Primary Site >> Liver Cancer

Gene >> STAT1

Journal: Br J Cancer. 1999 May;80(5-6):705-10.
Title: Sodium butyrate enhances STAT 1 expression in PLC/PRF/5 hepatoma cells and augments their responsiveness to interferon-alpha.
Author: Hung, W C|Chuang, L Y
PMID: 10360647
Journal: J Immunol. 2000 Oct 1;165(7):3959-65.
Title: IL-1 beta attenuates IFN-alpha beta-induced antiviral activity and STAT1 activation in the liver: involvement of proteasome-dependent pathway.
Author: Tian, Z|Shen, X|Feng, H|Gao, B
PMID: 11034404
Journal: Cancer Gene Ther. 2001 Mar;8(3):193-202.
Title: Regression of primary hepatocarcinoma in cancer-prone transgenic mice by local interferon-gamma delivery is associated with macrophages recruitment and nitric oxide production.
Author: Baratin, M|Ziol, M|Romieu, R|Kayibanda, M|Gouilleux, F|Briand, P|Leroy, P|Haddada, H|Renia, L|Viguier, M|Guillet, J G
PMID: 11332990
Journal: J Interferon Cytokine Res. 2001 Jun;21(6):399-408.
Title: Selective expression of nonsecreted interferon by an adenoviral vector confers antiproliferative and antiviral properties and causes reduction of tumor growth in nude mice.
Author: Ahmed, C M|Wills, K N|Sugarman, B J|Johnson, D E|Ramachandra, M|Nagabhushan, T L|Howe, J A
PMID: 11440637
Journal: Hepatology. 2001 Feb;33(2):346-56.
Title: Interferon-alpha delays S-phase progression in human hepatocellular carcinoma cells via inhibition of specific cyclin-dependent kinases.
Author: Murphy, D|Detjen, K M|Welzel, M|Wiedenmann, B|Rosewicz, S
PMID: 11172336
Journal: Hepatology. 2002 Nov;36(5):1115-24.
Title: Synergistic induction of apoptosis by acyclic retinoid and interferon-beta in human hepatocellular carcinoma cells.
Author: Obora, Akihiro|Shiratori, Yoshimune|Okuno, Masataka|Adachi, Seiji|Takano, Yukihiko|Matsushima-Nishiwaki, Rie|Yasuda, Ichiro|Yamada, Yasuhiro|Akita, Kuniharu|Sano, Tetsuro|Shimada, Jun|Kojima, Soichi|Okano, Yukio|Friedman, Scott L|Moriwaki, Hisataka
PMID: 12395321
Journal: J Viral Hepat. 2004 Jan;11(1):33-44.
Title: Effect of interferon alpha and cell cycle progression on translation mediated by the hepatitis C virus 5' untranslated region: a study using a transgenic mouse model.
Author: Takeda, Y|Okoshi, S|Suzuki, K|Yano, M|Gangemi, J D|Jay, G|Asakura, H|Aoyagi, Y
PMID: 14738556
Journal: Virology. 2005 Feb 5;332(1):130-44.
Title: Molecular profiling of early stage liver fibrosis in patients with chronic hepatitis C virus infection.
Author: Bieche, Ivan|Asselah, Tarik|Laurendeau, Ingrid|Vidaud, Dominique|Degot, Claude|Paradis, Valerie|Bedossa, Pierre|Valla, Dominique-Charles|Marcellin, Patrick|Vidaud, Michel
PMID: 15661146
Journal: Virol J. 2005 Dec 2;2:89.
Title: Effect of ethanol on innate antiviral pathways and HCV replication in human liver cells.
Author: Plumlee, Courtney R|Lazaro, Catherine A|Fausto, Nelson|Polyak, Stephen J
PMID: 16324217
Journal: Int J Oncol. 2007 Jan;30(1):201-8.
Title: Stronger growth-inhibitory effect of interferon (IFN)-beta compared to IFN-alpha is mediated by IFN signaling pathway in hepatocellular carcinoma cells.
Author: Damdinsuren, Bazarragchaa|Nagano, Hiroaki|Wada, Hiroshi|Kondo, Motoi|Ota, Hideo|Nakamura, Masato|Noda, Takehiro|Natsag, Javzandulam|Yamamoto, Hirofumi|Doki, Yuichiro|Umeshita, Koji|Dono, Keizo|Nakamori, Shoji|Sakon, Masato|Monden, Morito
PMID: 17143530
Journal: Gut. 2007 Jan;56(1):82-9.
Title: Beta-glucosylceramide: a novel method for enhancement of natural killer T lymphoycte plasticity in murine models of immune-mediated disorders.
Author: Zigmond, E|Preston, S|Pappo, O|Lalazar, G|Margalit, M|Shalev, Z|Zolotarov, L|Friedman, D|Alper, R|Ilan, Y
PMID: 17172586
Journal: Gastroenterology. 2007 May;132(5):1925-36.
Title: Inhibition of T-cell inflammatory cytokines, hepatocyte NF-kappaB signaling, and HCV infection by standardized Silymarin.
Author: Polyak, Stephen J|Morishima, Chihiro|Shuhart, Margaret C|Wang, Chia C|Liu, Yanze|Lee, David Y-W
PMID: 17484885
Journal: Cancer Gene Ther. 2009 May;16(5):453-61.
Title: Expression of HBX, an oncoprotein of hepatitis B virus, blocks reoviral oncolysis of hepatocellular carcinoma cells.
Author: Park, E-H|Koh, S S|Srisuttee, R|Cho, I-R|Min, H-J|Jhun, B H|Lee, Y-S|Jang, K L|Kim, C-H|Johnston, R N|Chung, Y-H
PMID: 19096445
Journal: Oncogene. 2011 Jun 9;30(23):2670-8.
Title: p53-paralog DNp73 oncogene is repressed by IFNalpha/STAT2 through the recruitment of the Ezh2 polycomb group transcriptional repressor.
Author: Testoni, B|Schinzari, V|Guerrieri, F|Gerbal-Chaloin, S|Blandino, G|Levrero, M
PMID: 21399658
Journal: Liver Int. 2011 Nov;31(10):1494-504.
Title: Clinicopathological and prognostic significance of serum and tissue Dickkopf-1 levels in human hepatocellular carcinoma.
Author: Tung, Edmund Kwok-Kwan|Mak, Carmen Ka-Man|Fatima, Sarwat|Lo, Regina Cheuk-Lam|Zhao, Heng|Zhang, Chunsheng|Dai, Hongyue|Poon, Ronnie Tung-Ping|Yuen, Man-Fung|Lai, Ching-Lung|Li, Jin-jun|Luk, John Moon-Ching|Ng, Irene Oi-Lin
PMID: 21955977
Journal: J Biol Chem. 2011 Sep 23;286(38):33369-79.
Title: Tripartite motif 24 (Trim24/Tif1alpha) tumor suppressor protein is a novel negative regulator of interferon (IFN)/signal transducers and activators of transcription (STAT) signaling pathway acting through retinoic acid receptor alpha (Raralpha) inhibition
Author: Tisserand, Johan|Khetchoumian, Konstantin|Thibault, Christelle|Dembele, Doulaye|Chambon, Pierre|Losson, Regine
PMID: 21768647
Journal: J Virol. 2012 Feb;86(3):1544-54.
Title: Activation of the Ras/Raf/MEK pathway facilitates hepatitis C virus replication via attenuation of the interferon-JAK-STAT pathway.
Author: Zhang, Qi|Gong, Rui|Qu, Jing|Zhou, Yijing|Liu, Weiyong|Chen, Mingzhou|Liu, Yingle|Zhu, Ying|Wu, Jianguo
PMID: 22114332
Journal: Int J Cancer. 2012 Dec 15;131(12):2774-84.
Title: Suppression of signal transducers and activators of transcription 1 in hepatocellular carcinoma is associated with tumor progression.
Author: Hosui, Atsushi|Klover, Peter|Tatsumi, Tomohide|Uemura, Akio|Nagano, Hiroaki|Doki, Yuichiro|Mori, Masaki|Hiramatsu, Naoki|Kanto, Tatsuya|Hennighausen, Lothar|Hayashi, Norio|Takehara, Tetsuo
PMID: 22488367
Journal: Mol Cancer. 2012 May 8;11:31.
Title: Interferon-alpha enhances antitumor activities of oncolytic adenovirus-mediated IL-24 expression in hepatocellular carcinoma.
Author: Wang, Cong-Jun|Xiao, Chao-Wen|You, Tian-Geng|Zheng, Ya-Xin|Gao, Wei|Zhou, Zhu-Qing|Chen, Jun|Xue, Xin-Bo|Fan, Jia|Zhang, Hui
PMID: 22569271
Journal: Biochem Biophys Res Commun. 2012 Jun 15;422(4):687-92.
Title: Combined anti-tumor effects of IFN-alpha and sorafenib on hepatocellular carcinoma in vitro and in vivo.
Author: Wang, Lijing|Jia, Dongwei|Duan, Fangfang|Sun, Zhichao|Liu, Xiaojuan|Zhou, Lei|Sun, Linlin|Ren, Shifang|Ruan, Yuanyuan|Gu, Jianxin
PMID: 22634008
Journal: PLoS One. 2012;7(10):e47040.
Title: Comparison of the regulation of beta-catenin signaling by type I, type II and type III interferons in hepatocellular carcinoma cells.
Author: Li, Wei|Huang, Xiaojie|Tong, Hongfei|Wang, Yuxuan|Zhang, Tong|Wang, Wen|Dai, Lili|Li, Tongzeng|Lin, Shengzhang|Wu, Hao
PMID: 23056571
Journal: Hepatology. 2013 Oct;58(4):1474-85.
Title: Invariant NKT cell activation induces neutrophil accumulation and hepatitis: opposite regulation by IL-4 and IFN-gamma.
Author: Wang, Hua|Feng, Dechun|Park, Ogyi|Yin, Shi|Gao, Bin
PMID: 23686838
Journal: Cancer Gene Ther. 2013 Jun;20(6):366-74.
Title: Aspirin enhances IFN-alpha-induced growth inhibition and apoptosis of hepatocellular carcinoma via JAK1/STAT1 pathway.
Author: Li, T|Dong, Z-R|Guo, Z-Y|Wang, C-H|Tang, Z-Y|Qu, S-F|Chen, Z-T|Li, X-W|Zhi, X-T
PMID: 23703473
Journal: Cancer Cell. 2014 Jan 13;25(1):49-63.
Title: Hepatic RIG-I predicts survival and interferon-alpha therapeutic response in hepatocellular carcinoma.
Author: Hou, Jin|Zhou, Ye|Zheng, Yuanyuan|Fan, Jia|Zhou, Weiping|Ng, Irene O L|Sun, Huichuan|Qin, Lunxiu|Qiu, Shuangjian|Lee, Joyce M F|Lo, Chung-Mau|Man, Kwan|Yang, Yuan|Yang, Yun|Yang, Yingyun|Zhang, Qian|Zhu, Xuhui|Li, Nan|Wang, Zhengxin|Ding, Guoshan|Zhuang,
PMID: 24360797
Journal: Cell Signal. 2014 Mar;26(3):619-28.
Title: Luteolin sensitizes the antiproliferative effect of interferon alpha/beta by activation of Janus kinase/signal transducer and activator of transcription pathway signaling through protein kinase A-mediated inhibition of protein tyrosine phosphatase SHP-2 i
Author: Tai, Zhengfu|Lin, Yuan|He, Yujiao|Huang, Junmei|Guo, Jiajia|Yang, Lijuan|Zhang, Guolin|Wang, Fei
PMID: 24333668
Journal: Mol Cell Biochem. 2014 Jan;385(1-2):297-307.
Title: IFN-gamma (+874) and not TNF-alpha (-308) is associated with HBV-HCC risk in India.
Author: Saxena, Roli|Chawla, Yogesh Kumar|Verma, Indu|Kaur, Jyotdeep
PMID: 24101445
Journal: J Immunol. 2014 Jan 15;192(2):691-703.
Title: IL-27, a cytokine, and IFN-lambda1, a type III IFN, are coordinated to regulate virus replication through type I IFN.
Author: Cao, Yanhua|Zhang, Rui|Zhang, Wei|Zhu, Chengliang|Yu, Yi|Song, Yu|Wang, Qing|Bai, Lan|Liu, Yingle|Wu, Kailang|Wu, Jianguo
PMID: 24337382
Journal: Int J Oncol. 2015 Apr;46(4):1710-20.
Title: RIG-I suppresses the migration and invasion of hepatocellular carcinoma cells by regulating MMP9.
Author: Liu, Zhikui|Dou, Changwei|Jia, Yuli|Li, Qing|Zheng, Xin|Yao, Yingmin|Liu, Qingguang|Song, Tao
PMID: 25626059
Journal: J Immunol. 2015 Mar 15;194(6):2757-68.
Title: Set7 facilitates hepatitis C virus replication via enzymatic activity-dependent attenuation of the IFN-related pathway.
Author: Han, Tao|Wan, Yushun|Wang, Jun|Zhao, Peng|Yuan, Yue|Wang, Li|She, Yinglong|Broering, Ruth|Lu, Mengji|Ye, Linbai|Zhu, Ying
PMID: 25681344
Journal: MBio. 2015 Feb 24;6(2):e02510.
Title: Transmitted/founder hepatitis C viruses induce cell-type- and genotype-specific differences in innate signaling within the liver.
Author: Mitchell, Angela M|Stone, Amy E L|Cheng, Linling|Ballinger, Kimberly|Edwards, Michael G|Stoddard, Mark|Li, Hui|Golden-Mason, Lucy|Shaw, George M|Khetani, Salman|Rosen, Hugo R
PMID: 25714713
Journal: Inflammation. 2015 Oct;38(5):1823-34.
Title: Potential Role of Hepatitis C Virus Alternate Reading Frame Protein in Negative Regulation of T-Bet Gene Expression.
Author: Zhu, Dan Yan|Deng, Xiao Zhao|Jiang, Long Feng|Xiao, Wen|Pei, Jia Ping|Li, Bing Jun|Wang, Chang Jun|Zhang, Jin Hai|Zhang, Qi|Zhou, Zhen Xian|Ding, Wei Liang|Xu, Xiao Dong|Yue, Ming
PMID: 25894282
Journal: Oncotarget. 2016 Jan 26;7(4):4664-79.
Title: Emodin potentiates the antiproliferative effect of interferon alpha/beta by activation of JAK/STAT pathway signaling through inhibition of the 26S proteasome.
Author: He, Yujiao|Huang, Junmei|Wang, Ping|Shen, Xiaofei|Li, Sheng|Yang, Lijuan|Liu, Wanli|Suksamrarn, Apichart|Zhang, Guolin|Wang, Fei
PMID: 26683360
Journal: J Exp Clin Cancer Res. 2016 Feb 29;35:38.
Title: CD146 promotes metastasis and predicts poor prognosis of hepatocellular carcinoma.
Author: Jiang, Guoqing|Zhang, Long|Zhu, Qin|Bai, Dousheng|Zhang, Chuanyong|Wang, Xuehao
PMID: 26928402
Journal: J Virol. 2016 May 27;90(12):5549-5560.
Title: Lipopolysaccharide and Tumor Necrosis Factor Alpha Inhibit Interferon Signaling in Hepatocytes by Increasing Ubiquitin-Like Protease 18 (USP18) Expression.
Author: MacParland, Sonya A|Ma, Xue-Zhong|Chen, Limin|Khattar, Ramzi|Cherepanov, Vera|Selzner, Markus|Feld, Jordan J|Selzner, Nazia|McGilvray, Ian D
PMID: 27009955
Journal: J Virol. 2017 Mar 29;91(8). pii: JVI.01824-16.
Title: Matrix Metalloproteinase 9 Facilitates Hepatitis B Virus Replication through Binding with Type I Interferon (IFN) Receptor 1 To Repress IFN/JAK/STAT Signaling.
Author: Chen, Junbo|Xu, Wei|Chen, Yanni|Xie, Xueping|Zhang, Yecheng|Ma, Chunqiang|Yang, Qingyu|Han, Yang|Zhu, Chengliang|Xiong, Ying|Wu, Kailang|Liu, Fang|Liu, Yingle|Wu, Jianguo
PMID: 28122987
Journal: Oncotarget. 2017 Nov 20;8(69):113734-113748.
Title: Dietary quercetin potentiates the antiproliferative effect of interferon-alpha in hepatocellular carcinoma cells through activation of JAK/STAT pathway signaling by inhibition of SHP2 phosphatase.
Author: Igbe, Ighodaro|Shen, Xiao-Fei|Jiao, Wei|Qiang, Zhe|Deng, Teng|Li, Sheng|Liu, Wan-Li|Liu, Han-Wei|Zhang, Guo-Lin|Wang, Fei
PMID: 29371942
Journal: Drug Des Devel Ther. 2017 Sep 26;11:2841-2850.
Title: Downregulation of A20 increases the cytotoxicity of IFN-gamma in hepatocellular carcinoma cells.
Author: Yin, Lei|Fang, Zheng|Shen, Ning-Jia|Qiu, Ying-He|Li, Ai-Jun|Zhang, Yong-Jie
PMID: 29033545
Journal: Toxicol Appl Pharmacol. 2017 Dec 1;336:31-39.
Title: 6-Hydroxy-3-O-methyl-kaempferol 6-O-glucopyranoside potentiates the anti-proliferative effect of interferon alpha/beta by promoting activation of the JAK/STAT signaling by inhibiting SOCS3 in hepatocellular carcinoma cells.
Author: Wonganan, Orawan|He, Yu-Jiao|Shen, Xiao-Fei|Wongkrajang, Kanjana|Suksamrarn, Apichart|Zhang, Guo-Lin|Wang, Fei
PMID: 29031523
Journal: Sci Rep. 2017 May 11;7(1):1729.
Title: Hepatitis B Virus e Antigen Activates the Suppressor of Cytokine Signaling 2 to Repress Interferon Action.
Author: Yu, Yi|Wan, Pin|Cao, Yanhua|Zhang, Wei|Chen, Junbo|Tan, Li|Wang, Yan|Sun, Zhichen|Zhang, Qi|Wan, Yushun|Zhu, Ying|Liu, Fang|Wu, Kailang|Liu, Yingle|Wu, Jianguo
PMID: 28496097
Journal: Infect Agent Cancer. 2017 Mar 20;12:17.
Title: Aflatoxin B1 inhibits the type 1 interferon response pathway via STAT1 suggesting another mechanism of hepatocellular carcinoma.
Author: Narkwa, Patrick W|Blackbourn, David J|Mutocheluh, Mohamed
PMID: 28344639
Journal: Biochim Biophys Acta Mol Cell Res. 2017 Mar;1864(3):516-526.
Title: Crosstalk between different family members: IL27 recapitulates IFNgamma responses in HCC cells, but is inhibited by IL6-type cytokines.
Author: Rolvering, Catherine|Zimmer, Andreas D|Kozar, Ines|Hermanns, Heike M|Letellier, Elisabeth|Vallar, Laurent|Nazarov, Petr V|Nicot, Nathalie|Ginolhac, Aurelien|Haan, Serge|Behrmann, Iris|Haan, Claude
PMID: 27939431
Journal: Cell Mol Immunol. 2017 Aug;14(8):712-720.
Title: miR-146a negatively regulates NK cell functions via STAT1 signaling.
Author: Xu, Dongqing|Han, Qiuju|Hou, Zhaohua|Zhang, Cai|Zhang, Jian
PMID: 26996068
Journal: Cell Mol Immunol. 2018 Mar;15(3):272-281.
Title: Type I IFN augments IL-27-dependent TRIM25 expression to inhibit HBV replication.
Author: Tan, Guangyun|Xiao, Qingfei|Song, Hongxiao|Ma, Feng|Xu, Fengchao|Peng, Di|Li, Na|Wang, Xiaosong|Niu, Junqi|Gao, Pujun|Qin, F Xiao-Feng|Cheng, Genhong
PMID: 28194021
Journal: Cancer Immunol Immunother. 2018 Feb;67(2):271-283.
Title: Cross-talk between TNF-alpha and IFN-gamma signaling in induction of B7-H1 expression in hepatocellular carcinoma cells.
Author: Li, Na|Wang, Jianing|Zhang, Na|Zhuang, Mengwei|Zong, Zhaoyun|Zou, Jiahuan|Li, Guosheng|Wang, Xiaoyan|Zhou, Huaiyu|Zhang, Lining|Shi, Yongyu
PMID: 29090321
Journal: Mol Immunol. 2018 Sep;101:203-209.
Title: MYC inhibition increases PD-L1 expression induced by IFN-gamma in hepatocellular carcinoma cells.
Author: Zou, Jiahuan|Zhuang, Mengwei|Yu, Xiaopeng|Li, Na|Mao, Rudi|Wang, Zhida|Wang, Jianing|Wang, Xiaoyan|Zhou, Huaiyu|Zhang, Lining|Shi, Yongyu
PMID: 30007230
Journal: Cytokine. 2018 Aug 17. pii: S1043-4666(18)30348-X.
Title: Interferon signaling during Hepatitis B Virus (HBV) infection and HBV-associated hepatocellular carcinoma.
Author: Mani, Saravana Kumar Kailasam|Andrisani, Ourania
PMID: 30126685
Journal: Sci Rep. 2018 Sep 3;8(1):13143.
Title: The osteopontin-CD44 axis in hepatic cancer stem cells regulates IFN signaling and HCV replication.
Author: Shirasaki, Takayoshi|Honda, Masao|Yamashita, Taro|Nio, Kouki|Shimakami, Tetsuro|Shimizu, Ryougo|Nakasyo, Saki|Murai, Kazuhisa|Shirasaki, Natsumi|Okada, Hikari|Sakai, Yoshio|Sato, Tokiharu|Suzuki, Tetsuro|Yoshioka, Katsuji|Kaneko, Shuichi
PMID: 30177680
Journal: Hepatology. 2018 Oct 17.
Title: NK cell-derived IFN-gamma promotes hepatocellular carcinoma through EpCAM-EMT axis in hepatitis B virus transgenic mice.
Author: Chen, Yongyan|Hao, Xiaolei|Sun, Rui|Wei, Haiming|Tian, Zhigang
PMID: 30329167