Primary Site >> Colorectal Cancer

Gene >> STAT3

Journal: J Immunol. 1996 Apr 15;156(8):2972-8.
Title: IL-13 induces phosphorylation and activation of JAK2 Janus kinase in human colon carcinoma cell lines: similarities between IL-4 and IL-13 signaling.
Author: Murata, T|Noguchi, P D|Puri, R K
PMID: 8609418
Journal: Biochem Pharmacol. 2000 Oct 1;60(7):885-98.
Title: Biochemical and cellular effects of c-Src kinase-selective pyrido[2, 3-d]pyrimidine tyrosine kinase inhibitors.
Author: Kraker, A J|Hartl, B G|Amar, A M|Barvian, M R|Showalter, H D|Moore, C W
PMID: 10974196
Journal: Oncogene. 2002 Jul 25;21(32):4997-5001.
Title: Gamma interferon down-regulates Fer and induces its association with inactive Stat3 in colon carcinoma cells.
Author: Orlovsky, Kira|Theodor, Livia|Malovani, Hana|Chowers, Yehuda|Nir, Uri
PMID: 12118379
Journal: Mol Cancer Ther. 2003 May;2(5):461-9.
Title: Src family kinase activity is required for signal tranducer and activator of transcription 3 and focal adhesion kinase phosphorylation and vascular endothelial growth factor signaling in vivo and for anchorage-dependent and -independent growth of human tu
Author: Laird, A Douglas|Li, Guangmin|Moss, Katherine G|Blake, Robert A|Broome, Martin A|Cherrington, Julie M|Mendel, Dirk B
PMID: 12748308
Journal: Beijing Da Xue Xue Bao. 2003 Feb 18;35(1):50-3.
Title: [Stat3 signal transduction pathway orchestrates G1 to S cell cycle transition in colon cancer cells].
Author: Ma, Xiangtao|Wang, Shan|Du, Ruyu|Ye, Yingjiang|Wang, Shu|Yan, Feifei|Cui, Zhirong
PMID: 12920809
Journal: Ai Zheng. 2003 Nov;22(11):1135-9.
Title: [Relationship of Stat3 and its target gene products with malignancy in human colorectal carcinoma].
Author: Ma, Xiang-Tao|Wang, Shan|Ye, Ying-Jiang|Du, Ru-Yu|Cui, Zhi-Rong
PMID: 14613639
Journal: J Immunol. 2004 Apr 1;172(7):4630-6.
Title: Recruitment of STAT3 for production of IL-10 by colon carcinoma cells induced by macrophage-derived IL-6.
Author: Herbeuval, Jean-Philippe|Lelievre, Eric|Lambert, Claude|Dy, Michel|Genin, Christian
PMID: 15034082
Journal: Oncogene. 2004 Apr 22;23(19):3317-27.
Title: Disruption of STAT3 signaling leads to tumor cell invasion through alterations of homotypic cell-cell adhesion complexes.
Author: Rivat, Christine|De Wever, Olivier|Bruyneel, Erik|Mareel, Marc|Gespach, Christian|Attoub, Samir
PMID: 15077188
Journal: World J Gastroenterol. 2004 Jun 1;10(11):1569-73.
Title: Constitutive activation of Stat3 signaling pathway in human colorectal carcinoma.
Author: Ma, Xiang-Tao|Wang, Shan|Ye, Ying-Jiang|Du, Ru-Yu|Cui, Zhi-Rong|Somsouk, Ma
PMID: 15162527
Journal: Eur J Histochem. 2004 Jul-Sep;48(3):291-7.
Title: Immunohistochemical expression of HGF, c-MET and transcription factor STAT3 in colorectal tumors.
Author: Trovato, M|Vitarelli, E|Grosso, M|Alesci, S|Benvenga, S|Trimarchi, F|Barresi, G
PMID: 15590419
Journal: Cancer Res. 2004 Dec 15;64(24):9105-14.
Title: Elimination of hepatic metastases of colon cancer cells via p53-independent cross-talk between irinotecan and Apo2 ligand/TRAIL.
Author: Ravi, Rajani|Jain, Ajay J|Schulick, Richard D|Pham, Vui|Prouser, Traci S|Allen, Heather|Mayer, Elizabeth Garrett|Yu, Hua|Pardoll, Drew M|Ashkenazi, Avi|Bedi, Atul
PMID: 15604280
Journal: Mol Cancer Ther. 2004 Dec;3(12):1533-42.
Title: Inhibition of constitutive signal transducer and activator of transcription 3 activation by novel platinum complexes with potent antitumor activity.
Author: Turkson, James|Zhang, Shumin|Palmer, Jay|Kay, Heidi|Stanko, Joseph|Mora, Linda B|Sebti, Said|Yu, Hua|Jove, Richard
PMID: 15634646
Journal: J Exp Ther Oncol. 2004 Dec;4(4):267-79.
Title: Atiprimod is an inhibitor of cancer cell proliferation and angiogenesis.
Author: Shailubhai, Kunwar|Dheer, Surendra|Picker, Donald|Kaur, Gurmeet|Sausville, Edward A|Jacob, Gary S
PMID: 15844657
Journal: Oncogene. 2005 Jan 6;24(1):148-56.
Title: The broad-range cyclin-dependent kinase inhibitor UCN-01 induces apoptosis in colon carcinoma cells through transcriptional suppression of the Bcl-x(L) protein.
Author: Bhonde, Mandar R|Hanski, Marie-Luise|Magrini, Roberta|Moorthy, Dhatchana|Muller, Antje|Sausville, Edward A|Kohno, Kimitoshi|Wiegand, Peter|Daniel, Peter T|Zeitz, Martin|Hanski, Christoph
PMID: 15467762
Journal: Carcinogenesis. 2005 Mar;26(3):665-71. Epub 2004 Dec 23.
Title: Augmentation of differentiation and gap junction function by kaempferol in partially differentiated colon cancer cells.
Author: Nakamura, Yasushi|Chang, Chia-Cheng|Mori, Toshio|Sato, Kenji|Ohtsuki, Kozo|Upham, Brad L|Trosko, James E
PMID: 15618237
Journal: Cancer Res. 2005 Jan 1;65(1):195-202.
Title: Implication of STAT3 signaling in human colonic cancer cells during intestinal trefoil factor 3 (TFF3) -- and vascular endothelial growth factor-mediated cellular invasion and tumor growth.
Author: Rivat, Christine|Rodrigues, Sylvie|Bruyneel, Erik|Pietu, Genevieve|Robert, Amelie|Redeuilh, Gerard|Bracke, Marc|Gespach, Christian|Attoub, Samir
PMID: 15665295
Journal: Gastroenterology. 2005 Jul;129(1):185-203.
Title: Growth hormone inhibits signal transducer and activator of transcription 3 activation and reduces disease activity in murine colitis.
Author: Han, Xiaonan|Sosnowska, Danuta|Bonkowski, Erin L|Denson, Lee A
PMID: 16012947
Journal: Neoplasia. 2005 Jun;7(6):545-55.
Title: Persistent STAT3 activation in colon cancer is associated with enhanced cell proliferation and tumor growth.
Author: Corvinus, Florian M|Orth, Carina|Moriggl, Richard|Tsareva, Svetlana A|Wagner, Stefan|Pfitzner, Edith B|Baus, Daniela|Kaufmann, Roland|Huber, Lukas A|Zatloukal, Kurt|Beug, Hartmut|Ohlschlager, Peter|Schutz, Alexander|Halbhuber, Karl-Jurgen|Friedrich, Karlh
PMID: 16036105
Journal: J Clin Pathol. 2005 Aug;58(8):833-8.
Title: Expression of p-STAT3 in human colorectal adenocarcinoma and adenoma; correlation with clinicopathological factors.
Author: Kusaba, T|Nakayama, T|Yamazumi, K|Yakata, Y|Yoshizaki, A|Nagayasu, T|Sekine, I
PMID: 16049285
Journal: Clin Rev Allergy Immunol. 2005 Jun;28(3):187-96.
Title: Involvement of IL-6 in the pathogenesis of inflammatory bowel disease and colon cancer.
Author: Atreya, Raja|Neurath, Markus F
PMID: 16129903
Journal: Am J Pathol. 2005 Oct;167(4):969-80.
Title: Constitutive activation of JAK3/STAT3 in colon carcinoma tumors and cell lines: inhibition of JAK3/STAT3 signaling induces apoptosis and cell cycle arrest of colon carcinoma cells.
Author: Lin, Quan|Lai, Raymond|Chirieac, Lucian R|Li, Changping|Thomazy, Vilmos A|Grammatikakis, Ioannis|Rassidakis, George Z|Zhang, Wei|Fujio, Yasushi|Kunisada, Keita|Hamilton, Stanley R|Amin, Hesham M
PMID: 16192633
Journal: Zhonghua Yi Xue Za Zhi. 2005 Nov 2;85(41):2899-904.
Title: [Correlation between Stat3 signal transduction pathway and expression of cyclooxygenase-2 in colorectal cancer cells].
Author: Zhang, Hui|Wang, Shan|Zhang, You-cheng|Ye, Ying-jiang|Cui, Zhi-rong|Fang, Wei-gang
PMID: 16324362
Journal: Int J Colorectal Dis. 2006 Sep;21(6):573-81. Epub 2005 Nov 15.
Title: Functional expression of the interleukin-11 receptor alpha-chain in normal colonic epithelium and colon cancer.
Author: Deutscher, Nicole|Bataille, Frauke|Hausmann, Martin|Kiessling, Stephan|Muller-Newen, Gerhard|Leeb, Sandra N|Herfarth, Hans|Heinrich, Peter C|Scholmerich, Jurgen|Rogler, Gerhard
PMID: 16292518
Journal: Mol Cell Endocrinol. 2006 Mar 9;247(1-2):140-9. Epub 2006 Jan 27.
Title: Glycine-extended gastrin inhibits apoptosis in colon cancer cells via separate activation of Akt and JNK pathways.
Author: Beales, Ian L P|Ogunwobi, O
PMID: 16442704
Journal: J Biol Chem. 2006 Mar 31;281(13):8829-35. Epub 2006 Feb 2.
Title: A growth-suppressive function for the c-fes protein-tyrosine kinase in colorectal cancer.
Author: Delfino, Frank J|Stevenson, Heather|Smithgall, Thomas E
PMID: 16455651
Journal: Cancer Res. 2006 Mar 15;66(6):2913-7.
Title: Signal transducers and activators of transcription 3 activation is involved in nuclear accumulation of beta-catenin in colorectal cancer.
Author: Kawada, Mayumi|Seno, Hiroshi|Uenoyama, Yoshito|Sawabu, Tateo|Kanda, Naoki|Fukui, Hirokazu|Shimahara, Yasuyuki|Chiba, Tsutomu
PMID: 16540637
Journal: Carcinogenesis. 2006 Jul;27(7):1507-15. Epub 2006 Apr 5.
Title: Interleukin-6 production induced by leptin treatment promotes cell proliferation in an Apc (Min/+) colon epithelial cell line.
Author: Fenton, Jenifer I|Hursting, Stephen D|Perkins, Susan N|Hord, Norman G
PMID: 16597643
Journal: Oncol Rep. 2006 Jun;15(6):1445-51.
Title: Activation of STAT3 is a marker of poor prognosis in human colorectal cancer.
Author: Kusaba, Takafumi|Nakayama, Toshiyuki|Yamazumi, Kazuyuki|Yakata, Yuichi|Yoshizaki, Ayumi|Inoue, Kenichiro|Nagayasu, Takeshi|Sekine, Ichiro
PMID: 16685378
Journal: Biochem J. 2006 Sep 15;398(3):577-83.
Title: Functional expression of a biologically active fragment of soluble gp130 as an ELP-fusion protein in transgenic plants: purification via inverse transition cycling.
Author: Lin, Meng|Rose-John, Stefan|Grotzinger, Joachim|Conrad, Udo|Scheller, Jurgen
PMID: 16716147
Journal: J Exp Med. 2006 Jun 12;203(6):1391-7. Epub 2006 May 22.
Title: IFNgamma-dependent, spontaneous development of colorectal carcinomas in SOCS1-deficient mice.
Author: Hanada, Toshikatsu|Kobayashi, Takashi|Chinen, Takatoshi|Saeki, Kazuko|Takaki, Hiromi|Koga, Keiko|Minoda, Yasumasa|Sanada, Takahito|Yoshioka, Tomoko|Mimata, Hiromitsu|Kato, Seiya|Yoshimura, Akihiko
PMID: 16717119
Journal: Clin Cancer Res. 2006 Aug 1;12(15):4720-9.
Title: Antisense to cyclin D1 inhibits vascular endothelial growth factor-stimulated growth of vascular endothelial cells: implication of tumor vascularization.
Author: Yasui, Masayoshi|Yamamoto, Hirofumi|Ngan, Chew Yee|Damdinsuren, Bazarragchaa|Sugita, Yurika|Fukunaga, Hiroki|Gu, Jinyu|Maeda, Makiko|Takemasa, Ichiro|Ikeda, Masataka|Fujio, Yasushi|Sekimoto, Mitsugu|Matsuura, Nariaki|Weinstein, I Bernard|Monden, Morito
PMID: 16899623
Journal: Int J Colorectal Dis. 2007 Apr;22(4):401-9. Epub 2006 Aug 16.
Title: The anti-apoptotic and growth stimulatory actions of leptin in human colon cancer cells involves activation of JNK mitogen activated protein kinase, JAK2 and PI3 kinase/Akt.
Author: Ogunwobi, Olorunseun O|Beales, Ian L P
PMID: 16912864
Journal: J Biol Chem. 2007 Feb 23;282(8):5413-9. Epub 2006 Dec 27.
Title: PRL3 promotes cell invasion and proliferation by down-regulation of Csk leading to Src activation.
Author: Liang, Fubo|Liang, Jiao|Wang, Wei-Qing|Sun, Jin-Peng|Udho, Eshwar|Zhang, Zhong-Yin
PMID: 17192274
Journal: J Clin Pathol. 2007 Feb;60(2):173-9.
Title: STAT3 mRNA and protein expression in colorectal cancer: effects on STAT3-inducible targets linked to cell survival and proliferation.
Author: Lassmann, Silke|Schuster, Ingrid|Walch, Axel|Gobel, Heike|Jutting, Uta|Makowiec, Frank|Hopt, Ulrich|Werner, Martin
PMID: 17264243
Journal: Virchows Arch. 2007 Mar;450(3):321-8. Epub 2007 Jan 30.
Title: Co-expression of EGF receptor, TGFalpha and S6 kinase is significantly associated with colorectal carcinomas with distant metastases at diagnosis.
Author: Tampellini, Marco|Longo, Marina|Cappia, Susanna|Bacillo, Elisa|Alabiso, Irene|Volante, Marco|Dogliotti, Luigi|Papotti, Mauro
PMID: 17265080
Journal: Oncogene. 2007 Jul 19;26(33):4833-41. Epub 2007 Feb 12.
Title: Suppressor of cytokine signaling 3 (SOCS3) limits damage-induced crypt hyper-proliferation and inflammation-associated tumorigenesis in the colon.
Author: Rigby, R J|Simmons, J G|Greenhalgh, C J|Alexander, W S|Lund, P K
PMID: 17297444
Journal: Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4060-4. Epub 2007 Feb 21.
Title: Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T.
Author: Zhang, Xiaodong|Guo, Ailan|Yu, Jianshi|Possemato, Anthony|Chen, Yueting|Zheng, Weiping|Polakiewicz, Roberto D|Kinzler, Kenneth W|Vogelstein, Bert|Velculescu, Victor E|Wang, Zhenghe John
PMID: 17360477
Journal: J Biol Chem. 2007 Jun 1;282(22):16006-15. Epub 2007 Apr 16.
Title: The interleukin-22/STAT3 pathway potentiates expression of inducible nitric-oxide synthase in human colon carcinoma cells.
Author: Ziesche, Elisabeth|Bachmann, Malte|Kleinert, Hartmut|Pfeilschifter, Josef|Muhl, Heiko
PMID: 17438334
Journal: Gut. 2007 Sep;56(9):1257-65. Epub 2007 Apr 20.
Title: Interleukin 31 mediates MAP kinase and STAT1/3 activation in intestinal epithelial cells and its expression is upregulated in inflammatory bowel disease.
Author: Dambacher, Julia|Beigel, Florian|Seiderer, Julia|Haller, Dirk|Goke, Burkhard|Auernhammer, Christoph J|Brand, Stephan
PMID: 17449633
Journal: Neoplasia. 2007 Apr;9(4):279-91.
Title: Signal transducer and activator of transcription 3 activation promotes invasive growth of colon carcinomas through matrix metalloproteinase induction.
Author: Tsareva, Svetlana A|Moriggl, Richard|Corvinus, Florian M|Wiederanders, Bernd|Schutz, Alexander|Kovacic, Boris|Friedrich, Karlheinz
PMID: 17460772
Journal: J Biol Chem. 2007 Jul 6;282(27):19399-409. Epub 2007 May 12.
Title: Eps8 facilitates cellular growth and motility of colon cancer cells by increasing the expression and activity of focal adhesion kinase.
Author: Maa, Ming-Chei|Lee, Jenq-Chang|Chen, Yen-Jen|Chen, Yun-Ju|Lee, Yuch-Ching|Wang, Shan-Tair|Huang, Ching-Chung|Chow, Nan-Haw|Leu, Tzeng-Horng
PMID: 17496330
Journal: Ai Zheng. 2007 Jul;26(7):683-7.
Title: [Correlations of GRIM-19 and its target gene product STAT3 to malignancy of human colorectal carcinoma].
Author: Gong, Long-Bo|Luo, Xue-Lai|Liu, Shuang-You|Tao, De-Ding|Gong, Jian-Ping|Hu, Jun-Bo
PMID: 17626740
Journal: J Cancer Res Clin Oncol. 2008 May;134(5):551-9. Epub 2007 Oct 6.
Title: Stat3 up-regulates expression of nicotinamide N-methyltransferase in human cancer cells.
Author: Tomida, Mikio|Ohtake, Hideki|Yokota, Takashi|Kobayashi, Yasuhito|Kurosumi, Masafumi
PMID: 17922140
Journal: Front Biosci. 2008 Jan 1;13:2888-99.
Title: The role of signal transducers and activators of transcription in colon cancer.
Author: Klampfer, Lidija
PMID: 17981761
Journal: World J Gastroenterol. 2008 Jan 21;14(3):428-34.
Title: Inhibition of signal transducer and activator of transcription 3 expression by RNA interference suppresses invasion through inducing anoikis in human colon cancer cells.
Author: Fan, Yu|Zhang, You-Li|Wu, Ying|Zhang, Wei|Wang, Yin-Huan|Cheng, Zhao-Ming|Li, Hua
PMID: 18200666
Journal: Cancer Res. 2008 Feb 1;68(3):815-25.
Title: The EGFR-STAT3 oncogenic pathway up-regulates the Eme1 endonuclease to reduce DNA damage after topoisomerase I inhibition.
Author: Vigneron, Arnaud|Gamelin, Erick|Coqueret, Olivier
PMID: 18245483
Journal: Neoplasia. 2008 Mar;10(3):287-97.
Title: Inhibition of JAK1, 2/STAT3 signaling induces apoptosis, cell cycle arrest, and reduces tumor cell invasion in colorectal cancer cells.
Author: Xiong, Hua|Zhang, Zhi-Gang|Tian, Xiao-Qing|Sun, Dan-Feng|Liang, Qin-Chuan|Zhang, Yan-Jie|Lu, Rong|Chen, Ying-Xuan|Fang, Jing-Yuan
PMID: 18320073
Journal: Cancer Biomark. 2008;4(2):83-91.
Title: Identification of a functional EGF-R/p60c-src/STAT3 pathway in colorectal carcinoma: analysis of its long-term prognostic value.
Author: Hbibi, A Tadlaoui|Lagorce, C|Wind, P|Spano, J P|Des Guetz, G|Milano, G|Benamouzig, R|Rixe, O|Morere, J-F|Breau, J-L|Martin, A|Fagard, R
PMID: 18503159
Journal: Biochem Pharmacol. 2008 Jul 15;76(2):198-207.
Title: Activated kRas protects colon cancer cells from cucurbitacin-induced apoptosis: the role of p53 and p21.
Author: Escandell, Jose M|Kaler, Pawan|Recio, M Carmen|Sasazuki, Takehiko|Shirasawa, Senji|Augenlicht, Leonard|Rios, Jose-Luis|Klampfer, Lidija
PMID: 18561895
Journal: BMC Cell Biol. 2008 Aug 1;9:43.
Title: Single cell cytometry of protein function in RNAi treated cells and in native populations.
Author: LaPan, Peter|Zhang, Jing|Pan, Jing|Hill, Andrew|Haney, Steven A
PMID: 18673568
Journal: Oncol Rep. 2008 Dec;20(6):1321-7.
Title: Guggulsterone inhibits angiogenesis by blocking STAT3 and VEGF expression in colon cancer cells.
Author: Kim, Eun Soo|Hong, Sung Yi|Lee, Hye Kyung|Kim, Seung Won|An, Min Ji|Kim, Tae Il|Lee, Kyoung Ryul|Kim, Won Ho|Cheon, Jae Hee
PMID: 19020709
Journal: J Cancer Res Clin Oncol. 2009 Mar;135(3):395-402.
Title: Epidermal growth factor receptor status and persistent activation of Akt and p44/42 MAPK pathways correlate with the effect of cetuximab in head and neck and colon cancer cell lines.
Author: Yamatodani, Takashi|Ekblad, Lars|Kjellen, Elisabeth|Johnsson, Anders|Mineta, Hiroyuki|Wennerberg, Johan
PMID: 18813952
Journal: Chem Biol Interact. 2009 Jan 27;177(2):128-36.
Title: Melatonin suppresses AOM/DSS-induced large bowel oncogenesis in rats.
Author: Tanaka, Takuji|Yasui, Yumiko|Tanaka, Mayu|Tanaka, Takahiro|Oyama, Takeru|Rahman, K M Wahidur
PMID: 19028472
Journal: J Natl Cancer Inst. 2009 Feb 4;101(3):162-75.
Title: A germline mutation (A339V) in thyroid transcription factor-1 (TITF-1/NKX2.1) in patients with multinodular goiter and papillary thyroid carcinoma.
Author: Ngan, Elly S W|Lang, Brian H H|Liu, Tingting|Shum, Cathy K Y|So, Man-Ting|Lau, Danny K C|Leon, Thomas Y Y|Cherny, Stacey S|Tsai, Sophia Y|Lo, Chung-Yau|Khoo, Ui-Soon|Tam, Paul K H|Garcia-Barcelo, Maria-Merce
PMID: 19176457
Journal: Cancer Cell. 2009 Feb 3;15(2):79-80.
Title: Inflammation and cancer: IL-6 and STAT3 complete the link.
Author: Bromberg, Jacqueline|Wang, Timothy C
PMID: 19185839
Journal: Cell Immunol. 2009;256(1-2):19-26.
Title: Macrophage-derived interleukin-6 up-regulates MUC1, but down-regulates MUC2 expression in the human colon cancer HT-29 cell line.
Author: Li, Ying-Ying|Hsieh, Ling-Ling|Tang, Rei-Ping|Liao, Shuen-Keui|Yeh, Kun-Yun
PMID: 19201396
Journal: Hum Immunol. 2009 Mar;70(3):151-8.
Title: Interleukin-6 (IL-6) released by macrophages induces IL-6 secretion in the human colon cancer HT-29 cell line.
Author: Li, Ying-Ying|Hsieh, Ling-Ling|Tang, Rei-Ping|Liao, Shuen-Keui|Yeh, Kun-Yun
PMID: 19272324
Journal: Biochim Biophys Acta. 2009 Mar;1793(3):477-88.
Title: Expression of gastrin precursors by CD133-positive colorectal cancer cells is crucial for tumour growth.
Author: Ferrand, Audrey|Sandrin, Mauro S|Shulkes, Arthur|Baldwin, Graham S
PMID: 19321126
Journal: Exp Mol Pathol. 2009 Aug;87(1):36-41.
Title: Association of early phase of colorectal carcinogenesis with STAT3 activation and its relevance in apoptosis regulation.
Author: Baral, Rathindranath|Bose, Anamika|Ray, Chinmoyee|Paul, Sonali|Pal, Smarajit|Haque, Enamul|Mishra, Bhagawan|Pal, Debolina|Nagpal, Jatin Kumar|Panda, Chinmay Kumar|Das, Bibhu Ranjan
PMID: 19341726
Journal: Clin Cancer Res. 2009 Apr 15;15(8):2647-56.
Title: Role of eotaxin-1 signaling in ovarian cancer.
Author: Levina, Vera|Nolen, Brian M|Marrangoni, Adele M|Cheng, Peng|Marks, Jeffrey R|Szczepanski, Miroslaw J|Szajnik, Marta E|Gorelik, Elieser|Lokshin, Anna E
PMID: 19351767
Journal: FEBS J. 2009 May;276(9):2505-15.
Title: Efficient killing of SW480 colon carcinoma cells by a signal transducer and activator of transcription (STAT) 3 hairpin decoy oligodeoxynucleotide--interference with interferon-gamma-STAT1-mediated killing.
Author: Tadlaoui Hbibi, Ali|Laguillier, Christelle|Souissi, Ines|Lesage, Denis|Le Coquil, Stephanie|Cao, An|Metelev, Valeri|Baran-Marszak, Fanny|Fagard, Remi
PMID: 19476491
Journal: Acta Pharmacol Sin. 2009 Jul;30(7):1039-45.
Title: alpha2,6-hyposialylation of c-Met abolishes cell motility of ST6Gal-I-knockdown HCT116 cells.
Author: Qian, Jin|Zhu, Cai-Hua|Tang, Shuai|Shen, Ai-Jun|Ai, Jing|Li, Jing|Geng, Mei-Yu|Ding, Jian
PMID: 19483716
Journal: J Cell Physiol. 2009 Oct;221(1):189-94.
Title: Expression of angiogenic regulators, VEGF and leptin, is regulated by the EGF/PI3K/STAT3 pathway in colorectal cancer cells.
Author: Cascio, Sandra|Ferla, Rita|D'Andrea, Aleco|Gerbino, Aldo|Bazan, Viviana|Surmacz, Eva|Russo, Antonio
PMID: 19492417
Journal: Curr Pharm Des. 2009;15(18):2095-103.
Title: Interleukin-6 trans-signaling and colonic cancer associated with inflammatory bowel disease.
Author: Rose-John, Stefan|Mitsuyama, Keiichi|Matsumoto, Satoshi|Thaiss, Wolfgang M|Scheller, Jurgen
PMID: 19519447
Journal: Exp Mol Med. 2009 Oct 31;41(10):717-27.
Title: Triptolide downregulates Rac1 and the JAK/STAT3 pathway and inhibits colitis-related colon cancer progression.
Author: Wang, Zhipeng|Jin, Haifeng|Xu, Ruodan|Mei, Qibing|Fan, Daiming
PMID: 19561401
Journal: Cancer Biol Ther. 2009 Sep;8(17):1671-9. Epub 2009 Sep 20.
Title: Mirk/Dyrk1B, a novel therapeutic target, mediates cell survival in non-small cell lung cancer cells.
Author: Gao, Jingchun|Zheng, Zhong|Rawal, Bhupendra|Schell, Michael J|Bepler, Gerold|Haura, Eric B
PMID: 19633423
Journal: Nat Med. 2009 Sep;15(9):1016-22.
Title: A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses.
Author: Wu, Shaoguang|Rhee, Ki-Jong|Albesiano, Emilia|Rabizadeh, Shervin|Wu, Xinqun|Yen, Hung-Rong|Huso, David L|Brancati, Frederick L|Wick, Elizabeth|McAllister, Florencia|Housseau, Franck|Pardoll, Drew M|Sears, Cynthia L
PMID: 19701202
Journal: Int J Oncol. 2009 Nov;35(5):1037-43.
Title: Synergistic effects of lovastatin and celecoxib on caveolin-1 and its down-stream signaling molecules: Implications for colon cancer prevention.
Author: Guruswamy, Suresh|Rao, Chinthalapally V
PMID: 19787257
Journal: J Cell Mol Med. 2009 Sep;13(9B):3668-79.
Title: Inhibition of DNA methyltransferase induces G2 cell cycle arrest and apoptosis in human colorectal cancer cells via inhibition of JAK2/STAT3/STAT5 signalling.
Author: Xiong, Hua|Chen, Zhao-Fei|Liang, Qin-Chuan|Du, Wan|Chen, Hui-Min|Su, Wen-Yu|Chen, Guo-Qiang|Han, Ze-Guang|Fang, Jing-Yuan
PMID: 20196786
Journal: Arab J Gastroenterol. 2009 Mar;10(1):25-32.
Title: Expression of the signal transducer and activator of transcription factor 3 and Janus kinase 3 in colorectal carcinomas, colonic adenomas and ulcerative colitis.
Author: Shareef, Mohamed M|Shamloula, Maha M|Elfert, Asem A|El-Sawaf, Mohamed|Soliman, Hanan H
PMID: 24842133
Journal: Gut. 2010 Feb;59(2):227-35.
Title: Disease-related expression of the IL6/STAT3/SOCS3 signalling pathway in ulcerative colitis and ulcerative colitis-related carcinogenesis.
Author: Li, Yi|de Haar, Colin|Chen, Min|Deuring, Jasper|Gerrits, Monique M|Smits, Ron|Xia, Bing|Kuipers, Ernst J|van der Woude, C Janneke
PMID: 19926618
Journal: Mol Nutr Food Res. 2010 Apr;54(4):559-65.
Title: Cucurbitacin B induces G2 arrest and apoptosis via a reactive oxygen species-dependent mechanism in human colon adenocarcinoma SW480 cells.
Author: Yasuda, Shusuke|Yogosawa, Shingo|Izutani, Yasuyuki|Nakamura, Yoshitaka|Watanabe, Hirotsuna|Sakai, Toshiyuki
PMID: 19937855
Journal: Lab Invest. 2010 Mar;90(3):496-505.
Title: Involvement of the IL-22/REG Ialpha axis in ulcerative colitis.
Author: Sekikawa, Akira|Fukui, Hirokazu|Suzuki, Katsumasa|Karibe, Toyohiko|Fujii, Shigehiko|Ichikawa, Kazuhito|Tomita, Shigeki|Imura, Johji|Shiratori, Keiko|Chiba, Tsutomu|Fujimori, Takahiro
PMID: 20065946
Journal: Oncogene. 2010 Jun 10;29(23):3313-23.
Title: Inflammatory bowel disease and intestinal cancer: a paradigm of the Yin-Yang interplay between inflammation and cancer.
Author: Danese, S|Mantovani, A
PMID: 20400974
Journal: Zhonghua Wei Chang Wai Ke Za Zhi. 2010 Apr;13(4):282-5.
Title: [Effect of JAK2/STAT3/vimentin signaling pathway on proliferation and migration of human colon cancer cells].
Author: Xu, Jian-hua|Zhang, Chao|Tang, Bo|Hao, Ying-xue|Chen, Jun|Liu, Tao|Cui, Hao
PMID: 20422486
Journal: Cancer Biol Ther. 2010 Aug 15;10(4):354-61. Epub 2010 Aug 18.
Title: Janus-activated kinases and signal transducer and activator of transcription control tumor growth response to camptothecin in human colon cancer cells.
Author: Yun, Hyun Jin|Kim, Sun Young|Kwon, Young Yon|Kim, Chun-Ho|Kang, Chang-Mo|Kim, Eun Ju
PMID: 20534983
Journal: Gastroenterology. 2010 Jul;139(1):353-5.
Title: STAT3 implicated in the development of colon cancer: a step closer for targeted therapy?
Author: Lau, George K K|Ye, Dewei
PMID: 20639089
Journal: J Mol Cell Biol. 2010 Aug;2(4):223-30.
Title: Association of Shp2 with phosphorylated IL-22R1 is required for interleukin-22-induced MAP kinase activation.
Author: Meng, Songshu|Gui, Qiu|Xu, Qing|Lu, Kaixin|Jiao, Xinan|Fan, Jian|Ge, Baoxue|Ke, Yuehai|Zhang, Shengping|Wu, Jie|Wang, Chuangui
PMID: 20671117
Journal: Curr Med Chem. 2010;17(29):3303-8.
Title: Anticancer properties of the IL-12 family--focus on colorectal cancer.
Author: Engel, M A|Neurath, M F
PMID: 20712574
Journal: Mol Cancer. 2010 Aug 16;9:217.
Title: A novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells.
Author: Lin, Li|Deangelis, Stephanie|Foust, Elizabeth|Fuchs, James|Li, Chenglong|Li, Pui-Kai|Schwartz, Eric B|Lesinski, Gregory B|Benson, Don|Lu, Jiagao|Hoyt, Dale|Lin, Jiayuh
PMID: 20712901
Journal: Cell Immunol. 2010;265(2):164-71.
Title: Neutralization of interleukin (IL)-10 released by monocytes/macrophages enhances the up-regulatory effect of monocyte/macrophage-derived IL-6 on expressions of IL-6 and MUC1, and migration in HT-29 colon cancer cells.
Author: Li, Ying-Ying|Chang, John W-C|Hsieh, Ling-Ling|Yeh, Kun-Yun
PMID: 20851386
Journal: J Clin Pathol. 2010 Oct;63(10):873-8.
Title: Prognostic value of phosphorylated STAT3 in advanced rectal cancer: a study from 104 French patients included in the EORTC 22921 trial.
Author: Monnien, Franck|Zaki, Harouna|Borg, Christophe|Mougin, Christiane|Bosset, Jean-Francois|Mercier, Mariette|Arbez-Gindre, Francine|Kantelip, Bernadette
PMID: 20876317
Journal: PLoS One. 2010 Sep 27;5(9):e13027.
Title: Toll-like receptor 2 signaling protects mice from tumor development in a mouse model of colitis-induced cancer.
Author: Lowe, Emily L|Crother, Timothy R|Rabizadeh, Shervin|Hu, Bing|Wang, Hanlin|Chen, Shuang|Shimada, Kenichi|Wong, Michelle H|Michelsen, Kathrin S|Arditi, Moshe
PMID: 20885960
Journal: Nutr Cancer. 2010;62(7):919-30.
Title: Curcumin, the golden spice from Indian saffron, is a chemosensitizer and radiosensitizer for tumors and chemoprotector and radioprotector for normal organs.
Author: Goel, Ajay|Aggarwal, Bharat B
PMID: 20924967
Journal: Int J Radiat Oncol Biol Phys. 2010 Nov 15;78(4):1184-92.
Title: A gene expression signature for chemoradiosensitivity of colorectal cancer cells.
Author: Spitzner, Melanie|Emons, Georg|Kramer, Frank|Gaedcke, Jochen|Rave-Frank, Margret|Scharf, Jens-Gerd|Burfeind, Peter|Becker, Heinz|Beissbarth, Tim|Ghadimi, B Michael|Ried, Thomas|Grade, Marian
PMID: 20970032
Journal: Dig Dis. 2010;28(4-5):590-5.
Title: Chronic inflammation, colorectal cancer and gene polymorphisms.
Author: Boland, C Richard
PMID: 21088407
Journal: J Exp Med. 2010 Dec 20;207(13):2855-68.
Title: VEGF receptor signaling links inflammation and tumorigenesis in colitis-associated cancer.
Author: Waldner, Maximilian J|Wirtz, Stefan|Jefremow, Andre|Warntjen, Moritz|Neufert, Clemens|Atreya, Raja|Becker, Christoph|Weigmann, Benno|Vieth, Michael|Rose-John, Stefan|Neurath, Markus F
PMID: 21098094
Journal: Inflamm Bowel Dis. 2011 May;17(5):1177-88.
Title: DMBT1 is a novel gene induced by IL-22 in ulcerative colitis.
Author: Fukui, Hirokazu|Sekikawa, Akira|Tanaka, Hiroyuki|Fujimori, Yukari|Katake, Yoshinori|Fujii, Shigehiko|Ichikawa, Kazuhito|Tomita, Shigeki|Imura, Johji|Chiba, Tsutomu|Fujimori, Takahiro
PMID: 20824812
Journal: J Cancer Res Clin Oncol. 2011 May;137(5):857-63.
Title: Cell-cell contacts induce STAT3 activity in colon carcinoma cells through an autocrine stimulation loop.
Author: Tsareva, Svetlana A|Wagner, Stefan|Muller, Annekatrin|Corvinus, Florian|Friedrich, Karlheinz
PMID: 20830487
Journal: Int J Colorectal Dis. 2011 Jan;26(1):13-22.
Title: Aspirin promotes apoptosis in a murine model of colorectal cancer by mechanisms involving downregulation of IL-6-STAT3 signaling pathway.
Author: Tian, Yun|Ye, Ying|Gao, Wei|Chen, Hong|Song, Ting|Wang, Daqing|Mao, Xiaoyun|Ren, Changshan
PMID: 20886344
Journal: Eur J Clin Invest. 2011 Mar;41(3):277-84.
Title: Anti-interleukin-6 receptor antibody inhibits the progression in human colon carcinoma cells.
Author: Hsu, Chih-Ping|Chen, Yung-Liang|Huang, Chiu-Chen|Chou, Chih-Chung|Liu, Chia-Ling|Hung, Chih-Hung|Kao, Ting-Yu|Chung, Yuan-Chiang
PMID: 21114487
Journal: Am J Clin Nutr. 2011 Feb;93(2):234-42.
Title: Diet-induced weight loss reduces colorectal inflammation: implications for colorectal carcinogenesis.
Author: Pendyala, Swaroop|Neff, Lisa M|Suarez-Farinas, Mayte|Holt, Peter R
PMID: 21147860
Journal: Biochim Biophys Acta. 2011 Feb;1813(2):308-14.
Title: Cytokine disbalance in common human cancers.
Author: Culig, Zoran
PMID: 21167870
Journal: Cancer Res. 2011 Mar 1;71(5):1615-26.
Title: Novel role for STAT3 in transcriptional regulation of NK immune cell targeting receptor MICA on cancer cells.
Author: Bedel, Romain|Thiery-Vuillemin, Antoine|Grandclement, Camille|Balland, Jeremy|Remy-Martin, Jean-Paul|Kantelip, Bernadette|Pallandre, Jean-Rene|Pivot, Xavier|Ferrand, Christophe|Tiberghien, Pierre|Borg, Christophe
PMID: 21257710
Journal: Clin Cancer Res. 2011 Mar 15;17(6):1452-62.
Title: STAT3 expression, molecular features, inflammation patterns, and prognosis in a database of 724 colorectal cancers.
Author: Morikawa, Teppei|Baba, Yoshifumi|Yamauchi, Mai|Kuchiba, Aya|Nosho, Katsuhiko|Shima, Kaori|Tanaka, Noriko|Huttenhower, Curtis|Frank, David A|Fuchs, Charles S|Ogino, Shuji
PMID: 21310826
Journal: Gut. 2011 Oct;60(10):1363-71.
Title: Leptin acts as a growth factor for colorectal tumours at stages subsequent to tumour initiation in murine colon carcinogenesis.
Author: Endo, Hiroki|Hosono, Kunihiro|Uchiyama, Takashi|Sakai, Eiji|Sugiyama, Michiko|Takahashi, Hirokazu|Nakajima, Noriko|Wada, Koichiro|Takeda, Kiyoshi|Nakagama, Hitoshi|Nakajima, Atsushi
PMID: 21406387
Journal: Biol Chem. 2011 May;392(5):449-59.
Title: STAT3 controls matrix metalloproteinase-1 expression in colon carcinoma cells by both direct and AP-1-mediated interaction with the MMP-1 promoter.
Author: Zugowski, Constance|Lieder, Franziska|Muller, Annekatrin|Gasch, Josephine|Corvinus, Florian M|Moriggl, Richard|Friedrich, Karlheinz
PMID: 21410405
Journal: Oncogene. 2011 Jul 28;30(30):3345-59.
Title: IL-32gamma inhibits cancer cell growth through inactivation of NF-kappaB and STAT3 signals.
Author: Oh, J H|Cho, M-C|Kim, J-H|Lee, S Y|Kim, H J|Park, E S|Ban, J O|Kang, J-W|Lee, D-H|Shim, J-H|Han, S B|Moon, D C|Park, Y H|Yu, D-Y|Kim, J-M|Kim, S H|Yoon, D-Y|Hong, J T
PMID: 21423208
Journal: Zhonghua Wei Chang Wai Ke Za Zhi. 2011 Mar;14(3):202-5.
Title: [Clinical significance of signal transduction and activators of transcription 3, E-cadherin and vimentin in colon cancer].
Author: Zhang, Chao|Xu, Jian-Hua|Liu, Tao|Cui, Hao
PMID: 21442485
Journal: BMC Cell Biol. 2011 Apr 12;12:14.
Title: A STAT3-decoy oligonucleotide induces cell death in a human colorectal carcinoma cell line by blocking nuclear transfer of STAT3 and STAT3-bound NF-kappaB.
Author: Souissi, Ines|Najjar, Imen|Ah-Koon, Laurent|Schischmanoff, Pierre Olivier|Lesage, Denis|Le Coquil, Stephanie|Roger, Claudine|Dusanter-Fourt, Isabelle|Varin-Blank, Nadine|Cao, An|Metelev, Valeri|Baran-Marszak, Fanny|Fagard, Remi
PMID: 21486470
Journal: J Clin Invest. 2011 May;121(5):1709-21.
Title: Heparanase powers a chronic inflammatory circuit that promotes colitis-associated tumorigenesis in mice.
Author: Lerner, Immanuel|Hermano, Esther|Zcharia, Eyal|Rodkin, Dina|Bulvik, Raanan|Doviner, Victoria|Rubinstein, Ariel M|Ishai-Michaeli, Rivka|Atzmon, Ruth|Sherman, Yoav|Meirovitz, Amichay|Peretz, Tamar|Vlodavsky, Israel|Elkin, Michael
PMID: 21490396
Journal: Zhonghua Zhong Liu Za Zhi. 2011 Feb;33(2):91-6.
Title: [Double suicide gene therapy with RNAi targeting to STAT3 inhibits the growth of colorectal carcinoma cells in vitro].
Author: Chen, Jian-yong|Luo, Bin|Guo, Xiao-bai|Wan, Li-hui
PMID: 21575474
Journal: Br J Cancer. 2011 Jul 12;105(2):212-20.
Title: Targeting colon cancer stem cells using a new curcumin analogue, GO-Y030.
Author: Lin, L|Liu, Y|Li, H|Li, P-K|Fuchs, J|Shibata, H|Iwabuchi, Y|Lin, J
PMID: 21694723
Journal: Gastroenterology. 2011 Sep;141(3):1046-56.
Title: Mesenchymal stem cells promote formation of colorectal tumors in mice.
Author: Tsai, Kuo-Shu|Yang, Shung-Haur|Lei, Yen-Ping|Tsai, Chih-Chien|Chen, Hsin-Wei|Hsu, Chih-Yuan|Chen, Ling-Lan|Wang, Hsei-Wei|Miller, Stephanie A|Chiou, Shih-Hwa|Hung, Mien-Chie|Hung, Shih-Chieh
PMID: 21699785
Journal: EMBO J. 2011 Jun 24;30(15):3186-99.
Title: Direct reprogramming of stem cell properties in colon cancer cells by CD44.
Author: Su, Ying-Jhen|Lai, Hsin-Mei|Chang, Yi-Wen|Chen, Guan-Ying|Lee, Jia-Lin
PMID: 21701559
Journal: Int J Oncol. 2011 Oct;39(4):935-40.
Title: Role of the long form leptin receptor and of the STAT3 signaling pathway in colorectal cancer progression.
Author: Uchiyama, Takashi|Takahashi, Hirokazu|Endo, Hiroki|Sugiyama, Michiko|Sakai, Eiji|Hosono, Kunihiro|Nagashima, Yoji|Inayama, Yoshiaki|Wada, Koichiro|Hippo, Yoshitaka|Nakajima, Atsushi
PMID: 21720710
Journal: Gastroenterology. 2011 Oct;141(4):1371-80, 1380.e1-2.
Title: Disruption of the mouse protein tyrosine kinase 6 gene prevents STAT3 activation and confers resistance to azoxymethane.
Author: Gierut, Jessica|Zheng, Yu|Bie, Wenjun|Carroll, Robert E|Ball-Kell, Susan|Haegebarth, Andrea|Tyner, Angela L
PMID: 21741923
Journal: PLoS One. 2011;6(7):e22538.
Title: STAT3 activation in skeletal muscle links muscle wasting and the acute phase response in cancer cachexia.
Author: Bonetto, Andrea|Aydogdu, Tufan|Kunzevitzky, Noelia|Guttridge, Denis C|Khuri, Sawsan|Koniaris, Leonidas G|Zimmers, Teresa A
PMID: 21799891
Journal: Mol Cancer Res. 2011 Oct;9(10):1418-28.
Title: Cross-talk between phospho-STAT3 and PLCgamma1 plays a critical role in colorectal tumorigenesis.
Author: Zhang, Peng|Zhao, Yiqing|Zhu, Xiaofeng|Sedwick, David|Zhang, Xiaodong|Wang, Zhenghe
PMID: 21840932
Journal: Cell Physiol Biochem. 2011;28(2):219-28.
Title: Resveratrol potentiates the cytotoxic oxidative stress induced by chemotherapy in human colon cancer cells.
Author: Santandreu, Francisca M|Valle, Adamo|Oliver, Jordi|Roca, Pilar
PMID: 21865729
Journal: Cancer Res. 2011 Dec 1;71(23):7226-37.
Title: STAT3 is necessary for proliferation and survival in colon cancer-initiating cells.
Author: Lin, Li|Liu, Aiguo|Peng, Zhengang|Lin, Huey-Jen|Li, Pui-Kai|Li, Chenglong|Lin, Jiayuh
PMID: 21900397
Journal: Cancer Microenviron. 2011 Aug;4(2):141-54.
Title: Tumor-associated Macrophages (TAM) and Inflammation in Colorectal Cancer.
Author: Erreni, Marco|Mantovani, Alberto|Allavena, Paola
PMID: 21909876
Journal: Gastroenterology. 2011 Dec;141(6):2154-65.
Title: Toll-like receptor 4 variant D299G induces features of neoplastic progression in Caco-2 intestinal cells and is associated with advanced human colon cancer.
Author: Eyking, Annette|Ey, Birgit|Runzi, Michael|Roig, Andres I|Reis, Henning|Schmid, Kurt W|Gerken, Guido|Podolsky, Daniel K|Cario, Elke
PMID: 21920464
Journal: Mol Cancer Res. 2011 Dec;9(12):1718-31.
Title: Cytokine induction of tumor necrosis factor receptor 2 is mediated by STAT3 in colon cancer cells.
Author: Hamilton, Kathryn E|Simmons, James G|Ding, Shengli|Van Landeghem, Laurianne|Lund, P Kay
PMID: 21994466
Journal: Braz J Med Biol Res. 2011 Dec;44(12):1222-30. Epub 2011 Oct 28.
Title: Inhibition of STAT3 by RNA interference suppresses angiogenesis in colorectal carcinoma.
Author: Qian, W F|Guan, W X|Gao, Y|Tan, J F|Qiao, Z M|Huang, H|Xia, C L
PMID: 22030865
Journal: Biochem Biophys Res Commun. 2011 Dec 16;416(3-4):246-51.
Title: STAT3 signaling pathway is necessary for cell survival and tumorsphere forming capacity in ALDH(+)/CD133(+) stem cell-like human colon cancer cells.
Author: Lin, Li|Fuchs, James|Li, Chenglong|Olson, Veronica|Bekaii-Saab, Tanios|Lin, Jiayuh
PMID: 22074823
Journal: Pharmacol Rep. 2011;63(5):1210-21.
Title: Chemopreventive effects of NSAIDs on cytokines and transcription factors during the early stages of colorectal cancer.
Author: Vaish, Vivek|Sanyal, Sankar N
PMID: 22180364
Journal: ISRN Endocrinol. 2011;2011:575397.
Title: Cellular signal transduction pathways by leptin in colorectal cancer tissue: preliminary results.
Author: Nowakowska-Zajdel, Ewa|Mazurek, Urszula|Stachowicz, Malgorzata|Niedworok, Elzbieta|Fatyga, Edyta|Muc-Wierzgon, Malgorzata
PMID: 22363883
Journal: Cancers (Basel). 2011 Jun 27;3(3):2811-26.
Title: Tumor Necrosis Factor (TNF) and Chemokines in Colitis-Associated Cancer.
Author: Mukaida, Naofumi|Sasakki, So-Ichiro|Popivanova, Boryana K
PMID: 24212934
Journal: Mol Carcinog. 2012 Feb;51(2):174-84.
Title: Trichostatin A, a histone deacetylase inhibitor, suppresses JAK2/STAT3 signaling via inducing the promoter-associated histone acetylation of SOCS1 and SOCS3 in human colorectal cancer cells.
Author: Xiong, Hua|Du, Wan|Zhang, Yan-Jie|Hong, Jie|Su, Wen-Yu|Tang, Jie-Ting|Wang, Ying-Chao|Lu, Rong|Fang, Jing-Yuan
PMID: 21520296
Journal: Mol Carcinog. 2012 Nov;51(11):869-80.
Title: A high-fat diet increases angiogenesis, solid tumor growth, and lung metastasis of CT26 colon cancer cells in obesity-resistant BALB/c mice.
Author: Park, Heesook|Kim, Minhee|Kwon, Gyoo Taik|Lim, Do Young|Yu, Rina|Sung, Mi-Kyung|Lee, Ki Won|Daily, James W 3rd|Park, Jung Han Yoon
PMID: 21919080
Journal: Am J Physiol Gastrointest Liver Physiol. 2012 Jan 1;302(1):G153-67.
Title: Immunomodulatory action of dietary fish oil and targeted deletion of intestinal epithelial cell PPARdelta in inflammation-induced colon carcinogenesis.
Author: Monk, Jennifer M|Kim, Wooki|Callaway, Evelyn|Turk, Harmony F|Foreman, Jennifer E|Peters, Jeffrey M|He, Weimin|Weeks, Brad|Alaniz, Robert C|McMurray, David N|Chapkin, Robert S
PMID: 21940900
Journal: Immunopharmacol Immunotoxicol. 2012 Jun;34(3):465-9.
Title: Induction of tolerogenic dendritic cells by IL-6-secreting CT26 colon carcinoma.
Author: Alshamsan, Aws
PMID: 21999714
Journal: Cancer Prev Res (Phila). 2012 Feb;5(2):205-15.
Title: Curcumin induces the differentiation of myeloid-derived suppressor cells and inhibits their interaction with cancer cells and related tumor growth.
Author: Tu, Shui Ping|Jin, Huanyu|Shi, Jin Dong|Zhu, Li Ming|Suo, Ya|Lu, Gang|Liu, Anna|Wang, Timothy C|Yang, Chung S
PMID: 22030090
Journal: J Cell Mol Med. 2012 Aug;16(8):1878-88.
Title: Inhibition of JAK2/STAT3 signalling induces colorectal cancer cell apoptosis via mitochondrial pathway.
Author: Du, Wan|Hong, Jie|Wang, Ying-Chao|Zhang, Yan-Jie|Wang, Ping|Su, Wen-Yu|Lin, Yan-Wei|Lu, Rong|Zou, Wei-Ping|Xiong, Hua|Fang, Jing-Yuan
PMID: 22050790
Journal: J Gastroenterol Hepatol. 2012 Jan;27(1):39-50.
Title: Colorectal cancer mouse models: integrating inflammation and the stroma.
Author: Ernst, Matthias|Ramsay, Robert G
PMID: 22188027
Journal: J Biol Chem. 2012 Feb 17;287(8):5819-32.
Title: Roles of STAT3 and ZEB1 proteins in E-cadherin down-regulation and human colorectal cancer epithelial-mesenchymal transition.
Author: Xiong, Hua|Hong, Jie|Du, Wan|Lin, Yan-wei|Ren, Lin-lin|Wang, Ying-chao|Su, Wen-yu|Wang, Ji-lin|Cui, Yun|Wang, Zhen-hua|Fang, Jing-Yuan
PMID: 22205702
Journal: Int J Oncol. 2012 May;40(5):1569-74.
Title: Pien Tze Huang inhibits tumor cell proliferation and promotes apoptosis via suppressing the STAT3 pathway in a colorectal cancer mouse model.
Author: Zhuang, Qunchuan|Hong, Fei|Shen, Aling|Zheng, Liangpu|Zeng, Jianwei|Lin, Wei|Chen, Youqin|Sferra, Thomas J|Hong, Zhenfeng|Peng, Jun
PMID: 22218594
Journal: J Gastroenterol. 2012 Feb;47(2):97-106.
Title: The inflammatory network in the gastrointestinal tumor microenvironment: lessons from mouse models.
Author: Oshima, Hiroko|Oshima, Masanobu
PMID: 22218775
Journal: Nanomedicine. 2012 Oct;8(7):1106-15.
Title: Electrostatic assembly of a DNA superparamagnetic nano-tool for simultaneous intracellular delivery and in situ monitoring.
Author: Geinguenaud, Frederic|Souissi, Ines|Fagard, Remi|Motte, Laurence|Lalatonne, Yoann
PMID: 22248815
Journal: Mol Cancer Ther. 2012 Apr;11(4):984-93.
Title: Therapeutic efficacy of CEP-33779, a novel selective JAK2 inhibitor, in a mouse model of colitis-induced colorectal cancer.
Author: Seavey, Matthew M|Lu, Lily D|Stump, Kristine L|Wallace, Nate H|Hockeimer, William|O'Kane, Teresa M|Ruggeri, Bruce A|Dobrzanski, Pawel
PMID: 22334590
Journal: Carcinogenesis. 2012 Apr;33(4):931-6.
Title: Role of IL-17A in the development of colitis-associated cancer.
Author: Hyun, Yil Sik|Han, Dong Soo|Lee, A Reum|Eun, Chang Soo|Youn, Jeehee|Kim, Ho-Youn
PMID: 22354874
Journal: Gut Liver. 2012 Jan;6(1):45-51.
Title: The Immunohistochemical Expression of STAT3, Bcl-xL, and MMP-2 Proteins in Colon Adenoma and Adenocarcinoma.
Author: Lee, Seung Woo|Ahn, Young Yong|Kim, Yon Soo|Kang, Sang Beum|Nam, Soon Woo|Lee, Dong Soo|Jeong, Hyun Yong|Kim, Jin Man
PMID: 22375170
Journal: Cancer Res. 2012 Apr 1;72(7):1705-16.
Title: Vanilloid receptor-1 regulates neurogenic inflammation in colon and protects mice from colon cancer.
Author: Vinuesa, Amaya G|Sancho, Rocio|Garcia-Limones, Carmen|Behrens, Axel|ten Dijke, Peter|Calzado, Marco A|Munoz, Eduardo
PMID: 22396497
Journal: J Clin Oncol. 2012 May 1;30(13):1505-12.
Title: Dual targeting of the epidermal growth factor receptor using the combination of cetuximab and erlotinib: preclinical evaluation and results of the phase II DUX study in chemotherapy-refractory, advanced colorectal cancer.
Author: Weickhardt, Andrew J|Price, Tim J|Chong, Geoff|Gebski, Val|Pavlakis, Nick|Johns, Terrance G|Azad, Arun|Skrinos, Effie|Fluck, Kate|Dobrovic, Alexander|Salemi, Renato|Scott, Andrew M|Mariadason, John M|Tebbutt, Niall C
PMID: 22412142
Journal: Mol Cancer. 2012 Mar 16;11:12.
Title: A STAT3-inhibitory hairpin decoy oligodeoxynucleotide discriminates between STAT1 and STAT3 and induces death in a human colon carcinoma cell line.
Author: Souissi, Ines|Ladam, Patrick|Cognet, Jean A H|Le Coquil, Stephanie|Varin-Blank, Nadine|Baran-Marszak, Fanny|Metelev, Valeri|Fagard, Remi
PMID: 22423663
Journal: Carcinogenesis. 2012 Jun;33(6):1231-8.
Title: Gut microbiota accelerate tumor growth via c-jun and STAT3 phosphorylation in APCMin/+ mice.
Author: Li, Yinghui|Kundu, Parag|Seow, Shih Wee|de Matos, Cristina Teixeira|Aronsson, Linda|Chin, Keh Chuang|Karre, Klas|Pettersson, Sven|Greicius, Gediminas
PMID: 22461519
Journal: J Biol Chem. 2012 May 25;287(22):18182-9.
Title: Signal transducer and activator of transcription 3 (STAT3) protein suppresses adenoma-to-carcinoma transition in Apcmin/+ mice via regulation of Snail-1 (SNAI) protein stability.
Author: Lee, Jongdae|Kim, Joanna C K|Lee, Shee-Eun|Quinley, Christine|Kim, HyeRi|Herdman, Scott|Corr, Maripat|Raz, Eyal
PMID: 22496368
Journal: J Biosci. 2012 Jun;37(2):243-57.
Title: STAT3 mutations correlated with hyper-IgE syndrome lead to blockage of IL-6/STAT3 signalling pathway.
Author: He, Jianxin|Shi, Jie|Xu, Ximing|Zhang, Wenhua|Wang, Yuxin|Chen, Xing|Du, Yuping|Zhu, Ning|Zhang, Jing|Wang, Qin|Yang, Jinbo
PMID: 22581330
Journal: Anticancer Agents Med Chem. 2012 Dec;12(10):1221-38.
Title: Prevention of colitis-associated cancer: natural compounds that target the IL-6 soluble receptor.
Author: Moriasi, Cate|Subramaniam, Dharmalingam|Awasthi, Shanjana|Ramalingam, Satish|Anant, Shrikant
PMID: 22583410
Journal: Carcinogenesis. 2012 Jul;33(7):1375-83.
Title: Dynamic activation of the key pathways: linking colitis to colorectal cancer in a mouse model.
Author: Tang, Anliu|Li, Nan|Li, Xiayu|Yang, Hongyuan|Wang, Wei|Zhang, Liyang|Li, Guiyuan|Xiong, Wei|Ma, Jian|Shen, Shourong
PMID: 22610167
Journal: PPAR Res. 2012;2012:269751.
Title: AS601245, an Anti-Inflammatory JNK Inhibitor, and Clofibrate Have a Synergistic Effect in Inducing Cell Responses and in Affecting the Gene Expression Profile in CaCo-2 Colon Cancer Cells.
Author: Cerbone, Angelo|Toaldo, Cristina|Pizzimenti, Stefania|Pettazzoni, Piergiorgio|Dianzani, Chiara|Minelli, Rosalba|Ciamporcero, Eric|Roma, Guglielmo|Dianzani, Mario Umberto|Canaparo, Roberto|Ferretti, Carlo|Barrera, Giuseppina
PMID: 22619672
Journal: Cancer Treat Rev. 2012 Nov;38(7):904-10.
Title: Interleukin-6 signaling pathway in targeted therapy for cancer.
Author: Guo, Yuqi|Xu, Feng|Lu, TianJian|Duan, Zhenfeng|Zhang, Zhan
PMID: 22651903
Journal: Br J Cancer. 2012 Jul 10;107(2):352-9.
Title: miR-21, miR-17 and miR-19a induced by phosphatase of regenerating liver-3 promote the proliferation and metastasis of colon cancer.
Author: Zhang, J|Xiao, Z|Lai, D|Sun, J|He, C|Chu, Z|Ye, H|Chen, S|Wang, J
PMID: 22677902
Journal: FEBS Lett. 2012 Sep 21;586(19):3013-7.
Title: STAT3 repressed USP7 expression is crucial for colon cancer development.
Author: Yang, Zhi|Huo, Shoujun|Shan, Yuanzhou|Liu, Haijun|Xu, Yume|Yao, Kai|Li, Xianwei|Zhang, Xueli
PMID: 22750444
Journal: Int J Mol Sci. 2012;13(5):6117-28.
Title: Hedyotis diffusa Willd inhibits colorectal cancer growth in vivo via inhibition of STAT3 signaling pathway.
Author: Cai, Qiaoyan|Lin, Jiumao|Wei, Lihui|Zhang, Ling|Wang, Lili|Zhan, Youzhi|Zeng, Jianwei|Xu, Wei|Shen, Aling|Hong, Zhenfeng|Peng, Jun
PMID: 22754353
Journal: Clin Cancer Res. 2012 Sep 15;18(18):4942-53.
Title: Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.
Author: Prasad, Sahdeo|Yadav, Vivek R|Sung, Bokyung|Reuter, Simone|Kannappan, Ramaswamy|Deorukhkar, Amit|Diagaradjane, Parmeswaran|Wei, Caimiao|Baladandayuthapani, Veerabhadran|Krishnan, Sunil|Guha, Sushovan|Aggarwal, Bharat B
PMID: 22832932
Journal: Cancer Res. 2012 Nov 15;72(22):5778-89.
Title: Prohibitin attenuates colitis-associated tumorigenesis in mice by modulating p53 and STAT3 apoptotic responses.
Author: Kathiria, Arwa S|Neumann, William L|Rhees, Jennifer|Hotchkiss, Erin|Cheng, Yulan|Genta, Robert M|Meltzer, Stephen J|Souza, Rhonda F|Theiss, Arianne L
PMID: 22869582
Journal: Genes Cancer. 2012 Jan;3(1):37-50.
Title: Targeting of Noncanonical Wnt5a Signaling by AP-1 Blocker Dominant-Negative Jun When It Inhibits Skin Carcinogenesis.
Author: Kang, Moon-Il|Baker, Alyson R|Dextras, Christopher R|Cabarcas, Stephanie M|Young, Matthew R|Colburn, Nancy H
PMID: 22893789
Journal: Cancer Cell. 2012 Sep 11;22(3):318-30.
Title: EGF receptor signaling is essential for k-ras oncogene-driven pancreatic ductal adenocarcinoma.
Author: Navas, Carolina|Hernandez-Porras, Isabel|Schuhmacher, Alberto J|Sibilia, Maria|Guerra, Carmen|Barbacid, Mariano
PMID: 22975375
Journal: Mol Cancer Ther. 2012 Nov;11(11):2311-20.
Title: Targeting protein tyrosine kinase 6 enhances apoptosis of colon cancer cells following DNA damage.
Author: Gierut, Jessica J|Mathur, Priya S|Bie, Wenjun|Han, Jin|Tyner, Angela L
PMID: 22989419
Journal: Oncol Rep. 2012 Dec;28(6):2125-30.
Title: Pien Tze Huang suppresses IL-6-inducible STAT3 activation in human colon carcinoma cells through induction of SOCS3.
Author: Shen, Aling|Chen, Youqin|Hong, Fei|Lin, Jiumao|Wei, Lihui|Hong, Zhenfeng|Sferra, Thomas J|Peng, Jun
PMID: 23027374
Journal: Antiinflamm Antiallergy Agents Med Chem. 2012;11(3):221-9.
Title: Interleukin-26, a highly cationic T-cell cytokine targeting epithelial cells.
Author: Braum, Oliver|Pirzer, Heide|Fickenscher, Helmut
PMID: 23106140
Journal: World J Surg Oncol. 2012 Oct 30;10:228.
Title: Inhibition of Jak-STAT3 pathway enhances bufalin-induced apoptosis in colon cancer SW620 cells.
Author: Zhu, Zhitu|Li, Enze|Liu, Yangyang|Gao, Yu|Sun, Hongzhi|Ma, Guangyou|Wang, Zhenghua|Liu, Xiaomei|Wang, Qingjun|Qu, Xiujuan|Liu, Yunpeng|Yu, Yunlong
PMID: 23110625
Journal: Mar Drugs. 2012 Sep;10(9):2055-68.
Title: In vivo induction of apoptosis by fucoxanthin, a marine carotenoid, associated with down-regulating STAT3/EGFR signaling in sarcoma 180 (S180) xenografts-bearing mice.
Author: Wang, Jun|Chen, Shihui|Xu, Shiqiang|Yu, Xing|Ma, Dongqing|Hu, Xiamin|Cao, Xiaolu
PMID: 23118721
Journal: Int J Biol Sci. 2012;8(9):1248-53.
Title: Interleukin-6--a key regulator of colorectal cancer development.
Author: Waldner, Maximilian J|Foersch, Sebastian|Neurath, Markus F
PMID: 23136553
Journal: PLoS One. 2012;7(11):e48342.
Title: Targeting COX-2/PGE(2) pathway in HIPK2 knockdown cancer cells: impact on dendritic cell maturation.
Author: Garufi, Alessia|Pistritto, Giuseppa|Ceci, Claudia|Di Renzo, Livia|Santarelli, Roberta|Faggioni, Alberto|Cirone, Mara|D'Orazi, Gabriella
PMID: 23144866
Journal: Cancer Cell. 2012 Nov 13;22(5):571-84.
Title: Dependency of colorectal cancer on a TGF-beta-driven program in stromal cells for metastasis initiation.
Author: Calon, Alexandre|Espinet, Elisa|Palomo-Ponce, Sergio|Tauriello, Daniele V F|Iglesias, Mar|Cespedes, Maria Virtudes|Sevillano, Marta|Nadal, Cristina|Jung, Peter|Zhang, Xiang H-F|Byrom, Daniel|Riera, Antoni|Rossell, David|Mangues, Ramon|Massague, Joan|Sanch
PMID: 23153532
Journal: Exp Ther Med. 2012 Oct;4(4):633-639.
Title: Relationship between expression and prognostic ability of PTEN, STAT3 and VEGF-C in colorectal cancer.
Author: Jin, Canhui|Wang, Aihong|Chen, Jianmin|Liu, Xiaomin|Wang, Gongping
PMID: 23170117
Journal: J BUON. 2012 Oct-Dec;17(4):691-4.
Title: Expression of pSTAT3 in human colorectal carcinoma: correlation with clinico-pathological parameters.
Author: Zizi-Sermpetzoglou, A|Savvaidou, V|Myoteri, D|Rizos, S|Marinis, A
PMID: 23335526
Journal: Am J Biomed Sci. 2012;4(1):14-25.
Title: Synthesis and Biological Evaluation of Novel N-phenyl-5-carboxamidyl Isoxazoles as Potential Chemotherapeutic Agents for Colon Cancer.
Author: Shaw, Jiajiu|Chen, Ben|Bourgault, Jean P|Jiang, Hao|Kumar, Narendra|Mishra, Jayshree|Valeriote, Frederick A|Media, Joe|Bobbitt, Kevin|Pietraszkiewicz, Halina|Edelstein, Matthew|Andreana, Peter R
PMID: 25285182
Journal: Horm Mol Biol Clin Investig. 2012 Jun;10(2):273-9.
Title: Inhibition of Stat3 by peptide aptamer rS3-PA enhances growth suppressive effects of irinotecan on colorectal cancer cells.
Author: Weber, Axel|Borghouts, Corina|Delis, Natalia|Mack, Laura|Brill, Boris|Bernard, Anne-Charlotte|Coqueret, Olivier|Groner, Bernd
PMID: 25436684
Journal: Mol Carcinog. 2013 Feb;52(2):155-66.
Title: JAK/STAT/SOCS-signaling pathway and colon and rectal cancer.
Author: Slattery, Martha L|Lundgreen, Abbie|Kadlubar, Susan A|Bondurant, Kristina L|Wolff, Roger K
PMID: 22121102
Journal: Gut. 2013 Apr;62(4):561-70.
Title: Salutary effects of adiponectin on colon cancer: in vivo and in vitro studies in mice.
Author: Moon, Hyun-Seuk|Liu, Xiaowen|Nagel, Jutta M|Chamberland, John P|Diakopoulos, Kalliope N|Brinkoetter, Mary T|Hatziapostolou, Maria|Wu, Yan|Robson, Simon C|Iliopoulos, Dimitrios|Mantzoros, Christos S
PMID: 22735569
Journal: J Mol Med (Berl). 2013 Apr;91(4):449-58.
Title: O-1602, an atypical cannabinoid, inhibits tumor growth in colitis-associated colon cancer through multiple mechanisms.
Author: Kargl, Julia|Haybaeck, Johannes|Stancic, Angela|Andersen, Liisa|Marsche, Gunther|Heinemann, Akos|Schicho, Rudolf
PMID: 22965195
Journal: Clin Colorectal Cancer. 2013 Mar;12(1):28-36.
Title: Impact of STAT3 phosphorylation on the clinical effectiveness of anti-EGFR-based therapy in patients with metastatic colorectal cancer.
Author: Dobi, Erion|Monnien, Franck|Kim, Stefano|Ivanaj, Arben|N'Guyen, Thiery|Demarchi, Martin|Adotevi, Olivier|Thierry-Vuillemin, Antoine|Jary, Marie|Kantelip, Bernadette|Pivot, Xavier|Godet, Yann|Degano, Severine Valmary|Borg, Christophe
PMID: 23083634
Journal: Cell Biochem Biophys. 2013 Jun;66(2):205-27.
Title: Angiostatic properties of sulindac and celecoxib in the experimentally induced inflammatory colorectal cancer.
Author: Vaish, Vivek|Piplani, Honit|Rana, Chandan|Sanyal, Sankar Nath
PMID: 23149858
Journal: Cancer Biol Ther. 2013 Feb;14(2):175-83.
Title: Histone deacetylase inhibitors induce CXCR4 mRNA but antagonize CXCR4 migration.
Author: Ierano, Caterina|Basseville, Agnes|To, Kenneth K W|Zhan, Zhirong|Robey, Robert W|Wilkerson, Julia|Bates, Susan E|Scala, Stefania
PMID: 23192271
Journal: Ann Rheum Dis. 2013 Apr;72 Suppl 2:ii100-3.
Title: Implications of anti-cytokine therapy in colorectal cancer and autoimmune diseases.
Author: Wang, Kepeng|Grivennikov, Sergei I|Karin, Michael
PMID: 23253923
Journal: Cancer Cell. 2013 Jan 14;23(1):107-20.
Title: Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer.
Author: Liang, Jie|Nagahashi, Masayuki|Kim, Eugene Y|Harikumar, Kuzhuvelil B|Yamada, Akimitsu|Huang, Wei-Ching|Hait, Nitai C|Allegood, Jeremy C|Price, Megan M|Avni, Dorit|Takabe, Kazuaki|Kordula, Tomasz|Milstien, Sheldon|Spiegel, Sarah
PMID: 23273921
Journal: Cancer Discov. 2013 Mar;3(3):294-307.
Title: Mutant N-RAS protects colorectal cancer cells from stress-induced apoptosis and contributes to cancer development and progression.
Author: Wang, Yufang|Velho, Sergia|Vakiani, Efsevia|Peng, Shouyong|Bass, Adam J|Chu, Gerald C|Gierut, Jessica|Bugni, James M|Der, Channing J|Philips, Mark|Solit, David B|Haigis, Kevin M
PMID: 23274911
Journal: Int J Oncol. 2013 Feb;42(2):651-6.
Title: Hedyotis diffusa Willd extract suppresses Sonic hedgehog signaling leading to the inhibition of colorectal cancer angiogenesis.
Author: Lin, Jiumao|Wei, Lihui|Shen, Aling|Cai, Qiaoyan|Xu, Wei|Li, Huang|Zhan, Youzhi|Hong, Zhenfeng|Peng, Jun
PMID: 23291612
Journal: J Clin Invest. 2013 Feb;123(2):767-81.
Title: mTORC1 inhibition restricts inflammation-associated gastrointestinal tumorigenesis in mice.
Author: Thiem, Stefan|Pierce, Thomas P|Palmieri, Michelle|Putoczki, Tracy L|Buchert, Michael|Preaudet, Adele|Farid, Ryan O|Love, Chris|Catimel, Bruno|Lei, Zhengdeng|Rozen, Steve|Gopalakrishnan, Veena|Schaper, Fred|Hallek, Michael|Boussioutas, Alex|Tan, Patrick|Ja
PMID: 23321674
Journal: Cancer Cell. 2013 Jan 14;23(1):5-7.
Title: Sphingosine 1-phosphate is a missing link between chronic inflammation and colon cancer.
Author: Pyne, Nigel J|Pyne, Susan
PMID: 23328479
Journal: Cancer Lett. 2013 Jun 1;333(1):56-65.
Title: Oct-4 is required for an antiapoptotic behavior of chemoresistant colorectal cancer cells enriched for cancer stem cells: effects associated with STAT3/Survivin.
Author: Wen, Kunming|Fu, Zhongxue|Wu, Xingye|Feng, Jihong|Chen, Wangsheng|Qian, Jiang
PMID: 23340171
Journal: Cell Oncol (Dordr). 2013 Apr;36(2):169-78.
Title: Abrogation of galectin-4 expression promotes tumorigenesis in colorectal cancer.
Author: Kim, Seung Won|Park, Ki Cheong|Jeon, Soung Min|Ohn, Tak Bum|Kim, Tae Il|Kim, Won Ho|Cheon, Jae Hee
PMID: 23378274
Journal: BMC Cancer. 2013 Feb 5;13:59.
Title: IL-22 is related to development of human colon cancer by activation of STAT3.
Author: Jiang, Runqiu|Wang, Haiyang|Deng, Lei|Hou, Jiajie|Shi, Ruihua|Yao, Ming|Gao, Yun|Yao, Aihua|Wang, Xuehao|Yu, Lianzhen|Sun, Beicheng
PMID: 23379788
Journal: J Pathol. 2013 Jul;230(3):277-90.
Title: Role of STAT3 and vitamin D receptor in EZH2-mediated invasion of human colorectal cancer.
Author: Lin, Yan-Wei|Ren, Lin-Lin|Xiong, Hua|Du, Wan|Yu, Ya-Nan|Sun, Tian-Tian|Weng, Yu-Rong|Wang, Zhen-Hua|Wang, Ji-Lin|Wang, Ying-Chao|Cui, Yun|Sun, Dan-Feng|Han, Ze-Guang|Shen, Nan|Zou, Weiping|Xu, Jie|Chen, Hao-Yan|Cao, Weibiao|Hong, Jie|Fang, Jing-Yuan
PMID: 23424038
Journal: Oncol Lett. 2013 Mar;5(3):756-760.
Title: Regulation of AKT gene expression by cisplatin.
Author: Zhang, Jun|Zhang, Ling-Li|Shen, Lei|Xu, Xi-Ming|Yu, Hong-Gang
PMID: 23426872
Journal: Eur J Cancer Prev. 2013 May;22(3):215-28.
Title: Role of cytokines and Jak3/Stat3 signaling in the 1,2-dimethylhydrazine dihydrochloride-induced rat model of colon carcinogenesis: early target in the anticancer strategy.
Author: Saini, Manpreet Kaur|Vaish, Vivek|Sanyal, Sankar Nath
PMID: 23514809
Journal: Peptides. 2013 Jun;44:127-34.
Title: Designer peptide antagonist of the leptin receptor with peripheral antineoplastic activity.
Author: Beccari, Serena|Kovalszky, Ilona|Wade, John D|Otvos, Laszlo Jr|Surmacz, Eva
PMID: 23567149
Journal: J Exp Med. 2013 May 6;210(5):917-31.
Title: Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model.
Author: Kirchberger, Stefanie|Royston, Daniel J|Boulard, Olivier|Thornton, Emily|Franchini, Fanny|Szabady, Rose L|Harrison, Oliver|Powrie, Fiona
PMID: 23589566
Journal: Carcinogenesis. 2013 Sep;34(9):2099-108.
Title: Myeloid TGF-beta signaling contributes to colitis-associated tumorigenesis in mice.
Author: Li, Jingyi|Liu, Yun|Wang, Boshi|Xu, Yingqian|Ma, Aihui|Zhang, Feng|Ge, Chao|Yang, Zhaojuan|Li, Jinjun|Liu, Yongzhong
PMID: 23695722
Journal: Cancer Sci. 2013 Sep;104(9):1139-45.
Title: Tying the knot between cytokine and toll-like receptor signaling in gastrointestinal tract cancers.
Author: Tye, Hazel|Jenkins, Brendan J
PMID: 23710764
Journal: Br J Cancer. 2013 Jul 9;109(1):138-46.
Title: Both STAT1 and STAT3 are favourable prognostic determinants in colorectal carcinoma.
Author: Gordziel, C|Bratsch, J|Moriggl, R|Knosel, T|Friedrich, K
PMID: 23756862
Journal: BMC Complement Altern Med. 2013 Jun 24;13:144.
Title: Spica prunellae promotes cancer cell apoptosis, inhibits cell proliferation and tumor angiogenesis in a mouse model of colorectal cancer via suppression of stat3 pathway.
Author: Lin, Wei|Zheng, Liangpu|Zhuang, Qunchuan|Zhao, Jinyan|Cao, Zhiyun|Zeng, Jianwei|Lin, Shan|Xu, Wei|Peng, Jun
PMID: 23800091
Journal: Asian Pac J Cancer Prev. 2013;14(5):2689-98.
Title: Epithelial-mesenchymal transition and its role in the pathogenesis of colorectal cancer.
Author: Zhu, Qing-Chao|Gao, Ren-Yuan|Wu, Wen|Qin, Huan-Long
PMID: 23803016
Journal: Neoplasia. 2013 Jul;15(7):783-94.
Title: Functional role and therapeutic potential of the pim-1 kinase in colon carcinoma.
Author: Weirauch, Ulrike|Beckmann, Nadine|Thomas, Maren|Grunweller, Arnold|Huber, Kilian|Bracher, Franz|Hartmann, Roland K|Aigner, Achim
PMID: 23814490
Journal: Inflamm Bowel Dis. 2013 Aug;19(9):1990-2000.
Title: Oroxylin A inhibits colitis-associated carcinogenesis through modulating the IL-6/STAT3 signaling pathway.
Author: Yang, Xi|Zhang, Fengyi|Wang, Yajing|Cai, Min|Wang, Qing|Guo, Qinglong|Li, Zhiyu|Hu, Rong
PMID: 23823704
Journal: Oncol Rep. 2013 Oct;30(4):1701-6.
Title: Pien Tze Huang inhibits tumor angiogenesis in a mouse model of colorectal cancer via suppression of multiple cellular pathways.
Author: Shen, Aling|Lin, Jiumao|Chen, Youqin|Lin, Wei|Liu, Liya|Hong, Zhenfeng|Sferra, Thomas J|Peng, Jun
PMID: 23843018
Journal: Cancer Cell Int. 2013 Jul 12;13(1):69.
Title: Inhibition of the angiogenesis and growth of Aloin in human colorectal cancer in vitro and in vivo.
Author: Pan, Qin|Pan, Hongming|Lou, Haizhou|Xu, Yinghua|Tian, Lu
PMID: 23848964
Journal: Int J Oncol. 2013 Oct;43(4):1235-43.
Title: Ursolic acid promotes colorectal cancer cell apoptosis and inhibits cell proliferation via modulation of multiple signaling pathways.
Author: Lin, Jiumao|Chen, Youqin|Wei, Lihui|Shen, Aling|Sferra, Thomas J|Hong, Zhenfeng|Peng, Jun
PMID: 23900560
Journal: Biochem Biophys Res Commun. 2013 Aug 30;438(3):513-8.
Title: JAB1 regulates unphosphorylated STAT3 DNA-binding activity through protein-protein interaction in human colon cancer cells.
Author: Nishimoto, Arata|Kugimiya, Naruji|Hosoyama, Toru|Enoki, Tadahiko|Li, Tao-Sheng|Hamano, Kimikazu
PMID: 23911788
Journal: PLoS One. 2013 Aug 5;8(8):e70300.
Title: MiR-124 suppresses growth of human colorectal cancer by inhibiting STAT3.
Author: Zhang, Jufeng|Lu, Yanxin|Yue, Xupeng|Li, Huiming|Luo, Xia|Wang, Ying|Wang, Kepeng|Wan, Jun
PMID: 23940556
Journal: Cell Commun Signal. 2013 Aug 15;11:59.
Title: Activation state-dependent interaction between Galphaq subunits and the Fhit tumor suppressor.
Author: Zuo, Hao|Chan, Grace P W|Zhu, Jing|Yeung, Wendy W S|Chan, Anthony S L|Ammer, Hermann|Wong, Yung H
PMID: 23947369
Journal: Neoplasia. 2013 Sep;15(9):998-1008.
Title: STAT3 in epithelial cells regulates inflammation and tumor progression to malignant state in colon.
Author: Nguyen, Andrew V|Wu, Yuan-Yuan|Liu, Qiang|Wang, Donghai|Nguyen, Stephanie|Loh, Ricky|Pang, Joey|Friedman, Kenneth|Orlofsky, Amos|Augenlicht, Leonard|Pollard, Jeffrey W|Lin, Elaine Y
PMID: 24027425
Journal: Int J Oncol. 2013 Nov;43(5):1666-74.
Title: Ursolic acid inhibits colorectal cancer angiogenesis through suppression of multiple signaling pathways.
Author: Lin, Jiumao|Chen, Youqin|Wei, Lihui|Hong, Zhenfeng|Sferra, Thomas J|Peng, Jun
PMID: 24042330
Journal: BMC Cancer. 2013 Oct 8;13:463.
Title: RKIP phosphorylation and STAT3 activation is inhibited by oxaliplatin and camptothecin and are associated with poor prognosis in stage II colon cancer patients.
Author: Cross-Knorr, Sam|Lu, Shaolei|Perez, Kimberly|Guevara, Sara|Brilliant, Kate|Pisano, Claudio|Quesenberry, Peter J|Resnick, Murray B|Chatterjee, Devasis
PMID: 24098947
Journal: Anticancer Agents Med Chem. 2013 Nov;13(9):1460-6.
Title: Discovery of P3971 an orally efficacious novel anticancer agent targeting HIF-1alpha and STAT3 pathways.
Author: Godse, Pallavi|Kumar, Pramod|Yewalkar, Nilambari|Deore, Vijaykumar|Lohar, Manoj|Mundada, Ramswaroop|Padgaonkar, Amol|Manohar, Sonal|Joshi, Asavari|Bhatia, Dimple|Desai, Nikesh|Damre, Anagha|Bhonde, Mandar|Joshi, Kalpana|Sharma, Rajiv|Kumar, Sanjay
PMID: 24102269
Journal: PLoS One. 2013 Oct 7;8(10):e77432.
Title: omega3-PUFAs exert anti-inflammatory activity in visceral adipocytes from colorectal cancer patients.
Author: D'Archivio, Massimo|Scazzocchio, Beatrice|Giammarioli, Stefania|Fiani, Maria L|Vari, Rosaria|Santangelo, Carmela|Veneziani, Augusto|Iacovelli, Annunziata|Giovannini, Claudio|Gessani, Sandra|Masella, Roberta
PMID: 24116229
Journal: Anticancer Res. 2013 Oct;33(10):4279-84.
Title: Ursolic acid inhibits the growth of colon cancer-initiating cells by targeting STAT3.
Author: Wang, Wenlong|Zhao, Chongqiang|Jou, David|Lu, Jiagao|Zhang, Cuntai|Lin, Li|Lin, Jiayuh
PMID: 24122993
Journal: Cancer Res. 2013 Dec 15;73(24):7211-21.
Title: TLR9 signaling in the tumor microenvironment initiates cancer recurrence after radiotherapy.
Author: Gao, Chan|Kozlowska, Anna|Nechaev, Sergey|Li, Haiqing|Zhang, Qifang|Hossain, Dewan M S|Kowolik, Claudia M|Chu, Peiguo|Swiderski, Piotr|Diamond, Don J|Pal, Sumanta K|Raubitschek, Andrew|Kortylewski, Marcin
PMID: 24154870
Journal: Endocr Relat Cancer. 2013 Oct 24;20(6):849-59.
Title: Adiponectin and metformin additively attenuate IL1beta-induced malignant potential of colon cancer.
Author: Moon, Hyun-Seuk|Mantzoros, Christos S
PMID: 24157941
Journal: BMC Cancer. 2013 Nov 8;13:531.
Title: Activation of pro-oncogenic pathways in colorectal hyperplastic polyps.
Author: Do, Catherine|Bertrand, Claudine|Palasse, Julien|Delisle, Marie-Bernadette|Cohen-Jonathan-Moyal, Elizabeth|Seva, Catherine
PMID: 24209454
Journal: PLoS One. 2013 Nov 6;8(11):e78850.
Title: Dietary iron enhances colonic inflammation and IL-6/IL-11-Stat3 signaling promoting colonic tumor development in mice.
Author: Chua, Anita C G|Klopcic, Borut R S|Ho, Desiree S|Fu, S Kristine|Forrest, Cynthia H|Croft, Kevin D|Olynyk, John K|Lawrance, Ian C|Trinder, Debbie
PMID: 24223168
Journal: Biol Open. 2013 Dec 15;2(12):1346-53.
Title: Characterization of the male ApcMin/+ mouse as a hypogonadism model related to cancer cachexia.
Author: White, James P|Puppa, Melissa J|Narsale, Aditi|Carson, James A
PMID: 24285707
Journal: Curr Colorectal Cancer Rep. 2013 Dec;9(4).
Title: Honokiol as a Radiosensitizing Agent for Colorectal cancers.
Author: He, Zhiyun|Subramaniam, Dharmalingam|Zhang, Zhongtao|Zhang, Youcheng|Anant, Shrikant
PMID: 24307888
Journal: Probiotics Antimicrob Proteins. 2013 Mar;5(1):51-8.
Title: In Vitro Investigation of the Immunomodulatory Potential of Probiotic Lactobacillus casei.
Author: Karthikeyan, Thirugnanam|Pravin, Mariappan|Muthusamy, Velusamy Shanmuganathan|Bharathi Raja, Rajaganapathy|Lakshmi, Baddireddi Subhadra
PMID: 26782605
Journal: Oncogene. 2014 Feb 13;33(7):851-61.
Title: PTTG acts as a STAT3 target gene for colorectal cancer cell growth and motility.
Author: Zhou, C|Tong, Y|Wawrowsky, K|Melmed, S
PMID: 23416975
Journal: Int J Cancer. 2014 Feb 15;134(4):997-1007.
Title: STAT3 inhibition sensitizes colorectal cancer to chemoradiotherapy in vitro and in vivo.
Author: Spitzner, Melanie|Roesler, Birte|Bielfeld, Christian|Emons, Georg|Gaedcke, Jochen|Wolff, Hendrik A|Rave-Frank, Margret|Kramer, Frank|Beissbarth, Tim|Kitz, Julia|Wienands, Jurgen|Ghadimi, B Michael|Ebner, Reinhard|Ried, Thomas|Grade, Marian
PMID: 23934972
Journal: Cancer Lett. 2014 Feb 1;343(1):80-9.
Title: Bone marrow-derived myofibroblasts promote colon tumorigenesis through the IL-6/JAK2/STAT3 pathway.
Author: Zhu, Liming|Cheng, Xiaojiao|Ding, Yanfei|Shi, Jindong|Jin, Huanyu|Wang, Hong|Wu, Yunlin|Ye, Jing|Lu, Yiming|Wang, Timothy C|Yang, Chung S|Tu, Shui Ping
PMID: 24145153
Journal: Adv Biol Regul. 2014 Jan;54:112-20.
Title: Sphingosine-1-phosphate in chronic intestinal inflammation and cancer.
Author: Nagahashi, Masayuki|Hait, Nitai C|Maceyka, Michael|Avni, Dorit|Takabe, Kazuaki|Milstien, Sheldon|Spiegel, Sarah
PMID: 24210073
Journal: Apoptosis. 2014 Feb;19(2):298-305.
Title: Transcription control of DAPK.
Author: Benderska, Natalya|Schneider-Stock, Regine
PMID: 24217921
Journal: Integr Cancer Ther. 2014 May;13(3):240-8.
Title: Scutellaria Barbata D Don Inhibits Colorectal Cancer Growth via Suppression of Multiple Signaling Pathways.
Author: Lin, Jiumao|Chen, Youqin|Cai, Qiaoyan|Wei, Lihui|Zhan, Youzhi|Shen, Aling|Sferra, Thomas J|Peng, Jun
PMID: 24231788
Journal: Carcinogenesis. 2014 Apr;35(4):795-806.
Title: Prolactin signaling enhances colon cancer stemness by modulating Notch signaling in a Jak2-STAT3/ERK manner.
Author: Neradugomma, Naveen K|Subramaniam, Dharmalingam|Tawfik, Ossama W|Goffin, Vincent|Kumar, T Rajendra|Jensen, Roy A|Anant, Shrikant
PMID: 24265293
Journal: Eur J Cardiothorac Surg. 2014 Jul;46(1):92-9.
Title: Carbonic anhydrase IX is associated with early pulmonary spreading of primary colorectal carcinoma and tobacco smoking.
Author: Schweiger, Thomas|Kollmann, Dagmar|Nikolowsky, Christoph|Traxler, Denise|Guenova, Emmanuella|Lang, Gyorgy|Birner, Peter|Klepetko, Walter|Ankersmit, Hendrik Jan|Hoetzenecker, Konrad
PMID: 24321995
Journal: Int J Oncol. 2014 Apr;44(4):1032-40.
Title: The IL-6/JAK/STAT3 pathway: potential therapeutic strategies in treating colorectal cancer (Review).
Author: Wang, Shu-Wei|Sun, Yue-Ming
PMID: 24430672
Journal: J Nutr Biochem. 2014 Feb;25(2):186-92.
Title: Feeding with olive oil attenuates inflammation in dextran sulfate sodium-induced colitis in rat.
Author: Takashima, Toru|Sakata, Yasuhisa|Iwakiri, Ryuichi|Shiraishi, Ryosuke|Oda, Yasutomo|Inoue, Norie|Nakayama, Atsushi|Toda, Shuji|Fujimoto, Kazuma
PMID: 24445043
Journal: Semin Immunol. 2014 Feb;26(1):75-9.
Title: Master regulator of intestinal disease: IL-6 in chronic inflammation and cancer development.
Author: Waldner, Maximilian J|Neurath, Markus F
PMID: 24447345
Journal: J Phys Chem B. 2014 Feb 13;118(6):1535-44.
Title: Easily controlled grafting of oligonucleotides on gammaFe2O3 nanoparticles: physicochemical characterization of DNA organization and biological activity studies.
Author: Geinguenaud, Frederic|Souissi, Ines|Fagard, Remi|Lalatonne, Yoann|Motte, Laurence
PMID: 24467641
Journal: Int J Oncol. 2014 Apr;44(4):1309-15.
Title: Carnosol induces apoptosis through generation of ROS and inactivation of STAT3 signaling in human colon cancer HCT116 cells.
Author: Park, Ki-Woong|Kundu, Juthika|Chae, In-Gyeong|Kim, Do-Hee|Yu, Mi-Hee|Kundu, Joydeb Kumar|Chun, Kyung-Soo
PMID: 24481553
Journal: Cell Death Dis. 2014 Feb 6;5:e1046.
Title: Fibroblast growth factor receptor 4 (FGFR4): a targetable regulator of drug resistance in colorectal cancer.
Author: Turkington, R C|Longley, D B|Allen, W L|Stevenson, L|McLaughlin, K|Dunne, P D|Blayney, J K|Salto-Tellez, M|Van Schaeybroeck, S|Johnston, P G
PMID: 24503538
Journal: Cancer Res. 2014 Apr 1;74(7):2062-72.
Title: Novel mechanistic insights into ectodomain shedding of EGFR Ligands Amphiregulin and TGF-alpha: impact on gastrointestinal cancers driven by secondary bile acids.
Author: Nagathihalli, Nagaraj S|Beesetty, Yugandhar|Lee, Wooin|Washington, M Kay|Chen, Xi|Lockhart, A Craig|Merchant, Nipun B
PMID: 24520077
Journal: Cancer Biol Ther. 2014 May;15(5):623-32.
Title: Anti-EGFR therapeutic efficacy correlates directly with inhibition of STAT3 activity.
Author: Ung, Nelson|Putoczki, Tracy L|Stylli, Stanley S|Ng, Irvin|Mariadason, John M|Chan, Timothy A|Zhu, Hong-Jian|Luwor, Rodney B
PMID: 24556630
Journal: Asian Pac J Cancer Prev. 2014;15(2):551-60.
Title: Signal transducer and activator of transcription 3 - a promising target in colitis-associated cancer.
Author: Pandurangan, Ashok Kumar|Esa, Norhaizan Mohd
PMID: 24568457
Journal: J Clin Invest. 2014 Apr;124(4):1853-67.
Title: IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis.
Author: Rokavec, Matjaz|Oner, Meryem Gulfem|Li, Huihui|Jackstadt, Rene|Jiang, Longchang|Lodygin, Dmitri|Kaller, Markus|Horst, David|Ziegler, Paul K|Schwitalla, Sarah|Slotta-Huspenina, Julia|Bader, Franz G|Greten, Florian R|Hermeking, Heiko
PMID: 24642471
Journal: Mol Cancer Ther. 2014 May;13(5):1206-16.
Title: Embelin reduces colitis-associated tumorigenesis through limiting IL-6/STAT3 signaling.
Author: Dai, Yun|Jiao, Hongmei|Teng, Guigen|Wang, Weihong|Zhang, Rongxin|Wang, Yunhong|Hebbard, Lionel|George, Jacob|Qiao, Liang
PMID: 24651526
Journal: PLoS One. 2014 Mar 25;9(3):e92966.
Title: Depletion of white adipose tissue in cancer cachexia syndrome is associated with inflammatory signaling and disrupted circadian regulation.
Author: Tsoli, Maria|Schweiger, Martina|Vanniasinghe, Anne S|Painter, Arran|Zechner, Rudolf|Clarke, Stephen|Robertson, Graham
PMID: 24667661
Journal: Int J Mol Med. 2014 Jun;33(6):1613-20.
Title: Aloperine induces G2/M phase cell cycle arrest and apoptosis in HCT116 human colon cancer cells.
Author: Zhang, Li|Zheng, Yanxin|Deng, Hongzhu|Liang, Lei|Peng, Juan
PMID: 24682388
Journal: Cell Signal. 2014 Sep;26(9):1853-62.
Title: Pyruvate kinase M2 facilitates colon cancer cell migration via the modulation of STAT3 signalling.
Author: Yang, Peng|Li, Zongwei|Fu, Rong|Wu, Haili|Li, Zhuoyu
PMID: 24686087
Journal: Int J Oncol. 2014 Jun;44(6):2077-84.
Title: HIF-1alpha activation under glucose deprivation plays a central role in the acquisition of anti-apoptosis in human colon cancer cells.
Author: Nishimoto, Arata|Kugimiya, Naruji|Hosoyama, Tohru|Enoki, Tadahiko|Li, Tao-Sheng|Hamano, Kimikazu
PMID: 24718784
Journal: EMBO J. 2014 Jul 1;33(13):1474-91.
Title: c-Src drives intestinal regeneration and transformation.
Author: Cordero, Julia B|Ridgway, Rachel A|Valeri, Nicola|Nixon, Colin|Frame, Margaret C|Muller, William J|Vidal, Marcos|Sansom, Owen J
PMID: 24788409
Journal: Immunity. 2014 May 15;40(5):772-84.
Title: IL-22(+)CD4(+) T cells promote colorectal cancer stemness via STAT3 transcription factor activation and induction of the methyltransferase DOT1L.
Author: Kryczek, Ilona|Lin, Yanwei|Nagarsheth, Nisha|Peng, Dongjun|Zhao, Lili|Zhao, Ende|Vatan, Linda|Szeliga, Wojciech|Dou, Yali|Owens, Scott|Zgodzinski, Witold|Majewski, Marek|Wallner, Grzegorz|Fang, Jingyuan|Huang, Emina|Zou, Weiping
PMID: 24816405
Journal: Immunity. 2014 May 15;40(5):639-41.
Title: IL-22 gets to the stem of colorectal cancer.
Author: Koltsova, Ekaterina K|Grivennikov, Sergei I
PMID: 24837100
Journal: J Clin Invest. 2014 Jun;124(6):2472-82.
Title: Synthetic triterpenoid induces 15-PGDH expression and suppresses inflammation-driven colon carcinogenesis.
Author: Choi, Sung Hee|Kim, Byung-Gyu|Robinson, Janet|Fink, Steve|Yan, Min|Sporn, Michael B|Markowitz, Sanford D|Letterio, John J
PMID: 24837432
Journal: Oncol Rep. 2014 Aug;32(2):821-8.
Title: Thymoquinone induces apoptosis in human colon cancer HCT116 cells through inactivation of STAT3 by blocking JAK2- and Srcmediated phosphorylation of EGF receptor tyrosine kinase.
Author: Kundu, Juthika|Choi, Bu Young|Jeong, Chul-Ho|Kundu, Joydeb Kumar|Chun, Kyung-Soo
PMID: 24890449
Journal: Gastroenterology. 2014 Oct;147(4):847-859.e11.
Title: A microRNA 221- and 222-mediated feedback loop maintains constitutive activation of NFkappaB and STAT3 in colorectal cancer cells.
Author: Liu, Sanhong|Sun, Xiaohua|Wang, Mingliang|Hou, Yingyong|Zhan, Yu|Jiang, Yuhang|Liu, Zhanjie|Cao, Xinwei|Chen, Pengfei|Liu, Zhi|Chen, Xi|Tao, Yu|Xu, Chen|Mao, Jie|Cheng, Chunyan|Li, Cuifeng|Hu, Yiming|Wang, Lunshan|Chin, Y Eugene|Shi, Yufang|Siebenlist, Ul
PMID: 24931456
Journal: Cell Rep. 2014 Jun 26;7(6):1940-55.
Title: ADAM17-dependent c-MET-STAT3 signaling mediates resistance to MEK inhibitors in KRAS mutant colorectal cancer.
Author: Van Schaeybroeck, Sandra|Kalimutho, Murugan|Dunne, Philip D|Carson, Robbie|Allen, Wendy|Jithesh, Puthen V|Redmond, Keara L|Sasazuki, Takehiko|Shirasawa, Senji|Blayney, Jaine|Michieli, Paolo|Fenning, Cathy|Lenz, Heinz-Josef|Lawler, Mark|Longley, Daniel B|J
PMID: 24931611
Journal: Zhonghua Wei Chang Wai Ke Za Zhi. 2014 Jun;17(6):594-7.
Title: [Expressions of STAT3, p-STAT3 and E-cadherin in colorectal cancer and clinical implications].
Author: Zhong, Baoyuan|Liu, Qingquan|Liu, Yanxiu|Xiong, Xiaoliang|Liu, Yao
PMID: 24953370
Journal: Carcinogenesis. 2014 Sep;35(9):2134-41.
Title: Conditional knockout of the leptin receptor in the colonic epithelium revealed the local effects of leptin receptor signaling in the progression of colonic tumors in mice.
Author: Higurashi, Takuma|Endo, Hiroki|Uchiyama, Takashi|Uchiyama, Shiori|Yamada, Eiji|Ohkubo, Hidenori|Sakai, Eiji|Takahashi, Hirokazu|Maeda, Shin|Wada, Koichiro|Natsumeda, Yutaka|Hippo, Yoshitaka|Nakajima, Atsushi|Nakagama, Hitoshi
PMID: 24958593
Journal: Cell Physiol Biochem. 2014;33(6):1863-75.
Title: Ubiquitin-specific peptidase USP22 negatively regulates the STAT signaling pathway by deubiquitinating SIRT1.
Author: Ao, Ning|Liu, Yanyan|Feng, Hailiang|Bian, Xiaocui|Li, Zhanwen|Gu, Bei|Zhao, Xiaomei|Liu, Yuqin
PMID: 24969755
Journal: Cancers (Basel). 2014 Jul 3;6(3):1394-407.
Title: STAT3: An Anti-Invasive Factor in Colorectal Cancer?
Author: de Jong, Petrus Rudolf|Mo, Ji-Hun|Harris, Alexandra R|Lee, Jongdae|Raz, Eyal
PMID: 24995503
Journal: Biochem Biophys Res Commun. 2014 Aug 8;450(4):1402-8.
Title: Bone marrow mesenchymal stem cells ameliorate colitis-associated tumorigenesis in mice.
Author: Chen, Zexian|He, Xiaowen|He, Xiaosheng|Chen, Xiuting|Lin, Xutao|Zou, Yifeng|Wu, Xiaojian|Lan, Ping
PMID: 25010644
Journal: Endocr Relat Cancer. 2014 Aug;21(4):639-51.
Title: The role of corticotropin-releasing hormone receptor 1 in the development of colitis-associated cancer in mouse model.
Author: Liu, Yunxin|Fang, Xianjun|Yuan, Jie|Sun, Zongxing|Li, Chuanhua|Li, Rong|Li, Li|Zhu, Chao|Wan, Rong|Guo, Rui|Jin, Lai|Li, Shengnan
PMID: 25015995
Journal: Toxicol Appl Pharmacol. 2014 Sep 15;279(3):311-21.
Title: Isoliquiritigenin, a flavonoid from licorice, blocks M2 macrophage polarization in colitis-associated tumorigenesis through downregulating PGE2 and IL-6.
Author: Zhao, Haixia|Zhang, Xinhua|Chen, Xuewei|Li, Ying|Ke, Zunqiong|Tang, Tian|Chai, Hongyan|Guo, Austin M|Chen, Honglei|Yang, Jing
PMID: 25026504
Journal: Clin Immunol. 2014 Oct;154(2):116-26.
Title: Interleukin 22 protects colorectal cancer cells from chemotherapy by activating the STAT3 pathway and inducing autocrine expression of interleukin 8.
Author: Wu, Tingyu|Wang, Zhongchuan|Liu, Yun|Mei, Zubing|Wang, Guanghui|Liang, Zhonglin|Cui, Ang|Hu, Xuguang|Cui, Long|Yang, Yili|Liu, Chen-Ying
PMID: 25063444
Journal: Zhonghua Wei Chang Wai Ke Za Zhi. 2014 Jul;17(7):706-10.
Title: [Inflammation promotes the development of colitis-associated colorectal cancer].
Author: He, Zhen|Ke, Jia|He, Xiaowen|Lian, Lei|Sun, Lei|Chen, Zexian|Wu, Xiaojian|Lan, Ping
PMID: 25070454
Journal: Oncotarget. 2014 Aug 15;5(15):6243-51.
Title: SHP-1 is a target of regorafenib in colorectal cancer.
Author: Fan, Li-Ching|Teng, Hao-Wei|Shiau, Chung-Wai|Lin, Hang|Hung, Man-Hsin|Chen, Yen-Lin|Huang, Jui-Wen|Tai, Wei-Tien|Yu, Hui-Chuan|Chen, Kuen-Feng
PMID: 25071018
Journal: Free Radic Res. 2014 Nov;48(11):1311-21.
Title: Generation of ROS by CAY10598 leads to inactivation of STAT3 signaling and induction of apoptosis in human colon cancer HCT116 cells.
Author: Chae, I G|Kim, D-H|Kundu, J|Jeong, C-H|Kundu, J K|Chun, K-S
PMID: 25096910
Journal: Biomed Res Int. 2014;2014:187105.
Title: Genome-wide uncovering of STAT3-mediated miRNA expression profiles in colorectal cancer cell lines.
Author: Zhang, Jufeng|Luo, Xia|Li, Huiming|Deng, Ling|Wang, Ying
PMID: 25126546
Journal: Cancer Epidemiol. 2014 Oct;38(5):583-90.
Title: An analysis of genetic factors related to risk of inflammatory bowel disease and colon cancer.
Author: Ryan, Brid M|Wolff, Roger K|Valeri, Nicola|Khan, Mohammed|Robinson, Dillon|Paone, Alessio|Bowman, Elise D|Lundgreen, Abbie|Caan, Bette|Potter, John|Brown, Derek|Croce, Carlo|Slattery, Martha L|Harris, Curtis C
PMID: 25132422
Journal: World J Gastroenterol. 2014 Aug 14;20(30):10279-87.
Title: STAT3 and sphingosine-1-phosphate in inflammation-associated colorectal cancer.
Author: Nguyen, Andrew V|Wu, Yuan-Yuan|Lin, Elaine Y
PMID: 25132744
Journal: PLoS One. 2014 Aug 28;9(8):e105991.
Title: Tumor suppressor microRNA-27a in colorectal carcinogenesis and progression by targeting SGPP1 and Smad2.
Author: Bao, Yonghua|Chen, Zhiguo|Guo, Yongchen|Feng, Yansheng|Li, Zexin|Han, Wenliang|Wang, Jianguo|Zhao, Weixing|Jiao, Yunjuan|Li, Kai|Wang, Qian|Wang, Jiaqi|Zhang, Huijuan|Wang, Liang|Yang, Wancai
PMID: 25166914
Journal: Oncol Rep. 2014 Nov;32(5):1873-80.
Title: Activation of the mTORC1 and STAT3 pathways promotes the malignant transformation of colitis in mice.
Author: He, Zhen|He, Xiaosheng|Chen, Zexian|Ke, Jia|He, Xiaowen|Yuan, Ruixue|Cai, Zerong|Chen, Xiuting|Wu, Xiaojian|Lan, Ping
PMID: 25174408
Journal: Inflamm Bowel Dis. 2014 Dec;20(12):2405-11.
Title: Stat3: friend or foe in colitis and colitis-associated cancer?
Author: Han, Jie|Theiss, Arianne L
PMID: 25185686
Journal: Oncol Rep. 2014 Nov;32(5):1991-8.
Title: AZD1480, a JAK inhibitor, inhibits cell growth and survival of colorectal cancer via modulating the JAK2/STAT3 signaling pathway.
Author: Wang, Shu-Wei|Hu, Jun|Guo, Qin-Hao|Zhao, Yan|Cheng, Jie-Jing|Zhang, Dong-Sheng|Fei, Qiang|Li, Juan|Sun, Yue-Ming
PMID: 25216185
Journal: Am J Cancer Res. 2014 Sep 6;4(5):484-94. eCollection 2014.
Title: STAT3beta controls inflammatory responses and early tumor onset in skin and colon experimental cancer models.
Author: Marino, Francesca|Orecchia, Valeria|Regis, Gabriella|Musteanu, Monica|Tassone, Beatrice|Jon, Cristina|Forni, Marco|Calautti, Enzo|Chiarle, Roberto|Eferl, Robert|Poli, Valeria
PMID: 25232490
Journal: Cancer Res. 2014 Nov 1;74(21):6341-51.
Title: Holo-retinol-binding protein and its receptor STRA6 drive oncogenic transformation.
Author: Berry, Daniel C|Levi, Liraz|Noy, Noa
PMID: 25237067
Journal: Am J Physiol Gastrointest Liver Physiol. 2014 Nov 15;307(10):G968-78.
Title: Nicotine suppresses acute colitis and colonic tumorigenesis associated with chronic colitis in mice.
Author: Hayashi, Shusaku|Hamada, Takayuki|Zaidi, Syed Faisal|Oshiro, Momoe|Lee, Jaemin|Yamamoto, Takeshi|Ishii, Yoko|Sasahara, Masakiyo|Kadowaki, Makoto
PMID: 25258409
Journal: Sci Signal. 2014 Sep 30;7(345):ra92.
Title: Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt-beta-catenin-mediated intestinal tumor growth and regeneration.
Author: Phesse, Toby J|Buchert, Michael|Stuart, Emma|Flanagan, Dustin J|Faux, Maree|Afshar-Sterle, Shoukat|Walker, Francesca|Zhang, Hui-Hua|Nowell, Cameron J|Jorissen, Robert|Tan, Chin Wee|Hirokawa, Yumiko|Eissmann, Moritz F|Poh, Ashleigh R|Malaterre, Jordane|Pea
PMID: 25270258
Journal: J Immunol. 2014 Nov 15;193(10):4779-82.
Title: Cutting edge: STING mediates protection against colorectal tumorigenesis by governing the magnitude of intestinal inflammation.
Author: Zhu, Qifan|Man, Si Ming|Gurung, Prajwal|Liu, Zhiping|Vogel, Peter|Lamkanfi, Mohamed|Kanneganti, Thirumala-Devi
PMID: 25320273
Journal: Cell Death Dis. 2014 Oct 16;5:e1476.
Title: HDAC8 and STAT3 repress BMF gene activity in colon cancer cells.
Author: Kang, Y|Nian, H|Rajendran, P|Kim, E|Dashwood, W M|Pinto, J T|Boardman, L A|Thibodeau, S N|Limburg, P J|Lohr, C V|Bisson, W H|Williams, D E|Ho, E|Dashwood, R H
PMID: 25321483
Journal: Nat Commun. 2014 Oct 17;5:5218.
Title: LIF negatively regulates tumour-suppressor p53 through Stat3/ID1/MDM2 in colorectal cancers.
Author: Yu, Haiyang|Yue, Xuetian|Zhao, Yuhan|Li, Xiaoyan|Wu, Lihua|Zhang, Cen|Liu, Zhen|Lin, Kevin|Xu-Monette, Zijun Y|Young, Ken H|Liu, Juan|Shen, Zhiyuan|Feng, Zhaohui|Hu, Wenwei
PMID: 25323535
Journal: Br J Cancer. 2014 Dec 9;111(12):2287-96.
Title: Interleukin-6 mediated upregulation of CYP1B1 and CYP2E1 in colorectal cancer involves DNA methylation, miR27b and STAT3.
Author: Patel, S A A|Bhambra, U|Charalambous, M P|David, R M|Edwards, R J|Lightfoot, T|Boobis, A R|Gooderham, N J
PMID: 25333344
Journal: J Clin Invest. 2014 Dec;124(12):5368-84.
Title: Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3-activated microRNAs.
Author: Degagne, Emilie|Pandurangan, Ashok|Bandhuvula, Padmavathi|Kumar, Ashok|Eltanawy, Abeer|Zhang, Meng|Yoshinaga, Yuko|Nefedov, Mikhail|de Jong, Pieter J|Fong, Loren G|Young, Stephen G|Bittman, Robert|Ahmedi, Yasmin|Saba, Julie D
PMID: 25347472
Journal: Int J Exp Pathol. 2014 Dec;95(6):392-400.
Title: STAT3 paradoxically stimulates beta-catenin expression but inhibits beta-catenin function.
Author: Ibrahem, Salih|Al-Ghamdi, Saleh|Baloch, Kanwal|Muhammad, Belal|Fadhil, Wakkas|Jackson, Darryl|Nateri, Abdolrahman S|Ilyas, Mohammad
PMID: 25348333
Journal: Cell. 2014 Nov 6;159(4):844-56.
Title: A noncanonical Frizzled2 pathway regulates epithelial-mesenchymal transition and metastasis.
Author: Gujral, Taranjit S|Chan, Marina|Peshkin, Leonid|Sorger, Peter K|Kirschner, Marc W|MacBeath, Gavin
PMID: 25417160
Journal: J Immunother Cancer. 2014 Nov 18;2(1):38.
Title: Detailed characterization of tumor infiltrating lymphocytes in two distinct human solid malignancies show phenotypic similarities.
Author: Kovacsovics-Bankowski, Magdalena|Chisholm, Lana|Vercellini, Jonna|Tucker, Christopher G|Montler, Ryan|Haley, Daniel|Newell, Philippa|Ma, Jun|Tseng, Paul|Wolf, Ronald|Vetto, John T|Hammill, Chet|Hansen, Paul|Weinberg, Andrew D
PMID: 25436113
Journal: PLoS One. 2014 Dec 1;9(12):e113931.
Title: Distinct behaviour of sorafenib in experimental cachexia-inducing tumours: the role of STAT3.
Author: Toledo, Miriam|Penna, Fabio|Busquets, Silvia|Lopez-Soriano, Francisco J|Argiles, Josep M
PMID: 25436606
Journal: Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):18321-6.
Title: Microbiota organization is a distinct feature of proximal colorectal cancers.
Author: Dejea, Christine M|Wick, Elizabeth C|Hechenbleikner, Elizabeth M|White, James R|Mark Welch, Jessica L|Rossetti, Blair J|Peterson, Scott N|Snesrud, Erik C|Borisy, Gary G|Lazarev, Mark|Stein, Ellen|Vadivelu, Jamuna|Roslani, April C|Malik, Ausuma A|Wanyiri,
PMID: 25489084
Journal: BMC Cancer. 2014 Dec 24;14:997.
Title: Genome-wide identification of FoxO-dependent gene networks in skeletal muscle during C26 cancer cachexia.
Author: Judge, Sarah M|Wu, Chia-Ling|Beharry, Adam W|Roberts, Brandon M|Ferreira, Leonardo F|Kandarian, Susan C|Judge, Andrew R
PMID: 25539728
Journal: Free Radic Biol Med. 2014 Oct;75 Suppl 1:S27.
Title: The effect of resveratrol on signal transduction pathways and the role of pro-apoptotic Bax protein on apoptosis in HCT- 116 colon carcinoma cell lines.
Author: Crek, Ceyda|Mutlu Altundag, Ergul|Karademir, Betul|Kocturk, Semra|Kartal Ozer, Nesrin|Taga, Yavuz
PMID: 26461322
Journal: Bio Protoc. 2014 May 5;4(9).
Title: Immunostaining Protocol: P-Stat3 (Xenograft and Mice).
Author: Calon, Alexandre|Espinet, Elisa|Palomo-Ponce, Sergio|Tauriello, Daniele V F|Iglesias, Mar|Cespedes, Maria Virtudes|Sevillano, Marta|Nadal, Cristina|Jung, Peter|Zhang, Xiang H-F|Byrom, Daniel|Riera, Antoni|Rossell, David|Mangues, Ramon|Massague, Joan|Sanch
PMID: 29104885
Journal: Mol Carcinog. 2015 Oct;54(10):986-98.
Title: Adoptive transfer of regulatory T cells promotes intestinal tumorigenesis and is associated with decreased NK cells and IL-22 binding protein.
Author: Janakiram, Naveena B|Mohammed, Altaf|Bryant, Taylor|Brewer, Misty|Biddick, Laura|Lightfoot, Stan|Lang, Mark L|Rao, Chinthalapally V
PMID: 24797894
Journal: Oncogene. 2015 Jul;34(27):3493-503.
Title: Th17-type cytokines, IL-6 and TNF-alpha synergistically activate STAT3 and NF-kB to promote colorectal cancer cell growth.
Author: De Simone, V|Franze, E|Ronchetti, G|Colantoni, A|Fantini, M C|Di Fusco, D|Sica, G S|Sileri, P|MacDonald, T T|Pallone, F|Monteleone, G|Stolfi, C
PMID: 25174402
Journal: Oncol Rep. 2015 Jan;33(1):185-92.
Title: Effect of Smad3/4 on chemotherapeutic drug sensitivity in colorectal cancer cells.
Author: Moon, Sung Ung|Kang, Mi Hyun|Sung, Ji Hea|Kim, Jin Won|Lee, Jeong Ok|Kim, Yu Jung|Lee, Keun Wook|Bang, Soo Mee|Lee, Jong Seok|Kim, Jee Hyun
PMID: 25370208
Journal: Cell Signal. 2015 Feb;27(2):293-305.
Title: HSP90 inhibitor NVP-AUY922 enhances TRAIL-induced apoptosis by suppressing the JAK2-STAT3-Mcl-1 signal transduction pathway in colorectal cancer cells.
Author: Lee, Dae-Hee|Sung, Ki Sa|Bartlett, David L|Kwon, Yong Tae|Lee, Yong J
PMID: 25446253
Journal: Oncotarget. 2015 Feb 20;6(5):3043-54.
Title: Sunitinib prevents cachexia and prolongs survival of mice bearing renal cancer by restraining STAT3 and MuRF-1 activation in muscle.
Author: Pretto, Francesca|Ghilardi, Carmen|Moschetta, Michele|Bassi, Andrea|Rovida, Alessandra|Scarlato, Valentina|Talamini, Laura|Fiordaliso, Fabio|Bisighini, Cinzia|Damia, Giovanna|Bani, Maria Rosa|Piccirillo, Rosanna|Giavazzi, Raffaella
PMID: 25460504
Journal: Gastroenterology. 2015 Mar;148(3):579-89.
Title: Interleukin 6 alters localization of hMSH3, leading to DNA mismatch repair defects in colorectal cancer cells.
Author: Tseng-Rogenski, Stephanie S|Hamaya, Yasushi|Choi, Daniel Y|Carethers, John M
PMID: 25461668
Journal: DNA Cell Biol. 2015 Mar;34(3):178-88.
Title: The traditional Chinese medicinal formula BDL301 suppresses tumor growth by inhibiting STAT3 pathway and inducing apoptosis in colorectal cancer cells.
Author: Chu, Li|Zhao, Huaxin|Fang, Juemin|Li, Chunyan|Liu, Zhuqing|Cui, Ran|Hu, Fei|Zhang, Xi|Chen, Yijing|Han, Hui|Cao, Chuanhai|Xu, Qing
PMID: 25607688
Journal: Biochem Biophys Res Commun. 2015 Feb 20;457(4):681-7.
Title: Inhibition of STAT3/cyclinD1 pathway promotes chemotherapeutic sensitivity of colorectal caner.
Author: Qin, Ancheng|Yu, Qiang|Gao, Yuan|Tan, Jifu|Huang, Hai|Qiao, Zhiming|Qian, Weifeng
PMID: 25617735
Journal: Oncol Rep. 2015 Apr;33(4):1867-71.
Title: Cucurbitacin I inhibits cell migration and invasion and enhances chemosensitivity in colon cancer.
Author: Song, Junmin|Liu, Hongxiang|Li, Zhen|Yang, Chao|Wang, Chaojie
PMID: 25625299
Journal: Int J Oncol. 2015 Apr;46(4):1551-9.
Title: The effectiveness of an anti-human IL-6 receptor monoclonal antibody combined with chemotherapy to target colon cancer stem-like cells.
Author: Ying, Jin|Tsujii, Masahiko|Kondo, Jumpei|Hayashi, Yoshito|Kato, Motohiko|Akasaka, Tomofumi|Inoue, Takuta|Shiraishi, Eri|Inoue, Tahahiro|Hiyama, Satoshi|Tsujii, Yoshiki|Maekawa, Akira|Kawai, Shoichiro|Fujinaga, Tetsuji|Araki, Maekawa|Shinzaki, Shinichiro|W
PMID: 25625841
Journal: Am J Cancer Res. 2014 Dec 15;5(1):101-13. eCollection 2015.
Title: Myeloid cell leukemia-1 is associated with tumor progression by inhibiting apoptosis and enhancing angiogenesis in colorectal cancer.
Author: Lee, Wan-Sik|Park, Young-Lan|Kim, Nuri|Oh, Hyung-Hoon|Son, Dong-Jun|Kim, Mi-Young|Oak, Chan-Young|Chung, Cho-Yun|Park, Hyung-Chul|Kim, Jong-Sun|Myung, Dae-Seong|Cho, Sung-Bum|Kim, Hyun-Soo|Joo, Young-Eun
PMID: 25628923
Journal: Anticancer Res. 2015 Feb;35(2):645-51.
Title: Potential anticancer properties and mechanisms of action of curcumin.
Author: Vallianou, Natalia G|Evangelopoulos, Angelos|Schizas, Nikos|Kazazis, Christos
PMID: 25667441
Journal: J Med Chem. 2015 Mar 12;58(5):2452-64.
Title: Synthesis of CDDO-amino acid-nitric oxide donor trihybrids as potential antitumor agents against both drug-sensitive and drug-resistant colon cancer.
Author: Ai, Yong|Kang, Fenghua|Huang, Zhangjian|Xue, Xiaowen|Lai, Yisheng|Peng, Sixun|Tian, Jide|Zhang, Yihua
PMID: 25675144
Journal: World J Gastroenterol. 2015 Feb 14;21(6):1804-13.
Title: Overexpression of B7-H3 augments anti-apoptosis of colorectal cancer cells by Jak2-STAT3.
Author: Zhang, Ting|Jiang, Bo|Zou, Shi-Tao|Liu, Fen|Hua, Dong
PMID: 25684945
Journal: PLoS One. 2015 Feb 23;10(2):e0118391.
Title: Human papillomavirus infection correlates with inflammatory Stat3 signaling activity and IL-17 level in patients with colorectal cancer.
Author: Li, Yi Xin|Zhang, Lei|Simayi, Dilixia|Zhang, Nan|Tao, Lin|Yang, Lan|Zhao, Jin|Chen, Yun Zhao|Li, Feng|Zhang, Wen Jie
PMID: 25706309
Journal: FASEB J. 2015 Jun;29(6):2359-70.
Title: 15-Lipoxygenase-1 suppression of colitis-associated colon cancer through inhibition of the IL-6/STAT3 signaling pathway.
Author: Mao, Fei|Xu, Min|Zuo, Xiangsheng|Yu, Jiang|Xu, Weiguo|Moussalli, Micheline J|Elias, Elias|Li, Haiyan S|Watowich, Stephanie S|Shureiqi, Imad
PMID: 25713055
Journal: Cancer Res Treat. 2015 Oct;47(4):607-15.
Title: Phase I Study of OPB-31121, an Oral STAT3 Inhibitor, in Patients with Advanced Solid Tumors.
Author: Oh, Do-Youn|Lee, Se-Hoon|Han, Sae-Won|Kim, Mi-Jung|Kim, Tae-Min|Kim, Tae-You|Heo, Dae Seog|Yuasa, Miyuki|Yanagihara, Yasuo|Bang, Yung-Jue
PMID: 25715763
Journal: World J Gastroenterol. 2015 Feb 21;21(7):2047-57.
Title: Impact of high glucose on metastasis of colon cancer cells.
Author: Lin, Cheng-Yao|Lee, Chih-Hui|Huang, Chien-Cheng|Lee, Song-Tay|Guo, How-Ran|Su, Shih-Bin
PMID: 25717237
Journal: J Clin Invest. 2015 Mar 2;125(3):1362.
Title: Corrigendum. IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis.
Author: Rokavec, Matjaz|Oner, Meryem Gulfem|Li, Huihui|Jackstadt, Rene|Jiang, Longchang|Lodygin, Dmitri|Kaller, Markus|Horst, David|Ziegler, Paul K|Schwitalla, Sarah|Slotta-Huspenina, Julia|Bader, Franz G|Greten, Florian R|Hermeking, Heiko
PMID: 25729853
Journal: Nature. 2015 Mar 5;519(7541):57-62.
Title: A gp130-Src-YAP module links inflammation to epithelial regeneration.
Author: Taniguchi, Koji|Wu, Li-Wha|Grivennikov, Sergei I|de Jong, Petrus R|Lian, Ian|Yu, Fa-Xing|Wang, Kepeng|Ho, Samuel B|Boland, Brigid S|Chang, John T|Sandborn, William J|Hardiman, Gary|Raz, Eyal|Maehara, Yoshihiko|Yoshimura, Akihiko|Zucman-Rossi, Jessica|Guan
PMID: 25731159
Journal: J Exp Med. 2015 Mar 9;212(3):369-83.
Title: Epithelial NAIPs protect against colonic tumorigenesis.
Author: Allam, Ramanjaneyulu|Maillard, Michel H|Tardivel, Aubry|Chennupati, Vijaykumar|Bega, Hristina|Yu, Chi Wang|Velin, Dominique|Schneider, Pascal|Maslowski, Kendle M
PMID: 25732303
Journal: Carcinogenesis. 2015 Apr;36(4):459-68.
Title: Aberrantly expressed Fra-1 by IL-6/STAT3 transactivation promotes colorectal cancer aggressiveness through epithelial-mesenchymal transition.
Author: Liu, Hong|Ren, Guoping|Wang, Tingyang|Chen, Yuexia|Gong, Chaoju|Bai, Yanfeng|Wang, Bo|Qi, Hongyan|Shen, Jing|Zhu, Lijun|Qian, Cheng|Lai, Maode|Shao, Jimin
PMID: 25750173
Journal: Int J Clin Exp Pathol. 2015 Jan 1;8(1):615-21. eCollection 2015.
Title: Anticancer effect of salidroside on colon cancer through inhibiting JAK2/STAT3 signaling pathway.
Author: Sun, Kuan-Xue|Xia, Hong-Wei|Xia, Rong-Long
PMID: 25755753
Journal: Endocr Metab Immune Disord Drug Targets. 2015;15(2):88-96.
Title: Curcumin targets in inflammation and cancer.
Author: Deguchi, Atsuko
PMID: 25772169
Journal: Ann Surg Oncol. 2015 Dec;22 Suppl 3:S1548-55.
Title: Expressional STAT3/STAT5 Ratio is an Independent Prognostic Marker in Colon Carcinoma.
Author: Klupp, Fee|Diers, Johannes|Kahlert, Christoph|Neumann, Lena|Halama, Niels|Franz, Clemens|Schmidt, Thomas|Lasitschka, Felix|Warth, Arne|Weitz, Juergen|Koch, Moritz|Schneider, Martin|Ulrich, Alexis
PMID: 25773877
Journal: Cell Signal. 2015 Jul;27(7):1525-32.
Title: Pyruvate kinase M2 accelerates pro-inflammatory cytokine secretion and cell proliferation induced by lipopolysaccharide in colorectal cancer.
Author: Yang, Peng|Li, Zongwei|Li, Hanqing|Lu, Yangxu|Wu, Haili|Li, Zhuoyu
PMID: 25778902
Journal: J Biol Chem. 2015 Apr 24;290(17):11177-87.
Title: Inhibition of Stat3 activation suppresses caspase-3 and the ubiquitin-proteasome system, leading to preservation of muscle mass in cancer cachexia.
Author: Silva, Kleiton Augusto Santos|Dong, Jiangling|Dong, Yanjun|Dong, Yanlan|Schor, Nestor|Tweardy, David J|Zhang, Liping|Mitch, William E
PMID: 25787076
Journal: Oncol Lett. 2015 Apr;9(4):1962-1970.
Title: Hedyotis diffusa Willd. extract suppresses proliferation and induces apoptosis via IL-6-inducible STAT3 pathway inactivation in human colorectal cancer cells.
Author: Lin, Jiumao|Li, Qiongyu|Chen, Hongwei|Lin, Hui|Lai, Zijun|Peng, Jun
PMID: 25789077
Journal: Oncotarget. 2015 Apr 10;6(10):7713-26.
Title: Adipose-derived stem cells promote tumor initiation and accelerate tumor growth by interleukin-6 production.
Author: Wei, Hong-Jian|Zeng, Rong|Lu, Jui-Hua|Lai, Wen-Fu T|Chen, Wei-Hong|Liu, Hen-Yu|Chang, Ya-Ting|Deng, Win-Ping
PMID: 25797257
Journal: Clin Cancer Res. 2015 Jul 15;21(14):3230-3240.
Title: HDAC Inhibition Overcomes Acute Resistance to MEK Inhibition in BRAF-Mutant Colorectal Cancer by Downregulation of c-FLIPL.
Author: Carson, Robbie|Celtikci, Basak|Fenning, Cathy|Javadi, Arman|Crawford, Nyree|Carbonell, Lucia Perez|Lawler, Mark|Longley, Daniel B|Johnston, Patrick G|Van Schaeybroeck, Sandra
PMID: 25813020
Journal: Cell Physiol Biochem. 2015;35(5):1821-30.
Title: Cinnamaldehyde derivative (CB-PIC) sensitizes chemo-resistant cancer cells to drug-induced apoptosis via suppression of MDR1 and its upstream STAT3 and AKT signalling.
Author: Yun, Miyong|Lee, Duckgue|Park, Moon-Nyeo|Kim, Eun-Ok|Sohn, Eun Jung|Kwon, Byung-Mog|Kim, Sung-Hoon
PMID: 25833196
Journal: Oncotarget. 2015 Apr 30;6(12):9908-23.
Title: Interleukin-21 sustains inflammatory signals that contribute to sporadic colon tumorigenesis.
Author: De Simone, Veronica|Ronchetti, Giulia|Franze, Eleonora|Colantoni, Alfredo|Ortenzi, Angela|Fantini, Massimo C|Rizzo, Angelamaria|Sica, Giuseppe S|Sileri, Pierpaolo|Rossi, Piero|MacDonald, Thomas T|Pallone, Francesco|Monteleone, Giovanni|Stolfi, Carmine
PMID: 25839161
Journal: World J Surg Oncol. 2015 Apr 12;13:146.
Title: Dysregulation of over-expressed IL-32 in colorectal cancer induces metastasis.
Author: Yang, Yi|Wang, Zihao|Zhou, Yiming|Wang, Xiaoxiao|Xiang, Jianbin|Chen, Zongyou
PMID: 25889282
Journal: J Transl Med. 2015 Feb 12;13:57.
Title: Tumour pharmacodynamics and circulating cell free DNA in patients with refractory colorectal carcinoma treated with regorafenib.
Author: Wong, Andrea Li Ann|Lim, Joline Si Jing|Sinha, Arvind|Gopinathan, Anil|Lim, Robert|Tan, Chee-Seng|Soh, Thomas|Venkatesh, Sudhakar|Titin, Christina|Sapari, Nur Sabrina|Lee, Soo-Chin|Yong, Wei-Peng|Tan, David Shao Ping|Pang, Brendan|Wang, Ting-Ting|Zee, Yin
PMID: 25889309
Journal: Oncotarget. 2015 Apr 20;6(11):8539-51.
Title: Pharmacological inhibition of p38 MAPK reduces tumor growth in patient-derived xenografts from colon tumors.
Author: Gupta, Jalaj|Igea, Ana|Papaioannou, Marilena|Lopez-Casas, Pedro Pablo|Llonch, Elisabet|Hidalgo, Manuel|Gorgoulis, Vassilis G|Nebreda, Angel R
PMID: 25890501
Journal: World J Gastroenterol. 2015 Apr 14;21(14):4216-24.
Title: Th22 cell accumulation is associated with colorectal cancer development.
Author: Huang, Yong-Hong|Cao, Yun-Fei|Jiang, Zhi-Yuan|Zhang, Sen|Gao, Feng
PMID: 25892871
Journal: Mol Med Rep. 2015 Aug;12(2):2107-13.
Title: Ubiquitin-specific peptidase 22 inhibits colon cancer cell invasion by suppressing the signal transducer and activator of transcription 3/matrix metalloproteinase 9 pathway.
Author: Ao, Ning|Liu, Yanyan|Bian, Xiaocui|Feng, Hailiang|Liu, Yuqin
PMID: 25902005
Journal: Mol Cell Biochem. 2015 Aug;406(1-2):63-73.
Title: Cryptotanshinone, a Stat3 inhibitor, suppresses colorectal cancer proliferation and growth in vitro.
Author: Li, Weidong|Saud, Shakir M|Young, Matthew R|Colburn, Nancy H|Hua, Baojin
PMID: 25912550
Journal: J Transl Med. 2015 May 7;13:144.
Title: Glutamate dehydrogenase is a novel prognostic marker and predicts metastases in colorectal cancer patients.
Author: Liu, Gaojie|Zhu, Jie|Yu, Menglei|Cai, Canfeng|Zhou, Yu|Yu, Min|Fu, Zhiqiang|Gong, Yuanfeng|Yang, Bin|Li, Yingru|Zhou, Quanbo|Lin, Qin|Ye, Huilin|Ye, Liangtao|Zhao, Xiaohui|Li, Zhihua|Chen, Rufu|Han, Fanghai|Tang, Chaoming|Zeng, Bing
PMID: 25947346
Journal: PLoS One. 2015 May 8;10(5):e0123478.
Title: Berberine Inhibits Invasion and Metastasis of Colorectal Cancer Cells via COX-2/PGE2 Mediated JAK2/STAT3 Signaling Pathway.
Author: Liu, Xuan|Ji, Qing|Ye, Naijing|Sui, Hua|Zhou, Lihong|Zhu, Huirong|Fan, Zhongze|Cai, Jianfeng|Li, Qi
PMID: 25954974
Journal: Oncotarget. 2015 Jun 10;6(16):14472-87.
Title: Rational combination of MEK inhibitor and the STAT3 pathway modulator for the therapy in K-Ras mutated pancreatic and colon cancer cells.
Author: Zhao, Chengguang|Xiao, Hui|Wu, Xiaojuan|Li, Chenglong|Liang, Guang|Yang, Shulin|Lin, Jiayuh
PMID: 25961376
Journal: Cell Cycle. 2015;14(16):2667-76.
Title: Leptin activation of mTOR pathway in intestinal epithelial cell triggers lipid droplet formation, cytokine production and increased cell proliferation.
Author: Fazolini, Narayana P B|Cruz, Andre L S|Werneck, Miriam B F|Viola, Joao P B|Maya-Monteiro, Clarissa M|Bozza, Patricia T
PMID: 26017929
Journal: PLoS One. 2015 May 29;10(5):e0127356.
Title: Prognostic Role of Phospho-STAT3 in Patients with Cancers of the Digestive System: A Systematic Review and Meta-Analysis.
Author: Li, Mu-xing|Bi, Xin-yu|Huang, Zhen|Zhao, Jian-jun|Han, Yue|Li, Zhi-Yu|Zhang, Ye-fan|Li, Yuan|Chen, Xiao|Hu, Xu-hui|Zhao, Hong|Cai, Jian-qiang
PMID: 26024373
Journal: Int J Clin Exp Pathol. 2015 Mar 1;8(3):2919-27. eCollection 2015.
Title: ING4 enhances paclitaxel's effect on colorectal cancer growth in vitro and in vivo.
Author: Cao, Liyu|Chen, Shunhua|Zhang, Cong|Chen, Cong|Lu, Nana|Jiang, Yan|Cai, Yongping|Yin, Yu|Xu, Jianming
PMID: 26045800
Journal: Gastroenterology. 2015 Oct;149(4):981-92.e11.
Title: MicroRNA214 Is Associated With Progression of Ulcerative Colitis, and Inhibition Reduces Development of Colitis and Colitis-Associated Cancer in Mice.
Author: Polytarchou, Christos|Hommes, Daniel W|Palumbo, Tiziana|Hatziapostolou, Maria|Koutsioumpa, Marina|Koukos, Georgios|van der Meulen-de Jong, Andrea E|Oikonomopoulos, Angelos|van Deen, Welmoed K|Vorvis, Christina|Serebrennikova, Oksana B|Birli, Eleni|Choi, J
PMID: 26055138
Journal: Biomed Res Int. 2015;2015:326981.
Title: Role of B7-H4 siRNA in Proliferation, Migration, and Invasion of LOVO Colorectal Carcinoma Cell Line.
Author: Peng, Hai-Xia|Wu, Wei-Qi|Yang, Da-Ming|Jing, Rong|Li, Ji|Zhou, Feng-Li|Jin, Yun-Fei|Wang, Sai-Yu|Chu, Yi-Min
PMID: 26078947
Journal: Oncotarget. 2015 Jun 10;6(16):14026-32.
Title: Soluble IL6R represents a miR-34a target: potential implications for the recently identified IL-6R/STAT3/miR-34a feed-back loop.
Author: Li, Huihui|Rokavec, Matjaz|Hermeking, Heiko
PMID: 26091352
Journal: J Biol Chem. 2015 Aug 7;290(32):19976-86.
Title: A Key Role for Leukemia Inhibitory Factor in C26 Cancer Cachexia.
Author: Seto, Danielle N|Kandarian, Susan C|Jackman, Robert W
PMID: 26092726
Journal: Inflamm Bowel Dis. 2015 Sep;21(9):2078-89.
Title: GPx2 Induction Is Mediated Through STAT Transcription Factors During Acute Colitis.
Author: Hiller, Franziska|Besselt, Karolin|Deubel, Stefanie|Brigelius-Flohe, Regina|Kipp, Anna P
PMID: 26115075
Journal: Tumour Biol. 2015 Dec;36(12):9475-86.
Title: BMP-2 induces motility and invasiveness by promoting colon cancer stemness through STAT3 activation.
Author: Kim, Bo Ram|Oh, Sang Cheul|Lee, Dae-Hee|Kim, Jung Lim|Lee, Suk Young|Kang, Myoung Hee|Lee, Sun Il|Kang, Sanghee|Joung, Sung Yup|Min, Byung Wook
PMID: 26124007
Journal: Genet Mol Res. 2015 May 29;14(2):5793-803.
Title: Effect of Rhizoma paridis total saponins on apoptosis of colorectal cancer cells and imbalance of the JAK/STAT3 molecular pathway induced by IL-6 suppression.
Author: Teng, W-J|Chen, P|Zhu, F-Y|Di, K|Zhou, C|Zhuang, J|Cao, X-J|Yang, J|Deng, L-J|Sun, C-G
PMID: 26125778
Journal: Cancer Immunol Res. 2015 Nov;3(11):1227-35.
Title: IL10R2 Overexpression Promotes IL22/STAT3 Signaling in Colorectal Carcinogenesis.
Author: Khare, Vineeta|Paul, Gregor|Movadat, Oliver|Frick, Adrian|Jambrich, Manuela|Krnjic, Anita|Marian, Brigitte|Wrba, Friedrich|Gasche, Christoph
PMID: 26130064
Journal: Oncoimmunology. 2015 Jan 22;4(4):e998529.
Title: Myeloid STAT3 promotes formation of colitis-associated colorectal cancer in mice.
Author: Pathria, Paulina|Gotthardt, Dagmar|Prchal-Murphy, Michaela|Putz, Eva-Maria|Holcmann, Martin|Schlederer, Michaela|Grabner, Beatrice|Crncec, Ilija|Svinka, Jasmin|Musteanu, Monica|Hoffmann, Thomas|Filipits, Martin|Berger, Walter|Poli, Valeria|Kenner, Lukas|B
PMID: 26137415
Journal: Cell Rep. 2015 Jul 14;12(2):244-57.
Title: CCL2 Promotes Colorectal Carcinogenesis by Enhancing Polymorphonuclear Myeloid-Derived Suppressor Cell Population and Function.
Author: Chun, Eunyoung|Lavoie, Sydney|Michaud, Monia|Gallini, Carey Ann|Kim, Jason|Soucy, Genevieve|Odze, Robert|Glickman, Jonathan N|Garrett, Wendy S
PMID: 26146082
Journal: Mol Med Rep. 2015 Oct;12(4):5455-60.
Title: B7H3 promotes cell migration and invasion through the Jak2/Stat3/MMP9 signaling pathway in colorectal cancer.
Author: Liu, Fen|Zhang, Ting|Zou, Shitao|Jiang, Bo|Hua, Dong
PMID: 26151358
Journal: J Nat Sci. 2015;1(7):e131.
Title: LIF is a new p53 negative regulator.
Author: Liu, Juan|Yu, Haiyang|Hu, Wenwei
PMID: 26161442
Journal: Anticancer Res. 2015 Aug;35(8):4473-7.
Title: Molecular Response of Human Monocytes Following Interaction with Colon Cancer Cells by Pre-treatment with Low-dose Lipopolysaccharide.
Author: Honda, Teruko|Inagawa, Hiroyuki
PMID: 26168489
Journal: Br J Cancer. 2015 Aug 11;113(4):669-79.
Title: Effects of growth arrest and DNA damage-inducible protein 34 (GADD34) on inflammation-induced colon cancer in mice.
Author: Tanaka, Yuriko|Ito, Sachiko|Oshino, Reina|Chen, Nana|Nishio, Naomi|Isobe, Ken-ichi
PMID: 26196182
Journal: Growth Horm IGF Res. 2015 Oct;25(5):253-61.
Title: Crosstalk between the TNF and IGF pathways enhances NF-kappaB activation and signaling in cancer cells.
Author: Li, Shun|Pinard, Maxime|Wang, Yunling|Yang, Long|Lin, Rongtuan|Hiscott, John|Su, Bing|Brodt, Pnina
PMID: 26239406
Journal: J Biol Chem. 2015 Sep 25;290(39):23838-49.
Title: The Mutant KRAS Gene Up-regulates BCL-XL Protein via STAT3 to Confer Apoptosis Resistance That Is Reversed by BIM Protein Induction and BCL-XL Antagonism.
Author: Zaanan, Aziz|Okamoto, Koichi|Kawakami, Hisato|Khazaie, Khashayarsha|Huang, Shengbing|Sinicrope, Frank A
PMID: 26245900
Journal: PLoS One. 2015 Aug 10;10(8):e0134948.
Title: Identification of Novel Biomarkers for Metastatic Colorectal Cancer Using Angiogenesis-Antibody Array and Intracellular Signaling Array.
Author: Chung, Seyung|Dwabe, Sami|Elshimali, Yayha|Sukhija, Hemlata|Aroh, Clement|Vadgama, Jaydutt V
PMID: 26258407
Journal: Bioorg Med Chem Lett. 2015 Oct 1;25(19):4287-92.
Title: Probing a 3,4'-bis-guanidinium diaryl derivative as an allosteric inhibitor of the Ras pathway.
Author: Diez-Cecilia, Elena|Carson, Robert|Kelly, Brendan|van Schaeybroeck, Sandra|Murray, James T|Rozas, Isabel
PMID: 26318998
Journal: Int Immunopharmacol. 2015 Oct;28(2):1034-43.
Title: Gallic acid suppresses inflammation in dextran sodium sulfate-induced colitis in mice: Possible mechanisms.
Author: Pandurangan, Ashok Kumar|Mohebali, Nooshin|Esa, Norhaizan Mohd|Looi, Chung Yeng|Ismail, Salmiah|Saadatdoust, Zeinab
PMID: 26319951
Journal: Gastroenterology. 2015 Dec;149(7):1860-1871.e8.
Title: Human Colon Tumors Express a Dominant-Negative Form of SIGIRR That Promotes Inflammation and Colitis-Associated Colon Cancer in Mice.
Author: Zhao, Junjie|Bulek, Katarzyna|Gulen, Muhammet F|Zepp, Jarod A|Karagkounis, Georgio|Martin, Bradley N|Zhou, Hao|Yu, Minjia|Liu, Xiuli|Huang, Emina|Fox, Paul L|Kalady, Matthew F|Markowitz, Sanford D|Li, Xiaoxia
PMID: 26344057
Journal: J Nutr Biochem. 2015 Dec;26(12):1547-58.
Title: Dietary cocoa inhibits colitis associated cancer: a crucial involvement of the IL-6/STAT3 pathway.
Author: Saadatdoust, Zeinab|Pandurangan, Ashok Kumar|Ananda Sadagopan, Suresh Kumar|Mohd Esa, Norhaizan|Ismail, Amin|Mustafa, Mohd Rais
PMID: 26355019
Journal: Oncotarget. 2015 Oct 13;6(31):32013-26.
Title: Berberine may rescue Fusobacterium nucleatum-induced colorectal tumorigenesis by modulating the tumor microenvironment.
Author: Yu, Ya-Nan|Yu, Ta-Chung|Zhao, Hui-Jun|Sun, Tian-Tian|Chen, Hui-Min|Chen, Hao-Yan|An, Hui-Fang|Weng, Yu-Rong|Yu, Jun|Li, Min|Qin, Wen-Xin|Ma, Xiong|Shen, Nan|Hong, Jie|Fang, Jing-Yuan
PMID: 26397137
Journal: Future Oncol. 2015;11(21):2911-22.
Title: Cellular signaling pathways implicated in metastasis of colorectal cancer and the associated targeted agents.
Author: Liu, Xuan|Ji, Qing|Fan, Zhongze|Li, Qi
PMID: 26414153
Journal: PLoS One. 2015 Sep 29;10(9):e0139094.
Title: LPA Induces Colon Cancer Cell Proliferation through a Cooperation between the ROCK and STAT-3 Pathways.
Author: Leve, Fernanda|Peres-Moreira, Rubem J|Binato, Renata|Abdelhay, Eliana|Morgado-Diaz, Jose A
PMID: 26418031
Journal: Sci Signal. 2015 Oct 6;8(397):ra98.
Title: Tumor-selective proteotoxicity of verteporfin inhibits colon cancer progression independently of YAP1.
Author: Zhang, Huabing|Ramakrishnan, Sadeesh K|Triner, Daniel|Centofanti, Brook|Maitra, Dhiman|Gyorffy, Balazs|Sebolt-Leopold, Judith S|Dame, Michael K|Varani, James|Brenner, Dean E|Fearon, Eric R|Omary, M Bishr|Shah, Yatrik M
PMID: 26443705
Journal: Oncotarget. 2015 Nov 10;6(35):38195-209.
Title: Mechanisms linking obesity to altered metabolism in mice colon carcinogenesis.
Author: Nimri, Lili|Saadi, Janan|Peri, Irena|Yehuda-Shnaidman, Einav|Schwartz, Betty
PMID: 26472027
Journal: J Cancer Prev. 2015 Sep;20(3):185-92.
Title: Withaferin-A Inhibits Colon Cancer Cell Growth by Blocking STAT3 Transcriptional Activity.
Author: Choi, Bu Young|Kim, Bong-Woo
PMID: 26473157
Journal: Oncotarget. 2015 Dec 8;6(39):41929-43.
Title: (E)-4-(3-(3,5-dimethoxyphenyl)allyl)-2-methoxyphenol inhibits growth of colon tumors in mice.
Author: Zheng, Jie|Park, Mi Hee|Son, Dong Ju|Choi, Min Gi|Choi, Jeong Soon|Nam, Kyung Tak|Kim, Hae Deun|Rodriguez, Kevin|Gann, Benjamin|Ham, Young Wan|Han, Sang Bae|Hong, Jin Tae
PMID: 26474284
Journal: Neoplasia. 2015 Sep;17(9):687-696.
Title: Pharmacological Targeting SHP-1-STAT3 Signaling Is a Promising Therapeutic Approach for the Treatment of Colorectal Cancer.
Author: Fan, Li-Ching|Teng, Hao-Wei|Shiau, Chung-Wai|Tai, Wei-Tien|Hung, Man-Hsin|Yang, Shung-Haur|Jiang, Jeng-Kai|Chen, Kuen-Feng
PMID: 26476076
Journal: Cell Mol Gastroenterol Hepatol. 2015 Nov 1;1(6):610-630.
Title: Diminished expression of CRHR2 in human colon cancer promotes tumor growth and EMT via persistent IL-6/Stat3 signaling.
Author: Rodriguez, Jorge A|Huerta-Yepez, Sara|Law, Ivy Ka Man|Baay-Guzman, Guillermina J|Tirado-Rodriguez, Belen|Hoffman, Jill M|Iliopoulos, Dimitrios|Hommes, Daniel W|Verspaget, Hein W|Chang, Lin|Pothoulakis, Charalabos|Baritaki, Stavroula
PMID: 26495412
Journal: Oncotarget. 2015 Nov 10;6(35):38166-80.
Title: Molecular profiling of cetuximab and bevacizumab treatment of colorectal tumours reveals perturbations in metabolic and hypoxic response pathways.
Author: Greening, David W|Lee, Sze Ting|Ji, Hong|Simpson, Richard J|Rigopoulos, Angela|Murone, Carmel|Fang, Catherine|Gong, Sylvia|O'Keefe, Graeme|Scott, Andrew M
PMID: 26517691
Journal: Sci Rep. 2015 Nov 6;5:16082.
Title: Nuclear PKM2 contributes to gefitinib resistance via upregulation of STAT3 activation in colorectal cancer.
Author: Li, Qiong|Zhang, Daoxiang|Chen, Xiaoying|He, Lei|Li, Tianming|Xu, Xiaoping|Li, Min
PMID: 26542452
Journal: Int J Clin Exp Med. 2015 Aug 15;8(8):12009-17. eCollection 2015.
Title: IL-6/STAT3/SOCS3 signaling pathway playing a regulatory role in ulcerative colitis carcinogenesis.
Author: Chen, Ying-Ying|Ma, Zhi-Bin|Xu, Hong-Yu|Shi, Li-Jun|Li, Dong-Yue|Sun, Li-Ying|Yin, Xun-Hai|Sang, Guo-Yin|Xu, Dan|Tang, Yin-Hua|Wang, Xi|Li, Peng|Wu, Feng|Zhou, Jin
PMID: 26550113
Journal: Int J Mol Sci. 2015 Nov 16;16(11):27411-21.
Title: Evodiamine Induces Apoptosis and Inhibits Migration of HCT-116 Human Colorectal Cancer Cells.
Author: Zhao, Lv-Cui|Li, Jing|Liao, Ke|Luo, Nian|Shi, Qing-Qiang|Feng, Zi-Qiang|Chen, Di-Long
PMID: 26580615
Journal: Mar Drugs. 2015 Nov 19;13(11):6962-76.
Title: Salternamide A Suppresses Hypoxia-Induced Accumulation of HIF-1alpha and Induces Apoptosis in Human Colorectal Cancer Cells.
Author: Bach, Duc-Hiep|Kim, Seong-Hwan|Hong, Ji-Young|Park, Hyen Joo|Oh, Dong-Chan|Lee, Sang Kook
PMID: 26610526
Journal: J Exp Med. 2015 Dec 14;212(13):2235-51.
Title: IKKbeta in intestinal mesenchymal cells promotes initiation of colitis-associated cancer.
Author: Koliaraki, Vasiliki|Pasparakis, Manolis|Kollias, George
PMID: 26621453
Journal: Exp Ther Med. 2015 Oct;10(4):1602-1608.
Title: Scutellaria barbata D. Don inhibits growth and induces apoptosis by suppressing IL-6-inducible STAT3 pathway activation in human colorectal cancer cells.
Author: Jiang, Qiqin|Li, Qiongyu|Chen, Hongwei|Shen, Aling|Cai, Qiaoyan|Lin, Jiumao|Peng, Jun
PMID: 26622533
Journal: PLoS One. 2015 Dec 9;10(12):e0144322.
Title: Hes1 Increases the Invasion Ability of Colorectal Cancer Cells via the STAT3-MMP14 Pathway.
Author: Weng, M T|Tsao, P N|Lin, H L|Tung, C C|Change, M C|Chang, Y T|Wong, J M|Wei, S C
PMID: 26650241
Journal: BMC Cancer. 2015 Dec 16;15:975.
Title: Interleukin-6 trans-signaling increases the expression of carcinoembryonic antigen-related cell adhesion molecules 5 and 6 in colorectal cancer cells.
Author: Holmer, Reinhild|Watzig, Georg H|Tiwari, Sanjay|Rose-John, Stefan|Kalthoff, Holger
PMID: 26673628
Journal: Int J Exp Pathol. 2015 Dec;96(6):362-9.
Title: Multiple pathways regulate Cten in colorectal cancer without a Tensin switch.
Author: Thorpe, Hannah|Akhlaq, Maham|Jackson, Darryl|Al Ghamdi, Saleh|Storr, Sarah|Martin, Stewart|Ilyas, Mohammad
PMID: 26852686
Journal: Transl Cancer Res. 2015 Oct 1;4(5):469-483.
Title: Sphingosine-1-phosphate in inflammatory bowel disease and colitis-associated colon cancer: the fat's in the fire.
Author: Suh, Jung H|Saba, Julie D
PMID: 27011900
Journal: Cell Discov. 2015 May 19;1:15005.
Title: Modulation of tumorigenesis by the pro-inflammatory microRNA miR-301a in mouse models of lung cancer and colorectal cancer.
Author: Ma, Xiaodong|Yan, Fang|Deng, Qipan|Li, Fenge|Lu, Zhongxin|Liu, Mofang|Wang, Lisheng|Conklin, Daniel J|McCracken, James|Srivastava, Sanjay|Bhatnagar, Aruni|Li, Yong
PMID: 27462406
Journal: Sci Rep. 2015 Sep 1;5:13650.
Title: IL-11 induces differentiation of myeloid-derived suppressor cells through activation of STAT3 signalling pathway.
Author: Sumida, Kentaro|Ohno, Yosuke|Ohtake, Junya|Kaneumi, Shun|Kishikawa, Takuto|Takahashi, Norihiko|Taketomi, Akinobu|Kitamura, Hidemitsu
PMID: 28781374
Journal: Mol Carcinog. 2016 Mar;55(3):233-44.
Title: PAC exhibits potent anti-colon cancer properties through targeting cyclin D1 and suppressing epithelial-to-mesenchymal transition.
Author: Al-Qasem, Abeer|Al-Howail, Huda A|Al-Swailem, Mashael|Al-Mazrou, Amer|Al-Otaibi, Basem|Al-Jammaz, Ibrahim|Al-Khalaf, Huda H|Aboussekhra, Abdelilah
PMID: 25641341
Journal: Gut. 2016 May;65(5):821-9.
Title: Carcinoembryonic Antigen Cell Adhesion Molecule 1 long isoform modulates malignancy of poorly differentiated colon cancer cells.
Author: Arabzadeh, Azadeh|Dupaul-Chicoine, Jeremy|Breton, Valerie|Haftchenary, Sina|Yumeen, Sara|Turbide, Claire|Saleh, Maya|McGregor, Kevin|Greenwood, Celia M T|Akavia, Uri David|Blumberg, Richard S|Gunning, Patrick T|Beauchemin, Nicole
PMID: 25666195
Journal: Mol Carcinog. 2016 May;55(5):600-10.
Title: Antagonizing pathways leading to differential dynamics in colon carcinogenesis in Shugoshin1 (Sgo1)-haploinsufficient chromosome instability model.
Author: Rao, Chinthalapally V|Sanghera, Saira|Zhang, Yuting|Biddick, Laura|Reddy, Arun|Lightfoot, Stan|Dai, Wei|Yamada, Hiroshi Y
PMID: 25773652
Journal: Oncogene. 2016 Feb 25;35(8):939-51.
Title: Targeting JAK kinase in solid tumors: emerging opportunities and challenges.
Author: Buchert, M|Burns, C J|Ernst, M
PMID: 25982279
Journal: Gut. 2016 Sep;65(9):1470-81.
Title: Novel evidence for an oncogenic role of microRNA-21 in colitis-associated colorectal cancer.
Author: Shi, Chenzhang|Yang, Yongzhi|Xia, Yang|Okugawa, Yoshinaga|Yang, Jun|Liang, Yong|Chen, Hongqi|Zhang, Peng|Wang, Feng|Han, Huazhong|Wu, Wen|Gao, Renyuan|Gasche, Christoph|Qin, Huanlong|Ma, Yanlei|Goel, Ajay
PMID: 25994220
Journal: Mol Carcinog. 2016 Jun;55(6):1096-110.
Title: Carnosic acid inhibits STAT3 signaling and induces apoptosis through generation of ROS in human colon cancer HCT116 cells.
Author: Kim, Do-Hee|Park, Ki-Woong|Chae, In Gyeong|Kundu, Juthika|Kim, Eun-Hee|Kundu, Joydeb Kumar|Chun, Kyung-Soo
PMID: 26152521
Journal: Hum Exp Toxicol. 2016 May;35(5):526-43.
Title: Treatment with cucurbitacin B alone and in combination with gefitinib induces cell cycle inhibition and apoptosis via EGFR and JAK/STAT pathway in human colorectal cancer cell lines.
Author: Yar Saglam, A S|Alp, E|Elmazoglu, Z|Menevse, S
PMID: 26183715
Journal: Eur J Cancer Prev. 2016 Nov;25(6):481-9.
Title: Anti-Warburg effect of rosmarinic acid via miR-155 in colorectal carcinoma cells.
Author: Xu, Yichun|Han, Shuai|Lei, Kesheng|Chang, Xinnan|Wang, Ke|Li, Zhou|Liu, Jianwen
PMID: 26340059
Journal: Oncogene. 2016 May 19;35(20):2634-44.
Title: Targeting colorectal cancer via its microenvironment by inhibiting IGF-1 receptor-insulin receptor substrate and STAT3 signaling.
Author: Sanchez-Lopez, E|Flashner-Abramson, E|Shalapour, S|Zhong, Z|Taniguchi, K|Levitzki, A|Karin, M
PMID: 26364612
Journal: Tumour Biol. 2016 May;37(5):6561-9.
Title: Genetic variants in IL-6/JAK/STAT3 pathway and the risk of CRC.
Author: Wang, Shuwei|Zhang, Weidong
PMID: 26638167
Journal: Mol Carcinog. 2016 Dec;55(12):2010-2023.
Title: Interleukin-6 increases expression of serine protease inhibitor Kazal type 1 through STAT3 in colorectal adenocarcinoma.
Author: Rasanen, Kati|Lehtinen, Elina|Nokelainen, Kristiina|Kuopio, Teijo|Hautala, Laura|Itkonen, Outi|Stenman, Ulf-Hakan|Koistinen, Hannu
PMID: 26663388
Journal: Oncotarget. 2016 Feb 16;7(7):7667-82.
Title: Sonic hedgehog inhibitors prevent colitis-associated cancer via orchestrated mechanisms of IL-6/gp130 inhibition, 15-PGDH induction, Bcl-2 abrogation, and tumorsphere inhibition.
Author: Kangwan, Napapan|Kim, Yoon-Jae|Han, Young Min|Jeong, Migyeong|Park, Jong-Min|Go, Eun-Jin|Hahm, Ki-Baik
PMID: 26716648
Journal: Cancer Immunol Immunother. 2016 Feb;65(2):193-204.
Title: IL-6 down-regulates HLA class II expression and IL-12 production of human dendritic cells to impair activation of antigen-specific CD4(+) T cells.
Author: Ohno, Yosuke|Kitamura, Hidemitsu|Takahashi, Norihiko|Ohtake, Junya|Kaneumi, Shun|Sumida, Kentaro|Homma, Shigenori|Kawamura, Hideki|Minagawa, Nozomi|Shibasaki, Susumu|Taketomi, Akinobu
PMID: 26759006
Journal: Cytokine. 2016 Mar;79:82-9.
Title: Colorectal cancer cell-derived interleukin-6 enhances the phagocytic capacity and migration of THP-1 cells.
Author: Yeh, Kun-Yun|Wu, Tsung-Han|Wu, Tai-Ling
PMID: 26775116
Journal: Mol Med Rep. 2016 Mar;13(3):2235-40.
Title: Eriocalyxin B blocks human SW1116 colon cancer cell proliferation, migration, invasion, cell cycle progression and angiogenesis via the JAK2/STAT3 signaling pathway.
Author: Lu, Yun-Min|Chen, Wei|Zhu, Jin-Shui|Chen, Wei-Xiong|Chen, Ni-Wei
PMID: 26795301
Journal: Protein Cell. 2016 Feb;7(2):130-40.
Title: G-CSF is a key modulator of MDSC and could be a potential therapeutic target in colitis-associated colorectal cancers.
Author: Li, Wenbin|Zhang, Xinghua|Chen, Yongkang|Xie, Yibin|Liu, Jiancheng|Feng, Qiang|Wang, Yi|Yuan, Wei|Ma, Jie
PMID: 26797765
Journal: Oncotarget. 2016 Feb 9;7(6):7307-17.
Title: IL-32theta inhibits stemness and epithelial-mesenchymal transition of cancer stem cells via the STAT3 pathway in colon cancer.
Author: Bak, Yesol|Kwon, Taeho|Bak, In Seon|Hong, Jintae|Yu, Dae-Yeul|Yoon, Do-Young
PMID: 26824417
Journal: Stem Cells. 2016 Apr;34(4):820-31.
Title: IGF/STAT3/NANOG/Slug Signaling Axis Simultaneously Controls Epithelial-Mesenchymal Transition and Stemness Maintenance in Colorectal Cancer.
Author: Yao, Chao|Su, Li|Shan, Juanjuan|Zhu, Chuanlin|Liu, Limei|Liu, Chungang|Xu, Yanmin|Yang, Zhi|Bian, Xiuwu|Shao, Jimin|Li, Jianming|Lai, Maode|Shen, Junjie|Qian, Cheng
PMID: 26840943
Journal: FEBS J. 2016 Apr;283(8):1438-52.
Title: Targeted deletion of miR-139-5p activates MAPK, NF-kappaB and STAT3 signaling and promotes intestinal inflammation and colorectal cancer.
Author: Zou, Fangyuan|Mao, Rurong|Yang, Liyan|Lin, Shengchao|Lei, Kecheng|Zheng, Yuanhong|Ding, Yue|Zhang, Peng|Cai, Guoxiang|Liang, Xin|Liu, Jianwen
PMID: 26859226
Journal: Am J Physiol Gastrointest Liver Physiol. 2016 Apr 15;310(8):G586-98.
Title: Deletion of Na+/H+ exchanger regulatory factor 2 represses colon cancer progress by suppression of Stat3 and CD24.
Author: Yoshida, Michihiro|Zhao, Luqing|Grigoryan, Gevorg|Shim, Hyunsuk|He, Peijian|Yun, C Chris
PMID: 26867566
Journal: Oncotarget. 2016 Mar 8;7(10):11567-79.
Title: HIF-3alpha1 promotes colorectal tumor cell growth by activation of JAK-STAT3 signaling.
Author: Xue, Xiang|Jungles, Kylie|Onder, Gunseli|Samhoun, Jalal|Gyorffy, Balazs|Hardiman, Karin M
PMID: 26871465
Journal: Eur Rev Med Pharmacol Sci. 2016;20(2):269-77.
Title: MiR-874 inhibits cell growth and induces apoptosis by targeting STAT3 in human colorectal cancer cells.
Author: Zhao, B|Dong, A-S
PMID: 26875895
Journal: Cancer Res. 2016 Apr 15;76(8):2115-24.
Title: Redundant Innate and Adaptive Sources of IL17 Production Drive Colon Tumorigenesis.
Author: Housseau, Franck|Wu, Shaoguang|Wick, Elizabeth C|Fan, Hongni|Wu, Xinqun|Llosa, Nicolas J|Smith, Kellie N|Tam, Ada|Ganguly, Sudipto|Wanyiri, Jane W|Iyadorai, Thevambiga|Malik, Ausama A|Roslani, April C|Vadivelu, Jamunarani S|Van Meerbeke, Sara|Huso, David
PMID: 26880802
Journal: Oncotarget. 2016 Mar 15;7(11):12917-26.
Title: A novel small molecule STAT3 inhibitor, LY5, inhibits cell viability, colony formation, and migration of colon and liver cancer cells.
Author: Zhao, Chongqiang|Wang, Wenlong|Yu, Wenying|Jou, David|Wang, Yina|Ma, Haiyan|Xiao, Hui|Qin, Hua|Zhang, Cuntai|Lu, Jiagao|Li, Sheng|Li, Chenglong|Lin, Jiayuh|Lin, Li
PMID: 26883202
Journal: Inflamm Bowel Dis. 2016 May;22(5):1107-18.
Title: PDCD4 Deficiency Aggravated Colitis and Colitis-associated Colorectal Cancer Via Promoting IL-6/STAT3 Pathway in Mice.
Author: Wang, Liyang|Zhao, Mingsheng|Guo, Chun|Wang, Guannan|Zhu, Faliang|Wang, Jianing|Wang, Xiaoyan|Wang, Qun|Zhao, Wei|Shi, Yongyu|Chen, Youhai H|Zhang, Lining
PMID: 26891257
Journal: BMC Cancer. 2016 Feb 19;16:126.
Title: Combination of metformin and 5-aminosalicylic acid cooperates to decrease proliferation and induce apoptosis in colorectal cancer cell lines.
Author: Saber, Mona M|Galal, May A|Ain-Shoka, Afaf A|Shouman, Samia A
PMID: 26896068
Journal: Genome Biol. 2016 Feb 22;17:24.
Title: The aspirin-induced long non-coding RNA OLA1P2 blocks phosphorylated STAT3 homodimer formation.
Author: Guo, Haiyan|Liu, Jun|Ben, Qiwen|Qu, Yuehong|Li, Man|Wang, Ying|Chen, Wantao|Zhang, Jianjun
PMID: 26898989
Journal: Cancer Cell. 2016 Mar 14;29(3):354-366.
Title: Smyd3 Is a Transcriptional Potentiator of Multiple Cancer-Promoting Genes and Required for Liver and Colon Cancer Development.
Author: Sarris, Michalis E|Moulos, Panagiotis|Haroniti, Anna|Giakountis, Antonis|Talianidis, Iannis
PMID: 26908355
Journal: Cancer Lett. 2016 Jun 1;375(2):209-220.
Title: Jak-STAT3 pathway triggers DICER1 for proteasomal degradation by ubiquitin ligase complex of CUL4A(DCAF1) to promote colon cancer development.
Author: Ren, Weiguo|Shen, Shourong|Sun, Zhenqiang|Shu, Peng|Shen, Xiaohua|Bu, Chibin|Ai, Feiyan|Zhang, Xuemei|Tang, Anliu|Tian, Li|Li, Guiyuan|Li, Xiayu|Ma, Jian
PMID: 26965998
Journal: Cell Rep. 2016 Mar 22;14(11):2562-75.
Title: The Innate Immune Receptor NLRX1 Functions as a Tumor Suppressor by Reducing Colon Tumorigenesis and Key Tumor-Promoting Signals.
Author: Koblansky, A Alicia|Truax, Agnieszka D|Liu, Rongrong|Montgomery, Stephanie A|Ding, Shengli|Wilson, Justin E|Brickey, W June|Muhlbauer, Marcus|McFadden, Rita-Marie T|Hu, Peizhen|Li, Zengshan|Jobin, Christian|Lund, Pauline Kay|Ting, Jenny P-Y
PMID: 26971998
Journal: Gene. 2016 Jun 10;584(1):75-82.
Title: STAT3-dependent TXNDC17 expression mediates Taxol resistance through inducing autophagy in human colorectal cancer cells.
Author: Zhang, Zhongde|Wang, Aihua|Li, Hui|Zhi, Hui|Lu, Feng
PMID: 26976343
Journal: Curr Med Chem. 2016;23(11):1171-84.
Title: Non-Photoinduced Biological Properties of Verteporfin.
Author: Gibault, Floriane|Corvaisier, Matthieu|Bailly, Fabrice|Huet, Guillemette|Melnyk, Patricia|Cotelle, Philippe
PMID: 26980565
Journal: Mol Cancer Res. 2016 Jun;14(6):563-73.
Title: Kinase-Dependent and -Independent Roles for PTK6 in Colon Cancer.
Author: Mathur, Priya S|Gierut, Jessica J|Guzman, Grace|Xie, Hui|Xicola, Rosa M|Llor, Xavier|Chastkofsky, Michael I|Perekatt, Ansu O|Tyner, Angela L
PMID: 26983689
Journal: Mediators Inflamm. 2016;2016:8026494.
Title: IL-6 Inhibition Reduces STAT3 Activation and Enhances the Antitumor Effect of Carboplatin.
Author: Wang, Zhi-Yong|Zhang, Jun-Ai|Wu, Xian-Jin|Liang, Yan-Fang|Lu, Yuan-Bin|Gao, Yu-Chi|Dai, You-Chao|Yu, Shi-Yan|Jia, Yan|Fu, Xiao-Xia|Rao, Xiaoquan|Xu, Jun-Fa|Zhong, Jixin
PMID: 27006530
Journal: Oncotarget. 2016 May 3;7(18):26780-92.
Title: Tumor suppressor PRSS8 targets Sphk1/S1P/Stat3/Akt signaling in colorectal cancer.
Author: Bao, Yonghua|Li, Kai|Guo, Yongchen|Wang, Qian|Li, Zexin|Yang, Yiqiong|Chen, Zhiguo|Wang, Jianguo|Zhao, Weixing|Zhang, Huijuan|Chen, Jiwang|Dong, Huali|Shen, Kui|Diamond, Alan M|Yang, Wancai
PMID: 27050145
Journal: BBA Clin. 2015 Nov 5;5:16-24.
Title: Inflammatory bowel disease, colorectal cancer and type 2 diabetes mellitus: The links.
Author: Jurjus, Abdo|Eid, Assad|Al Kattar, Sahar|Zeenny, Marie Noel|Gerges-Geagea, Alice|Haydar, Hanine|Hilal, Anis|Oueidat, Doreid|Matar, Michel|Tawilah, Jihane|Hussein, Inaya Hajj|Schembri-Wismayer, Pierre|Cappello, Francesco|Tomasello, Giovanni|Leone, Angelo|J
PMID: 27051585
Journal: Mol Ther. 2016 Aug;24(7):1199-215.
Title: CRNDE Promotes Malignant Progression of Glioma by Attenuating miR-384/PIWIL4/STAT3 Axis.
Author: Zheng, Jian|Liu, Xiaobai|Wang, Ping|Xue, Yixue|Ma, Jun|Qu, Chengbin|Liu, Yunhui
PMID: 27058823
Journal: Mol Med Rep. 2016 Jun;13(6):5276-82.
Title: Oleanolic acid inhibits colorectal cancer angiogenesis in vivo and in vitro via suppression of STAT3 and Hedgehog pathways.
Author: Li, Li|Lin, Jiumao|Sun, Guodong|Wei, Lihui|Shen, Aling|Zhang, Mingyue|Peng, Jun
PMID: 27108756
Journal: Nutrients. 2016 May 2;8(5). pii: nu8050261.
Title: Chemopreventive Effect of Dietary Glutamineon Colitis-Associated Colorectal Cancer Is Associated with Modulation of the DEPTOR/mTOR Signaling Pathway.
Author: Tian, Yun|Wang, Keming|Fan, Yingrui|Wang, Yan|Sun, Liqun|Wang, Li|Wang, Jirong|Wang, Zhaoxia|Li, Juan|Ye, Ying|Ji, Guozhong
PMID: 27144580
Journal: Oncotarget. 2016 Jun 14;7(24):36501-36509.
Title: BRG1 targeting STAT3/VEGFC signaling regulates lymphangiogenesis in colorectal cancer.
Author: Zhu, Xu|Sun, Li|Lan, Jingqin|Xu, Linli|Zhang, Meng|Luo, Xuelai|Gong, Jianping|Wang, Guihua|Yuan, Xianglin|Hu, Junbo|Wang, Jing
PMID: 27145366
Journal: Cancer Cell. 2016 May 9;29(5):684-696.
Title: IRAK-M Expression in Tumor Cells Supports Colorectal Cancer Progression through Reduction of Antimicrobial Defense and Stabilization of STAT3.
Author: Kesselring, Rebecca|Glaesner, Joachim|Hiergeist, Andreas|Naschberger, Elisabeth|Neumann, Helmut|Brunner, Stefan M|Wege, Anja K|Seebauer, Caroline|Kohl, Gudrun|Merkl, Susanne|Croner, Roland S|Hackl, Christina|Sturzl, Michael|Neurath, Markus F|Gessner, Andr
PMID: 27150039
Journal: Food Funct. 2016 May 18;7(5):2409-19.
Title: Dietary peptides from the non-digestible fraction of Phaseolus vulgaris L. decrease angiotensin II-dependent proliferation in HCT116 human colorectal cancer cells through the blockade of the renin-angiotensin system.
Author: Luna-Vital, Diego A|Liang, Katie|Gonzalez de Mejia, Elvira|Loarca-Pina, Guadalupe
PMID: 27156533
Journal: Cancer Cell. 2016 May 9;29(5):615-617.
Title: Multifaceted Role of IRAK-M in the Promotion of Colon Carcinogenesis via Barrier Dysfunction and STAT3 Oncoprotein Stabilization in Tumors.
Author: Jenkins, Brendan J
PMID: 27165738
Journal: Oncotarget. 2016 Aug 9;7(32):51096-51106.
Title: The ratio of STAT1 to STAT3 expression is a determinant of colorectal cancer growth.
Author: Nivarthi, Harini|Gordziel, Claire|Themanns, Madeleine|Kramer, Nina|Eberl, Markus|Rabe, Bjorn|Schlederer, Michaela|Rose-John, Stefan|Knosel, Thomas|Kenner, Lukas|Freund, Patricia|Aberger, Fritz|Han, Xiaonan|Kralovics, Robert|Dolznig, Helmut|Jennek, Susanne
PMID: 27191495
Journal: Sci Rep. 2016 May 20;6:26524.
Title: The long noncoding RNA CASC2 functions as a competing endogenous RNA by sponging miR-18a in colorectal cancer.
Author: Huang, Guanli|Wu, Xiaoli|Li, Shi|Xu, Xiaoqun|Zhu, Hua|Chen, Xiangjian
PMID: 27198161
Journal: Carcinogenesis. 2016 Aug;37(8):777-786.
Title: Keratin 8-deletion induced colitis predisposes to murine colorectal cancer enforced by the inflammasome and IL-22 pathway.
Author: Misiorek, Julia O|Lahdeniemi, Iris A K|Nystrom, Joel H|Paramonov, Valeriy M|Gullmets, Josef A|Saarento, Helena|Rivero-Muller, Adolfo|Husoy, Trine|Taimen, Pekka|Toivola, Diana M
PMID: 27234655
Journal: Neoplasia. 2016 May;18(5):307-316.
Title: Salmonella Protein AvrA Activates the STAT3 Signaling Pathway in Colon Cancer.
Author: Lu, Rong|Wu, Shaoping|Zhang, Yong-Guo|Xia, Yinglin|Zhou, Zhongren|Kato, Ikuko|Dong, Hui|Bissonnette, Marc|Sun, Jun
PMID: 27237322
Journal: Mediators Inflamm. 2016;2016:3214105.
Title: Epstein-Barr Virus-Induced Gene 3 (EBI3) Blocking Leads to Induce Antitumor Cytotoxic T Lymphocyte Response and Suppress Tumor Growth in Colorectal Cancer by Bidirectional Reciprocal-Regulation STAT3 Signaling Pathway.
Author: Liang, Yanfang|Chen, Qianqian|Du, Wenjing|Chen, Can|Li, Feifei|Yang, Jingying|Peng, Jianyu|Kang, Dongping|Lin, Bihua|Chai, Xingxing|Zhou, Keyuan|Zeng, Jincheng
PMID: 27247488
Journal: Eur Rev Med Pharmacol Sci. 2016 May;20(10):2028-37.
Title: Upregulated STAT3 and RhoA signaling in colorectal cancer (CRC) regulate the invasion and migration of CRC cells.
Author: Zhang, G-Y|Yang, W-H|Chen, Z
PMID: 27249601
Journal: PLoS One. 2016 Jun 6;11(6):e0156871.
Title: MiR-205 and MiR-373 Are Associated with Aggressive Human Mucinous Colorectal Cancer.
Author: Eyking, Annette|Reis, Henning|Frank, Magdalena|Gerken, Guido|Schmid, Kurt W|Cario, Elke
PMID: 27271572
Journal: Gastroenterol Res Pract. 2016;2016:3521453.
Title: Annexin A2 Coordinates STAT3 to Regulate the Invasion and Migration of Colorectal Cancer Cells In Vitro.
Author: Xiu, Dianhui|Liu, Lin|Qiao, Fengli|Yang, Haishan|Cui, Lu|Liu, Guifeng
PMID: 27274723
Journal: Int J Oncol. 2016 Aug;49(2):487-98.
Title: Combination treatment with flavonoid morin and telomerase inhibitor MST312 reduces cancer stem cell traits by targeting STAT3 and telomerase.
Author: Chung, Seyung S|Oliva, Bryant|Dwabe, Sami|Vadgama, Jaydutt V
PMID: 27279256
Journal: Nat Commun. 2016 Jun 16;7:11798.
Title: Suspension survival mediated by PP2A-STAT3-Col XVII determines tumour initiation and metastasis in cancer stem cells.
Author: Liu, Chen-Chi|Lin, Shih-Pei|Hsu, Han-Shui|Yang, Shung-Haur|Lin, Chiu-Hua|Yang, Muh-Hwa|Hung, Mien-Chie|Hung, Shih-Chieh
PMID: 27306323
Journal: Mol Cell Biochem. 2016 Jul;418(1-2):189-98.
Title: Valosin-containing protein (VCP) promotes the growth, invasion, and metastasis of colorectal cancer through activation of STAT3 signaling.
Author: Fu, Qianfeng|Jiang, Yuling|Zhang, Daxin|Liu, Xiuli|Guo, Junfeng|Zhao, Jinlong
PMID: 27344168
Journal: Oncotarget. 2016 Jul 19;7(29):46384-46400.
Title: Critical function of the necroptosis adaptor RIPK3 in protecting from intestinal tumorigenesis.
Author: Bozec, Dominique|Iuga, Alina C|Roda, Giulia|Dahan, Stephanie|Yeretssian, Garabet
PMID: 27344176
Journal: Zhonghua Wei Chang Wai Ke Za Zhi. 2016 Jun;19(6):695-701.
Title: [Effect of interleukin 17 on invasion of human colon cancer cells].
Author: Chen, Zhuanpeng|Cao, Jie|Yang, Ping|Liu, Zhenbang|Wei, Jianchang|Chen, Huacui|Qiu, Xubin|Hu, He
PMID: 27353107
Journal: Oncotarget. 2016 Aug 2;7(31):49848-49858.
Title: Histone deacetylase inhibitors regulate P-gp expression in colorectal cancer via transcriptional activation and mRNA stabilization.
Author: Wang, Hao|Huang, Cheng|Zhao, Liang|Zhang, Huan|Yang, Jing Mo|Luo, Peng|Zhan, Bing-Xiang|Pan, Qing|Li, Jun|Wang, Bao-Long
PMID: 27409663
Journal: Arch Med Res. 2016 Apr;47(3):214-22.
Title: Aberrant Expression of CUL4A Is Associated with IL-6/ STAT3 Activation in Colorectal Cancer Progression.
Author: Ren, Weiguo|Sun, Zhenqiang|Zeng, Qinglei|Han, Shuang|Zhang, Qinglin|Jiang, Libin
PMID: 27418574
Journal: Oncol Rep. 2016 Sep;36(3):1411-8.
Title: RNA interference against TRIM29 inhibits migration and invasion of colorectal cancer cells.
Author: Xu, Weihong|Xu, Bin|Yao, Yiting|Yu, Xiaoling|Cao, Hua|Zhang, Jun|Liu, Jie|Sheng, Huiming
PMID: 27430345
Journal: Oncotarget. 2016 Sep 27;7(39):63093-63105.
Title: Visceral fat adipocytes from obese and colorectal cancer subjects exhibit distinct secretory and omega6 polyunsaturated fatty acid profiles and deliver immunosuppressive signals to innate immunity cells.
Author: Del Corno, Manuela|D'Archivio, Massimo|Conti, Lucia|Scazzocchio, Beatrice|Vari, Rosaria|Donninelli, Gloria|Varano, Barbara|Giammarioli, Stefania|De Meo, Simone|Silecchia, Gianfranco|Pennestri, Francesco|Persiani, Roberto|Masella, Roberta|Gessani, Sandra
PMID: 27494857
Journal: Oncotarget. 2016 Aug 23;7(34):55663-55676.
Title: CD24 promoted cancer cell angiogenesis via Hsp90-mediated STAT3/VEGF signaling pathway in colorectal cancer.
Author: Wang, Xinying|Zhang, Yu|Zhao, Yingying|Liang, Yanling|Xiang, Cheng|Zhou, Huanyu|Zhang, Hui|Zhang, Qiang|Qing, Haitao|Jiang, Bo|Xiong, Huabao|Peng, Liang
PMID: 27494878
Journal: PLoS One. 2016 Aug 9;11(8):e0160125.
Title: The Role of p-STAT3 as a Prognostic and Clinicopathological Marker in Colorectal Cancer: A Systematic Review and Meta-Analysis.
Author: Ji, Kun|Zhang, Mingxuan|Chu, Qi|Gan, Yong|Ren, Hui|Zhang, Liyan|Wang, Liwei|Li, Xiaoxiu|Wang, Wei
PMID: 27504822
Journal: Oncotarget. 2016 Sep 27;7(39):63124-63137.
Title: DDA suppresses angiogenesis and tumor growth of colorectal cancer in vivo through decreasing VEGFR2 signaling.
Author: Huang, Shiu-Wen|Lien, Jin-Cherng|Kuo, Sheng-Chu|Huang, Tur-Fu
PMID: 27517319
Journal: Oncotarget. 2016 Sep 13;7(37):59766-59780.
Title: Carcinoma-associated fibroblasts affect sensitivity to oxaliplatin and 5FU in colorectal cancer cells.
Author: Goncalves-Ribeiro, Samuel|Diaz-Maroto, Natalia Guillen|Berdiel-Acer, Mireia|Soriano, Antonio|Guardiola, Jordi|Martinez-Villacampa, Mercedes|Salazar, Ramon|Capella, Gabriel|Villanueva, Alberto|Martinez-Balibrea, Eva|Mollevi, David G
PMID: 27517495
Journal: Cell Metab. 2016 Sep 13;24(3):447-461.
Title: Iron Uptake via DMT1 Integrates Cell Cycle with JAK-STAT3 Signaling to Promote Colorectal Tumorigenesis.
Author: Xue, Xiang|Ramakrishnan, Sadeesh K|Weisz, Kevin|Triner, Daniel|Xie, Liwei|Attili, Durga|Pant, Asha|Gyorffy, Balazs|Zhan, Mingkun|Carter-Su, Christin|Hardiman, Karin M|Wang, Thomas D|Dame, Michael K|Varani, James|Brenner, Dean|Fearon, Eric R|Shah, Yatrik M
PMID: 27546461
Journal: J Ethnopharmacol. 2016 Dec 24;194:83-90.
Title: Ginsenoside 20(S)-Rh2 exerts anti-cancer activity through targeting IL-6-induced JAK2/STAT3 pathway in human colorectal cancer cells.
Author: Han, Songhee|Jeong, Ae Jin|Yang, Heejung|Bin Kang, Kyo|Lee, Haeri|Yi, Eun Hee|Kim, Byung-Hak|Cho, Chung-Hyun|Chung, Jin Woong|Sung, Sang Hyun|Ye, Sang-Kyu
PMID: 27566200
Journal: Mol Med Rep. 2016 Oct;14(4):3059-65.
Title: Overexpression of gelsolin reduces the proliferation and invasion of colon carcinoma cells.
Author: Li, Wen-Xiang|Yang, Meng-Xuan|Hong, Xin-Qiang|Dong, Tian-Geng|Yi, Tuo|Lin, Sheng-Li|Qin, Xin-Yu|Niu, Wei-Xin
PMID: 27573444
Journal: Oncotarget. 2016 Oct 4;7(40):65676-65695.
Title: SHP-2 phosphatase contributes to KRAS-driven intestinal oncogenesis but prevents colitis-associated cancer development.
Author: Gagne-Sansfacon, Jessica|Coulombe, Genevieve|Langlois, Marie-Josee|Langlois, Ariane|Paquet, Marilene|Carrier, Julie|Feng, Gen-Sheng|Qu, Cheng-Kui|Rivard, Nathalie
PMID: 27582544
Journal: Oncoimmunology. 2015 Sep 2;5(8):e1082704.
Title: Th22 cells control colon tumorigenesis through STAT3 and Polycomb Repression complex 2 signaling.
Author: Sun, Danfeng|Lin, Yanwei|Hong, Jie|Chen, Haoyan|Nagarsheth, Nisha|Peng, Dongjun|Wei, Shuang|Huang, Emina|Fang, Jingyuan|Kryczek, Ilona|Zou, Weiping
PMID: 27622053
Journal: Protein Cell. 2016 Oct;7(10):722-734.
Title: miR-181b functions as an oncomiR in colorectal cancer by targeting PDCD4.
Author: Liu, Yanqing|Uzair-Ur-Rehman|Guo, Yu|Liang, Hongwei|Cheng, Rongjie|Yang, Fei|Hong, Yeting|Zhao, Chihao|Liu, Minghui|Yu, Mengchao|Zhou, Xinyan|Yin, Kai|Chen, Jiangning|Zhang, Junfeng|Zhang, Chen-Yu|Zhi, Feng|Chen, Xi
PMID: 27647131
Journal: Adv Exp Med Biol. 2016;928:435-452.
Title: Garcinol and Its Role in Chronic Diseases.
Author: Behera, Amit K|Swamy, Mahadeva M|Natesh, Nagashayana|Kundu, Tapas K
PMID: 27671827
Journal: Oncotarget. 2016 Nov 8;7(45):73003-73015.
Title: Elevated level of interleukin-35 in colorectal cancer induces conversion of T cells into iTr35 by activating STAT1/STAT3.
Author: Ma, Yanhui|Chen, Lei|Xie, Guohua|Zhou, Yunlan|Yue, Chaoyan|Yuan, Xiangliang|Zheng, Yingxia|Wang, Weiwei|Deng, Lin|Shen, Lisong
PMID: 27682874
Journal: Gastroenterol Res Pract. 2016;2016:2102674.
Title: Reduced Representation Bisulfite Sequencing Determination of Distinctive DNA Hypermethylated Genes in the Progression to Colon Cancer in African Americans.
Author: Ashktorab, Hassan|Shakoori, Afnan|Zarnogi, Shatha|Sun, Xueguang|Varma, Sudhir|Lee, Edward|Shokrani, Babak|Laiyemo, Adeyinka O|Washington, Kareem|Brim, Hassan
PMID: 27688749
Journal: BMC Cancer. 2016 Oct 12;16(1):791.
Title: Combined application of anti-VEGF and anti-EGFR attenuates the growth and angiogenesis of colorectal cancer mainly through suppressing AKT and ERK signaling in mice model.
Author: Ding, Chenbo|Li, Longmei|Yang, Taoyu|Fan, Xiaobo|Wu, Guoqiu
PMID: 27729020
Journal: J Huazhong Univ Sci Technolog Med Sci. 2016 Oct;36(5):677-682.
Title: Foxp3 expression in CD4(+)CD25(+)Foxp3(+) regulatory T cells promotes development of colorectal cancer by inhibiting tumor immunity.
Author: Zhu, Xiao-Wen|Zhu, Hai-Zhen|Zhu, You-Qing|Feng, Mao-Hui|Qi, Jian|Chen, Zhi-Fen
PMID: 27752897
Journal: Biochem Biophys Res Commun. 2016 Nov 25;480(4):528-533.
Title: microRNA-146a inhibits proliferation, migration and invasion of human cervical and colorectal cancer cells.
Author: Sathyanarayanan, Anusha|Chandrasekaran, Karthik Subramanian|Karunagaran, Devarajan
PMID: 27769860
Journal: PLoS One. 2016 Nov 8;11(11):e0165912.
Title: miR-146a Polymorphism (rs2910164) Predicts Colorectal Cancer Patients' Susceptibility to Liver Metastasis.
Author: Iguchi, Tomohiro|Nambara, Sho|Masuda, Takaaki|Komatsu, Hisateru|Ueda, Masami|Kidogami, Shinya|Ogawa, Yushi|Hu, Qingjiang|Sato, Kuniaki|Saito, Tomoko|Hirata, Hidenari|Sakimura, Shotaro|Uchi, Ryutaro|Hayashi, Naoki|Ito, Shuhei|Eguchi, Hidetoshi|Sugimachi, K
PMID: 27824903
Journal: Hawaii J Med Public Health. 2016 Nov;75(11):353-359.
Title: The Daniel K. Inouye College of Pharmacy Scripts: Poha Berry (Physalis peruviana) with Potential Anti-inflammatory and Cancer Prevention Activities.
Author: Chang, Leng Chee|Sang-Ngern, Mayuramas|Pezzuto, John M|Ma, Carolyn
PMID: 27920947
Journal: Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2016 Dec 28;41(12):1297-1304.
Title: [Effect of jianpi-jiedu formula on tumor angiogenesis-relevant genes expression in colorectal cancer].
Author: Mao, Dan|Lei, Sanlin|Ma, Jin'an|Shi, Li|Zhang, Shaofan|Huang, Jianhua|Liu, Xinyi|Ding, Dengfeng|Zhang, Yingjin|Feng, Lei|Zhang, Sifang
PMID: 28070042
Journal: Mol Carcinog. 2017 Jan;56(1):172-183.
Title: delta- and gamma-tocopherols inhibit phIP/DSS-induced colon carcinogenesis by protection against early cellular and DNA damages.
Author: Chen, Jayson X|Liu, Anna|Lee, Mao-Jung|Wang, Hong|Yu, Siyuan|Chi, Eric|Reuhl, Kenneth|Suh, Nanjoo|Yang, Chung S
PMID: 27175800
Journal: Cell Mol Immunol. 2017 Jan;14(1):127-142.
Title: The AIM2 inflammasome is a central regulator of intestinal homeostasis through the IL-18/IL-22/STAT3 pathway.
Author: Ratsimandresy, Rojo A|Indramohan, Mohanalaxmi|Dorfleutner, Andrea|Stehlik, Christian
PMID: 27524110
Journal: Oncogene. 2017 Feb 23;36(8):1069-1079.
Title: Stat3 contributes to cancer progression by regulating Jab1/Csn5 expression.
Author: Pan, Y|Wang, S|Su, B|Zhou, F|Zhang, R|Xu, T|Zhang, R|Leventaki, V|Drakos, E|Liu, W|Claret, F X
PMID: 27524414
Journal: Clin Cancer Res. 2017 Apr 1;23(7):1698-1709.
Title: Signal Transduction and Activator of Transcription-3 (STAT3) in Patients with Colorectal Cancer: Associations with the Phenotypic Features of the Tumor and Host.
Author: Park, James H|van Wyk, Hester|McMillan, Donald C|Quinn, Jean|Clark, Jennifer|Roxburgh, Campbell S D|Horgan, Paul G|Edwards, Joanne
PMID: 27678454
Journal: Biofactors. 2017 Mar;43(2):283-292.
Title: Cooperation between the bacterial-derived short-chain fatty acid butyrate and interleukin-22 detected in human Caco2 colon epithelial/carcinoma cells.
Author: Bachmann, Malte|Meissner, Carlotta|Pfeilschifter, Josef|Muhl, Heiko
PMID: 27801948
Journal: Oncogene. 2017 Apr 20;36(16):2328-2336.
Title: HSP110 promotes colorectal cancer growth through STAT3 activation.
Author: Berthenet, K|Bokhari, A'dem|Lagrange, A|Marcion, G|Boudesco, C|Causse, S|De Thonel, A|Svrcek, M|Goloudina, A R|Dumont, S|Hammann, A|Biard, D S|Demidov, O N|Seigneuric, R|Duval, A|Collura, A|Jego, G|Garrido, C
PMID: 27819670
Journal: Biomed Pharmacother. 2017 Jan;85:355-361.
Title: Silencing of long non-coding RNA SBDSP1 suppresses tumor growth and invasion in colorectal cancer.
Author: Shi, Debing|Liang, Lei|Zheng, Hongtu|Cai, Guoxiang|Li, Xinxiang|Xu, Ye|Cai, Sanjun
PMID: 27890432
Journal: Oncogene. 2017 Jun 1;36(22):3080-3093.
Title: The DEAD box protein p68: a novel coactivator of Stat3 in mediating oncogenesis.
Author: Sarkar, M|Khare, V|Ghosh, M K
PMID: 27941883
Journal: Mol Cancer Ther. 2017 Feb;16(2):300-311.
Title: Niclosamide Inhibits Oxaliplatin Neurotoxicity while Improving Colorectal Cancer Therapeutic Response.
Author: Cerles, Olivier|Benoit, Evelyne|Chereau, Christiane|Chouzenoux, Sandrine|Morin, Florence|Guillaumot, Marie-Anne|Coriat, Romain|Kavian, Niloufar|Loussier, Thomas|Santulli, Pietro|Marcellin, Louis|Saidu, Nathaniel E B|Weill, Bernard|Batteux, Frederic|Nicco,
PMID: 27980107
Journal: Cancer Lett. 2017 Mar 28;389:41-48.
Title: SRI36160 is a specific inhibitor of Wnt/beta-catenin signaling in human pancreatic and colorectal cancer cells.
Author: Li, Yonghe|Oliver, Patsy G|Lu, Wenyan|Pathak, Vibha|Sridharan, Sivaram|Augelli-Szafran, Corinne E|Buchsbaum, Donald J|Suto, Mark J
PMID: 28043913
Journal: Cell Death Dis. 2017 Jan 5;8(1):e2534.
Title: Inhibition of Stat3 signaling pathway by nifuroxazide improves antitumor immunity and impairs colorectal carcinoma metastasis.
Author: Ye, Ting-Hong|Yang, Fang-Fang|Zhu, Yong-Xia|Li, Ya-Li|Lei, Qian|Song, Xue-Jiao|Xia, Yong|Xiong, Ying|Zhang, Li-Dan|Wang, Ning-Yu|Zhao, Li-Feng|Gou, Hong-Feng|Xie, Yong-Mei|Yang, Sheng-Yong|Yu, Luo-Ting|Yang, Li|Wei, Yu-Quan
PMID: 28055016
Journal: J Exp Clin Cancer Res. 2017 Jan 5;36(1):2.
Title: RNA virus receptor Rig-I monitors gut microbiota and inhibits colitis-associated colorectal cancer.
Author: Zhu, Houbao|Xu, Wang-Yang|Hu, Zhiqiang|Zhang, Hongxin|Shen, Yan|Lu, Shunyuan|Wei, Chaochun|Wang, Zhu-Gang
PMID: 28057020
Journal: Prostaglandins Other Lipid Mediat. 2017 Sep;132:77-83.
Title: ALOX15 as a suppressor of inflammation and cancer: Lost in the link.
Author: Tian, Rui|Zuo, Xiangsheng|Jaoude, Jonathan|Mao, Fei|Colby, Jennifer|Shureiqi, Imad
PMID: 28089732
Journal: Exp Ther Med. 2017 Jan;13(1):49-54.
Title: Correlation between microvascular characteristics and the expression of MVD, IGF-1 and STAT3 in the development of colonic polyps carcinogenesis.
Author: Liu, Hong|Wu, Jing|Liu, Xiang-Chun|Wei, Nan|Liu, Kui-Liang|Ma, Yan-Hui|Chang, Hong|Zhou, Quan
PMID: 28123467
Journal: Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1643-1648.
Title: YAP-IL-6ST autoregulatory loop activated on APC loss controls colonic tumorigenesis.
Author: Taniguchi, Koji|Moroishi, Toshiro|de Jong, Petrus R|Krawczyk, Michal|Grebbin, Britta Moyo|Luo, Huiyan|Xu, Rui-Hua|Golob-Schwarzl, Nicole|Schweiger, Caroline|Wang, Kepeng|Di Caro, Giuseppe|Feng, Ying|Fearon, Eric R|Raz, Eyal|Kenner, Lukas|Farin, Henner F|G
PMID: 28130546
Journal: Biosci Trends. 2017 Mar 22;11(1):1-8.
Title: Steering of carcinoma progression by the YIN/YANG interaction of STAT1/STAT3.
Author: Friedrich, Karlheinz|Dolznig, Helmut|Han, Xiaonan|Moriggl, Richard
PMID: 28154246
Journal: Oncotarget. 2017 Apr 11;8(15):24762-24776.
Title: The oncoprotein gankyrin promotes the development of colitis-associated cancer through activation of STAT3.
Author: Sakurai, Toshiharu|Higashitsuji, Hiroaki|Kashida, Hiroshi|Watanabe, Tomohiro|Komeda, Yoriaki|Nagai, Tomoyuki|Hagiwara, Satoru|Kitano, Masayuki|Nishida, Naoshi|Abe, Takaya|Kiyonari, Hiroshi|Itoh, Katsuhiko|Fujita, Jun|Kudo, Masatoshi
PMID: 28160571
Journal: Anticancer Res. 2017 Feb;37(2):445-453.
Title: Salinomycin Abolished STAT3 and STAT1 Interactions and Reduced Telomerase Activity in Colorectal Cancer Cells.
Author: Chung, Seyung S|Adekoya, Debbie|Enenmoh, Ikechukwu|Clarke, Orette|Wang, Piwen|Sarkyssian, Marianna|Wu, Yong|Vadgama, Jaydutt V
PMID: 28179289
Journal: Oncotarget. 2017 Mar 7;8(10):16633-16641.
Title: microRNA-375 inhibits colorectal cancer cells proliferation by downregulating JAK2/STAT3 and MAP3K8/ERK signaling pathways.
Author: Wei, Ran|Yang, Qin|Han, Bing|Li, Yan|Yao, Kun|Yang, Xiuyu|Chen, Zexi|Yang, Shanshan|Zhou, Jiaqi|Li, Meizhang|Yu, Haijing|Yu, Min|Cui, Qinghua
PMID: 28186962
Journal: Mol Cell Endocrinol. 2017 Aug 15;451:80-87.
Title: STAT3 activation in infection and infection-associated cancer.
Author: Lu, Rong|Zhang, Yong-Guo|Sun, Jun
PMID: 28223148
Journal: Cell Death Dis. 2017 Feb 23;8(2):e2621.
Title: Oncogenic role of rab escort protein 1 through EGFR and STAT3 pathway.
Author: Yun, Un-Jung|Sung, Jee Young|Park, Seog-Yun|Ye, Sang-Kyu|Shim, Jaegal|Lee, Jae-Seon|Hibi, Masahiko|Bae, Young-Ki|Kim, Yong-Nyun
PMID: 28230863
Journal: J Cell Biochem. 2017 Sep;118(9):2958-2967.
Title: Lithocholic Acid Stimulates IL-8 Expression in Human Colorectal Cancer Cells Via Activation of Erk1/2 MAPK and Suppression of STAT3 Activity.
Author: Nguyen, Thi Thinh|Lian, Sen|Ung, Trong Thuan|Xia, Yong|Han, Jae Young|Jung, Young Do
PMID: 28247965
Journal: Cancer Biol Ther. 2017 Apr 3;18(4):237-244.
Title: Chronic inflammation confers to the metabolic reprogramming associated with tumorigenesis of colorectal cancer.
Author: Qu, Dingding|Shen, Liangliang|Liu, Shaoqing|Li, Huichen|Ma, Yongzheng|Zhang, Ruohan|Wu, Kaichun|Yao, Libo|Li, Jipeng|Zhang, Jian
PMID: 28278072
Journal: Immunol Invest. 2017 Apr;46(3):221-238.
Title: Immunomodulating and Immunoresistance Properties of Cancer-Initiating Cells: Implications for the Clinical Success of Immunotherapy.
Author: Maccalli, Cristina|Parmiani, Giorgio|Ferrone, Soldano
PMID: 28287848
Journal: Evid Based Complement Alternat Med. 2017;2017:5180707.
Title: Helicteric Acid, Oleanic Acid, and Betulinic Acid, Three Triterpenes from Helicteres angustifolia L., Inhibit Proliferation and Induce Apoptosis in HT-29 Colorectal Cancer Cells via Suppressing NF-kappaB and STAT3 Signaling.
Author: Su, Dan|Gao, Yu-Qiao|Dai, Wei-Bo|Hu, Ying|Wu, Yan-Fen|Mei, Quan-Xi
PMID: 28331523
Journal: PLoS One. 2017 Mar 28;12(3):e0174343.
Title: Syndecan-1 deficiency promotes tumor growth in a murine model of colitis-induced colon carcinoma.
Author: Binder Gallimidi, Adi|Nussbaum, Gabriel|Hermano, Esther|Weizman, Barak|Meirovitz, Amichay|Vlodavsky, Israel|Gotte, Martin|Elkin, Michael
PMID: 28350804
Journal: Onco Targets Ther. 2017 Mar 23;10:1767-1776.
Title: Niclosamide inhibition of STAT3 synergizes with erlotinib in human colon cancer.
Author: Shi, Lingyi|Zheng, Hailun|Hu, Wanle|Zhou, Bin|Dai, Xuanxuan|Zhang, Yi|Liu, Zhiguo|Wu, Xiaoping|Zhao, Chengguang|Liang, Guang
PMID: 28367059
Journal: Sci Rep. 2017 Apr 3;8:45751.
Title: Chitosan promotes cancer progression and stem cell properties in association with Wnt signaling in colon and hepatocellular carcinoma cells.
Author: Chang, Po-Hsiang|Sekine, Keisuke|Chao, Hsiao-Mei|Hsu, Shan-Hui|Chern, Edward
PMID: 28367998
Journal: J Immunol. 2017 May 15;198(10):4166-4177.
Title: 4PD Functionalized Dendrimers: A Flexible Tool for In Vivo Gene Silencing of Tumor-Educated Myeloid Cells.
Author: Zilio, Serena|Vella, Jennifer L|De la Fuente, Adriana C|Daftarian, Pirouz M|Weed, Donald T|Kaifer, Angel|Marigo, Ilaria|Leone, Kevin|Bronte, Vincenzo|Serafini, Paolo
PMID: 28396317
Journal: Gastroenterology. 2017 Jul;153(1):178-190.e10.
Title: EGFR in Tumor-Associated Myeloid Cells Promotes Development of Colorectal Cancer in Mice and Associates With Outcomes of Patients.
Author: Srivatsa, Sriram|Paul, Mariel C|Cardone, Claudia|Holcmann, Martin|Amberg, Nicole|Pathria, Paulina|Diamanti, Michaela A|Linder, Markus|Timelthaler, Gerald|Dienes, Hans P|Kenner, Lukas|Wrba, Fritz|Prager, Gerald W|Rose-John, Stefan|Eferl, Robert|Liguori, Gi
PMID: 28400195
Journal: Oncoimmunology. 2017 Feb 10;6(3):e1290034.
Title: Histidine decarboxylase (HDC)-expressing granulocytic myeloid cells induce and recruit Foxp3(+) regulatory T cells in murine colon cancer.
Author: Chen, Xiaowei|Takemoto, Yoshihiro|Deng, Huan|Middelhoff, Moritz|Friedman, Richard A|Chu, Timothy H|Churchill, Michael J|Ma, Yan|Nagar, Karan K|Tailor, Yagnesh H|Mukherjee, Siddhartha|Wang, Timothy C
PMID: 28405523
Journal: Int J Mol Sci. 2017 Apr 17;18(4). pii: ijms18040851.
Title: Impact of Acetazolamide, a Carbonic Anhydrase Inhibitor, on the Development of Intestinal Polyps in Min Mice.
Author: Noma, Nobuharu|Fujii, Gen|Miyamoto, Shingo|Komiya, Masami|Nakanishi, Ruri|Shimura, Misato|Tanuma, Sei-Ichi|Mutoh, Michihiro
PMID: 28420165
Journal: Gastroenterology. 2017 Aug;153(2):505-520.
Title: Antagonistic Effects of p53 and HIF1A on microRNA-34a Regulation of PPP1R11 and STAT3 and Hypoxia-induced Epithelial to Mesenchymal Transition in Colorectal Cancer Cells.
Author: Li, Huihui|Rokavec, Matjaz|Jiang, Longchang|Horst, David|Hermeking, Heiko
PMID: 28435028
Journal: Cell Signal. 2017 Aug;36:67-78.
Title: Identification of NCK1 as a novel downstream effector of STAT3 in colorectal cancer metastasis and angiogenesis.
Author: Zhang, Fan|Lu, Yan-Xia|Chen, Qing|Zou, Hui-Mei|Zhang, Jian-Ming|Hu, Yu-Han|Li, Xiao-Min|Zhang, Wen-Juan|Zhang, Wei|Lin, Chun|Li, Xue-Nong
PMID: 28455144
Journal: Mol Oncol. 2017 Aug;11(8):1065-1077.
Title: Panitumumab interaction with TAS-102 leads to combinational anticancer effects via blocking of EGFR-mediated tumor response to trifluridine.
Author: Baba, Yuji|Tamura, Toshiya|Satoh, Yoshihiko|Gotou, Masamitsu|Sawada, Hiroshi|Ebara, Shunsuke|Shibuya, Kazunori|Soeda, Jumpei|Nakamura, Kazuhide
PMID: 28486761
Journal: Oncol Rep. 2017 Jun;37(6):3227-3234.
Title: MicroRNA-1299 is a negative regulator of STAT3 in colon cancer.
Author: Wang, Yong|Lu, Zhi|Wang, Ningning|Zhang, Man|Zeng, Xiandong|Zhao, Wei
PMID: 28498395
Journal: Biomed Pharmacother. 2017 Aug;92:384-393.
Title: Lactobacillus rhamnosus ATCC 7469 exopolysaccharides synergizes with low level ionizing radiation to modulate signaling molecular targets in colorectal carcinogenesis in rats.
Author: Zahran, Walid E|Elsonbaty, Sawsan M|Moawed, Fatma S M
PMID: 28554134
Journal: Oncol Rep. 2017 Jul;38(1):253-262.
Title: Silencing of type Igamma phosphatidylinositol phosphate kinase suppresses ovarian cancer cell proliferation, migration and invasion.
Author: Cao, Siyu|Chen, Chunhua|Xue, Junli|Huang, Yan|Yang, Xiaofeng|Ling, Kun
PMID: 28560454
Journal: Eur J Immunol. 2017 Aug;47(8):1342-1353.
Title: Card9-dependent IL-1beta regulates IL-22 production from group 3 innate lymphoid cells and promotes colitis-associated cancer.
Author: Bergmann, Hanna|Roth, Susanne|Pechloff, Konstanze|Kiss, Elina A|Kuhn, Sabine|Heikenwalder, Mathias|Diefenbach, Andreas|Greten, Florian R|Ruland, Jurgen
PMID: 28586167
Journal: Oncotarget. 2017 Jul 25;8(30):49807-49823.
Title: Maintenance of cancer stemness by miR-196b-5p contributes to chemoresistance of colorectal cancer cells via activating STAT3 signaling pathway.
Author: Ren, Dong|Lin, Bihua|Zhang, Xin|Peng, Yao|Ye, Ziyu|Ma, Yan|Liang, Yangfang|Cao, Longbin|Li, Xiangyong|Li, Ronggang|Sun, Lixia|Liu, Qiongru|Wu, Jinhua|Zhou, Keyuan|Zeng, Jincheng
PMID: 28591704
Journal: Gene. 2017 Sep 5;627:114-122.
Title: Prognostic significance of SOCS3 and its biological function in colorectal cancer.
Author: Chu, Qinjun|Shen, Dan|He, Long|Wang, Hongwei|Liu, Chunlan|Zhang, Wei
PMID: 28603075
Journal: Mol Carcinog. 2017 Nov;56(11):2434-2445.
Title: CRH promotes human colon cancer cell proliferation via IL-6/JAK2/STAT3 signaling pathway and VEGF-induced tumor angiogenesis.
Author: Fang, Xianjun|Hong, Yali|Dai, Li|Qian, Yuanyuan|Zhu, Chao|Wu, Biao|Li, Shengnan
PMID: 28618089
Journal: Int J Oncol. 2017 Aug;51(2):615-624.
Title: 18 beta-glycyrrhetinic acid exhibits potent antitumor effects against colorectal cancer via inhibition of cell proliferation and migration.
Author: Wang, Saisai|Shen, Yong|Qiu, Runfeng|Chen, Zhiliang|Chen, Zhehang|Chen, Wenbin
PMID: 28656212
Journal: Oncol Rep. 2017 Aug;38(2):926-932.
Title: Cetuximab promotes SN38 sensitivity via suppression of heat shock protein 27 in colorectal cancer cells with wild-type RAS.
Author: Ishida, Takashi|Ishii, Yoshiyuki|Tsuruta, Masashi|Okabayashi, Koji|Akimoto, Shingo|Koishikawa, Kaoru|Hasegawa, Hirotoshi|Kitagawa, Yuko
PMID: 28656305
Journal: Mediators Inflamm. 2017;2017:5958429.
Title: Proinflammatory Cytokines IL-6 and TNF-alpha Increased Telomerase Activity through NF-kappaB/STAT1/STAT3 Activation, and Withaferin A Inhibited the Signaling in Colorectal Cancer Cells.
Author: Chung, Seyung S|Wu, Yong|Okobi, Quincy|Adekoya, Debbie|Atefi, Mohammad|Clarke, Orette|Dutta, Pranabananda|Vadgama, Jaydutt V
PMID: 28676732
Journal: Sci Rep. 2017 Jul 5;7(1):4687.
Title: Pan-cancer EMT-signature identifies RBM47 down-regulation during colorectal cancer progression.
Author: Rokavec, Matjaz|Kaller, Markus|Horst, David|Hermeking, Heiko
PMID: 28680090
Journal: Stem Cell Reports. 2017 Aug 8;9(2):438-450.
Title: RBP4-STRA6 Pathway Drives Cancer Stem Cell Maintenance and Mediates High-Fat Diet-Induced Colon Carcinogenesis.
Author: Karunanithi, Sheelarani|Levi, Liraz|DeVecchio, Jennifer|Karagkounis, George|Reizes, Ofer|Lathia, Justin D|Kalady, Matthew F|Noy, Noa
PMID: 28689994
Journal: Biochem Biophys Res Commun. 2017 Sep 9;491(1):159-165.
Title: Inhibition of IL-6/STAT3 signaling in human cancer cells using Evista.
Author: Shi, Wei|Yan, Dan|Zhao, Chongqiang|Xiao, Miaomiao|Wang, Yina|Ma, Haiyan|Liu, Tianshu|Qin, Hua|Zhang, Cuntai|Li, Chenglong|Lin, Jiayuh|Li, Sheng|Lv, Jiagao|Lin, Li
PMID: 28711499
Journal: Nutr Cancer. 2017 Aug-Sep;69(6):855-861.
Title: Anticarcinogenic Effects of Dried Citrus Peel in Colon Carcinogenesis Due to Inhibition of Oxidative Stress.
Author: Onuma, Wakana|Asai, Daichi|Tomono, Susumu|Miyamoto, Shingo|Fujii, Gen|Hamoya, Takahiro|Nagano, Aya|Takahashi, Satoru|Masumori, Shoji|Miyoshi, Noriyuki|Wakabayashi, Keiji|Mutoh, Michihiro
PMID: 28718722
Journal: Sci Rep. 2017 Jul 19;7(1):5823.
Title: Mucin 2 silencing promotes colon cancer metastasis through interleukin-6 signaling.
Author: Hsu, Hui-Ping|Lai, Ming-Derg|Lee, Jenq-Chang|Yen, Meng-Chi|Weng, Tzu-Yang|Chen, Wei-Ching|Fang, Jung-Hua|Chen, Yi-Ling
PMID: 28725043
Journal: Cancer Sci. 2017 Oct;108(10):1947-1952.
Title: Interleukin-6/STAT3 signaling as a promising target to improve the efficacy of cancer immunotherapy.
Author: Kitamura, Hidemitsu|Ohno, Yosuke|Toyoshima, Yujiro|Ohtake, Junya|Homma, Shigenori|Kawamura, Hideki|Takahashi, Norihiko|Taketomi, Akinobu
PMID: 28749573
Journal: Oncogene. 2017 Nov 23;36(47):6592-6604.
Title: Loss of claudin-3 expression induces IL6/gp130/Stat3 signaling to promote colon cancer malignancy by hyperactivating Wnt/beta-catenin signaling.
Author: Ahmad, R|Kumar, B|Chen, Z|Chen, X|Muller, D|Lele, S M|Washington, M K|Batra, S K|Dhawan, P|Singh, A B
PMID: 28783170
Journal: Mol Cancer. 2017 Aug 7;16(1):135.
Title: Secretory RAB GTPase 3C modulates IL6-STAT3 pathway to promote colon cancer metastasis and is associated with poor prognosis.
Author: Chang, Yu-Chan|Su, Chia-Yi|Chen, Ming-Huang|Chen, Wei-Shone|Chen, Chi-Long|Hsiao, Michael
PMID: 28784136
Journal: Oncol Lett. 2017 Aug;14(2):1757-1765.
Title: R-spondin 2 promotes proliferation and migration via the Wnt/beta-catenin pathway in human hepatocellular carcinoma.
Author: Yin, Xinguang|Yi, Huixing|Wang, Linlin|Wu, Wanxin|Wu, Xiaojun|Yu, Linghua
PMID: 28789406
Journal: Oncol Lett. 2017 Aug;14(2):2177-2185.
Title: Effects of 17-allylamino-17-demethoxygeldanamycin on the induction of apoptosis and cell cycle arrest in HCT-116 cells.
Author: Zhao, Xuerong|Wang, Jianping|Xiao, Lijun|Xu, Qian|Zhao, Enhong|Zheng, Xin|Zheng, Huachuan|Zhao, Shuang|Ding, Shi
PMID: 28789442
Journal: Oncoimmunology. 2017 May 30;6(7):e1333215.
Title: Epigenetic regulation of the extrinsic oncosuppressor PTX3 gene in inflammation and cancer.
Author: Rubino, Marcello|Kunderfranco, Paolo|Basso, Gianluca|Greco, Carolina Magdalen|Pasqualini, Fabio|Serio, Simone|Roncalli, Massimo|Laghi, Luigi|Mantovani, Alberto|Papait, Roberto|Garlanda, Cecilia
PMID: 28811977
Journal: Mediators Inflamm. 2017;2017:5126048.
Title: The Role of Proinflammatory Pathways in the Pathogenesis of Colitis-Associated Colorectal Cancer.
Author: Luo, Chengxin|Zhang, Hu
PMID: 28852270
Journal: Elife. 2017 Sep 5;6.
Title: Stress responsive miR-31 is a major modulator of mouse intestinal stem cells during regeneration and tumorigenesis.
Author: Tian, Yuhua|Ma, Xianghui|Lv, Cong|Sheng, Xiaole|Li, Xiang|Zhao, Ran|Song, Yongli|Andl, Thomas|Plikus, Maksim V|Sun, Jinyue|Ren, Fazheng|Shuai, Jianwei|Lengner, Christopher J|Cui, Wei|Yu, Zhengquan
PMID: 28870287
Journal: Oncol Rep. 2017 Nov;38(5):2619-2628.
Title: alpha7 nicotinic acetylcholine receptor in tumor-associated macrophages inhibits colorectal cancer metastasis through the JAK2/STAT3 signaling pathway.
Author: Fei, Rushan|Zhang, Yuanwei|Wang, Saisai|Xiang, Tao|Chen, Wenbin
PMID: 28901507
Journal: Clin Cancer Res. 2017 Dec 1;23(23):7375-7387.
Title: The Immune-microenvironment Confers Chemoresistance of Colorectal Cancer through Macrophage-Derived IL6.
Author: Yin, Yuan|Yao, Surui|Hu, Yaling|Feng, Yuyang|Li, Min|Bian, Zehua|Zhang, Jiwei|Qin, Yan|Qi, Xiaowei|Zhou, Leyuan|Fei, Bojian|Zou, Jian|Hua, Dong|Huang, Zhaohui
PMID: 28928161
Journal: Cell Death Differ. 2017 Dec;24(12):2199-2209.
Title: miR-148a inhibits colitis and colitis-associated tumorigenesis in mice.
Author: Zhu, Yahui|Gu, Li|Li, Yajun|Lin, Xi|Shen, Hongxing|Cui, Kaisa|Chen, Li|Zhou, Feng|Zhao, Qiu|Zhang, Jinxiang|Zhong, Bo|Prochownik, Edward|Li, Youjun
PMID: 28960206
Journal: Oncogenesis. 2017 Oct 2;6(10):e384.
Title: Combination curcumin and (-)-epigallocatechin-3-gallate inhibits colorectal carcinoma microenvironment-induced angiogenesis by JAK/STAT3/IL-8 pathway.
Author: Jin, G|Yang, Y|Liu, K|Zhao, J|Chen, X|Liu, H|Bai, R|Li, X|Jiang, Y|Zhang, X|Lu, J|Dong, Z
PMID: 28967875
Journal: Sci Rep. 2017 Oct 2;7(1):12552.
Title: Ginsenosides Rb3 and Rd reduce polyps formation while reinstate the dysbiotic gut microbiota and the intestinal microenvironment in Apc(Min/+) mice.
Author: Huang, Guoxin|Khan, Imran|Li, Xiaoang|Chen, Lei|Leong, Waikit|Ho, Leung Tsun|Hsiao, W L Wendy
PMID: 28970547
Journal: Dig Dis Sci. 2017 Dec;62(12):3438-3446.
Title: IL-8 Is Involved in Estrogen-Related Receptor alpha-Regulated Proliferation and Migration of Colorectal Cancer Cells.
Author: Ding, Sijuan|Tang, Zhaohui|Jiang, Yongjun|Huang, Honglin|Luo, Pengfei|Qing, Bohua|Zhang, Siyuan|Tang, Ruoting
PMID: 28993941
Journal: Cell Biochem Funct. 2017 Oct;35(7):464-471.
Title: miR-214 activates TP53 but suppresses the expression of RELA, CTNNB1, and STAT3 in human cervical and colorectal cancer cells.
Author: Chandrasekaran, Karthik Subramanian|Sathyanarayanan, Anusha|Karunagaran, Devarajan
PMID: 29023799
Journal: Cancer Sci. 2017 Dec;108(12):2405-2412.
Title: Identification of zinc finger protein of the cerebellum 5 as a survival factor of prostate and colorectal cancer cells.
Author: Satow, Reiko|Inagaki, Shota|Kato, Chiaki|Shimozawa, Makoto|Fukami, Kiyoko
PMID: 29024195
Journal: Int J Oncol. 2017 Nov;51(5):1611-1620.
Title: Combination of FGFR4 inhibitor Blu9931 and 5-fluorouracil effects on the biological characteristics of colorectal cancer cells.
Author: Jiang, Dongbao|Li, Jingjing|Li, Jie|Wang, Min|Han, Chao|Wang, Xinru|Zhao, Chunlin|Ye, Yanwei
PMID: 29048661
Journal: Oncotarget. 2017 Aug 16;8(43):74649-74660.
Title: Fasting inhibits colorectal cancer growth by reducing M2 polarization of tumor-associated macrophages.
Author: Sun, Pengfei|Wang, Huihui|He, Zhiyong|Chen, Xiangyuan|Wu, Qichao|Chen, Wankun|Sun, Zhirong|Weng, Meilin|Zhu, Minmin|Ma, Duan|Miao, Changhong
PMID: 29088814
Journal: Oncotarget. 2017 Aug 12;8(45):78851-78869.
Title: S-adenosylmethionine and methylthioadenosine inhibit cancer metastasis by targeting microRNA 34a/b-methionine adenosyltransferase 2A/2B axis.
Author: Tomasi, Maria Lauda|Cossu, Carla|Spissu, Ylenia|Floris, Andrea|Ryoo, Minjung|Iglesias-Ara, Ainhoa|Wang, Qiang|Pandol, Stephen J|Bhowmick, Neil A|Seki, Ekihiro|Posadas, Edwin M|Lu, Shelly C
PMID: 29108270
Journal: Oncol Lett. 2017 Nov;14(5):6203-6209.
Title: JAB1-STAT3 activation loop is associated with recurrence following 5-fluorouracil-based adjuvant chemotherapy in human colorectal cancer.
Author: Kugimiya, Naruji|Nishimoto, Arata|Hosoyama, Tohru|Ueno, Koji|Takemoto, Yoshihiro|Harada, Eijiro|Enoki, Tadahiko|Hamano, Kimikazu
PMID: 29113268
Journal: Am J Cancer Res. 2017 Oct 1;7(10):2051-2069. eCollection 2017.
Title: MiR-216b functions as a tumor suppressor by targeting HMGB1-mediated JAK2/STAT3 signaling way in colorectal cancer.
Author: Chen, Xiaoxiang|Liu, Xiangxiang|He, Bangshun|Pan, Yuqin|Sun, Huiling|Xu, Tao|Hu, Xiuxiu|Wang, Shukui
PMID: 29119054
Journal: Am J Transl Res. 2017 Nov 15;9(11):4726-4737. eCollection 2017.
Title: IL-32theta: a recently identified anti-inflammatory variant of IL-32 and its preventive role in various disorders and tumor suppressor activity.
Author: Khawar, Muhammad Babar|Mukhtar, Maryam|Abbasi, Muddasir Hassan|Sheikh, Nadeem
PMID: 29218075
Journal: Sci Rep. 2017 Dec 14;7(1):17597.
Title: SHP2 associates with nuclear localization of STAT3: significance in progression and prognosis of colorectal cancer.
Author: Huang, Yan|Wang, Jie|Cao, Fuao|Jiang, Hailong|Li, An|Li, Jianzhong|Qiu, Lei|Shen, Hao|Chang, Wenjun|Zhou, Chuanxiang|Pan, Yamin|Lu, Yiming
PMID: 29242509
Journal: BMC Complement Altern Med. 2017 Dec 16;17(1):538.
Title: Inhibition of autophagy enhances synergistic effects of Salidroside and anti-tumor agents against colorectal cancer.
Author: Li, Hai|Chen, Chen
PMID: 29246220
Journal: Oncotarget. 2017 Oct 9;8(60):101760-101770.
Title: MiR-92a promotes stem cell-like properties by activating Wnt/beta-catenin signaling in colorectal cancer.
Author: Zhang, Guang-Jun|Li, Li-Fa|Yang, Guo-Dong|Xia, Shu-Sen|Wang, Rong|Leng, Zheng-Wei|Liu, Zuo-Liang|Tian, Hong-Peng|He, Yi|Meng, Chang-Yuan|Liu, Dai-Zhi|Hou, Song-Lin|Tang, Xue-Gui|Zhou, Tong
PMID: 29254202
Journal: Oncotarget. 2017 Nov 1;8(61):104330-104346.
Title: EphA2 signaling is impacted by carcinoembryonic antigen cell adhesion molecule 1-L expression in colorectal cancer liver metastasis in a cell context-dependent manner.
Author: Arabzadeh, Azadeh|McGregor, Kevin|Breton, Valerie|Van Der Kraak, Lauren|Akavia, Uri David|Greenwood, Celia M T|Beauchemin, Nicole
PMID: 29262644
Journal: Front Pharmacol. 2017 Dec 12;8:871.
Title: Curcumin-Free Turmeric Exhibits Activity against Human HCT-116 Colon Tumor Xenograft: Comparison with Curcumin and Whole Turmeric.
Author: Prasad, Sahdeo|Tyagi, Amit K|Siddik, Zahid H|Aggarwal, Bharat B
PMID: 29311914
Journal: Technol Cancer Res Treat. 2017 Dec;16(6):1209-1219.
Title: Phosphorylation of STAT3 Promotes Vasculogenic Mimicry by Inducing Epithelial-to-Mesenchymal Transition in Colorectal Cancer.
Author: Han, Cong|Sun, Baocun|Zhao, Xiulan|Zhang, Yanhui|Gu, Qiang|Liu, Fang|Zhao, Nan|Wu, Lili
PMID: 29333928
Journal: Oncol Lett. 2017 Dec;14(6):8197-8205.
Title: Hedyotis diffusa willd extract suppresses colorectal cancer growth through multiple cellular pathways.
Author: Feng, Jianyu|Jin, Yiyi|Peng, Jun|Wei, Lihui|Cai, Qiaoyan|Yan, Zhaokun|Lai, Zijun|Lin, Jiumao
PMID: 29344262
Journal: Integr Cancer Ther. 2018 Jun;17(2):271-281.
Title: Scorpion Venom Causes Upregulation of p53 and Downregulation of Bcl-xL and BID Protein Expression by Modulating Signaling Proteins Erk(1/2) and STAT3, and DNA Damage in Breast and Colorectal Cancer Cell Lines.
Author: Al-Asmari, Abdulrahman Khazim|Riyasdeen, Anvarbatcha|Islam, Mozaffarul
PMID: 28438053
Journal: Int J Cancer. 2018 Jan 1;142(1):121-132.
Title: G protein-coupled receptor GPR55 promotes colorectal cancer and has opposing effects to cannabinoid receptor 1.
Author: Hasenoehrl, Carina|Feuersinger, David|Sturm, Eva M|Barnthaler, Thomas|Heitzer, Ellen|Graf, Ricarda|Grill, Magdalena|Pichler, Martin|Beck, Stephan|Butcher, Lee|Thomas, Dominique|Ferreiros, Nerea|Schuligoi, Rufina|Schweiger, Caroline|Haybaeck, Johannes|Schi
PMID: 28875496
Journal: Am J Physiol Gastrointest Liver Physiol. 2018 Jan 1;314(1):G22-G31.
Title: Macrophage depletion using clodronate liposomes decreases tumorigenesis and alters gut microbiota in the AOM/DSS mouse model of colon cancer.
Author: Bader, Jackie E|Enos, Reilly T|Velazquez, Kandy T|Carson, Meredith S|Nagarkatti, Mitzi|Nagarkatti, Prakash S|Chatzistamou, Ioulia|Davis, J Mark|Carson, James A|Robinson, Cory M|Murphy, E Angela
PMID: 29025731
Journal: Asia Pac J Clin Oncol. 2018 Jun;14(3):134-140.
Title: Molecular targets for the therapy of cancer associated with metabolic syndrome (transcription and growth factors).
Author: Yunusova, Natalia V|Kondakova, Irina V|Kolomiets, Larisa A|Afanas'ev, Sergey G|Chernyshova, Alena L|Kudryavtsev, Igor V|Tsydenova, Anastasia A
PMID: 29115033
Journal: Gastroenterology. 2018 Mar;154(4):948-964.e8.
Title: Pyrin Inflammasome Regulates Tight Junction Integrity to Restrict Colitis and Tumorigenesis.
Author: Sharma, Deepika|Malik, Ankit|Guy, Clifford S|Karki, Rajendra|Vogel, Peter|Kanneganti, Thirumala-Devi
PMID: 29203393
Journal: Pharmacol Res. 2018 Jun;132:188-203.
Title: Novel 1,4-benzothazines obliterate COX-2 mediated JAK-2/STAT-3 signals with potential regulation of oxidative and metabolic stress during colorectal cancer.
Author: Rai, Amit|Kumar, Umesh|Raj, Vinit|Singh, Ashok K|Kumar, Pranesh|Keshari, Amit K|Kumar, Dinesh|Maity, Biswanath|De, Arnab|Samanta, Amalesh|Nath, Sneha|Prakash, Anand|Gosipatala, Sunil Babu|Chand, Gyan|Saha, Sudipta
PMID: 29229353
Journal: Clin Cancer Res. 2018 Mar 15;24(6):1473-1485.
Title: RING-Finger Protein 6 Amplification Activates JAK/STAT3 Pathway by Modifying SHP-1 Ubiquitylation and Associates with Poor Outcome in Colorectal Cancer.
Author: Liang, Qian|Ma, Dan|Zhu, Xiaoqiang|Wang, Zhenhua|Sun, Tian-Tian|Shen, Chaoqin|Yan, Tingting|Tian, Xianglong|Yu, TaChung|Guo, Fangfang|Tang, JiaYin|Lin, Yanwei|Chen, Huimin|Zhou, Chao|Ge, Zhizheng|Zhong, Ming|Chen, Jinxian|Liu, Qiang|Wang, Zheng|Fang, Jing
PMID: 29288235
Journal: Cell Death Dis. 2018 Jan 18;9(2):25.
Title: Human colorectal cancer-derived mesenchymal stem cells promote colorectal cancer progression through IL-6/JAK2/STAT3 signaling.
Author: Zhang, Xiaochao|Hu, Fayong|Li, Geng|Li, Guodong|Yang, Xi|Liu, Liang|Zhang, Rongsheng|Zhang, Bixiang|Feng, Yongdong
PMID: 29348540
Journal: Carcinogenesis. 2018 Mar 8;39(3):471-481.
Title: Chemoprevention of colorectal cancer by black raspberry anthocyanins involved the modulation of gut microbiota and SFRP2 demethylation.
Author: Chen, Lili|Jiang, Bowen|Zhong, Chunge|Guo, Jun|Zhang, Lihao|Mu, Teng|Zhang, Qiuhua|Bi, Xiuli
PMID: 29361151
Journal: Mol Cell Biochem. 2018 Sep;446(1-2):137-148.
Title: P16 promotes the growth and mobility potential of breast cancer both in vitro and in vivo: the key role of the activation of IL-6/JAK2/STAT3 signaling.
Author: Wang, Le|Zhan, Xiangwen|Shen, Xiaomeng|Li, Mingzhe|Yang, Jianming|Yu, Wenhua|Chen, Hao|Jin, Bo|Mao, Zebin
PMID: 29388151
Journal: Lancet Gastroenterol Hepatol. 2018 Apr;3(4):263-270.
Title: Napabucasin versus placebo in refractory advanced colorectal cancer: a randomised phase 3 trial.
Author: Jonker, Derek J|Nott, Louise|Yoshino, Takayuki|Gill, Sharlene|Shapiro, Jeremy|Ohtsu, Atsushi|Zalcberg, John|Vickers, Michael M|Wei, Alice C|Gao, Yuan|Tebbutt, Niall C|Markman, Ben|Price, Timothy|Esaki, Taito|Koski, Sheryl|Hitron, Matthew|Li, Wei|Li, Youzh
PMID: 29397354
Journal: Cell Host Microbe. 2018 Feb 14;23(2):203-214.e5.
Title: Bacteroides fragilis Toxin Coordinates a Pro-carcinogenic Inflammatory Cascade via Targeting of Colonic Epithelial Cells.
Author: Chung, Liam|Thiele Orberg, Erik|Geis, Abby L|Chan, June L|Fu, Kai|DeStefano Shields, Christina E|Dejea, Christine M|Fathi, Payam|Chen, Jie|Finard, Benjamin B|Tam, Ada J|McAllister, Florencia|Fan, Hongni|Wu, Xinqun|Ganguly, Sudipto|Lebid, Andriana|Metz, Pa
PMID: 29398651
Journal: Cell Physiol Biochem. 2018;45(2):808-818.
Title: Serine/Threonine Kinase 35, a Target Gene of STAT3, Regulates the Proliferation and Apoptosis of Osteosarcoma Cells.
Author: Wu, Zhong|Liu, Jie|Hu, Siyuan|Zhu, Yuchang|Li, Shaohua
PMID: 29414823
Journal: Oncol Lett. 2018 Feb;15(2):1949-1954.
Title: Dihydroartemisinin increases apoptosis of colon cancer cells through targeting Janus kinase 2/signal transducer and activator of transcription 3 signaling.
Author: Wang, Dongsheng|Zhong, Bei|Li, Yu|Liu, Xiaodong
PMID: 29434895
Journal: Anticancer Drugs. 2018 Jun;29(5):402-410.
Title: A novel small molecular STAT3 inhibitor, 5Br-6b, induces apoptosis and inhibits migration in colorectal cancer cells.
Author: Liu, Zhe|Wang, Huan|Guan, Lingnan|Chen, Siyi|Lai, Maode
PMID: 29438179
Journal: Cancer Biomark. 2018;21(4):849-858.
Title: LncRNA AB073614 induces epithelial- mesenchymal transition of colorectal cancer cells via regulating the JAK/STAT3 pathway.
Author: Xue, Jinfang|Liao, Liya|Yin, Fang|Kuang, Haoyu|Zhou, Xiaojun|Wang, Yanan
PMID: 29439310
Journal: Biomed Pharmacother. 2018 Apr;100:282-295.
Title: 6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid attenuates colon carcinogenesis via blockade of IL-6 mediated signals.
Author: Mishra, Priyanka|Raj, Vinit|Bhadauria, Archana S|Singh, Ashok K|Rai, Amit|Kumar, Pranesh|Keshari, Amit K|De, Arnab|Samanta, Amalesh|Kumar, Umesh|Kumar, Dinesh|Maity, Biswanath|Nath, Sneha|Prakash, Anand|Ansari, Kausar M|Saha, Sudipta
PMID: 29448205
Journal: Biochem Pharmacol. 2018 Apr;150:191-201.
Title: Natural small molecule bigelovin suppresses orthotopic colorectal tumor growth and inhibits colorectal cancer metastasis via IL6/STAT3 pathway.
Author: Li, Mingyue|Yue, Grace Gar-Lee|Song, Li-Hua|Huang, Mao-Bo|Lee, Julia Kin-Ming|Tsui, Stephen Kwok-Wing|Fung, Kwok-Pui|Tan, Ning-Hua|Lau, Clara Bik-San
PMID: 29454618
Journal: Oncotarget. 2017 Dec 8;9(5):5979-5992.
Title: Src is the primary target of aripiprazole, an atypical antipsychotic drug, in its anti-tumor action.
Author: Kim, Mi Seon|Yoo, Byong Chul|Yang, Woo Seok|Han, Sang Yun|Jeong, Deok|Song, Jun Min|Kim, Kyung Hee|Aravinthan, Adithan|Kim, Ji Hye|Kim, Jong-Hoon|Kim, Seung Cheol|Cho, Jae Youl
PMID: 29464048
Journal: J Exp Med. 2018 Apr 2;215(4):1205-1225.
Title: ADAM17 is required for EGF-R-induced intestinal tumors via IL-6 trans-signaling.
Author: Schmidt, Stefanie|Schumacher, Neele|Schwarz, Jeanette|Tangermann, Simone|Kenner, Lukas|Schlederer, Michaela|Sibilia, Maria|Linder, Markus|Altendorf-Hofmann, Annelore|Knosel, Thomas|Gruber, Elisabeth S|Oberhuber, Georg|Bolik, Julia|Rehman, Ateequr|Sinha, A
PMID: 29472497
Journal: Biomed Pharmacother. 2018 May;101:107-114.
Title: alpha-Hederin inhibits interleukin 6-induced epithelial-to-mesenchymal transition associated with disruption of JAK2/STAT3 signaling in colon cancer cells.
Author: Sun, Dongdong|Shen, Weixing|Zhang, Feng|Fan, Huisen|Xu, Changliang|Li, Liu|Tan, Jiani|Miao, Yunjie|Zhang, Haibin|Yang, Ye|Cheng, Haibo
PMID: 29477470
Journal: Am J Transl Res. 2018 Feb 15;10(2):465-473. eCollection 2018.
Title: Andrographolide presents therapeutic effect on ulcerative colitis through the inhibition of IL-23/IL-17 axis.
Author: Zhu, Qin|Zheng, Peifen|Chen, Xinyu|Zhou, Feng|He, Qiaona|Yang, Yuefeng
PMID: 29511440
Journal: Int J Oncol. 2018 Mar 5.
Title: Downregulation of SIRT6 by miR-34c-5p is associated with poor prognosis and promotes colon cancer proliferation through inhibiting apoptosis via the JAK2/STAT3 signaling pathway.
Author: Li, Ning|Mao, Dong|Cao, Yansha|Li, Hua|Ren, Fu|Li, Keyan
PMID: 29512698
Journal: Int J Oncol. 2018 Mar 7.
Title: Apigenin induces apoptosis by suppressing Bcl-xl and Mcl-1 simultaneously via signal transducer and activator of transcription 3 signaling in colon cancer.
Author: Maeda, Yuzo|Takahashi, Hiroki|Nakai, Nozomu|Yanagita, Takeshi|Ando, Nanako|Okubo, Tomotaka|Saito, Kenta|Shiga, Kazuyoshi|Hirokawa, Takahisa|Hara, Masayasu|Ishiguro, Hideyuki|Matsuo, Yoichi|Takiguchi, Shuji
PMID: 29512707
Journal: Clin Sci (Lond). 2018 May 23;132(9):985-1001.
Title: Cardiotrophin-1 attenuates experimental colitis in mice.
Author: Prieto-Vicente, Vanessa|Sanchez-Garrido, Ana I|Blanco-Gozalo, Victor|Arevalo, Miguel|Garcia-Sanchez, Enrique|Lopez-Montanes, Daniel|Quiros, Yaremi|Lopez-Hernandez, Francisco J|Rodriguez-Perez, Antonio|Lopez-Novoa, Jose M
PMID: 29572384
Journal: Cytokine. 2018 Mar 23. pii: S1043-4666(18)30112-1.
Title: Novel 1,3,4-thiadiazoles inhibit colorectal cancer via blockade of IL-6/COX-2 mediated JAK2/STAT3 signals as evidenced through data-based mathematical modeling.
Author: Raj, Vinit|Bhadauria, Archana S|Singh, Ashok K|Kumar, Umesh|Rai, Amit|Keshari, Amit K|Kumar, Pranesh|Kumar, Dinesh|Maity, Biswanath|Nath, Sneha|Prakash, Anand|Ansari, Kausar M|Jat, Jawahar L|Saha, Sudipta
PMID: 29580751
Journal: Onco Targets Ther. 2018 Mar 19;11:1543-1552.
Title: Novel long noncoding RNA GACAT3 promotes colorectal cancer cell proliferation, invasion, and migration through miR-149.
Author: Zhou, Weiwei|Wang, Lei|Miao, Yu|Xing, Rongge
PMID: 29593420
Journal: Mol Med Rep. 2018 Jun;17(6):7721-7729.
Title: Formononetin inhibits colon carcinoma cell growth and invasion by microRNA149mediated EphB3 downregulation and inhibition of PI3K/AKT and STAT3 signaling pathways.
Author: Wang, Ai-Lei|Li, Yong|Zhao, Qun|Fan, Li-Qiao
PMID: 29620230
Journal: Gene. 2018 Aug 5;666:18-26.
Title: Long non-coding RNA DILC suppresses cell proliferation and metastasis in colorectal cancer.
Author: Gu, Li-Qiang|Xing, Xiang-Lei|Cai, Hui|Si, An-Feng|Hu, Xian-Rong|Ma, Qian-Yun|Zheng, Meng-Lin|Wang, Ruo-Yu|Li, Heng-Yu|Zhang, Xi-Peng
PMID: 29621586
Journal: Int J Biochem Cell Biol. 2018 Jun;99:219-225.
Title: Long noncoding RNA BC200 regulates cell growth and invasion in colon cancer.
Author: Wu, Kaiming|Xu, Kaiwu|Liu, Kuanzhi|Huang, Jiehong|Chen, Jianhui|Zhang, Jian|Zhang, Ning
PMID: 29625226
Journal: Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):E4061-E4070.
Title: PARP-1 protects against colorectal tumor induction, but promotes inflammation-driven colorectal tumor progression.
Author: Dorsam, Bastian|Seiwert, Nina|Foersch, Sebastian|Stroh, Svenja|Nagel, Georg|Begaliew, Diana|Diehl, Erika|Kraus, Alexander|McKeague, Maureen|Minneker, Vera|Roukos, Vassilis|Reissig, Sonja|Waisman, Ari|Moehler, Markus|Stier, Anna|Mangerich, Aswin|Dantzer, F
PMID: 29632181
Journal: Oncotarget. 2018 Feb 26;9(21):15635-15649.
Title: Deletion of sphingosine kinase 1 inhibits liver tumorigenesis in diethylnitrosamine-treated mice.
Author: Chen, Jinbiao|Qi, Yanfei|Zhao, Yang|Kaczorowski, Dominik|Couttas, Timothy A|Coleman, Paul R|Don, Anthony S|Bertolino, Patrick|Gamble, Jennifer R|Vadas, Mathew A|Xia, Pu|McCaughan, Geoffrey W
PMID: 29643998
Journal: J Agric Food Chem. 2018 May 2;66(17):4384-4393.
Title: Tea Polysaccharides Inhibit Colitis-Associated Colorectal Cancer via Interleukin-6/STAT3 Pathway.
Author: Liu, Li Qiao|Nie, Shao Ping|Shen, Ming Yue|Hu, Jie Lun|Yu, Qiang|Gong, Deming|Xie, Ming Yong
PMID: 29656647
Journal: Nat Prod Res. 2018 Apr 23:1-4.
Title: Allicin inhibits mouse colorectal tumorigenesis through suppressing the activation of STAT3 signaling pathway.
Author: Li, Xiang|Ni, Jiahui|Tang, Yixin|Wang, Xu|Tang, Huanhuan|Li, Haidong|Zhang, Sulin|Shen, Xiaoyan
PMID: 29683343
Journal: Mol Carcinog. 2018 Sep;57(9):1156-1165.
Title: A supercritical CO2 extract of neem leaf (A. indica) and its bioactive liminoid, nimbolide, suppresses colon cancer in preclinical models by modulating pro-inflammatory pathways.
Author: Patel, Mandakini J|Tripathy, Shreya|Mukhopadhyay, Keya D|Wangjam, Tamna|Cabang, April B|Morris, Jay|Wargovich, Michael J
PMID: 29697164
Journal: Cytokine. 2018 Oct;110:116-125.
Title: The expression of IL10RA in colorectal cancer and its correlation with the proliferation index and the clinical stage of the disease.
Author: Zadka, Lukasz|Kulus, Michal J|Kurnol, Krzysztof|Piotrowska, Aleksandra|Glatzel-Plucinska, Natalia|Jurek, Tomasz|Czuba, Magdalena|Nowak, Aleksandra|Chabowski, Mariusz|Janczak, Dariusz|Dziegiel, Piotr
PMID: 29730384
Journal: Int J Cancer. 2018 Oct 15;143(8):1963-1977.
Title: Serum-derived carcinoembryonic antigen (CEA) activates fibroblasts to induce a local re-modeling of the extracellular matrix that favors the engraftment of CEA-expressing tumor cells.
Author: Abdul-Wahid, Aws|Cydzik, Marzena|Fischer, Nicholas W|Prodeus, Aaron|Shively, John E|Martel, Anne|Alminawi, Samira|Ghorab, Zeina|Berinstein, Neil L|Gariepy, Jean
PMID: 29756328
Journal: Carcinogenesis. 2018 Jul 3;39(7):889-899.
Title: M10, a novel derivative of Myricetin, prevents ulcerative colitis and colorectal tumor through attenuating robust endoplasmic reticulum stress.
Author: Wang, Feng|Song, Zhi-Yu|Qu, Xian-Jun|Li, Feng|Zhang, Liang|Li, Wen-Bao|Cui, Shu-Xiang
PMID: 29757351
Journal: FASEB J. 2018 Oct;32(10):5365-5377.
Title: Angiogenin and the MMP9-TIMP2 axis are up-regulated in proangiogenic, decidual NK-like cells from patients with colorectal cancer.
Author: Bruno, Antonino|Bassani, Barbara|D'Urso, Davide Giuseppe|Pitaku, Ilvana|Cassinotti, Elisa|Pelosi, Giuseppe|Boni, Luigi|Dominioni, Lorenzo|Noonan, Douglas M|Mortara, Lorenzo|Albini, Adriana
PMID: 29763380
Journal: Apoptosis. 2018 Jun;23(5-6):356-374.
Title: Down-regulating IL-6/GP130 targets improved the anti-tumor effects of 5-fluorouracil in colon cancer.
Author: Li, Sanhong|Tian, Jilai|Zhang, Hongming|Zhou, Shoubing|Wang, Xiyong|Zhang, Lei|Yang, Jiapeng|Zhang, Zhigang|Ji, Zhenling
PMID: 29777330
Journal: Mol Med Rep. 2018 Jul;18(1):1113-1119.
Title: Pien Tze Huang ameliorates DSSinduced colonic inflammation in a mouse colitis model through inhibition of the IL6/STAT3 pathway.
Author: Li, Li|Shen, Aling|Chu, Jianfeng|Sferra, Thomas J|Sankararaman, Senthilkumar|Ke, Xiao|Chen, Youqin|Peng, Jun
PMID: 29845215
Journal: Med Sci Monit. 2018 Jun 3;24:3710-3719.
Title: Quinalizarin Induces Apoptosis through Reactive Oxygen Species (ROS)-Mediated Mitogen-Activated Protein Kinase (MAPK) and Signal Transducer and Activator of Transcription 3 (STAT3) Signaling Pathways in Colorectal Cancer Cells.
Author: Meng, Ling-Qi|Wang, Yue|Luo, Ying-Hua|Piao, Xian-Ji|Liu, Chang|Wang, Yue|Zhang, Yi|Wang, Jia-Ru|Wang, Hao|Xu, Wan-Ting|Liu, Yang|Wu, Yi-Qin|Sun, Hu-Nan|Han, Ying-Hao|Jin, Mei-Hua|Shen, Gui-Nan|Fang, Nan-Zhu|Jin, Cheng-Hao
PMID: 29860266
Journal: Gene. 2018 Sep 25;672:64-71.
Title: The detection and significance of cystic fibrosis transmembrane conductance regulator gene promoter mutations in Chinese patients with congenital bilateral absence of the vas deferens.
Author: Bai, Song|Du, Qiang|Liu, Xiaoliang|Tong, Yuxin|Wu, Bin
PMID: 29864494
Journal: Lab Invest. 2018 Aug;98(8):989-998.
Title: RAC1-GTP promotes epithelial-mesenchymal transition and invasion of colorectal cancer by activation of STAT3.
Author: Zhou, Kai|Rao, Jun|Zhou, Zhi-Hua|Yao, Xiao-Hong|Wu, Feng|Yang, Jing|Yang, Lang|Zhang, Xia|Cui, You-Hong|Bian, Xiu-Wu|Shi, Yu|Ping, Yi-Fang
PMID: 29884911
Journal: Onco Targets Ther. 2018 Jun 5;11:3313-3322.
Title: Novel quinazoline-based sulfonamide derivative (3D) induces apoptosis in colorectal cancer by inhibiting JAK2-STAT3 pathway.
Author: Al-Obeed, Omar|Vaali-Mohammed, Mansoor-Ali|Eldehna, Wagdy M|Al-Khayal, Khayal|Mahmood, Amer|Abdel-Aziz, Hatem A|Zubaidi, Ahmed|Alafeefy, Ahmed|Abdulla, Maha|Ahmad, Rehan
PMID: 29892198
Journal: Theranostics. 2018 Apr 30;8(11):3022-3037.
Title: PIAS3-mediated feedback loops promote chronic colitis-associated malignant transformation.
Author: Ma, Junting|Yang, Yaping|Fu, Yong|Guo, Feilong|Zhang, Xiaoyi|Xiao, Shuke|Zhu, Weiming|Huang, Zhen|Zhang, Junfeng|Chen, Jiangning
PMID: 29896300
Journal: Mol Oncol. 2018 Aug;12(8):1398-1409.
Title: Macrophage migration inhibitory factor promotes resistance to MEK blockade in KRAS mutant colorectal cancer cells.
Author: Cheon, Seul-Ki|Kim, Hwang-Phill|Park, Ye-Lim|Jang, Jee-Eun|Lim, Yoojoo|Song, Sang-Hyun|Han, Sae-Won|Kim, Tae-You
PMID: 29896883
Journal: Cell Death Dis. 2018 Jun 13;9(6):702.
Title: Magnolin promotes autophagy and cell cycle arrest via blocking LIF/Stat3/Mcl-1 axis in human colorectal cancers.
Author: Yu, Haiyang|Yin, Shuangshuang|Zhou, Shiyue|Shao, Yingying|Sun, Jiachen|Pang, Xu|Han, Lifeng|Zhang, Yi|Gao, Xiumei|Jin, Chengyun|Qiu, Yuling|Wang, Tao
PMID: 29899555
Journal: Cell. 2018 Jun 28;174(1):88-101.e16.
Title: Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis.
Author: Ziegler, Paul K|Bollrath, Julia|Pallangyo, Charles K|Matsutani, Takaji|Canli, Ozge|De Oliveira, Tiago|Diamanti, Michaela A|Muller, Nina|Gamrekelashvili, Jaba|Putoczki, Tracy|Horst, David|Mankan, Arun K|Oner, Meryem G|Muller, Susanna|Muller-Hocker, Josef|K
PMID: 29909986
Journal: Int J Mol Sci. 2018 Jun 16;19(6). pii: ijms19061787.
Title: STAT3 Interactors as Potential Therapeutic Targets for Cancer Treatment.
Author: Laudisi, Federica|Cherubini, Fabio|Monteleone, Giovanni|Stolfi, Carmine
PMID: 29914167
Journal: Clin Cancer Res. 2018 Oct 1;24(19):4808-4819.
Title: LncRNA-FEZF1-AS1 Promotes Tumor Proliferation and Metastasis in Colorectal Cancer by Regulating PKM2 Signaling.
Author: Bian, Zehua|Zhang, Jiwei|Li, Min|Feng, Yuyang|Wang, Xue|Zhang, Jia|Yao, Surui|Jin, Guoying|Du, Jun|Han, Weifeng|Yin, Yuan|Huang, Shenglin|Fei, Bojian|Zou, Jian|Huang, Zhaohui
PMID: 29914894
Journal: J Cell Physiol. 2018 Nov;233(11):8526-8537.
Title: EGFL7: Master regulator of cancer pathogenesis, angiogenesis and an emerging mediator of bone homeostasis.
Author: Hong, Guoju|Kuek, Vincent|Shi, Jiaxi|Zhou, Lin|Han, Xiaorui|He, Wei|Tickner, Jennifer|Qiu, Heng|Wei, Qiushi|Xu, Jiake
PMID: 29923200
Journal: Rejuvenation Res. 2018 Sep 4.
Title: STAT3/c-Myc Axis-Mediated Metabolism Alternations of Inflammation-Related Glycolysis Involve with Colorectal Carcinogenesis.
Author: Zhang, Sha|Li, Jie|Xie, Pei|Zang, Ting|Shen, Haibin|Cao, Guochun|Zhu, Ying|Yue, Zhenggang|Li, Zhe
PMID: 29932015
Journal: Int Immunopharmacol. 2018 Aug;61:346-354.
Title: Over-expressed miRNA-200b ameliorates ulcerative colitis-related colorectal cancer in mice through orchestrating epithelial-mesenchymal transition and inflammatory responses by channel of AKT2.
Author: Deng, Shuangjiao|Wang, Hongfei|Fan, Heng|Zhang, Lijuan|Hu, Jianli|Tang, Qing|Shou, Zhexing|Liu, Xingxing|Zuo, Dongmei|Yang, Jia|Xu, Meng|Chen, Qianyun|Dong, Yalan|Nan, Zhen|Wu, Hui|Liu, Yujin
PMID: 29933193
Journal: Onco Targets Ther. 2018 Jun 15;11:3475-3484.
Title: STAT3 induces colorectal carcinoma progression through a novel miR-572-MOAP-1 pathway.
Author: Wang, Nan|He, Xianli|Zhou, Ru|Jia, Guozhan|Qiao, Qing
PMID: 29942139
Journal: Cell. 2018 Jun 28;174(1):14-16.
Title: The Walrus and the Carpenter: Complex Regulation of Tumor Immunity in Colorectal Cancer.
Author: Dewson, Grant|Silke, John
PMID: 29958104
Journal: Carcinogenesis. 2018 Jul 3;39(7):911-920.
Title: Nitric oxide-donating aspirin (NO-Aspirin) suppresses lung tumorigenesis in vitro and in vivo and these effects are associated with modulation of the EGFR signaling pathway.
Author: Song, Jung Min|Upadhyaya, Pramod|Kassie, Fekadu
PMID: 29982425
Journal: Oncol Rep. 2018 Aug;40(2):887-894.
Title: Silencing of Girdin suppresses the malignant behavior of colorectal carcinoma cells.
Author: Lu, Jia|Zhang, Lin|Zhou, Hongyan|Du, Zhenwu|Zhang, Guizhen
PMID: 29989653
Journal: Cancer Immunol Res. 2018 Sep;6(9):1082-1092.
Title: RORgammat-Expressing Tregs Drive the Growth of Colitis-Associated Colorectal Cancer by Controlling IL6 in Dendritic Cells.
Author: Rizzo, Angelamaria|Di Giovangiulio, Martina|Stolfi, Carmine|Franze, Eleonora|Fehling, Hans-Joerg|Carsetti, Rita|Giorda, Ezio|Colantoni, Alfredo|Ortenzi, Angela|Rugge, Massimo|Mescoli, Claudia|Monteleone, Giovanni|Fantini, Massimo C
PMID: 29991500
Journal: Chem Biol Interact. 2018 Sep 25;293:94-99.
Title: Interaction of STAT3 and RelB modulates MMP-1 in colon cancer.
Author: Jiang, Xue-Feng|Ding, Lei|Tian, Yuan|Han, Ning|Li, Zhi-Qi
PMID: 30040915
Journal: Sci Rep. 2018 Jul 26;8(1):11285.
Title: Annexin A2 overexpression associates with colorectal cancer invasiveness and TGF-ss induced epithelial mesenchymal transition via Src/ANXA2/STAT3.
Author: Rocha, Murilo R|Barcellos-de-Souza, Pedro|Sousa-Squiavinato, Annie Cristhine M|Fernandes, Priscila V|de Oliveira, Ivanir M|Boroni, Mariana|Morgado-Diaz, Jose A
PMID: 30050103
Journal: J Cell Mol Med. 2018 Oct;22(10):5040-5049.
Title: A positive feedback loop between miR-181b and STAT3 that affects Warburg effect in colon cancer via regulating PIAS3 expression.
Author: Pan, Xiaolin|Feng, Jin|Zhu, Zhenhua|Yao, Linhua|Ma, Shijie|Hao, Bo|Zhang, Guoxin
PMID: 30054984
Journal: Anticancer Res. 2018 Aug;38(8):4485-4491.
Title: Cannabinoid Receptor-1 Up-regulation in Azoxymethane (AOM)-treated Mice After Dietary Treatment with Quercetin.
Author: Tutino, Valeria|DE Nunzio, Valentina|Tafaro, Angela|Bianco, Giusy|Gigante, Isabella|Scavo, Maria Principia|D'Alessandro, Rosalba|Refolo, Maria Grazia|Messa, Caterina|Caruso, Maria Gabriella|Notarnicola, Maria
PMID: 30061214
Journal: Gastroenterology. 2018 Jul 28. pii: S0016-5085(18)34816-9.
Title: Activated ATF6 Induces Intestinal Dysbiosis and Innate Immune Response to Promote Colorectal Tumorigenesis.
Author: Coleman, O I|Lobner, E M|Bierwirth, S|Sorbie, A|Waldschmitt, N|Rath, E|Berger, E|Lagkouvardos, I|Clavel, T|McCoy, K D|Weber, A|Heikenwalder, M|Janssen, K P|Haller, D
PMID: 30063920
Journal: J Biomed Sci. 2018 Aug 2;25(1):60.
Title: STAT3 exacerbates survival of cancer stem-like tumorspheres in EGFR-positive colorectal cancers: RNAseq analysis and therapeutic screening.
Author: Cheng, Chun-Chia|Liao, Po-Nien|Ho, Ai-Sheng|Lim, Ken-Hong|Chang, Jungshan|Su, Ying-Wen|Chen, Caleb Gon-Shen|Chiang, Ya-Wen|Yang, Bi-Ling|Lin, Huan-Chau|Chang, Yu-Cheng|Chang, Chun-Chao|Chang, Yi-Fang
PMID: 30068339
Journal: Phytomedicine. 2018 Jul 15;46:131-141.
Title: Turmeric extract, with absorbable curcumin, has potent anti-metastatic effect in vitro and in vivo.
Author: Li, Mingyue|Yue, Grace Gar-Lee|Tsui, Stephen Kwok-Wing|Fung, Kwok-Pui|Lau, Clara Bik-San
PMID: 30097113
Journal: Gastroenterology. 2018 Aug 9. pii: S0016-5085(18)34868-6.
Title: Combined Inactivation of TP53 and MIR34A Promotes Colorectal Cancer Development and Progression in Mice via Increasing Levels of IL6R and PAI1.
Author: Oner, Meryem Gulfem|Rokavec, Matjaz|Kaller, Markus|Bouznad, Nassim|Horst, David|Kirchner, Thomas|Hermeking, Heiko
PMID: 30099074
Journal: Cancer Cell. 2018 Aug 13;34(2):298-314.e7.
Title: Therapeutic Ablation of Gain-of-Function Mutant p53 in Colorectal Cancer Inhibits Stat3-Mediated Tumor Growth and Invasion.
Author: Schulz-Heddergott, Ramona|Stark, Nadine|Edmunds, Shelley J|Li, Jinyu|Conradi, Lena-Christin|Bohnenberger, Hanibal|Ceteci, Fatih|Greten, Florian R|Dobbelstein, Matthias|Moll, Ute M
PMID: 30107178
Journal: Cell Death Discov. 2018 Aug 13;5:25.
Title: Two novel SHP-1 agonists, SC-43 and SC-78, are more potent than regorafenib in suppressing the in vitro stemness of human colorectal cancer cells.
Author: Chung, Shin-Yi|Chen, Yen-Hsi|Lin, Pei-Rong|Chao, Ta-Chung|Su, Jung-Chen|Shiau, Chung-Wai|Su, Yeu
PMID: 30109144
Journal: Cancer Immunol Immunother. 2018 Oct;67(10):1635-1646.
Title: Fusobacterium nucleatum promotes M2 polarization of macrophages in the microenvironment of colorectal tumours via a TLR4-dependent mechanism.
Author: Chen, Ting|Li, Qing|Wu, Jiao|Wu, Yaxin|Peng, Wei|Li, Huan|Wang, Jianmei|Tang, Xiaowei|Peng, Yan|Fu, Xiangsheng
PMID: 30121899
Journal: Sci Rep. 2018 Aug 20;8(1):12424.
Title: The tyrosine phosphorylated pro-survival form of Fas intensifies the EGF-induced signal in colorectal cancer cells through the nuclear EGFR/STAT3-mediated pathway.
Author: Ta, Ngoc Ly|Chakrabandhu, Krittalak|Huault, Sebastien|Hueber, Anne-Odile
PMID: 30127519
Journal: Front Pharmacol. 2018 Aug 8;9:881.
Title: Lycorine Displays Potent Antitumor Efficacy in Colon Carcinoma by Targeting STAT3.
Author: Wu, Song|Qiu, Yuling|Shao, Yingying|Yin, Shuangshuang|Wang, Rui|Pang, Xu|Ma, Junhong|Zhang, Chunze|Wu, Bo|Koo, Sangho|Han, Lifeng|Zhang, Yi|Gao, Xiumei|Wang, Tao|Yu, Haiyang
PMID: 30135654
Journal: Acta Pharmacol Sin. 2018 Aug 31. pii: 10.1038/s41401-018-0157-9.
Title: Acetyl-11-keto-beta-boswellic acid suppresses docetaxel-resistant prostate cancer cells in vitro and in vivo by blocking Akt and Stat3 signaling, thus suppressing chemoresistant stem cell-like properties.
Author: Liu, Yong-Qing|Wang, Shi-Kang|Xu, Qing-Qing|Yuan, Hui-Qing|Guo, Yan-Xia|Wang, Qian|Kong, Feng|Lin, Zhao-Min|Sun, De-Qing|Wang, Rong-Mei|Lou, Hong-Xiang
PMID: 30171201
Journal: Mol Cell Biol. 2018 Sep 4. pii: MCB.00386-18.
Title: Myc-Associated Zinc Finger Protein Regulates the Pro-Inflammatory Response in Colitis and Colon Cancer via STAT3 Signaling.
Author: Triner, Daniel|Castillo, Cristina|Hakim, Joe B|Xue, Xiang|Greenson, Joel K|Nunez, Gabriel|Chen, Grace Y|Colacino, Justin A|Shah, Yatrik M
PMID: 30181395
Journal: Transl Oncol. 2018 Dec;11(6):1379-1389.
Title: Sorcin a Potential Molecular Target for Cancer Therapy.
Author: Shabnam, Bano|Padmavathi, Ganesan|Banik, Kishore|Girisa, Sosmitha|Monisha, Javadi|Sethi, Gautam|Fan, Lu|Wang, Lingzhi|Mao, Xinliang|Kunnumakkara, Ajaikumar B
PMID: 30216763
Journal: Biomed Pharmacother. 2018 Sep 19;108:618-624.
Title: PMA treated THP-1-derived-IL-6 promotes EMT of SW48 through STAT3/ERK-dependent activation of Wnt/beta-catenin signaling pathway.
Author: Gao, Sikang|Hu, Junwu|Wu, Xiongwen|Liang, Zhihui
PMID: 30243096
Journal: Oncotarget. 2018 Aug 31;9(68):32943-32957.
Title: Combination of resveratrol and 5-flurouracil enhanced anti-telomerase activity and apoptosis by inhibiting STAT3 and Akt signaling pathways in human colorectal cancer cells.
Author: Chung, Seyung S|Dutta, Pranabananda|Austin, David|Wang, Piwen|Awad, Adam|Vadgama, Jaydutt V
PMID: 30250641
Journal: J Surg Res. 2018 Nov;231:323-330.
Title: Upregulation of phosphorylated sphingosine kinase 1 expression in colitis-associated cancer.
Author: Yuza, Kizuki|Nagahashi, Masayuki|Shimada, Yoshifumi|Nakano, Mae|Tajima, Yosuke|Kameyama, Hitoshi|Nakajima, Masato|Takabe, Kazuaki|Wakai, Toshifumi
PMID: 30278948
Journal: IUBMB Life. 2018 Nov;70(11):1093-1100.
Title: Long noncoding RNA FAL1 promotes proliferation and inhibits apoptosis of human colon cancer cells.
Author: Wu, Kaiming|Zhang, Ning|Ma, Jun|Huang, Jiehong|Chen, Jianhui|Wang, Liang|Zhang, Jian
PMID: 30290064
Journal: Ecotoxicol Environ Saf. 2018 Oct 9;167:107-113.
Title: Microcystin-LR promotes migration via the cooperation between microRNA-221/PTEN and STAT3 signal pathway in colon cancer cell line DLD-1.
Author: Ren, Yan|Yang, Mengli|Ma, Rong|Gong, Ying|Zou, Yuntao|Wang, Ting|Wu, Jianzhong
PMID: 30312888
Journal: J Cell Biochem. 2018 Oct 15.
Title: Signal transducer and activator of transcription 3 inhibition enhances vemurafenib sensitivity in colon cancers harboring the BRAF(V600E) mutation.
Author: Wang, Kai|Li, Yanrong|Song, Na|Che, Xiaofang|Hou, Kezuo|Xu, Ling|Bai, Ming|Wang, Qiwei|Wang, Yuanhe|Zhou, Yang|Cao, Meihui|Liu, Yunpeng|Zhang, Jingdong
PMID: 30320916
Journal: Int J Mol Sci. 2018 Oct 12;19(10). pii: ijms19103127.
Title: Emodin Sensitizes Hepatocellular Carcinoma Cells to the Anti-Cancer Effect of Sorafenib through Suppression of Cholesterol Metabolism.
Author: Kim, Young-Seon|Lee, Yoon-Mi|Oh, Taek-In|Shin, Dong Hoon|Kim, Geon-Hee|Kan, Sang-Yeon|Kang, Hyeji|Kim, Ji Hyung|Kim, Byeong Mo|Yim, Woo Jong|Lim, Ji-Hong
PMID: 30321984
Journal: Oncotarget. 2018 Sep 18;9(73):33865.
Title: Correction: The ratio of STAT1 to STAT3 expression is a determinant of colorectal cancer growth.
Author: Nivarthi, Harini|Gordziel, Claire|Themanns, Madeleine|Kramer, Nina|Eberl, Markus|Rabe, Bjorn|Schlederer, Michaela|Rose-John, Stefan|Knosel, Thomas|Kenner, Lukas|Freund, Patricia|Aberger, Fritz|Han, Xiaonan|Kralovics, Robert|Dolznig, Helmut|Jennek, Susanne
PMID: 30333916
Journal: Oncol Lett. 2018 Nov;16(5):5575-5582.
Title: Effects and mechanism of STAT3 silencing on the growth and apoptosis of colorectal cancer cells.
Author: Li, Jing|Liu, You-Yu|Yang, Xue-Feng|Shen, Dao-Fu|Sun, Hong-Zhi|Huang, Ke-Qiang|Zheng, Hua-Chuan
PMID: 30344711
Journal: Prostate. 2018 Oct 21.
Title: A role for paracrine interleukin-6 signaling in the tumor microenvironment in prostate tumor growth.
Author: Yu, Shu-Han|Maynard, Janielle P|Vaghasia, Ajay M|De Marzo, Angelo M|Drake, Charles G|Sfanos, Karen S
PMID: 30345534
Journal: Oncogene. 2018 Oct 22. pii: 10.1038/s41388-018-0547-y.
Title: Targeting colon cancer with the novel STAT3 inhibitor bruceantinol.
Author: Wei, Ning|Li, Jun|Fang, Cheng|Chang, Jin|Xirou, Vasiliki|Syrigos, Nick K|Marks, Benjamin J|Chu, Edward|Schmitz, John C
PMID: 30348989
Journal: Oncoimmunology. 2018 Aug 24;7(11):e1498437.
Title: Embelin impairs the accumulation and activation of MDSCs in colitis-associated tumorigenesis.
Author: Wu, Ting|Wang, Chaohui|Wang, Weihong|Hui, Yuhang|Zhang, Rongxin|Qiao, Liang|Dai, Yun
PMID: 30377563
Journal: Int J Mol Med. 2018 Nov 1.
Title: Resveratrol suppresses colon cancer growth by targeting the AKT/STAT3 signaling pathway.
Author: Li, Dan|Wang, Gangcheng|Jin, Guoguo|Yao, Ke|Zhao, Zhenjiang|Bie, Liangyu|Guo, Yongjun|Li, Ning|Deng, Wenying|Chen, Xiaobin|Chen, Beibei|Liu, Yuanyuan|Luo, Suxia|Guo, Zhiping
PMID: 30387805