Primary Site >> Pancreatic Cancer
Gene >> SMO
| 1. | |||||||||||
| Journal: | Int J Oncol. 2004 Dec;25(6):1875-80. | ||||||||||
| Title: | KIF27 is one of orthologs for Drosophila Costal-2. | ||||||||||
| Author: | Katoh, Yuriko|Katoh, Masaru | ||||||||||
| PMID: | 15547729 | ||||||||||
| 2. | |||||||||||
| Journal: | Int J Oncol. 2004 Dec;25(6):1881-6. | ||||||||||
| Title: | Characterization of KIF7 gene in silico. | ||||||||||
| Author: | Katoh, Yuriko|Katoh, Masaru | ||||||||||
| PMID: | 15547730 | ||||||||||
| 3. | |||||||||||
| Journal: | Int J Cancer. 2004 Jul 10;110(5):668-76. | ||||||||||
| Title: | Indian hedgehog signaling pathway: expression and regulation in pancreatic cancer. | ||||||||||
| Author: | Kayed, Hany|Kleeff, Jorg|Keleg, Shereen|Guo, Junchau|Ketterer, Knut|Berberat, Pascal O|Giese, Nathalia|Esposito, Irene|Giese, Thomas|Buchler, Markus W|Friess, Helmut | ||||||||||
| PMID: | 15146555 | ||||||||||
| 4. | |||||||||||
| Journal: | Mol Carcinog. 2005 Apr;42(4):183-92. | ||||||||||
| Title: | Localization of the human hedgehog-interacting protein (Hip) in the normal and diseased pancreas. | ||||||||||
| Author: | Kayed, Hany|Kleeff, Jorg|Esposito, Irene|Giese, Thomas|Keleg, Shereen|Giese, Nathalia|Buchler, Markus W|Friess, Helmut | ||||||||||
| PMID: | 15754313 | ||||||||||
| 5. | |||||||||||
| Journal: | Cancer Biol Ther. 2005 Oct;4(10):1050-4. Epub 2005 Oct 18. | ||||||||||
| Title: | Hedgehog signaling pathway and gastric cancer. | ||||||||||
| Author: | Katoh, Yuriko|Katoh, Masaru | ||||||||||
| PMID: | 16258256 | ||||||||||
| 6. | |||||||||||
| Journal: | Pancreas. 2006 Jul;33(1):38-44. | ||||||||||
| Title: | Aberrant expression of PTCH (patched gene) and Smo (smoothened gene) in human pancreatic cancerous tissues and its association with hyperglycemia. | ||||||||||
| Author: | Shao, Jianguo|Zhang, Ling|Gao, Jun|Li, Zhaoshen|Chen, Zhirong | ||||||||||
| PMID: | 16804411 | ||||||||||
| 7. | |||||||||||
| Journal: | Gene Ther. 2006 Nov;13(22):1587-94. Epub 2006 Jul 6. | ||||||||||
| Title: | Antisense Smo under the control of the PTCH1 promoter delivered by an adenoviral vector inhibits the growth of human pancreatic cancer. | ||||||||||
| Author: | Gao, J|Li, Z|Chen, Z|Shao, J|Zhang, L|Xu, G|Tu, Z|Gong, Y | ||||||||||
| PMID: | 16826192 | ||||||||||
| 8. | |||||||||||
| Journal: | Int J Mol Med. 2006 Dec;18(6):1019-23. | ||||||||||
| Title: | Hedgehog signaling pathway and gastrointestinal stem cell signaling network (review). | ||||||||||
| Author: | Katoh, Yuriko|Katoh, Masaru | ||||||||||
| PMID: | 17089004 | ||||||||||
| 9. | |||||||||||
| Journal: | Pancreas. 2007 Apr;34(3):340-6. | ||||||||||
| Title: | Sonic hedgehog signaling pathway in pancreatic cystic neoplasms and ductal adenocarcinoma. | ||||||||||
| Author: | Liu, Maw-Sen|Yang, Po-Yi|Yeh, Ta-Sen | ||||||||||
| PMID: | 17414057 | ||||||||||
| 10. | |||||||||||
| Journal: | Acta Pharmacol Sin. 2007 Aug;28(8):1224-30. | ||||||||||
| Title: | Blockade of sonic hedgehog signal pathway enhances antiproliferative effect of EGFR inhibitor in pancreatic cancer cells. | ||||||||||
| Author: | Hu, Wei-guo|Liu, Tao|Xiong, Jiong-xin|Wang, Chun-you | ||||||||||
| PMID: | 17640486 | ||||||||||
| 11. | |||||||||||
| Journal: | Genes Dev. 2009 Jan 1;23(1):24-36. | ||||||||||
| Title: | GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation. | ||||||||||
| Author: | Nolan-Stevaux, Olivier|Lau, Janet|Truitt, Morgan L|Chu, Gerald C|Hebrok, Matthias|Fernandez-Zapico, Martin E|Hanahan, Douglas | ||||||||||
| PMID: | 19136624 | ||||||||||
| 12. | |||||||||||
| Journal: | Cancer Lett. 2009 Oct 8;283(2):119-24. | ||||||||||
| Title: | Blockade of hedgehog signaling pathway as a therapeutic strategy for pancreatic cancer. | ||||||||||
| Author: | Xu, Fu-Guo|Ma, Qing-Yong|Wang, Zheng | ||||||||||
| PMID: | 19232458 | ||||||||||
| 13. | |||||||||||
| Journal: | Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4254-9. | ||||||||||
| Title: | Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis. | ||||||||||
| Author: | Tian, Hua|Callahan, Christopher A|DuPree, Kelly J|Darbonne, Walter C|Ahn, Christina P|Scales, Suzie J|de Sauvage, Frederic J | ||||||||||
| PMID: | 19246386 | ||||||||||
| 14. | |||||||||||
| Journal: | J Carcinog. 2009;8:13. | ||||||||||
| Title: | Gli1 maintains cell survival by up-regulating IGFBP6 and Bcl-2 through promoter regions in parallel manner in pancreatic cancer cells. | ||||||||||
| Author: | Xu, Xuan-Fu|Guo, Chuan-Yong|Liu, Jun|Yang, Wen-Juan|Xia, Yu-Jing|Xu, Ling|Yu, Yong-Chun|Wang, Xing-Peng | ||||||||||
| PMID: | 19736394 | ||||||||||
| 15. | |||||||||||
| Journal: | Langenbecks Arch Surg. 2010 Jun;395(5):515-25. | ||||||||||
| Title: | Expression and regulation of hedgehog signaling pathway in pancreatic cancer. | ||||||||||
| Author: | Yang, Yinmo|Tian, Xiaodong|Xie, Xuehai|Zhuang, Yan|Wu, Wenhan|Wang, Weimin | ||||||||||
| PMID: | 19396459 | ||||||||||
| 16. | |||||||||||
| Journal: | Curr Opin Investig Drugs. 2010 Dec;11(12):1387-98. | ||||||||||
| Title: | Agents targeting the Hedgehog pathway for pancreatic cancer treatment. | ||||||||||
| Author: | Bisht, Savita|Brossart, Peter|Maitra, Anirban|Feldmann, Georg | ||||||||||
| PMID: | 21154121 | ||||||||||
| 17. | |||||||||||
| Journal: | Cancer Biol Ther. 2010 Jul 1;10(1):79-88. Epub 2010 Jul 26. | ||||||||||
| Title: | Assessing the efficacy of the hedgehog pathway inhibitor vitamin D3 in a murine xenograft model for pancreatic cancer. | ||||||||||
| Author: | Bruggemann, Lois W|Queiroz, Karla C S|Zamani, Khatera|van Straaten, Amber|Spek, C Arnold|Bijlsma, Maarten F | ||||||||||
| PMID: | 20495364 | ||||||||||
| 18. | |||||||||||
| Journal: | Clin Cancer Res. 2010 Mar 15;16(6):1781-9. | ||||||||||
| Title: | Overexpression of smoothened activates the sonic hedgehog signaling pathway in pancreatic cancer-associated fibroblasts. | ||||||||||
| Author: | Walter, Kimberly|Omura, Noriyuki|Hong, Seung-Mo|Griffith, Margaret|Vincent, Audrey|Borges, Michael|Goggins, Michael | ||||||||||
| PMID: | 20215540 | ||||||||||
| 19. | |||||||||||
| Journal: | Mol Biosyst. 2010 Jan;6(1):44-54. | ||||||||||
| Title: | Small-molecule modulators of the Sonic Hedgehog signaling pathway. | ||||||||||
| Author: | Stanton, Benjamin Z|Peng, Lee F | ||||||||||
| PMID: | 20024066 | ||||||||||
| 20. | |||||||||||
| Journal: | Mol Biosyst. 2010 Jan;6(1):44-54. | ||||||||||
| Title: | Small-molecule modulators of the Sonic Hedgehog signaling pathway. | ||||||||||
| Author: | Stanton, Benjamin Z|Peng, Lee F | ||||||||||
| PMID: | 17430192 | ||||||||||
| 21. | |||||||||||
| Journal: | Cancer Sci. 2011 Jun;102(6):1144-50. | ||||||||||
| Title: | Hypoxia activates the hedgehog signaling pathway in a ligand-independent manner by upregulation of Smo transcription in pancreatic cancer. | ||||||||||
| Author: | Onishi, Hideya|Kai, Masaya|Odate, Seiichi|Iwasaki, Hironori|Morifuji, Yoshihiro|Ogino, Toshitatsu|Morisaki, Takafumi|Nakashima, Yutaka|Katano, Mitsuo | ||||||||||
| PMID: | 21338440 | ||||||||||
| 22. | |||||||||||
| Journal: | Swiss Med Wkly. 2011 May 31;141:w13208. | ||||||||||
| Title: | Cyclopamine reverts acquired chemoresistance and down-regulates cancer stem cell markers in pancreatic cancer cell lines. | ||||||||||
| Author: | Yao, Jie|An, Yong|Wie, Ji-shu|Ji, Zhen-ling|Lu, Zi-peng|Wu, Jun-li|Jiang, Kui-rong|Chen, Ping|Xu, Ze-kuan|Miao, Yi | ||||||||||
| PMID: | 21630164 | ||||||||||
| 23. | |||||||||||
| Journal: | J Biol Chem. 2011 Sep 2;286(35):30714-22. | ||||||||||
| Title: | The alpha subunit of the G protein G13 regulates activity of one or more Gli transcription factors independently of smoothened. | ||||||||||
| Author: | Douglas, Andrew E|Heim, Jennifer A|Shen, Feng|Almada, Luciana L|Riobo, Natalia A|Fernandez-Zapico, Martin E|Manning, David R | ||||||||||
| PMID: | 21757753 | ||||||||||
| 24. | |||||||||||
| Journal: | PLoS One. 2011;6(12):e27941. | ||||||||||
| Title: | Aberrant Hedgehog ligands induce progressive pancreatic fibrosis by paracrine activation of myofibroblasts and ductular cells in transgenic zebrafish. | ||||||||||
| Author: | Jung, In Hye|Jung, Dawoon E|Park, Young Nyun|Song, Si Young|Park, Seung Woo | ||||||||||
| PMID: | 22164219 | ||||||||||
| 25. | |||||||||||
| Journal: | Pancreatology. 2011;11(6):601-9. | ||||||||||
| Title: | Resveratrol inhibits proliferation and induces apoptosis through the hedgehog signaling pathway in pancreatic cancer cell. | ||||||||||
| Author: | Mo, Wenhui|Xu, Xuanfu|Xu, Ling|Wang, Feng|Ke, Aiwu|Wang, Xingpeng|Guo, Chuanyong | ||||||||||
| PMID: | 22301921 | ||||||||||
| 26. | |||||||||||
| Journal: | Zhonghua Yi Xue Za Zhi. 2011 Nov 29;91(44):3103-6. | ||||||||||
| Title: | [Regulatory mechanisms of Hedgehog signaling pathway for epithelial-mesenchymal transition in pancreatic cancer cells]. | ||||||||||
| Author: | Xie, Kun|Hao, Kun|Tian, Xiao-dong|Chang, Zhi-gang|Qin, Chang-fu|Yang, Yin-mo | ||||||||||
| PMID: | 22340649 | ||||||||||
| 27. | |||||||||||
| Journal: | J Gastrointest Oncol. 2011 Jun;2(2):93-103. | ||||||||||
| Title: | Emerging therapies in pancreas cancer. | ||||||||||
| Author: | Kotowski, Adam|Ma, Wen W | ||||||||||
| PMID: | 22811835 | ||||||||||
| 28. | |||||||||||
| Journal: | Int J Oncol. 2012 Nov;41(5):1707-14. | ||||||||||
| Title: | Inhibition of hedgehog signaling depresses self-renewal of pancreatic cancer stem cells and reverses chemoresistance. | ||||||||||
| Author: | Huang, Feng-Ting|Zhuan-Sun, Yong-Xun|Zhuang, Yan-Yan|Wei, Shu-Li|Tang, Jian|Chen, Wen-Bo|Zhang, Shi-Neng | ||||||||||
| PMID: | 22923052 | ||||||||||
| 29. | |||||||||||
| Journal: | Mol Cancer Res. 2012 Sep;10(9):1147-57. Epub 2012 Aug 2. | ||||||||||
| Title: | Inhibition of the hedgehog pathway targets the tumor-associated stroma in pancreatic cancer. | ||||||||||
| Author: | Hwang, Rosa F|Moore, Todd T|Hattersley, Maureen Mertens|Scarpitti, Meghan|Yang, Bin|Devereaux, Erik|Ramachandran, Vijaya|Arumugam, Thiruvengadam|Ji, Baoan|Logsdon, Craig D|Brown, Jeffrey L|Godin, Robert | ||||||||||
| PMID: | 22859707 | ||||||||||
| 30. | |||||||||||
| Journal: | Cancer Sci. 2012 Jul;103(7):1272-9. | ||||||||||
| Title: | Hedgehog inhibitor decreases chemosensitivity to 5-fluorouracil and gemcitabine under hypoxic conditions in pancreatic cancer. | ||||||||||
| Author: | Onishi, Hideya|Morifuji, Yoshihiro|Kai, Masaya|Suyama, Kumi|Iwasaki, Hironori|Katano, Mitsuo | ||||||||||
| PMID: | 22486854 | ||||||||||
| 31. | |||||||||||
| Journal: | Zhong Xi Yi Jie He Xue Bao. 2012 Mar;10(3):256-63. | ||||||||||
| Title: | Advances in Smoothened-targeting therapies for pancreatic cancer: implication for drug discovery from herbal medicines. | ||||||||||
| Author: | Han, Jin-bin|Hua, Yong-qiang|Chen, Lian-yu|Liu, Lu-ming | ||||||||||
| PMID: | 22409914 | ||||||||||
| 32. | |||||||||||
| Journal: | Mol Cancer Ther. 2012 Jan;11(1):165-73. | ||||||||||
| Title: | A polymeric nanoparticle encapsulated small-molecule inhibitor of Hedgehog signaling (NanoHHI) bypasses secondary mutational resistance to Smoothened antagonists. | ||||||||||
| Author: | Chenna, Venugopal|Hu, Chaoxin|Pramanik, Dipankar|Aftab, Blake T|Karikari, Collins|Campbell, Nathaniel R|Hong, Seung-Mo|Zhao, Ming|Rudek, Michelle A|Khan, Saeed R|Rudin, Charles M|Maitra, Anirban | ||||||||||
| PMID: | 22027695 | ||||||||||
| 33. | |||||||||||
| Journal: | Cancer Lett. 2012 Sep 28;322(2):169-76. | ||||||||||
| Title: | SDF-1/CXCR4 signaling induces pancreatic cancer cell invasion and epithelial-mesenchymal transition in vitro through non-canonical activation of Hedgehog pathway. | ||||||||||
| Author: | Li, Xuqi|Ma, Qingyong|Xu, Qinhong|Liu, Han|Lei, Jianjun|Duan, Wanxing|Bhat, Kruttika|Wang, Fengfei|Wu, Erxi|Wang, Zheng | ||||||||||
| PMID: | 22450749 | ||||||||||
| 34. | |||||||||||
| Journal: | Mol Cell Biochem. 2013 Jan;373(1-2):217-27. | ||||||||||
| Title: | Sulforaphane regulates self-renewal of pancreatic cancer stem cells through the modulation of Sonic hedgehog-GLI pathway. | ||||||||||
| Author: | Li, Shih-Hui|Fu, Junsheng|Watkins, Dara Nall|Srivastava, Rakesh K|Shankar, Sharmila | ||||||||||
| PMID: | 23129257 | ||||||||||
| 35. | |||||||||||
| Journal: | Drug Metab Dispos. 2013 Apr;41(4):727-34. | ||||||||||
| Title: | Pharmacokinetic and pharmacodynamic modeling of hedgehog inhibitor TAK-441 for the inhibition of Gli1 messenger RNA expression and antitumor efficacy in xenografted tumor model mice. | ||||||||||
| Author: | Kogame, Akifumi|Tagawa, Yoshihiko|Shibata, Sachio|Tojo, Hideaki|Miyamoto, Maki|Tohyama, Kimio|Kondo, Takahiro|Prakash, Shimoga|Shyu, Wen Chyi|Asahi, Satoru | ||||||||||
| PMID: | 23298863 | ||||||||||
| 36. | |||||||||||
| Journal: | Hered Cancer Clin Pract. 2013 Apr 1;11(1):2. | ||||||||||
| Title: | Systemic treatment for hereditary cancers: a 2012 update. | ||||||||||
| Author: | Imyanitov, Evgeny N|Byrski, Tomasz | ||||||||||
| PMID: | 23548133 | ||||||||||
| 37. | |||||||||||
| Journal: | J Pharmacol Pharmacother. 2013 Jan;4(1):4-7. | ||||||||||
| Title: | The dawn of hedgehog inhibitors: Vismodegib. | ||||||||||
| Author: | Sandhiya, Selvarajan|Melvin, George|Kumar, Srinivasamurthy Suresh|Dkhar, Steven Aibor | ||||||||||
| PMID: | 23662017 | ||||||||||
| 38. | |||||||||||
| Journal: | Mol Cancer. 2013 Jun 20;12:66. | ||||||||||
| Title: | Hedgehog signaling regulates hypoxia induced epithelial to mesenchymal transition and invasion in pancreatic cancer cells via a ligand-independent manner. | ||||||||||
| Author: | Lei, Jianjun|Ma, Jiguang|Ma, Qingyong|Li, Xuqi|Liu, Han|Xu, Qinhong|Duan, Wanxing|Sun, Qing|Xu, Jun|Wu, Zheng|Wu, Erxi | ||||||||||
| PMID: | 23786654 | ||||||||||
| 39. | |||||||||||
| Journal: | Cancer Lett. 2013 Oct 10;339(2):185-94. | ||||||||||
| Title: | Adenovirus vector-mediated Gli1 siRNA induces growth inhibition and apoptosis in human pancreatic cancer with Smo-dependent or Smo-independent Hh pathway activation in vitro and in vivo. | ||||||||||
| Author: | Guo, Jiefang|Gao, Jun|Li, Zhaoshen|Gong, Yanfang|Man, Xiaohua|Jin, Jing|Wu, Hongyu | ||||||||||
| PMID: | 23791879 | ||||||||||
| 40. | |||||||||||
| Journal: | PLoS One. 2013 Jul 23;8(7):e69132. | ||||||||||
| Title: | Structural and logical analysis of a comprehensive hedgehog signaling pathway to identify alternative drug targets for glioma, colon and pancreatic cancer. | ||||||||||
| Author: | Chowdhury, Saikat|Pradhan, Rachana N|Sarkar, Ram Rup | ||||||||||
| PMID: | 23935937 | ||||||||||
| 41. | |||||||||||
| Journal: | World J Gastroenterol. 2014 Apr 28;20(16):4712-7. | ||||||||||
| Title: | Sonic hedgehog expression in a rat model of chronic pancreatitis. | ||||||||||
| Author: | Wang, Luo-Wei|Lin, Han|Lu, Yi|Xia, Wei|Gao, Jun|Li, Zhao-Shen | ||||||||||
| PMID: | 24782623 | ||||||||||
| 42. | |||||||||||
| Journal: | Mol Med Rep. 2014 Nov;10(5):2563-7. | ||||||||||
| Title: | Effect of resveratrol on proliferation and apoptosis of human pancreatic cancer MIA PaCa-2 cells may involve inhibition of the Hedgehog signaling pathway. | ||||||||||
| Author: | Qin, Yong|Ma, Zhenhua|Dang, Xiaoyan|Li, Wei|Ma, Qingyong | ||||||||||
| PMID: | 25190613 | ||||||||||
| 43. | |||||||||||
| Journal: | Biochem Biophys Res Commun. 2014 Apr 11;446(3):669-74. | ||||||||||
| Title: | Metabolites in vertebrate Hedgehog signaling. | ||||||||||
| Author: | Roberg-Larsen, Hanne|Strand, Martin Frank|Krauss, Stefan|Wilson, Steven Ray | ||||||||||
| PMID: | 24486313 | ||||||||||
| 44. | |||||||||||
| Journal: | Cancer Biol Ther. 2015;16(2):219-24. | ||||||||||
| Title: | PTCH 1 staining of pancreatic neuroendocrine tumor (PNET) samples from patients with and without multiple endocrine neoplasia (MEN-1) syndrome reveals a potential therapeutic target. | ||||||||||
| Author: | Gurung, Buddha|Hua, Xianxin|Runske, Melissa|Bennett, Bonita|LiVolsi, Virginia|Roses, Robert|Fraker, Douglas A|Metz, David C | ||||||||||
| PMID: | 25482929 | ||||||||||
| 45. | |||||||||||
| Journal: | Cancer Res. 2015 Jun 1;75(11):2292-304. | ||||||||||
| Title: | Ormeloxifene suppresses desmoplasia and enhances sensitivity of gemcitabine in pancreatic cancer. | ||||||||||
| Author: | Khan, Sheema|Ebeling, Mara C|Chauhan, Neeraj|Thompson, Paul A|Gara, Rishi K|Ganju, Aditya|Yallapu, Murali M|Behrman, Stephen W|Zhao, Haotian|Zafar, Nadeem|Singh, Man Mohan|Jaggi, Meena|Chauhan, Subhash C | ||||||||||
| PMID: | 25840985 | ||||||||||
| 46. | |||||||||||
| Journal: | Drugs. 2015 Sep;75(13):1559-66. | ||||||||||
| Title: | Sonidegib: First Global Approval. | ||||||||||
| Author: | Burness, Celeste B | ||||||||||
| PMID: | 26323341 | ||||||||||
| 47. | |||||||||||
| Journal: | J Clin Oncol. 2015 Dec 20;33(36):4284-92. | ||||||||||
| Title: | Randomized Phase Ib/II Study of Gemcitabine Plus Placebo or Vismodegib, a Hedgehog Pathway Inhibitor, in Patients With Metastatic Pancreatic Cancer. | ||||||||||
| Author: | Catenacci, Daniel V T|Junttila, Melissa R|Karrison, Theodore|Bahary, Nathan|Horiba, Margit N|Nattam, Sreenivasa R|Marsh, Robert|Wallace, James|Kozloff, Mark|Rajdev, Lakshmi|Cohen, Deirdre|Wade, James|Sleckman, Bethany|Lenz, Heinz-Josef|Stiff, Patrick|Kuma | ||||||||||
| PMID: | 26527777 | ||||||||||
| 48. | |||||||||||
| Journal: | Cancer Lett. 2016 Feb 28;371(2):143-50. | ||||||||||
| Title: | Hypoxia but not normoxia promotes Smoothened transcription through upregulation of RBPJ and Mastermind-like 3 in pancreatic cancer. | ||||||||||
| Author: | Onishi, Hideya|Yamasaki, Akio|Kawamoto, Makoto|Imaizumi, Akira|Katano, Mitsuo | ||||||||||
| PMID: | 26655998 | ||||||||||
| 49. | |||||||||||
| Journal: | PLoS One. 2016 Oct 26;11(10):e0164231. | ||||||||||
| Title: | Epithelial to Stromal Re-Distribution of Primary Cilia during Pancreatic Carcinogenesis. | ||||||||||
| Author: | Schimmack, Simon|Kneller, Sarah|Dadabaeva, Nigora|Bergmann, Frank|Taylor, Andrew|Hackert, Thilo|Werner, Jens|Strobel, Oliver | ||||||||||
| PMID: | 27783689 | ||||||||||
| 50. | |||||||||||
| Journal: | Tumour Biol. 2016 Oct 12. pii: 10.1007/s13277-016-5461-8. | ||||||||||
| Title: | Ski modulate the characteristics of pancreatic cancer stem cells via regulating sonic hedgehog signaling pathway. | ||||||||||
| Author: | Song, Libin|Chen, Xiangyuan|Gao, Song|Zhang, Chenyue|Qu, Chao|Wang, Peng|Liu, Luming | ||||||||||
| PMID: | 27734340 | ||||||||||
| 51. | |||||||||||
| Journal: | Genes Dev. 2016 Sep 1;30(17):1911-2. | ||||||||||
| Title: | Pancreatic fibroblasts smoothen their activities via AKT-GLI2-TGFalpha. | ||||||||||
| Author: | Rustgi, Anil K | ||||||||||
| PMID: | 27664234 | ||||||||||
| 52. | |||||||||||
| Journal: | Genes Dev. 2016 Sep 1;30(17):1943-55. | ||||||||||
| Title: | Genetic ablation of Smoothened in pancreatic fibroblasts increases acinar-ductal metaplasia. | ||||||||||
| Author: | Liu, Xin|Pitarresi, Jason R|Cuitino, Maria C|Kladney, Raleigh D|Woelke, Sarah A|Sizemore, Gina M|Nayak, Sunayana G|Egriboz, Onur|Schweickert, Patrick G|Yu, Lianbo|Trela, Stefan|Schilling, Daniel J|Halloran, Shannon K|Li, Maokun|Dutta, Shourik|Fernandez, S | ||||||||||
| PMID: | 27633013 | ||||||||||
| 53. | |||||||||||
| Journal: | Anticancer Res. 2016 Aug;36(8):3945-52. | ||||||||||
| Title: | Protein-bound Polysaccharide-K Inhibits Hedgehog Signaling Through Down-regulation of MAML3 and RBPJ Transcription Under Hypoxia, Suppressing the Malignant Phenotype in Pancreatic Cancer. | ||||||||||
| Author: | Yamasaki, Akio|Onishi, Hideya|Imaizumi, Akira|Kawamoto, Makoto|Fujimura, Akiko|Oyama, Yasuhiro|Katano, Mitsuo | ||||||||||
| PMID: | 27466498 | ||||||||||
| 54. | |||||||||||
| Journal: | Mol Cancer. 2016 Jun 27;15(1):49. | ||||||||||
| Title: | Efficient elimination of pancreatic cancer stem cells by hedgehog/GLI inhibitor GANT61 in combination with mTOR inhibition. | ||||||||||
| Author: | Miyazaki, Yumi|Matsubara, Shyuichirou|Ding, Qiang|Tsukasa, Koichiro|Yoshimitsu, Makoto|Kosai, Ken-Ichiro|Takao, Sonshin | ||||||||||
| PMID: | 27349387 | ||||||||||
| 55. | |||||||||||
| Journal: | Oncol Rep. 2016 Jun;35(6):3728-34. | ||||||||||
| Title: | Curcumin inhibits hypoxia-induced epithelialmesenchymal transition in pancreatic cancer cells via suppression of the hedgehog signaling pathway. | ||||||||||
| Author: | Cao, Lei|Xiao, Xue|Lei, Jianjun|Duan, Wanxing|Ma, Qingyong|Li, Wei | ||||||||||
| PMID: | 27035865 | ||||||||||
| 56. | |||||||||||
| Journal: | J Cancer. 2016 Jan 20;7(4):408-17. | ||||||||||
| Title: | Hedgehog Signaling Regulates Epithelial-Mesenchymal Transition in Pancreatic Cancer Stem-Like Cells. | ||||||||||
| Author: | Wang, Feng|Ma, Ling|Zhang, Zhengkui|Liu, Xiaoran|Gao, Hongqiao|Zhuang, Yan|Yang, Pei|Kornmann, Marko|Tian, Xiaodong|Yang, Yinmo | ||||||||||
| PMID: | 26918054 | ||||||||||
| 57. | |||||||||||
| Journal: | Mol Med Rep. 2016 Feb;13(2):1434-40. | ||||||||||
| Title: | Reduced proliferation and increased apoptosis of the SGC7901 gastric cancer cell line on exposure to GDC0449. | ||||||||||
| Author: | Wu, Chuanqing|Cheng, Ji|Hu, Shaobo|Deng, Rui|Muangu, Yamba Willy|Shi, Liang|Wu, Ke|Zhang, Peng|Chang, Weilong|Wang, Guobin|Tao, Kaixiong | ||||||||||
| PMID: | 26676867 | ||||||||||
| 58. | |||||||||||
| Journal: | J Cell Biochem. 2017 Mar;118(3):499-509. | ||||||||||
| Title: | Inhibition of Pancreatic Cancer Cell-Induced Paracrine Hedgehog Signaling by Liver X Receptor Agonists and Oxy16, a Naturally Occurring Oxysterol. | ||||||||||
| Author: | Wang, Feng|Stappenbeck, Frank|Matsui, William|Parhami, Farhad | ||||||||||
| PMID: | 27490478 | ||||||||||
| 59. | |||||||||||
| Journal: | Sci Rep. 2017 May 10;7(1):1665. | ||||||||||
| Title: | Design, Synthesis and Biological Evaluation of novel Hedgehog Inhibitors for treating Pancreatic Cancer. | ||||||||||
| Author: | Kumar, Vinod|Chaudhary, Amit Kumar|Dong, Yuxiang|Zhong, Haizhen A|Mondal, Goutam|Lin, Feng|Kumar, Virender|Mahato, Ram I | ||||||||||
| PMID: | 28490735 | ||||||||||
| 60. | |||||||||||
| Journal: | Exp Ther Med. 2017 May;13(5):2529-2536. | ||||||||||
| Title: | Smoothened antagonist GDC-0449 (Vismodegib) inhibits proliferation and triggers apoptosis in colon cancer cell lines. | ||||||||||
| Author: | Wu, Chuanqing|Hu, Shaobo|Cheng, Ji|Wang, Guobin|Tao, Kaixiong | ||||||||||
| PMID: | 28565875 | ||||||||||
| 61. | |||||||||||
| Journal: | Sci Rep. 2017 Oct 17;7(1):13379. | ||||||||||
| Title: | GDC-0449 improves the antitumor activity of nano-doxorubicin in pancreatic cancer in a fibroblast-enriched microenvironment. | ||||||||||
| Author: | Zhou, Quan|Zhou, Yongcun|Liu, Xiangrui|Shen, Youqing | ||||||||||
| PMID: | 29042665 | ||||||||||
| 62. | |||||||||||
| Journal: | Acta Biochim Biophys Sin (Shanghai). 2018 Jun 1;50(6):586-596. | ||||||||||
| Title: | Effects of baicalein on pancreatic cancer stem cells via modulation of sonic Hedgehog pathway. | ||||||||||
| Author: | Song, Libin|Chen, Xiangyuan|Wang, Peng|Gao, Song|Qu, Chao|Liu, Luming | ||||||||||
| PMID: | 29697746 | ||||||||||
| 63. | |||||||||||
| Journal: | J Pharmacol Sci. 2018 Jul;137(3):256-264. | ||||||||||
| Title: | Discovery of a potent hedgehog pathway inhibitor capable of activating caspase8-dependent apoptosis. | ||||||||||
| Author: | Chen, Qin|Zhang, Haoran|Wu, Meng|Wang, Qin|Luo, Lusong|Ma, Haikuo|Zhang, Xiaohu|He, Sudan | ||||||||||
| PMID: | 30064819 | ||||||||||
| 64. | |||||||||||
| Journal: | Oncol Lett. 2018 Oct;16(4):4855-4862. | ||||||||||
| Title: | Expression of Smo in pancreatic cancer CD44(+)CD24(+)cells and construction of a lentiviral expression vector to silence Smo. | ||||||||||
| Author: | Cong, Peng|Yi, Chao|Wang, Xi-Yan | ||||||||||
| PMID: | 30250551 | ||||||||||
| 65. | |||||||||||
| Journal: | Oncogene. 2018 Oct 31. pii: 10.1038/s41388-018-0553-0. | ||||||||||
| Title: | The role of GLI-SOX2 signaling axis for gemcitabine resistance in pancreatic cancer. | ||||||||||
| Author: | Jia, Yanfei|Gu, Dongsheng|Wan, Jun|Yu, Beiqin|Zhang, Xiaoli|Chiorean, E Gabriela|Wang, Yunshan|Xie, Jingwu | ||||||||||
| PMID: | 30382189 | ||||||||||