Primary Site >> Colorectal Cancer
Gene >> SPHK2
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Ref: Involvement of sphingosine kinase 2 in p53-independent induction of p21 by the chemotherapeutic drug doxorubicin. PMID: 17974990 |
Ref: Cross-talk between LPA1 and epidermal growth factor receptors mediates up-regulation of sphingosine kinase 1 to promote gastric cancer cell motility and invasion. PMID: 18701480 |
Ref: Sphingosine kinase isoforms regulate oxaliplatin sensitivity of human colon cancer cells through ceramide accumulation and Akt activation. PMID: 19240026 |
Ref: Sensitization of human colon cancer cells to sodium butyrate-induced apoptosis by modulation of sphingosine kinase 2 and protein kinase D. PMID: 22024383 Ref: Sphingosine 1-phosphate antagonizes the effect of all-trans retinoic acid (ATRA) in a human colon cancer cell line by modulation of RARbeta expression. PMID: 22261335 |
Ref: Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer. PMID: 23273921 |
Ref: Sodium butyrate induces apoptosis of human colon cancer cells by modulating ERK and sphingosine kinase 2. PMID: 24709100 Ref: S1pping fire: Sphingosine-1-phosphate signaling as an emerging target in inflammatory bowel disease and colitis-associated cancer. PMID: 25061328 Ref: STAT3 and sphingosine-1-phosphate in inflammation-associated colorectal cancer. PMID: 25132744 Ref: Down-regulation of sphingosine kinase 2 (SphK2) increases the effects of all-trans-retinoic acid (ATRA) on colon cancer cells. PMID: 25455157 |
Ref: Increased SPHK2 Transcription of Human Colon Cancer Cells in Serum-Depleted Culture: The Involvement of CREB Transcription Factor. PMID: 25808826 Ref: Targeting sphingosine kinase 2 (SphK2) by ABC294640 inhibits colorectal cancer cell growth in vitro and in vivo. PMID: 26337959 |
Ref: Sphingosine kinase 2 promotes colorectal cancer cell proliferation and invasion by enhancing MYC expression. PMID: 26733171 |
Ref: Overexpression of SphK2 contributes to ATRA resistance in colon cancer through rapid degradation of cytoplasmic RXRalpha by K48/K63-linked polyubiquitination. PMID: 28465486 |
Ref: MiR-363-3p suppresses tumor growth and metastasis of colorectal cancer via targeting SphK2. PMID: 30021386 Ref: Synthesis of dansyl labeled sphingosine kinase 1 inhibitor. PMID: 30044952 Ref: De Novo Fatty Acid Synthesis Driven Sphingolipid Metabolism Promotes Metastatic Potential of Colorectal Cancer. PMID: 30154249 |