Primary Site >> Liver Cancer

Gene >> SOCS3

Journal: Oncogene. 2005 Sep 22;24(42):6406-17.
Title: Methylation silencing of SOCS-3 promotes cell growth and migration by enhancing JAK/STAT and FAK signalings in human hepatocellular carcinoma.
Author: Niwa, Yasuharu|Kanda, Hiroaki|Shikauchi, Yuko|Saiura, Akio|Matsubara, Kenichi|Kitagawa, Tomoyuki|Yamamoto, Junji|Kubo, Takahiko|Yoshikawa, Hirohide
PMID: 16007195
Journal: Oncogene. 2006 Apr 20;25(17):2520-30.
Title: Loss of SOCS3 in the liver promotes fibrosis by enhancing STAT3-mediated TGF-beta1 production.
Author: Ogata, H|Chinen, T|Yoshida, T|Kinjyo, I|Takaesu, G|Shiraishi, H|Iida, M|Kobayashi, T|Yoshimura, A
PMID: 16474852
Journal: Gastroenterology. 2006 Jul;131(1):179-93.
Title: Deletion of the SOCS3 gene in liver parenchymal cells promotes hepatitis-induced hepatocarcinogenesis.
Author: Ogata, Hisanobu|Kobayashi, Takashi|Chinen, Takatoshi|Takaki, Hiromi|Sanada, Takahito|Minoda, Yasumasa|Koga, Keiko|Takaesu, Giichi|Maehara, Yoshihiko|Iida, Mitsuo|Yoshimura, Akihiko
PMID: 16831601
Journal: Gastroenterology. 2006 Apr;130(4):1117-28.
Title: Ubiquitous activation of Ras and Jak/Stat pathways in human HCC.
Author: Calvisi, Diego F|Ladu, Sara|Gorden, Alexis|Farina, Miriam|Conner, Elizabeth A|Lee, Ju-Seog|Factor, Valentina M|Thorgeirsson, Snorri S
PMID: 16618406
Journal: Oncogene. 2007 Mar 22;26(13):1941-8.
Title: Expression of SOCS1 and SOCS3 genes is differentially regulated in breast cancer cells in response to proinflammatory cytokine and growth factor signals.
Author: Evans, M K|Yu, C-R|Lohani, A|Mahdi, R M|Liu, X|Trzeciak, A R|Egwuagu, C E
PMID: 17001312
Journal: Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2007 Oct;23(10):926-8.
Title: [Study on the role of Wnt/beta-catenin signaling transduction pathway in hepatocellular carcinoma cell line HepG2 and L02 cell line].
Author: Wang, Qi-Ming|Jia, Lian-Qun|Zhou, Hong-Ying|Li, Yun-Sheng
PMID: 17908501
Journal: Hepatology. 2008 Jan;47(1):105-12.
Title: Transfer of suppressor of cytokine signaling 3 by an oncolytic adenovirus induces potential antitumor activities in hepatocellular carcinoma.
Author: Cui, Qiang|Jiang, Wei|Wang, Yingxin|Lv, Chen|Luo, Jingjing|Zhang, Wei|Lin, Fang|Yin, Yuexiang|Cai, Rong|Wei, Ping|Qian, Cheng
PMID: 17935223
Journal: J Exp Med. 2008 Jan 21;205(1):91-103.
Title: Regulation of liver regeneration and hepatocarcinogenesis by suppressor of cytokine signaling 3.
Author: Riehle, Kimberly J|Campbell, Jean S|McMahan, Ryan S|Johnson, Melissa M|Beyer, Richard P|Bammler, Theo K|Fausto, Nelson
PMID: 18158318
Journal: Mol Interv. 2008 Feb;8(1):19-21, 2.
Title: SOCS3 in liver regeneration and hepatocarcinoma.
Author: Elliott, Joanne
PMID: 18332480
Journal: J BUON. 2008 Apr-Jun;13(2):263-5.
Title: Suppressors of cytokine signaling as tumor repressors. Silencing of SOCS3 facilitates tumor formation and growth in lung and liver.
Author: Baltayiannis, G|Baltayiannis, N|Tsianos, E V
PMID: 18555475
Journal: Intervirology. 2008;51(6):432-43.
Title: Subcellular mislocalization of mutant hepatitis B X proteins contributes to modulation of STAT/SOCS signaling in hepatocellular carcinoma.
Author: Bock, C-Thomas|Toan, Nguyen L|Koeberlein, Bernd|Song, Le H|Chin, Ruth|Zentgraf, Hanswalter|Kandolf, Reinhard|Torresi, Joseph
PMID: 19321929
Journal: Clin Chem Lab Med. 2009;47(10):1217-25.
Title: SOCS3 and IRS-1 gene expression differs between genotype 1 and genotype 2 hepatitis C virus-infected HepG2 cells.
Author: Persico, Marcello|Russo, Roberta|Persico, Eliana|Svelto, Monica|Spano, Daniela|Andolfo, Immacolata|La Mura, Vincenzo|Capasso, Mario|Tiribelli, Claudio|Torella, Roberto|Iolascon, Achille
PMID: 19803812
Journal: Hepatology. 2010 Nov;52(5):1713-22.
Title: Adiponectin antagonizes the oncogenic actions of leptin in hepatocellular carcinogenesis.
Author: Sharma, Dipali|Wang, Jason|Fu, Ping P|Sharma, Shvetank|Nagalingam, Arumugam|Mells, Jamie|Handy, Jeffrey|Page, Andrew J|Cohen, Cynthia|Anania, Frank A|Saxena, Neeraj K
PMID: 20941777
Journal: PLoS One. 2010 Mar 23;5(3):e8649.
Title: Hepatitis B virus X protein impairs hepatic insulin signaling through degradation of IRS1 and induction of SOCS3.
Author: Kim, KyeongJin|Kim, Kook Hwan|Cheong, JaeHun
PMID: 20351777
Journal: Acta Biochim Biophys Sin (Shanghai). 2011 Oct;43(10):813-21.
Title: Cancer targeting gene-viro-therapy specific for liver cancer by alpha-fetoprotein-controlled oncolytic adenovirus expression of SOCS3 and IL-24.
Author: Cao, Xin|Wei, Ruicheng|Liu, Xinran|Zeng, Yan|Huang, Hongling|Ding, Miao|Zhang, Kangjian|Liu, Xin-Yuan
PMID: 21835849
Journal: Exp Ther Med. 2011 Jul;2(4):647-653.
Title: Prognostic significance of phosphorylated signal transducer and activator of transcription 3 and suppressor of cytokine signaling 3 expression in hepatocellular carcinoma.
Author: Wu, Wen-Yong|Li, Jun|Wu, Zheng-Sheng|Zhang, Chang-LE|Meng, Xiang-Ling|Lobie, Peter E
PMID: 22977555
Journal: Mol Cell Biochem. 2012 Feb;361(1-2):337-43.
Title: Igf2-derived intronic miR-483 promotes mouse hepatocellular carcinoma cell proliferation.
Author: Ma, Ning|Li, Fuyuan|Li, Dan|Hui, Yang|Wang, Xidi|Qiao, Yu|Zhang, Yanfen|Xiang, Ying|Zhou, Jianying|Zhou, Lingyun|Zheng, Xiaofei|Gao, Xu
PMID: 22052201
Journal: Hepatology. 2012 Sep;56(3):820-30.
Title: Transcriptomic analysis of the woodchuck model of chronic hepatitis B.
Author: Fletcher, Simon P|Chin, Daniel J|Ji, Yongmei|Iniguez, A Leonardo|Taillon, Bruce|Swinney, David C|Ravindran, Palanikumar|Cheng, Donavan T|Bitter, Hans|Lopatin, Uri|Ma, Han|Klumpp, Klaus|Menne, Stephan
PMID: 22431061
Journal: Cell Physiol Biochem. 2012;29(5-6):863-74.
Title: Angiotensin II induces angiogenic factors production partly via AT1/JAK2/STAT3/SOCS3 signaling pathway in MHCC97H cells.
Author: Ji, Yuanyuan|Wang, Zhidong|Li, Zongfang|Li, Ke|Le, Xiaofeng|Zhang, Ting
PMID: 22613986
Journal: World J Gastroenterol. 2013 Feb 14;19(6):866-73.
Title: Interference of suppressor of cytokine signaling 3 promotes epithelial-mesenchymal transition in MHCC97H cells.
Author: Ji, Yuan-Yuan|Wang, Zhi-Dong|Li, Zong-Fang|Li, Ke
PMID: 23430705
Journal: Mol Cell Endocrinol. 2013 Aug 15;375(1-2):68-78.
Title: Pharmacological activation of AMPK suppresses inflammatory response evoked by IL-6 signalling in mouse liver and in human hepatocytes.
Author: Nerstedt, Annika|Cansby, Emmelie|Amrutkar, Manoj|Smith, Ulf|Mahlapuu, Margit
PMID: 23707791
Journal: Am J Physiol Gastrointest Liver Physiol. 2013 Dec;305(11):G829-37.
Title: Mechanisms of STAT3 activation in the liver of FXR knockout mice.
Author: Li, Guodong|Zhu, Yan|Tawfik, Ossama|Kong, Bo|Williams, Jessica A|Zhan, Le|Kassel, Karen M|Luyendyk, James P|Wang, Li|Guo, Grace L
PMID: 24091600
Journal: Oncoimmunology. 2013 Dec 1;2(12):e27090.
Title: Biochemical and functional analyses of gp130 mutants unveil JAK1 as a novel therapeutic target in human inflammatory hepatocellular adenoma.
Author: Poussin, Karine|Pilati, Camilla|Couchy, Gabrielle|Calderaro, Julien|Bioulac-Sage, Paulette|Bacq, Yannick|Paradis, Valerie|Leteurtre, Emmanuelle|Sturm, Nathalie|Ramos, Jeanne|Guettier, Catherine|Bardier-Dupas, Armelle|Boulai, Anais|Wendum, Dominique|Selves
PMID: 24501689
Journal: Front Endocrinol (Lausanne). 2014 Dec 18;5:218.
Title: Evolution of hepatic steatosis to fibrosis and adenoma formation in liver-specific growth hormone receptor knockout mice.
Author: Fan, Yong|Fang, Xin|Tajima, Asako|Geng, Xuehui|Ranganathan, Sarangarajan|Dong, Henry|Trucco, Massimo|Sperling, Mark A
PMID: 25566190
Journal: J Invest Surg. 2014 Aug;27(4):197-204.
Title: Loss of suppressors of cytokine signaling 3 promotes aggressiveness in hepatocellular carcinoma.
Author: Wu, Wen-Yong|Kim, Hyunchul|Zhang, Chang-Le|Meng, Xiang-Ling|Wu, Zheng-Sheng
PMID: 24476004
Journal: Virology. 2014 Aug;462-463:343-50.
Title: MiR-221 accentuates IFNs anti-HCV effect by downregulating SOCS1 and SOCS3.
Author: Xu, Gang|Yang, Fang|Ding, Cui-Ling|Wang, Jing|Zhao, Ping|Wang, Wen|Ren, Hao
PMID: 25019494
Journal: Cell Cycle. 2015;14(7):1090-102.
Title: In vitro and in vivo conditional sensitization of hepatocellular carcinoma cells to TNF-induced apoptosis by taxol.
Author: Minero, V G|De Stefanis, D|Costelli, P|Baccino, F M|Bonelli, G
PMID: 25564714
Journal: Antiviral Res. 2015 Jun;118:20-8.
Title: Down-regulation of suppressor of cytokine signaling 3 by miR-122 enhances interferon-mediated suppression of hepatitis B virus.
Author: Gao, Dongni|Zhai, Aixia|Qian, Jun|Li, Aimei|Li, Yujun|Song, Wuqi|Zhao, Hong|Yu, Xin|Wu, Jing|Zhang, Qingmeng|Kao, Wenping|Wei, Lanlan|Zhang, Fengmin|Zhong, Zhaohua
PMID: 25766860
Journal: Int J Mol Sci. 2015 Sep 18;16(9):22662-75.
Title: SOCS3 Methylation Predicts a Poor Prognosis in HBV Infection-Related Hepatocellular Carcinoma.
Author: Zhang, Xin|You, Qingshan|Zhang, Xiaolei|Chen, Xiangmei
PMID: 26393582
Journal: Oncotarget. 2015 Oct 27;6(33):34606-16.
Title: FXR induces SOCS3 and suppresses hepatocellular carcinoma.
Author: Guo, Fei|Xu, Zhizhen|Zhang, Yan|Jiang, Peng|Huang, Gang|Chen, Shan|Lyu, Xilin|Zheng, Ping|Zhao, Xin|Zeng, Yijun|Wang, Shuguang|He, Fengtian
PMID: 26416445
Journal: Medicine (Baltimore). 2015 Oct;94(40):e1344.
Title: SOCS3 Genetic Polymorphism Is Associated With Clinical Features and Prognosis of Hepatocellular Carcinoma Patients Receiving Hepatectomy.
Author: Jiang, Bei-ge|Yang, Yuan|Liu, Hui|Gu, Fang-ming|Yang, Yun|Zhao, Lin-Hao|Yuan, Sheng-xian|Wang, Ruo-yu|Zhang, Jin|Zhou, Wei-ping
PMID: 26447993
Journal: PLoS One. 2016 Mar 16;11(3):e0151455.
Title: Estradiol and Estrogen Receptor Agonists Oppose Oncogenic Actions of Leptin in HepG2 Cells.
Author: Shen, Minqian|Shi, Haifei
PMID: 26982332
Journal: Biomed Pharmacother. 2016 Aug;82:72-9.
Title: Artesunate obliterates experimental hepatocellular carcinoma in rats through suppression of IL-6-JAK-STAT signalling.
Author: Ilamathi, M|Prabu, P C|Ayyappa, K Ashok|Sivaramakrishnan, V
PMID: 27470341
Journal: Genet Test Mol Biomarkers. 2016 Sep;20(9):535-43.
Title: Risk Factors for Hepatocellular Carcinoma in Cirrhotic Patients with Chronic Hepatitis B.
Author: Zhang, Yuan-Qing|Peng, Li-Jun|Cao, Yi-Rong|Zeng, Zhi-Ping|Wu, Yu-Jing|Shi, Hong|Cheng, Shi-Yao|Wang, Ji-Yao|Friedman, Scott L|Sninsky, John J|Guo, Jin-Sheng
PMID: 27391584
Journal: Cell. 2016 May 5;165(4):896-909.
Title: Lung Adenocarcinoma Distally Rewires Hepatic Circadian Homeostasis.
Author: Masri, Selma|Papagiannakopoulos, Thales|Kinouchi, Kenichiro|Liu, Yu|Cervantes, Marlene|Baldi, Pierre|Jacks, Tyler|Sassone-Corsi, Paolo
PMID: 27153497
Journal: Cell Death Differ. 2016 Apr;23(4):616-27.
Title: HBV-induced ROS accumulation promotes hepatocarcinogenesis through Snail-mediated epigenetic silencing of SOCS3.
Author: Yuan, K|Lei, Y|Chen, H-N|Chen, Y|Zhang, T|Li, K|Xie, N|Wang, K|Feng, X|Pu, Q|Yang, W|Wu, M|Xiang, R|Nice, E C|Wei, Y|Huang, C
PMID: 26794444
Journal: Biochim Biophys Acta Mol Cell Res. 2017 Mar;1864(3):516-526.
Title: Crosstalk between different family members: IL27 recapitulates IFNgamma responses in HCC cells, but is inhibited by IL6-type cytokines.
Author: Rolvering, Catherine|Zimmer, Andreas D|Kozar, Ines|Hermanns, Heike M|Letellier, Elisabeth|Vallar, Laurent|Nazarov, Petr V|Nicot, Nathalie|Ginolhac, Aurelien|Haan, Serge|Behrmann, Iris|Haan, Claude
PMID: 27939431
Journal: Toxicol Appl Pharmacol. 2017 Dec 1;336:31-39.
Title: 6-Hydroxy-3-O-methyl-kaempferol 6-O-glucopyranoside potentiates the anti-proliferative effect of interferon alpha/beta by promoting activation of the JAK/STAT signaling by inhibiting SOCS3 in hepatocellular carcinoma cells.
Author: Wonganan, Orawan|He, Yu-Jiao|Shen, Xiao-Fei|Wongkrajang, Kanjana|Suksamrarn, Apichart|Zhang, Guo-Lin|Wang, Fei
PMID: 29031523
Journal: Oncotarget. 2017 Jul 18;8(38):64083-64094.
Title: Induction of SOCS3 by liver X receptor suppresses the proliferation of hepatocellular carcinoma cells.
Author: Xiong, Haojun|Zhang, Yan|Chen, Shan|Ni, Zhenhong|He, Jintao|Li, Xinzhe|Li, Bo|Zhao, Kai|Yang, Fan|Zeng, Yijun|Chen, Bingbo|He, Fengtian
PMID: 28969053
Journal: J Surg Res. 2017 May 1;211:53-63.
Title: MicroRNA-203 promotes liver regeneration after partial hepatectomy in cirrhotic rats.
Author: Chen, Xiao-Bo|Zheng, Xiao-Bo|Cai, Zhen-Xing|Lin, Xian-Jian|Xu, Ming-Qing
PMID: 28501131
Journal: Oncotarget. 2017 Apr 25;8(17):28621-28627.
Title: Tumor SOCS3 methylation status predicts the treatment response to TACE and prognosis in HCC patients.
Author: Jiang, Bei-Ge|Wang, Neng|Huang, Jian|Yang, Yuan|Sun, Liang-Liang|Pan, Ze-Ya|Zhou, Wei-Ping
PMID: 28404963
Journal: Medicine (Baltimore). 2017 Mar;96(12):e6420.
Title: The prognostic role of BORIS and SOCS3 in human hepatocellular carcinoma.
Author: Zhao, Rongce|Chen, Kefei|Zhou, Jing|He, Jingyang|Liu, Jun|Guan, Peng|Li, Bo|Qin, Yang
PMID: 28328845
Journal: Oncotarget. 2017 Mar 7;8(10):17127-17139.
Title: SOCS3 genetic variants and promoter hypermethylation in patients with chronic hepatitis B.
Author: Hoan, Nghiem Xuan|Van Tong, Hoang|Giang, Dao Phuong|Cuong, Bui Khac|Toan, Nguyen Linh|Wedemeyer, Heiner|Bock, C Thomas|Kremsner, Peter G|Song, Le Huu|Velavan, Thirumalaisamy P
PMID: 28179578
Journal: Cancer Sci. 2017 Mar;108(3):338-346.
Title: miR-203 inhibits augmented proliferation and metastasis of hepatocellular carcinoma residual in the promoted regenerating liver.
Author: Zheng, Xiao-Bo|Chen, Xiao-Bo|Xu, Liang-Liang|Zhang, Ming|Feng, Lei|Yi, Peng-Sheng|Tang, Jian-Wei|Xu, Ming-Qing
PMID: 28100026
Journal: J Med Virol. 2017 Feb;89(2):267-275.
Title: Hepatitis B virus X protein impairs alpha-interferon signaling via up-regulation of suppressor of cytokine signaling 3 and protein phosphatase 2A.
Author: Tsunematsu, Seiji|Suda, Goki|Yamasaki, Kazushi|Kimura, Megumi|Izumi, Takaaki|Umemura, Machiko|Ito, Jun|Sato, Fumiyuki|Nakai, Masato|Sho, Takuya|Morikawa, Kenichi|Ogawa, Koji|Tanaka, Yasuhito|Watashi, Koichi|Wakita, Takaji|Sakamoto, Naoya
PMID: 27459003
Journal: Clin Exp Med. 2018 Feb;18(1):79-87.
Title: Detection of promoter methylation status of suppressor of cytokine signaling 3 (SOCS3) in tissue and plasma from Chinese patients with different hepatic diseases.
Author: Wei, Ling|Huang, Yuan|Zhao, Rongce|Zhang, Jing|Liu, Qiuying|Liang, Weibo|Ding, Xueqin|Gao, Bo|Li, Bo|Sun, Chengjun|He, Jingyang|Yu, Xiaoqin|Liu, Zhongjian|Sun, Aimin|Qin, Yang
PMID: 28951980
Journal: Asian Pac J Cancer Prev. 2018 Feb 26;19(2):387-393.
Title: Ellagic Acid Holds Promise Against Hepatocellular Carcinoma in an Experimental Model: Mechanisms of Action
Author: Zaazaa, Asmaa M|Lokman, Maha S|Shalby, Aziza B|Ahmed, Hanaa H|El-Toumy, Sayed A
PMID: 29479987
Journal: Sichuan Da Xue Xue Bao Yi Xue Ban. 2018 Jan;49(1):1-7.
Title: [BORIS Regulates SOCS3 Expression Through Epigenetic Mechanisms in Human Hepatocellular Carcinoma Cells].
Author: He, Jing-Yang|Liu, Qiu-Ying|Wei, Ling|Liu, Zhong-Jian|Huang, Yuan|Yu, Xiao-Qin|Li, Bo|Qin, Yang
PMID: 29737080
Journal: Infect Genet Evol. 2018 Aug 30;66:1-8.
Title: Control of progression towards liver fibrosis and hepatocellular carcinoma by SOCS3 polymorphisms in chronic HCV-infected patients.
Author: Jadid, Fatima Zahra|Chihab, Hajar|Alj, Hanane Salih|Elfihry, Raouia|Zaidane, Imane|Tazi, Sanaa|Badre, Wafaa|Marchio, Agnes|El Filali, Kamal Marhoum|Tahiri, Mohammed|Saile, Rachid|Pineau, Pascal|Ezzikouri, Sayeh|Benjelloun, Soumaya
PMID: 30172885
Journal: J Cell Physiol. 2018 Oct 28.
Title: In vivo and in vitro effects of microRNA-221 on hepatocellular carcinoma development and progression through the JAK-STAT3 signaling pathway by targeting SOCS3.
Author: Huang, Shan|Zhou, Da|Li, Yu-Xuan|Ming, Zhi-Yong|Li, Ke-Zhi|Wu, Guo-Bin|Chen, Chuang|Zhao, Yin-Nong
PMID: 30370582
Journal: Clin Res Hepatol Gastroenterol. 2018 Oct 29. pii: S2210-7401(18)30215-8.
Title: Expression and prognostic value of HER-2/neu, STAT3 and SOCS3 in hepatocellular carcinoma.
Author: Jiang, Li-Hua|Hao, Ying-Li|Zhu, Jing-Wei
PMID: 30385249