Primary Site >> Colorectal Cancer

Gene >> SPHK2

Journal: Cancer Res. 2007 Nov 1;67(21):10466-74.
Title: Involvement of sphingosine kinase 2 in p53-independent induction of p21 by the chemotherapeutic drug doxorubicin.
Author: Sankala, Heidi M|Hait, Nitai C|Paugh, Steven W|Shida, Dai|Lepine, Sandrine|Elmore, Lynne W|Dent, Paul|Milstien, Sheldon|Spiegel, Sarah
PMID: 17974990
Journal: Cancer Res. 2008 Aug 15;68(16):6569-77.
Title: Cross-talk between LPA1 and epidermal growth factor receptors mediates up-regulation of sphingosine kinase 1 to promote gastric cancer cell motility and invasion.
Author: Shida, Dai|Fang, Xianjun|Kordula, Tomasz|Takabe, Kazuaki|Lepine, Sandrine|Alvarez, Sergio E|Milstien, Sheldon|Spiegel, Sarah
PMID: 18701480
Journal: J Biol Chem. 2009 Apr 17;284(16):10422-32.
Title: Sphingosine kinase isoforms regulate oxaliplatin sensitivity of human colon cancer cells through ceramide accumulation and Akt activation.
Author: Nemoto, Satoshi|Nakamura, Mitsuhiro|Osawa, Yosuke|Kono, Saki|Itoh, Yoshinori|Okano, Yukio|Murate, Takashi|Hara, Akira|Ueda, Hiroshi|Nozawa, Yoshinori|Banno, Yoshiko
PMID: 19240026
Journal: Exp Cell Res. 2012 Jan 1;318(1):43-52.
Title: Sensitization of human colon cancer cells to sodium butyrate-induced apoptosis by modulation of sphingosine kinase 2 and protein kinase D.
Author: Xiao, Min|Liu, Yungang|Zou, Fei
PMID: 22024383
Journal: Cancer Lett. 2012 Jun 28;319(2):182-189.
Title: Sphingosine 1-phosphate antagonizes the effect of all-trans retinoic acid (ATRA) in a human colon cancer cell line by modulation of RARbeta expression.
Author: Sun, De-Fu|Gao, Zu-Hua|Liu, Hui-Ping|Yuan, Yi|Qu, Xian-Jun
PMID: 22261335
Journal: Cancer Cell. 2013 Jan 14;23(1):107-20.
Title: Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer.
Author: Liang, Jie|Nagahashi, Masayuki|Kim, Eugene Y|Harikumar, Kuzhuvelil B|Yamada, Akimitsu|Huang, Wei-Ching|Hait, Nitai C|Allegood, Jeremy C|Price, Megan M|Avni, Dorit|Takabe, Kazuaki|Kordula, Tomasz|Milstien, Sheldon|Spiegel, Sarah
PMID: 23273921
Journal: World J Gastroenterol. 2014 Aug 14;20(30):10279-87.
Title: STAT3 and sphingosine-1-phosphate in inflammation-associated colorectal cancer.
Author: Nguyen, Andrew V|Wu, Yuan-Yuan|Lin, Elaine Y
PMID: 25132744
Journal: Biomed Pharmacother. 2014 Oct;68(8):1089-97.
Title: Down-regulation of sphingosine kinase 2 (SphK2) increases the effects of all-trans-retinoic acid (ATRA) on colon cancer cells.
Author: Chu, Jia-Hui|Gao, Zu-Hua|Qu, Xian-Jun
PMID: 25455157
Journal: Clin Exp Gastroenterol. 2014 Jun 30;7:205-14.
Title: S1pping fire: Sphingosine-1-phosphate signaling as an emerging target in inflammatory bowel disease and colitis-associated cancer.
Author: Degagne, Emilie|Saba, Julie D
PMID: 25061328
Journal: Biomed Environ Sci. 2014 Mar;27(3):197-203.
Title: Sodium butyrate induces apoptosis of human colon cancer cells by modulating ERK and sphingosine kinase 2.
Author: Xiao, Min|Liu, Yun Gang|Zou, Meng Chen|Zou, Fei
PMID: 24709100
Journal: J Cell Biochem. 2015 Oct;116(10):2227-38.
Title: Increased SPHK2 Transcription of Human Colon Cancer Cells in Serum-Depleted Culture: The Involvement of CREB Transcription Factor.
Author: Mizutani, Naoki|Omori, Yukari|Tanaka, Koji|Ito, Hiromi|Takagi, Akira|Kojima, Tetsuhito|Nakatochi, Masahiro|Ogiso, Hideo|Kawamoto, Yoshiyuki|Nakamura, Mitsuhiro|Suzuki, Motoshi|Kyogashima, Mamoru|Tamiya-Koizumi, Keiko|Nozawa, Yoshinori|Murate, Takashi
PMID: 25808826
Journal: J Exp Clin Cancer Res. 2015 Sep 4;34:94.
Title: Targeting sphingosine kinase 2 (SphK2) by ABC294640 inhibits colorectal cancer cell growth in vitro and in vivo.
Author: Xun, Cai|Chen, Min-Bin|Qi, Li|Tie-Ning, Zhang|Peng, Xue|Ning, Li|Zhi-Xiao, Chen|Li-Wei, Wang
PMID: 26337959
Journal: Tumour Biol. 2016 Jun;37(6):8455-60.
Title: Sphingosine kinase 2 promotes colorectal cancer cell proliferation and invasion by enhancing MYC expression.
Author: Zhang, Lan|Liu, Xuezheng|Zuo, Zhongfu|Hao, Chunyan|Ma, Yanmei
PMID: 26733171
Journal: Oncotarget. 2017 Jun 13;8(24):39605-39617.
Title: Overexpression of SphK2 contributes to ATRA resistance in colon cancer through rapid degradation of cytoplasmic RXRalpha by K48/K63-linked polyubiquitination.
Author: Shi, Wen-Na|Cui, Shu-Xiang|Song, Zhi-Yu|Wang, Shu-Qing|Sun, Shi-Yue|Yu, Xin-Feng|Li, Ye|Zhang, Yu-Hang|Gao, Zu-Hua|Qu, Xian-Jun
PMID: 28465486
Journal: Biomed Pharmacother. 2018 Sep;105:922-931.
Title: MiR-363-3p suppresses tumor growth and metastasis of colorectal cancer via targeting SphK2.
Author: Dong, Jinlang|Geng, Jianshan|Tan, Weiwei
PMID: 30021386
Journal: Chem Phys Lipids. 2018 Sep;215:29-33.
Title: Synthesis of dansyl labeled sphingosine kinase 1 inhibitor.
Author: Park, Eun-Young|Lee, Taeho|Oh, Yoon Sin|Lee, Joo-Youn|Shrestha, Jitendra|Hong, Seung Woo|Jin, Yun Ji|Jo, GeunHyung|Kim, Sanghee|Hwang, Gil Tae|Han, Dong-Sul|Baek, Dong Jae
PMID: 30044952
Journal: Mol Cancer Res. 2018 Aug 28. pii: 1541-7786.MCR-18-0199.
Title: De Novo Fatty Acid Synthesis Driven Sphingolipid Metabolism Promotes Metastatic Potential of Colorectal Cancer.
Author: Jafari, Naser|Drury, James|Morris, Andrew J|Onono, Fredrick O|Stevens, Payton D|Gao, Tianyan|Liu, Jinpeng|Wang, Chi|Lee, Eun Y|Weiss, Heidi L|Evers, B Mark|Zaytseva, Yekaterina Y
PMID: 30154249