Primary Site >> Pancreatic Cancer
Gene >> SMO
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Ref: Indian hedgehog signaling pathway: expression and regulation in pancreatic cancer. PMID: 15146555 Ref: KIF27 is one of orthologs for Drosophila Costal-2. PMID: 15547729 Ref: Characterization of KIF7 gene in silico. PMID: 15547730 |
Ref: Localization of the human hedgehog-interacting protein (Hip) in the normal and diseased pancreas. PMID: 15754313 Ref: Hedgehog signaling pathway and gastric cancer. PMID: 16258256 |
Ref: Aberrant expression of PTCH (patched gene) and Smo (smoothened gene) in human pancreatic cancerous tissues and its association with hyperglycemia. PMID: 16804411 Ref: Antisense Smo under the control of the PTCH1 promoter delivered by an adenoviral vector inhibits the growth of human pancreatic cancer. PMID: 16826192 Ref: Hedgehog signaling pathway and gastrointestinal stem cell signaling network (review). PMID: 17089004 |
Ref: Sonic hedgehog signaling pathway in pancreatic cystic neoplasms and ductal adenocarcinoma. PMID: 17414057 Ref: Blockade of sonic hedgehog signal pathway enhances antiproliferative effect of EGFR inhibitor in pancreatic cancer cells. PMID: 17640486 |
Ref: GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation. PMID: 19136624 Ref: Blockade of hedgehog signaling pathway as a therapeutic strategy for pancreatic cancer. PMID: 19232458 Ref: Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis. PMID: 19246386 Ref: Gli1 maintains cell survival by up-regulating IGFBP6 and Bcl-2 through promoter regions in parallel manner in pancreatic cancer cells. PMID: 19736394 |
Ref: Small-molecule modulators of the Sonic Hedgehog signaling pathway. PMID: 17430192 Ref: Expression and regulation of hedgehog signaling pathway in pancreatic cancer. PMID: 19396459 Ref: Small-molecule modulators of the Sonic Hedgehog signaling pathway. PMID: 20024066 Ref: Overexpression of smoothened activates the sonic hedgehog signaling pathway in pancreatic cancer-associated fibroblasts. PMID: 20215540 Ref: Assessing the efficacy of the hedgehog pathway inhibitor vitamin D3 in a murine xenograft model for pancreatic cancer. PMID: 20495364 Ref: Agents targeting the Hedgehog pathway for pancreatic cancer treatment. PMID: 21154121 |
Ref: Hypoxia activates the hedgehog signaling pathway in a ligand-independent manner by upregulation of Smo transcription in pancreatic cancer. PMID: 21338440 Ref: Cyclopamine reverts acquired chemoresistance and down-regulates cancer stem cell markers in pancreatic cancer cell lines. PMID: 21630164 Ref: The alpha subunit of the G protein G13 regulates activity of one or more Gli transcription factors independently of smoothened. PMID: 21757753 Ref: Aberrant Hedgehog ligands induce progressive pancreatic fibrosis by paracrine activation of myofibroblasts and ductular cells in transgenic zebrafish. PMID: 22164219 Ref: Resveratrol inhibits proliferation and induces apoptosis through the hedgehog signaling pathway in pancreatic cancer cell. PMID: 22301921 Ref: [Regulatory mechanisms of Hedgehog signaling pathway for epithelial-mesenchymal transition in pancreatic cancer cells]. PMID: 22340649 Ref: Emerging therapies in pancreas cancer. PMID: 22811835 |
Ref: A polymeric nanoparticle encapsulated small-molecule inhibitor of Hedgehog signaling (NanoHHI) bypasses secondary mutational resistance to Smoothened antagonists. PMID: 22027695 Ref: Advances in Smoothened-targeting therapies for pancreatic cancer: implication for drug discovery from herbal medicines. PMID: 22409914 Ref: SDF-1/CXCR4 signaling induces pancreatic cancer cell invasion and epithelial-mesenchymal transition in vitro through non-canonical activation of Hedgehog pathway. PMID: 22450749 Ref: Hedgehog inhibitor decreases chemosensitivity to 5-fluorouracil and gemcitabine under hypoxic conditions in pancreatic cancer. PMID: 22486854 Ref: Inhibition of the hedgehog pathway targets the tumor-associated stroma in pancreatic cancer. PMID: 22859707 Ref: Inhibition of hedgehog signaling depresses self-renewal of pancreatic cancer stem cells and reverses chemoresistance. PMID: 22923052 |
Ref: Sulforaphane regulates self-renewal of pancreatic cancer stem cells through the modulation of Sonic hedgehog-GLI pathway. PMID: 23129257 Ref: Pharmacokinetic and pharmacodynamic modeling of hedgehog inhibitor TAK-441 for the inhibition of Gli1 messenger RNA expression and antitumor efficacy in xenografted tumor model mice. PMID: 23298863 Ref: Systemic treatment for hereditary cancers: a 2012 update. PMID: 23548133 Ref: The dawn of hedgehog inhibitors: Vismodegib. PMID: 23662017 Ref: Hedgehog signaling regulates hypoxia induced epithelial to mesenchymal transition and invasion in pancreatic cancer cells via a ligand-independent manner. PMID: 23786654 Ref: Adenovirus vector-mediated Gli1 siRNA induces growth inhibition and apoptosis in human pancreatic cancer with Smo-dependent or Smo-independent Hh pathway activation in vitro and in vivo. PMID: 23791879 Ref: Structural and logical analysis of a comprehensive hedgehog signaling pathway to identify alternative drug targets for glioma, colon and pancreatic cancer. PMID: 23935937 |
Ref: Metabolites in vertebrate Hedgehog signaling. PMID: 24486313 Ref: Sonic hedgehog expression in a rat model of chronic pancreatitis. PMID: 24782623 Ref: Effect of resveratrol on proliferation and apoptosis of human pancreatic cancer MIA PaCa-2 cells may involve inhibition of the Hedgehog signaling pathway. PMID: 25190613 |
Ref: PTCH 1 staining of pancreatic neuroendocrine tumor (PNET) samples from patients with and without multiple endocrine neoplasia (MEN-1) syndrome reveals a potential therapeutic target. PMID: 25482929 Ref: Ormeloxifene suppresses desmoplasia and enhances sensitivity of gemcitabine in pancreatic cancer. PMID: 25840985 Ref: Sonidegib: First Global Approval. PMID: 26323341 Ref: Randomized Phase Ib/II Study of Gemcitabine Plus Placebo or Vismodegib, a Hedgehog Pathway Inhibitor, in Patients With Metastatic Pancreatic Cancer. PMID: 26527777 |
Ref: Hypoxia but not normoxia promotes Smoothened transcription through upregulation of RBPJ and Mastermind-like 3 in pancreatic cancer. PMID: 26655998 Ref: Reduced proliferation and increased apoptosis of the SGC7901 gastric cancer cell line on exposure to GDC0449. PMID: 26676867 Ref: Hedgehog Signaling Regulates Epithelial-Mesenchymal Transition in Pancreatic Cancer Stem-Like Cells. PMID: 26918054 Ref: Curcumin inhibits hypoxia-induced epithelialmesenchymal transition in pancreatic cancer cells via suppression of the hedgehog signaling pathway. PMID: 27035865 Ref: Efficient elimination of pancreatic cancer stem cells by hedgehog/GLI inhibitor GANT61 in combination with mTOR inhibition. PMID: 27349387 Ref: Protein-bound Polysaccharide-K Inhibits Hedgehog Signaling Through Down-regulation of MAML3 and RBPJ Transcription Under Hypoxia, Suppressing the Malignant Phenotype in Pancreatic Cancer. PMID: 27466498 Ref: Genetic ablation of Smoothened in pancreatic fibroblasts increases acinar-ductal metaplasia. PMID: 27633013 Ref: Pancreatic fibroblasts smoothen their activities via AKT-GLI2-TGFalpha. PMID: 27664234 Ref: Ski modulate the characteristics of pancreatic cancer stem cells via regulating sonic hedgehog signaling pathway. PMID: 27734340 Ref: Epithelial to Stromal Re-Distribution of Primary Cilia during Pancreatic Carcinogenesis. PMID: 27783689 |
Ref: Inhibition of Pancreatic Cancer Cell-Induced Paracrine Hedgehog Signaling by Liver X Receptor Agonists and Oxy16, a Naturally Occurring Oxysterol. PMID: 27490478 Ref: Design, Synthesis and Biological Evaluation of novel Hedgehog Inhibitors for treating Pancreatic Cancer. PMID: 28490735 Ref: Smoothened antagonist GDC-0449 (Vismodegib) inhibits proliferation and triggers apoptosis in colon cancer cell lines. PMID: 28565875 Ref: GDC-0449 improves the antitumor activity of nano-doxorubicin in pancreatic cancer in a fibroblast-enriched microenvironment. PMID: 29042665 |
Ref: Effects of baicalein on pancreatic cancer stem cells via modulation of sonic Hedgehog pathway. PMID: 29697746 Ref: Discovery of a potent hedgehog pathway inhibitor capable of activating caspase8-dependent apoptosis. PMID: 30064819 Ref: Expression of Smo in pancreatic cancer CD44(+)CD24(+)cells and construction of a lentiviral expression vector to silence Smo. PMID: 30250551 Ref: The role of GLI-SOX2 signaling axis for gemcitabine resistance in pancreatic cancer. PMID: 30382189 |