Primary Site >> Liver Cancer
Gene >> SOCS3
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Ref: Methylation silencing of SOCS-3 promotes cell growth and migration by enhancing JAK/STAT and FAK signalings in human hepatocellular carcinoma. PMID: 16007195 |
Ref: Loss of SOCS3 in the liver promotes fibrosis by enhancing STAT3-mediated TGF-beta1 production. PMID: 16474852 Ref: Ubiquitous activation of Ras and Jak/Stat pathways in human HCC. PMID: 16618406 Ref: Deletion of the SOCS3 gene in liver parenchymal cells promotes hepatitis-induced hepatocarcinogenesis. PMID: 16831601 |
Ref: Expression of SOCS1 and SOCS3 genes is differentially regulated in breast cancer cells in response to proinflammatory cytokine and growth factor signals. PMID: 17001312 Ref: [Study on the role of Wnt/beta-catenin signaling transduction pathway in hepatocellular carcinoma cell line HepG2 and L02 cell line]. PMID: 17908501 |
Ref: Transfer of suppressor of cytokine signaling 3 by an oncolytic adenovirus induces potential antitumor activities in hepatocellular carcinoma. PMID: 17935223 Ref: Regulation of liver regeneration and hepatocarcinogenesis by suppressor of cytokine signaling 3. PMID: 18158318 Ref: SOCS3 in liver regeneration and hepatocarcinoma. PMID: 18332480 Ref: Suppressors of cytokine signaling as tumor repressors. Silencing of SOCS3 facilitates tumor formation and growth in lung and liver. PMID: 18555475 Ref: Subcellular mislocalization of mutant hepatitis B X proteins contributes to modulation of STAT/SOCS signaling in hepatocellular carcinoma. PMID: 19321929 |
Ref: SOCS3 and IRS-1 gene expression differs between genotype 1 and genotype 2 hepatitis C virus-infected HepG2 cells. PMID: 19803812 |
Ref: Hepatitis B virus X protein impairs hepatic insulin signaling through degradation of IRS1 and induction of SOCS3. PMID: 20351777 Ref: Adiponectin antagonizes the oncogenic actions of leptin in hepatocellular carcinogenesis. PMID: 20941777 |
Ref: Cancer targeting gene-viro-therapy specific for liver cancer by alpha-fetoprotein-controlled oncolytic adenovirus expression of SOCS3 and IL-24. PMID: 21835849 Ref: Prognostic significance of phosphorylated signal transducer and activator of transcription 3 and suppressor of cytokine signaling 3 expression in hepatocellular carcinoma. PMID: 22977555 |
Ref: Igf2-derived intronic miR-483 promotes mouse hepatocellular carcinoma cell proliferation. PMID: 22052201 Ref: Transcriptomic analysis of the woodchuck model of chronic hepatitis B. PMID: 22431061 Ref: Angiotensin II induces angiogenic factors production partly via AT1/JAK2/STAT3/SOCS3 signaling pathway in MHCC97H cells. PMID: 22613986 |
Ref: Interference of suppressor of cytokine signaling 3 promotes epithelial-mesenchymal transition in MHCC97H cells. PMID: 23430705 Ref: Pharmacological activation of AMPK suppresses inflammatory response evoked by IL-6 signalling in mouse liver and in human hepatocytes. PMID: 23707791 Ref: Mechanisms of STAT3 activation in the liver of FXR knockout mice. PMID: 24091600 Ref: Biochemical and functional analyses of gp130 mutants unveil JAK1 as a novel therapeutic target in human inflammatory hepatocellular adenoma. PMID: 24501689 |
Ref: Loss of suppressors of cytokine signaling 3 promotes aggressiveness in hepatocellular carcinoma. PMID: 24476004 Ref: MiR-221 accentuates IFNs anti-HCV effect by downregulating SOCS1 and SOCS3. PMID: 25019494 Ref: Evolution of hepatic steatosis to fibrosis and adenoma formation in liver-specific growth hormone receptor knockout mice. PMID: 25566190 |
Ref: In vitro and in vivo conditional sensitization of hepatocellular carcinoma cells to TNF-induced apoptosis by taxol. PMID: 25564714 Ref: Down-regulation of suppressor of cytokine signaling 3 by miR-122 enhances interferon-mediated suppression of hepatitis B virus. PMID: 25766860 Ref: SOCS3 Methylation Predicts a Poor Prognosis in HBV Infection-Related Hepatocellular Carcinoma. PMID: 26393582 Ref: FXR induces SOCS3 and suppresses hepatocellular carcinoma. PMID: 26416445 Ref: SOCS3 Genetic Polymorphism Is Associated With Clinical Features and Prognosis of Hepatocellular Carcinoma Patients Receiving Hepatectomy. PMID: 26447993 |
Ref: HBV-induced ROS accumulation promotes hepatocarcinogenesis through Snail-mediated epigenetic silencing of SOCS3. PMID: 26794444 Ref: Estradiol and Estrogen Receptor Agonists Oppose Oncogenic Actions of Leptin in HepG2 Cells. PMID: 26982332 Ref: Lung Adenocarcinoma Distally Rewires Hepatic Circadian Homeostasis. PMID: 27153497 Ref: Risk Factors for Hepatocellular Carcinoma in Cirrhotic Patients with Chronic Hepatitis B. PMID: 27391584 Ref: Artesunate obliterates experimental hepatocellular carcinoma in rats through suppression of IL-6-JAK-STAT signalling. PMID: 27470341 |
Ref: Hepatitis B virus X protein impairs alpha-interferon signaling via up-regulation of suppressor of cytokine signaling 3 and protein phosphatase 2A. PMID: 27459003 Ref: Crosstalk between different family members: IL27 recapitulates IFNgamma responses in HCC cells, but is inhibited by IL6-type cytokines. PMID: 27939431 Ref: miR-203 inhibits augmented proliferation and metastasis of hepatocellular carcinoma residual in the promoted regenerating liver. PMID: 28100026 Ref: SOCS3 genetic variants and promoter hypermethylation in patients with chronic hepatitis B. PMID: 28179578 Ref: The prognostic role of BORIS and SOCS3 in human hepatocellular carcinoma. PMID: 28328845 Ref: Tumor SOCS3 methylation status predicts the treatment response to TACE and prognosis in HCC patients. PMID: 28404963 Ref: MicroRNA-203 promotes liver regeneration after partial hepatectomy in cirrhotic rats. PMID: 28501131 Ref: Induction of SOCS3 by liver X receptor suppresses the proliferation of hepatocellular carcinoma cells. PMID: 28969053 Ref: 6-Hydroxy-3-O-methyl-kaempferol 6-O-glucopyranoside potentiates the anti-proliferative effect of interferon alpha/beta by promoting activation of the JAK/STAT signaling by inhibiting SOCS3 in hepatocellular carcinoma cells. PMID: 29031523 |
Ref: Detection of promoter methylation status of suppressor of cytokine signaling 3 (SOCS3) in tissue and plasma from Chinese patients with different hepatic diseases. PMID: 28951980 Ref: Ellagic Acid Holds Promise Against Hepatocellular Carcinoma in an Experimental Model: Mechanisms of Action PMID: 29479987 Ref: [BORIS Regulates SOCS3 Expression Through Epigenetic Mechanisms in Human Hepatocellular Carcinoma Cells]. PMID: 29737080 Ref: Control of progression towards liver fibrosis and hepatocellular carcinoma by SOCS3 polymorphisms in chronic HCV-infected patients. PMID: 30172885 Ref: In vivo and in vitro effects of microRNA-221 on hepatocellular carcinoma development and progression through the JAK-STAT3 signaling pathway by targeting SOCS3. PMID: 30370582 Ref: Expression and prognostic value of HER-2/neu, STAT3 and SOCS3 in hepatocellular carcinoma. PMID: 30385249 |