Primary Site >> Liver Cancer
Gene >> STAT3
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Ref: Complex of the soluble IL-11 receptor and IL-11 acts as IL-6-type cytokine in hepatic and nonhepatic cells. PMID: 8683127 |
Ref: HBx protein of hepatitis B virus activates Jak1-STAT signaling. PMID: 9738022 |
Ref: Contributions of leukemia inhibitory factor receptor and oncostatin M receptor to signal transduction in heterodimeric complexes with glycoprotein 130. PMID: 10586060 |
Ref: [Effects of Stat3 phosphorylation and expression of c-fos and c-jun proteins on hepatocarcinogenesis]. PMID: 12536605 |
Ref: Activation of STAT3 by the hepatitis C virus core protein leads to cellular transformation. PMID: 12208879 |
Ref: Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2. PMID: 12552091 Ref: A common set of immediate-early response genes in liver regeneration and hyperplasia. PMID: 12883475 Ref: Expression of hepatitis C virus non-structural 5A protein in the liver of transgenic mice. PMID: 14675768 |
Ref: Effects of acyclic retinoid on growth, cell cycle control, epidermal growth factor receptor signaling, and gene expression in human squamous cell carcinoma cells. PMID: 14871993 Ref: Hepatitis C virus NS5A mediated STAT3 activation requires co-operation of Jak1 kinase. PMID: 15063116 Ref: Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation. PMID: 15122762 Ref: Constitutional activation of IL-6-mediated JAK/STAT pathway through hypermethylation of SOCS-1 in human gastric cancer cell line. PMID: 15354212 |
Ref: Des-gamma-carboxy prothrombin is a potential autologous growth factor for hepatocellular carcinoma. PMID: 15582995 Ref: Interleukin-6 inhibits cell proliferation in a rat model of hepatocellular carcinoma. PMID: 15780071 Ref: Methylation silencing of SOCS-3 promotes cell growth and migration by enhancing JAK/STAT and FAK signalings in human hepatocellular carcinoma. PMID: 16007195 Ref: Epidermal growth factor receptor: a novel target of the Wnt/beta-catenin pathway in liver. PMID: 16012954 Ref: STAT3 NH2-terminal acetylation is activated by the hepatic acute-phase response and required for IL-6 induction of angiotensinogen. PMID: 16285960 |
Ref: Loss of SOCS3 in the liver promotes fibrosis by enhancing STAT3-mediated TGF-beta1 production. PMID: 16474852 Ref: [Effects of STAT3 antisense oligodeoxynucleotides on apoptosis and proliferation of mouse melanoma cell line B16]. PMID: 16536977 Ref: Microarray analyses and molecular profiling of Stat3 signaling pathway induced by hepatitis C virus core protein in human hepatocytes. PMID: 16545852 Ref: Functional expression of a biologically active fragment of soluble gp130 as an ELP-fusion protein in transgenic plants: purification via inverse transition cycling. PMID: 16716147 Ref: Biliary wound healing, ductular reactions, and IL-6/gp130 signaling in the development of liver disease. PMID: 16773708 Ref: Deletion of the SOCS3 gene in liver parenchymal cells promotes hepatitis-induced hepatocarcinogenesis. PMID: 16831601 Ref: [Relationship of hypoxia-induced factor with tumor angiogenesis in early liver metastasis in colonic cancer]. PMID: 16886122 Ref: HCV core expression in hepatocytes protects against autoimmune liver injury and promotes liver regeneration in mice. PMID: 17006910 Ref: The interaction of hepatitis B virus X protein and protein phosphatase type 2 Calpha and its effect on IL-6. PMID: 17055456 Ref: Microencapsulation of engineered cells to deliver sustained high circulating levels of interleukin-6 to study hepatocellular carcinoma progression. PMID: 17269449 |
Ref: Altered p-STAT3 (tyr705) expression is associated with histological grading and intratumour microvessel density in hepatocellular carcinoma. PMID: 16901975 Ref: Expression of SOCS1 and SOCS3 genes is differentially regulated in breast cancer cells in response to proinflammatory cytokine and growth factor signals. PMID: 17001312 Ref: Roles of EGFR-Stat3 signal pathway in carcinogenesis of experimental hepatoma in rats. PMID: 17031671 Ref: TIMP-1 mediates the inhibitory effect of interleukin-6 on the proliferation of a hepatocarcinoma cell line in a STAT3-dependent manner. PMID: 17464423 Ref: Inhibition of Stat3 activity by YC-1 enhances chemo-sensitivity in hepatocellular carcinoma. PMID: 18059167 |
Ref: Interleukin-6 mediates G(0)/G(1) growth arrest in hepatocellular carcinoma through a STAT 3-dependent pathway. PMID: 17574577 Ref: Stat3 up-regulates expression of nicotinamide N-methyltransferase in human cancer cells. PMID: 17922140 Ref: Progenitor/stem cells give rise to liver cancer due to aberrant TGF-beta and IL-6 signaling. PMID: 18263735 Ref: Dual inhibition of Raf and VEGFR2 reduces growth and vascularization of hepatocellular carcinoma in an experimental model. PMID: 18297306 Ref: Synergistic growth inhibition by 9-cis-retinoic acid plus trastuzumab in human hepatocellular carcinoma cells. PMID: 18451248 Ref: Angiotensin II and epidermal growth factor receptor cross-talk mediated by a disintegrin and metalloprotease accelerates tumor cell proliferation of hepatocellular carcinoma cell lines. PMID: 18452483 Ref: ENMD-1198, a novel tubulin-binding agent reduces HIF-1alpha and STAT3 activity in human hepatocellular carcinoma(HCC) cells, and inhibits growth and vascularization in vivo. PMID: 18651980 Ref: Hepatitis C virus core protein augments androgen receptor-mediated signaling. PMID: 18768969 Ref: Epigenetic downregulation of the suppressor of cytokine signaling 1 (Socs1) gene is associated with the STAT3 activation and development of hepatocellular carcinoma induced by methyl-deficiency in rats. PMID: 18843197 Ref: Subcellular mislocalization of mutant hepatitis B X proteins contributes to modulation of STAT/SOCS signaling in hepatocellular carcinoma. PMID: 19321929 Ref: Liver stem cells and tgf-Beta in hepatic carcinogenesis. PMID: 19343145 Ref: Cytoplasmic trapping of CXCR4 in hepatocellular carcinoma cell lines. PMID: 19688049 |
Ref: Targeted constitutive activation of signal transducer and activator of transcription 3 in human hepatocellular carcinoma cells by cucurbitacin B. PMID: 18521604 Ref: ILEI requires oncogenic Ras for the epithelial to mesenchymal transition of hepatocytes and liver carcinoma progression. PMID: 19015638 Ref: Inflammation and liver cancer: new molecular links . PMID: 19250206 Ref: Specific expression and regulation of hepassocin in the liver and down-regulation of the correlation of HNF1alpha with decreased levels of hepassocin in human hepatocellular carcinoma. PMID: 19304666 Ref: Loss of STAT5 causes liver fibrosis and cancer development through increased TGF-{beta} and STAT3 activation. PMID: 19332876 Ref: Identifying apoptosis-evasion proteins/pathways in human hepatoma cells via induction of cellular hormesis by UV irradiation. PMID: 19545154 Ref: Non-structural 5A protein of hepatitis C virus induces a range of liver pathology in transgenic mice. PMID: 19621337 Ref: Cancer stem cells and hepatocellular carcinoma. PMID: 19901516 |
Ref: High expression levels of IKKalpha and IKKbeta are necessary for the malignant properties of liver cancer. PMID: 19728335 Ref: Dangerous liaisons: STAT3 and NF-kappaB collaboration and crosstalk in cancer. PMID: 20018552 Ref: GH modulates hepatic epidermal growth factor signaling in the mouse. PMID: 20032199 Ref: Diosgenin, a steroidal saponin, inhibits STAT3 signaling pathway leading to suppression of proliferation and chemosensitization of human hepatocellular carcinoma cells. PMID: 20053498 Ref: Survivin overexpression in HCC and liver cirrhosis differentially correlates with p-STAT3 and E-cadherin. PMID: 20054802 Ref: Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression. PMID: 20141834 Ref: Cucurbitacin B induces apoptosis and S phase cell cycle arrest in BEL-7402 human hepatocellular carcinoma cells and is effective via oral administration. PMID: 20153103 Ref: Antitumor activity of the aqueous extract from Sedum sarmentosum Bunge in vitro. PMID: 20187800 Ref: Hepatocyte IKKbeta/NF-kappaB inhibits tumor promotion and progression by preventing oxidative stress-driven STAT3 activation. PMID: 20227042 Ref: Tolerance and outcome of patients with unresectable hepatocellular carcinoma treated with sorafenib. PMID: 20300004 Ref: Hepatitis B virus X protein impairs hepatic insulin signaling through degradation of IRS1 and induction of SOCS3. PMID: 20351777 Ref: Expression of Oct4 in HCC and modulation to wnt/beta-catenin and TGF-beta signal pathways. PMID: 20549546 Ref: Inhibition of STAT3 signaling blocks the anti-apoptotic activity of IL-6 in human liver cancer cells. PMID: 20562100 Ref: Suppression of cell death by the secretory form of N-terminal ERC/mesothelin. PMID: 20596597 Ref: Role of IL-6 activated STAT3 and TNF expression in obesity-associated hepatocellular carcinoma. PMID: 20636625 Ref: c-Jun mediates hepatitis C virus hepatocarcinogenesis through signal transducer and activator of transcription 3 and nitric oxide-dependent impairment of oxidative DNA repair. PMID: 20683948 Ref: Leptin as a critical regulator of hepatocellular carcinoma development through modulation of human telomerase reverse transcriptase. PMID: 20723213 Ref: beta-catenin siRNA regulation of apoptosis- and angiogenesis-related gene expression in hepatocellular carcinoma cells: potential uses for gene therapy. PMID: 20811694 Ref: Sorafenib overcomes TRAIL resistance of hepatocellular carcinoma cells through the inhibition of STAT3. PMID: 20884624 Ref: Ad.mda-7 (IL-24) selectively induces apoptosis in hepatocellular carcinoma cell lines, suppresses metastasis, and enhances the effect of doxorubicin on xenograft tumors. PMID: 20939432 Ref: Adiponectin antagonizes the oncogenic actions of leptin in hepatocellular carcinogenesis. PMID: 20941777 Ref: [The role and significance of Wnt/beta-catenin signaling pathway regulating the signaling molecules in hepatocellular carcinoma]. PMID: 20943078 |
Ref: Suppression of signal transducer and activator of transcription 3 activation by butein inhibits growth of human hepatocellular carcinoma in vivo. PMID: 21131551 Ref: NF-kappaB and STAT3 - key players in liver inflammation and cancer. PMID: 21187858 Ref: Silencing STAT3 may inhibit cell growth through regulating signaling pathway, telomerase, cell cycle, apoptosis and angiogenesis in hepatocellular carcinoma: potential uses for gene therapy. PMID: 21275467 Ref: Extracellular hepatitis C virus core protein activates STAT3 in human monocytes/macrophages/dendritic cells via an IL-6 autocrine pathway. PMID: 21282107 Ref: Blocking the IL-6-STAT3 signaling pathway: potential liver cancer therapy. PMID: 21345134 Ref: Preventive effects of (-)-epigallocatechin gallate on diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/KsJ-db/db Mice. PMID: 21372039 Ref: Regulation of cancer cell proliferation by caveolin-2 down-regulation and re-expression. PMID: 21373752 Ref: Parthenolide sensitizes hepatocellular carcinoma cells to TRAIL by inducing the expression of death receptors through inhibition of STAT3 activation. PMID: 21413021 Ref: Leptin inhibits hepatocellular carcinoma proliferation via p38-MAPK-dependent signalling. PMID: 21418127 Ref: Celecoxib inhibits interleukin-6/interleukin-6 receptor-induced JAK2/STAT3 phosphorylation in human hepatocellular carcinoma cells. PMID: 21490132 Ref: Pleiotropic regulation of macrophage polarization and tumorigenesis by formyl peptide receptor-2. PMID: 21499310 Ref: Ptpn11/Shp2 acts as a tumor suppressor in hepatocellular carcinogenesis. PMID: 21575863 Ref: JAK-STAT signaling in hepatic fibrosis. PMID: 21622209 Ref: STAT3 and beta-catenin signaling pathway may affect GSK-3beta expression in hepatocellular carcinoma. PMID: 21661417 Ref: Interleukin-22 promotes human hepatocellular carcinoma by activation of STAT3. PMID: 21674558 Ref: Hepatoprotective versus oncogenic functions of STAT3 in liver tumorigenesis. PMID: 21684247 Ref: Targeting STAT3 in hepatocellular carcinoma: sorafenib again.... PMID: 21718664 Ref: Impairment of hepatic growth hormone and glucocorticoid receptor signaling causes steatosis and hepatocellular carcinoma in mice. PMID: 21725989 Ref: CD24(+) liver tumor-initiating cells drive self-renewal and tumor initiation through STAT3-mediated NANOG regulation. PMID: 21726833 Ref: Context-Specific Growth Hormone Signaling through the Transcription Factor STAT5: Implications for the Etiology of Hepatosteatosis and Hepatocellular Carcinoma. PMID: 21779476 Ref: Cancer targeting gene-viro-therapy specific for liver cancer by alpha-fetoprotein-controlled oncolytic adenovirus expression of SOCS3 and IL-24. PMID: 21835849 Ref: Roles for rat hepatocyte malignant transforming factor (HMTF) in late stage of hepatocarcinogenesis. PMID: 21934139 Ref: Clinicopathological and prognostic significance of serum and tissue Dickkopf-1 levels in human hepatocellular carcinoma. PMID: 21955977 Ref: An HNF4alpha-miRNA inflammatory feedback circuit regulates hepatocellular oncogenesis. PMID: 22153071 Ref: IL-17 induces AKT-dependent IL-6/JAK2/STAT3 activation and tumor progression in hepatocellular carcinoma. PMID: 22171994 Ref: Targeting liver cancer: first steps toward a miRacle? PMID: 22172719 Ref: Prognostic significance of phosphorylated signal transducer and activator of transcription 3 and suppressor of cytokine signaling 3 expression in hepatocellular carcinoma. PMID: 22977555 |
Ref: Upregulation of B7-H1 expression is associated with macrophage infiltration in hepatocellular carcinomas. PMID: 21853301 Ref: Regression of established hepatocellular carcinoma is induced by chemoimmunotherapy in an orthotopic murine model. PMID: 21898502 Ref: Hepatitis B virus X (HBx) induces tumorigenicity of hepatic progenitor cells in 3,5-diethoxycarbonyl-1,4-dihydrocollidine-treated HBx transgenic mice. PMID: 21932402 Ref: Growth-hormone-induced signal transducer and activator of transcription 5 signaling causes gigantism, inflammation, and premature death but protects mice from aggressive liver cancer. PMID: 22031092 Ref: NSC 74859-mediated inhibition of STAT3 enhances the anti-proliferative activity of cetuximab in hepatocellular carcinoma. PMID: 22098470 Ref: Dovitinib induces apoptosis and overcomes sorafenib resistance in hepatocellular carcinoma through SHP-1-mediated inhibition of STAT3. PMID: 22180308 Ref: Sh(i)pping signals protect against Stat3-driven liver cancer. PMID: 22190379 Ref: Pseudolaric acid B inhibits inducible cyclooxygenase-2 expression via downregulation of the NF-kappaB pathway in HT-29 cells. PMID: 22314698 Ref: Stat3-mediated activation of microRNA-23a suppresses gluconeogenesis in hepatocellular carcinoma by down-regulating glucose-6-phosphatase and peroxisome proliferator-activated receptor gamma, coactivator 1 alpha. PMID: 22318941 Ref: Celastrol suppresses growth and induces apoptosis of human hepatocellular carcinoma through the modulation of STAT3/JAK2 signaling cascade in vitro and in vivo. PMID: 22369852 Ref: Heterodimerization of glycosylated insulin-like growth factor-1 receptors and insulin receptors in cancer cells sensitive to anti-IGF1R antibody. PMID: 22438913 Ref: Downregulation of GRIM-19 is associated with hyperactivation of p-STAT3 in hepatocellular carcinoma. PMID: 22492280 Ref: Constitutively active mutant gp130 receptor protein from inflammatory hepatocellular adenoma is inhibited by an anti-gp130 antibody that specifically neutralizes interleukin 11 signaling. PMID: 22523320 Ref: Impact of coculture with ischemic preconditioned hepatocellular carcinoma cell line (Hep-G2) cells on insulin secreting function of rat insulin-secreting cell line (RIN-5F) cells. PMID: 22564635 Ref: Interferon-alpha enhances antitumor activities of oncolytic adenovirus-mediated IL-24 expression in hepatocellular carcinoma. PMID: 22569271 Ref: [Association of genetic polymorphisms of key molecules in JAK/STAT signaling pathway with susceptibility of hepatocellular carcinoma]. PMID: 22575147 Ref: Synergistic growth inhibition of human hepatocellular carcinoma cells by acyclic retinoid and GW4064, a farnesoid X receptor ligand. PMID: 22579649 Ref: Angiotensin II induces angiogenic factors production partly via AT1/JAK2/STAT3/SOCS3 signaling pathway in MHCC97H cells. PMID: 22613986 Ref: The liver-specific tumor suppressor STAT5 controls expression of the reactive oxygen species-generating enzyme NOX4 and the proapoptotic proteins PUMA and BIM in mice. PMID: 22711600 Ref: Molecular mechanism inhibiting human hepatocarcinoma cell invasion by 6-shogaol and 6-gingerol. PMID: 22714996 Ref: Deletion of IFNgamma enhances hepatocarcinogenesis in FXR knockout mice. PMID: 22728874 Ref: Clinical implications of cancer stem cell biology in hepatocellular carcinoma. PMID: 22846863 Ref: Comparison of the regulation of beta-catenin signaling by type I, type II and type III interferons in hepatocellular carcinoma cells. PMID: 23056571 Ref: Iron regulator hepcidin exhibits antiviral activity against hepatitis C virus. PMID: 23110054 Ref: In vivo induction of apoptosis by fucoxanthin, a marine carotenoid, associated with down-regulating STAT3/EGFR signaling in sarcoma 180 (S180) xenografts-bearing mice. PMID: 23118721 Ref: Interleukin-6 and oncostatin M are elevated in liver disease in conjunction with candidate hepatocellular carcinoma biomarker GP73. PMID: 23144154 Ref: High levels of beta-catenin promote IFNgamma-induced apoptosis in hepatocellular carcinoma cells. PMID: 23162658 Ref: After insufficient radiofrequency ablation, tumor-associated endothelial cells exhibit enhanced angiogenesis and promote invasiveness of residual hepatocellular carcinoma. PMID: 23171368 |
Ref: Suppression of AMF/PGI-mediated tumorigenic activities by ursolic acid in cultured hepatoma cells and in a mouse model. PMID: 22549898 Ref: Interferon regulatory factor (IRF)-1 and IRF-2 are associated with prognosis and tumor invasion in HCC. PMID: 22805863 Ref: Estrogen-sensitive PTPRO expression represses hepatocellular carcinoma progression by control of STAT3. PMID: 22821478 Ref: Evodiamine inhibits STAT3 signaling by inducing phosphatase shatterproof 1 in hepatocellular carcinoma cells. PMID: 23032719 Ref: Molecular characterization of hepatocellular adenomas developed in patients with glycogen storage disease type I. PMID: 23046672 Ref: Epigenetic deregulation of microRNAs: new opportunities to target oncogenic signaling pathways in hepatocellular carcinoma. PMID: 23092339 Ref: Potential role of signal transducer and activator of transcription (STAT)3 signaling pathway in inflammation, survival, proliferation and invasion of hepatocellular carcinoma. PMID: 23103770 Ref: HBx-dependent activation of Twist mediates STAT3 control of epithelium-mesenchymal transition of liver cells. PMID: 23161342 Ref: Scutellarin-induced apoptosis in HepG2 hepatocellular carcinoma cells via a STAT3 pathway. PMID: 23192830 Ref: ANT2 suppression by shRNA may be able to exert anticancer effects in HCC further by restoring SOCS1 expression. PMID: 23242177 Ref: Integrative molecular analysis of intrahepatic cholangiocarcinoma reveals 2 classes that have different outcomes. PMID: 23295441 Ref: Mcl-1-dependent activation of Beclin 1 mediates autophagic cell death induced by sorafenib and SC-59 in hepatocellular carcinoma cells. PMID: 23392173 Ref: Molecular classification of hepatocellular adenomas. PMID: 23401783 Ref: GSTP1 negatively regulates Stat3 activation in epidermal growth factor signaling. PMID: 23426146 Ref: Negative correlation of LIV-1 and E-cadherin expression in hepatocellular carcinoma cells. PMID: 23437163 Ref: Sorafenib enhances radiation-induced apoptosis in hepatocellular carcinoma by inhibiting STAT3. PMID: 23474115 Ref: NF-kappaB and STAT3 signaling pathways collaboratively link inflammation to cancer. PMID: 23483479 Ref: Signal regulatory protein alpha is associated with tumor-polarized macrophages phenotype switch and plays a pivotal role in tumor progression. PMID: 23504854 Ref: HCMV activates the IL-6-JAK-STAT3 axis in HepG2 cells and primary human hepatocytes. PMID: 23555719 Ref: Acetylcholine acts on androgen receptor to promote the migration and invasion but inhibit the apoptosis of human hepatocarcinoma. PMID: 23620780 Ref: Aspirin enhances IFN-alpha-induced growth inhibition and apoptosis of hepatocellular carcinoma via JAK1/STAT1 pathway. PMID: 23703473 Ref: Molecular mechanisms of action and potential biomarkers of growth inhibition of dasatinib (BMS-354825) on hepatocellular carcinoma cells. PMID: 23721490 Ref: Inhibition of VEGF expression through blockade of Hif1alpha and STAT3 signalling mediates the anti-angiogenic effect of melatonin in HepG2 liver cancer cells. PMID: 23756865 Ref: Germacrone induces apoptosis in human hepatoma HepG2 cells through inhibition of the JAK2/STAT3 signalling pathway. PMID: 23771657 Ref: Small heterodimer partner overexpression partially protects against liver tumor development in farnesoid X receptor knockout mice. PMID: 23811326 Ref: Emodin inhibits growth and induces apoptosis in an orthotopic hepatocellular carcinoma model by blocking activation of STAT3. PMID: 23848338 Ref: Alcoholic liver disease: pathogenesis, management, and novel targets for therapy. PMID: 23855300 Ref: Schedule-dependent antitumor effects of 5-fluorouracil combined with sorafenib in hepatocellular carcinoma. PMID: 23895220 Ref: Targeted abrogation of diverse signal transduction cascades by emodin for the treatment of inflammatory disorders and cancer. PMID: 23962559 Ref: Resveratrol suppresses the STAT3 signaling pathway and inhibits proliferation of high glucose-exposed HepG2 cells partly through SIRT1. PMID: 24064760 Ref: Lycopene metabolite, apo-10'-lycopenoic acid, inhibits diethylnitrosamine-initiated, high fat diet-promoted hepatic inflammation and tumorigenesis in mice. PMID: 24085778 Ref: LBH589 Inhibits proliferation and metastasis of hepatocellular carcinoma via inhibition of gankyrin/STAT3/Akt pathway. PMID: 24093956 Ref: Targeting blockage of STAT3 in hepatocellular carcinoma cells augments NK cell functions via reverse hepatocellular carcinoma-induced immune suppression. PMID: 24107450 Ref: Altered methylation and expression of ER-associated degradation factors in long-term alcohol and constitutive ER stress-induced murine hepatic tumors. PMID: 24198826 Ref: [Anti-proliferation effect of sorafenib in combination with 5-FU for hepatocellular carcinoma in vitro: antagonistic performance and mechanism]. PMID: 24331695 Ref: EGFRvIII mediates hepatocellular carcinoma cell invasion by promoting S100 calcium binding protein A11 expression. PMID: 24376686 Ref: From cirrhosis to hepatocellular carcinoma: new molecular insights on inflammation and cellular senescence. PMID: 24400224 |
Ref: Serine 727 phosphorylation of STAT3: an early change in mouse hepatocarcinogenesis induced by neonatal treatment with diethylnitrosamine. PMID: 22911886 Ref: Novel RNA oligonucleotide improves liver function and inhibits liver carcinogenesis in vivo. PMID: 23929703 Ref: Leptin receptor somatic mutations are frequent in HCV-infected cirrhotic liver and associated with hepatocellular carcinoma. PMID: 24055508 Ref: Increased adiponectin associated with poor survival in hepatocellular carcinoma. PMID: 24132578 Ref: Twist2 promotes self-renewal of liver cancer stem-like cells by regulating CD24. PMID: 24193512 Ref: SC-60, a dimer-based sorafenib derivative, shows a better anti-hepatocellular carcinoma effect than sorafenib in a preclinical hepatocellular carcinoma model. PMID: 24275147 Ref: Low hepcidin triggers hepatic iron accumulation in patients with hepatitis C. PMID: 24286977 Ref: Multi-kinase inhibition in ovarian cancer. PMID: 24309512 Ref: Cucurbitacin B and cucurbitacin I suppress adipocyte differentiation through inhibition of STAT3 signaling. PMID: 24316209 Ref: Knockdown of astrocyte elevated gene-1 inhibits growth through suppression of IL-6 secretion in HepG2 human hepatoma cells. PMID: 24348829 Ref: Hepatitis C virus core protein regulates NANOG expression via the stat3 pathway. PMID: 24462277 Ref: Loss of suppressors of cytokine signaling 3 promotes aggressiveness in hepatocellular carcinoma. PMID: 24476004 Ref: Synergistic interaction between the HDAC inhibitor, MPT0E028, and sorafenib in liver cancer cells in vitro and in vivo. PMID: 24520095 Ref: Serine threonine kinase Pim-3 regulates STAT3 pathway to inhibit proliferation of human liver cancers. PMID: 24600488 Ref: MicroRNA-363-mediated downregulation of S1PR1 suppresses the proliferation of hepatocellular carcinoma cells. PMID: 24631531 Ref: Nintedanib (BIBF-1120) inhibits hepatocellular carcinoma growth independent of angiokinase activity. PMID: 24657398 Ref: Role of estrogen in hepatocellular carcinoma: is inflammation the key? PMID: 24708807 Ref: Cantharidin exerts anti-hepatocellular carcinoma by miR-214 modulating macrophage polarization. PMID: 24719559 Ref: Separating Tumorigenicity from Bile Acid Regulatory Activity for Endocrine Hormone FGF19. PMID: 24728076 Ref: A sorafenib derivative and novel SHP-1 agonist, SC-59, acts synergistically with radiotherapy in hepatocellular carcinoma cells through inhibition of STAT3. PMID: 24735751 Ref: Genomic profiling of hepatocellular adenomas reveals recurrent FRK-activating mutations and the mechanisms of malignant transformation. PMID: 24735922 Ref: Aging impairs transcriptional regulation of vascular endothelial growth factor in human microvascular endothelial cells: implications for angiogenesis and cell survival. PMID: 24781730 Ref: A preclinical evaluation of a novel multikinase inhibitor, SKLB-329, as a therapeutic agent against hepatocellular carcinoma. PMID: 24789676 Ref: Transcriptional suppression of miR-181c by hepatitis C virus enhances homeobox A1 expression. PMID: 24789793 Ref: The evaluation of p,p'-DDT exposure on cell adhesion of hepatocellular carcinoma. PMID: 24820114 Ref: RFX1-dependent activation of SHP-1 induces autophagy by a novel obatoclax derivative in hepatocellular carcinoma cells. PMID: 24952874 Ref: A novel miR-219-SMC4-JAK2/Stat3 regulatory pathway in human hepatocellular carcinoma. PMID: 24980149 Ref: NK cells are the crucial antitumor mediators when STAT3-mediated immunosuppression is blocked in hepatocellular carcinoma. PMID: 25015826 Ref: SC-2001 overcomes STAT3-mediated sorafenib resistance through RFX-1/SHP-1 activation in hepatocellular carcinoma. PMID: 25047655 Ref: Effects of mTOR-STAT3 on the migration and invasion abilities of hepatoma cell and mTOR-STAT3 expression in liver cancer. PMID: 25063062 Ref: Liver metastases induce reversible hepatic B cell dysfunction mediated by Gr-1+CD11b+ myeloid cells. PMID: 25085111 Ref: Hepatitis B virus X protein promotes hepatocellular carcinoma transformation through interleukin-6 activation of microRNA-21 expression. PMID: 25087183 Ref: Negative regulation of signal transducer and activator of transcription-3 signalling cascade by lupeol inhibits growth and induces apoptosis in hepatocellular carcinoma cells. PMID: 25101566 Ref: Tumor-associated macrophages produce interleukin 6 and signal via STAT3 to promote expansion of human hepatocellular carcinoma stem cells. PMID: 25181692 Ref: Genetic deletion of AEG-1 prevents hepatocarcinogenesis. PMID: 25193383 Ref: Western diet in ApoE-LDLR double-deficient mouse model of atherosclerosis leads to hepatic steatosis, fibrosis, and tumorigenesis. PMID: 25199052 Ref: [Effect of bear bile powder on STAT3 pathway in hepatocellular carcinoma xenograft]. PMID: 25223184 Ref: STAT3 mediates regorafenib-induced apoptosis in hepatocellular carcinoma. PMID: 25248379 Ref: The iron chelator Dp44mT inhibits hepatocellular carcinoma metastasis via N-Myc downstream-regulated gene 2 (NDRG2)/gp130/STAT3 pathway. PMID: 25261367 Ref: MPHOSPH1: a potential therapeutic target for hepatocellular carcinoma. PMID: 25269478 Ref: Lycopene attenuated hepatic tumorigenesis via differential mechanisms depending on carotenoid cleavage enzyme in mice. PMID: 25293877 Ref: Paper-based microreactor integrating cell culture and subsequent immunoassay for the investigation of cellular phosphorylation. PMID: 25421089 Ref: Genomic predictors for recurrence patterns of hepatocellular carcinoma: model derivation and validation. PMID: 25536056 Ref: The co-inhibitory pathway and cellular immune imbalance in the progress of HBV infection. PMID: 26202406 Ref: Oncogenic signaling pathways and origins of tumor-initiating stem-like cells of hepatocellular carcinomas induced by hepatitis C virus, alcohol and/or obesity. PMID: 26202636 Ref: STAT3 in hepatocellular carcinoma: new perspectives. PMID: 30190945 |
Ref: Clinicopathological characteristics of serum amyloid A-positive hepatocellular neoplasms/nodules arising in alcoholic cirrhosis. PMID: 25318388 Ref: Metformin decreases IL-22 secretion to suppress tumor growth in an orthotopic mouse model of hepatocellular carcinoma. PMID: 25370454 Ref: Hepatocellular carcinomas promote tumor-associated macrophage M2-polarization via increased B7-H3 expression. PMID: 25370943 Ref: Macrophage-secreted IL-8 induces epithelial-mesenchymal transition in hepatocellular carcinoma cells by activating the JAK2/STAT3/Snail pathway. PMID: 25405790 Ref: TREM-1, an inflammatory modulator, is expressed in hepatocellular carcinoma cells and significantly promotes tumor progression. PMID: 25465376 Ref: Spontaneous development of hepatocellular carcinoma with cancer stem cell properties in PR-SET7-deficient livers. PMID: 25515659 Ref: C-terminal-truncated hepatitis B virus X protein enhances the development of diethylnitrosamine-induced hepatocellular carcinogenesis. PMID: 25519169 Ref: 14-3-3zeta regulates immune response through Stat3 signaling in oral squamous cell carcinoma. PMID: 25556369 Ref: Activation of IL6/IGFIR confers poor prognosis of HBV-related hepatocellular carcinoma through induction of OCT4/NANOG expression. PMID: 25564572 Ref: STAT3 regulates the migration and invasion of a stemlike subpopulation through microRNA21 and multiple targets in hepatocellular carcinoma. PMID: 25571964 Ref: Lysophosphatidic acid receptor LPAR6 supports the tumorigenicity of hepatocellular carcinoma. PMID: 25589345 Ref: Copper-obatoclax derivative complexes mediate DNA cleavage and exhibit anti-cancer effects in hepatocellular carcinoma. PMID: 25598309 Ref: miR-146a is directly regulated by STAT3 in human hepatocellular carcinoma cells and involved in anti-tumor immune suppression. PMID: 25607648 Ref: Repression of microRNA-130b by thyroid hormone enhances cell motility. PMID: 25617495 Ref: SHP-1 is a negative regulator of epithelial-mesenchymal transition in hepatocellular carcinoma. PMID: 25619838 Ref: Pyruvate kinase M2 affects liver cancer cell behavior through up-regulation of HIF-1alpha and Bcl-xL in culture. PMID: 25661370 Ref: High-Mobility Group Box 1 Promotes Hepatocellular Carcinoma Progression through miR-21-Mediated Matrix Metalloproteinase Activity. PMID: 25720799 Ref: Lack of gp130 expression in hepatocytes attenuates tumor progression in the DEN model. PMID: 25741592 Ref: PML suppresses IL-6-induced STAT3 activation by interfering with STAT3 and HDAC3 interaction. PMID: 25892518 Ref: IL-6, through p-STAT3 rather than p-STAT1, activates hepatocarcinogenesis and affects survival of hepatocellular carcinoma patients: a cohort study. PMID: 25908103 Ref: Hepatitis D and hepatocellular carcinoma. PMID: 25914778 Ref: Galpha12 overexpressed in hepatocellular carcinoma reduces microRNA-122 expression via HNF4alpha inactivation, which causes c-Met induction. PMID: 25965999 Ref: Prognostic Role of Phospho-STAT3 in Patients with Cancers of the Digestive System: A Systematic Review and Meta-Analysis. PMID: 26024373 Ref: Ablation of Dicer leads to widespread perturbation of signaling pathways. PMID: 26032504 Ref: An In Vivo Method to Identify microRNA Targets Not Predicted by Computation Algorithms: p21 Targeting by miR-92a in Cancer. PMID: 26062558 Ref: Co-expression of CXCL8 and HIF-1alpha is associated with metastasis and poor prognosis in hepatocellular carcinoma. PMID: 26078356 Ref: High expression of IL-9R promotes the progression of human hepatocellular carcinoma and indicates a poor clinical outcome. PMID: 26082242 Ref: Signal transducer and activator of transcription 3-mediated CD133 up-regulation contributes to promotion of hepatocellular carcinoma. PMID: 26154152 Ref: Long-term use of indomethacin leads to poor prognoses through promoting the expression of PD-1 and PD-L2 via TRIF/NF-kappaB pathway and JAK/STAT3 pathway to inhibit TNF-alpha and IFN-gamma in hepatocellular carcinoma. PMID: 26162855 Ref: An HNF1alpha-regulated feedback circuit modulates hepatic fibrogenesis via the crosstalk between hepatocytes and hepatic stellate cells. PMID: 26169608 Ref: Leukemia inhibitory factor protects cholangiocarcinoma cells from drug-induced apoptosis via a PI3K/AKT-dependent Mcl-1 activation. PMID: 26296968 Ref: Predominant Activation of JAK/STAT3 Pathway by Interleukin-6 Is Implicated in Hepatocarcinogenesis. PMID: 26297436 Ref: Profiling of promoter occupancy by the SND1 transcriptional coactivator identifies downstream glycerolipid metabolic genes involved in TNFalpha response in human hepatoma cells. PMID: 26323317 Ref: HES5 promotes cell proliferation and invasion through activation of STAT3 and predicts poor survival in hepatocellular carcinoma. PMID: 26342546 Ref: The influence of TLR4 agonist lipopolysaccharides on hepatocellular carcinoma cells and the feasibility of its application in treating liver cancer. PMID: 26345468 Ref: Promotion of Cancer Stem-Like Cell Properties in Hepatitis C Virus-Infected Hepatocytes. PMID: 26355082 Ref: IL-17 Producing Cells and RORgammat mRNA Transcriptional Factor in Cirrhotic and HCC Egyptian Patients. PMID: 26415373 Ref: Long noncoding RNA lncTCF7, induced by IL-6/STAT3 transactivation, promotes hepatocellular carcinoma aggressiveness through epithelial-mesenchymal transition. PMID: 26452542 Ref: Molecular mechanisms underlying anticancer effects of myricetin. PMID: 26455550 Ref: STK4 regulates TLR pathways and protects against chronic inflammation-related hepatocellular carcinoma. PMID: 26457732 Ref: Loss of hepatocyte ERBB3 but not EGFR impairs hepatocarcinogenesis. PMID: 26492920 Ref: Targeted silencing of CXCL1 by siRNA inhibits tumor growth and apoptosis in hepatocellular carcinoma. PMID: 26499374 Ref: Higher proliferation of peritumoral endothelial cells to IL-6/sIL-6R than tumoral endothelial cells in hepatocellular carcinoma. PMID: 26525581 Ref: Stat3 is a candidate epigenetic biomarker of perinatal Bisphenol A exposure associated with murine hepatic tumors with implications for human health. PMID: 26542749 Ref: Hepatocyte-Specific Arid1a Deficiency Initiates Mouse Steatohepatitis and Hepatocellular Carcinoma. PMID: 26569409 Ref: Activated hepatic stellate cells promote angiogenesis via interleukin-8 in hepatocellular carcinoma. PMID: 26593962 Ref: Combination of PEI-Mn0.5Zn0.5Fe2O4 nanoparticles and pHsp 70-HSV-TK/GCV with magnet-induced heating for treatment of hepatoma. PMID: 26604760 Ref: Hydroxyflavanone inhibits gastric carcinoma MGC-803 cell proliferation. PMID: 26629250 Ref: IFN-lambda Inhibits MiR-122 Transcription through a Stat3-HNF4alpha Inflammatory Feedback Loop in an IFN-alpha Resistant HCV Cell Culture System. PMID: 26657215 |
Ref: Anti-cancer effect of N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2,3-dihydronaphtho[1,2-b]furan-2-carb oxamide, a novel synthetic compound. PMID: 25865242 Ref: CCL20-CCR6 Cytokine Network Facilitate Treg Activity in Advanced Grades and Metastatic Variants of Hepatocellular Carcinoma. PMID: 26331965 Ref: TLR4 Signaling via NANOG Cooperates With STAT3 to Activate Twist1 and Promote Formation of Tumor-Initiating Stem-Like Cells in Livers of Mice. PMID: 26582088 Ref: A combination of sorafenib and SC-43 is a synergistic SHP-1 agonist duo to advance hepatocellular carcinoma therapy. PMID: 26679051 Ref: Emodin potentiates the antiproliferative effect of interferon alpha/beta by activation of JAK/STAT pathway signaling through inhibition of the 26S proteasome. PMID: 26683360 Ref: Activating JAK1 mutation may predict the sensitivity of JAK-STAT inhibition in hepatocellular carcinoma. PMID: 26701727 Ref: Cytokine levels contribute to the pathogenesis of minimal hepatic encephalopathy in patients with hepatocellular carcinoma via STAT3 activation. PMID: 26757951 Ref: Autologous Tumor Cell Lysate-Loaded Dendritic Cell Vaccine Inhibited Tumor Progression in an Orthotopic Murine Model for Hepatocellular Carcinoma. PMID: 26786094 Ref: HBV-induced ROS accumulation promotes hepatocarcinogenesis through Snail-mediated epigenetic silencing of SOCS3. PMID: 26794444 Ref: Long non-coding RNA DILC regulates liver cancer stem cells via IL-6/STAT3 axis. PMID: 26812074 Ref: Peroxiredoxin II Is Essential for Maintaining Stemness by Redox Regulation in Liver Cancer Cells. PMID: 26866938 Ref: Differential association of STAT3 and HK-II expression in hepatitis B virus- and hepatitis C virus-related hepatocellular carcinoma. PMID: 26889748 Ref: Hepatic carcinoma-associated fibroblasts induce IDO-producing regulatory dendritic cells through IL-6-mediated STAT3 activation. PMID: 26900950 Ref: Targeting blockage of STAT3 inhibits hepatitis B virus-related hepatocellular carcinoma. PMID: 26934469 Ref: Circulating microRNAs in Hepatocellular Carcinoma: Potential Diagnostic and Prognostic Biomarkers. PMID: 26935703 Ref: Reversal of liver cancer-associated stellate cell-induced stem-like characteristics in SMMC-7721 cells by 8-bromo-7-methoxychrysin via inhibiting STAT3 activation. PMID: 26935885 Ref: Dovitinib Acts As a Novel Radiosensitizer in Hepatocellular Carcinoma by Targeting SHP-1/STAT3 Signaling. PMID: 26960749 Ref: RY10-4 Inhibits the Proliferation of Human Hepatocellular Cancer HepG2 Cells by Inducing Apoptosis In Vitro and In Vivo. PMID: 26974964 Ref: Estradiol and Estrogen Receptor Agonists Oppose Oncogenic Actions of Leptin in HepG2 Cells. PMID: 26982332 Ref: Non-CSCs nourish CSCs through interleukin-17E-mediated activation of NF-kappaB and JAK/STAT3 signaling in human hepatocellular carcinoma. PMID: 27000993 Ref: C-terminal truncated hepatitis B virus X protein promotes hepatocellular carcinogenesis through induction of cancer and stem cell-like properties. PMID: 27006468 Ref: Regulation of Multi-drug Resistance in hepatocellular carcinoma cells is TRPC6/Calcium Dependent. PMID: 27011063 Ref: Inhibiting ROS-STAT3-dependent autophagy enhanced capsaicin-induced apoptosis in human hepatocellular carcinoma cells. PMID: 27043357 Ref: TLR4 signaling promotes a COX-2/PGE2/STAT3 positive feedback loop in hepatocellular carcinoma (HCC) cells. PMID: 27057441 Ref: Recombinant soluble gp130 protein reduces DEN-induced primary hepatocellular carcinoma in mice. PMID: 27080032 Ref: Human growth hormone and human prolactin function as autocrine/paracrine promoters of progression of hepatocellular carcinoma. PMID: 27102295 Ref: Metastasized lung cancer suppression by Morinda citrifolia (Noni) leaf compared to Erlotinib via anti-inflammatory, endogenous antioxidant responses and apoptotic gene activation. PMID: 27106908 Ref: Polysaccharide from Lentinus edodes combined with oxaliplatin possesses the synergy and attenuation effect in hepatocellular carcinoma. PMID: 27130669 Ref: Protrusion-localized STAT3 mRNA promotes metastasis of highly metastatic hepatocellular carcinoma cells in vitro. PMID: 27133294 Ref: Lung Adenocarcinoma Distally Rewires Hepatic Circadian Homeostasis. PMID: 27153497 Ref: Overexpression of variant PNPLA3 gene at I148M position causes malignant transformation of hepatocytes via IL-6-JAK2/STAT3 pathway in low dose free fatty acid exposure: a laboratory investigation in vitro and in vivo. PMID: 27186262 Ref: RhoE/ROCK2 regulates chemoresistance through NF-kappaB/IL-6/ STAT3 signaling in hepatocellular carcinoma. PMID: 27213590 Ref: FAP Promotes Immunosuppression by Cancer-Associated Fibroblasts in the Tumor Microenvironment via STAT3-CCL2 Signaling. PMID: 27216177 Ref: MiR-183 modulates multi-drug resistance in hepatocellular cancer (HCC) cells via miR-183-IDH2/SOCS6-HIF-1alpha feedback loop. PMID: 27249600 Ref: (-)-Oleocanthal inhibits growth and metastasis by blocking activation of STAT3 in human hepatocellular carcinoma. PMID: 27259268 Ref: STAT3 is a key transcriptional regulator of cancer stem cell marker CD133 in HCC. PMID: 27275460 Ref: A Positive TGF-beta/c-KIT Feedback Loop Drives Tumor Progression in Advanced Primary Liver Cancer. PMID: 27292026 Ref: IL-6/STAT3 axis initiated CAFs via up-regulating TIMP-1 which was attenuated by acetylation of STAT3 induced by PCAF in HCC microenvironment. PMID: 27297362 Ref: Sustainable inflammation transforms hepatic cells by causing oxidative stress injury and potential epithelial-mesenchymal transition. PMID: 27315196 Ref: [Interferon-beta combined with all-trans retinoic acid supresses proliferation and promote apoptosis by inhibiting JAK2/STAT3 pathway in HepG2 human hepatocellular carcinoma cells]. PMID: 27363269 Ref: B cell regulation of the anti-tumor response and role in carcinogenesis. PMID: 27437104 Ref: Autocrine activity of BDNF induced by the STAT3 signaling pathway causes prolonged TrkB activation and promotes human non-small-cell lung cancer proliferation. PMID: 27456333 Ref: Effect of saracatinib on pulmonary metastases from hepatocellular carcinoma. PMID: 27460949 Ref: NEDD4 Depletion Inhibits Hepatocellular Carcinoma Growth via Targeting PTEN. PMID: 27467187 Ref: Hepatitis C virus suppresses Hepatocyte Nuclear Factor 4 alpha, a key regulator of hepatocellular carcinoma. PMID: 27477312 Ref: Polarization of Tissue-Resident TFH-Like Cells in Human Hepatoma Bridges Innate Monocyte Inflammation and M2b Macrophage Polarization. PMID: 27531854 Ref: LncSox4 promotes the self-renewal of liver tumour-initiating cells through Stat3-mediated Sox4 expression. PMID: 27553854 Ref: U/G SNP rs111904020 in 3'UTR of STAT3 regulated by miR-214 promotes hepatocellular carcinoma development in Chinese population. PMID: 27619679 Ref: Tumor control by human cytomegalovirus in a murine model of hepatocellular carcinoma. PMID: 27626063 Ref: Garcinol and Its Role in Chronic Diseases. PMID: 27671827 Ref: microRNA-539 suppresses tumor growth and tumorigenesis and overcomes arsenic trioxide resistance in hepatocellular carcinoma. PMID: 27717846 Ref: MicroRNA miR-204 and miR-1236 inhibit hepatitis B virus replication via two different mechanisms. PMID: 27734898 Ref: Role of PXR in Hepatic Cancer: Its Influences on Liver Detoxification Capacity and Cancer Progression. PMID: 27760163 Ref: Ascochlorin Enhances the Sensitivity of Doxorubicin Leading to the Reversal of Epithelial-to-Mesenchymal Transition in Hepatocellular Carcinoma. PMID: 27765853 Ref: Editorial - PHACTR4/STAT3 axis as a possible target therapy for hepatocellular carcinoma treatment. PMID: 27775809 Ref: The effect of JAK2 knockout on inhibition of liver tumor growth by inducing apoptosis, autophagy and anti-proliferation via STATs and PI3K/AKT signaling pathways. PMID: 27788478 Ref: APPL1-Mediating Leptin Signaling Contributes to Proliferation and Migration of Cancer Cells. PMID: 27820851 Ref: Investigating the mechanism of hepatocellular carcinoma progression by constructing genetic and epigenetic networks using NGS data identification and big database mining method. PMID: 27821810 Ref: TTF1, in the Form of Nanoparticles, Inhibits Angiogenesis, Cell Migration and Cell Invasion In Vitro and In Vivo in Human Hepatoma through STAT3 Regulation. PMID: 27834930 Ref: eIF5A2 is an alternative pathway for cell proliferation in cetuximab-treated epithelial hepatocellular carcinoma. PMID: 27904670 Ref: A cell-autonomous tumour suppressor role of RAF1 in hepatocarcinogenesis. PMID: 28000790 Ref: Antitumoral Activity of Sorafenib in Hepatocellular Carcinoma: Effects on Cell Survival and Death Pathways, Cell Metabolism Reprogramming, and Nitrosative and Oxidative Stress. PMID: 29431086 Ref: [Apoptosis of human hepatocellular carcinoma HepG-2 cells upon inhibition of STAT3 by 5,2',4'-trihydroxy-6,7,5'-trimethoxy flavone nanoparticle]. PMID: 29908536 |
Ref: The neuroleptic drug pimozide inhibits stem-like cell maintenance and tumorigenicity in hepatocellular carcinoma. PMID: 26061710 Ref: Cucurbitacin B exerts anti-cancer activities in human multiple myeloma cells in vitro and in vivo by modulating multiple cellular pathways. PMID: 27418139 Ref: Stat3 contributes to cancer progression by regulating Jab1/Csn5 expression. PMID: 27524414 Ref: Hepatic carcinoma-associated fibroblasts enhance immune suppression by facilitating the generation of myeloid-derived suppressor cells. PMID: 27593937 Ref: CKLF-Like MARVEL Transmembrane Domain-Containing Member 3 (CMTM3) Inhibits the Proliferation and Tumorigenisis in Hepatocellular Carcinoma Cells. PMID: 27629543 Ref: Sorafenib with ASC-J9((R)) synergistically suppresses the HCC progression via altering the pSTAT3-CCL2/Bcl2 signals. PMID: 27668844 Ref: Melatonin prevents deregulation of the sphingosine kinase/sphingosine 1-phosphate signaling pathway in a mouse model of diethylnitrosamine-induced hepatocellular carcinoma. PMID: 27696512 Ref: A tumour-promoting role of Th9 cells in hepatocellular carcinoma through CCL20 and STAT3 pathways. PMID: 27797409 Ref: Hippo signaling interactions with Wnt/beta-catenin and Notch signaling repress liver tumorigenesis. PMID: 27869648 Ref: Involvement of inflammation and its related microRNAs in hepatocellular carcinoma. PMID: 27888618 Ref: Blocking preferential glucose uptake sensitizes liver tumor-initiating cells to glucose restriction and sorafenib treatment. PMID: 27894955 Ref: Molecular Classification of Hepatocellular Adenoma Associates With Risk Factors, Bleeding, and Malignant Transformation. PMID: 27939373 Ref: Crosstalk between different family members: IL27 recapitulates IFNgamma responses in HCC cells, but is inhibited by IL6-type cytokines. PMID: 27939431 Ref: Blocking the CCL2-CCR2 Axis Using CCL2-Neutralizing Antibody Is an Effective Therapy for Hepatocellular Cancer in a Mouse Model. PMID: 27980102 Ref: Ilexgenin A exerts anti-inflammation and anti-angiogenesis effects through inhibition of STAT3 and PI3K pathways and exhibits synergistic effects with Sorafenib on hepatoma growth. PMID: 27986624 Ref: MicroRNA-340 inhibits the proliferation and invasion of hepatocellular carcinoma cells by targeting JAK1. PMID: 27998770 Ref: Scutellarin suppresses migration and invasion of human hepatocellular carcinoma by inhibiting the STAT3/Girdin/Akt activity. PMID: 27998773 Ref: Suberoylanilide hydroxamic Acid, a histone deacetylase inhibitor, alters multiple signaling pathways in hepatocellular carcinoma cell lines. PMID: 28007318 Ref: DJ-1 promotes development of DEN-induced hepatocellular carcinoma and proliferation of liver cancer cells. PMID: 28036277 Ref: miR-345 inhibits tumor metastasis and EMT by targeting IRF1-mediated mTOR/STAT3/AKT pathway in hepatocellular carcinoma. PMID: 28098858 Ref: miR-203 inhibits augmented proliferation and metastasis of hepatocellular carcinoma residual in the promoted regenerating liver. PMID: 28100026 Ref: Quantitative liver proteomics identifies FGF19 targets that couple metabolism and proliferation. PMID: 28178326 Ref: C-terminal truncated hepatitis B virus X protein regulates tumorigenicity, self-renewal and drug resistance via STAT3/Nanog signaling pathway. PMID: 28186991 Ref: Cryptotanshinone enhances the effect of Arsenic trioxide in treating liver cancer cell by inducing apoptosis through downregulating phosphorylated- STAT3 in vitro and in vivo. PMID: 28187727 Ref: Downregulation of pathways implicated in liver inflammation and tumorigenesis of glycogen storage disease type Ia mice receiving gene therapy. PMID: 28334808 Ref: Clinical implication of Frizzled 2 expression and its association with epithelial-to-mesenchymal transition in hepatocellular carcinoma. PMID: 28350091 Ref: Facilitation of liver cancer SMCC7721 cell aging by sirtuin 4 via inhibiting JAK2/STAT3 signal pathway. PMID: 28387906 Ref: Gpr110 deficiency decelerates carcinogen-induced hepatocarcinogenesis via activation of the IL-6/STAT3 pathway. PMID: 28401002 Ref: Hepatitis B virus promotes cancer cell migration by downregulating miR-340-5p expression to induce STAT3 overexpression. PMID: 28413603 Ref: Secreted GRP78 activates EGFR-SRC-STAT3 signaling and confers the resistance to sorafeinib in HCC cells. PMID: 28423613 Ref: The identification of key genes and pathways in hepatocellular carcinoma by bioinformatics analysis of high-throughput data. PMID: 28432618 Ref: SHP2 is induced by the HBx-NF-kappaB pathway and contributes to fibrosis during human early hepatocellular carcinoma development. PMID: 28460481 Ref: Radiation improves antitumor effect of immune checkpoint inhibitor in murine hepatocellular carcinoma model. PMID: 28465485 Ref: Non-cell-autonomous activation of IL-6/STAT3 signaling mediates FGF19-driven hepatocarcinogenesis. PMID: 28508871 Ref: Notch Inhibitor PF-03084014 Inhibits Hepatocellular Carcinoma Growth and Metastasis via Suppression of Cancer Stemness due to Reduced Activation of Notch1-Stat3. PMID: 28522590 Ref: Multifunctional Effects of a Small-Molecule STAT3 Inhibitor on NASH and Hepatocellular Carcinoma in Mice. PMID: 28533225 Ref: Isorhynchophylline, a Potent Plant Alkaloid, Induces Apoptotic and Anti-Metastatic Effects in Human Hepatocellular Carcinoma Cells through the Modulation of Diverse Cell Signaling Cascades. PMID: 28534824 Ref: MiR-221 mediates the epithelial-mesenchymal transition of hepatocellular carcinoma by targeting AdipoR1. PMID: 28539268 Ref: Deletion of HNF1alpha in hepatocytes results in fatty liver-related hepatocellular carcinoma in mice. PMID: 28547778 Ref: miR-30e acts as a tumor suppressor in hepatocellular carcinoma partly via JAK1/STAT3 pathway. PMID: 28560434 Ref: Activation of tumor suppressor LKB1 by honokiol abrogates cancer stem-like phenotype in breast cancer via inhibition of oncogenic Stat3. PMID: 28581518 Ref: Peretinoin, an acyclic retinoid, suppresses steatohepatitis and tumorigenesis by activating autophagy in mice fed an atherogenic high-fat diet. PMID: 28591717 Ref: Therapeutic strategies for alcoholic liver disease: Focusing on inflammation and fibrosis (Review). PMID: 28627645 Ref: Targeting the PD-L1/DNMT1 axis in acquired resistance to sorafenib in human hepatocellular carcinoma. PMID: 28627705 Ref: Knockout of the Nogo-B Gene Attenuates Tumor Growth and Metastasis in Hepatocellular Carcinoma. PMID: 28628795 Ref: A pumpkin polysaccharide induces apoptosis by inhibiting the JAK2/STAT3 pathway in human hepatoma HepG2 cells. PMID: 28634059 Ref: Secretion of interleukin-6 by bone marrow mesenchymal stem cells promotes metastasis in hepatocellular carcinoma. PMID: 28659496 Ref: Morusin shows potent antitumor activity for human hepatocellular carcinoma in vitro and in vivo through apoptosis induction and angiogenesis inhibition. PMID: 28670112 Ref: Norcantharidin inhibits IL-6-induced epithelialmesenchymal transition via the JAK2/STAT3/TWIST signaling pathway in hepatocellular carcinoma cells. PMID: 28677802 Ref: Long noncoding RNA expression profiles in sub-lethal heat-treated hepatoma carcinoma cells. PMID: 28732507 Ref: miR-500a-3p promotes cancer stem cells properties via STAT3 pathway in human hepatocellular carcinoma. PMID: 28750679 Ref: Thyroid Hormone Receptor-beta Agonist GC-1 Inhibits Met-beta-Catenin-Driven Hepatocellular Cancer. PMID: 28807594 Ref: STAT3-mediated upregulation of lncRNA HOXD-AS1 as a ceRNA facilitates liver cancer metastasis by regulating SOX4. PMID: 28810927 Ref: The STAT3 inhibitor pimozide impedes cell proliferation and induces ROS generation in human osteosarcoma by suppressing catalase expression. PMID: 28861175 Ref: 20(S)-25-methoxyl-dammarane-3beta, 12beta, 20-triol negatively regulates activation of STAT3 and ERK pathways and exhibits anti-cancer effects in HepG2 cells. PMID: 28864870 Ref: Hepatitis B Virus Activates Signal Transducer and Activator of Transcription 3 Supporting Hepatocyte Survival and Virus Replication. PMID: 28884137 Ref: Synergistic inhibitory effects on hepatocellular carcinoma with recombinant human adenovirus Aspp2 and oxaliplatin via p53-independent pathway in vitro and in vivo. PMID: 28902369 Ref: ANGPTL1 Interacts with Integrin alpha1beta1 to Suppress HCC Angiogenesis and Metastasis by Inhibiting JAK2/STAT3 Signaling. PMID: 28904065 Ref: Gene expression profiling of hepatocarcinogenesis in a mouse model of chronic hepatitis B. PMID: 28968425 Ref: Sulforaphane exerts anti-angiogenesis effects against hepatocellular carcinoma through inhibition of STAT3/HIF-1alpha/VEGF signalling. PMID: 28978924 Ref: Targeting SHP-1-STAT3 signaling: A promising therapeutic approach for the treatment of cholangiocarcinoma. PMID: 29029413 Ref: 6-Hydroxy-3-O-methyl-kaempferol 6-O-glucopyranoside potentiates the anti-proliferative effect of interferon alpha/beta by promoting activation of the JAK/STAT signaling by inhibiting SOCS3 in hepatocellular carcinoma cells. PMID: 29031523 Ref: Downregulation of A20 increases the cytotoxicity of IFN-gamma in hepatocellular carcinoma cells. PMID: 29033545 Ref: Radiosensitizing effect of ellagic acid on growth of Hepatocellular carcinoma cells: an in vitro study. PMID: 29070894 Ref: IL-17 Activates the IL-6/STAT3 Signal Pathway in the Proliferation of Hepatitis B Virus-Related Hepatocellular Carcinoma. PMID: 29073625 Ref: Attenuation of MET-mediated migration and invasion in hepatocellular carcinoma cells by SOCS1. PMID: 29085209 Ref: STAT3 deficiency prevents hepatocarcinogenesis and promotes biliary proliferation in thioacetamide-induced liver injury. PMID: 29085226 Ref: Effect of TALEN-mediated IL-6 knockout on cell proliferation, apoptosis, invasion and anti-cancer therapy in hepatocellular carcinoma (HCC-LM3) cells. PMID: 29100435 Ref: STAT3-blocked whole-cell hepatoma vaccine induces cellular and humoral immune response against HCC. PMID: 29115974 Ref: Signal Transducer and Activator of Transcription 3 for the Differentiation of Hepatocellular Carcinoma from Cirrhosis. PMID: 29133756 Ref: Santamarine Inhibits NF-small ka, CyrillicB and STAT3 Activation and Induces Apoptosis in HepG2 Liver Cancer Cells via Oxidative Stress. PMID: 29151958 Ref: Long non-coding RNA00364 represses hepatocellular carcinoma cell proliferation via modulating p-STAT3-IFIT2 signaling axis. PMID: 29254221 |
Ref: miR-135a-5p-mediated downregulation of protein tyrosine phosphatase receptor delta is a candidate driver of HCV-associated hepatocarcinogenesis. PMID: 28159835 Ref: Type I IFN augments IL-27-dependent TRIM25 expression to inhibit HBV replication. PMID: 28194021 Ref: Inhibitory Effect and Mechanism of Mesenchymal Stem Cells Cultured in 3D System on Hepatoma Cells HepG2. PMID: 28664526 Ref: Metformin incombination with curcumin inhibits the growth, metastasis, and angiogenesis of hepatocellular carcinoma in vitro and in vivo. PMID: 28833603 Ref: Detection of promoter methylation status of suppressor of cytokine signaling 3 (SOCS3) in tissue and plasma from Chinese patients with different hepatic diseases. PMID: 28951980 Ref: Heat stress induced, ligand-independent MET and EGFR signalling in hepatocellular carcinoma. PMID: 28954551 Ref: Gankyrin: a novel promising therapeutic target for hepatocellular carcinoma. PMID: 29025272 Ref: Eicosapentaenoic acid attenuates obesity-related hepatocellular carcinogenesis. PMID: 29040439 Ref: Molecular targets for the therapy of cancer associated with metabolic syndrome (transcription and growth factors). PMID: 29115033 Ref: Transforming growth factor beta1 promotes migration and invasion in HepG2 cells: Epithelialtomesenchymal transition via JAK/STAT3 signaling. PMID: 29115395 Ref: Deficiency in Protein Tyrosine Phosphatase PTP1B Shortens Lifespan and Leads to Development of Acute Leukemia. PMID: 29122767 Ref: Stimulation of Interferon-Stimulated Gene 20 by Thyroid Hormone Enhances Angiogenesis in Liver Cancer. PMID: 29195126 Ref: Maintenance of stemness by miR-589-5p in hepatocellular carcinoma cells promotes chemoresistance via STAT3 signaling. PMID: 29196128 Ref: The long noncoding RNA NEAT1 contributes to hepatocellular carcinoma development by sponging miR-485 and enhancing the expression of the STAT3. PMID: 29219178 Ref: Overexpression of interleukin-32alpha promotes invasion by modulating VEGF in hepatocellular carcinoma. PMID: 29286122 Ref: Novel 1,4-naphthoquinone derivatives induce apoptosis via ROS-mediated p38/MAPK, Akt and STAT3 signaling in human hepatoma Hep3B cells. PMID: 29326072 Ref: Diverse modes of clonal evolution in HBV-related hepatocellular carcinoma revealed by single-cell genome sequencing. PMID: 29327728 Ref: Artesunate enhances gammadelta T-cell-mediated antitumor activity through augmenting gammadelta T-cell function and reversing immune escape of HepG2 cells. PMID: 29405080 Ref: The Effect of Selective c-MET Inhibitor on Hepatocellular Carcinoma in the MET-Active, beta-Catenin-Mutated Mouse Model. PMID: 29409568 Ref: STAT3 promotes the proliferation and migration of hepatocellular carcinoma cells by regulating AKT2. PMID: 29435076 Ref: CPT2 downregulation adapts HCC to lipid-rich environment and promotes carcinogenesis via acylcarnitine accumulation in obesity. PMID: 29437870 Ref: Tumor cell-intrinsic Tim-3 promotes liver cancer via NF-kappaB/IL-6/STAT3 axis. PMID: 29449693 Ref: Natural small molecule bigelovin suppresses orthotopic colorectal tumor growth and inhibits colorectal cancer metastasis via IL6/STAT3 pathway. PMID: 29454618 Ref: Novel fused oxazepino-indoles (FOIs) attenuate liver carcinogenesis via IL-6/JAK2/STAT3 signaling blockade as evidenced through data-based mathematical modeling. PMID: 29486150 Ref: Cancer-associated fibroblasts promote stem cell-like properties of hepatocellular carcinoma cells through IL-6/STAT3/Notch signaling. PMID: 29511600 Ref: Clinicopathological significance and prognostic role of p-STAT3 in patients with hepatocellular carcinoma. PMID: 29551899 Ref: Cancer-associated fibroblasts induce PDL1+ neutrophils through the IL6-STAT3 pathway that foster immune suppression in hepatocellular carcinoma. PMID: 29556041 Ref: The anti-inflammatory NHE-06 restores antitumor immunity by targeting NF-kappaB/IL-6/STAT3 signaling in hepatocellular carcinoma. PMID: 29574282 Ref: Oncofetal gene SALL4 reactivation by hepatitis B virus counteracts miR-200c in PD-L1-induced T cell exhaustion. PMID: 29593314 Ref: Expression of embryonic liver fodrin (ELF) and stem cell markers in CD13 liver cancer stem cells. PMID: 29630108 Ref: Deletion of sphingosine kinase 1 inhibits liver tumorigenesis in diethylnitrosamine-treated mice. PMID: 29643998 Ref: Novel Indole-fused benzo-oxazepines (IFBOs) inhibit invasion of hepatocellular carcinoma by targeting IL-6 mediated JAK2/STAT3 oncogenic signals. PMID: 29651140 Ref: The SHH/Gli axis regulates CD90-mediated liver cancer stem cell function by activating the IL6/JAK2 pathway. PMID: 29722127 Ref: FABP4 suppresses proliferation and invasion of hepatocellular carcinoma cells and predicts a poor prognosis for hepatocellular carcinoma. PMID: 29733540 Ref: Polysaccharides Extracted from Rhizoma Pleionis Have Antitumor Properties In Vitro and in an H22 Mouse Hepatoma Ascites Model In Vivo. PMID: 29735884 Ref: miR-337-3p suppresses the proliferation and invasion of hepatocellular carcinoma cells through targeting JAK2. PMID: 29736311 Ref: Group I Paks support muscle regeneration and counteract cancer-associated muscle atrophy. PMID: 29781585 Ref: LncRNA TUG1 interacting with miR-144 contributes to proliferation, migration and tumorigenesis through activating the JAK2/STAT3 pathway in hepatocellular carcinoma. PMID: 29791864 Ref: TLR2/4 ligand-amplified liver inflammation promotes initiation of autoimmune hepatitis due to sustained IL-6/IL-12/IL-4/IL-25 expression. PMID: 29793131 Ref: Chemical and genetic inhibition of STAT3 sensitizes hepatocellular carcinoma cells to sorafenib induced cell death. PMID: 29805309 Ref: Essential Oil Derived From Eupatorium adenophorum Spreng. Mediates Anticancer Effect by Inhibiting STAT3 and AKT Activation to Induce Apoptosis in Hepatocellular Carcinoma. PMID: 29867489 Ref: Liver Cancer Initiation Requires p53 Inhibition by CD44-Enhanced Growth Factor Signaling. PMID: 29894692 Ref: Compound K Induces Endoplasmic Reticulum Stress and Apoptosis in Human Liver Cancer Cells by Regulating STAT3. PMID: 29921768 Ref: EGFL7: Master regulator of cancer pathogenesis, angiogenesis and an emerging mediator of bone homeostasis. PMID: 29923200 Ref: Differential Sensitivity of Human Hepatocellular Carcinoma Xenografts to an IGF-II Neutralizing Antibody May Involve Activated STAT3. PMID: 29933129 Ref: PRMT1 Promoted HCC Growth and Metastasis In Vitro and In Vivo via Activating the STAT3 Signalling Pathway. PMID: 29945155 Ref: Fatty acid binding protein 5 promotes tumor angiogenesis and activates the IL6/STAT3/VEGFA pathway in hepatocellular carcinoma. PMID: 29957468 Ref: Mulberry leaf extract inhibit hepatocellular carcinoma cell proliferation via depressing IL-6 and TNF-alpha derived from adipocyte. PMID: 29976395 Ref: Antitumor Efficacy of Huqizhengxiao (HQZX) Decoction Based on Inhibition of Telomerase Activity in Nude Mice of Hepatocarcinoma Xenograft. PMID: 29978739 Ref: Tumor necrosis factor-alpha promotes hepatocellular carcinogenesis through the activation of hepatic progenitor cells. PMID: 29981431 Ref: LINC01287/miR-298/STAT3 feedback loop regulates growth and the epithelial-to-mesenchymal transition phenotype in hepatocellular carcinoma cells. PMID: 30001751 Ref: Overexpression of Rac GTPase Activating Protein 1 Contributes to Proliferation of Cancer Cells by Reducing Hippo Signaling to Promote Cytokinesis. PMID: 30009820 Ref: Schistosoma mansoni egg secreted antigens activate HCC-associated transcription factors c-Jun and STAT3 in hamster and human hepatocytes. PMID: 30053321 Ref: CEP55 Promotes Cell Motility via JAK2(-)STAT3(-)MMPs Cascade in Hepatocellular Carcinoma. PMID: 30096813 Ref: Antioxidant and apoptotic effects of Callistemon lanceolatus leaves and their compounds against human cancer cells. PMID: 30119188 Ref: Cannabidiol (CBD) Is a Novel Inhibitor for Exosome and Microvesicle (EMV) Release in Cancer. PMID: 30150937 Ref: [10-gingerol inhibits proliferation of hepatocellular carcinoma HepG2 cells via Src/STAT3 signaling pathway]. PMID: 30187878 Ref: IL-37b suppresses epithelial mesenchymal transition in hepatocellular carcinoma by inhibiting IL-6/STAT3 signaling. PMID: 30201411 Ref: The STAT3 inhibitor S3I-201 suppresses fibrogenesis and angiogenesis in liver fibrosis. PMID: 30206312 Ref: Chemopreventive and antitumor effects of benzyl isothiocynate on HCC models: A possible role of HGF /pAkt/ STAT3 axis and VEGF. PMID: 30216802 Ref: PRMT1-dependent macrophage IL6 production is required for alcohol-induced HCC progression. PMID: 30236171 Ref: MiR-137 suppresses migration and invasion by targeting EZH2-STAT3 signaling in human hepatocellular carcinoma. PMID: 30274685 Ref: Sorafenib inhibits caspase-1 expression through suppressing TLR4/stat3/SUMO1 pathway in hepatocellular carcinoma. PMID: 30277836 Ref: LINC01433 promotes hepatocellular carcinoma progression via modulating the miR-1301/STAT3 axis. PMID: 30317567 Ref: Endoplasmic reticulum resident oxidase ERO1-Lalpha promotes hepatocellular carcinoma metastasis and angiogenesis through the S1PR1/STAT3/VEGF-A pathway. PMID: 30377291 Ref: NEAT1 paraspeckle promotes human hepatocellular carcinoma progression by strengthening IL-6/STAT3 signaling. PMID: 30377567 Ref: Expression and prognostic value of HER-2/neu, STAT3 and SOCS3 in hepatocellular carcinoma. PMID: 30385249 |