Primary Site >> Colorectal Cancer
Gene >> SMO
| 1. | |||||||||||
| Journal: | Eur J Cancer. 1999 May;35(5):711-3. | ||||||||||
| Title: | The patched/hedgehog/smoothened signalling pathway in human breast cancer: no evidence for H133Y SHH, PTCH and SMO mutations. | ||||||||||
| Author: | Vorechovsky, I|Benediktsson, K P|Toftgard, R | ||||||||||
| PMID: | 10505029 | ||||||||||
| 2. | |||||||||||
| Journal: | Cancer Lett. 2004 Apr 30;207(2):205-14. | ||||||||||
| Title: | Functional Smoothened is required for expression of GLI3 in colorectal carcinoma cells. | ||||||||||
| Author: | Zhu, Yanhua|James, Roberta M|Peter, Audrey|Lomas, Claire|Cheung, Francis|Harrison, David J|Bader, Scott A | ||||||||||
| PMID: | 15072830 | ||||||||||
| 3. | |||||||||||
| Journal: | J Pathol. 2004 Aug;203(4):909-17. | ||||||||||
| Title: | Expression of Sonic hedgehog pathway genes is altered in colonic neoplasia. | ||||||||||
| Author: | Oniscu, Anca|James, Roberta M|Morris, Robert G|Bader, Scott|Malcomson, Roger D G|Harrison, David J | ||||||||||
| PMID: | 15258993 | ||||||||||
| 4. | |||||||||||
| Journal: | Amino Acids. 2004 Jul;26(4):353-65. | ||||||||||
| Title: | Inhibitors of polyamine metabolism: review article. | ||||||||||
| Author: | Wallace, H M|Fraser, A V | ||||||||||
| PMID: | 15290341 | ||||||||||
| 5. | |||||||||||
| Journal: | Int J Mol Med. 2006 Dec;18(6):1019-23. | ||||||||||
| Title: | Hedgehog signaling pathway and gastrointestinal stem cell signaling network (review). | ||||||||||
| Author: | Katoh, Yuriko|Katoh, Masaru | ||||||||||
| PMID: | 17089004 | ||||||||||
| 6. | |||||||||||
| Journal: | Int J Cancer. 2007 Dec 15;121(12):2622-7. | ||||||||||
| Title: | Hedgehog signaling pathway is inactive in colorectal cancer cell lines. | ||||||||||
| Author: | Chatel, Guillaume|Ganeff, Corine|Boussif, Naima|Delacroix, Laurence|Briquet, Alexandra|Nolens, Gregory|Winkler, Rosita | ||||||||||
| PMID: | 17683069 | ||||||||||
| 7. | |||||||||||
| Journal: | Nan Fang Yi Ke Da Xue Xue Bao. 2007 Sep;27(9):1414-7. | ||||||||||
| Title: | [Effects of specific small interfering RNA on Smoothened expression and LoVo cell proliferation and apoptosis]. | ||||||||||
| Author: | Zhu, Da-jian|Fang, Chi-hua|Rong, Zhen-xiang|Liu, Sheng-jun | ||||||||||
| PMID: | 17884791 | ||||||||||
| 8. | |||||||||||
| Journal: | Cancer Biol Ther. 2008 Oct;7(10):1570-80. Epub 2008 Oct 7. | ||||||||||
| Title: | HDAC3 impacts multiple oncogenic pathways in colon cancer cells with effects on Wnt and vitamin D signaling. | ||||||||||
| Author: | Godman, Cassandra A|Joshi, Rashmi|Tierney, Brendan R|Greenspan, Emily|Rasmussen, Theodore P|Wang, Hsin-Wei|Shin, Dong-Guk|Rosenberg, Daniel W|Giardina, Charles | ||||||||||
| PMID: | 18769117 | ||||||||||
| 9. | |||||||||||
| Journal: | Gastroenterology. 2009 Aug;137(2):629-38. | ||||||||||
| Title: | Reduced level of smoothened suppresses intestinal tumorigenesis by down-regulation of Wnt signaling. | ||||||||||
| Author: | Arimura, Sumimasa|Matsunaga, Akihiro|Kitamura, Takanori|Aoki, Koji|Aoki, Masahiro|Taketo, Makoto M | ||||||||||
| PMID: | 19427313 | ||||||||||
| 10. | |||||||||||
| Journal: | J Gastroenterol. 2009;44(11):1113-7. | ||||||||||
| Title: | Sonic hedgehog relates to colorectal carcinogenesis. | ||||||||||
| Author: | Yoshikawa, Kozo|Shimada, Mitsuo|Miyamoto, Hidenori|Higashijima, Jun|Miyatani, Tomohiko|Nishioka, Masanori|Kurita, Nobuhiro|Iwata, Takashi|Uehara, Hisanori | ||||||||||
| PMID: | 19662327 | ||||||||||
| 11. | |||||||||||
| Journal: | PLoS One. 2009 Dec 21;4(12):e8357. | ||||||||||
| Title: | Analysis of the association between CIMP and BRAF in colorectal cancer by DNA methylation profiling. | ||||||||||
| Author: | Hinoue, Toshinori|Weisenberger, Daniel J|Pan, Fei|Campan, Mihaela|Kim, Myungjin|Young, Joanne|Whitehall, Vicki L|Leggett, Barbara A|Laird, Peter W | ||||||||||
| PMID: | 20027224 | ||||||||||
| 12. | |||||||||||
| Journal: | Mech Dev. 2010 Jan-Feb;127(1-2):73-81. | ||||||||||
| Title: | Hedgehog pathway activity is required for the lethality and intestinal phenotypes of mice with hyperactive Wnt signaling. | ||||||||||
| Author: | Varnat, Frederic|Zacchetti, Giovanna|Ruiz i Altaba, Ariel | ||||||||||
| PMID: | 19861162 | ||||||||||
| 13. | |||||||||||
| Journal: | Cancer Res. 2011 Feb 1;71(3):1092-102. | ||||||||||
| Title: | Hedgehog signaling drives cellular survival in human colon carcinoma cells. | ||||||||||
| Author: | Mazumdar, Tapati|DeVecchio, Jennifer|Shi, Ting|Jones, Janay|Agyeman, Akwasi|Houghton, Janet A | ||||||||||
| PMID: | 21135115 | ||||||||||
| 14. | |||||||||||
| Journal: | Hepatogastroenterology. 2011 Sep-Oct;58(110-111):1511-8. | ||||||||||
| Title: | Cyclopamine blocked the growth of colorectal cancer SW116 cells by modulating some target genes of Gli1 in vitro. | ||||||||||
| Author: | Wu, Jian-Ye|Xu, Xuan-Fu|Xu, Ling|Niu, Pei-Qin|Wang, Feng|Hu, Guo-Yong|Wang, Xing-Peng|Guo, Chuan-Yong | ||||||||||
| PMID: | 21940310 | ||||||||||
| 15. | |||||||||||
| Journal: | Oncotarget. 2011 Aug;2(8):638-45. | ||||||||||
| Title: | The GLI genes as the molecular switch in disrupting Hedgehog signaling in colon cancer. | ||||||||||
| Author: | Mazumdar, Tapati|DeVecchio, Jennifer|Agyeman, Akwasi|Shi, Ting|Houghton, Janet A | ||||||||||
| PMID: | 21860067 | ||||||||||
| 16. | |||||||||||
| Journal: | Cancer Res. 2011 Sep 1;71(17):5904-14. | ||||||||||
| Title: | Blocking Hedgehog survival signaling at the level of the GLI genes induces DNA damage and extensive cell death in human colon carcinoma cells. | ||||||||||
| Author: | Mazumdar, Tapati|Devecchio, Jennifer|Agyeman, Akwasi|Shi, Ting|Houghton, Janet A | ||||||||||
| PMID: | 21747117 | ||||||||||
| 17. | |||||||||||
| Journal: | Mol Carcinog. 2011 Nov;50(11):846-56. | ||||||||||
| Title: | Methyl-CpG binding column-based identification of nine genes hypermethylated in colorectal cancer. | ||||||||||
| Author: | Kober, Paulina|Bujko, Mateusz|Oledzki, Janusz|Tysarowski, Andrzej|Siedlecki, Janusz A | ||||||||||
| PMID: | 21438024 | ||||||||||
| 18. | |||||||||||
| Journal: | Mol Cancer Res. 2012 Sep;10(9):1147-57. | ||||||||||
| Title: | Inhibition of the hedgehog pathway targets the tumor-associated stroma in pancreatic cancer. | ||||||||||
| Author: | Hwang, Rosa F|Moore, Todd T|Hattersley, Maureen Mertens|Scarpitti, Meghan|Yang, Bin|Devereaux, Erik|Ramachandran, Vijaya|Arumugam, Thiruvengadam|Ji, Baoan|Logsdon, Craig D|Brown, Jeffrey L|Godin, Robert | ||||||||||
| PMID: | 22859707 | ||||||||||
| 19. | |||||||||||
| Journal: | Asian Pac J Cancer Prev. 2012;13(5):2319-24. | ||||||||||
| Title: | Expression and clinical significance of hedgehog signaling pathway related components in colorectal cancer. | ||||||||||
| Author: | Wang, Hong|Li, Yu-Yuan|Wu, Ying-Ying|Nie, Yu-Qiang | ||||||||||
| PMID: | 22901214 | ||||||||||
| 20. | |||||||||||
| Journal: | Nan Fang Yi Ke Da Xue Xue Bao. 2012 Aug;32(8):1098-104. | ||||||||||
| Title: | [Construction of has-microRNA-338-3p lentiviral vector and verification of its target gene]. | ||||||||||
| Author: | Deng, Haijun|Sun, Kai|Guo, Chen|Li, Ling|Li, Guoxin | ||||||||||
| PMID: | 22931599 | ||||||||||
| 21. | |||||||||||
| Journal: | Oncotarget. 2012 Aug;3(8):854-68. | ||||||||||
| Title: | Regulation of DNA damage following termination of Hedgehog (HH) survival signaling at the level of the GLI genes in human colon cancer. | ||||||||||
| Author: | Agyeman, Akwasi|Mazumdar, Tapati|Houghton, Janet A | ||||||||||
| PMID: | 23097684 | ||||||||||
| 22. | |||||||||||
| Journal: | Asian Pac J Cancer Prev. 2012;13(8):4001-5. | ||||||||||
| Title: | Expression of smoothened protein in colon cancer and its prognostic value for postoperative liver metastasis. | ||||||||||
| Author: | Ding, Yin-Lu|Wang, Qi-San|Zhao, Wei-Min|Xiang, Lei | ||||||||||
| PMID: | 23098507 | ||||||||||
| 23. | |||||||||||
| Journal: | Int J Cancer. 2013 Jan 15;132(2):E18-25. | ||||||||||
| Title: | Aberrant methylation of the PTCH1 gene promoter region in aberrant crypt foci. | ||||||||||
| Author: | Peng, Liang|Hu, Jingjing|Li, Shujun|Wang, Zhongqiu|Xia, Bingqing|Jiang, Bo|Li, Bingsheng|Zhang, Yu|Wang, Jing|Wang, Xinying | ||||||||||
| PMID: | 22945423 | ||||||||||
| 24. | |||||||||||
| Journal: | PLoS One. 2013 Jul 23;8(7):e69132. | ||||||||||
| Title: | Structural and logical analysis of a comprehensive hedgehog signaling pathway to identify alternative drug targets for glioma, colon and pancreatic cancer. | ||||||||||
| Author: | Chowdhury, Saikat|Pradhan, Rachana N|Sarkar, Ram Rup | ||||||||||
| PMID: | 23935937 | ||||||||||
| 25. | |||||||||||
| Journal: | World J Gastroenterol. 2013;19(14):2197-207. | ||||||||||
| Title: | miRNA-338-3p suppresses cell growth of human colorectal carcinoma by targeting smoothened. | ||||||||||
| Author: | Sun, Kai|Deng, Hai-Jun|Lei, Shang-Tong|Dong, Jing-Qing|Li, Guo-Xin | ||||||||||
| PMID: | 23599646 | ||||||||||
| 26. | |||||||||||
| Journal: | Acta Pharmacol Sin. 2013 Jan;34(1):167-75. | ||||||||||
| Title: | Construction of lentivirus-based inhibitor of hsa-microRNA-338-3p with specific secondary structure. | ||||||||||
| Author: | Sun, Kai|Guo, Chen|Deng, Hai-jun|Dong, Jing-qing|Lei, Shang-tong|Li, Guo-xin | ||||||||||
| PMID: | 23202799 | ||||||||||
| 27. | |||||||||||
| Journal: | Clin Epigenetics. 2013 Jan 16;5(1):2. | ||||||||||
| Title: | BRAF mutation-specific promoter methylation of FOX genes in colorectal cancer. | ||||||||||
| Author: | van Roon, Eddy H|Boot, Arnoud|Dihal, Ashwin A|Ernst, Robert F|van Wezel, Tom|Morreau, Hans|Boer, Judith M | ||||||||||
| PMID: | 23324568 | ||||||||||
| 28. | |||||||||||
| Journal: | Chin Med J (Engl). 2014;127(10):1884-90. | ||||||||||
| Title: | Relationship between miRNA-338-3p expression and progression and prognosis of human colorectal carcinoma. | ||||||||||
| Author: | Sun, Kai|Su, Guiyuan|Deng, Haijun|Dong, Jingqing|Lei, Shangtong|Li, Guoxin | ||||||||||
| PMID: | 24824250 | ||||||||||
| 29. | |||||||||||
| Journal: | Oncotarget. 2014 Jun 30;5(12):4492-503. | ||||||||||
| Title: | Mode and specificity of binding of the small molecule GANT61 to GLI determines inhibition of GLI-DNA binding. | ||||||||||
| Author: | Agyeman, Akwasi|Jha, Babal K|Mazumdar, Tapati|Houghton, Janet A | ||||||||||
| PMID: | 24962990 | ||||||||||
| 30. | |||||||||||
| Journal: | Ann Surg Oncol. 2014 Dec;21(13):4164-73. | ||||||||||
| Title: | SMO expression in colorectal cancer: associations with clinical, pathological, and molecular features. | ||||||||||
| Author: | Li, Tingting|Liao, Xiaoyun|Lochhead, Paul|Morikawa, Teppei|Yamauchi, Mai|Nishihara, Reiko|Inamura, Kentaro|Kim, Sun A|Mima, Kosuke|Sukawa, Yasutaka|Kuchiba, Aya|Imamura, Yu|Baba, Yoshifumi|Shima, Kaori|Meyerhardt, Jeffrey A|Chan, Andrew T|Fuchs, Charles S | ||||||||||
| PMID: | 25023548 | ||||||||||
| 31. | |||||||||||
| Journal: | Oncol Lett. 2014 Nov;8(5):2203-2208. | ||||||||||
| Title: | Hedgehog-glioma-associated oncogene homolog-1 signaling in colon cancer cells and its role in the celecoxib-mediated anti-cancer effect. | ||||||||||
| Author: | Wang, Hongtao|Ke, Fei|Zheng, Jie | ||||||||||
| PMID: | 25295109 | ||||||||||
| 32. | |||||||||||
| Journal: | PLoS One. 2015 Dec 17;10(12):e0144708. | ||||||||||
| Title: | Multi-Scale Genomic, Transcriptomic and Proteomic Analysis of Colorectal Cancer Cell Lines to Identify Novel Biomarkers. | ||||||||||
| Author: | Briffa, Romina|Um, Inhwa|Faratian, Dana|Zhou, Ying|Turnbull, Arran K|Langdon, Simon P|Harrison, David J | ||||||||||
| PMID: | 26678268 | ||||||||||
| 33. | |||||||||||
| Journal: | Int J Clin Exp Med. 2015 Nov 15;8(11):21379-85. eCollection 2015. | ||||||||||
| Title: | Dysregulation of hedgehog signaling pathway related components in the evolution of colonic carcinogenesis. | ||||||||||
| Author: | Zhang, Xu|Zhang, Sa-Sa|Wei, Gui-Jun|Deng, Zhong-Min|Hu, Yi | ||||||||||
| PMID: | 26885080 | ||||||||||
| 34. | |||||||||||
| Journal: | Oncol Res. 2016;24(3):137-44. | ||||||||||
| Title: | Knockdown of PFTAIRE Protein Kinase 1 (PFTK1) Inhibits Proliferation, Invasion, and EMT in Colon Cancer Cells. | ||||||||||
| Author: | Zhu, Jiankang|Liu, Chongzhong|Liu, Fengyue|Wang, Yadong|Zhu, Min | ||||||||||
| PMID: | 27458094 | ||||||||||
| 35. | |||||||||||
| Journal: | Iran J Basic Med Sci. 2016 Nov;19(11):1171-1176. | ||||||||||
| Title: | The hedgehog/Gli-1 signaling pathways is involved in the inhibitory effect of resveratrol on human colorectal cancer HCT116 cells. | ||||||||||
| Author: | Du, Zhou|Zhou, Feng|Jia, Zengrong|Zheng, Beishi|Han, Shaoliang|Cheng, Jun|Zhu, Guanbao|Huang, Ping | ||||||||||
| PMID: | 27917272 | ||||||||||
| 36. | |||||||||||
| Journal: | Mol Cancer. 2016 Oct 18;15(1):63. | ||||||||||
| Title: | Spatio-temporal mutation profiles of case-matched colorectal carcinomas and their metastases reveal unique de novo mutations in metachronous lung metastases by targeted next generation sequencing. | ||||||||||
| Author: | Kovaleva, Valentina|Geissler, Anna-Lena|Lutz, Lisa|Fritsch, Ralph|Makowiec, Frank|Wiesemann, Sebastian|Hopt, Ulrich T|Passlick, Bernward|Werner, Martin|Lassmann, Silke | ||||||||||
| PMID: | 27756406 | ||||||||||
| 37. | |||||||||||
| Journal: | Med Oncol. 2016 Oct;33(10):106. | ||||||||||
| Title: | Targeted molecular profiling of rare genetic alterations in colorectal cancer using next-generation sequencing. | ||||||||||
| Author: | Jauhri, Mayank|Bhatnagar, Akanksha|Gupta, Satish|Shokeen, Yogender|Minhas, Sachin|Aggarwal, Shyam | ||||||||||
| PMID: | 27568332 | ||||||||||
| 38. | |||||||||||
| Journal: | Hered Cancer Clin Pract. 2016 Aug 23;14(1):17. | ||||||||||
| Title: | Cytotoxic and targeted therapy for hereditary cancers. | ||||||||||
| Author: | Iyevleva, Aglaya G|Imyanitov, Evgeny N | ||||||||||
| PMID: | 27555886 | ||||||||||
| 39. | |||||||||||
| Journal: | Heliyon. 2016 May 11;2(5):e00109. | ||||||||||
| Title: | Neoexpression of a functional primary cilium in colorectal cancer cells. | ||||||||||
| Author: | Senicourt, Blanche|Boudjadi, Salah|Carrier, Julie C|Beaulieu, Jean-Francois | ||||||||||
| PMID: | 27441280 | ||||||||||
| 40. | |||||||||||
| Journal: | Exp Ther Med. 2017 May;13(5):2529-2536. | ||||||||||
| Title: | Smoothened antagonist GDC-0449 (Vismodegib) inhibits proliferation and triggers apoptosis in colon cancer cell lines. | ||||||||||
| Author: | Wu, Chuanqing|Hu, Shaobo|Cheng, Ji|Wang, Guobin|Tao, Kaixiong | ||||||||||
| PMID: | 28565875 | ||||||||||
| 41. | |||||||||||
| Journal: | Int J Mol Sci. 2017 Sep 1;18(9). pii: ijms18091888. | ||||||||||
| Title: | Bromopropane Compounds Increase the Stemness of Colorectal Cancer Cells. | ||||||||||
| Author: | Cho, Young-Chang|Nguyen, Thanh Thi|Park, So-Yeon|Kim, Kwonseop|Kim, Hyung Sik|Jeong, Hye Gwang|Kim, Kyung Keun|Kim, Hangun | ||||||||||
| PMID: | 28862656 | ||||||||||
| 42. | |||||||||||
| Journal: | Oncotarget. 2017 Oct 16;8(60):101952-101964. | ||||||||||
| Title: | Genipin suppresses colorectal cancer cells by inhibiting the Sonic Hedgehog pathway. | ||||||||||
| Author: | Kim, Bo Ram|Jeong, Yoon A|Na, Yoo Jin|Park, Seong Hye|Jo, Min Jee|Kim, Jung Lim|Jeong, Soyeon|Lee, Suk-Young|Kim, Hong Jun|Oh, Sang Cheul|Lee, Dae-Hee | ||||||||||
| PMID: | 29254217 | ||||||||||
| 43. | |||||||||||
| Journal: | Front Pharmacol. 2018 Feb 2;8:956. | ||||||||||
| Title: | SMO Inhibition Modulates Cellular Plasticity and Invasiveness in Colorectal Cancer. | ||||||||||
| Author: | Magistri, Paolo|Battistelli, Cecilia|Strippoli, Raffaele|Petrucciani, Niccolo|Pellinen, Teijo|Rossi, Lucia|Mangogna, Livia|Aurello, Paolo|D'Angelo, Francesco|Tripodi, Marco|Ramacciato, Giovanni|Nigri, Giuseppe | ||||||||||
| PMID: | 29456503 | ||||||||||
| 44. | |||||||||||
| Journal: | Biochem Biophys Res Commun. 2018 Sep 18;503(4):3198-3204. | ||||||||||
| Title: | The influence of aberrant expression of GLI1/p-S6K on colorectal cancer. | ||||||||||
| Author: | Wang, Xuchao|Yao, Yizhou|Zhu, Xinguo | ||||||||||
| PMID: | 30143258 | ||||||||||