Primary Site >> Colorectal Cancer

Gene >> SP3

Journal: Eur J Biochem. 1998 May 1;253(3):778-86.
Title: Transcriptional regulation of the non-specific cross-reacting antigen gene, a member of the carcinoembryonic antigen gene family up-regulated in colorectal carcinomas.
Author: Koops, M D|Thompson, J|Zimmermann, W|Stanners, C P
PMID: 9654079
Journal: J Biol Chem. 2001 Feb 2;276(5):3348-52.
Title: Sp3 is a transcriptional repressor of transforming growth factor-beta receptors.
Author: Ammanamanchi, S|Brattain, M G
PMID: 11027677
Journal: Cancer Res. 2001 Jan 15;61(2):570-6.
Title: The Sp family of transcription factors in the regulation of the human and mouse MUC2 gene promoters.
Author: Aslam, F|Palumbo, L|Augenlicht, L H|Velcich, A
PMID: 11212251
Journal: J Biol Chem. 2001 Aug 31;276(35):32854-9.
Title: 5-azaC treatment enhances expression of transforming growth factor-beta receptors through down-regulation of Sp3.
Author: Ammanamanchi, S|Brattain, M G
PMID: 11443124
Journal: Anticancer Res. 2002 Nov-Dec;22(6B):3545-54.
Title: Altered expression of the receptor and ligand in the TGF beta signaling pathway in diffusely infiltrating colon carcinoma.
Author: Nagayama, Satoshi|Onodera, Hisashi|Toguchida, Junya|Imamura, Masayuki
PMID: 12552954
Journal: Nucleic Acids Res. 2003 Mar 15;31(6):1693-703.
Title: Histone deacetylase inhibitors stimulate mitochondrial HMG-CoA synthase gene expression via a promoter proximal Sp1 site.
Author: Camarero, Nuria|Nadal, Alicia|Barrero, Maria Jose|Haro, Diego|Marrero, Pedro F
PMID: 12626711
Journal: Oncogene. 2004 Apr 1;23(14):2454-64.
Title: Identification of a novel SP3 binding site in the promoter of human IGFBP4 gene: role of SP3 and AP-1 in regulating promoter activity in CaCo2 cells.
Author: Shen, Quiang|Singh, Pomila
PMID: 14767471
Journal: Oncogene. 2004 Jul 8;23(31):5340-9.
Title: Histone deacetylase inhibitors activate INK4d gene through Sp1 site in its promoter.
Author: Yokota, Tomoya|Matsuzaki, Youichirou|Miyazawa, Kazuhiro|Zindy, Frederique|Roussel, Martine F|Sakai, Toshiyuki
PMID: 15107822
Journal: Mol Pharmacol. 2005 Aug;68(2):317-29. Epub 2005 May 9.
Title: Cyclooxygenase-2 inhibitors decrease vascular endothelial growth factor expression in colon cancer cells by enhanced degradation of Sp1 and Sp4 proteins.
Author: Abdelrahim, Maen|Safe, Stephen
PMID: 15883203
Journal: Oncol Res. 2005;15(5):265-79.
Title: A bisanthracycline (WP631) represses uPAR gene expression and cell migration of RKO colon cancer cells by interfering with transcription factor binding to a chromatin-accessible -148/-124 promoter region.
Author: Nair, Rajesh R|Wang, Heng|Jamaluddin, M S|Fokt, Izabella|Priebe, Waldemar|Boyd, Douglas D
PMID: 16261846
Journal: J Biol Chem. 2006 May 12;281(19):13548-58. Epub 2006 Mar 13.
Title: Histone deacetylase 3 (HDAC3) and other class I HDACs regulate colon cell maturation and p21 expression and are deregulated in human colon cancer.
Author: Wilson, Andrew J|Byun, Do-Sun|Popova, Natalia|Murray, Lucas B|L'Italien, Kaitlin|Sowa, Yoshihiro|Arango, Diego|Velcich, Anna|Augenlicht, Leonard H|Mariadason, John M
PMID: 16533812
Journal: Oncogene. 2007 Jul 5;26(31):4550-62.
Title: Tumor suppressor Pdcd4 inhibits invasion/intravasation and regulates urokinase receptor (u-PAR) gene expression via Sp-transcription factors.
Author: Leupold, J H|Yang, H-S|Colburn, N H|Asangani, I|Post, S|Allgayer, H
PMID: 17297470
Journal: Eur J Cancer. 2007 Nov;43(16):2404-12. Epub 2007 Aug 30.
Title: Green tea catechin (-)-epicatechin gallate induces tumour suppressor protein ATF3 via EGR-1 activation.
Author: Cho, Kyou-Nam|Sukhthankar, Mugdha|Lee, Seong-Ho|Yoon, Joo-Heon|Baek, Seung Joon
PMID: 17764926
Journal: Cancer Res. 2007 Apr 1;67(7):3286-94.
Title: Regulation of vascular endothelial growth factor receptor-1 expression by specificity proteins 1, 3, and 4 in pancreatic cancer cells.
Author: Abdelrahim, Maen|Baker, Cheryl H|Abbruzzese, James L|Sheikh-Hamad, David|Liu, Shengxi|Cho, Sung Dae|Yoon, Kyungsil|Safe, Stephen
PMID: 17409437
Journal: Clin Cancer Res. 2007 Feb 15;13(4):1123-32.
Title: Analysis of specific transcriptional regulators as early predictors of independent prognostic relevance in resected colorectal cancer.
Author: Maurer, Gabriele D|Leupold, Joerg H|Schewe, Denis M|Biller, Tobias|Kates, Ronald E|Hornung, Hans-Martin|Lau-Werner, Ulla|Post, Stefan|Allgayer, Heike
PMID: 17317820
Journal: Biochem Pharmacol. 2008 Jan 15;75(2):414-26. Epub 2007 Sep 8.
Title: Transcriptional regulation of aldo-keto reductase 1C1 in HT29 human colon cancer cells resistant to methotrexate: role in the cell cycle and apoptosis.
Author: Selga, Elisabet|Noe, Veronique|Ciudad, Carlos J
PMID: 17945194
Journal: Carcinogenesis. 2008 Sep;29(9):1816-24.
Title: Allyl mercaptan, a garlic-derived organosulfur compound, inhibits histone deacetylase and enhances Sp3 binding on the P21WAF1 promoter.
Author: Nian, Hui|Delage, Barbara|Pinto, John T|Dashwood, Roderick H
PMID: 18628250
Journal: Environ Mol Mutagen. 2009 Apr;50(3):213-21.
Title: Modulation of histone deacetylase activity by dietary isothiocyanates and allyl sulfides: studies with sulforaphane and garlic organosulfur compounds.
Author: Nian, Hui|Delage, Barbara|Ho, Emily|Dashwood, Roderick H
PMID: 19197985
Journal: Int J Cancer. 2009 Oct 15;125(8):1965-74.
Title: Oncogenic microRNA-27a is a target for anticancer agent methyl 2-cyano-3,11-dioxo-18beta-olean-1,12-dien-30-oate in colon cancer cells.
Author: Chintharlapalli, Sudhakar|Papineni, Sabitha|Abdelrahim, Maen|Abudayyeh, Ala|Jutooru, Indira|Chadalapaka, Gayathri|Wu, Fei|Mertens-Talcott, Susanne|Vanderlaag, Kathy|Cho, Sung Dae|Smith, Roger 3rd|Safe, Stephen
PMID: 19582879
Journal: Nagoya J Med Sci. 2009 Sep;71(3-4):127-36.
Title: Mutated ras induced PLD1 gene expression through increased Sp1 transcription factor.
Author: Gao, Siqiang|Murakami, Masashi|Ito, Hiromi|Furuhata, Ayako|Yoshida, Kayo|Tagawa, Yoko|Hagiwara, Kazumi|Takagi, Akira|Kojima, Tetsuhito|Suzuki, Motoshi|Banno, Yoshiko|Nozawa, Yoshinori|Murate, Takashi
PMID: 19994725
Journal: J Biol Inorg Chem. 2010 Sep;15(7):1157-69.
Title: Antiproliferative Pt(IV) complexes: synthesis, biological activity, and quantitative structure-activity relationship modeling.
Author: Gramatica, Paola|Papa, Ester|Luini, Mara|Monti, Elena|Gariboldi, Marzia B|Ravera, Mauro|Gabano, Elisabetta|Gaviglio, Luca|Osella, Domenico
PMID: 20526854
Journal: BioDrugs. 2010 Apr 1;24(2):131-46.
Title: Selective suicide gene therapy of colon cancer exploiting the urokinase plasminogen activator receptor promoter.
Author: Teimoori-Toolabi, Ladan|Azadmanesh, Kayhan|Amanzadeh, Amir|Zeinali, Sirous
PMID: 20199127
Journal: Crit Rev Oncol Hematol. 2010 Mar;73(3):185-91.
Title: Pdcd4, a colon cancer prognostic that is regulated by a microRNA.
Author: Allgayer, Heike
PMID: 19836969
Journal: Cancer Res. 2010 Jan 15;70(2):609-20.
Title: Apoptotic sensitivity of colon cancer cells to histone deacetylase inhibitors is mediated by an Sp1/Sp3-activated transcriptional program involving immediate-early gene induction.
Author: Wilson, Andrew J|Chueh, Anderly C|Togel, Lars|Corner, Georgia A|Ahmed, Naseem|Goel, Sanjay|Byun, Do-Sun|Nasser, Shannon|Houston, Michele A|Jhawer, Minaxi|Smartt, Helena J M|Murray, Lucas B|Nicholas, Courtney|Heerdt, Barbara G|Arango, Diego|Augenlicht, Leo
PMID: 20068171
Journal: Mol Cancer Res. 2011 Feb;9(2):195-202.
Title: GT-094, a NO-NSAID, inhibits colon cancer cell growth by activation of a reactive oxygen species-microRNA-27a: ZBTB10-specificity protein pathway.
Author: Pathi, Satya S|Jutooru, Indira|Chadalapaka, Gayathri|Sreevalsan, Sandeep|Anand, S|Thatcher, Gregory Rj|Safe, Stephen
PMID: 21156786
Journal: BMC Cancer. 2011 Aug 24;11:371.
Title: Betulinic acid inhibits colon cancer cell and tumor growth and induces proteasome-dependent and -independent downregulation of specificity proteins (Sp) transcription factors.
Author: Chintharlapalli, Sudhakar|Papineni, Sabitha|Lei, Ping|Pathi, Satya|Safe, Stephen
PMID: 21864401
Journal: Nutr Cancer. 2011;63(7):1133-42.
Title: Pharmacologic doses of ascorbic acid repress specificity protein (Sp) transcription factors and Sp-regulated genes in colon cancer cells.
Author: Pathi, Satya S|Lei, Ping|Sreevalsan, Sandeep|Chadalapaka, Gayathri|Jutooru, Indira|Safe, Stephen
PMID: 21919647
Journal: PLoS One. 2012;7(10):e48208.
Title: Aspirin inhibits colon cancer cell and tumor growth and downregulates specificity protein (Sp) transcription factors.
Author: Pathi, Satya|Jutooru, Indira|Chadalapaka, Gayathri|Nair, Vijayalekshmi|Lee, Syng-Ook|Safe, Stephen
PMID: 23110215
Journal: PLoS One. 2012;7(10):e48189.
Title: Transcriptional control of the multi-drug transporter ABCB1 by transcription factor Sp3 in different human tissues.
Author: Gromnicova, Radka|Romero, Ignacio|Male, David
PMID: 23133566
Journal: BMC Cancer. 2012 Nov 30;12:564.
Title: Curcumin and synthetic analogs induce reactive oxygen species and decreases specificity protein (Sp) transcription factors by targeting microRNAs.
Author: Gandhy, Shruti U|Kim, Kyounghyun|Larsen, Lesley|Rosengren, Rhonda J|Safe, Stephen
PMID: 23194063
Journal: Curr Colorectal Cancer Rep. 2013 Dec;9(4):350-357.
Title: REACTIVE OXYGEN SPECIES AND COLORECTAL CANCER.
Author: Sreevalsan, Sandeep|Safe, Stephen
PMID: 25584043
Journal: Mol Cancer Ther. 2013 Nov;12(11):2483-93.
Title: The cannabinoid WIN 55,212-2 decreases specificity protein transcription factors and the oncogenic cap protein eIF4E in colon cancer cells.
Author: Sreevalsan, Sandeep|Safe, Stephen
PMID: 24030632
Journal: Gan To Kagaku Ryoho. 2013 Jul;40(7):951-4.
Title: [Successful treatment of a patient using mFOLFOX6 after laparoscopic surgery for rectal cancer with peritoneal dissemination].
Author: Hamano, Genya|Ikebe, Takashi|Mayumi, Katsuyuki|Takemura, Masashi|Hori, Takaaki|Nishioka, Takayoshi
PMID: 23863744
Journal: Nutr Cancer. 2013;65(3):494-504.
Title: Resveratrol and quercetin in combination have anticancer activity in colon cancer cells and repress oncogenic microRNA-27a.
Author: Del Follo-Martinez, Armando|Banerjee, Nivedita|Li, Xiangrong|Safe, Stephen|Mertens-Talcott, Susanne
PMID: 23530649
Journal: Mol Nutr Food Res. 2013 Sep;57(9):1638-48.
Title: The drug resistance suppression induced by curcuminoids in colon cancer SW-480 cells is mediated by reactive oxygen species-induced disruption of the microRNA-27a-ZBTB10-Sp axis.
Author: Noratto, Giuliana D|Jutooru, Indira|Safe, Stephen|Angel-Morales, Gabriela|Mertens-Talcott, Susanne U
PMID: 23471840
Journal: Mol Carcinog. 2014 Feb;53 Suppl 1:E53-61.
Title: Tolfenamic acid inhibits colon cancer cell and tumor growth and induces degradation of specificity protein (Sp) transcription factors.
Author: Pathi, Satya|Li, Xi|Safe, Stephen
PMID: 23670891
Journal: Oncol Rep. 2014 Jan;31(1):117-24.
Title: Combination of quercetin and hyperoside has anticancer effects on renal cancer cells through inhibition of oncogenic microRNA-27a.
Author: Li, Wei|Liu, Min|Xu, Yun-Fei|Feng, Yuan|Che, Jian-Ping|Wang, Guang-Chun|Zheng, Jun-Hua
PMID: 24173369
Journal: FASEB J. 2014 Oct;28(10):4265-79.
Title: Overexpression of histone deacetylases in cancer cells is controlled by interplay of transcription factors and epigenetic modulators.
Author: Yang, Hui|Salz, Tal|Zajac-Kaye, Maria|Liao, Daiqing|Huang, Suming|Qiu, Yi
PMID: 24948597
Journal: Int J Clin Exp Pathol. 2014 Jun 15;7(7):4454-60. eCollection 2014.
Title: Immunohistochemical results of HER2/neu protein expression assessed by rabbit monoclonal antibodies SP3 and 4B5 in colorectal carcinomas.
Author: Song, Zhangjuan|Deng, Yan|Zhuang, Kangmin|Li, Aimin|Liu, Side
PMID: 25120833
Journal: Cell Death Dis. 2014 Oct 16;5:e1476.
Title: HDAC8 and STAT3 repress BMF gene activity in colon cancer cells.
Author: Kang, Y|Nian, H|Rajendran, P|Kim, E|Dashwood, W M|Pinto, J T|Boardman, L A|Thibodeau, S N|Limburg, P J|Lohr, C V|Bisson, W H|Williams, D E|Ho, E|Dashwood, R H
PMID: 25321483
Journal: BMC Cancer. 2015 Dec 16;15:974.
Title: Sulindac sulfide inhibits colon cancer cell growth and downregulates specificity protein transcription factors.
Author: Li, Xi|Pathi, Satya S|Safe, Stephen
PMID: 26673922
Journal: PLoS One. 2016 Jan 25;11(1):e0147886.
Title: Sp1 and Sp3 Are the Transcription Activators of Human ek1 Promoter in TSA-Treated Human Colon Carcinoma Cells.
Author: Kuan, Chee Sian|See Too, Wei Cun|Few, Ling Ling
PMID: 26807725
Journal: Oncotarget. 2016 Apr 19;7(16):22245-56.
Title: Specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 are non-oncogene addiction genes in cancer cells.
Author: Hedrick, Erik|Cheng, Yating|Jin, Un-Ho|Kim, Kyounghyun|Safe, Stephen
PMID: 26967243
Journal: Mol Carcinog. 2017 Feb;56(2):735-750.
Title: Induction of cell differentiation activates transcription of the Sarco/Endoplasmic Reticulum calcium-ATPase 3 gene (ATP2A3) in gastric and colon cancer cells.
Author: Flores-Peredo, Lucia|Rodriguez, Gabriela|Zarain-Herzberg, Angel
PMID: 27433831
Journal: Int J Oncol. 2018 Aug;53(2):567-578.
Title: E2F1/SP3/STAT6 axis is required for IL-4-induced epithelial-mesenchymal transition of colorectal cancer cells.
Author: Chen, Jiaoe|Gong, Chaoju|Mao, Huiqin|Li, Zhaoyun|Fang, Zejun|Chen, Qiang|Lin, Min|Jiang, Xiang|Hu, Yanyan|Wang, Wei|Zhang, Xiaomin|Chen, Xianjun|Li, Hongzhang
PMID: 29901191
Journal: Mol Pharmacol. 2018 Oct;94(4):1187-1196.
Title: Bortezomib Targets Sp Transcription Factors in Cancer Cells.
Author: Karki, Keshav|Harishchandra, Sneha|Safe, Stephen
PMID: 30115673