Primary Site >> Colorectal Cancer

Gene >> SOCS3

Journal: Mol Cancer Ther. 2007 Aug;6(8):2158-67. Epub 2007 Aug 1.
Title: A novel, potent, and selective insulin-like growth factor-I receptor kinase inhibitor blocks insulin-like growth factor-I receptor signaling in vitro and inhibits insulin-like growth factor-I receptor dependent tumor growth in vivo.
Author: Ji, Qun-sheng|Mulvihill, Mark J|Rosenfeld-Franklin, Maryland|Cooke, Andrew|Feng, Lixin|Mak, Gilda|O'Connor, Matthew|Yao, Yan|Pirritt, Caroline|Buck, Elizabeth|Eyzaguirre, Alexandra|Arnold, Lee D|Gibson, Neil W|Pachter, Jonathan A
PMID: 17671083
Journal: Oncogene. 2007 Jul 19;26(33):4833-41. Epub 2007 Feb 12.
Title: Suppressor of cytokine signaling 3 (SOCS3) limits damage-induced crypt hyper-proliferation and inflammation-associated tumorigenesis in the colon.
Author: Rigby, R J|Simmons, J G|Greenhalgh, C J|Alexander, W S|Lund, P K
PMID: 17297444
Journal: Cancer Sci. 2008 Aug;99(8):1650-5.
Title: Enhancement of antiproliferative activity of interferons by RNA interference-mediated silencing of SOCS gene expression in tumor cells.
Author: Takahashi, Yuki|Kaneda, Haruka|Takasuka, Nana|Hattori, Kayoko|Nishikawa, Makiya|Watanabe, Yoshihiko|Takakura, Yoshinobu
PMID: 18754879
Journal: J Interferon Cytokine Res. 2009 Dec;29(12):809-16.
Title: Defective interleukin-4/Stat6 activity correlates with increased constitutive expression of negative regulators SOCS-3, SOCS-7, and CISH in colon cancer cells.
Author: Liu, Xiao Hong|Xu, Shuang Bing|Yuan, Jia|Li, Ben Hui|Zhang, Yan|Yuan, Qin|Li, Pin Dong|Li, Feng|Zhang, Wen Jie
PMID: 19929568
Journal: J Cell Mol Med. 2009 Sep;13(9B):3668-79.
Title: Inhibition of DNA methyltransferase induces G2 cell cycle arrest and apoptosis in human colorectal cancer cells via inhibition of JAK2/STAT3/STAT5 signalling.
Author: Xiong, Hua|Chen, Zhao-Fei|Liang, Qin-Chuan|Du, Wan|Chen, Hui-Min|Su, Wen-Yu|Chen, Guo-Qiang|Han, Ze-Guang|Fang, Jing-Yuan
PMID: 20196786
Journal: Gut. 2010 Feb;59(2):227-35.
Title: Disease-related expression of the IL6/STAT3/SOCS3 signalling pathway in ulcerative colitis and ulcerative colitis-related carcinogenesis.
Author: Li, Yi|de Haar, Colin|Chen, Min|Deuring, Jasper|Gerrits, Monique M|Smits, Ron|Xia, Bing|Kuipers, Ernst J|van der Woude, C Janneke
PMID: 19926618
Journal: BMC Res Notes. 2010 May 25;3:144.
Title: Suppressor of cytokine signaling 3 (SOCS3) is not an independent biomarker of colorectal adenoma risk.
Author: Hamilton, Kathryn E|Lund, P Kay|Galanko, Joseph A|Sandler, Robert S|Keku, Temitope O
PMID: 20500855
Journal: PLoS One. 2011;6(7):e22538.
Title: STAT3 activation in skeletal muscle links muscle wasting and the acute phase response in cancer cachexia.
Author: Bonetto, Andrea|Aydogdu, Tufan|Kunzevitzky, Noelia|Guttridge, Denis C|Khuri, Sawsan|Koniaris, Leonidas G|Zimmers, Teresa A
PMID: 21799891
Journal: Mol Cancer Res. 2011 Dec;9(12):1718-31.
Title: Cytokine induction of tumor necrosis factor receptor 2 is mediated by STAT3 in colon cancer cells.
Author: Hamilton, Kathryn E|Simmons, James G|Ding, Shengli|Van Landeghem, Laurianne|Lund, P Kay
PMID: 21994466
Journal: Mol Carcinog. 2012 Feb;51(2):174-84.
Title: Trichostatin A, a histone deacetylase inhibitor, suppresses JAK2/STAT3 signaling via inducing the promoter-associated histone acetylation of SOCS1 and SOCS3 in human colorectal cancer cells.
Author: Xiong, Hua|Du, Wan|Zhang, Yan-Jie|Hong, Jie|Su, Wen-Yu|Tang, Jie-Ting|Wang, Ying-Chao|Lu, Rong|Fang, Jing-Yuan
PMID: 21520296
Journal: Aging (Albany NY). 2012 Feb;4(2):133-43.
Title: Disruption of MEF2C signaling and loss of sarcomeric and mitochondrial integrity in cancer-induced skeletal muscle wasting.
Author: Shum, Angie M Y|Mahendradatta, Theodore|Taylor, Ryland J|Painter, Arran B|Moore, Melissa M|Tsoli, Maria|Tan, Timothy C|Clarke, Stephen J|Robertson, Graham R|Polly, Patsie
PMID: 22361433
Journal: Carcinogenesis. 2012 Oct;33(10):1889-96.
Title: IL-6-induced DNMT1 activity mediates SOCS3 promoter hypermethylation in ulcerative colitis-related colorectal cancer.
Author: Li, Yi|Deuring, Jasper|Peppelenbosch, Maikel P|Kuipers, Ernst J|de Haar, Colin|van der Woude, C Janneke
PMID: 22739025
Journal: Oncol Rep. 2012 Dec;28(6):2125-30.
Title: Pien Tze Huang suppresses IL-6-inducible STAT3 activation in human colon carcinoma cells through induction of SOCS3.
Author: Shen, Aling|Chen, Youqin|Hong, Fei|Lin, Jiumao|Wei, Lihui|Hong, Zhenfeng|Sferra, Thomas J|Peng, Jun
PMID: 23027374
Journal: Genet Test Mol Biomarkers. 2012 Dec;16(12):1395-400.
Title: Mutational screening of the SOCS3 gene promoter in metastatic colorectal cancer patients.
Author: Igci, Mehri|Cakmak, Ecir Ali|Oztuzcu, Serdar|Bayram, Ali|Arslan, Ahmet|Gogebakan, Bulent|Igci, Yusuf Ziya|Cengiz, Beyhan|Ozkara, Esma|Camci, Celaletdin|Demiryurek, A Tuncay
PMID: 23046072
Journal: Scand J Clin Lab Invest. 2012 Dec;72(8):593-601.
Title: Human monocyte responses to lipopolysaccharide and 9-cis retinoic acid after laparoscopic surgery for colon cancer.
Author: Kolseth, Ingrid B M|Forland, Dag T|Risoe, Petter K|Flood-Kjeldsen, Signe|Agren, Joanna|Reseland, Janne E|Lyngstadaas, Staale P|Johnson, Egil|Dahle, Maria K
PMID: 23094762
Journal: PLoS One. 2013 Oct 3;8(10):e74140.
Title: Sporadic colorectal cancer development shows rejuvenescence regarding epithelial proliferation and apoptosis.
Author: Leiszter, Katalin|Galamb, Orsolya|Sipos, Ferenc|Krenacs, Tibor|Veres, Gabor|Wichmann, Barnabas|Kalmar, Alexandra|Patai, Arpad V|Toth, Kinga|Valcz, Gabor|Molnar, Bela|Tulassay, Zsolt
PMID: 24098334
Journal: Oncol Rep. 2014 Jan;31(1):335-41.
Title: Activation of the JAK-STAT3 pathway is associated with the growth of colorectal carcinoma cells.
Author: Wei, Xubin|Wang, Gang|Li, Wei|Hu, Xupang|Huang, Qinghong|Xu, Ke|Lou, Wenjia|Wu, Jia|Liang, Chen|Lou, Qibin|Qian, Chen|Liu, Li
PMID: 24253664
Journal: Carcinogenesis. 2014 Jun;35(6):1330-40.
Title: IL-23 selectively promotes the metastasis of colorectal carcinoma cells with impaired Socs3 expression via the STAT5 pathway.
Author: Zhang, Le|Li, Jun|Li, Li|Zhang, Jie|Wang, Xiaodong|Yang, Chuanhua|Li, Yanyan|Lan, Feng|Lin, Ping
PMID: 24464786
Journal: PLoS One. 2014 Mar 25;9(3):e92966.
Title: Depletion of white adipose tissue in cancer cachexia syndrome is associated with inflammatory signaling and disrupted circadian regulation.
Author: Tsoli, Maria|Schweiger, Martina|Vanniasinghe, Anne S|Painter, Arran|Zechner, Rudolf|Clarke, Stephen|Robertson, Graham
PMID: 24667661
Journal: World J Surg. 2015 Nov;39(11):2776-83.
Title: A Four-Probiotics Regimen Reduces Postoperative Complications After Colorectal Surgery: A Randomized, Double-Blind, Placebo-Controlled Study.
Author: Kotzampassi, Katerina|Stavrou, George|Damoraki, Georgia|Georgitsi, Marianna|Basdanis, George|Tsaousi, Georgia|Giamarellos-Bourboulis, Evangelos J
PMID: 25894405
Journal: BMC Cancer. 2015 Oct 19;15:736.
Title: DNA hypermethylation and decreased mRNA expression of MAL, PRIMA1, PTGDR and SFRP1 in colorectal adenoma and cancer.
Author: Kalmar, Alexandra|Peterfia, Balint|Hollosi, Peter|Galamb, Orsolya|Spisak, Sandor|Wichmann, Barnabas|Bodor, Andras|Toth, Kinga|Patai, Arpad V|Valcz, Gabor|Nagy, Zsofia Brigitta|Kubak, Vivien|Tulassay, Zsolt|Kovalszky, Ilona|Molnar, Bela
PMID: 26482433
Journal: Int J Clin Exp Med. 2015 Aug 15;8(8):12009-17. eCollection 2015.
Title: IL-6/STAT3/SOCS3 signaling pathway playing a regulatory role in ulcerative colitis carcinogenesis.
Author: Chen, Ying-Ying|Ma, Zhi-Bin|Xu, Hong-Yu|Shi, Li-Jun|Li, Dong-Yue|Sun, Li-Ying|Yin, Xun-Hai|Sang, Guo-Yin|Xu, Dan|Tang, Yin-Hua|Wang, Xi|Li, Peng|Wu, Feng|Zhou, Jin
PMID: 26550113
Journal: Mol Carcinog. 2016 May;55(5):600-10.
Title: Antagonizing pathways leading to differential dynamics in colon carcinogenesis in Shugoshin1 (Sgo1)-haploinsufficient chromosome instability model.
Author: Rao, Chinthalapally V|Sanghera, Saira|Zhang, Yuting|Biddick, Laura|Reddy, Arun|Lightfoot, Stan|Dai, Wei|Yamada, Hiroshi Y
PMID: 25773652
Journal: Tumour Biol. 2016 Jul;37(7):8841-8.
Title: Investigation of FIH-1 and SOCS3 expression in KRAS mutant and wild-type patients with colorectal cancer.
Author: Vakil, Ladan|Najafipour, Reza|Rakhshani, Nasser|Zamani, Farhad|Morakabati, Arman|Javadi, Amir
PMID: 26749281
Journal: PLoS One. 2016 May 12;11(5):e0155660.
Title: Systematic Analysis of Gene Expression Alterations and Clinical Outcomes for Long-Chain Acyl-Coenzyme A Synthetase Family in Cancer.
Author: Chen, Wei-Ching|Wang, Chih-Yang|Hung, Yu-Hsuan|Weng, Tzu-Yang|Yen, Meng-Chi|Lai, Ming-Derg
PMID: 27171439
Journal: Biofactors. 2017 Mar;43(2):283-292.
Title: Cooperation between the bacterial-derived short-chain fatty acid butyrate and interleukin-22 detected in human Caco2 colon epithelial/carcinoma cells.
Author: Bachmann, Malte|Meissner, Carlotta|Pfeilschifter, Josef|Muhl, Heiko
PMID: 27801948
Journal: FEBS Lett. 2017 May;591(10):1371-1382.
Title: Resistin causes G1 arrest in colon cancer cells through upregulation of SOCS3.
Author: Singh, Snahlata|Chouhan, Surbhi|Mohammad, Naoshad|Bhat, Manoj Kumar
PMID: 28417458
Journal: Oncotarget. 2017 Jul 25;8(30):49807-49823.
Title: Maintenance of cancer stemness by miR-196b-5p contributes to chemoresistance of colorectal cancer cells via activating STAT3 signaling pathway.
Author: Ren, Dong|Lin, Bihua|Zhang, Xin|Peng, Yao|Ye, Ziyu|Ma, Yan|Liang, Yangfang|Cao, Longbin|Li, Xiangyong|Li, Ronggang|Sun, Lixia|Liu, Qiongru|Wu, Jinhua|Zhou, Keyuan|Zeng, Jincheng
PMID: 28591704
Journal: Gene. 2017 Sep 5;627:114-122.
Title: Prognostic significance of SOCS3 and its biological function in colorectal cancer.
Author: Chu, Qinjun|Shen, Dan|He, Long|Wang, Hongwei|Liu, Chunlan|Zhang, Wei
PMID: 28603075
Journal: Oncotarget. 2017 Dec 20;9(22):15984-15996.
Title: The role and gene expression profile of SOCS3 in colorectal carcinoma.
Author: Dong, Xing|Wang, Jing|Tang, Bo|Hao, Yeng-Xue|Li, Ping-Yang|Li, Shi-Yong|Yu, Pei-Wu
PMID: 29662621