Primary Site >> Colorectal Cancer

Gene >> SP1

Journal: Lancet. 1978 Mar 18;1(8064):579-81.
Title: Serum-SP1-pregnancy-specific-beta-glycoprotein in choriocarcinoma and other neoplastic disease.
Author: Searle, F|Leake, B A|Bagshawe, K D|Dent, J
PMID: 76123
Journal: Cancer. 1981 Mar 15;47(6):1241-5.
Title: Tumor-associated antigens in polyps and carcinoma of the human large bowel.
Author: Skinner, J M|Whitehead, R
PMID: 6164469
Journal: Cancer Res. 1991 Feb 15;51(4):1185-9.
Title: Reduced tumorigenicity of murine tumor cells secreting gamma-interferon is due to nonspecific host responses and is unrelated to class I major histocompatibility complex expression.
Author: Esumi, N|Hunt, B|Itaya, T|Frost, P
PMID: 1900037
Journal: Cancer Res. 1995 Sep 1;55(17):3873-82.
Title: In vitro and in vivo footprint analysis of the promoter of carcinoembryonic antigen in colon carcinoma cells: effects of interferon gamma treatment.
Author: Chen, C J|Li, L J|Maruya, A|Shively, J E
PMID: 7641207
Journal: Carcinogenesis. 1996 Mar;17(3):427-33.
Title: Induction of the transcription factor AP-1 in cultured human colon adenocarcinoma cells following exposure to bile acids.
Author: Hirano, F|Tanada, H|Makino, Y|Okamoto, K|Hiramoto, M|Handa, H|Makino, I
PMID: 8631127
Journal: Dis Colon Rectum. 1996 Apr;39(4):406-9.
Title: Androgen induces ornithine decarboxylase gene expression in colonic cell line HT-29.
Author: Cintron, J R|Asadi, F K|Malakouti, S|Abcarian, H A
PMID: 8878500
Journal: Br J Cancer. 1997;76(9):1124-30.
Title: Hypermethylation of the WT1 and calcitonin gene promoter regions at chromosome 11p in human colorectal cancer.
Author: Hiltunen, M O|Koistinaho, J|Alhonen, L|Myohanen, S|Marin, S|Kosma, V M|Paakkonen, M|Janne, J
PMID: 9365158
Journal: J Biol Chem. 1998 Jan 30;273(5):3060-7.
Title: Identification of a goblet cell-specific enhancer element in the rat intestinal trefoil factor gene promoter bound by a goblet cell nuclear protein.
Author: Ogata, H|Inoue, N|Podolsky, D K
PMID: 9446622
Journal: J Biol Chem. 1998 Feb 6;273(6):3611-7.
Title: Modulation of O-linked N-acetylglucosamine levels on nuclear and cytoplasmic proteins in vivo using the peptide O-GlcNAc-beta-N-acetylglucosaminidase inhibitor O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino-N-phenylcarbamate.
Author: Haltiwanger, R S|Grove, K|Philipsberg, G A
PMID: 9452489
Journal: Eur J Biochem. 1998 May 1;253(3):778-86.
Title: Transcriptional regulation of the non-specific cross-reacting antigen gene, a member of the carcinoembryonic antigen gene family up-regulated in colorectal carcinomas.
Author: Koops, M D|Thompson, J|Zimmermann, W|Stanners, C P
PMID: 9654079
Journal: Nihon Geka Gakkai Zasshi. 1998 Jun;99(6):373-8.
Title: [A novel approach for cancer chemoprevention referred to as "gene-regulating chemoprevention"].
Author: Nakano, K|Yamagishi, H|Oka, T|Sakai, T
PMID: 9695075
Journal: Nucleic Acids Res. 2000 Aug 1;28(15):2969-76.
Title: Gut-enriched Kruppel-like factor represses cyclin D1 promoter activity through Sp1 motif.
Author: Shie, J L|Chen, Z Y|Fu, M|Pestell, R G|Tseng, C C
PMID: 10908361
Journal: Oncogene. 2000 Sep 21;19(40):4660-7.
Title: Repression of transforming growth factor-beta receptor type I promoter expression by Sp1 deficiency.
Author: Periyasamy, S|Ammanamanchi, S|Tillekeratne, M P|Brattain, M G
PMID: 11030155
Journal: J Biol Chem. 2001 May 25;276(21):18193-9.
Title: p53-dependent transcriptional regulation of the APC promoter in colon cancer cells treated with DNA alkylating agents.
Author: Jaiswal, A S|Narayan, S
PMID: 11279192
Journal: J Biol Chem. 2001 Aug 31;276(35):32854-9.
Title: 5-azaC treatment enhances expression of transforming growth factor-beta receptors through down-regulation of Sp3.
Author: Ammanamanchi, S|Brattain, M G
PMID: 11443124
Journal: Oncogene. 2002 Dec 5;21(55):8477-85.
Title: The Sp1 transcription factor contributes to the tumor necrosis factor-induced expression of the angiogenic factor thymidine phosphorylase in human colon carcinoma cells.
Author: Zhu, Geng Hui|Lenzi, Michelle|Schwartz, Edward L
PMID: 12466967
Journal: J Biol Chem. 2004 Apr 2;279(14):14287-93. Epub 2004 Jan 23.
Title: Prostaglandin E2 synergistically enhances receptor tyrosine kinase-dependent signaling system in colon cancer cells.
Author: Shao, Jinyi|Evers, B Mark|Sheng, Hongmiao
PMID: 14742435
Journal: J Immunol. 2004 Mar 15;172(6):3922-9.
Title: Survivin enhances Fas ligand expression via up-regulation of specificity protein 1-mediated gene transcription in colon cancer cells.
Author: Asanuma, Koichi|Tsuji, Naoki|Endoh, Teruo|Yagihashi, Atsuhito|Watanabe, Naoki
PMID: 15004200
Journal: Endocrinology. 2004 Aug;145(8):3769-77. Epub 2004 May 6.
Title: Transcriptional activation of the insulin-like growth factor I receptor gene by the Kruppel-like factor 6 (KLF6) tumor suppressor protein: potential interactions between KLF6 and p53.
Author: Rubinstein, Moran|Idelman, Gila|Plymate, Stephen R|Narla, Goutham|Friedman, Scott L|Werner, Haim
PMID: 15131018
Journal: Exp Cell Res. 2005 May 1;305(2):300-11.
Title: Survivin enhances telomerase activity via up-regulation of specificity protein 1- and c-Myc-mediated human telomerase reverse transcriptase gene transcription.
Author: Endoh, Teruo|Tsuji, Naoki|Asanuma, Koichi|Yagihashi, Atsuhito|Watanabe, Naoki
PMID: 15817155
Journal: Mol Pharmacol. 2005 Aug;68(2):317-29. Epub 2005 May 9.
Title: Cyclooxygenase-2 inhibitors decrease vascular endothelial growth factor expression in colon cancer cells by enhanced degradation of Sp1 and Sp4 proteins.
Author: Abdelrahim, Maen|Safe, Stephen
PMID: 15883203
Journal: Cell Signal. 2005 Dec;17(12):1572-7.
Title: Ciglitazone-induced p27 gene transcriptional activity is mediated through Sp1 and is negatively regulated by the MAPK signaling pathway.
Author: Chen, Fei|Kim, Eugene|Wang, Chia-Chi|Harrison, Lawrence E
PMID: 15951157
Journal: Am J Pathol. 2005 Jul;167(1):233-42.
Title: The loss of sarco/endoplasmic reticulum calcium transport ATPase 3 expression is an early event during the multistep process of colon carcinogenesis.
Author: Brouland, Jean-Philippe|Gelebart, Pascal|Kovacs, Tunde|Enouf, Jocelyne|Grossmann, Johannes|Papp, Bela
PMID: 15972967
Journal: Cell Cycle. 2005 Sep;4(9):1201-15.
Title: Molecular targets and anticancer potential of indole-3-carbinol and its derivatives.
Author: Aggarwal, Bharat B|Ichikawa, Haruyo
PMID: 16082211
Journal: Oncol Res. 2005;15(5):265-79.
Title: A bisanthracycline (WP631) represses uPAR gene expression and cell migration of RKO colon cancer cells by interfering with transcription factor binding to a chromatin-accessible -148/-124 promoter region.
Author: Nair, Rajesh R|Wang, Heng|Jamaluddin, M S|Fokt, Izabella|Priebe, Waldemar|Boyd, Douglas D
PMID: 16261846
Journal: J Cell Biochem. 2006 Aug 15;98(6):1450-6.
Title: Functional role of VDR in the activation of p27Kip1 by the VDR/Sp1 complex.
Author: Cheng, Hsuen-Tsen|Chen, Jing-Yi|Huang, Yu-Chun|Chang, Hui-Chiu|Hung, Wen-Chun
PMID: 16518840
Journal: Int J Radiat Oncol Biol Phys. 2006 Oct 1;66(2):500-4.
Title: Prediction of response to chemoradiation in rectal cancer by a gene polymorphism in the epidermal growth factor receptor promoter region.
Author: Spindler, Karen-Lise Garm|Nielsen, Jens Nederby|Lindebjerg, Jan|Brandslund, Ivan|Jakobsen, Anders
PMID: 16757132
Journal: Int J Oncol. 2006 Nov;29(5):1159-65.
Title: Epidermal growth factor receptor analyses in colorectal cancer: a comparison of methods.
Author: Spindler, Karen-Lise Garm|Lindebjerg, Jan|Nielsen, Jens Nederby|Olsen, Dorte Aalund|Bisgard, Claus|Brandslund, Ivan|Jakobsen, Anders
PMID: 17016647
Journal: Int J Mol Med. 2007 Mar;19(3):529-33.
Title: Comparative integromics on FZD7 orthologs: conserved binding sites for PU.1, SP1, CCAAT-box and TCF/LEF/SOX transcription factors within 5'-promoter region of mammalian FZD7 orthologs.
Author: Katoh, Masuko|Katoh, Masaru
PMID: 17273804
Journal: Oncogene. 2007 Jul 5;26(31):4550-62.
Title: Tumor suppressor Pdcd4 inhibits invasion/intravasation and regulates urokinase receptor (u-PAR) gene expression via Sp-transcription factors.
Author: Leupold, J H|Yang, H-S|Colburn, N H|Asangani, I|Post, S|Allgayer, H
PMID: 17297470
Journal: Cancer Res. 2007 Apr 1;67(7):3286-94.
Title: Regulation of vascular endothelial growth factor receptor-1 expression by specificity proteins 1, 3, and 4 in pancreatic cancer cells.
Author: Abdelrahim, Maen|Baker, Cheryl H|Abbruzzese, James L|Sheikh-Hamad, David|Liu, Shengxi|Cho, Sung Dae|Yoon, Kyungsil|Safe, Stephen
PMID: 17409437
Journal: Mol Cancer Res. 2007 May;5(5):485-96.
Title: Src induces urokinase receptor gene expression and invasion/intravasation via activator protein-1/p-c-Jun in colorectal cancer.
Author: Leupold, Jorg H|Asangani, Irfan|Maurer, Gabriele D|Lengyel, Ernst|Post, Stefan|Allgayer, Heike
PMID: 17510314
Journal: Cancer Res. 2007 May 15;67(10):4620-9.
Title: Transcriptional control of the human high mobility group A1 gene: basal and oncogenic Ras-regulated expression.
Author: Cleynen, Isabelle|Huysmans, Christel|Sasazuki, Takehiko|Shirasawa, Senji|Van de Ven, Wim|Peeters, Kristel
PMID: 17510387
Journal: Surgery. 2007 Aug;142(2):163-9.
Title: Sp1 regulates osteopontin expression in SW480 human colon adenocarcinoma cells.
Author: Takami, Yoji|Russell, Michael B|Gao, Chengjiang|Mi, Zhiyong|Guo, Hongtao|Mantyh, Christopher R|Kuo, Paul C
PMID: 17689681
Journal: Int J Oncol. 2007 Oct;31(4):915-22.
Title: The plant alkaloid cryptolepine induces p21WAF1/CIP1 and cell cycle arrest in a human osteosarcoma cell line.
Author: Matsui, Taka-aki|Sowa, Yoshihiro|Murata, Hiroaki|Takagi, Koichi|Nakanishi, Ryoko|Aoki, Shunji|Yoshikawa, Masayuki|Kobayashi, Motomasa|Sakabe, Tomoya|Kubo, Toshikazu|Sakai, Toshiyuki
PMID: 17786325
Journal: J Cell Mol Med. 2008 Apr;12(2):607-21.
Title: Trichostatin A causes p53 to switch oxidative-damaged colorectal cancer cells from cell cycle arrest into apoptosis.
Author: Habold, C|Poehlmann, A|Bajbouj, K|Hartig, R|Korkmaz, K S|Roessner, A|Schneider-Stock, R
PMID: 18419600
Journal: Oncogene. 2008 Aug 7;27(34):4724-32.
Title: NADPH oxidase 1 plays a critical mediating role in oncogenic Ras-induced vascular endothelial growth factor expression.
Author: Komatsu, D|Kato, M|Nakayama, J|Miyagawa, S|Kamata, T
PMID: 18454179
Journal: Mol Biol Cell. 2008 Oct;19(10):4062-75.
Title: HDAC4 promotes growth of colon cancer cells via repression of p21.
Author: Wilson, Andrew J|Byun, Do-Sun|Nasser, Shannon|Murray, Lucas B|Ayyanar, Kanyalakshmi|Arango, Diego|Figueroa, Maria|Melnick, Ari|Kao, Gary D|Augenlicht, Leonard H|Mariadason, John M
PMID: 18632985
Journal: PLoS Genet. 2009 Jan;5(1):e1000334.
Title: Deletion hotspots in AMACR promoter CpG island are cis-regulatory elements controlling the gene expression in the colon.
Author: Zhang, Xiang|Leav, Irwin|Revelo, Monica P|Deka, Ranjan|Medvedovic, Mario|Jiang, Zhong|Ho, Shuk-Mei
PMID: 19148275
Journal: Int J Oncol. 2009 Apr;34(4):1061-8.
Title: Interaction between survivin and aurora-B kinase plays an important role in survivin-mediated up-regulation of human telomerase reverse transcriptase expression.
Author: Furuya, Momoko|Tsuji, Naoki|Kobayashi, Daisuke|Watanabe, Naoki
PMID: 19287963
Journal: Int J Oncol. 2009 May;34(5):1363-72.
Title: Down-regulation of hTERT expression plays an important role in 15-deoxy-Delta12,14-prostaglandin J2-induced apoptosis in cancer cells.
Author: Moriai, Mikako|Tsuji, Naoki|Kobayashi, Daisuke|Kuribayashi, Kageaki|Watanabe, Naoki
PMID: 19360348
Journal: Cancer Biol Ther. 2009 Nov;8(22):2166-74. Epub 2009 Nov 21.
Title: Sp1 upregulates expression of TRF2 and TRF2 inhibition reduces tumorigenesis in human colorectal carcinoma cells.
Author: Dong, Wenjie|Shen, Ruizhe|Wang, Qi|Gao, Yabo|Qi, Xiaoguang|Jiang, He|Yao, Jingjing|Lin, Xiaolin|Wu, Yunlin|Wang, Lifu
PMID: 19783902
Journal: Nagoya J Med Sci. 2009 Sep;71(3-4):127-36.
Title: Mutated ras induced PLD1 gene expression through increased Sp1 transcription factor.
Author: Gao, Siqiang|Murakami, Masashi|Ito, Hiromi|Furuhata, Ayako|Yoshida, Kayo|Tagawa, Yoko|Hagiwara, Kazumi|Takagi, Akira|Kojima, Tetsuhito|Suzuki, Motoshi|Banno, Yoshiko|Nozawa, Yoshinori|Murate, Takashi
PMID: 19994725
Journal: Mol Cancer. 2010 Oct 15;9:276.
Title: Butyrate suppresses expression of neuropilin I in colorectal cell lines through inhibition of Sp1 transactivation.
Author: Yu, Danny C W|Waby, Jennifer S|Chirakkal, Haridasan|Staton, Carolyn A|Corfe, Bernard M
PMID: 20950431
Journal: Neoplasia. 2010 Nov;12(11):856-65.
Title: GATA6 promotes colon cancer cell invasion by regulating urokinase plasminogen activator gene expression.
Author: Belaguli, Narasimhaswamy S|Aftab, Muhammad|Rigi, Mohammed|Zhang, Mao|Albo, Daniel|Berger, David H
PMID: 21076612
Journal: Mol Cancer Res. 2011 Feb;9(2):195-202.
Title: GT-094, a NO-NSAID, inhibits colon cancer cell growth by activation of a reactive oxygen species-microRNA-27a: ZBTB10-specificity protein pathway.
Author: Pathi, Satya S|Jutooru, Indira|Chadalapaka, Gayathri|Sreevalsan, Sandeep|Anand, S|Thatcher, Gregory Rj|Safe, Stephen
PMID: 21156786
Journal: Cancer Sci. 2011 Apr;102(4):742-8.
Title: Apoptotic effect of tolfenamic acid in androgen receptor-independent prostate cancer cell and xenograft tumor through specificity protein 1.
Author: Choi, Eun-Sun|Shim, Jung-Hyun|Jung, Ji-Youn|Kim, Hyeong-Jin|Choi, Kyeong-Hee|Shin, Ji-Ae|Nam, Jeong-Seok|Cho, Nam-Pyo|Cho, Sung-Dae
PMID: 21241418
Journal: J Cell Biochem. 2011 Aug;112(8):2089-96.
Title: Sp1 is a transcription repressor to stanniocalcin-1 expression in TSA-treated human colon cancer cells, HT29.
Author: Law, Alice Y S|Yeung, B H Y|Ching, L Y|Wong, Chris K C
PMID: 21465530
Journal: PLoS One. 2011;6(8):e23754.
Title: PTTG1 attenuates drug-induced cellular senescence.
Author: Tong, Yunguang|Zhao, Weijiang|Zhou, Cuiqi|Wawrowsky, Kolja|Melmed, Shlomo
PMID: 21858218
Journal: BMC Cancer. 2011 Aug 24;11:371.
Title: Betulinic acid inhibits colon cancer cell and tumor growth and induces proteasome-dependent and -independent downregulation of specificity proteins (Sp) transcription factors.
Author: Chintharlapalli, Sudhakar|Papineni, Sabitha|Lei, Ping|Pathi, Satya|Safe, Stephen
PMID: 21864401
Journal: Nutr Cancer. 2011;63(7):1133-42.
Title: Pharmacologic doses of ascorbic acid repress specificity protein (Sp) transcription factors and Sp-regulated genes in colon cancer cells.
Author: Pathi, Satya S|Lei, Ping|Sreevalsan, Sandeep|Chadalapaka, Gayathri|Jutooru, Indira|Safe, Stephen
PMID: 21919647
Journal: Cancer Lett. 2011 Dec 26;313(1):91-8.
Title: Knockdown of RAGE expression inhibits colorectal cancer cell invasion and suppresses angiogenesis in vitro and in vivo.
Author: Liang, Huasheng|Zhong, Yuhua|Zhou, Shaobi|Peng, Liang
PMID: 21945853
Journal: Neoplasma. 2012;59(3):341-7.
Title: Transcription of promoter from the human APRIL gene regulated by Sp1 and NF-kB.
Author: Xu, J|Ding, W F|Shao, K K|Wang, X D|Wang, G H|Li, H Q|Wang, H M
PMID: 22296504
Journal: J Biomed Sci. 2012 Oct 25;19:91.
Title: CXC chemokine ligand 12/stromal cell-derived factor-1 regulates cell adhesion in human colon cancer cells by induction of intercellular adhesion molecule-1.
Author: Tung, Shui-Yi|Chang, Shun-Fu|Chou, Ming-Hui|Huang, Wen-Shih|Hsieh, Yung-Yu|Shen, Chien-Heng|Kuo, Hsing-Chun|Chen, Cheng-Nan
PMID: 23098564
Journal: PLoS One. 2012;7(10):e48189.
Title: Transcriptional control of the multi-drug transporter ABCB1 by transcription factor Sp3 in different human tissues.
Author: Gromnicova, Radka|Romero, Ignacio|Male, David
PMID: 23133566
Journal: J Pathol. 2013 Jan;229(1):12-24.
Title: SP1 mediates the link between methylation of the tumour suppressor miR-149 and outcome in colorectal cancer.
Author: Wang, Feng|Ma, Yan-Lei|Zhang, Peng|Shen, Tong-Yi|Shi, Chen-Zhang|Yang, Yong-Zhi|Moyer, Mary-Pat|Zhang, Hui-Zhen|Chen, Hong-Qi|Liang, Yong|Qin, Huan-Long
PMID: 22821729
Journal: J Steroid Biochem Mol Biol. 2013 Jul;136:296-9.
Title: Epigenetic regulation of the 1,25-dihydroxyvitamin D3 24-hydroxylase (CYP24A1) in colon cancer cells.
Author: Hobaus, Julia|Fetahu, Irfete Sh|Khorchide, Maya|Manhardt, Teresa|Kallay, Eniko
PMID: 22940288
Journal: Cell Oncol (Dordr). 2013 Apr;36(2):155-67.
Title: Epigenetic control of HNF-4alpha in colon carcinoma cells affects MUC4 expression and malignancy.
Author: Algamas-Dimantov, Anna|Yehuda-Shnaidman, Einav|Peri, Irena|Schwartz, Betty
PMID: 23307400
Journal: Biol Pharm Bull. 2013;36(2):299-304.
Title: Coffee reduces SULT1E1 expression in human colon carcinoma Caco-2 cells.
Author: Isshiki, Marina|Ohta, Haruka|Tamura, Hiroomi
PMID: 23370358
Journal: Mol Nutr Food Res. 2013 Sep;57(9):1638-48.
Title: The drug resistance suppression induced by curcuminoids in colon cancer SW-480 cells is mediated by reactive oxygen species-induced disruption of the microRNA-27a-ZBTB10-Sp axis.
Author: Noratto, Giuliana D|Jutooru, Indira|Safe, Stephen|Angel-Morales, Gabriela|Mertens-Talcott, Susanne U
PMID: 23471840
Journal: Nutr Cancer. 2013;65(3):494-504.
Title: Resveratrol and quercetin in combination have anticancer activity in colon cancer cells and repress oncogenic microRNA-27a.
Author: Del Follo-Martinez, Armando|Banerjee, Nivedita|Li, Xiangrong|Safe, Stephen|Mertens-Talcott, Susanne
PMID: 23530649
Journal: Biochim Biophys Acta. 2013 Aug;1830(8):4053-64.
Title: Simvastatin induced HCT116 colorectal cancer cell apoptosis through p38MAPK-p53-survivin signaling cascade.
Author: Chang, Hang-Lung|Chen, Chih-Yu|Hsu, Ya-Fen|Kuo, Wen-Shin|Ou, George|Chiu, Pei-Ting|Huang, Yu-Han|Hsu, Ming-Jen
PMID: 23583370
Journal: Int J Mol Med. 2013 Sep;32(3):703-8.
Title: Molecular basis for the expression of major vault protein induced by hyperosmotic stress in SW620 human colon cancer cells.
Author: Tajitsu, Yusuke|Ikeda, Ryuji|Nishizawa, Yukihiko|Mataki, Hirofumi|Che, Xiao-Fang|Sumizawa, Tomoyuki|Nitta, Mina|Yamaguchi, Tatsuya|Yamamoto, Masatatsu|Tabata, Sho|Akiyama, Shin-Ichi|Yamada, Katsushi|Furukawa, Tatsuhiko|Takeda, Yasuo
PMID: 23820674
Journal: Oncol Rep. 2013 Oct;30(4):1782-92.
Title: Inhibition of the transcription factor Sp1 suppresses colon cancer stem cell growth and induces apoptosis in vitro and in nude mouse xenografts.
Author: Zhao, Yingying|Zhang, Wenjing|Guo, Zheng|Ma, Feng|Wu, Yao|Bai, Yang|Gong, Wei|Chen, Ye|Cheng, Tianming|Zhi, Fachao|Zhang, Yali|Wang, Jide|Jiang, Bo
PMID: 23877322
Journal: Carcinogenesis. 2013 Nov;34(11):2610-21.
Title: Trichostatin-A modulates claudin-1 mRNA stability through the modulation of Hu antigen R and tristetraprolin in colon cancer cells.
Author: Sharma, Ashok|Bhat, Ajaz A|Krishnan, Moorthy|Singh, Amar B|Dhawan, Punita
PMID: 23880304
Journal: Mol Cancer Ther. 2013 Nov;12(11):2483-93.
Title: The cannabinoid WIN 55,212-2 decreases specificity protein transcription factors and the oncogenic cap protein eIF4E in colon cancer cells.
Author: Sreevalsan, Sandeep|Safe, Stephen
PMID: 24030632
Journal: Carcinogenesis. 2014 Feb;35(2):302-14.
Title: ZEB2-Sp1 cooperation induces invasion by upregulating cadherin-11 and integrin alpha5 expression.
Author: Nam, Eun-Hee|Lee, Yunhee|Zhao, Xue-Feng|Park, Young-Kyu|Lee, Jung Weon|Kim, Semi
PMID: 24130169
Journal: Oncol Rep. 2014 Jan;31(1):197-201.
Title: Regulation of major vault protein expression by upstream stimulating factor 1 in SW620 human colon cancer cells.
Author: Ikeda, Ryuji|Nishizawa, Yukihiko|Tajitsu, Yusuke|Minami, Kentaro|Mataki, Hironori|Masuda, Shogo|Furukawa, Tatsuhiko|Akiyama, Shin-Ichi|Yamada, Katsushi|Takeda, Yasuo
PMID: 24173679
Journal: Oncogene. 2015 Aug 13;34(33):4412-20.
Title: Impact of the Mdm2(SNP309-G) allele on a murine model of colorectal cancer.
Author: Zhang, X|Pageon, L|Post, S M
PMID: 25435368
Journal: Int J Oncol. 2015 Mar;46(3):1328-42.
Title: Overexpression of PGC1alpha enhances cell proliferation and tumorigenesis of HEK293 cells through the upregulation of Sp1 and Acyl-CoA binding protein.
Author: Shin, Sung-Won|Yun, Seong-Hoon|Park, Eun-Seon|Jeong, Jin-Sook|Kwak, Jong-Young|Park, Joo-In
PMID: 25585584
Journal: Oncotarget. 2015 Apr 10;6(10):8132-43.
Title: Silencing of voltage-gated potassium channel KV9.3 inhibits proliferation in human colon and lung carcinoma cells.
Author: Lee, Jeong-Ha|Park, Jun-Won|Byun, Jun Kyu|Kim, Hark Kyun|Ryu, Pan Dong|Lee, So Yeong|Kim, Dae-Yong
PMID: 25924237
Journal: Med Sci Monit. 2015 May 9;21:1333-44.
Title: Identification of transcriptional factors and key genes in primary osteoporosis by DNA microarray.
Author: Xie, Wengui|Ji, Lixin|Zhao, Teng|Gao, Pengfei
PMID: 25957414
Journal: PLoS One. 2015 Aug 21;10(8):e0135958.
Title: Genome Wide Expression Profiling of Cancer Cell Lines Cultured in Microgravity Reveals Significant Dysregulation of Cell Cycle and MicroRNA Gene Networks.
Author: Vidyasekar, Prasanna|Shyamsunder, Pavithra|Arun, Rajpranap|Santhakumar, Rajalakshmi|Kapadia, Nand Kishore|Kumar, Ravi|Verma, Rama Shanker
PMID: 26295583
Journal: BMC Cancer. 2015 Dec 16;15:974.
Title: Sulindac sulfide inhibits colon cancer cell growth and downregulates specificity protein transcription factors.
Author: Li, Xi|Pathi, Satya S|Safe, Stephen
PMID: 26673922
Journal: Oncotarget. 2016 Jan 19;7(3):3186-200.
Title: Combination of tolfenamic acid and curcumin induces colon cancer cell growth inhibition through modulating specific transcription factors and reactive oxygen species.
Author: Sankpal, Umesh T|Nagaraju, Ganji Purnachandra|Gottipolu, Sriharika R|Hurtado, Myrna|Jordan, Christopher G|Simecka, Jerry W|Shoji, Mamoru|El-Rayes, Bassel|Basha, Riyaz
PMID: 26672603
Journal: Sci Rep. 2016 Jan 13;6:19229.
Title: FAS rs2234767 and rs1800682 polymorphisms jointly contributed to risk of colorectal cancer by affecting SP1/STAT1 complex recruitment to chromatin.
Author: Wang, Shizhi|Wu, Shenshen|Meng, Qingtao|Li, Xiaobo|Zhang, Jinchun|Chen, Rui|Wang, Meilin
PMID: 26759270
Journal: Tumour Biol. 2016 May;37(5):5751-60.
Title: Tumor suppressor NGX6 inhibits the growth and metastasis of multiple cancers.
Author: He, Shiwei|Zhong, Yancheng|Shuai, Cijun|Gao, Dan|Wei, Pingpin|Li, Guiyuan|Peng, Shuping
PMID: 26880583
Journal: Oncol Rep. 2016 Jul;36(1):487-93.
Title: miR-375 inhibits the invasion and metastasis of colorectal cancer via targeting SP1 and regulating EMT-associated genes.
Author: Cui, Fengyun|Wang, Shuyang|Lao, Iweng|Zhou, Chunxian|Kong, Hui|Bayaxi, Nayima|Li, Jiali|Chen, Qi|Zhu, Tengfang|Zhu, Hongguang
PMID: 27222350
Journal: Oncotarget. 2016 Aug 2;7(31):50333-50348.
Title: 5-FU targets rpL3 to induce mitochondrial apoptosis via cystathionine-beta-synthase in colon cancer cells lacking p53.
Author: Pagliara, Valentina|Saide, Assunta|Mitidieri, Emma|d'Emmanuele di Villa Bianca, Roberta|Sorrentino, Raffaella|Russo, Giulia|Russo, Annapina
PMID: 27385096
Journal: Biomed Pharmacother. 2016 Oct;83:496-501.
Title: TEAD1 enhances proliferation via activating SP1 in colorectal cancer.
Author: Yu, Min-Hao|Zhang, Wei
PMID: 27434865
Journal: FEBS Open Bio. 2016 Jul 8;6(8):794-806.
Title: Transcriptome analysis of copper homeostasis genes reveals coordinated upregulation of SLC31A1,SCO1, and COX11 in colorectal cancer.
Author: Barresi, Vincenza|Trovato-Salinaro, Angela|Spampinato, Giorgia|Musso, Nicolo|Castorina, Sergio|Rizzarelli, Enrico|Condorelli, Daniele Filippo
PMID: 27516958
Journal: Sci Rep. 2016 Sep 14;6:33153.
Title: MDM2 promoter SNP55 (rs2870820) affects risk of colon cancer but not breast-, lung-, or prostate cancer.
Author: Helwa, Reham|Gansmo, Liv B|Romundstad, Pal|Hveem, Kristian|Vatten, Lars|Ryan, Brid M|Harris, Curtis C|Lonning, Per E|Knappskog, Stian
PMID: 27624283
Journal: Mol Carcinog. 2017 Feb;56(2):735-750.
Title: Induction of cell differentiation activates transcription of the Sarco/Endoplasmic Reticulum calcium-ATPase 3 gene (ATP2A3) in gastric and colon cancer cells.
Author: Flores-Peredo, Lucia|Rodriguez, Gabriela|Zarain-Herzberg, Angel
PMID: 27433831
Journal: Int J Oncol. 2017 Jan;50(1):252-262.
Title: Glyceraldehyde-3-phosphate dehydrogenase promotes cancer growth and metastasis through upregulation of SNAIL expression.
Author: Liu, Kaiyan|Tang, Zhenjie|Huang, Amin|Chen, Ping|Liu, Panpan|Yang, Jing|Lu, Wenhua|Liao, Jianwei|Sun, Yicheng|Wen, Shijun|Hu, Yumin|Huang, Peng
PMID: 27878251
Journal: Sci Rep. 2017 Feb 22;7:43081.
Title: Antitumorigenic effect of atmospheric-pressure dielectric barrier discharge on human colorectal cancer cells via regulation of Sp1 transcription factor.
Author: Han, Duksun|Cho, Jin Hyoung|Lee, Ra Ham|Bang, Woong|Park, Kyungho|Kim, Minseok S|Shim, Jung-Hyun|Chae, Jung-Il|Moon, Se Youn
PMID: 28225083
Journal: Biochim Biophys Acta Gen Subj. 2017 May;1861(5 Pt A):1065-1074.
Title: Glucose-derived AGEs promote migration and invasion of colorectal cancer by up-regulating Sp1 expression.
Author: Deng, Ruyuan|Wu, Huo|Ran, Hui|Kong, Xiang|Hu, Lei|Wang, Xiao|Su, Qing
PMID: 28237576
Journal: Oncotarget. 2017 May 30;8(22):36266-36278.
Title: MicroRNA-22 suppresses the growth, migration and invasion of colorectal cancer cells through a Sp1 negative feedback loop.
Author: Xia, Shu-Sen|Zhang, Guang-Jun|Liu, Zuo-Liang|Tian, Hong-Peng|He, Yi|Meng, Chang-Yuan|Li, Li-Fa|Wang, Zi-Wei|Zhou, Tong
PMID: 28422727
Journal: Crit Rev Oncol Hematol. 2017 May;113:1-7.
Title: Specificity protein 1: Its role in colorectal cancer progression and metastasis.
Author: Bajpai, Richa|Nagaraju, Ganji Purnachandra
PMID: 28427500
Journal: Biomed Res Int. 2017;2017:2769140.
Title: Screening of Tumor Suppressor Genes in Metastatic Colorectal Cancer.
Author: Qi, Lu|Ding, Yanqing
PMID: 28473981
Journal: Sci Rep. 2017 Sep 8;7(1):11000.
Title: MIER3 suppresses colorectal cancer progression by down-regulating Sp1, inhibiting epithelial-mesenchymal transition.
Author: Peng, Man|Hu, Yukun|Song, Wen|Duan, Shiyu|Xu, Qiong|Ding, Yanqing|Geng, Jian|Zhou, Jun
PMID: 28887525
Journal: Mol Med Rep. 2017 Dec;16(6):9692-9700.
Title: MicroRNA760 inhibits cell proliferation and invasion of colorectal cancer by targeting the SP1mediated PTEN/AKT signalling pathway.
Author: Li, Xiaoyan|Ding, Yuansheng|Liu, Naiqing|Sun, Qinli|Zhang, Jie
PMID: 29039575
Journal: Oncol Rep. 2017 Dec;38(6):3497-3506.
Title: Expression of fatty acid synthase is regulated by PGC1alpha and contributes to increased cell proliferation.
Author: Yun, Seong-Hoon|Shin, Sung-Won|Park, Joo-In
PMID: 29130104
Journal: Br J Cancer. 2018 Jan;118(1):106-116.
Title: Mechanisms of inactivation of the tumour suppressor gene RHOA in colorectal cancer.
Author: Dopeso, Higinio|Rodrigues, Paulo|Bilic, Josipa|Bazzocco, Sarah|Carton-Garcia, Fernando|Macaya, Irati|de Marcondes, Priscila Guimaraes|Anguita, Estefania|Masanas, Marc|Jimenez-Flores, Lizbeth M|Martinez-Barriocanal, Agueda|Nieto, Rocio|Segura, Miguel F|Sch
PMID: 29206819
Journal: Dig Dis Sci. 2018 Feb;63(2):395-402.
Title: Speckle-Type POZ Protein Down-Regulates Matrix Metalloproteinase 2 Expression via Sp1/PI3K/Akt Signaling Pathway in Colorectal Cancer.
Author: Zhang, Shouhua|Xiao, Juhua|Chai, Yong|Hong, Zhengdong|Liu, Zhiqiang|Yuan, Rongfa|Luo, Zhipeng|Zhou, Xin|Lucero-Prisno, Don Eliseo III|Huang, Kai
PMID: 29260353
Journal: J Cell Biochem. 2018 Jul;119(7):5350-5358.
Title: Temozolomide analog PMX 465 downregulates MGMT expression in HCT116 colorectal carcinoma cells.
Author: Yang, Zhikuan|Wei, Danping|Liu, Feifei|Liu, Jing|Wu, Xiaoming|Stevens, Malcolm F G|Bradshaw, Tracey D|Luo, Ying|Zhang, Jihong
PMID: 29331023
Journal: Eur Rev Med Pharmacol Sci. 2018 Jan;22(2):405-411.
Title: The inhibitory effect of miR-375 targeting sp1 in colorectal cancer cell proliferation.
Author: Liu, X-H|Wang, J|Dong, Y-H
PMID: 29424897
Journal: Int J Cancer. 2018 Jul 15;143(2):289-297.
Title: DR4 mediates the progression, invasion, metastasis and survival of colorectal cancer through the Sp1/NF1 switch axis on genomic locus.
Author: Wu, Shenshen|Meng, Qingtao|Zhang, Chengcheng|Sun, Hao|Lu, Runze|Gao, Na|Yang, Hongbao|Li, Xiaobo|Aschner, Michael|Chen, Rui
PMID: 29446085
Journal: Oncogene. 2018 Jun;37(25):3440-3455.
Title: Mutant KRAS promotes liver metastasis of colorectal cancer, in part, by upregulating the MEK-Sp1-DNMT1-miR-137-YB-1-IGF-IR signaling pathway.
Author: Chu, Po-Chen|Lin, Peng-Chan|Wu, Hsing-Yu|Lin, Kuen-Tyng|Wu, Christina|Bekaii-Saab, Tanios|Lin, Yih-Jyh|Lee, Chung-Ta|Lee, Jeng-Chang|Chen, Ching-Shih
PMID: 29559746
Journal: Onco Targets Ther. 2018 Mar 19;11:1543-1552.
Title: Novel long noncoding RNA GACAT3 promotes colorectal cancer cell proliferation, invasion, and migration through miR-149.
Author: Zhou, Weiwei|Wang, Lei|Miao, Yu|Xing, Rongge
PMID: 29593420
Journal: Int J Mol Sci. 2018 Jun 29;19(7). pii: ijms19071909.
Title: The Curcumin Analog CH-5 Exerts Anticancer Effects in Human Osteosarcoma Cells via Modulation of Transcription Factors p53/Sp1.
Author: Lima, Felipe Teixeira|Seba, Viviane|Silva, Gabriel|Torrezan, Guilherme Silva|Polaquini, Carlos Roberto|Pinhanelli, Vitor Caressato|Baek, Seung J|Fachin, Ana Lucia|Regasini, Luis Octavio|Marins, Mozart
PMID: 29966255
Journal: Sensors (Basel). 2018 Aug 6;18(8). pii: s18082573.
Title: Screening Method for Anti-Colon Cancer Drugs Using Two Sensor Cell Lines with Human beta4-Galactosyltransferase 4 Gene Promoters.
Author: Fukushima, Naomichi|Sugiyama, Atena|Sato, Takeshi
PMID: 30082623
Journal: Mol Pharmacol. 2018 Oct;94(4):1187-1196.
Title: Bortezomib Targets Sp Transcription Factors in Cancer Cells.
Author: Karki, Keshav|Harishchandra, Sneha|Safe, Stephen
PMID: 30115673
Journal: Cell Death Dis. 2018 Sep 24;9(10):982.
Title: SP1-induced lncRNA-ZFAS1 contributes to colorectal cancer progression via the miR-150-5p/VEGFA axis.
Author: Chen, Xiaoxiang|Zeng, Kaixuan|Xu, Mu|Hu, Xiuxiu|Liu, Xiangxiang|Xu, Tao|He, Bangshun|Pan, Yuqin|Sun, Huiling|Wang, Shukui
PMID: 30250022
Journal: Mol Cancer. 2018 Sep 28;17(1):141.
Title: The long noncoding RNA SNHG1 regulates colorectal cancer cell growth through interactions with EZH2 and miR-154-5p.
Author: Xu, Mu|Chen, Xiaoxiang|Lin, Kang|Zeng, Kaixuan|Liu, Xiangxiang|Pan, Bei|Xu, Xueni|Xu, Tao|Hu, Xiuxiu|Sun, Li|He, Bangshun|Pan, Yuqin|Sun, Huiling|Wang, Shukui
PMID: 30266084
Journal: Anticancer Drugs. 2018 Oct 22.
Title: Baicalin induces apoptosis in SW480 cells through downregulation of the SP1 transcription factor.
Author: Ma, Wenkang|Liu, Xueyuan|Du, Wei
PMID: 30362980