Primary Site >> Colorectal Cancer
Gene >> SOCS3
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Ref: Suppressor of cytokine signaling 3 (SOCS3) limits damage-induced crypt hyper-proliferation and inflammation-associated tumorigenesis in the colon. PMID: 17297444 Ref: A novel, potent, and selective insulin-like growth factor-I receptor kinase inhibitor blocks insulin-like growth factor-I receptor signaling in vitro and inhibits insulin-like growth factor-I receptor dependent tumor growth in vivo. PMID: 17671083 |
Ref: Enhancement of antiproliferative activity of interferons by RNA interference-mediated silencing of SOCS gene expression in tumor cells. PMID: 18754879 |
Ref: Defective interleukin-4/Stat6 activity correlates with increased constitutive expression of negative regulators SOCS-3, SOCS-7, and CISH in colon cancer cells. PMID: 19929568 Ref: Inhibition of DNA methyltransferase induces G2 cell cycle arrest and apoptosis in human colorectal cancer cells via inhibition of JAK2/STAT3/STAT5 signalling. PMID: 20196786 |
Ref: Disease-related expression of the IL6/STAT3/SOCS3 signalling pathway in ulcerative colitis and ulcerative colitis-related carcinogenesis. PMID: 19926618 Ref: Suppressor of cytokine signaling 3 (SOCS3) is not an independent biomarker of colorectal adenoma risk. PMID: 20500855 |
Ref: STAT3 activation in skeletal muscle links muscle wasting and the acute phase response in cancer cachexia. PMID: 21799891 Ref: Cytokine induction of tumor necrosis factor receptor 2 is mediated by STAT3 in colon cancer cells. PMID: 21994466 |
Ref: Trichostatin A, a histone deacetylase inhibitor, suppresses JAK2/STAT3 signaling via inducing the promoter-associated histone acetylation of SOCS1 and SOCS3 in human colorectal cancer cells. PMID: 21520296 Ref: Disruption of MEF2C signaling and loss of sarcomeric and mitochondrial integrity in cancer-induced skeletal muscle wasting. PMID: 22361433 Ref: IL-6-induced DNMT1 activity mediates SOCS3 promoter hypermethylation in ulcerative colitis-related colorectal cancer. PMID: 22739025 Ref: Pien Tze Huang suppresses IL-6-inducible STAT3 activation in human colon carcinoma cells through induction of SOCS3. PMID: 23027374 Ref: Mutational screening of the SOCS3 gene promoter in metastatic colorectal cancer patients. PMID: 23046072 Ref: Human monocyte responses to lipopolysaccharide and 9-cis retinoic acid after laparoscopic surgery for colon cancer. PMID: 23094762 |
Ref: Sporadic colorectal cancer development shows rejuvenescence regarding epithelial proliferation and apoptosis. PMID: 24098334 |
Ref: Activation of the JAK-STAT3 pathway is associated with the growth of colorectal carcinoma cells. PMID: 24253664 Ref: IL-23 selectively promotes the metastasis of colorectal carcinoma cells with impaired Socs3 expression via the STAT5 pathway. PMID: 24464786 Ref: Depletion of white adipose tissue in cancer cachexia syndrome is associated with inflammatory signaling and disrupted circadian regulation. PMID: 24667661 |
Ref: A Four-Probiotics Regimen Reduces Postoperative Complications After Colorectal Surgery: A Randomized, Double-Blind, Placebo-Controlled Study. PMID: 25894405 Ref: DNA hypermethylation and decreased mRNA expression of MAL, PRIMA1, PTGDR and SFRP1 in colorectal adenoma and cancer. PMID: 26482433 Ref: IL-6/STAT3/SOCS3 signaling pathway playing a regulatory role in ulcerative colitis carcinogenesis. PMID: 26550113 |
Ref: Antagonizing pathways leading to differential dynamics in colon carcinogenesis in Shugoshin1 (Sgo1)-haploinsufficient chromosome instability model. PMID: 25773652 Ref: Investigation of FIH-1 and SOCS3 expression in KRAS mutant and wild-type patients with colorectal cancer. PMID: 26749281 Ref: Systematic Analysis of Gene Expression Alterations and Clinical Outcomes for Long-Chain Acyl-Coenzyme A Synthetase Family in Cancer. PMID: 27171439 |
Ref: Cooperation between the bacterial-derived short-chain fatty acid butyrate and interleukin-22 detected in human Caco2 colon epithelial/carcinoma cells. PMID: 27801948 Ref: Resistin causes G1 arrest in colon cancer cells through upregulation of SOCS3. PMID: 28417458 Ref: Maintenance of cancer stemness by miR-196b-5p contributes to chemoresistance of colorectal cancer cells via activating STAT3 signaling pathway. PMID: 28591704 Ref: Prognostic significance of SOCS3 and its biological function in colorectal cancer. PMID: 28603075 |
Ref: The role and gene expression profile of SOCS3 in colorectal carcinoma. PMID: 29662621 |