Primary Site >> Colorectal Cancer
Gene >> SMO
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Ref: The patched/hedgehog/smoothened signalling pathway in human breast cancer: no evidence for H133Y SHH, PTCH and SMO mutations. PMID: 10505029 |
Ref: Functional Smoothened is required for expression of GLI3 in colorectal carcinoma cells. PMID: 15072830 Ref: Expression of Sonic hedgehog pathway genes is altered in colonic neoplasia. PMID: 15258993 Ref: Inhibitors of polyamine metabolism: review article. PMID: 15290341 |
Ref: Hedgehog signaling pathway and gastrointestinal stem cell signaling network (review). PMID: 17089004 |
Ref: Hedgehog signaling pathway is inactive in colorectal cancer cell lines. PMID: 17683069 Ref: [Effects of specific small interfering RNA on Smoothened expression and LoVo cell proliferation and apoptosis]. PMID: 17884791 |
Ref: HDAC3 impacts multiple oncogenic pathways in colon cancer cells with effects on Wnt and vitamin D signaling. PMID: 18769117 |
Ref: Reduced level of smoothened suppresses intestinal tumorigenesis by down-regulation of Wnt signaling. PMID: 19427313 Ref: Sonic hedgehog relates to colorectal carcinogenesis. PMID: 19662327 Ref: Analysis of the association between CIMP and BRAF in colorectal cancer by DNA methylation profiling. PMID: 20027224 |
Ref: Hedgehog pathway activity is required for the lethality and intestinal phenotypes of mice with hyperactive Wnt signaling. PMID: 19861162 |
Ref: Hedgehog signaling drives cellular survival in human colon carcinoma cells. PMID: 21135115 Ref: Methyl-CpG binding column-based identification of nine genes hypermethylated in colorectal cancer. PMID: 21438024 Ref: Blocking Hedgehog survival signaling at the level of the GLI genes induces DNA damage and extensive cell death in human colon carcinoma cells. PMID: 21747117 Ref: The GLI genes as the molecular switch in disrupting Hedgehog signaling in colon cancer. PMID: 21860067 Ref: Cyclopamine blocked the growth of colorectal cancer SW116 cells by modulating some target genes of Gli1 in vitro. PMID: 21940310 |
Ref: Inhibition of the hedgehog pathway targets the tumor-associated stroma in pancreatic cancer. PMID: 22859707 Ref: Expression and clinical significance of hedgehog signaling pathway related components in colorectal cancer. PMID: 22901214 Ref: [Construction of has-microRNA-338-3p lentiviral vector and verification of its target gene]. PMID: 22931599 Ref: Regulation of DNA damage following termination of Hedgehog (HH) survival signaling at the level of the GLI genes in human colon cancer. PMID: 23097684 Ref: Expression of smoothened protein in colon cancer and its prognostic value for postoperative liver metastasis. PMID: 23098507 |
Ref: Aberrant methylation of the PTCH1 gene promoter region in aberrant crypt foci. PMID: 22945423 Ref: Construction of lentivirus-based inhibitor of hsa-microRNA-338-3p with specific secondary structure. PMID: 23202799 Ref: BRAF mutation-specific promoter methylation of FOX genes in colorectal cancer. PMID: 23324568 Ref: miRNA-338-3p suppresses cell growth of human colorectal carcinoma by targeting smoothened. PMID: 23599646 Ref: Structural and logical analysis of a comprehensive hedgehog signaling pathway to identify alternative drug targets for glioma, colon and pancreatic cancer. PMID: 23935937 |
Ref: Relationship between miRNA-338-3p expression and progression and prognosis of human colorectal carcinoma. PMID: 24824250 Ref: Mode and specificity of binding of the small molecule GANT61 to GLI determines inhibition of GLI-DNA binding. PMID: 24962990 Ref: SMO expression in colorectal cancer: associations with clinical, pathological, and molecular features. PMID: 25023548 Ref: Hedgehog-glioma-associated oncogene homolog-1 signaling in colon cancer cells and its role in the celecoxib-mediated anti-cancer effect. PMID: 25295109 |
Ref: Multi-Scale Genomic, Transcriptomic and Proteomic Analysis of Colorectal Cancer Cell Lines to Identify Novel Biomarkers. PMID: 26678268 Ref: Dysregulation of hedgehog signaling pathway related components in the evolution of colonic carcinogenesis. PMID: 26885080 |
Ref: Neoexpression of a functional primary cilium in colorectal cancer cells. PMID: 27441280 Ref: Knockdown of PFTAIRE Protein Kinase 1 (PFTK1) Inhibits Proliferation, Invasion, and EMT in Colon Cancer Cells. PMID: 27458094 Ref: Cytotoxic and targeted therapy for hereditary cancers. PMID: 27555886 Ref: Targeted molecular profiling of rare genetic alterations in colorectal cancer using next-generation sequencing. PMID: 27568332 Ref: Spatio-temporal mutation profiles of case-matched colorectal carcinomas and their metastases reveal unique de novo mutations in metachronous lung metastases by targeted next generation sequencing. PMID: 27756406 Ref: The hedgehog/Gli-1 signaling pathways is involved in the inhibitory effect of resveratrol on human colorectal cancer HCT116 cells. PMID: 27917272 |
Ref: Smoothened antagonist GDC-0449 (Vismodegib) inhibits proliferation and triggers apoptosis in colon cancer cell lines. PMID: 28565875 Ref: Bromopropane Compounds Increase the Stemness of Colorectal Cancer Cells. PMID: 28862656 Ref: Genipin suppresses colorectal cancer cells by inhibiting the Sonic Hedgehog pathway. PMID: 29254217 Ref: SMO Inhibition Modulates Cellular Plasticity and Invasiveness in Colorectal Cancer. PMID: 29456503 |
Ref: The influence of aberrant expression of GLI1/p-S6K on colorectal cancer. PMID: 30143258 |