Primary Site >> Colorectal Cancer
Gene >> STAT3
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Ref: IL-13 induces phosphorylation and activation of JAK2 Janus kinase in human colon carcinoma cell lines: similarities between IL-4 and IL-13 signaling. PMID: 8609418 |
Ref: Biochemical and cellular effects of c-Src kinase-selective pyrido[2, 3-d]pyrimidine tyrosine kinase inhibitors. PMID: 10974196 |
Ref: Gamma interferon down-regulates Fer and induces its association with inactive Stat3 in colon carcinoma cells. PMID: 12118379 |
Ref: Src family kinase activity is required for signal tranducer and activator of transcription 3 and focal adhesion kinase phosphorylation and vascular endothelial growth factor signaling in vivo and for anchorage-dependent and -independent growth of human tu PMID: 12748308 Ref: [Stat3 signal transduction pathway orchestrates G1 to S cell cycle transition in colon cancer cells]. PMID: 12920809 Ref: [Relationship of Stat3 and its target gene products with malignancy in human colorectal carcinoma]. PMID: 14613639 |
Ref: Recruitment of STAT3 for production of IL-10 by colon carcinoma cells induced by macrophage-derived IL-6. PMID: 15034082 Ref: Disruption of STAT3 signaling leads to tumor cell invasion through alterations of homotypic cell-cell adhesion complexes. PMID: 15077188 Ref: Constitutive activation of Stat3 signaling pathway in human colorectal carcinoma. PMID: 15162527 Ref: Immunohistochemical expression of HGF, c-MET and transcription factor STAT3 in colorectal tumors. PMID: 15590419 Ref: Elimination of hepatic metastases of colon cancer cells via p53-independent cross-talk between irinotecan and Apo2 ligand/TRAIL. PMID: 15604280 Ref: Inhibition of constitutive signal transducer and activator of transcription 3 activation by novel platinum complexes with potent antitumor activity. PMID: 15634646 Ref: Atiprimod is an inhibitor of cancer cell proliferation and angiogenesis. PMID: 15844657 |
Ref: The broad-range cyclin-dependent kinase inhibitor UCN-01 induces apoptosis in colon carcinoma cells through transcriptional suppression of the Bcl-x(L) protein. PMID: 15467762 Ref: Augmentation of differentiation and gap junction function by kaempferol in partially differentiated colon cancer cells. PMID: 15618237 Ref: Implication of STAT3 signaling in human colonic cancer cells during intestinal trefoil factor 3 (TFF3) -- and vascular endothelial growth factor-mediated cellular invasion and tumor growth. PMID: 15665295 Ref: Growth hormone inhibits signal transducer and activator of transcription 3 activation and reduces disease activity in murine colitis. PMID: 16012947 Ref: Persistent STAT3 activation in colon cancer is associated with enhanced cell proliferation and tumor growth. PMID: 16036105 Ref: Expression of p-STAT3 in human colorectal adenocarcinoma and adenoma; correlation with clinicopathological factors. PMID: 16049285 Ref: Involvement of IL-6 in the pathogenesis of inflammatory bowel disease and colon cancer. PMID: 16129903 Ref: Constitutive activation of JAK3/STAT3 in colon carcinoma tumors and cell lines: inhibition of JAK3/STAT3 signaling induces apoptosis and cell cycle arrest of colon carcinoma cells. PMID: 16192633 Ref: [Correlation between Stat3 signal transduction pathway and expression of cyclooxygenase-2 in colorectal cancer cells]. PMID: 16324362 |
Ref: Functional expression of the interleukin-11 receptor alpha-chain in normal colonic epithelium and colon cancer. PMID: 16292518 Ref: Glycine-extended gastrin inhibits apoptosis in colon cancer cells via separate activation of Akt and JNK pathways. PMID: 16442704 Ref: A growth-suppressive function for the c-fes protein-tyrosine kinase in colorectal cancer. PMID: 16455651 Ref: Signal transducers and activators of transcription 3 activation is involved in nuclear accumulation of beta-catenin in colorectal cancer. PMID: 16540637 Ref: Interleukin-6 production induced by leptin treatment promotes cell proliferation in an Apc (Min/+) colon epithelial cell line. PMID: 16597643 Ref: Activation of STAT3 is a marker of poor prognosis in human colorectal cancer. PMID: 16685378 Ref: Functional expression of a biologically active fragment of soluble gp130 as an ELP-fusion protein in transgenic plants: purification via inverse transition cycling. PMID: 16716147 Ref: IFNgamma-dependent, spontaneous development of colorectal carcinomas in SOCS1-deficient mice. PMID: 16717119 Ref: Antisense to cyclin D1 inhibits vascular endothelial growth factor-stimulated growth of vascular endothelial cells: implication of tumor vascularization. PMID: 16899623 |
Ref: The anti-apoptotic and growth stimulatory actions of leptin in human colon cancer cells involves activation of JNK mitogen activated protein kinase, JAK2 and PI3 kinase/Akt. PMID: 16912864 Ref: PRL3 promotes cell invasion and proliferation by down-regulation of Csk leading to Src activation. PMID: 17192274 Ref: STAT3 mRNA and protein expression in colorectal cancer: effects on STAT3-inducible targets linked to cell survival and proliferation. PMID: 17264243 Ref: Co-expression of EGF receptor, TGFalpha and S6 kinase is significantly associated with colorectal carcinomas with distant metastases at diagnosis. PMID: 17265080 Ref: Suppressor of cytokine signaling 3 (SOCS3) limits damage-induced crypt hyper-proliferation and inflammation-associated tumorigenesis in the colon. PMID: 17297444 Ref: Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T. PMID: 17360477 Ref: The interleukin-22/STAT3 pathway potentiates expression of inducible nitric-oxide synthase in human colon carcinoma cells. PMID: 17438334 Ref: Interleukin 31 mediates MAP kinase and STAT1/3 activation in intestinal epithelial cells and its expression is upregulated in inflammatory bowel disease. PMID: 17449633 Ref: Signal transducer and activator of transcription 3 activation promotes invasive growth of colon carcinomas through matrix metalloproteinase induction. PMID: 17460772 Ref: Eps8 facilitates cellular growth and motility of colon cancer cells by increasing the expression and activity of focal adhesion kinase. PMID: 17496330 Ref: [Correlations of GRIM-19 and its target gene product STAT3 to malignancy of human colorectal carcinoma]. PMID: 17626740 |
Ref: Stat3 up-regulates expression of nicotinamide N-methyltransferase in human cancer cells. PMID: 17922140 Ref: The role of signal transducers and activators of transcription in colon cancer. PMID: 17981761 Ref: Inhibition of signal transducer and activator of transcription 3 expression by RNA interference suppresses invasion through inducing anoikis in human colon cancer cells. PMID: 18200666 Ref: The EGFR-STAT3 oncogenic pathway up-regulates the Eme1 endonuclease to reduce DNA damage after topoisomerase I inhibition. PMID: 18245483 Ref: Inhibition of JAK1, 2/STAT3 signaling induces apoptosis, cell cycle arrest, and reduces tumor cell invasion in colorectal cancer cells. PMID: 18320073 Ref: Identification of a functional EGF-R/p60c-src/STAT3 pathway in colorectal carcinoma: analysis of its long-term prognostic value. PMID: 18503159 Ref: Activated kRas protects colon cancer cells from cucurbitacin-induced apoptosis: the role of p53 and p21. PMID: 18561895 Ref: Single cell cytometry of protein function in RNAi treated cells and in native populations. PMID: 18673568 Ref: Guggulsterone inhibits angiogenesis by blocking STAT3 and VEGF expression in colon cancer cells. PMID: 19020709 |
Ref: Epidermal growth factor receptor status and persistent activation of Akt and p44/42 MAPK pathways correlate with the effect of cetuximab in head and neck and colon cancer cell lines. PMID: 18813952 Ref: Melatonin suppresses AOM/DSS-induced large bowel oncogenesis in rats. PMID: 19028472 Ref: A germline mutation (A339V) in thyroid transcription factor-1 (TITF-1/NKX2.1) in patients with multinodular goiter and papillary thyroid carcinoma. PMID: 19176457 Ref: Inflammation and cancer: IL-6 and STAT3 complete the link. PMID: 19185839 Ref: Macrophage-derived interleukin-6 up-regulates MUC1, but down-regulates MUC2 expression in the human colon cancer HT-29 cell line. PMID: 19201396 Ref: Interleukin-6 (IL-6) released by macrophages induces IL-6 secretion in the human colon cancer HT-29 cell line. PMID: 19272324 Ref: Expression of gastrin precursors by CD133-positive colorectal cancer cells is crucial for tumour growth. PMID: 19321126 Ref: Association of early phase of colorectal carcinogenesis with STAT3 activation and its relevance in apoptosis regulation. PMID: 19341726 Ref: Role of eotaxin-1 signaling in ovarian cancer. PMID: 19351767 Ref: Efficient killing of SW480 colon carcinoma cells by a signal transducer and activator of transcription (STAT) 3 hairpin decoy oligodeoxynucleotide--interference with interferon-gamma-STAT1-mediated killing. PMID: 19476491 Ref: alpha2,6-hyposialylation of c-Met abolishes cell motility of ST6Gal-I-knockdown HCT116 cells. PMID: 19483716 Ref: Expression of angiogenic regulators, VEGF and leptin, is regulated by the EGF/PI3K/STAT3 pathway in colorectal cancer cells. PMID: 19492417 Ref: Interleukin-6 trans-signaling and colonic cancer associated with inflammatory bowel disease. PMID: 19519447 Ref: Triptolide downregulates Rac1 and the JAK/STAT3 pathway and inhibits colitis-related colon cancer progression. PMID: 19561401 Ref: Mirk/Dyrk1B, a novel therapeutic target, mediates cell survival in non-small cell lung cancer cells. PMID: 19633423 Ref: A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses. PMID: 19701202 Ref: Synergistic effects of lovastatin and celecoxib on caveolin-1 and its down-stream signaling molecules: Implications for colon cancer prevention. PMID: 19787257 Ref: Inhibition of DNA methyltransferase induces G2 cell cycle arrest and apoptosis in human colorectal cancer cells via inhibition of JAK2/STAT3/STAT5 signalling. PMID: 20196786 Ref: Expression of the signal transducer and activator of transcription factor 3 and Janus kinase 3 in colorectal carcinomas, colonic adenomas and ulcerative colitis. PMID: 24842133 |
Ref: Disease-related expression of the IL6/STAT3/SOCS3 signalling pathway in ulcerative colitis and ulcerative colitis-related carcinogenesis. PMID: 19926618 Ref: Cucurbitacin B induces G2 arrest and apoptosis via a reactive oxygen species-dependent mechanism in human colon adenocarcinoma SW480 cells. PMID: 19937855 Ref: Involvement of the IL-22/REG Ialpha axis in ulcerative colitis. PMID: 20065946 Ref: Inflammatory bowel disease and intestinal cancer: a paradigm of the Yin-Yang interplay between inflammation and cancer. PMID: 20400974 Ref: [Effect of JAK2/STAT3/vimentin signaling pathway on proliferation and migration of human colon cancer cells]. PMID: 20422486 Ref: Janus-activated kinases and signal transducer and activator of transcription control tumor growth response to camptothecin in human colon cancer cells. PMID: 20534983 Ref: STAT3 implicated in the development of colon cancer: a step closer for targeted therapy? PMID: 20639089 Ref: Association of Shp2 with phosphorylated IL-22R1 is required for interleukin-22-induced MAP kinase activation. PMID: 20671117 Ref: Anticancer properties of the IL-12 family--focus on colorectal cancer. PMID: 20712574 Ref: A novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells. PMID: 20712901 Ref: Neutralization of interleukin (IL)-10 released by monocytes/macrophages enhances the up-regulatory effect of monocyte/macrophage-derived IL-6 on expressions of IL-6 and MUC1, and migration in HT-29 colon cancer cells. PMID: 20851386 Ref: Prognostic value of phosphorylated STAT3 in advanced rectal cancer: a study from 104 French patients included in the EORTC 22921 trial. PMID: 20876317 Ref: Toll-like receptor 2 signaling protects mice from tumor development in a mouse model of colitis-induced cancer. PMID: 20885960 Ref: Curcumin, the golden spice from Indian saffron, is a chemosensitizer and radiosensitizer for tumors and chemoprotector and radioprotector for normal organs. PMID: 20924967 Ref: A gene expression signature for chemoradiosensitivity of colorectal cancer cells. PMID: 20970032 Ref: Chronic inflammation, colorectal cancer and gene polymorphisms. PMID: 21088407 Ref: VEGF receptor signaling links inflammation and tumorigenesis in colitis-associated cancer. PMID: 21098094 |
Ref: DMBT1 is a novel gene induced by IL-22 in ulcerative colitis. PMID: 20824812 Ref: Cell-cell contacts induce STAT3 activity in colon carcinoma cells through an autocrine stimulation loop. PMID: 20830487 Ref: Aspirin promotes apoptosis in a murine model of colorectal cancer by mechanisms involving downregulation of IL-6-STAT3 signaling pathway. PMID: 20886344 Ref: Anti-interleukin-6 receptor antibody inhibits the progression in human colon carcinoma cells. PMID: 21114487 Ref: Diet-induced weight loss reduces colorectal inflammation: implications for colorectal carcinogenesis. PMID: 21147860 Ref: Cytokine disbalance in common human cancers. PMID: 21167870 Ref: Novel role for STAT3 in transcriptional regulation of NK immune cell targeting receptor MICA on cancer cells. PMID: 21257710 Ref: STAT3 expression, molecular features, inflammation patterns, and prognosis in a database of 724 colorectal cancers. PMID: 21310826 Ref: Leptin acts as a growth factor for colorectal tumours at stages subsequent to tumour initiation in murine colon carcinogenesis. PMID: 21406387 Ref: STAT3 controls matrix metalloproteinase-1 expression in colon carcinoma cells by both direct and AP-1-mediated interaction with the MMP-1 promoter. PMID: 21410405 Ref: IL-32gamma inhibits cancer cell growth through inactivation of NF-kappaB and STAT3 signals. PMID: 21423208 Ref: [Clinical significance of signal transduction and activators of transcription 3, E-cadherin and vimentin in colon cancer]. PMID: 21442485 Ref: A STAT3-decoy oligonucleotide induces cell death in a human colorectal carcinoma cell line by blocking nuclear transfer of STAT3 and STAT3-bound NF-kappaB. PMID: 21486470 Ref: Heparanase powers a chronic inflammatory circuit that promotes colitis-associated tumorigenesis in mice. PMID: 21490396 Ref: [Double suicide gene therapy with RNAi targeting to STAT3 inhibits the growth of colorectal carcinoma cells in vitro]. PMID: 21575474 Ref: Targeting colon cancer stem cells using a new curcumin analogue, GO-Y030. PMID: 21694723 Ref: Mesenchymal stem cells promote formation of colorectal tumors in mice. PMID: 21699785 Ref: Direct reprogramming of stem cell properties in colon cancer cells by CD44. PMID: 21701559 Ref: Role of the long form leptin receptor and of the STAT3 signaling pathway in colorectal cancer progression. PMID: 21720710 Ref: Disruption of the mouse protein tyrosine kinase 6 gene prevents STAT3 activation and confers resistance to azoxymethane. PMID: 21741923 Ref: STAT3 activation in skeletal muscle links muscle wasting and the acute phase response in cancer cachexia. PMID: 21799891 Ref: Cross-talk between phospho-STAT3 and PLCgamma1 plays a critical role in colorectal tumorigenesis. PMID: 21840932 Ref: Resveratrol potentiates the cytotoxic oxidative stress induced by chemotherapy in human colon cancer cells. PMID: 21865729 Ref: STAT3 is necessary for proliferation and survival in colon cancer-initiating cells. PMID: 21900397 Ref: Tumor-associated Macrophages (TAM) and Inflammation in Colorectal Cancer. PMID: 21909876 Ref: Toll-like receptor 4 variant D299G induces features of neoplastic progression in Caco-2 intestinal cells and is associated with advanced human colon cancer. PMID: 21920464 Ref: Cytokine induction of tumor necrosis factor receptor 2 is mediated by STAT3 in colon cancer cells. PMID: 21994466 Ref: Inhibition of STAT3 by RNA interference suppresses angiogenesis in colorectal carcinoma. PMID: 22030865 Ref: STAT3 signaling pathway is necessary for cell survival and tumorsphere forming capacity in ALDH(+)/CD133(+) stem cell-like human colon cancer cells. PMID: 22074823 Ref: Chemopreventive effects of NSAIDs on cytokines and transcription factors during the early stages of colorectal cancer. PMID: 22180364 Ref: Cellular signal transduction pathways by leptin in colorectal cancer tissue: preliminary results. PMID: 22363883 Ref: Tumor Necrosis Factor (TNF) and Chemokines in Colitis-Associated Cancer. PMID: 24212934 |
Ref: Trichostatin A, a histone deacetylase inhibitor, suppresses JAK2/STAT3 signaling via inducing the promoter-associated histone acetylation of SOCS1 and SOCS3 in human colorectal cancer cells. PMID: 21520296 Ref: A high-fat diet increases angiogenesis, solid tumor growth, and lung metastasis of CT26 colon cancer cells in obesity-resistant BALB/c mice. PMID: 21919080 Ref: Immunomodulatory action of dietary fish oil and targeted deletion of intestinal epithelial cell PPARdelta in inflammation-induced colon carcinogenesis. PMID: 21940900 Ref: Induction of tolerogenic dendritic cells by IL-6-secreting CT26 colon carcinoma. PMID: 21999714 Ref: Curcumin induces the differentiation of myeloid-derived suppressor cells and inhibits their interaction with cancer cells and related tumor growth. PMID: 22030090 Ref: Inhibition of JAK2/STAT3 signalling induces colorectal cancer cell apoptosis via mitochondrial pathway. PMID: 22050790 Ref: Colorectal cancer mouse models: integrating inflammation and the stroma. PMID: 22188027 Ref: Roles of STAT3 and ZEB1 proteins in E-cadherin down-regulation and human colorectal cancer epithelial-mesenchymal transition. PMID: 22205702 Ref: Pien Tze Huang inhibits tumor cell proliferation and promotes apoptosis via suppressing the STAT3 pathway in a colorectal cancer mouse model. PMID: 22218594 Ref: The inflammatory network in the gastrointestinal tumor microenvironment: lessons from mouse models. PMID: 22218775 Ref: Electrostatic assembly of a DNA superparamagnetic nano-tool for simultaneous intracellular delivery and in situ monitoring. PMID: 22248815 Ref: Therapeutic efficacy of CEP-33779, a novel selective JAK2 inhibitor, in a mouse model of colitis-induced colorectal cancer. PMID: 22334590 Ref: Role of IL-17A in the development of colitis-associated cancer. PMID: 22354874 Ref: The Immunohistochemical Expression of STAT3, Bcl-xL, and MMP-2 Proteins in Colon Adenoma and Adenocarcinoma. PMID: 22375170 Ref: Vanilloid receptor-1 regulates neurogenic inflammation in colon and protects mice from colon cancer. PMID: 22396497 Ref: Dual targeting of the epidermal growth factor receptor using the combination of cetuximab and erlotinib: preclinical evaluation and results of the phase II DUX study in chemotherapy-refractory, advanced colorectal cancer. PMID: 22412142 Ref: A STAT3-inhibitory hairpin decoy oligodeoxynucleotide discriminates between STAT1 and STAT3 and induces death in a human colon carcinoma cell line. PMID: 22423663 Ref: Gut microbiota accelerate tumor growth via c-jun and STAT3 phosphorylation in APCMin/+ mice. PMID: 22461519 Ref: Signal transducer and activator of transcription 3 (STAT3) protein suppresses adenoma-to-carcinoma transition in Apcmin/+ mice via regulation of Snail-1 (SNAI) protein stability. PMID: 22496368 Ref: STAT3 mutations correlated with hyper-IgE syndrome lead to blockage of IL-6/STAT3 signalling pathway. PMID: 22581330 Ref: Prevention of colitis-associated cancer: natural compounds that target the IL-6 soluble receptor. PMID: 22583410 Ref: Dynamic activation of the key pathways: linking colitis to colorectal cancer in a mouse model. PMID: 22610167 Ref: AS601245, an Anti-Inflammatory JNK Inhibitor, and Clofibrate Have a Synergistic Effect in Inducing Cell Responses and in Affecting the Gene Expression Profile in CaCo-2 Colon Cancer Cells. PMID: 22619672 Ref: Interleukin-6 signaling pathway in targeted therapy for cancer. PMID: 22651903 Ref: miR-21, miR-17 and miR-19a induced by phosphatase of regenerating liver-3 promote the proliferation and metastasis of colon cancer. PMID: 22677902 Ref: STAT3 repressed USP7 expression is crucial for colon cancer development. PMID: 22750444 Ref: Hedyotis diffusa Willd inhibits colorectal cancer growth in vivo via inhibition of STAT3 signaling pathway. PMID: 22754353 Ref: Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine. PMID: 22832932 Ref: Prohibitin attenuates colitis-associated tumorigenesis in mice by modulating p53 and STAT3 apoptotic responses. PMID: 22869582 Ref: Targeting of Noncanonical Wnt5a Signaling by AP-1 Blocker Dominant-Negative Jun When It Inhibits Skin Carcinogenesis. PMID: 22893789 Ref: EGF receptor signaling is essential for k-ras oncogene-driven pancreatic ductal adenocarcinoma. PMID: 22975375 Ref: Targeting protein tyrosine kinase 6 enhances apoptosis of colon cancer cells following DNA damage. PMID: 22989419 Ref: Pien Tze Huang suppresses IL-6-inducible STAT3 activation in human colon carcinoma cells through induction of SOCS3. PMID: 23027374 Ref: Interleukin-26, a highly cationic T-cell cytokine targeting epithelial cells. PMID: 23106140 Ref: Inhibition of Jak-STAT3 pathway enhances bufalin-induced apoptosis in colon cancer SW620 cells. PMID: 23110625 Ref: In vivo induction of apoptosis by fucoxanthin, a marine carotenoid, associated with down-regulating STAT3/EGFR signaling in sarcoma 180 (S180) xenografts-bearing mice. PMID: 23118721 Ref: Interleukin-6--a key regulator of colorectal cancer development. PMID: 23136553 Ref: Targeting COX-2/PGE(2) pathway in HIPK2 knockdown cancer cells: impact on dendritic cell maturation. PMID: 23144866 Ref: Dependency of colorectal cancer on a TGF-beta-driven program in stromal cells for metastasis initiation. PMID: 23153532 Ref: Relationship between expression and prognostic ability of PTEN, STAT3 and VEGF-C in colorectal cancer. PMID: 23170117 Ref: Expression of pSTAT3 in human colorectal carcinoma: correlation with clinico-pathological parameters. PMID: 23335526 Ref: Synthesis and Biological Evaluation of Novel N-phenyl-5-carboxamidyl Isoxazoles as Potential Chemotherapeutic Agents for Colon Cancer. PMID: 25285182 Ref: Inhibition of Stat3 by peptide aptamer rS3-PA enhances growth suppressive effects of irinotecan on colorectal cancer cells. PMID: 25436684 |
Ref: JAK/STAT/SOCS-signaling pathway and colon and rectal cancer. PMID: 22121102 Ref: Salutary effects of adiponectin on colon cancer: in vivo and in vitro studies in mice. PMID: 22735569 Ref: O-1602, an atypical cannabinoid, inhibits tumor growth in colitis-associated colon cancer through multiple mechanisms. PMID: 22965195 Ref: Impact of STAT3 phosphorylation on the clinical effectiveness of anti-EGFR-based therapy in patients with metastatic colorectal cancer. PMID: 23083634 Ref: Angiostatic properties of sulindac and celecoxib in the experimentally induced inflammatory colorectal cancer. PMID: 23149858 Ref: Histone deacetylase inhibitors induce CXCR4 mRNA but antagonize CXCR4 migration. PMID: 23192271 Ref: Implications of anti-cytokine therapy in colorectal cancer and autoimmune diseases. PMID: 23253923 Ref: Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer. PMID: 23273921 Ref: Mutant N-RAS protects colorectal cancer cells from stress-induced apoptosis and contributes to cancer development and progression. PMID: 23274911 Ref: Hedyotis diffusa Willd extract suppresses Sonic hedgehog signaling leading to the inhibition of colorectal cancer angiogenesis. PMID: 23291612 Ref: mTORC1 inhibition restricts inflammation-associated gastrointestinal tumorigenesis in mice. PMID: 23321674 Ref: Sphingosine 1-phosphate is a missing link between chronic inflammation and colon cancer. PMID: 23328479 Ref: Oct-4 is required for an antiapoptotic behavior of chemoresistant colorectal cancer cells enriched for cancer stem cells: effects associated with STAT3/Survivin. PMID: 23340171 Ref: Abrogation of galectin-4 expression promotes tumorigenesis in colorectal cancer. PMID: 23378274 Ref: IL-22 is related to development of human colon cancer by activation of STAT3. PMID: 23379788 Ref: Role of STAT3 and vitamin D receptor in EZH2-mediated invasion of human colorectal cancer. PMID: 23424038 Ref: Regulation of AKT gene expression by cisplatin. PMID: 23426872 Ref: Role of cytokines and Jak3/Stat3 signaling in the 1,2-dimethylhydrazine dihydrochloride-induced rat model of colon carcinogenesis: early target in the anticancer strategy. PMID: 23514809 Ref: Designer peptide antagonist of the leptin receptor with peripheral antineoplastic activity. PMID: 23567149 Ref: Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model. PMID: 23589566 Ref: Myeloid TGF-beta signaling contributes to colitis-associated tumorigenesis in mice. PMID: 23695722 Ref: Tying the knot between cytokine and toll-like receptor signaling in gastrointestinal tract cancers. PMID: 23710764 Ref: Both STAT1 and STAT3 are favourable prognostic determinants in colorectal carcinoma. PMID: 23756862 Ref: Spica prunellae promotes cancer cell apoptosis, inhibits cell proliferation and tumor angiogenesis in a mouse model of colorectal cancer via suppression of stat3 pathway. PMID: 23800091 Ref: Epithelial-mesenchymal transition and its role in the pathogenesis of colorectal cancer. PMID: 23803016 Ref: Functional role and therapeutic potential of the pim-1 kinase in colon carcinoma. PMID: 23814490 Ref: Oroxylin A inhibits colitis-associated carcinogenesis through modulating the IL-6/STAT3 signaling pathway. PMID: 23823704 Ref: Pien Tze Huang inhibits tumor angiogenesis in a mouse model of colorectal cancer via suppression of multiple cellular pathways. PMID: 23843018 Ref: Inhibition of the angiogenesis and growth of Aloin in human colorectal cancer in vitro and in vivo. PMID: 23848964 Ref: Ursolic acid promotes colorectal cancer cell apoptosis and inhibits cell proliferation via modulation of multiple signaling pathways. PMID: 23900560 Ref: JAB1 regulates unphosphorylated STAT3 DNA-binding activity through protein-protein interaction in human colon cancer cells. PMID: 23911788 Ref: MiR-124 suppresses growth of human colorectal cancer by inhibiting STAT3. PMID: 23940556 Ref: Activation state-dependent interaction between Galphaq subunits and the Fhit tumor suppressor. PMID: 23947369 Ref: STAT3 in epithelial cells regulates inflammation and tumor progression to malignant state in colon. PMID: 24027425 Ref: Ursolic acid inhibits colorectal cancer angiogenesis through suppression of multiple signaling pathways. PMID: 24042330 Ref: RKIP phosphorylation and STAT3 activation is inhibited by oxaliplatin and camptothecin and are associated with poor prognosis in stage II colon cancer patients. PMID: 24098947 Ref: Discovery of P3971 an orally efficacious novel anticancer agent targeting HIF-1alpha and STAT3 pathways. PMID: 24102269 Ref: omega3-PUFAs exert anti-inflammatory activity in visceral adipocytes from colorectal cancer patients. PMID: 24116229 Ref: Ursolic acid inhibits the growth of colon cancer-initiating cells by targeting STAT3. PMID: 24122993 Ref: TLR9 signaling in the tumor microenvironment initiates cancer recurrence after radiotherapy. PMID: 24154870 Ref: Adiponectin and metformin additively attenuate IL1beta-induced malignant potential of colon cancer. PMID: 24157941 Ref: Activation of pro-oncogenic pathways in colorectal hyperplastic polyps. PMID: 24209454 Ref: Dietary iron enhances colonic inflammation and IL-6/IL-11-Stat3 signaling promoting colonic tumor development in mice. PMID: 24223168 Ref: Characterization of the male ApcMin/+ mouse as a hypogonadism model related to cancer cachexia. PMID: 24285707 Ref: Honokiol as a Radiosensitizing Agent for Colorectal cancers. PMID: 24307888 Ref: In Vitro Investigation of the Immunomodulatory Potential of Probiotic Lactobacillus casei. PMID: 26782605 |
Ref: PTTG acts as a STAT3 target gene for colorectal cancer cell growth and motility. PMID: 23416975 Ref: STAT3 inhibition sensitizes colorectal cancer to chemoradiotherapy in vitro and in vivo. PMID: 23934972 Ref: Bone marrow-derived myofibroblasts promote colon tumorigenesis through the IL-6/JAK2/STAT3 pathway. PMID: 24145153 Ref: Sphingosine-1-phosphate in chronic intestinal inflammation and cancer. PMID: 24210073 Ref: Transcription control of DAPK. PMID: 24217921 Ref: Scutellaria Barbata D Don Inhibits Colorectal Cancer Growth via Suppression of Multiple Signaling Pathways. PMID: 24231788 Ref: Prolactin signaling enhances colon cancer stemness by modulating Notch signaling in a Jak2-STAT3/ERK manner. PMID: 24265293 Ref: Carbonic anhydrase IX is associated with early pulmonary spreading of primary colorectal carcinoma and tobacco smoking. PMID: 24321995 Ref: The IL-6/JAK/STAT3 pathway: potential therapeutic strategies in treating colorectal cancer (Review). PMID: 24430672 Ref: Feeding with olive oil attenuates inflammation in dextran sulfate sodium-induced colitis in rat. PMID: 24445043 Ref: Master regulator of intestinal disease: IL-6 in chronic inflammation and cancer development. PMID: 24447345 Ref: Easily controlled grafting of oligonucleotides on gammaFe2O3 nanoparticles: physicochemical characterization of DNA organization and biological activity studies. PMID: 24467641 Ref: Carnosol induces apoptosis through generation of ROS and inactivation of STAT3 signaling in human colon cancer HCT116 cells. PMID: 24481553 Ref: Fibroblast growth factor receptor 4 (FGFR4): a targetable regulator of drug resistance in colorectal cancer. PMID: 24503538 Ref: Novel mechanistic insights into ectodomain shedding of EGFR Ligands Amphiregulin and TGF-alpha: impact on gastrointestinal cancers driven by secondary bile acids. PMID: 24520077 Ref: Anti-EGFR therapeutic efficacy correlates directly with inhibition of STAT3 activity. PMID: 24556630 Ref: Signal transducer and activator of transcription 3 - a promising target in colitis-associated cancer. PMID: 24568457 Ref: IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis. PMID: 24642471 Ref: Embelin reduces colitis-associated tumorigenesis through limiting IL-6/STAT3 signaling. PMID: 24651526 Ref: Depletion of white adipose tissue in cancer cachexia syndrome is associated with inflammatory signaling and disrupted circadian regulation. PMID: 24667661 Ref: Aloperine induces G2/M phase cell cycle arrest and apoptosis in HCT116 human colon cancer cells. PMID: 24682388 Ref: Pyruvate kinase M2 facilitates colon cancer cell migration via the modulation of STAT3 signalling. PMID: 24686087 Ref: HIF-1alpha activation under glucose deprivation plays a central role in the acquisition of anti-apoptosis in human colon cancer cells. PMID: 24718784 Ref: c-Src drives intestinal regeneration and transformation. PMID: 24788409 Ref: IL-22(+)CD4(+) T cells promote colorectal cancer stemness via STAT3 transcription factor activation and induction of the methyltransferase DOT1L. PMID: 24816405 Ref: IL-22 gets to the stem of colorectal cancer. PMID: 24837100 Ref: Synthetic triterpenoid induces 15-PGDH expression and suppresses inflammation-driven colon carcinogenesis. PMID: 24837432 Ref: Thymoquinone induces apoptosis in human colon cancer HCT116 cells through inactivation of STAT3 by blocking JAK2- and Srcmediated phosphorylation of EGF receptor tyrosine kinase. PMID: 24890449 Ref: A microRNA 221- and 222-mediated feedback loop maintains constitutive activation of NFkappaB and STAT3 in colorectal cancer cells. PMID: 24931456 Ref: ADAM17-dependent c-MET-STAT3 signaling mediates resistance to MEK inhibitors in KRAS mutant colorectal cancer. PMID: 24931611 Ref: [Expressions of STAT3, p-STAT3 and E-cadherin in colorectal cancer and clinical implications]. PMID: 24953370 Ref: Conditional knockout of the leptin receptor in the colonic epithelium revealed the local effects of leptin receptor signaling in the progression of colonic tumors in mice. PMID: 24958593 Ref: Ubiquitin-specific peptidase USP22 negatively regulates the STAT signaling pathway by deubiquitinating SIRT1. PMID: 24969755 Ref: STAT3: An Anti-Invasive Factor in Colorectal Cancer? PMID: 24995503 Ref: Bone marrow mesenchymal stem cells ameliorate colitis-associated tumorigenesis in mice. PMID: 25010644 Ref: The role of corticotropin-releasing hormone receptor 1 in the development of colitis-associated cancer in mouse model. PMID: 25015995 Ref: Isoliquiritigenin, a flavonoid from licorice, blocks M2 macrophage polarization in colitis-associated tumorigenesis through downregulating PGE2 and IL-6. PMID: 25026504 Ref: Interleukin 22 protects colorectal cancer cells from chemotherapy by activating the STAT3 pathway and inducing autocrine expression of interleukin 8. PMID: 25063444 Ref: [Inflammation promotes the development of colitis-associated colorectal cancer]. PMID: 25070454 Ref: SHP-1 is a target of regorafenib in colorectal cancer. PMID: 25071018 Ref: Generation of ROS by CAY10598 leads to inactivation of STAT3 signaling and induction of apoptosis in human colon cancer HCT116 cells. PMID: 25096910 Ref: Genome-wide uncovering of STAT3-mediated miRNA expression profiles in colorectal cancer cell lines. PMID: 25126546 Ref: An analysis of genetic factors related to risk of inflammatory bowel disease and colon cancer. PMID: 25132422 Ref: STAT3 and sphingosine-1-phosphate in inflammation-associated colorectal cancer. PMID: 25132744 Ref: Tumor suppressor microRNA-27a in colorectal carcinogenesis and progression by targeting SGPP1 and Smad2. PMID: 25166914 Ref: Activation of the mTORC1 and STAT3 pathways promotes the malignant transformation of colitis in mice. PMID: 25174408 Ref: Stat3: friend or foe in colitis and colitis-associated cancer? PMID: 25185686 Ref: AZD1480, a JAK inhibitor, inhibits cell growth and survival of colorectal cancer via modulating the JAK2/STAT3 signaling pathway. PMID: 25216185 Ref: STAT3beta controls inflammatory responses and early tumor onset in skin and colon experimental cancer models. PMID: 25232490 Ref: Holo-retinol-binding protein and its receptor STRA6 drive oncogenic transformation. PMID: 25237067 Ref: Nicotine suppresses acute colitis and colonic tumorigenesis associated with chronic colitis in mice. PMID: 25258409 Ref: Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt-beta-catenin-mediated intestinal tumor growth and regeneration. PMID: 25270258 Ref: Cutting edge: STING mediates protection against colorectal tumorigenesis by governing the magnitude of intestinal inflammation. PMID: 25320273 Ref: HDAC8 and STAT3 repress BMF gene activity in colon cancer cells. PMID: 25321483 Ref: LIF negatively regulates tumour-suppressor p53 through Stat3/ID1/MDM2 in colorectal cancers. PMID: 25323535 Ref: Interleukin-6 mediated upregulation of CYP1B1 and CYP2E1 in colorectal cancer involves DNA methylation, miR27b and STAT3. PMID: 25333344 Ref: Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3-activated microRNAs. PMID: 25347472 Ref: STAT3 paradoxically stimulates beta-catenin expression but inhibits beta-catenin function. PMID: 25348333 Ref: A noncanonical Frizzled2 pathway regulates epithelial-mesenchymal transition and metastasis. PMID: 25417160 Ref: Detailed characterization of tumor infiltrating lymphocytes in two distinct human solid malignancies show phenotypic similarities. PMID: 25436113 Ref: Distinct behaviour of sorafenib in experimental cachexia-inducing tumours: the role of STAT3. PMID: 25436606 Ref: Microbiota organization is a distinct feature of proximal colorectal cancers. PMID: 25489084 Ref: Genome-wide identification of FoxO-dependent gene networks in skeletal muscle during C26 cancer cachexia. 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Ref: Adoptive transfer of regulatory T cells promotes intestinal tumorigenesis and is associated with decreased NK cells and IL-22 binding protein. PMID: 24797894 Ref: Th17-type cytokines, IL-6 and TNF-alpha synergistically activate STAT3 and NF-kB to promote colorectal cancer cell growth. PMID: 25174402 Ref: Effect of Smad3/4 on chemotherapeutic drug sensitivity in colorectal cancer cells. PMID: 25370208 Ref: HSP90 inhibitor NVP-AUY922 enhances TRAIL-induced apoptosis by suppressing the JAK2-STAT3-Mcl-1 signal transduction pathway in colorectal cancer cells. PMID: 25446253 Ref: Sunitinib prevents cachexia and prolongs survival of mice bearing renal cancer by restraining STAT3 and MuRF-1 activation in muscle. PMID: 25460504 Ref: Interleukin 6 alters localization of hMSH3, leading to DNA mismatch repair defects in colorectal cancer cells. PMID: 25461668 Ref: The traditional Chinese medicinal formula BDL301 suppresses tumor growth by inhibiting STAT3 pathway and inducing apoptosis in colorectal cancer cells. PMID: 25607688 Ref: Inhibition of STAT3/cyclinD1 pathway promotes chemotherapeutic sensitivity of colorectal caner. PMID: 25617735 Ref: Cucurbitacin I inhibits cell migration and invasion and enhances chemosensitivity in colon cancer. PMID: 25625299 Ref: The effectiveness of an anti-human IL-6 receptor monoclonal antibody combined with chemotherapy to target colon cancer stem-like cells. PMID: 25625841 Ref: Myeloid cell leukemia-1 is associated with tumor progression by inhibiting apoptosis and enhancing angiogenesis in colorectal cancer. PMID: 25628923 Ref: Potential anticancer properties and mechanisms of action of curcumin. PMID: 25667441 Ref: Synthesis of CDDO-amino acid-nitric oxide donor trihybrids as potential antitumor agents against both drug-sensitive and drug-resistant colon cancer. PMID: 25675144 Ref: Overexpression of B7-H3 augments anti-apoptosis of colorectal cancer cells by Jak2-STAT3. PMID: 25684945 Ref: Human papillomavirus infection correlates with inflammatory Stat3 signaling activity and IL-17 level in patients with colorectal cancer. PMID: 25706309 Ref: 15-Lipoxygenase-1 suppression of colitis-associated colon cancer through inhibition of the IL-6/STAT3 signaling pathway. PMID: 25713055 Ref: Phase I Study of OPB-31121, an Oral STAT3 Inhibitor, in Patients with Advanced Solid Tumors. PMID: 25715763 Ref: Impact of high glucose on metastasis of colon cancer cells. PMID: 25717237 Ref: Corrigendum. IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis. PMID: 25729853 Ref: A gp130-Src-YAP module links inflammation to epithelial regeneration. PMID: 25731159 Ref: Epithelial NAIPs protect against colonic tumorigenesis. PMID: 25732303 Ref: Aberrantly expressed Fra-1 by IL-6/STAT3 transactivation promotes colorectal cancer aggressiveness through epithelial-mesenchymal transition. PMID: 25750173 Ref: Anticancer effect of salidroside on colon cancer through inhibiting JAK2/STAT3 signaling pathway. PMID: 25755753 Ref: Curcumin targets in inflammation and cancer. PMID: 25772169 Ref: Expressional STAT3/STAT5 Ratio is an Independent Prognostic Marker in Colon Carcinoma. PMID: 25773877 Ref: Pyruvate kinase M2 accelerates pro-inflammatory cytokine secretion and cell proliferation induced by lipopolysaccharide in colorectal cancer. PMID: 25778902 Ref: Inhibition of Stat3 activation suppresses caspase-3 and the ubiquitin-proteasome system, leading to preservation of muscle mass in cancer cachexia. PMID: 25787076 Ref: Hedyotis diffusa Willd. extract suppresses proliferation and induces apoptosis via IL-6-inducible STAT3 pathway inactivation in human colorectal cancer cells. PMID: 25789077 Ref: Adipose-derived stem cells promote tumor initiation and accelerate tumor growth by interleukin-6 production. PMID: 25797257 Ref: HDAC Inhibition Overcomes Acute Resistance to MEK Inhibition in BRAF-Mutant Colorectal Cancer by Downregulation of c-FLIPL. PMID: 25813020 Ref: Cinnamaldehyde derivative (CB-PIC) sensitizes chemo-resistant cancer cells to drug-induced apoptosis via suppression of MDR1 and its upstream STAT3 and AKT signalling. PMID: 25833196 Ref: Interleukin-21 sustains inflammatory signals that contribute to sporadic colon tumorigenesis. PMID: 25839161 Ref: Dysregulation of over-expressed IL-32 in colorectal cancer induces metastasis. PMID: 25889282 Ref: Tumour pharmacodynamics and circulating cell free DNA in patients with refractory colorectal carcinoma treated with regorafenib. PMID: 25889309 Ref: Pharmacological inhibition of p38 MAPK reduces tumor growth in patient-derived xenografts from colon tumors. PMID: 25890501 Ref: Th22 cell accumulation is associated with colorectal cancer development. PMID: 25892871 Ref: Ubiquitin-specific peptidase 22 inhibits colon cancer cell invasion by suppressing the signal transducer and activator of transcription 3/matrix metalloproteinase 9 pathway. PMID: 25902005 Ref: Cryptotanshinone, a Stat3 inhibitor, suppresses colorectal cancer proliferation and growth in vitro. PMID: 25912550 Ref: Glutamate dehydrogenase is a novel prognostic marker and predicts metastases in colorectal cancer patients. PMID: 25947346 Ref: Berberine Inhibits Invasion and Metastasis of Colorectal Cancer Cells via COX-2/PGE2 Mediated JAK2/STAT3 Signaling Pathway. PMID: 25954974 Ref: Rational combination of MEK inhibitor and the STAT3 pathway modulator for the therapy in K-Ras mutated pancreatic and colon cancer cells. PMID: 25961376 Ref: Leptin activation of mTOR pathway in intestinal epithelial cell triggers lipid droplet formation, cytokine production and increased cell proliferation. PMID: 26017929 Ref: Prognostic Role of Phospho-STAT3 in Patients with Cancers of the Digestive System: A Systematic Review and Meta-Analysis. PMID: 26024373 Ref: ING4 enhances paclitaxel's effect on colorectal cancer growth in vitro and in vivo. PMID: 26045800 Ref: MicroRNA214 Is Associated With Progression of Ulcerative Colitis, and Inhibition Reduces Development of Colitis and Colitis-Associated Cancer in Mice. PMID: 26055138 Ref: Role of B7-H4 siRNA in Proliferation, Migration, and Invasion of LOVO Colorectal Carcinoma Cell Line. PMID: 26078947 Ref: Soluble IL6R represents a miR-34a target: potential implications for the recently identified IL-6R/STAT3/miR-34a feed-back loop. PMID: 26091352 Ref: A Key Role for Leukemia Inhibitory Factor in C26 Cancer Cachexia. PMID: 26092726 Ref: GPx2 Induction Is Mediated Through STAT Transcription Factors During Acute Colitis. PMID: 26115075 Ref: BMP-2 induces motility and invasiveness by promoting colon cancer stemness through STAT3 activation. PMID: 26124007 Ref: Effect of Rhizoma paridis total saponins on apoptosis of colorectal cancer cells and imbalance of the JAK/STAT3 molecular pathway induced by IL-6 suppression. PMID: 26125778 Ref: IL10R2 Overexpression Promotes IL22/STAT3 Signaling in Colorectal Carcinogenesis. PMID: 26130064 Ref: Myeloid STAT3 promotes formation of colitis-associated colorectal cancer in mice. PMID: 26137415 Ref: CCL2 Promotes Colorectal Carcinogenesis by Enhancing Polymorphonuclear Myeloid-Derived Suppressor Cell Population and Function. PMID: 26146082 Ref: B7H3 promotes cell migration and invasion through the Jak2/Stat3/MMP9 signaling pathway in colorectal cancer. PMID: 26151358 Ref: LIF is a new p53 negative regulator. PMID: 26161442 Ref: Molecular Response of Human Monocytes Following Interaction with Colon Cancer Cells by Pre-treatment with Low-dose Lipopolysaccharide. PMID: 26168489 Ref: Effects of growth arrest and DNA damage-inducible protein 34 (GADD34) on inflammation-induced colon cancer in mice. PMID: 26196182 Ref: Crosstalk between the TNF and IGF pathways enhances NF-kappaB activation and signaling in cancer cells. PMID: 26239406 Ref: The Mutant KRAS Gene Up-regulates BCL-XL Protein via STAT3 to Confer Apoptosis Resistance That Is Reversed by BIM Protein Induction and BCL-XL Antagonism. PMID: 26245900 Ref: Identification of Novel Biomarkers for Metastatic Colorectal Cancer Using Angiogenesis-Antibody Array and Intracellular Signaling Array. PMID: 26258407 Ref: Probing a 3,4'-bis-guanidinium diaryl derivative as an allosteric inhibitor of the Ras pathway. PMID: 26318998 Ref: Gallic acid suppresses inflammation in dextran sodium sulfate-induced colitis in mice: Possible mechanisms. PMID: 26319951 Ref: Human Colon Tumors Express a Dominant-Negative Form of SIGIRR That Promotes Inflammation and Colitis-Associated Colon Cancer in Mice. PMID: 26344057 Ref: Dietary cocoa inhibits colitis associated cancer: a crucial involvement of the IL-6/STAT3 pathway. PMID: 26355019 Ref: Berberine may rescue Fusobacterium nucleatum-induced colorectal tumorigenesis by modulating the tumor microenvironment. PMID: 26397137 Ref: Cellular signaling pathways implicated in metastasis of colorectal cancer and the associated targeted agents. PMID: 26414153 Ref: LPA Induces Colon Cancer Cell Proliferation through a Cooperation between the ROCK and STAT-3 Pathways. PMID: 26418031 Ref: Tumor-selective proteotoxicity of verteporfin inhibits colon cancer progression independently of YAP1. PMID: 26443705 Ref: Mechanisms linking obesity to altered metabolism in mice colon carcinogenesis. PMID: 26472027 Ref: Withaferin-A Inhibits Colon Cancer Cell Growth by Blocking STAT3 Transcriptional Activity. PMID: 26473157 Ref: (E)-4-(3-(3,5-dimethoxyphenyl)allyl)-2-methoxyphenol inhibits growth of colon tumors in mice. PMID: 26474284 Ref: Pharmacological Targeting SHP-1-STAT3 Signaling Is a Promising Therapeutic Approach for the Treatment of Colorectal Cancer. PMID: 26476076 Ref: Diminished expression of CRHR2 in human colon cancer promotes tumor growth and EMT via persistent IL-6/Stat3 signaling. PMID: 26495412 Ref: Molecular profiling of cetuximab and bevacizumab treatment of colorectal tumours reveals perturbations in metabolic and hypoxic response pathways. PMID: 26517691 Ref: Nuclear PKM2 contributes to gefitinib resistance via upregulation of STAT3 activation in colorectal cancer. PMID: 26542452 Ref: IL-6/STAT3/SOCS3 signaling pathway playing a regulatory role in ulcerative colitis carcinogenesis. PMID: 26550113 Ref: Evodiamine Induces Apoptosis and Inhibits Migration of HCT-116 Human Colorectal Cancer Cells. PMID: 26580615 Ref: Salternamide A Suppresses Hypoxia-Induced Accumulation of HIF-1alpha and Induces Apoptosis in Human Colorectal Cancer Cells. PMID: 26610526 Ref: IKKbeta in intestinal mesenchymal cells promotes initiation of colitis-associated cancer. PMID: 26621453 Ref: Scutellaria barbata D. Don inhibits growth and induces apoptosis by suppressing IL-6-inducible STAT3 pathway activation in human colorectal cancer cells. PMID: 26622533 Ref: Hes1 Increases the Invasion Ability of Colorectal Cancer Cells via the STAT3-MMP14 Pathway. PMID: 26650241 Ref: Interleukin-6 trans-signaling increases the expression of carcinoembryonic antigen-related cell adhesion molecules 5 and 6 in colorectal cancer cells. PMID: 26673628 Ref: Multiple pathways regulate Cten in colorectal cancer without a Tensin switch. PMID: 26852686 Ref: Sphingosine-1-phosphate in inflammatory bowel disease and colitis-associated colon cancer: the fat's in the fire. PMID: 27011900 Ref: Modulation of tumorigenesis by the pro-inflammatory microRNA miR-301a in mouse models of lung cancer and colorectal cancer. PMID: 27462406 Ref: IL-11 induces differentiation of myeloid-derived suppressor cells through activation of STAT3 signalling pathway. PMID: 28781374 |
Ref: PAC exhibits potent anti-colon cancer properties through targeting cyclin D1 and suppressing epithelial-to-mesenchymal transition. PMID: 25641341 Ref: Carcinoembryonic Antigen Cell Adhesion Molecule 1 long isoform modulates malignancy of poorly differentiated colon cancer cells. PMID: 25666195 Ref: Antagonizing pathways leading to differential dynamics in colon carcinogenesis in Shugoshin1 (Sgo1)-haploinsufficient chromosome instability model. PMID: 25773652 Ref: Targeting JAK kinase in solid tumors: emerging opportunities and challenges. PMID: 25982279 Ref: Novel evidence for an oncogenic role of microRNA-21 in colitis-associated colorectal cancer. PMID: 25994220 Ref: Carnosic acid inhibits STAT3 signaling and induces apoptosis through generation of ROS in human colon cancer HCT116 cells. PMID: 26152521 Ref: Treatment with cucurbitacin B alone and in combination with gefitinib induces cell cycle inhibition and apoptosis via EGFR and JAK/STAT pathway in human colorectal cancer cell lines. PMID: 26183715 Ref: Anti-Warburg effect of rosmarinic acid via miR-155 in colorectal carcinoma cells. PMID: 26340059 Ref: Targeting colorectal cancer via its microenvironment by inhibiting IGF-1 receptor-insulin receptor substrate and STAT3 signaling. PMID: 26364612 Ref: Genetic variants in IL-6/JAK/STAT3 pathway and the risk of CRC. PMID: 26638167 Ref: Interleukin-6 increases expression of serine protease inhibitor Kazal type 1 through STAT3 in colorectal adenocarcinoma. PMID: 26663388 Ref: Sonic hedgehog inhibitors prevent colitis-associated cancer via orchestrated mechanisms of IL-6/gp130 inhibition, 15-PGDH induction, Bcl-2 abrogation, and tumorsphere inhibition. PMID: 26716648 Ref: IL-6 down-regulates HLA class II expression and IL-12 production of human dendritic cells to impair activation of antigen-specific CD4(+) T cells. PMID: 26759006 Ref: Colorectal cancer cell-derived interleukin-6 enhances the phagocytic capacity and migration of THP-1 cells. PMID: 26775116 Ref: Eriocalyxin B blocks human SW1116 colon cancer cell proliferation, migration, invasion, cell cycle progression and angiogenesis via the JAK2/STAT3 signaling pathway. PMID: 26795301 Ref: G-CSF is a key modulator of MDSC and could be a potential therapeutic target in colitis-associated colorectal cancers. PMID: 26797765 Ref: IL-32theta inhibits stemness and epithelial-mesenchymal transition of cancer stem cells via the STAT3 pathway in colon cancer. PMID: 26824417 Ref: IGF/STAT3/NANOG/Slug Signaling Axis Simultaneously Controls Epithelial-Mesenchymal Transition and Stemness Maintenance in Colorectal Cancer. PMID: 26840943 Ref: Targeted deletion of miR-139-5p activates MAPK, NF-kappaB and STAT3 signaling and promotes intestinal inflammation and colorectal cancer. PMID: 26859226 Ref: Deletion of Na+/H+ exchanger regulatory factor 2 represses colon cancer progress by suppression of Stat3 and CD24. PMID: 26867566 Ref: HIF-3alpha1 promotes colorectal tumor cell growth by activation of JAK-STAT3 signaling. PMID: 26871465 Ref: MiR-874 inhibits cell growth and induces apoptosis by targeting STAT3 in human colorectal cancer cells. PMID: 26875895 Ref: Redundant Innate and Adaptive Sources of IL17 Production Drive Colon Tumorigenesis. PMID: 26880802 Ref: A novel small molecule STAT3 inhibitor, LY5, inhibits cell viability, colony formation, and migration of colon and liver cancer cells. PMID: 26883202 Ref: PDCD4 Deficiency Aggravated Colitis and Colitis-associated Colorectal Cancer Via Promoting IL-6/STAT3 Pathway in Mice. PMID: 26891257 Ref: Combination of metformin and 5-aminosalicylic acid cooperates to decrease proliferation and induce apoptosis in colorectal cancer cell lines. PMID: 26896068 Ref: The aspirin-induced long non-coding RNA OLA1P2 blocks phosphorylated STAT3 homodimer formation. PMID: 26898989 Ref: Smyd3 Is a Transcriptional Potentiator of Multiple Cancer-Promoting Genes and Required for Liver and Colon Cancer Development. PMID: 26908355 Ref: Jak-STAT3 pathway triggers DICER1 for proteasomal degradation by ubiquitin ligase complex of CUL4A(DCAF1) to promote colon cancer development. PMID: 26965998 Ref: The Innate Immune Receptor NLRX1 Functions as a Tumor Suppressor by Reducing Colon Tumorigenesis and Key Tumor-Promoting Signals. PMID: 26971998 Ref: STAT3-dependent TXNDC17 expression mediates Taxol resistance through inducing autophagy in human colorectal cancer cells. PMID: 26976343 Ref: Non-Photoinduced Biological Properties of Verteporfin. PMID: 26980565 Ref: Kinase-Dependent and -Independent Roles for PTK6 in Colon Cancer. PMID: 26983689 Ref: IL-6 Inhibition Reduces STAT3 Activation and Enhances the Antitumor Effect of Carboplatin. PMID: 27006530 Ref: Tumor suppressor PRSS8 targets Sphk1/S1P/Stat3/Akt signaling in colorectal cancer. PMID: 27050145 Ref: Inflammatory bowel disease, colorectal cancer and type 2 diabetes mellitus: The links. PMID: 27051585 Ref: CRNDE Promotes Malignant Progression of Glioma by Attenuating miR-384/PIWIL4/STAT3 Axis. PMID: 27058823 Ref: Oleanolic acid inhibits colorectal cancer angiogenesis in vivo and in vitro via suppression of STAT3 and Hedgehog pathways. PMID: 27108756 Ref: Chemopreventive Effect of Dietary Glutamineon Colitis-Associated Colorectal Cancer Is Associated with Modulation of the DEPTOR/mTOR Signaling Pathway. PMID: 27144580 Ref: BRG1 targeting STAT3/VEGFC signaling regulates lymphangiogenesis in colorectal cancer. PMID: 27145366 Ref: IRAK-M Expression in Tumor Cells Supports Colorectal Cancer Progression through Reduction of Antimicrobial Defense and Stabilization of STAT3. PMID: 27150039 Ref: Dietary peptides from the non-digestible fraction of Phaseolus vulgaris L. decrease angiotensin II-dependent proliferation in HCT116 human colorectal cancer cells through the blockade of the renin-angiotensin system. PMID: 27156533 Ref: Multifaceted Role of IRAK-M in the Promotion of Colon Carcinogenesis via Barrier Dysfunction and STAT3 Oncoprotein Stabilization in Tumors. PMID: 27165738 Ref: The ratio of STAT1 to STAT3 expression is a determinant of colorectal cancer growth. PMID: 27191495 Ref: The long noncoding RNA CASC2 functions as a competing endogenous RNA by sponging miR-18a in colorectal cancer. PMID: 27198161 Ref: Keratin 8-deletion induced colitis predisposes to murine colorectal cancer enforced by the inflammasome and IL-22 pathway. PMID: 27234655 Ref: Salmonella Protein AvrA Activates the STAT3 Signaling Pathway in Colon Cancer. PMID: 27237322 Ref: Epstein-Barr Virus-Induced Gene 3 (EBI3) Blocking Leads to Induce Antitumor Cytotoxic T Lymphocyte Response and Suppress Tumor Growth in Colorectal Cancer by Bidirectional Reciprocal-Regulation STAT3 Signaling Pathway. PMID: 27247488 Ref: Upregulated STAT3 and RhoA signaling in colorectal cancer (CRC) regulate the invasion and migration of CRC cells. PMID: 27249601 Ref: MiR-205 and MiR-373 Are Associated with Aggressive Human Mucinous Colorectal Cancer. PMID: 27271572 Ref: Annexin A2 Coordinates STAT3 to Regulate the Invasion and Migration of Colorectal Cancer Cells In Vitro. PMID: 27274723 Ref: Combination treatment with flavonoid morin and telomerase inhibitor MST312 reduces cancer stem cell traits by targeting STAT3 and telomerase. PMID: 27279256 Ref: Suspension survival mediated by PP2A-STAT3-Col XVII determines tumour initiation and metastasis in cancer stem cells. PMID: 27306323 Ref: Valosin-containing protein (VCP) promotes the growth, invasion, and metastasis of colorectal cancer through activation of STAT3 signaling. PMID: 27344168 Ref: Critical function of the necroptosis adaptor RIPK3 in protecting from intestinal tumorigenesis. PMID: 27344176 Ref: [Effect of interleukin 17 on invasion of human colon cancer cells]. PMID: 27353107 Ref: Histone deacetylase inhibitors regulate P-gp expression in colorectal cancer via transcriptional activation and mRNA stabilization. PMID: 27409663 Ref: Aberrant Expression of CUL4A Is Associated with IL-6/ STAT3 Activation in Colorectal Cancer Progression. PMID: 27418574 Ref: RNA interference against TRIM29 inhibits migration and invasion of colorectal cancer cells. PMID: 27430345 Ref: Visceral fat adipocytes from obese and colorectal cancer subjects exhibit distinct secretory and omega6 polyunsaturated fatty acid profiles and deliver immunosuppressive signals to innate immunity cells. PMID: 27494857 Ref: CD24 promoted cancer cell angiogenesis via Hsp90-mediated STAT3/VEGF signaling pathway in colorectal cancer. PMID: 27494878 Ref: The Role of p-STAT3 as a Prognostic and Clinicopathological Marker in Colorectal Cancer: A Systematic Review and Meta-Analysis. PMID: 27504822 Ref: DDA suppresses angiogenesis and tumor growth of colorectal cancer in vivo through decreasing VEGFR2 signaling. PMID: 27517319 Ref: Carcinoma-associated fibroblasts affect sensitivity to oxaliplatin and 5FU in colorectal cancer cells. PMID: 27517495 Ref: Iron Uptake via DMT1 Integrates Cell Cycle with JAK-STAT3 Signaling to Promote Colorectal Tumorigenesis. PMID: 27546461 Ref: Ginsenoside 20(S)-Rh2 exerts anti-cancer activity through targeting IL-6-induced JAK2/STAT3 pathway in human colorectal cancer cells. PMID: 27566200 Ref: Overexpression of gelsolin reduces the proliferation and invasion of colon carcinoma cells. PMID: 27573444 Ref: SHP-2 phosphatase contributes to KRAS-driven intestinal oncogenesis but prevents colitis-associated cancer development. PMID: 27582544 Ref: Th22 cells control colon tumorigenesis through STAT3 and Polycomb Repression complex 2 signaling. PMID: 27622053 Ref: miR-181b functions as an oncomiR in colorectal cancer by targeting PDCD4. PMID: 27647131 Ref: Garcinol and Its Role in Chronic Diseases. PMID: 27671827 Ref: Elevated level of interleukin-35 in colorectal cancer induces conversion of T cells into iTr35 by activating STAT1/STAT3. PMID: 27682874 Ref: Reduced Representation Bisulfite Sequencing Determination of Distinctive DNA Hypermethylated Genes in the Progression to Colon Cancer in African Americans. PMID: 27688749 Ref: Combined application of anti-VEGF and anti-EGFR attenuates the growth and angiogenesis of colorectal cancer mainly through suppressing AKT and ERK signaling in mice model. PMID: 27729020 Ref: Foxp3 expression in CD4(+)CD25(+)Foxp3(+) regulatory T cells promotes development of colorectal cancer by inhibiting tumor immunity. PMID: 27752897 Ref: microRNA-146a inhibits proliferation, migration and invasion of human cervical and colorectal cancer cells. PMID: 27769860 Ref: miR-146a Polymorphism (rs2910164) Predicts Colorectal Cancer Patients' Susceptibility to Liver Metastasis. PMID: 27824903 Ref: The Daniel K. Inouye College of Pharmacy Scripts: Poha Berry (Physalis peruviana) with Potential Anti-inflammatory and Cancer Prevention Activities. PMID: 27920947 Ref: [Effect of jianpi-jiedu formula on tumor angiogenesis-relevant genes expression in colorectal cancer]. PMID: 28070042 |
Ref: delta- and gamma-tocopherols inhibit phIP/DSS-induced colon carcinogenesis by protection against early cellular and DNA damages. PMID: 27175800 Ref: The AIM2 inflammasome is a central regulator of intestinal homeostasis through the IL-18/IL-22/STAT3 pathway. PMID: 27524110 Ref: Stat3 contributes to cancer progression by regulating Jab1/Csn5 expression. PMID: 27524414 Ref: Signal Transduction and Activator of Transcription-3 (STAT3) in Patients with Colorectal Cancer: Associations with the Phenotypic Features of the Tumor and Host. PMID: 27678454 Ref: Cooperation between the bacterial-derived short-chain fatty acid butyrate and interleukin-22 detected in human Caco2 colon epithelial/carcinoma cells. PMID: 27801948 Ref: HSP110 promotes colorectal cancer growth through STAT3 activation. PMID: 27819670 Ref: Silencing of long non-coding RNA SBDSP1 suppresses tumor growth and invasion in colorectal cancer. PMID: 27890432 Ref: The DEAD box protein p68: a novel coactivator of Stat3 in mediating oncogenesis. PMID: 27941883 Ref: Niclosamide Inhibits Oxaliplatin Neurotoxicity while Improving Colorectal Cancer Therapeutic Response. PMID: 27980107 Ref: SRI36160 is a specific inhibitor of Wnt/beta-catenin signaling in human pancreatic and colorectal cancer cells. PMID: 28043913 Ref: Inhibition of Stat3 signaling pathway by nifuroxazide improves antitumor immunity and impairs colorectal carcinoma metastasis. PMID: 28055016 Ref: RNA virus receptor Rig-I monitors gut microbiota and inhibits colitis-associated colorectal cancer. PMID: 28057020 Ref: ALOX15 as a suppressor of inflammation and cancer: Lost in the link. PMID: 28089732 Ref: Correlation between microvascular characteristics and the expression of MVD, IGF-1 and STAT3 in the development of colonic polyps carcinogenesis. PMID: 28123467 Ref: YAP-IL-6ST autoregulatory loop activated on APC loss controls colonic tumorigenesis. PMID: 28130546 Ref: Steering of carcinoma progression by the YIN/YANG interaction of STAT1/STAT3. PMID: 28154246 Ref: The oncoprotein gankyrin promotes the development of colitis-associated cancer through activation of STAT3. PMID: 28160571 Ref: Salinomycin Abolished STAT3 and STAT1 Interactions and Reduced Telomerase Activity in Colorectal Cancer Cells. PMID: 28179289 Ref: microRNA-375 inhibits colorectal cancer cells proliferation by downregulating JAK2/STAT3 and MAP3K8/ERK signaling pathways. PMID: 28186962 Ref: STAT3 activation in infection and infection-associated cancer. PMID: 28223148 Ref: Oncogenic role of rab escort protein 1 through EGFR and STAT3 pathway. PMID: 28230863 Ref: Lithocholic Acid Stimulates IL-8 Expression in Human Colorectal Cancer Cells Via Activation of Erk1/2 MAPK and Suppression of STAT3 Activity. PMID: 28247965 Ref: Chronic inflammation confers to the metabolic reprogramming associated with tumorigenesis of colorectal cancer. PMID: 28278072 Ref: Immunomodulating and Immunoresistance Properties of Cancer-Initiating Cells: Implications for the Clinical Success of Immunotherapy. PMID: 28287848 Ref: Helicteric Acid, Oleanic Acid, and Betulinic Acid, Three Triterpenes from Helicteres angustifolia L., Inhibit Proliferation and Induce Apoptosis in HT-29 Colorectal Cancer Cells via Suppressing NF-kappaB and STAT3 Signaling. PMID: 28331523 Ref: Syndecan-1 deficiency promotes tumor growth in a murine model of colitis-induced colon carcinoma. PMID: 28350804 Ref: Niclosamide inhibition of STAT3 synergizes with erlotinib in human colon cancer. PMID: 28367059 Ref: Chitosan promotes cancer progression and stem cell properties in association with Wnt signaling in colon and hepatocellular carcinoma cells. PMID: 28367998 Ref: 4PD Functionalized Dendrimers: A Flexible Tool for In Vivo Gene Silencing of Tumor-Educated Myeloid Cells. PMID: 28396317 Ref: EGFR in Tumor-Associated Myeloid Cells Promotes Development of Colorectal Cancer in Mice and Associates With Outcomes of Patients. PMID: 28400195 Ref: Histidine decarboxylase (HDC)-expressing granulocytic myeloid cells induce and recruit Foxp3(+) regulatory T cells in murine colon cancer. PMID: 28405523 Ref: Impact of Acetazolamide, a Carbonic Anhydrase Inhibitor, on the Development of Intestinal Polyps in Min Mice. PMID: 28420165 Ref: Antagonistic Effects of p53 and HIF1A on microRNA-34a Regulation of PPP1R11 and STAT3 and Hypoxia-induced Epithelial to Mesenchymal Transition in Colorectal Cancer Cells. PMID: 28435028 Ref: Identification of NCK1 as a novel downstream effector of STAT3 in colorectal cancer metastasis and angiogenesis. PMID: 28455144 Ref: Panitumumab interaction with TAS-102 leads to combinational anticancer effects via blocking of EGFR-mediated tumor response to trifluridine. PMID: 28486761 Ref: MicroRNA-1299 is a negative regulator of STAT3 in colon cancer. PMID: 28498395 Ref: Lactobacillus rhamnosus ATCC 7469 exopolysaccharides synergizes with low level ionizing radiation to modulate signaling molecular targets in colorectal carcinogenesis in rats. PMID: 28554134 Ref: Silencing of type Igamma phosphatidylinositol phosphate kinase suppresses ovarian cancer cell proliferation, migration and invasion. PMID: 28560454 Ref: Card9-dependent IL-1beta regulates IL-22 production from group 3 innate lymphoid cells and promotes colitis-associated cancer. PMID: 28586167 Ref: Maintenance of cancer stemness by miR-196b-5p contributes to chemoresistance of colorectal cancer cells via activating STAT3 signaling pathway. PMID: 28591704 Ref: Prognostic significance of SOCS3 and its biological function in colorectal cancer. PMID: 28603075 Ref: CRH promotes human colon cancer cell proliferation via IL-6/JAK2/STAT3 signaling pathway and VEGF-induced tumor angiogenesis. PMID: 28618089 Ref: 18 beta-glycyrrhetinic acid exhibits potent antitumor effects against colorectal cancer via inhibition of cell proliferation and migration. PMID: 28656212 Ref: Cetuximab promotes SN38 sensitivity via suppression of heat shock protein 27 in colorectal cancer cells with wild-type RAS. PMID: 28656305 Ref: Proinflammatory Cytokines IL-6 and TNF-alpha Increased Telomerase Activity through NF-kappaB/STAT1/STAT3 Activation, and Withaferin A Inhibited the Signaling in Colorectal Cancer Cells. PMID: 28676732 Ref: Pan-cancer EMT-signature identifies RBM47 down-regulation during colorectal cancer progression. PMID: 28680090 Ref: RBP4-STRA6 Pathway Drives Cancer Stem Cell Maintenance and Mediates High-Fat Diet-Induced Colon Carcinogenesis. PMID: 28689994 Ref: Inhibition of IL-6/STAT3 signaling in human cancer cells using Evista. PMID: 28711499 Ref: Anticarcinogenic Effects of Dried Citrus Peel in Colon Carcinogenesis Due to Inhibition of Oxidative Stress. PMID: 28718722 Ref: Mucin 2 silencing promotes colon cancer metastasis through interleukin-6 signaling. PMID: 28725043 Ref: Interleukin-6/STAT3 signaling as a promising target to improve the efficacy of cancer immunotherapy. PMID: 28749573 Ref: Loss of claudin-3 expression induces IL6/gp130/Stat3 signaling to promote colon cancer malignancy by hyperactivating Wnt/beta-catenin signaling. PMID: 28783170 Ref: Secretory RAB GTPase 3C modulates IL6-STAT3 pathway to promote colon cancer metastasis and is associated with poor prognosis. PMID: 28784136 Ref: R-spondin 2 promotes proliferation and migration via the Wnt/beta-catenin pathway in human hepatocellular carcinoma. PMID: 28789406 Ref: Effects of 17-allylamino-17-demethoxygeldanamycin on the induction of apoptosis and cell cycle arrest in HCT-116 cells. PMID: 28789442 Ref: Epigenetic regulation of the extrinsic oncosuppressor PTX3 gene in inflammation and cancer. PMID: 28811977 Ref: The Role of Proinflammatory Pathways in the Pathogenesis of Colitis-Associated Colorectal Cancer. PMID: 28852270 Ref: Stress responsive miR-31 is a major modulator of mouse intestinal stem cells during regeneration and tumorigenesis. PMID: 28870287 Ref: alpha7 nicotinic acetylcholine receptor in tumor-associated macrophages inhibits colorectal cancer metastasis through the JAK2/STAT3 signaling pathway. PMID: 28901507 Ref: The Immune-microenvironment Confers Chemoresistance of Colorectal Cancer through Macrophage-Derived IL6. PMID: 28928161 Ref: miR-148a inhibits colitis and colitis-associated tumorigenesis in mice. PMID: 28960206 Ref: Combination curcumin and (-)-epigallocatechin-3-gallate inhibits colorectal carcinoma microenvironment-induced angiogenesis by JAK/STAT3/IL-8 pathway. PMID: 28967875 Ref: Ginsenosides Rb3 and Rd reduce polyps formation while reinstate the dysbiotic gut microbiota and the intestinal microenvironment in Apc(Min/+) mice. PMID: 28970547 Ref: IL-8 Is Involved in Estrogen-Related Receptor alpha-Regulated Proliferation and Migration of Colorectal Cancer Cells. PMID: 28993941 Ref: miR-214 activates TP53 but suppresses the expression of RELA, CTNNB1, and STAT3 in human cervical and colorectal cancer cells. PMID: 29023799 Ref: Identification of zinc finger protein of the cerebellum 5 as a survival factor of prostate and colorectal cancer cells. PMID: 29024195 Ref: Combination of FGFR4 inhibitor Blu9931 and 5-fluorouracil effects on the biological characteristics of colorectal cancer cells. PMID: 29048661 Ref: Fasting inhibits colorectal cancer growth by reducing M2 polarization of tumor-associated macrophages. PMID: 29088814 Ref: S-adenosylmethionine and methylthioadenosine inhibit cancer metastasis by targeting microRNA 34a/b-methionine adenosyltransferase 2A/2B axis. PMID: 29108270 Ref: JAB1-STAT3 activation loop is associated with recurrence following 5-fluorouracil-based adjuvant chemotherapy in human colorectal cancer. PMID: 29113268 Ref: MiR-216b functions as a tumor suppressor by targeting HMGB1-mediated JAK2/STAT3 signaling way in colorectal cancer. PMID: 29119054 Ref: IL-32theta: a recently identified anti-inflammatory variant of IL-32 and its preventive role in various disorders and tumor suppressor activity. PMID: 29218075 Ref: SHP2 associates with nuclear localization of STAT3: significance in progression and prognosis of colorectal cancer. PMID: 29242509 Ref: Inhibition of autophagy enhances synergistic effects of Salidroside and anti-tumor agents against colorectal cancer. PMID: 29246220 Ref: MiR-92a promotes stem cell-like properties by activating Wnt/beta-catenin signaling in colorectal cancer. PMID: 29254202 Ref: EphA2 signaling is impacted by carcinoembryonic antigen cell adhesion molecule 1-L expression in colorectal cancer liver metastasis in a cell context-dependent manner. PMID: 29262644 Ref: Curcumin-Free Turmeric Exhibits Activity against Human HCT-116 Colon Tumor Xenograft: Comparison with Curcumin and Whole Turmeric. PMID: 29311914 Ref: Phosphorylation of STAT3 Promotes Vasculogenic Mimicry by Inducing Epithelial-to-Mesenchymal Transition in Colorectal Cancer. PMID: 29333928 Ref: Hedyotis diffusa willd extract suppresses colorectal cancer growth through multiple cellular pathways. PMID: 29344262 |
Ref: Scorpion Venom Causes Upregulation of p53 and Downregulation of Bcl-xL and BID Protein Expression by Modulating Signaling Proteins Erk(1/2) and STAT3, and DNA Damage in Breast and Colorectal Cancer Cell Lines. PMID: 28438053 Ref: G protein-coupled receptor GPR55 promotes colorectal cancer and has opposing effects to cannabinoid receptor 1. PMID: 28875496 Ref: Macrophage depletion using clodronate liposomes decreases tumorigenesis and alters gut microbiota in the AOM/DSS mouse model of colon cancer. PMID: 29025731 Ref: Molecular targets for the therapy of cancer associated with metabolic syndrome (transcription and growth factors). PMID: 29115033 Ref: Pyrin Inflammasome Regulates Tight Junction Integrity to Restrict Colitis and Tumorigenesis. PMID: 29203393 Ref: Novel 1,4-benzothazines obliterate COX-2 mediated JAK-2/STAT-3 signals with potential regulation of oxidative and metabolic stress during colorectal cancer. PMID: 29229353 Ref: RING-Finger Protein 6 Amplification Activates JAK/STAT3 Pathway by Modifying SHP-1 Ubiquitylation and Associates with Poor Outcome in Colorectal Cancer. PMID: 29288235 Ref: Human colorectal cancer-derived mesenchymal stem cells promote colorectal cancer progression through IL-6/JAK2/STAT3 signaling. PMID: 29348540 Ref: Chemoprevention of colorectal cancer by black raspberry anthocyanins involved the modulation of gut microbiota and SFRP2 demethylation. PMID: 29361151 Ref: P16 promotes the growth and mobility potential of breast cancer both in vitro and in vivo: the key role of the activation of IL-6/JAK2/STAT3 signaling. PMID: 29388151 Ref: Napabucasin versus placebo in refractory advanced colorectal cancer: a randomised phase 3 trial. PMID: 29397354 Ref: Bacteroides fragilis Toxin Coordinates a Pro-carcinogenic Inflammatory Cascade via Targeting of Colonic Epithelial Cells. PMID: 29398651 Ref: Serine/Threonine Kinase 35, a Target Gene of STAT3, Regulates the Proliferation and Apoptosis of Osteosarcoma Cells. PMID: 29414823 Ref: Dihydroartemisinin increases apoptosis of colon cancer cells through targeting Janus kinase 2/signal transducer and activator of transcription 3 signaling. PMID: 29434895 Ref: A novel small molecular STAT3 inhibitor, 5Br-6b, induces apoptosis and inhibits migration in colorectal cancer cells. PMID: 29438179 Ref: LncRNA AB073614 induces epithelial- mesenchymal transition of colorectal cancer cells via regulating the JAK/STAT3 pathway. PMID: 29439310 Ref: 6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid attenuates colon carcinogenesis via blockade of IL-6 mediated signals. PMID: 29448205 Ref: Natural small molecule bigelovin suppresses orthotopic colorectal tumor growth and inhibits colorectal cancer metastasis via IL6/STAT3 pathway. PMID: 29454618 Ref: Src is the primary target of aripiprazole, an atypical antipsychotic drug, in its anti-tumor action. PMID: 29464048 Ref: ADAM17 is required for EGF-R-induced intestinal tumors via IL-6 trans-signaling. PMID: 29472497 Ref: alpha-Hederin inhibits interleukin 6-induced epithelial-to-mesenchymal transition associated with disruption of JAK2/STAT3 signaling in colon cancer cells. PMID: 29477470 Ref: Andrographolide presents therapeutic effect on ulcerative colitis through the inhibition of IL-23/IL-17 axis. PMID: 29511440 Ref: Downregulation of SIRT6 by miR-34c-5p is associated with poor prognosis and promotes colon cancer proliferation through inhibiting apoptosis via the JAK2/STAT3 signaling pathway. PMID: 29512698 Ref: Apigenin induces apoptosis by suppressing Bcl-xl and Mcl-1 simultaneously via signal transducer and activator of transcription 3 signaling in colon cancer. PMID: 29512707 Ref: Cardiotrophin-1 attenuates experimental colitis in mice. PMID: 29572384 Ref: Novel 1,3,4-thiadiazoles inhibit colorectal cancer via blockade of IL-6/COX-2 mediated JAK2/STAT3 signals as evidenced through data-based mathematical modeling. PMID: 29580751 Ref: Novel long noncoding RNA GACAT3 promotes colorectal cancer cell proliferation, invasion, and migration through miR-149. PMID: 29593420 Ref: Formononetin inhibits colon carcinoma cell growth and invasion by microRNA149mediated EphB3 downregulation and inhibition of PI3K/AKT and STAT3 signaling pathways. PMID: 29620230 Ref: Long non-coding RNA DILC suppresses cell proliferation and metastasis in colorectal cancer. PMID: 29621586 Ref: Long noncoding RNA BC200 regulates cell growth and invasion in colon cancer. PMID: 29625226 Ref: PARP-1 protects against colorectal tumor induction, but promotes inflammation-driven colorectal tumor progression. PMID: 29632181 Ref: Deletion of sphingosine kinase 1 inhibits liver tumorigenesis in diethylnitrosamine-treated mice. PMID: 29643998 Ref: Tea Polysaccharides Inhibit Colitis-Associated Colorectal Cancer via Interleukin-6/STAT3 Pathway. PMID: 29656647 Ref: Allicin inhibits mouse colorectal tumorigenesis through suppressing the activation of STAT3 signaling pathway. PMID: 29683343 Ref: A supercritical CO2 extract of neem leaf (A. indica) and its bioactive liminoid, nimbolide, suppresses colon cancer in preclinical models by modulating pro-inflammatory pathways. PMID: 29697164 Ref: The expression of IL10RA in colorectal cancer and its correlation with the proliferation index and the clinical stage of the disease. PMID: 29730384 Ref: Serum-derived carcinoembryonic antigen (CEA) activates fibroblasts to induce a local re-modeling of the extracellular matrix that favors the engraftment of CEA-expressing tumor cells. PMID: 29756328 Ref: M10, a novel derivative of Myricetin, prevents ulcerative colitis and colorectal tumor through attenuating robust endoplasmic reticulum stress. PMID: 29757351 Ref: Angiogenin and the MMP9-TIMP2 axis are up-regulated in proangiogenic, decidual NK-like cells from patients with colorectal cancer. PMID: 29763380 Ref: Down-regulating IL-6/GP130 targets improved the anti-tumor effects of 5-fluorouracil in colon cancer. PMID: 29777330 Ref: Pien Tze Huang ameliorates DSSinduced colonic inflammation in a mouse colitis model through inhibition of the IL6/STAT3 pathway. PMID: 29845215 Ref: Quinalizarin Induces Apoptosis through Reactive Oxygen Species (ROS)-Mediated Mitogen-Activated Protein Kinase (MAPK) and Signal Transducer and Activator of Transcription 3 (STAT3) Signaling Pathways in Colorectal Cancer Cells. PMID: 29860266 Ref: The detection and significance of cystic fibrosis transmembrane conductance regulator gene promoter mutations in Chinese patients with congenital bilateral absence of the vas deferens. PMID: 29864494 Ref: RAC1-GTP promotes epithelial-mesenchymal transition and invasion of colorectal cancer by activation of STAT3. PMID: 29884911 Ref: Novel quinazoline-based sulfonamide derivative (3D) induces apoptosis in colorectal cancer by inhibiting JAK2-STAT3 pathway. PMID: 29892198 Ref: PIAS3-mediated feedback loops promote chronic colitis-associated malignant transformation. PMID: 29896300 Ref: Macrophage migration inhibitory factor promotes resistance to MEK blockade in KRAS mutant colorectal cancer cells. PMID: 29896883 Ref: Magnolin promotes autophagy and cell cycle arrest via blocking LIF/Stat3/Mcl-1 axis in human colorectal cancers. PMID: 29899555 Ref: Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis. PMID: 29909986 Ref: STAT3 Interactors as Potential Therapeutic Targets for Cancer Treatment. PMID: 29914167 Ref: LncRNA-FEZF1-AS1 Promotes Tumor Proliferation and Metastasis in Colorectal Cancer by Regulating PKM2 Signaling. PMID: 29914894 Ref: EGFL7: Master regulator of cancer pathogenesis, angiogenesis and an emerging mediator of bone homeostasis. PMID: 29923200 Ref: STAT3/c-Myc Axis-Mediated Metabolism Alternations of Inflammation-Related Glycolysis Involve with Colorectal Carcinogenesis. PMID: 29932015 Ref: Over-expressed miRNA-200b ameliorates ulcerative colitis-related colorectal cancer in mice through orchestrating epithelial-mesenchymal transition and inflammatory responses by channel of AKT2. PMID: 29933193 Ref: STAT3 induces colorectal carcinoma progression through a novel miR-572-MOAP-1 pathway. PMID: 29942139 Ref: The Walrus and the Carpenter: Complex Regulation of Tumor Immunity in Colorectal Cancer. PMID: 29958104 Ref: Nitric oxide-donating aspirin (NO-Aspirin) suppresses lung tumorigenesis in vitro and in vivo and these effects are associated with modulation of the EGFR signaling pathway. PMID: 29982425 Ref: Silencing of Girdin suppresses the malignant behavior of colorectal carcinoma cells. PMID: 29989653 Ref: RORgammat-Expressing Tregs Drive the Growth of Colitis-Associated Colorectal Cancer by Controlling IL6 in Dendritic Cells. PMID: 29991500 Ref: Interaction of STAT3 and RelB modulates MMP-1 in colon cancer. PMID: 30040915 Ref: Annexin A2 overexpression associates with colorectal cancer invasiveness and TGF-ss induced epithelial mesenchymal transition via Src/ANXA2/STAT3. PMID: 30050103 Ref: A positive feedback loop between miR-181b and STAT3 that affects Warburg effect in colon cancer via regulating PIAS3 expression. PMID: 30054984 Ref: Cannabinoid Receptor-1 Up-regulation in Azoxymethane (AOM)-treated Mice After Dietary Treatment with Quercetin. PMID: 30061214 Ref: Activated ATF6 Induces Intestinal Dysbiosis and Innate Immune Response to Promote Colorectal Tumorigenesis. PMID: 30063920 Ref: STAT3 exacerbates survival of cancer stem-like tumorspheres in EGFR-positive colorectal cancers: RNAseq analysis and therapeutic screening. PMID: 30068339 Ref: Turmeric extract, with absorbable curcumin, has potent anti-metastatic effect in vitro and in vivo. PMID: 30097113 Ref: Combined Inactivation of TP53 and MIR34A Promotes Colorectal Cancer Development and Progression in Mice via Increasing Levels of IL6R and PAI1. PMID: 30099074 Ref: Therapeutic Ablation of Gain-of-Function Mutant p53 in Colorectal Cancer Inhibits Stat3-Mediated Tumor Growth and Invasion. PMID: 30107178 Ref: Two novel SHP-1 agonists, SC-43 and SC-78, are more potent than regorafenib in suppressing the in vitro stemness of human colorectal cancer cells. PMID: 30109144 Ref: Fusobacterium nucleatum promotes M2 polarization of macrophages in the microenvironment of colorectal tumours via a TLR4-dependent mechanism. PMID: 30121899 Ref: The tyrosine phosphorylated pro-survival form of Fas intensifies the EGF-induced signal in colorectal cancer cells through the nuclear EGFR/STAT3-mediated pathway. PMID: 30127519 Ref: Lycorine Displays Potent Antitumor Efficacy in Colon Carcinoma by Targeting STAT3. PMID: 30135654 Ref: Acetyl-11-keto-beta-boswellic acid suppresses docetaxel-resistant prostate cancer cells in vitro and in vivo by blocking Akt and Stat3 signaling, thus suppressing chemoresistant stem cell-like properties. PMID: 30171201 Ref: Myc-Associated Zinc Finger Protein Regulates the Pro-Inflammatory Response in Colitis and Colon Cancer via STAT3 Signaling. PMID: 30181395 Ref: Sorcin a Potential Molecular Target for Cancer Therapy. PMID: 30216763 Ref: PMA treated THP-1-derived-IL-6 promotes EMT of SW48 through STAT3/ERK-dependent activation of Wnt/beta-catenin signaling pathway. PMID: 30243096 Ref: Combination of resveratrol and 5-flurouracil enhanced anti-telomerase activity and apoptosis by inhibiting STAT3 and Akt signaling pathways in human colorectal cancer cells. PMID: 30250641 Ref: Upregulation of phosphorylated sphingosine kinase 1 expression in colitis-associated cancer. PMID: 30278948 Ref: Long noncoding RNA FAL1 promotes proliferation and inhibits apoptosis of human colon cancer cells. PMID: 30290064 Ref: Microcystin-LR promotes migration via the cooperation between microRNA-221/PTEN and STAT3 signal pathway in colon cancer cell line DLD-1. PMID: 30312888 Ref: Signal transducer and activator of transcription 3 inhibition enhances vemurafenib sensitivity in colon cancers harboring the BRAF(V600E) mutation. PMID: 30320916 Ref: Emodin Sensitizes Hepatocellular Carcinoma Cells to the Anti-Cancer Effect of Sorafenib through Suppression of Cholesterol Metabolism. PMID: 30321984 Ref: Correction: The ratio of STAT1 to STAT3 expression is a determinant of colorectal cancer growth. PMID: 30333916 Ref: Effects and mechanism of STAT3 silencing on the growth and apoptosis of colorectal cancer cells. PMID: 30344711 Ref: A role for paracrine interleukin-6 signaling in the tumor microenvironment in prostate tumor growth. PMID: 30345534 Ref: Targeting colon cancer with the novel STAT3 inhibitor bruceantinol. PMID: 30348989 Ref: Embelin impairs the accumulation and activation of MDSCs in colitis-associated tumorigenesis. PMID: 30377563 Ref: Resveratrol suppresses colon cancer growth by targeting the AKT/STAT3 signaling pathway. PMID: 30387805 |