Primary Site >> Liver Cancer
Gene >> STAT1
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Ref: Sodium butyrate enhances STAT 1 expression in PLC/PRF/5 hepatoma cells and augments their responsiveness to interferon-alpha. PMID: 10360647 |
Ref: IL-1 beta attenuates IFN-alpha beta-induced antiviral activity and STAT1 activation in the liver: involvement of proteasome-dependent pathway. PMID: 11034404 |
Ref: Interferon-alpha delays S-phase progression in human hepatocellular carcinoma cells via inhibition of specific cyclin-dependent kinases. PMID: 11172336 Ref: Regression of primary hepatocarcinoma in cancer-prone transgenic mice by local interferon-gamma delivery is associated with macrophages recruitment and nitric oxide production. PMID: 11332990 Ref: Selective expression of nonsecreted interferon by an adenoviral vector confers antiproliferative and antiviral properties and causes reduction of tumor growth in nude mice. PMID: 11440637 |
Ref: Synergistic induction of apoptosis by acyclic retinoid and interferon-beta in human hepatocellular carcinoma cells. PMID: 12395321 |
Ref: Effect of interferon alpha and cell cycle progression on translation mediated by the hepatitis C virus 5' untranslated region: a study using a transgenic mouse model. PMID: 14738556 |
Ref: Molecular profiling of early stage liver fibrosis in patients with chronic hepatitis C virus infection. PMID: 15661146 Ref: Effect of ethanol on innate antiviral pathways and HCV replication in human liver cells. PMID: 16324217 |
Ref: Stronger growth-inhibitory effect of interferon (IFN)-beta compared to IFN-alpha is mediated by IFN signaling pathway in hepatocellular carcinoma cells. PMID: 17143530 Ref: Beta-glucosylceramide: a novel method for enhancement of natural killer T lymphoycte plasticity in murine models of immune-mediated disorders. PMID: 17172586 Ref: Inhibition of T-cell inflammatory cytokines, hepatocyte NF-kappaB signaling, and HCV infection by standardized Silymarin. PMID: 17484885 |
Ref: Expression of HBX, an oncoprotein of hepatitis B virus, blocks reoviral oncolysis of hepatocellular carcinoma cells. PMID: 19096445 |
Ref: p53-paralog DNp73 oncogene is repressed by IFNalpha/STAT2 through the recruitment of the Ezh2 polycomb group transcriptional repressor. PMID: 21399658 Ref: Tripartite motif 24 (Trim24/Tif1alpha) tumor suppressor protein is a novel negative regulator of interferon (IFN)/signal transducers and activators of transcription (STAT) signaling pathway acting through retinoic acid receptor alpha (Raralpha) inhibition PMID: 21768647 Ref: Clinicopathological and prognostic significance of serum and tissue Dickkopf-1 levels in human hepatocellular carcinoma. PMID: 21955977 |
Ref: Activation of the Ras/Raf/MEK pathway facilitates hepatitis C virus replication via attenuation of the interferon-JAK-STAT pathway. PMID: 22114332 Ref: Suppression of signal transducers and activators of transcription 1 in hepatocellular carcinoma is associated with tumor progression. PMID: 22488367 Ref: Interferon-alpha enhances antitumor activities of oncolytic adenovirus-mediated IL-24 expression in hepatocellular carcinoma. PMID: 22569271 Ref: Combined anti-tumor effects of IFN-alpha and sorafenib on hepatocellular carcinoma in vitro and in vivo. PMID: 22634008 Ref: Comparison of the regulation of beta-catenin signaling by type I, type II and type III interferons in hepatocellular carcinoma cells. PMID: 23056571 |
Ref: Invariant NKT cell activation induces neutrophil accumulation and hepatitis: opposite regulation by IL-4 and IFN-gamma. PMID: 23686838 Ref: Aspirin enhances IFN-alpha-induced growth inhibition and apoptosis of hepatocellular carcinoma via JAK1/STAT1 pathway. PMID: 23703473 |
Ref: IFN-gamma (+874) and not TNF-alpha (-308) is associated with HBV-HCC risk in India. PMID: 24101445 Ref: Luteolin sensitizes the antiproliferative effect of interferon alpha/beta by activation of Janus kinase/signal transducer and activator of transcription pathway signaling through protein kinase A-mediated inhibition of protein tyrosine phosphatase SHP-2 i PMID: 24333668 Ref: IL-27, a cytokine, and IFN-lambda1, a type III IFN, are coordinated to regulate virus replication through type I IFN. PMID: 24337382 Ref: Hepatic RIG-I predicts survival and interferon-alpha therapeutic response in hepatocellular carcinoma. PMID: 24360797 |
Ref: RIG-I suppresses the migration and invasion of hepatocellular carcinoma cells by regulating MMP9. PMID: 25626059 Ref: Set7 facilitates hepatitis C virus replication via enzymatic activity-dependent attenuation of the IFN-related pathway. PMID: 25681344 Ref: Transmitted/founder hepatitis C viruses induce cell-type- and genotype-specific differences in innate signaling within the liver. PMID: 25714713 Ref: Potential Role of Hepatitis C Virus Alternate Reading Frame Protein in Negative Regulation of T-Bet Gene Expression. PMID: 25894282 |
Ref: Emodin potentiates the antiproliferative effect of interferon alpha/beta by activation of JAK/STAT pathway signaling through inhibition of the 26S proteasome. PMID: 26683360 Ref: CD146 promotes metastasis and predicts poor prognosis of hepatocellular carcinoma. PMID: 26928402 Ref: Lipopolysaccharide and Tumor Necrosis Factor Alpha Inhibit Interferon Signaling in Hepatocytes by Increasing Ubiquitin-Like Protease 18 (USP18) Expression. PMID: 27009955 |
Ref: miR-146a negatively regulates NK cell functions via STAT1 signaling. PMID: 26996068 Ref: Crosstalk between different family members: IL27 recapitulates IFNgamma responses in HCC cells, but is inhibited by IL6-type cytokines. PMID: 27939431 Ref: Matrix Metalloproteinase 9 Facilitates Hepatitis B Virus Replication through Binding with Type I Interferon (IFN) Receptor 1 To Repress IFN/JAK/STAT Signaling. PMID: 28122987 Ref: Aflatoxin B1 inhibits the type 1 interferon response pathway via STAT1 suggesting another mechanism of hepatocellular carcinoma. PMID: 28344639 Ref: Hepatitis B Virus e Antigen Activates the Suppressor of Cytokine Signaling 2 to Repress Interferon Action. PMID: 28496097 Ref: 6-Hydroxy-3-O-methyl-kaempferol 6-O-glucopyranoside potentiates the anti-proliferative effect of interferon alpha/beta by promoting activation of the JAK/STAT signaling by inhibiting SOCS3 in hepatocellular carcinoma cells. PMID: 29031523 Ref: Downregulation of A20 increases the cytotoxicity of IFN-gamma in hepatocellular carcinoma cells. PMID: 29033545 Ref: Dietary quercetin potentiates the antiproliferative effect of interferon-alpha in hepatocellular carcinoma cells through activation of JAK/STAT pathway signaling by inhibition of SHP2 phosphatase. PMID: 29371942 |
Ref: Type I IFN augments IL-27-dependent TRIM25 expression to inhibit HBV replication. PMID: 28194021 Ref: Cross-talk between TNF-alpha and IFN-gamma signaling in induction of B7-H1 expression in hepatocellular carcinoma cells. PMID: 29090321 Ref: MYC inhibition increases PD-L1 expression induced by IFN-gamma in hepatocellular carcinoma cells. PMID: 30007230 Ref: Interferon signaling during Hepatitis B Virus (HBV) infection and HBV-associated hepatocellular carcinoma. PMID: 30126685 Ref: The osteopontin-CD44 axis in hepatic cancer stem cells regulates IFN signaling and HCV replication. PMID: 30177680 Ref: NK cell-derived IFN-gamma promotes hepatocellular carcinoma through EpCAM-EMT axis in hepatitis B virus transgenic mice. PMID: 30329167 |