Primary Site >> Colorectal Cancer
Gene >> SP1
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Ref: Serum-SP1-pregnancy-specific-beta-glycoprotein in choriocarcinoma and other neoplastic disease. PMID: 76123 |
Ref: Tumor-associated antigens in polyps and carcinoma of the human large bowel. PMID: 6164469 |
Ref: Reduced tumorigenicity of murine tumor cells secreting gamma-interferon is due to nonspecific host responses and is unrelated to class I major histocompatibility complex expression. PMID: 1900037 |
Ref: In vitro and in vivo footprint analysis of the promoter of carcinoembryonic antigen in colon carcinoma cells: effects of interferon gamma treatment. PMID: 7641207 |
Ref: Induction of the transcription factor AP-1 in cultured human colon adenocarcinoma cells following exposure to bile acids. PMID: 8631127 Ref: Androgen induces ornithine decarboxylase gene expression in colonic cell line HT-29. PMID: 8878500 |
Ref: Hypermethylation of the WT1 and calcitonin gene promoter regions at chromosome 11p in human colorectal cancer. PMID: 9365158 |
Ref: Identification of a goblet cell-specific enhancer element in the rat intestinal trefoil factor gene promoter bound by a goblet cell nuclear protein. PMID: 9446622 Ref: Modulation of O-linked N-acetylglucosamine levels on nuclear and cytoplasmic proteins in vivo using the peptide O-GlcNAc-beta-N-acetylglucosaminidase inhibitor O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino-N-phenylcarbamate. PMID: 9452489 Ref: Transcriptional regulation of the non-specific cross-reacting antigen gene, a member of the carcinoembryonic antigen gene family up-regulated in colorectal carcinomas. PMID: 9654079 Ref: [A novel approach for cancer chemoprevention referred to as "gene-regulating chemoprevention"]. PMID: 9695075 |
Ref: Gut-enriched Kruppel-like factor represses cyclin D1 promoter activity through Sp1 motif. PMID: 10908361 Ref: Repression of transforming growth factor-beta receptor type I promoter expression by Sp1 deficiency. PMID: 11030155 |
Ref: p53-dependent transcriptional regulation of the APC promoter in colon cancer cells treated with DNA alkylating agents. PMID: 11279192 Ref: 5-azaC treatment enhances expression of transforming growth factor-beta receptors through down-regulation of Sp3. PMID: 11443124 |
Ref: The Sp1 transcription factor contributes to the tumor necrosis factor-induced expression of the angiogenic factor thymidine phosphorylase in human colon carcinoma cells. PMID: 12466967 |
Ref: Prostaglandin E2 synergistically enhances receptor tyrosine kinase-dependent signaling system in colon cancer cells. PMID: 14742435 Ref: Survivin enhances Fas ligand expression via up-regulation of specificity protein 1-mediated gene transcription in colon cancer cells. PMID: 15004200 Ref: Transcriptional activation of the insulin-like growth factor I receptor gene by the Kruppel-like factor 6 (KLF6) tumor suppressor protein: potential interactions between KLF6 and p53. PMID: 15131018 |
Ref: Survivin enhances telomerase activity via up-regulation of specificity protein 1- and c-Myc-mediated human telomerase reverse transcriptase gene transcription. PMID: 15817155 Ref: Cyclooxygenase-2 inhibitors decrease vascular endothelial growth factor expression in colon cancer cells by enhanced degradation of Sp1 and Sp4 proteins. PMID: 15883203 Ref: Ciglitazone-induced p27 gene transcriptional activity is mediated through Sp1 and is negatively regulated by the MAPK signaling pathway. PMID: 15951157 Ref: The loss of sarco/endoplasmic reticulum calcium transport ATPase 3 expression is an early event during the multistep process of colon carcinogenesis. PMID: 15972967 Ref: Molecular targets and anticancer potential of indole-3-carbinol and its derivatives. PMID: 16082211 Ref: A bisanthracycline (WP631) represses uPAR gene expression and cell migration of RKO colon cancer cells by interfering with transcription factor binding to a chromatin-accessible -148/-124 promoter region. PMID: 16261846 |
Ref: Functional role of VDR in the activation of p27Kip1 by the VDR/Sp1 complex. PMID: 16518840 Ref: Prediction of response to chemoradiation in rectal cancer by a gene polymorphism in the epidermal growth factor receptor promoter region. PMID: 16757132 Ref: Epidermal growth factor receptor analyses in colorectal cancer: a comparison of methods. PMID: 17016647 |
Ref: Comparative integromics on FZD7 orthologs: conserved binding sites for PU.1, SP1, CCAAT-box and TCF/LEF/SOX transcription factors within 5'-promoter region of mammalian FZD7 orthologs. PMID: 17273804 Ref: Tumor suppressor Pdcd4 inhibits invasion/intravasation and regulates urokinase receptor (u-PAR) gene expression via Sp-transcription factors. PMID: 17297470 Ref: Regulation of vascular endothelial growth factor receptor-1 expression by specificity proteins 1, 3, and 4 in pancreatic cancer cells. PMID: 17409437 Ref: Src induces urokinase receptor gene expression and invasion/intravasation via activator protein-1/p-c-Jun in colorectal cancer. PMID: 17510314 Ref: Transcriptional control of the human high mobility group A1 gene: basal and oncogenic Ras-regulated expression. PMID: 17510387 Ref: Sp1 regulates osteopontin expression in SW480 human colon adenocarcinoma cells. PMID: 17689681 Ref: The plant alkaloid cryptolepine induces p21WAF1/CIP1 and cell cycle arrest in a human osteosarcoma cell line. PMID: 17786325 |
Ref: Trichostatin A causes p53 to switch oxidative-damaged colorectal cancer cells from cell cycle arrest into apoptosis. PMID: 18419600 Ref: NADPH oxidase 1 plays a critical mediating role in oncogenic Ras-induced vascular endothelial growth factor expression. PMID: 18454179 Ref: HDAC4 promotes growth of colon cancer cells via repression of p21. PMID: 18632985 |
Ref: Deletion hotspots in AMACR promoter CpG island are cis-regulatory elements controlling the gene expression in the colon. PMID: 19148275 Ref: Interaction between survivin and aurora-B kinase plays an important role in survivin-mediated up-regulation of human telomerase reverse transcriptase expression. PMID: 19287963 Ref: Down-regulation of hTERT expression plays an important role in 15-deoxy-Delta12,14-prostaglandin J2-induced apoptosis in cancer cells. PMID: 19360348 Ref: Sp1 upregulates expression of TRF2 and TRF2 inhibition reduces tumorigenesis in human colorectal carcinoma cells. PMID: 19783902 Ref: Mutated ras induced PLD1 gene expression through increased Sp1 transcription factor. PMID: 19994725 |
Ref: Butyrate suppresses expression of neuropilin I in colorectal cell lines through inhibition of Sp1 transactivation. PMID: 20950431 Ref: GATA6 promotes colon cancer cell invasion by regulating urokinase plasminogen activator gene expression. PMID: 21076612 |
Ref: GT-094, a NO-NSAID, inhibits colon cancer cell growth by activation of a reactive oxygen species-microRNA-27a: ZBTB10-specificity protein pathway. PMID: 21156786 Ref: Apoptotic effect of tolfenamic acid in androgen receptor-independent prostate cancer cell and xenograft tumor through specificity protein 1. PMID: 21241418 Ref: Sp1 is a transcription repressor to stanniocalcin-1 expression in TSA-treated human colon cancer cells, HT29. PMID: 21465530 Ref: PTTG1 attenuates drug-induced cellular senescence. PMID: 21858218 Ref: Betulinic acid inhibits colon cancer cell and tumor growth and induces proteasome-dependent and -independent downregulation of specificity proteins (Sp) transcription factors. PMID: 21864401 Ref: Pharmacologic doses of ascorbic acid repress specificity protein (Sp) transcription factors and Sp-regulated genes in colon cancer cells. PMID: 21919647 Ref: Knockdown of RAGE expression inhibits colorectal cancer cell invasion and suppresses angiogenesis in vitro and in vivo. PMID: 21945853 |
Ref: Transcription of promoter from the human APRIL gene regulated by Sp1 and NF-kB. PMID: 22296504 Ref: CXC chemokine ligand 12/stromal cell-derived factor-1 regulates cell adhesion in human colon cancer cells by induction of intercellular adhesion molecule-1. PMID: 23098564 Ref: Transcriptional control of the multi-drug transporter ABCB1 by transcription factor Sp3 in different human tissues. PMID: 23133566 |
Ref: SP1 mediates the link between methylation of the tumour suppressor miR-149 and outcome in colorectal cancer. PMID: 22821729 Ref: Epigenetic regulation of the 1,25-dihydroxyvitamin D3 24-hydroxylase (CYP24A1) in colon cancer cells. PMID: 22940288 Ref: Epigenetic control of HNF-4alpha in colon carcinoma cells affects MUC4 expression and malignancy. PMID: 23307400 Ref: Coffee reduces SULT1E1 expression in human colon carcinoma Caco-2 cells. PMID: 23370358 Ref: The drug resistance suppression induced by curcuminoids in colon cancer SW-480 cells is mediated by reactive oxygen species-induced disruption of the microRNA-27a-ZBTB10-Sp axis. PMID: 23471840 Ref: Resveratrol and quercetin in combination have anticancer activity in colon cancer cells and repress oncogenic microRNA-27a. PMID: 23530649 Ref: Simvastatin induced HCT116 colorectal cancer cell apoptosis through p38MAPK-p53-survivin signaling cascade. PMID: 23583370 Ref: Molecular basis for the expression of major vault protein induced by hyperosmotic stress in SW620 human colon cancer cells. PMID: 23820674 Ref: Inhibition of the transcription factor Sp1 suppresses colon cancer stem cell growth and induces apoptosis in vitro and in nude mouse xenografts. PMID: 23877322 Ref: Trichostatin-A modulates claudin-1 mRNA stability through the modulation of Hu antigen R and tristetraprolin in colon cancer cells. PMID: 23880304 Ref: The cannabinoid WIN 55,212-2 decreases specificity protein transcription factors and the oncogenic cap protein eIF4E in colon cancer cells. PMID: 24030632 |
Ref: ZEB2-Sp1 cooperation induces invasion by upregulating cadherin-11 and integrin alpha5 expression. PMID: 24130169 Ref: Regulation of major vault protein expression by upstream stimulating factor 1 in SW620 human colon cancer cells. PMID: 24173679 |
Ref: Impact of the Mdm2(SNP309-G) allele on a murine model of colorectal cancer. PMID: 25435368 Ref: Overexpression of PGC1alpha enhances cell proliferation and tumorigenesis of HEK293 cells through the upregulation of Sp1 and Acyl-CoA binding protein. PMID: 25585584 Ref: Silencing of voltage-gated potassium channel KV9.3 inhibits proliferation in human colon and lung carcinoma cells. PMID: 25924237 Ref: Identification of transcriptional factors and key genes in primary osteoporosis by DNA microarray. PMID: 25957414 Ref: Genome Wide Expression Profiling of Cancer Cell Lines Cultured in Microgravity Reveals Significant Dysregulation of Cell Cycle and MicroRNA Gene Networks. PMID: 26295583 Ref: Sulindac sulfide inhibits colon cancer cell growth and downregulates specificity protein transcription factors. PMID: 26673922 |
Ref: Combination of tolfenamic acid and curcumin induces colon cancer cell growth inhibition through modulating specific transcription factors and reactive oxygen species. PMID: 26672603 Ref: FAS rs2234767 and rs1800682 polymorphisms jointly contributed to risk of colorectal cancer by affecting SP1/STAT1 complex recruitment to chromatin. PMID: 26759270 Ref: Tumor suppressor NGX6 inhibits the growth and metastasis of multiple cancers. PMID: 26880583 Ref: miR-375 inhibits the invasion and metastasis of colorectal cancer via targeting SP1 and regulating EMT-associated genes. PMID: 27222350 Ref: 5-FU targets rpL3 to induce mitochondrial apoptosis via cystathionine-beta-synthase in colon cancer cells lacking p53. PMID: 27385096 Ref: TEAD1 enhances proliferation via activating SP1 in colorectal cancer. PMID: 27434865 Ref: Transcriptome analysis of copper homeostasis genes reveals coordinated upregulation of SLC31A1,SCO1, and COX11 in colorectal cancer. PMID: 27516958 Ref: MDM2 promoter SNP55 (rs2870820) affects risk of colon cancer but not breast-, lung-, or prostate cancer. PMID: 27624283 |
Ref: Induction of cell differentiation activates transcription of the Sarco/Endoplasmic Reticulum calcium-ATPase 3 gene (ATP2A3) in gastric and colon cancer cells. PMID: 27433831 Ref: Glyceraldehyde-3-phosphate dehydrogenase promotes cancer growth and metastasis through upregulation of SNAIL expression. PMID: 27878251 Ref: Antitumorigenic effect of atmospheric-pressure dielectric barrier discharge on human colorectal cancer cells via regulation of Sp1 transcription factor. PMID: 28225083 Ref: Glucose-derived AGEs promote migration and invasion of colorectal cancer by up-regulating Sp1 expression. PMID: 28237576 Ref: MicroRNA-22 suppresses the growth, migration and invasion of colorectal cancer cells through a Sp1 negative feedback loop. PMID: 28422727 Ref: Specificity protein 1: Its role in colorectal cancer progression and metastasis. PMID: 28427500 Ref: Screening of Tumor Suppressor Genes in Metastatic Colorectal Cancer. PMID: 28473981 Ref: MIER3 suppresses colorectal cancer progression by down-regulating Sp1, inhibiting epithelial-mesenchymal transition. PMID: 28887525 Ref: MicroRNA760 inhibits cell proliferation and invasion of colorectal cancer by targeting the SP1mediated PTEN/AKT signalling pathway. PMID: 29039575 Ref: Expression of fatty acid synthase is regulated by PGC1alpha and contributes to increased cell proliferation. PMID: 29130104 |
Ref: Mechanisms of inactivation of the tumour suppressor gene RHOA in colorectal cancer. PMID: 29206819 Ref: Speckle-Type POZ Protein Down-Regulates Matrix Metalloproteinase 2 Expression via Sp1/PI3K/Akt Signaling Pathway in Colorectal Cancer. PMID: 29260353 Ref: Temozolomide analog PMX 465 downregulates MGMT expression in HCT116 colorectal carcinoma cells. PMID: 29331023 Ref: The inhibitory effect of miR-375 targeting sp1 in colorectal cancer cell proliferation. PMID: 29424897 Ref: DR4 mediates the progression, invasion, metastasis and survival of colorectal cancer through the Sp1/NF1 switch axis on genomic locus. PMID: 29446085 Ref: Mutant KRAS promotes liver metastasis of colorectal cancer, in part, by upregulating the MEK-Sp1-DNMT1-miR-137-YB-1-IGF-IR signaling pathway. PMID: 29559746 Ref: Novel long noncoding RNA GACAT3 promotes colorectal cancer cell proliferation, invasion, and migration through miR-149. PMID: 29593420 Ref: The Curcumin Analog CH-5 Exerts Anticancer Effects in Human Osteosarcoma Cells via Modulation of Transcription Factors p53/Sp1. PMID: 29966255 Ref: Screening Method for Anti-Colon Cancer Drugs Using Two Sensor Cell Lines with Human beta4-Galactosyltransferase 4 Gene Promoters. PMID: 30082623 Ref: Bortezomib Targets Sp Transcription Factors in Cancer Cells. PMID: 30115673 Ref: SP1-induced lncRNA-ZFAS1 contributes to colorectal cancer progression via the miR-150-5p/VEGFA axis. PMID: 30250022 Ref: The long noncoding RNA SNHG1 regulates colorectal cancer cell growth through interactions with EZH2 and miR-154-5p. PMID: 30266084 Ref: Baicalin induces apoptosis in SW480 cells through downregulation of the SP1 transcription factor. PMID: 30362980 |