tseng, Tsui-Hwa|Wang, Chau-Jong
PMID: 29976395
Journal: Integr Cancer Ther. 2018 Jul 1:1534735418785999.
Title: Antitumor Efficacy of Huqizhengxiao (HQZX) Decoction Based on Inhibition of Telomerase Activity in Nude Mice of Hepatocarcinoma Xenograft.
Author: Yu, XiaoXiao|Lin, Xue-Jun|Wang, Shuang|Liu, XiuHong|Li, WeiHua|Kou, Bu-Xin|Chai, MengYin|Chen, DeXi|Liu, XiaoNi|Wang, XiaoJun
PMID: 29978739
Journal: Cancer Lett. 2018 Oct 10;434:22-32.
Title: Tumor necrosis factor-alpha promotes hepatocellular carcinogenesis through the activation of hepatic progenitor cells.
Author: Jing, Yingying|Sun, Kai|Liu, Wenting|Sheng, Dandan|Zhao, Shanmin|Gao, Lu|Wei, Lixin
PMID: 29981431
Journal: J Exp Clin Cancer Res. 2018 Jul 13;37(1):149.
Title: LINC01287/miR-298/STAT3 feedback loop regulates growth and the epithelial-to-mesenchymal transition phenotype in hepatocellular carcinoma cells.
Author: Mo, Yichao|He, Longguang|Lai, Zeru|Wan, Zhiheng|Chen, Qinshou|Pan, Sibo|Li, Liangfu|Li, Dasheng|Huang, Junwei|Xue, Fan|Che, Siyao
PMID: 30001751
Journal: Gastroenterology. 2018 Sep 5. pii: S0016-5085(18)34764-4.
Title: Overexpression of Rac GTPase Activating Protein 1 Contributes to Proliferation of Cancer Cells by Reducing Hippo Signaling to Promote Cytokinesis.
Author: Yang, Xiao-Mei|Cao, Xiao-Yan|He, Ping|Li, Jun|Feng, Ming-Xuan|Zhang, Yan-Li|Zhang, Xue-Li|Wang, Ya-Hui|Yang, Qin|Zhu, Lei|Nie, Hui-Zhen|Jiang, Shu-Heng|Tian, Guang-Ang|Zhang, Xiao-Xin|Liu, Qiang|Ji, Jianguang|Zhu, Xuefeng|Xia, Qiang|Zhang, Zhi-Gang
PMID: 30009820
Journal: Hepatology. 2018 Jul 27.
Title: Schistosoma mansoni egg secreted antigens activate HCC-associated transcription factors c-Jun and STAT3 in hamster and human hepatocytes.
Author: Roderfeld, Martin|Padem, Sevinc|Lichtenberger, Jakob|Quack, Thomas|Weiskirchen, Ralf|Longerich, Thomas|Schramm, Gabriele|Churin, Yuri|Irungbam, Karuna|Tschuschner, Annette|Windhorst, Anita|Grevelding, Christoph G|Roeb, Elke
PMID: 30053321
Journal: Cells. 2018 Aug 8;7(8). pii: cells7080099.
Title: CEP55 Promotes Cell Motility via JAK2(-)STAT3(-)MMPs Cascade in Hepatocellular Carcinoma.
Author: Li, Minjing|Gao, Ju|Li, Defang|Yin, Yancun
PMID: 30096813
Journal: Biomed Pharmacother. 2018 Oct;106:1195-1209.
Title: Antioxidant and apoptotic effects of Callistemon lanceolatus leaves and their compounds against human cancer cells.
Author: Ahmad, Kamal|Hafeez, Zubair Bin|Bhat, Abdul Roof|Rizvi, Moshahid Alam|Thakur, Sonu C|Azam, Amir|Athar, Fareeda
PMID: 30119188
Journal: Front Pharmacol. 2018 Aug 13;9:889.
Title: Cannabidiol (CBD) Is a Novel Inhibitor for Exosome and Microvesicle (EMV) Release in Cancer.
Author: Kosgodage, Uchini S|Mould, Rhys|Henley, Aine B|Nunn, Alistair V|Guy, Geoffrey W|Thomas, E L|Inal, Jameel M|Bell, Jimmy D|Lange, Sigrun
PMID: 30150937
Journal: Nan Fang Yi Ke Da Xue Xue Bao. 2018 Jul 30;38(8):1002-1007.
Title: [10-gingerol inhibits proliferation of hepatocellular carcinoma HepG2 cells via Src/STAT3 signaling pathway].
Author: Chen, Jianxin|Wu, Yifen|Li, Shuji|Wu, Hongyuan|Li, Libo
PMID: 30187878
Journal: Hepatobiliary Pancreat Dis Int. 2018 Aug 29. pii: S1499-3872(18)30190-5.
Title: IL-37b suppresses epithelial mesenchymal transition in hepatocellular carcinoma by inhibiting IL-6/STAT3 signaling.
Author: Pu, Xing-Yu|Zheng, Dao-Feng|Shen, Ai|Gu, Hai-Tao|Wei, Xu-Fu|Mou, Tong|Zhang, Jian-Bo|Liu, Rui
PMID: 30201411
Journal: Lab Invest. 2018 Sep 11. pii: 10.1038/s41374-018-0127-3.
Title: The STAT3 inhibitor S3I-201 suppresses fibrogenesis and angiogenesis in liver fibrosis.
Author: Wang, Zhuo|Li, Jia'an|Xiao, Wen'ang|Long, Jiafu|Zhang, Hongmin
PMID: 30206312
Journal: Biomed Pharmacother. 2018 Sep 11;108:65-75.
Title: Chemopreventive and antitumor effects of benzyl isothiocynate on HCC models: A possible role of HGF /pAkt/ STAT3 axis and VEGF.
Author: Zakaria, Sherin|Helmy, Maged Wasfy|Salahuddin, Ahmed|Omran, Gamal
PMID: 30216802
Journal: Gene Expr. 2018 Sep 18.
Title: PRMT1-dependent macrophage IL6 production is required for alcohol-induced HCC progression.
Author: Zhao, Jie|O'Neil, Maura|Vittal, Anusha|Weinman, Steven A|Tikhanovich, Irina
PMID: 30236171
Journal: Pathol Res Pract. 2018 Aug 8. pii: S0344-0338(18)30139-0.
Title: MiR-137 suppresses migration and invasion by targeting EZH2-STAT3 signaling in human hepatocellular carcinoma.
Author: Huang, Bin|Huang, Manping|Li, Qin
PMID: 30274685
Journal: Cancer Biol Ther. 2018 Oct 2:1-8.
Title: Sorafenib inhibits caspase-1 expression through suppressing TLR4/stat3/SUMO1 pathway in hepatocellular carcinoma.
Author: Li, Jun|Zhou, Yuan|Liu, Yang|Dai, Bo|Zhang, Yu-Hen|Zhang, Peng-Fei|Shi, Xiao-Lei
PMID: 30277836
Journal: J Cell Physiol. 2018 Oct 14.
Title: LINC01433 promotes hepatocellular carcinoma progression via modulating the miR-1301/STAT3 axis.
Author: Huang, Haijin|Bu, Yan-Zhi|Zhang, Xiao-Yu|Liu, Juan|Zhu, Li-Yao|Fang, Yong
PMID: 30317567
Journal: Cell Death Dis. 2018 Oct 30;9(11):1105.
Title: Endoplasmic reticulum resident oxidase ERO1-Lalpha promotes hepatocellular carcinoma metastasis and angiogenesis through the S1PR1/STAT3/VEGF-A pathway.
Author: Yang, Shikun|Yang, Chao|Yu, Fei|Ding, Wenbing|Hu, Yuanchang|Cheng, Feng|Zhang, Feng|Guan, Bugao|Wang, Xuehao|Lu, Ling|Rao, Jianhua
PMID: 30377291
Journal: Oncoimmunology. 2018 Aug 6;7(11):e1503913.
Title: NEAT1 paraspeckle promotes human hepatocellular carcinoma progression by strengthening IL-6/STAT3 signaling.
Author: Wang, Shuai|Zhang, Qian|Wang, Qinlan|Shen, Qicong|Chen, Xiang|Li, Zhenyang|Zhou, Ye|Hou, Jin|Xu, Bowen|Li, Nan|Cao, Xuetao
PMID: 30377567
Journal: Clin Res Hepatol Gastroenterol. 2018 Oct 29. pii: S2210-7401(18)30215-8.
Title: Expression and prognostic value of HER-2/neu, STAT3 and SOCS3 in hepatocellular carcinoma.
Author: Jiang, Li-Hua|Hao, Ying-Li|Zhu, Jing-Wei
PMID: 30385249