Literatures

Primary Site >> Pancreatic Cancer

Gene >> SMAD4

1.
Journal:	Science. 1996 Jan 19;271(5247):350-3.
Title:	DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1.
Author:	Hahn, S A\|Schutte, M\|Hoque, A T\|Moskaluk, C A\|da Costa, L T\|Rozenblum, E\|Weinstein, C L\|Fischer, A\|Yeo, C J\|Hruban, R H\|Kern, S E
PMID:	8553070

2.
Journal:	Cancer Res. 1996 Feb 1;56(3):490-4.
Title:	Homozygous deletion map at 18q21.1 in pancreatic cancer.
Author:	Hahn, S A\|Hoque, A T\|Moskaluk, C A\|da Costa, L T\|Schutte, M\|Rozenblum, E\|Seymour, A B\|Weinstein, C L\|Yeo, C J\|Hruban, R H\|Kern, S E
PMID:	8564959

3.
Journal:	Nature. 1996 Jun 13;381(6583):620-3.
Title:	A human Mad protein acting as a BMP-regulated transcriptional activator.
Author:	Liu, F\|Hata, A\|Baker, J C\|Doody, J\|Carcamo, J\|Harland, R M\|Massague, J
PMID:	8637600

4.
Journal:	Cancer Res. 1996 Jun 1;56(11):2519-21.
Title:	DPC4, a candidate tumor suppressor gene, is altered infrequently in head and neck squamous cell carcinoma.
Author:	Kim, S K\|Fan, Y\|Papadimitrakopoulou, V\|Clayman, G\|Hittelman, W N\|Hong, W K\|Lotan, R\|Mao, L
PMID:	8653689

5.
Journal:	Cancer Res. 1996 Jun 1;56(11):2527-30.
Title:	DPC4 gene in various tumor types.
Author:	Schutte, M\|Hruban, R H\|Hedrick, L\|Cho, K R\|Nadasdy, G M\|Weinstein, C L\|Bova, G S\|Isaacs, W B\|Cairns, P\|Nawroz, H\|Sidransky, D\|Casero, R A Jr\|Meltzer, P S\|Hahn, S A\|Kern, S E
PMID:	8653691

6.
Journal:	Cell. 1996 Aug 23;86(4):543-52.
Title:	MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma.
Author:	Eppert, K\|Scherer, S W\|Ozcelik, H\|Pirone, R\|Hoodless, P\|Kim, H\|Tsui, L C\|Bapat, B\|Gallinger, S\|Andrulis, I L\|Thomsen, G H\|Wrana, J L\|Attisano, L
PMID:	8752209

7.
Journal:	Gastroenterology. 1996 Nov;111(5):1369-72.
Title:	Somatic alterations of the DPC4 gene in human colorectal cancers in vivo.
Author:	Takagi, Y\|Kohmura, H\|Futamura, M\|Kida, H\|Tanemura, H\|Shimokawa, K\|Saji, S
PMID:	8898652

8.
Journal:	Oncogene. 1996 Dec 5;13(11):2459-62.
Title:	Infrequent DPC4 gene mutation in esophageal cancer, gastric cancer and ulcerative colitis-associated neoplasms.
Author:	Lei, J\|Zou, T T\|Shi, Y Q\|Zhou, X\|Smolinski, K N\|Yin, J\|Souza, R F\|Appel, R\|Wang, S\|Cymes, K\|Chan, O\|Abraham, J M\|Harpaz, N\|Meltzer, S J
PMID:	8957088

9.
Journal:	Diagn Mol Pathol. 1997 Apr;6(2):85-90.
Title:	Genomic sequencing of DPC4 in the analysis of familial pancreatic carcinoma.
Author:	Moskaluk, C A\|Hruban, R H\|Schutte, M\|Lietman, A S\|Smyrk, T\|Fusaro, L\|Fusaro, R\|Lynch, J\|Yeo, C J\|Jackson, C E\|Lynch, H T\|Kern, S E
PMID:	9098646

10.
Journal:	Mol Cell Biol. 1997 May;17(5):2521-8.
Title:	Heteromeric and homomeric interactions correlate with signaling activity and functional cooperativity of Smad3 and Smad4/DPC4.
Author:	Wu, R Y\|Zhang, Y\|Feng, X H\|Derynck, R
PMID:	9111321

11.
Journal:	Cancer Res. 1997 May 1;57(9):1731-4.
Title:	Tumor-suppressive pathways in pancreatic carcinoma.
Author:	Rozenblum, E\|Schutte, M\|Goggins, M\|Hahn, S A\|Panzer, S\|Zahurak, M\|Goodman, S N\|Sohn, T A\|Hruban, R H\|Yeo, C J\|Kern, S E
PMID:	9135016

12.
Journal:	Jpn J Cancer Res. 1997 Apr;88(4):335-9.
Title:	Analysis of the DPC4 gene in gastric carcinoma.
Author:	Nishizuka, S\|Tamura, G\|Maesawa, C\|Sakata, K\|Suzuki, Y\|Iwaya, T\|Terashima, M\|Saito, K\|Satodate, R
PMID:	9197522

13.
Journal:	J Clin Lab Anal. 1997;11(4):225-31.
Title:	Molecular diagnosis of pancreas carcinoma.
Author:	Chu, T M
PMID:	9219065

14.
Journal:	Nihon Geka Gakkai Zasshi. 1997 Jul;98(7):597-603.
Title:	[Molecular diagnosis of pancreatic cancer].
Author:	Sugano, K
PMID:	9276865

15.
Journal:	Cancer Res. 1997 Sep 1;57(17):3772-8.
Title:	Expression and mutational analysis of the DCC, DPC4, and MADR2/JV18-1 genes in neuroblastoma.
Author:	Kong, X T\|Choi, S H\|Inoue, A\|Xu, F\|Chen, T\|Takita, J\|Yokota, J\|Bessho, F\|Yanagisawa, M\|Hanada, R\|Yamamoto, K\|Hayashi, Y
PMID:	9288786

16.
Journal:	Cancer Res. 1997 Sep 15;57(18):3929-34.
Title:	Induction of p21waf1 expression and growth inhibition by transforming growth factor beta involve the tumor suppressor gene DPC4 in human pancreatic adenocarcinoma cells.
Author:	Grau, A M\|Zhang, L\|Wang, W\|Ruan, S\|Evans, D B\|Abbruzzese, J L\|Zhang, W\|Chiao, P J
PMID:	9307274

17.
Journal:	J Biol Chem. 1997 Oct 3;272(40):24731-4.
Title:	Induction of apoptosis by DPC4, a transcriptional factor regulated by transforming growth factor-beta through stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) signaling pathway.
Author:	Atfi, A\|Buisine, M\|Mazars, A\|Gespach, C
PMID:	9312063

18.
Journal:	Cancer Res. 1997 Oct 1;57(19):4221-4.
Title:	Inactivation of Smad4 in gastric carcinomas.
Author:	Powell, S M\|Harper, J C\|Hamilton, S R\|Robinson, C R\|Cummings, O W
PMID:	9331080

19.
Journal:	Genes Dev. 1997 Dec 1;11(23):3157-67.
Title:	Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes.
Author:	Liu, F\|Pouponnot, C\|Massague, J
PMID:	9389648

20.
Journal:	Digestion. 1997;58(6):550-6.
Title:	Molecular advances in pancreatic cancer.
Author:	Lemoine, N R
PMID:	9438601

21.
Journal:	Genes Dev. 1998 Jan 1;12(1):107-19.
Title:	The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo.
Author:	Sirard, C\|de la Pompa, J L\|Elia, A\|Itie, A\|Mirtsos, C\|Cheung, A\|Hahn, S\|Wakeham, A\|Schwartz, L\|Kern, S E\|Rossant, J\|Mak, T W
PMID:	9420335

22.
Journal:	Surg Oncol Clin N Am. 1998 Jan;7(1):1-23.
Title:	Genetics of pancreatic cancer. From genes to families.
Author:	Hruban, R H\|Petersen, G M\|Ha, P K\|Kern, S E
PMID:	9443984

23.
Journal:	Surg Oncol Clin N Am. 1998 Jan;7(1):25-41.
Title:	Role of growth factors in pancreatic cancer.
Author:	Korc, M
PMID:	9443985

24.
Journal:	J Biol Chem. 1998 Mar 27;273(13):7495-500.
Title:	Up-regulation of transforming growth factor (TGF)-beta receptors by TGF-beta1 in COLO-357 cells.
Author:	Kleeff, J\|Korc, M
PMID:	9516449

25.
Journal:	Cancer Res. 1998 Jun 1;58(11):2339-42.
Title:	Alterations in pancreatic, biliary, and breast carcinomas support MKK4 as a genetically targeted tumor suppressor gene.
Author:	Su, G H\|Hilgers, W\|Shekher, M C\|Tang, D J\|Yeo, C J\|Hruban, R H\|Kern, S E
PMID:	9622070

26.
Journal:	Langenbecks Arch Surg. 1998 Apr;383(2):105-15.
Title:	Molecular pattern of ductal pancreatic cancer.
Author:	Sirivatanauksorn, V\|Sirivatanauksorn, Y\|Lemoine, N R
PMID:	9641882

27.
Journal:	Leukemia. 1998 Jul;12(7):1114-8.
Title:	Mutational analysis of the tumor suppressor Smad2 in acute lymphoid and myeloid leukemia.
Author:	Wieser, R\|Gruber, B\|Rieder, H\|Fonatsch, C
PMID:	9665198

28.
Journal:	Br J Cancer. 1998 Jun;77(11):1893-9.
Title:	Cytogenetic and FISH analyses of pancreatic carcinoma reveal breaks in 18q11 with consistent loss of 18q12-qter and frequent gain of 18p.
Author:	Hoglund, M\|Gorunova, L\|Jonson, T\|Dawiskiba, S\|Andren-Sandberg, A\|Stenman, G\|Johansson, B
PMID:	9667665

29.
Journal:	Digestion. 1998 Aug;59(5):493-501.
Title:	Recent discoveries in cancer genetics of exocrine pancreatic neoplasia.
Author:	Hahn, S A\|Schmiegel, W H
PMID:	9705534

30.
Journal:	Scand J Work Environ Health. 1998 Jun;24(3):165-74.
Title:	Occurrence, trends and environment etiology of pancreatic cancer.
Author:	Weiderpass, E\|Partanen, T\|Kaaks, R\|Vainio, H\|Porta, M\|Kauppinen, T\|Ojajarvi, A\|Boffetta, P\|Malats, N
PMID:	9710368

31.
Journal:	Int J Cancer. 1998 Oct 5;78(2):255-60.
Title:	Transfection of the type I TGF-beta receptor restores TGF-beta responsiveness in pancreatic cancer.
Author:	Wagner, M\|Kleeff, J\|Lopez, M E\|Bockman, I\|Massaque, J\|Korc, M
PMID:	9754660

32.
Journal:	Oncogene. 1998 Oct 15;17(15):1969-78.
Title:	Disruption of the antiproliferative TGF-beta signaling pathways in human pancreatic cancer cells.
Author:	Villanueva, A\|Garcia, C\|Paules, A B\|Vicente, M\|Megias, M\|Reyes, G\|de Villalonga, P\|Agell, N\|Lluis, F\|Bachs, O\|Capella, G
PMID:	9788440

33.
Journal:	Crit Rev Eukaryot Gene Expr. 1998;8(3-4):377-93.
Title:	The molecular and cellular biology of pancreatic cancer.
Author:	Perugini, R A\|McDade, T P\|Vittimberga, F J Jr\|Callery, M P
PMID:	9807701

34.
Journal:	Cancer Res. 1998 Dec 1;58(23):5329-32.
Title:	Genetic alterations of the transforming growth factor beta receptor genes in pancreatic and biliary adenocarcinomas.
Author:	Goggins, M\|Shekher, M\|Turnacioglu, K\|Yeo, C J\|Hruban, R H\|Kern, S E
PMID:	9850059

35.
Journal:	Bull Cancer. 1998 Oct;85(10):832.
Title:	[SMAD4/DPC4 (small mothers against decapentaplegic deleted in pancreatic carcinoma, locus 4). Tumor suppressor gene].
Author:
PMID:	9867367

36.
Journal:	Genes Chromosomes Cancer. 1999 Jan;24(1):62-71.
Title:	Molecular analyses of the 15q and 18q SMAD genes in pancreatic cancer.
Author:	Jonson, T\|Gorunova, L\|Dawiskiba, S\|Andren-Sandberg, A\|Stenman, G\|ten Dijke, P\|Johansson, B\|Hoglund, M
PMID:	9892110

37.
Journal:	J Biol Chem. 1999 Apr 2;274(14):9431-41.
Title:	Cooperative binding of Smad proteins to two adjacent DNA elements in the plasminogen activator inhibitor-1 promoter mediates transforming growth factor beta-induced smad-dependent transcriptional activation.
Author:	Stroschein, S L\|Wang, W\|Luo, K
PMID:	10092624

38.
Journal:	Pancreas. 1999 Apr;18(3):308-15.
Title:	Immunohistochemical and molecular analysis of giant cell carcinoma of the pancreas: a report of three cases.
Author:	Imai, Y\|Morishita, S\|Ikeda, Y\|Toyoda, M\|Ashizawa, T\|Yamamoto, K\|Inoue, T\|Ishikawa, T
PMID:	10206490

39.
Journal:	Gastroenterology. 1999 May;116(5):1202-16.
Title:	Bone morphogenetic protein 2 exerts diverse effects on cell growth in vitro and is expressed in human pancreatic cancer in vivo.
Author:	Kleeff, J\|Maruyama, H\|Ishiwata, T\|Sawhney, H\|Friess, H\|Buchler, M W\|Korc, M
PMID:	10220513

40.
Journal:	Pancreas. 1999 May;18(4):364-70.
Title:	Ligand induced upregulation of the type II transforming growth factor (TGF-beta) receptor enhances TGF-beta responsiveness in COLO-357 cells.
Author:	Kleeff, J\|Wildi, S\|Friess, H\|Korc, M
PMID:	10231841

41.
Journal:	Oncogene. 1999 Apr 8;18(14):2367-71.
Title:	Mutations of the DPC4/Smad4 gene in neuroendocrine pancreatic tumors.
Author:	Bartsch, D\|Hahn, S A\|Danichevski, K D\|Ramaswamy, A\|Bastian, D\|Galehdari, H\|Barth, P\|Schmiegel, W\|Simon, B\|Rothmund, M
PMID:	10327057

42.
Journal:	Oncogene. 1999 May 20;18(20):3152-8.
Title:	DPC4/SMAD4 mediated tumor suppression of colon carcinoma cells is associated with reduced urokinase expression.
Author:	Schwarte-Waldhoff, I\|Klein, S\|Blass-Kampmann, S\|Hintelmann, A\|Eilert, C\|Dreschers, S\|Kalthoff, H\|Hahn, S A\|Schmiegel, W
PMID:	10340387

43.
Journal:	Cancer. 1999 Jun 1;85(11):2352-8.
Title:	Malignant fibrous histiocytoma of the pancreas: a case report with genetic analysis.
Author:	Bastian, D\|Ramaswamy, A\|Barth, P J\|Gerdes, B\|Ernst, M\|Bartsch, D
PMID:	10357405

44.
Journal:	Eur J Surg. 1999 Apr;165(4):292-306.
Title:	Prognosis of human pancreatic adenocarcinoma: review of clinical and histopathological variables and possible uses of new molecular methods.
Author:	Eskelinen, M J\|Haglund, U H
PMID:	10365829

45.
Journal:	Cancer Lett. 1999 May 3;139(1):43-9.
Title:	Higher frequency of DPC4/Smad4 alterations in pancreatic cancer cell lines than in primary pancreatic adenocarcinomas.
Author:	Bartsch, D\|Barth, P\|Bastian, D\|Ramaswamy, A\|Gerdes, B\|Chaloupka, B\|Deiss, Y\|Simon, B\|Schudy, A
PMID:	10408907

46.
Journal:	Ann N Y Acad Sci. 1999 Jun 30;880:31-7.
Title:	Tumor suppressor gene Smad4/DPC4, its downstream target genes, and regulation of cell cycle.
Author:	Chiao, P J\|Hunt, K K\|Grau, A M\|Abramian, A\|Fleming, J\|Zhang, W\|Breslin, T\|Abbruzzese, J L\|Evans, D B
PMID:	10415848

47.
Journal:	Ann N Y Acad Sci. 1999 Jun 30;880:74-82.
Title:	Molecular pathology of invasive carcinoma.
Author:	Longnecker, D S
PMID:	10415852

48.
Journal:	Ann N Y Acad Sci. 1999 Jun 30;880:103-9.
Title:	Orthotopic models of human pancreatic cancer.
Author:	Capella, G\|Farre, L\|Villanueva, A\|Reyes, G\|Garcia, C\|Tarafa, G\|Lluis, F
PMID:	10415855

49.
Journal:	Ann N Y Acad Sci. 1999 Jun 30;880:110-21.
Title:	Growth factors and cytokines in pancreatic carcinogenesis.
Author:	Friess, H\|Guo, X Z\|Nan, B C\|Kleeff, J\|Buchler, M W
PMID:	10415856

50.
Journal:	Ann Oncol. 1999;10 Suppl 4:4-8.
Title:	Progress in cancer genetics: lessons from pancreatic cancer.
Author:	Goggins, M\|Kern, S E\|Offerhaus, J A\|Hruban, R H
PMID:	10436774

51.
Journal:	Ann Oncol. 1999;10 Suppl 4:56-9.
Title:	DPC4/SMAD4 gene alterations in human cancer, and their functional implications.
Author:	Schutte, M
PMID:	10436786

52.
Journal:	Ann Oncol. 1999;10 Suppl 4:153-6.
Title:	Biliopancreatic malignancy: screening the at risk patient with molecular markers.
Author:	Caldas, C
PMID:	10436811

53.
Journal:	Dig Surg. 1999;16(4):281-90.
Title:	Molecular aspects of pancreatic cancer and future perspectives.
Author:	Friess, H\|Kleeff, J\|Korc, M\|Buchler, M W
PMID:	10449972

54.
Journal:	Mutat Res. 1999 Aug;406(2-4):71-7.
Title:	Inactivation of both alleles of the DPC4/SMAD4 gene in advanced colorectal cancers: identification of seven novel somatic mutations in tumors from Japanese patients.
Author:	Koyama, M\|Ito, M\|Nagai, H\|Emi, M\|Moriyama, Y
PMID:	10479724

55.
Journal:	Mol Carcinog. 1999 Sep;26(1):37-43.
Title:	Transforming growth factor-beta responsiveness in DPC4/SMAD4-null cancer cells.
Author:	Dai, J L\|Schutte, M\|Bansal, R K\|Wilentz, R E\|Sugar, A Y\|Kern, S E
PMID:	10487520

56.
Journal:	Oncogene. 1999 Sep 23;18(39):5363-72.
Title:	The TGF-beta signaling inhibitor Smad7 enhances tumorigenicity in pancreatic cancer.
Author:	Kleeff, J\|Ishiwata, T\|Maruyama, H\|Friess, H\|Truong, P\|Buchler, M W\|Falb, D\|Korc, M
PMID:	10498890

57.
Journal:	Dig Dis Sci. 1999 Sep;44(9):1793-802.
Title:	Overexpression of Smad2 and colocalization with TGF-beta1 in human pancreatic cancer.
Author:	Kleeff, J\|Friess, H\|Simon, P\|Susmallian, S\|Buchler, P\|Zimmermann, A\|Buchler, M W\|Korc, M
PMID:	10505717

58.
Journal:	Cancer Res. 1999 Dec 15;59(24):6113-7.
Title:	Gastric and duodenal polyps in Smad4 (Dpc4) knockout mice.
Author:	Takaku, K\|Miyoshi, H\|Matsunaga, A\|Oshima, M\|Sasaki, N\|Taketo, M M
PMID:	10626800

59.
Journal:	Ann N Y Acad Sci. 1999;886:73-82.
Title:	Intracellular signaling of the TGF-beta superfamily by Smad proteins.
Author:	Kawabata, M\|Imamura, T\|Inoue, H\|Hanai, J\|Nishihara, A\|Hanyu, A\|Takase, M\|Ishidou, Y\|Udagawa, Y\|Oeda, E\|Goto, D\|Yagi, K\|Kato, M\|Miyazono, K
PMID:	10667205

60.
Journal:	Curr Opin Gastroenterol. 1999 Sep;15(5):404-9.
Title:	Molecular genetics and related developments in pancreatic cancer.
Author:	Hruban, R H\|Goggins, M\|Kern, S E
PMID:	17023981

61.
Journal:	Am J Pathol. 2000 Jan;156(1):37-43.
Title:	Immunohistochemical labeling for dpc4 mirrors genetic status in pancreatic adenocarcinomas : a new marker of DPC4 inactivation.
Author:	Wilentz, R E\|Su, G H\|Dai, J L\|Sparks, A B\|Argani, P\|Sohn, T A\|Yeo, C J\|Kern, S E\|Hruban, R H
PMID:	10623651

62.
Journal:	Oncogene. 2000 Jan 27;19(4):546-55.
Title:	DCC and SMAD4 alterations in human colorectal and pancreatic tumor dissemination.
Author:	Tarafa, G\|Villanueva, A\|Farre, L\|Rodriguez, J\|Musulen, E\|Reyes, G\|Seminago, R\|Olmedo, E\|Paules, A B\|Peinado, M A\|Bachs, O\|Capella, G
PMID:	10698524

63.
Journal:	Genes Chromosomes Cancer. 2000 Apr;27(4):353-7.
Title:	Homozygous deletions inactivate DCC, but not MADH4/DPC4/SMAD4, in a subset of pancreatic and biliary cancers.
Author:	Hilgers, W\|Song, J J\|Haye, M\|Hruban, R R\|Kern, S E\|Fearon, E R
PMID:	10719364

64.
Journal:	Nihon Geka Gakkai Zasshi. 2000 Feb;101(2):233-6.
Title:	[General rules for the study of pancreatic cancer by molecular biological aspect].
Author:	Omata, M\|Tada, M
PMID:	10734643

65.
Journal:	Am J Physiol Gastrointest Liver Physiol. 2000 Apr;278(4):G513-21.
Title:	TIEG proteins join the Smads as TGF-beta-regulated transcription factors that control pancreatic cell growth.
Author:	Cook, T\|Urrutia, R
PMID:	10762604

66.
Journal:	Cancer Res. 2000 Apr 1;60(7):2002-6.
Title:	Loss of expression of Dpc4 in pancreatic intraepithelial neoplasia: evidence that DPC4 inactivation occurs late in neoplastic progression.
Author:	Wilentz, R E\|Iacobuzio-Donahue, C A\|Argani, P\|McCarthy, D M\|Parsons, J L\|Yeo, C J\|Kern, S E\|Hruban, R H
PMID:	10766191

67.
Journal:	Anticancer Res. 2000 Jan-Feb;20(1A):43-51.
Title:	Differential expression of transforming growth factor beta receptors in human pancreatic adenocarcinoma.
Author:	Venkatasubbarao, K\|Ahmed, M M\|Mohiuddin, M\|Swiderski, C\|Lee, E\|Gower, W R Jr\|Salhab, K F\|McGrath, P\|Strodel, W\|Freeman, J W
PMID:	10769633

68.
Journal:	Oncogene. 2000 Apr 6;19(15):1868-74.
Title:	Haploid loss of the tumor suppressor Smad4/Dpc4 initiates gastric polyposis and cancer in mice.
Author:	Xu, X\|Brodie, S G\|Yang, X\|Im, Y H\|Parks, W T\|Chen, L\|Zhou, Y X\|Weinstein, M\|Kim, S J\|Deng, C X
PMID:	10773876

69.
Journal:	Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4820-5.
Title:	Mutations in the tumor suppressors Smad2 and Smad4 inactivate transforming growth factor beta signaling by targeting Smads to the ubiquitin-proteasome pathway.
Author:	Xu, J\|Attisano, L
PMID:	10781087

70.
Journal:	Int J Cancer. 2000 May 15;86(4):529-32.
Title:	Germline mutations of the dpc4 gene in Korean juvenile polyposis patients.
Author:	Kim, I J\|Ku, J L\|Yoon, K A\|Heo, S C\|Jeong, S Y\|Choi, H S\|Hong, K H\|Yang, S K\|Park, J G
PMID:	10797267

71.
Journal:	Anticancer Res. 2000 Mar-Apr;20(2A):729-33.
Title:	Anomalies of the TGF-beta postreceptor signaling pathway in ovarian cancer cell lines.
Author:	Hu, W\|Wu, W\|Nash, M A\|Freedman, R S\|Kavanagh, J J\|Verschraegen, C F
PMID:	10810347

72.
Journal:	Cancer. 2000 May 1;88(9):2010-21.
Title:	Characterization of a newly established human pancreatic carcinoma cell line, UK Pan-1.
Author:	Fralix, K D\|Ahmed, M M\|Mattingly, C\|Swiderski, C\|McGrath, P C\|Venkatasubbarao, K\|Kamada, N\|Mohiuddin, M\|Strodel, W E\|Freeman, J W
PMID:	10813711

73.
Journal:	Ann Surg. 2000 Jul;232(1):73-80.
Title:	Disruption of TGFbeta signaling pathways in human pancreatic cancer cells.
Author:	Simeone, D M\|Pham, T\|Logsdon, C D
PMID:	10862198

74.
Journal:	Am J Pathol. 2000 Jul;157(1):83-92.
Title:	Molecular analysis of microdissected tumors and preneoplastic intraductal lesions in pancreatic carcinoma.
Author:	Heinmoller, E\|Dietmaier, W\|Zirngibl, H\|Heinmoller, P\|Scaringe, W\|Jauch, K W\|Hofstadter, F\|Ruschoff, J
PMID:	10880379

75.
Journal:	Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9624-9.
Title:	Smad4/DPC4-mediated tumor suppression through suppression of angiogenesis.
Author:	Schwarte-Waldhoff, I\|Volpert, O V\|Bouck, N P\|Sipos, B\|Hahn, S A\|Klein-Scory, S\|Luttges, J\|Kloppel, G\|Graeven, U\|Eilert-Micus, C\|Hintelmann, A\|Schmiegel, W
PMID:	10944227

76.
Journal:	Am J Gastroenterol. 2000 Aug;95(8):2080-5.
Title:	Association of poor prognosis with loss of 12q, 17p, and 18q, and concordant loss of 6q/17p and 12q/18q in human pancreatic ductal adenocarcinoma.
Author:	Yatsuoka, T\|Sunamura, M\|Furukawa, T\|Fukushige, S\|Yokoyama, T\|Inoue, H\|Shibuya, K\|Takeda, K\|Matsuno, S\|Horii, A
PMID:	10950061

77.
Journal:	Pancreas. 2000 Aug;21(2):152-7.
Title:	Reassessment of K-ras mutations at codon 12 by direct PCR and sequencing from tissue microdissection in human pancreatic adenocarcinomas.
Author:	Aoki, Y\|Hosaka, S\|Tachibana, N\|Karasawa, Y\|Kawa, S\|Kiyosawa, K
PMID:	10975709

78.
Journal:	Am J Pathol. 2000 Sep;157(3):755-61.
Title:	Dpc-4 protein is expressed in virtually all human intraductal papillary mucinous neoplasms of the pancreas: comparison with conventional ductal adenocarcinomas.
Author:	Iacobuzio-Donahue, C A\|Klimstra, D S\|Adsay, N V\|Wilentz, R E\|Argani, P\|Sohn, T A\|Yeo, C J\|Cameron, J L\|Kern, S E\|Hruban, R H
PMID:	10980115

79.
Journal:	Br J Cancer. 2000 Oct;83(8):1015-9.
Title:	No SMAD4 hypermethylation in colorectal cancer.
Author:	Roth, S\|Laiho, P\|Salovaara, R\|Launonen, V\|Aaltonen, L A
PMID:	10993648

80.
Journal:	Oncogene. 2000 Sep 14;19(39):4531-41.
Title:	TGFbeta1 represses proliferation of pancreatic carcinoma cells which correlates with Smad4-independent inhibition of ERK activation.
Author:	Giehl, K\|Seidel, B\|Gierschik, P\|Adler, G\|Menke, A
PMID:	11002426

81.
Journal:	Biochim Biophys Acta. 2000 Oct 18;1502(2):283-96.
Title:	The 18q21 region in colorectal and pancreatic cancer: independent loss of DCC and DPC4 expression.
Author:	Barbera, V M\|Martin, M\|Marinoso, L\|Munne, A\|Carrato, A\|Real, F X\|Fabre, M
PMID:	11040453

82.
Journal:	Am J Surg Pathol. 2000 Nov;24(11):1544-8.
Title:	Dpc4 protein in mucinous cystic neoplasms of the pancreas: frequent loss of expression in invasive carcinomas suggests a role in genetic progression.
Author:	Iacobuzio-Donahue, C A\|Wilentz, R E\|Argani, P\|Yeo, C J\|Cameron, J L\|Kern, S E\|Hruban, R H
PMID:	11075857

83.
Journal:	Swiss Surg. 2000;6(5):231-4.
Title:	Pancreatic cancer--new aspects of molecular biology research.
Author:	Kleeff, J\|Friess, H\|Berberat, P O\|Martignoni, M E\|Z'graggen, K\|Buchler, M W
PMID:	11077487

84.
Journal:	Zhonghua Bing Li Xue Za Zhi. 2000 Aug;29(4):256-8.
Title:	[Detection of alterations of the DPC4 gene in paraffin-embedded tissues of pancreatic carcinomas].
Author:	Gu, L\|Cui, Q\|Chen, J\|Li, L\|Liu, T
PMID:	11866919

85.
Journal:	Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 2000;32(3):239-242.
Title:	Expression of Smad4 Gene in Pichia pastoris and Identification of the Protein.
Author:	Liu, Yi-Ping\|Yang, Xiao\|Xu, Xiao-Ling\|Deng, Ji-Xian\|Cheng, Xuan\|Huang, Cui-Fen
PMID:	12075447

86.
Journal:	Curr Opin Gastroenterol. 2000 Sep;16(5):419-25.
Title:	Molecular genetics of ductal pancreatic neoplasia.
Author:	Su, G H\|Kern, S E
PMID:	17031113

87.
Journal:	Oncol Rep. 2001 Jan-Feb;8(1):89-92.
Title:	Characterization of the mutations of the K-ras, p53, p16, and SMAD4 genes in 15 human pancreatic cancer cell lines.
Author:	Sun, C\|Yamato, T\|Furukawa, T\|Ohnishi, Y\|Kijima, H\|Horii, A
PMID:	11115575

88.
Journal:	Teratog Carcinog Mutagen. 2001;21(1):27-44.
Title:	Growth factors and their receptors in pancreatic cancer.
Author:	Ozawa, F\|Friess, H\|Tempia-Caliera, A\|Kleeff, J\|Buchler, M W
PMID:	11135319

89.
Journal:	Genes Dev. 2001 Feb 1;15(3):286-93.
Title:	A murine tumor progression model for pancreatic cancer recapitulating the genetic alterations of the human disease.
Author:	Wagner, M\|Greten, F R\|Weber, C K\|Koschnick, S\|Mattfeldt, T\|Deppert, W\|Kern, H\|Adler, G\|Schmid, R M
PMID:	11159909

90.
Journal:	Br J Cancer. 2001 Jan;84(2):253-62.
Title:	Pancreatic tumours: molecular pathways implicated in ductal cancer are involved in ampullary but not in exocrine nonductal or endocrine tumorigenesis.
Author:	Moore, P S\|Orlandini, S\|Zamboni, G\|Capelli, P\|Rigaud, G\|Falconi, M\|Bassi, C\|Lemoine, N R\|Scarpa, A
PMID:	11161385

91.
Journal:	Int J Cancer. 2001 Feb 1;91(3):350-8.
Title:	Non-random chromosomal rearrangements in pancreatic cancer cell lines identified by spectral karyotyping.
Author:	Sirivatanauksorn, V\|Sirivatanauksorn, Y\|Gorman, P A\|Davidson, J M\|Sheer, D\|Moore, P S\|Scarpa, A\|Edwards, P A\|Lemoine, N R
PMID:	11169959

92.
Journal:	Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3254-7.
Title:	ACVR1B (ALK4, activin receptor type 1B) gene mutations in pancreatic carcinoma.
Author:	Su, G H\|Bansal, R\|Murphy, K M\|Montgomery, E\|Yeo, C J\|Hruban, R H\|Kern, S E
PMID:	11248065

93.
Journal:	J Biol Chem. 2001 Apr 20;276(16):13461-8. Epub 2001 Jan 22.
Title:	Transcriptional activation of mouse sst2 somatostatin receptor promoter by transforming growth factor-beta. Involvement of Smad4.
Author:	Puente, E\|Saint-Laurent, N\|Torrisani, J\|Furet, C\|Schally, A V\|Vaysse, N\|Buscail, L\|Susini, C
PMID:	11278805

94.
Journal:	Ann Surg. 2001 May;233(5):696-703.
Title:	High-throughput drug screening of the DPC4 tumor-suppressor pathway in human pancreatic cancer cells.
Author:	Sohn, T A\|Su, G H\|Ryu, B\|Yeo, C J\|Kern, S E
PMID:	11323508

95.
Journal:	Genes Chromosomes Cancer. 2001 Jul;31(3):295-9.
Title:	Exclusion of SMAD4 mutation as an early genetic change in human pancreatic ductal tumorigenesis.
Author:	Inoue, H\|Furukawa, T\|Sunamura, M\|Takeda, K\|Matsuno, S\|Horii, A
PMID:	11391801

96.
Journal:	Int J Oncol. 2001 Jul;19(1):71-81.
Title:	Altered expression of TGFB receptors and mitogenic effects of TGFB in pancreatic carcinomas.
Author:	Jonson, T\|Albrechtsson, E\|Axelson, J\|Heidenblad, M\|Gorunova, L\|Johansson, B\|Hoglund, M
PMID:	11408925

97.
Journal:	Int J Cancer. 2001 Jul 15;93(2):204-11.
Title:	TGF-beta-induced invasiveness of pancreatic cancer cells is mediated by matrix metalloproteinase-2 and the urokinase plasminogen activator system.
Author:	Ellenrieder, V\|Hendler, S F\|Ruhland, C\|Boeck, W\|Adler, G\|Gress, T M
PMID:	11410867

98.
Journal:	Am J Surg Pathol. 2001 Jul;25(7):942-8.
Title:	The immunohistochemical mucin expression pattern distinguishes different types of intraductal papillary mucinous neoplasms of the pancreas and determines their relationship to mucinous noncystic carcinoma and ductal adenocarcinoma.
Author:	Luttges, J\|Zamboni, G\|Longnecker, D\|Kloppel, G
PMID:	11420467

99.
Journal:	Hepatogastroenterology. 2001 Jul-Aug;48(40):933-8.
Title:	Molecular diagnosis of pancreatic cancer.
Author:	Inoue, S\|Tezel, E\|Nakao, A
PMID:	11490843

100.
Journal:	J Biol Chem. 2001 Nov 16;276(46):43175-81. Epub 2001 Sep 11.
Title:	Loss of Smad4 function in pancreatic tumors: C-terminal truncation leads to decreased stability.
Author:	Maurice, D\|Pierreux, C E\|Howell, M\|Wilentz, R E\|Owen, M J\|Hill, C S
PMID:	11553622

101.
Journal:	Cancer J. 2001 Jul-Aug;7(4):251-8.
Title:	Molecular pathology of pancreatic cancer.
Author:	Hruban, R H\|Iacobuzio-Donahue, C\|Wilentz, R E\|Goggins, M\|Kern, S E
PMID:	11561601

102.
Journal:	Am J Pathol. 2001 Nov;159(5):1619-27.
Title:	Distinctive molecular genetic alterations in sporadic and familial adenomatous polyposis-associated pancreatoblastomas : frequent alterations in the APC/beta-catenin pathway and chromosome 11p.
Author:	Abraham, S C\|Wu, T T\|Klimstra, D S\|Finn, L S\|Lee, J H\|Yeo, C J\|Cameron, J L\|Hruban, R H
PMID:	11696422

103.
Journal:	Biochem Biophys Res Commun. 2001 Nov 30;289(2):350-7.
Title:	Systematic analysis of the TGF-beta-Smad signaling pathway in gastrointestinal cancer cells.
Author:	Ijichi, H\|Ikenoue, T\|Kato, N\|Mitsuno, Y\|Togo, G\|Kato, J\|Kanai, F\|Shiratori, Y\|Omata, M
PMID:	11716479

104.
Journal:	Cancer Res. 2001 Dec 15;61(24):8830-7.
Title:	Overexpression of p21(WAF1/CIP1) is an early event in the development of pancreatic intraepithelial neoplasia.
Author:	Biankin, A V\|Kench, J G\|Morey, A L\|Lee, C S\|Biankin, S A\|Head, D R\|Hugh, T B\|Henshall, S M\|Sutherland, R L
PMID:	11751405

105.
Journal:	Clin Cancer Res. 2001 Dec;7(12):3853-6.
Title:	SMAD4/DPC4 and pancreatic cancer survival. Commentary re: M. Tascilar et al., The SMAD4 protein and prognosis of pancreatic ductal adenocarcinoma. Clin. Cancer Res., 7: 4115-4121, 2001.
Author:	Liu, F
PMID:	11751474

106.
Journal:	Clin Cancer Res. 2001 Dec;7(12):4115-21.
Title:	The SMAD4 protein and prognosis of pancreatic ductal adenocarcinoma.
Author:	Tascilar, M\|Skinner, H G\|Rosty, C\|Sohn, T\|Wilentz, R E\|Offerhaus, G J\|Adsay, V\|Abrams, R A\|Cameron, J L\|Kern, S E\|Yeo, C J\|Hruban, R H\|Goggins, M
PMID:	11751510

107.
Journal:	Zhonghua Zhong Liu Za Zhi. 2001 Jul;23(4):293-5.
Title:	[Alterations in DPC4 gene in pancreatic cancers].
Author:	Gu, L\|Chen, J\|Cui, Q
PMID:	11783110

108.
Journal:	Virchows Arch. 2001 Dec;439(6):798-802.
Title:	Genetic profile of 22 pancreatic carcinoma cell lines. Analysis of K-ras, p53, p16 and DPC4/Smad4.
Author:	Moore, P S\|Sipos, B\|Orlandini, S\|Sorio, C\|Real, F X\|Lemoine, N R\|Gress, T\|Bassi, C\|Kloppel, G\|Kalthoff, H\|Ungefroren, H\|Lohr, M\|Scarpa, A
PMID:	11787853

109.
Journal:	Zhonghua Bing Li Xue Za Zhi. 2001 Dec;30(6):439-42.
Title:	[Detection of the expression of Smad4, transforming growth factor beta(1) and beta receptor II proteins in paraffin-embedded human pancreatic cancer tissues].
Author:	Gu, L\|Chen, J\|Liu, T\|Li, L\|Lu, Z\|Luo, Y
PMID:	11866987

110.
Journal:	Pancreatology. 2001;1(4):363-8.
Title:	TGF alpha transgenic mice. A model of pancreatic cancer development.
Author:	Greten, F R\|Wagner, M\|Weber, C K\|Zechner, U\|Adler, G\|Schmid, R M
PMID:	12120215

111.
Journal:	Asian Pac J Cancer Prev. 2001;2(4):271-280.
Title:	An Epidemiological Overview of Environmental and Genetic Risk Factors of Pancreatic Cancer.
Author:	Lin, Yingsong\|Tamakoshi, Akiko\|Kawamura, Takashi\|Inaba, Yutaka\|Kikuchi, Shogo\|Motohashi, Yutaka\|Kurosawa, Michiko\|Ohno, Yoshiyuki
PMID:	12718618

112.
Journal:	Am J Pathol. 2002 Mar;160(3):953-62.
Title:	Genetic and immunohistochemical analysis of pancreatic acinar cell carcinoma: frequent allelic loss on chromosome 11p and alterations in the APC/beta-catenin pathway.
Author:	Abraham, Susan C\|Wu, Tsung-Teh\|Hruban, Ralph H\|Lee, Jae-Hyuk\|Yeo, Charles J\|Conlon, Kevin\|Brennan, Murray\|Cameron, John L\|Klimstra, David S
PMID:	11891193

113.
Journal:	Am J Surg Pathol. 2002 Apr;26(4):466-71.
Title:	The mucin profile of noninvasive and invasive mucinous cystic neoplasms of the pancreas.
Author:	Luttges, J\|Feyerabend, B\|Buchelt, T\|Pacena, M\|Kloppel, G
PMID:	11914624

114.
Journal:	Am J Pathol. 2002 Apr;160(4):1361-9.
Title:	Solid-pseudopapillary tumors of the pancreas are genetically distinct from pancreatic ductal adenocarcinomas and almost always harbor beta-catenin mutations.
Author:	Abraham, Susan C\|Klimstra, David S\|Wilentz, Robb E\|Yeo, Charles J\|Conlon, Kevin\|Brennan, Murray\|Cameron, John L\|Wu, Tsung-Teh\|Hruban, Ralph H
PMID:	11943721

115.
Journal:	Mod Pathol. 2002 Apr;15(4):441-7.
Title:	Direct correlation between proliferative activity and dysplasia in pancreatic intraepithelial neoplasia (PanIN): additional evidence for a recently proposed model of progression.
Author:	Klein, Walter M\|Hruban, Ralph H\|Klein-Szanto, Andres J P\|Wilentz, Robb E
PMID:	11950919

116.
Journal:	World J Surg. 2002 Jul;26(7):854-60.
Title:	Application of molecular biology studies to gene therapy treatment strategies.
Author:	Gustin, Allen\|Pederson, Lee\|Miller, Ryan\|Chan, Carlos\|Vickers, Selwyn M
PMID:	11960211

117.
Journal:	Genes Chromosomes Cancer. 2002 Jun;34(2):234-42.
Title:	Suppression of the tumorigenic phenotype by chromosome 18 transfer into pancreatic cancer cell lines.
Author:	Lefter, Liviu P\|Furukawa, Toru\|Sunamura, Makoto\|Duda, Dan G\|Takeda, Kazunori\|Kotobuki, Noriko\|Oshimura, Mitsuo\|Matsuno, Seiki\|Horii, Akira
PMID:	11979557

118.
Journal:	Gut. 2002 Jun;50(6):861-8.
Title:	Aberrant p16(INK4A) and DPC4/Smad4 expression in intraductal papillary mucinous tumours of the pancreas is associated with invasive ductal adenocarcinoma.
Author:	Biankin, A V\|Biankin, S A\|Kench, J G\|Morey, A L\|Lee, C-S\|Head, D R\|Eckstein, R P\|Hugh, T B\|Henshall, S M\|Sutherland, R L
PMID:	12010891

119.
Journal:	J Hepatobiliary Pancreat Surg. 2002;9(1):1-11.
Title:	Molecular prognostic markers in pancreatic cancer.
Author:	Ghaneh, Paula\|Kawesha, Anthony\|Evans, James D\|Neoptolemos, John P
PMID:	12021893

120.
Journal:	J Hepatobiliary Pancreat Surg. 2002;9(1):32-8.
Title:	Gene therapy for pancreatic cancer based on genetic characterization of the disease.
Author:	Sunamura, Makoto\|Yatsuoka, Toshimasa\|Motoi, Fuyuhiko\|Duda, Dan G\|Kimura, Mitsuhiro\|Abe, Tadayoshi\|Yokoyama, Tadaaki\|Inoue, Hiroko\|Oonuma, Masaru\|Takeda, Kazunori\|Matsuno, Seiki
PMID:	12021895

121.
Journal:	Cell Tissue Res. 2002 May;308(2):205-14. Epub 2002 Apr 11.
Title:	Establishment and characterization of four human pancreatic carcinoma cell lines. Genetic alterations in the TGFBR2 gene but not in the MADH4 gene.
Author:	Ku, Ja-Lok\|Yoon, Kyong-Ah\|Kim, Woo-Ho\|Jang, Young\|Suh, Kyung-Suk\|Kim, Sun-Whe\|Park, Yong-Hyun\|Park, Jae-Gahb
PMID:	12037578

122.
Journal:	Hematol Oncol Clin North Am. 2002 Feb;16(1):17-35, v.
Title:	Molecular pathogenesis of pancreatic cancer.
Author:	Hilgers, Werner\|Rosty, Christophe\|Hahn, Stephan A
PMID:	12063826

123.
Journal:	Gut. 2002 Jul;51(1):56-9.
Title:	Frequent loss of SMAD4/DPC4 protein in colorectal cancers.
Author:	Salovaara, R\|Roth, S\|Loukola, A\|Launonen, V\|Sistonen, P\|Avizienyte, E\|Kristo, P\|Jarvinen, H\|Souchelnytskyi, S\|Sarlomo-Rikala, M\|Aaltonen, L A
PMID:	12077092

124.
Journal:	Best Pract Res Clin Gastroenterol. 2002 Jun;16(3):421-33.
Title:	Genetic basis of pancreatic cancer.
Author:	Schmid, Roland M
PMID:	12079267

125.
Journal:	Nihon Geka Gakkai Zasshi. 2002 Jun;103(6):476-81.
Title:	[Genetics of pancreatic cancer: recent advances in molecular diagnosis].
Author:	Hayashi, Naoko\|Egami, Hiroshi\|Ogawa, Michio
PMID:	12094699

126.
Journal:	Oncogene. 2002 Jul 11;21(30):4696-701.
Title:	Carcinogen-induced pancreatic lesions in the mouse: effect of Smad4 and Apc genotypes.
Author:	Cullingworth, Jan\|Hooper, Martin L\|Harrison, David J\|Mason, John O\|Sirard, Christian\|Patek, Charles E\|Clarke, Alan R
PMID:	12096346

127.
Journal:	Cancer Res. 2002 Jul 1;62(13):3789-93.
Title:	Evaluation of candidate genes MAP2K4, MADH4, ACVR1B, and BRCA2 in familial pancreatic cancer: deleterious BRCA2 mutations in 17%.
Author:	Murphy, Kathleen M\|Brune, Kieran A\|Griffin, Constance\|Sollenberger, Jennifer E\|Petersen, Gloria M\|Bansal, Ravi\|Hruban, Ralph H\|Kern, Scott E
PMID:	12097290

128.
Journal:	Virchows Arch. 2002 Jul;441(1):19-24. Epub 2002 Apr 12.
Title:	Ampulla of vater cancers: T-stage and histological subtype but not Dpc4 expression predict prognosis.
Author:	Beghelli, Stefania\|Orlandini, Simonetta\|Moore, Patrick S\|Talamini, Giorgio\|Capelli, Paola\|Zamboni, Giuseppe\|Falconi, Massimo\|Scarpa, Aldo
PMID:	12111196

129.
Journal:	Pancreatology. 2002;2(1):17-25.
Title:	Frequent deletions of tumor suppressor genes in pure pancreatic juice from patients with tumoral or nontumoral pancreatic diseases.
Author:	Costentin, Lydie\|Pages, Philippe\|Bouisson, Michele\|Berthelemy, Philippe\|Buscail, Louis\|Escourrou, Jean\|Pradayrol, Lucien\|Vaysse, Nicole
PMID:	12120000

130.
Journal:	J Biol Chem. 2002 Sep 27;277(39):36118-28. Epub 2002 Jul 24.
Title:	Smad4/DPC4-dependent regulation of biglycan gene expression by transforming growth factor-beta in pancreatic tumor cells.
Author:	Chen, Wen-Bin\|Lenschow, Wolfgang\|Tiede, Karen\|Fischer, Jens W\|Kalthoff, Holger\|Ungefroren, Hendrik
PMID:	12140283

131.
Journal:	Oncogene. 2002 Aug 22;21(37):5783-90.
Title:	TGFbeta inducible early gene enhances TGFbeta/Smad-dependent transcriptional responses.
Author:	Johnsen, Steven A\|Subramaniam, Malayannan\|Janknecht, Ralf\|Spelsberg, Thomas C
PMID:	12173049

132.
Journal:	Int J Gynecol Pathol. 2002 Oct;21(4):391-400.
Title:	Cytokeratins 7 and 20, Dpc4, and MUC5AC in the distinction of metastatic mucinous carcinomas in the ovary from primary ovarian mucinous tumors: Dpc4 assists in identifying metastatic pancreatic carcinomas.
Author:	Ji, Hongxiu\|Isacson, Christina\|Seidman, Jeffrey D\|Kurman, Robert J\|Ronnett, Brigitte M
PMID:	12352188

133.
Journal:	Biochim Biophys Acta. 2002 Oct 9;1588(1):1-6.
Title:	Induction and expression of betaig-h3 in pancreatic cancer cells.
Author:	Schneider, Dominik\|Kleeff, Jorg\|Berberat, Pascal O\|Zhu, Zhaowen\|Korc, Murray\|Friess, Helmut\|Buchler, Markus W
PMID:	12379307

134.
Journal:	Cancer Res. 2002 Nov 1;62(21):6045-51.
Title:	Restoration of transforming growth factor Beta signaling by functional expression of smad4 induces anoikis.
Author:	Ramachandra, Murali\|Atencio, Isabella\|Rahman, Amena\|Vaillancourt, Mei\|Zou, Aihua\|Avanzini, Jenny\|Wills, Ken\|Bookstein, Robert\|Shabram, Paul
PMID:	12414627

135.
Journal:	Clin Cancer Res. 2002 Nov;8(11):3628-38.
Title:	Suppression of tumorigenesis and induction of p15(ink4b) by Smad4/DPC4 in human pancreatic cancer cells.
Author:	Peng, Bailu\|Fleming, Jason B\|Breslin, Tara\|Grau, Ana M\|Fojioka, Shuichi\|Abbruzzese, James L\|Evans, Douglas B\|Ayers, Dan\|Wathen, Kyle\|Wu, Tianai\|Robertson, Kimberly D\|Chiao, Paul J
PMID:	12429655

136.
Journal:	J Clin Oncol. 2002 Dec 1;20(23):4531-42.
Title:	DPC4/Smad4 expression and outcome in pancreatic ductal adenocarcinoma.
Author:	Biankin, Andrew V\|Morey, Adrienne L\|Lee, C-Soon\|Kench, James G\|Biankin, Sandra A\|Hook, Henry C\|Head, Darren R\|Hugh, Thomas B\|Sutherland, Robert L\|Henshall, Susan M
PMID:	12454109

137.
Journal:	Ai Zheng. 2002 Feb;21(2):132-7.
Title:	[Expression of DPC4/Smad4, p21wafI, and p16 in human pancreatic cancer].
Author:	Gu, Li-jun\|Chen, Jie\|Lu, Zhao-hui\|Li, Li\|Zhou, Wei-xun\|Luo, Yu-feng
PMID:	12479060

138.
Journal:	Ann Pathol. 2002 Oct;22(5):349-55.
Title:	[Molecular pathways of pancreatic carcinogenesis].
Author:	Torrisani, Jerome\|Buscail, Louis
PMID:	12483152

139.
Journal:	Oncology (Williston Park). 2002 Dec;16(12):1615-22, 1631-2; discussion 1632-3,
Title:	Pancreatic cancer: epidemiology, genetics, and approaches to screening.
Author:	Konner, Jason\|O'Reilly, Eileen
PMID:	12520639

140.
Journal:	Int J Gastrointest Cancer. 2002;31(1-3):191-7.
Title:	Minute invasive ductal carcinoma of the residual pancreas after distal pancreatectomy for intraductal papillary-mucinous tumor.
Author:	Moriya, Toshiyuki\|Kimura, Wataru\|Sakurai, Fumiaki\|Semba, Shuho\|Ozawa, Koichiro\|Hirai, Ichiro\|Fuse, Akira
PMID:	12622431

141.
Journal:	Hum Cell. 2002 Sep;15(3):138-50.
Title:	Gene therapy for pancreatic cancer targeting the genomic alterations of tumor suppressor genes using replication-selective oncolytic adenovirus.
Author:	Sunamura, Makoto\|Oonuma, Masaru\|Motoi, Fuyuhiko\|Abe, Hisashi\|Saitoh, Yukoh\|Hoshida, Toru\|Ottomo, Shigeru\|Horii, Akira\|Matsuno, Seiki
PMID:	12703544

142.
Journal:	Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2002 Apr;24(2):165-9.
Title:	[Alterations of DPC4/SMAD4/MADH4 gene detected in paraffin-embedded tissues of human pancreatic carcinomas].
Author:	Gu, Li-jun\|Chen, Jie\|Liu, Tong-hua\|Cui, Quan-cai\|Lu, Zhao-hui\|Li, Li\|Gao, Jie
PMID:	12905795

143.
Journal:	Hepatobiliary Pancreat Dis Int. 2002 Nov;1(4):624-9.
Title:	The relationship between loss expression of DPC4/Smad4 gene and carcinogenesis of pancreatobiliary carcinoma.
Author:	Tang, Zhao-Hui\|Zou, Sheng-Quan\|Hao, You-Hua\|Wang, Bao-Ju\|Yang, Xiang-Ping\|Chen, Qi-Qi\|Qiu, Fa-Zu
PMID:	14607700

144.
Journal:	J Cell Physiol. 2003 Jan;194(1):88-99.
Title:	Rap1 reverses transcriptional repression of TGF-beta type II receptor by a mechanism involving AP-1 in the human pancreatic cancer cell line, UK Pan-1.
Author:	Fralix, Kimberly D\|Zhao, Shujie\|Venkatasubbarao, Kolaparthi\|Freeman, James W
PMID:	12447993

145.
Journal:	Oncol Rep. 2003 Jan-Feb;10(1):21-5.
Title:	Differential roles of alterations of p53, p16, and SMAD4 expression in the progression of intraductal papillary-mucinous tumors of the pancreas.
Author:	Sasaki, Shigeru\|Yamamoto, Hiroyuki\|Kaneto, Hiroyuki\|Ozeki, Itaru\|Adachi, Yasuyo\|Takagi, Hideyasu\|Matsumoto, Takeshi\|Itoh, Hideto\|Nagakawa, Tatsuya\|Miyakawa, Hiroyuki\|Muraoka, Shunji\|Fujinaga, Akira\|Suga, Toshihiro\|Satoh, Masaaki\|Itoh, Fumio\|Endo, Takao\|Im
PMID:	12469138

146.
Journal:	Pancreas. 2003 Jan;26(1):42-8.
Title:	Tumor-suppressing pathways in cystic pancreatic tumors.
Author:	Gerdes, Berthold\|Wild, Anja\|Wittenberg, Judith\|Barth, Peter\|Ramaswamy, Annette\|Kersting, Michael\|Luttges, Jutta\|Kloppel, Gunter\|Bartsch, Detlef K
PMID:	12499916

147.
Journal:	Mol Cancer. 2003 Jan 7;2:7.
Title:	Genetic abnormalities in pancreatic cancer.
Author:	Moore, Patrick S\|Beghelli, Stefania\|Zamboni, Giuseppe\|Scarpa, Aldo
PMID:	12537585

148.
Journal:	Br J Cancer. 2003 Feb 10;88(3):420-3.
Title:	Infrequent mutation of the tumour-suppressor gene Smad4 in early-stage colorectal cancer.
Author:	Mamot, C\|Mild, G\|Reuter, J\|Laffer, U\|Metzger, U\|Terracciano, L\|Boulay, J-L\|Herrmann, R\|Rochlitz, C
PMID:	12569386

149.
Journal:	Mol Cancer. 2003 Jan 22;2:15.
Title:	Genetic alterations in pancreatic carcinoma.
Author:	Schneider, Gunter\|Schmid, Roland M
PMID:	12605716

150.
Journal:	Oncogene. 2003 Mar 6;22(9):1317-23.
Title:	TGF-beta-induced nuclear localization of Smad2 and Smad3 in Smad4 null cancer cell lines.
Author:	Fink, Stephen P\|Mikkola, Debra\|Willson, James K V\|Markowitz, Sanford
PMID:	12618756

151.
Journal:	Genes Chromosomes Cancer. 2003 Apr;36(4):340-52.
Title:	Pancreatic carcinoma cell lines with SMAD4 inactivation show distinct expression responses to TGFB1.
Author:	Jonson, Tord\|Heidenblad, Markus\|Hakansson, Petra\|Gorunova, Ludmila\|Johansson, Bertil\|Fioretos, Thoas\|Hoglund, Mattias
PMID:	12619158

152.
Journal:	Chirurg. 2003 Mar;74(3):165-70.
Title:	[Pancreatic carcinogenesis. Clinical implications].
Author:	Schneider, G\|Lersch, C\|Schmid, R M
PMID:	12647072

153.
Journal:	Virchows Arch. 2003 May;442(5):444-52.
Title:	A comprehensive characterization of pancreatic ductal carcinoma cell lines: towards the establishment of an in vitro research platform.
Author:	Sipos, Bence\|Moser, Simone\|Kalthoff, Holger\|Torok, Virag\|Lohr, Matthias\|Kloppel, Gunter
PMID:	12692724

154.
Journal:	Pancreatology. 2003;3(2):169-78.
Title:	Systematic isolation of genes differentially expressed in normal and cancerous tissue of the pancreas.
Author:	Grutzmann, Robert\|Pilarsky, Christian\|Staub, Eike\|Schmitt, Armin O\|Foerder, Melanie\|Specht, Thomas\|Hinzmann, Bernd\|Dahl, Edgar\|Alldinger, Ingo\|Rosenthal, Andre\|Ockert, Detlef\|Saeger, Hans-Detlev
PMID:	12748427

155.
Journal:	Int J Gastrointest Cancer. 2003;33(1):61-9.
Title:	A clinically relevant model of human pancreatic adenocarcinoma identifies patterns of metastasis associated with alterations of the TGF-beta/Smad4 signaling pathway.
Author:	Holloway, Shane\|Davis, Mishel\|Jaber, Raffat\|Fleming, Jason
PMID:	12909738

156.
Journal:	Pathol Res Pract. 2003;199(6):363-71.
Title:	Laser microdissection of small tissue samples--application to chronic pancreatitis tissues.
Author:	Heinmoller, Ernst\|Bockholt, Anke\|Werther, Meike\|Ziemer, Maria\|Muller, Annegret\|Ghadimi, B Michael\|Ruschoff, Josef
PMID:	12924436

157.
Journal:	Am J Surg. 2003 Sep;186(3):279-86.
Title:	The genetics of pancreatic cancer.
Author:	Cowgill, Sarah M\|Muscarella, Peter
PMID:	12946833

158.
Journal:	Mod Pathol. 2003 Sep;16(9):902-12.
Title:	Multicomponent analysis of the pancreatic adenocarcinoma progression model using a pancreatic intraepithelial neoplasia tissue microarray.
Author:	Maitra, Anirban\|Adsay, N Volkan\|Argani, Pedram\|Iacobuzio-Donahue, Christine\|De Marzo, Angelo\|Cameron, John L\|Yeo, Charles J\|Hruban, Ralph H
PMID:	13679454

159.
Journal:	Int J Gynecol Pathol. 2003 Oct;22(4):347-52.
Title:	Loss of Smad4 protein expression occurs infrequently in endometrial carcinomas.
Author:	Liu, Fu-Shing\|Chen, Jung-Ta\|Hsieh, Yeun-Ting\|Ho, Esther Shih-Chu\|Hung, Man-Jung\|Lu, Chien-Hsing\|Chiou, Li-Ching
PMID:	14501814

160.
Journal:	J Hepatobiliary Pancreat Surg. 2003;10(2):125-36.
Title:	Clinicopathological features of pancreatic intraepithelial neoplasias and their relationship to intraductal papillary-mucinous tumors.
Author:	Takaori, Kyoichi\|Kobashi, Yoichiro\|Matsusue, Satoru\|Matsui, Kosuke\|Yamamoto, Tsuyoshi
PMID:	14505145

161.
Journal:	Clin Cancer Res. 2003 Sep 1;9(10 Pt 1):3598-605.
Title:	Pancreatic carcinoma in carriers of a specific 19 base pair deletion of CDKN2A/p16 (p16-leiden).
Author:	de vos tot Nederveen Cappel, Wouter H\|Offerhaus, G Johan A\|van Puijenbroek, Marjo\|Caspers, Eric\|Gruis, Nelleke A\|De Snoo, Femke A\|Lamers, Cornelis B H W\|Griffioen, Gerrit\|Bergman, Wilma\|Vasen, Hans F A\|Morreau, Hans
PMID:	14506146

162.
Journal:	Oncogene. 2003 Sep 25;22(41):6359-68.
Title:	SEL1L expression in pancreatic adenocarcinoma parallels SMAD4 expression and delays tumor growth in vitro and in vivo.
Author:	Cattaneo, Monica\|Orlandini, Simonetta\|Beghelli, Stefania\|Moore, Patrick S\|Sorio, Claudio\|Bonora, Antonio\|Bassi, Claudio\|Talamini, Giorgio\|Zamboni, Giuseppe\|Orlandi, Rosaria\|Menard, Sylvie\|Bernardi, Luigi Rossi\|Biunno, Ida\|Scarpa, Aldo
PMID:	14508516

163.
Journal:	Clin Cancer Res. 2003 Oct 15;9(13):5044-52.
Title:	Inserting chromosome 18 into pancreatic cancer cells switches them to a dormant metastatic phenotype.
Author:	Lefter, Liviu P\|Sunamura, Makoto\|Furukawa, Toru\|Takeda, Kazunori\|Kotobuki, Noriko\|Oshimura, Mitsuo\|Matsuno, Seiki\|Horii, Akira
PMID:	14581380

164.
Journal:	Am J Surg Pathol. 2003 Dec;27(12):1495-501.
Title:	p16 Inactivation in pancreatic intraepithelial neoplasias (PanINs) arising in patients with chronic pancreatitis.
Author:	Rosty, Christophe\|Geradts, Joseph\|Sato, Norihiro\|Wilentz, Robb E\|Roberts, Helen\|Sohn, Taylor\|Cameron, John L\|Yeo, Charles J\|Hruban, Ralph H\|Goggins, Michael
PMID:	14657708

165.
Journal:	World J Gastroenterol. 2003 Dec;9(12):2764-7.
Title:	Loss of DPC4 expression and its correlation with clinicopathological parameters in pancreatic carcinoma.
Author:	Hua, Zhan\|Zhang, Yuan-Chun\|Hu, Xiao-Ming\|Jia, Zhen-Geng
PMID:	14669329

166.
Journal:	Scand J Gastroenterol Suppl. 2003;(239):94-9.
Title:	Surveillance for familial pancreatic cancer.
Author:	de Vos tot Nederveen Cappel, W H\|Lagendijk, M A C\|Lamers, C B H W\|Morreau, H\|Vasen, H F A
PMID:	14743890

167.
Journal:	World J Gastroenterol. 2004 Jan;10(1):132-5.
Title:	Alteration of somatostatin receptor subtype 2 gene expression in pancreatic tumor angiogenesis.
Author:	Qin, Ren-Yi\|Fang, Ru-Liang\|Gupta, Manoj Kumar\|Liu, Zheng-Ren\|Wang, Da-Yu\|Chang, Qing\|Chen, Yi-Bei
PMID:	14695784

168.
Journal:	Biochem J. 2004 Apr 1;379(Pt 1):209-16.
Title:	Molecular and functional consequences of Smad4 C-terminal missense mutations in colorectal tumour cells.
Author:	De Bosscher, Karolien\|Hill, Caroline S\|Nicolas, Francisco J
PMID:	14715079

169.
Journal:	Oncogene. 2004 Feb 5;23(5):1043-51.
Title:	Smad4-independent regulation of p21/WAF1 by transforming growth factor-beta.
Author:	Ijichi, Hideaki\|Otsuka, Motoyuki\|Tateishi, Keisuke\|Ikenoue, Tsuneo\|Kawakami, Takayuki\|Kanai, Fumihiko\|Arakawa, Yoshihiro\|Seki, Naohiko\|Shimizu, Kiyoshi\|Miyazono, Kohei\|Kawabe, Takao\|Omata, Masao
PMID:	14762439

170.
Journal:	Mol Pharmacol. 2004 Mar;65(3):630-8.
Title:	Blockage of intermediate-conductance Ca2+-activated K+ channels inhibit human pancreatic cancer cell growth in vitro.
Author:	Jager, Heike\|Dreker, Tobias\|Buck, Anita\|Giehl, Klaudia\|Gress, Thomas\|Grissmer, Stephan
PMID:	14978241

171.
Journal:	Clin Cancer Res. 2004 Mar 1;10(5):1597-604.
Title:	Missense mutations of MADH4: characterization of the mutational hot spot and functional consequences in human tumors.
Author:	Iacobuzio-Donahue, Christine A\|Song, Jason\|Parmiagiani, Giovanni\|Yeo, Charles J\|Hruban, Ralph H\|Kern, Scott E
PMID:	15014009

172.
Journal:	Virchows Arch. 2004 May;444(5):447-53.
Title:	Microcystic tubulopapillary carcinoma of the pancreas: a new tumor entity?
Author:	Esposito, Irene\|Bauer, Andrea\|Hoheisel, Jorg D\|Kleeff, Jorg\|Friess, Helmut\|Bergmann, Frank\|Rieker, Ralf J\|Otto, Herwart F\|Kloppel, Gunter\|Penzel, Roland
PMID:	15014986

173.
Journal:	Am J Surg Pathol. 2004 Feb;28(2):233-8.
Title:	Intraductal tubular adenoma, pyloric type, of the pancreas: additional observations on a new type of pancreatic neoplasm.
Author:	Albores-Saavedra, Jorge\|Sheahan, Kieran\|O'Riain, Ciaran\|Shukla, Deepti
PMID:	15043313

174.
Journal:	Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2004 Feb;26(1):79-82.
Title:	[Recent advances in gene change of pancreatic cancer].
Author:	Wang, Yu-yue\|Cui, Quan-cai
PMID:	15052782

175.
Journal:	Pancreas. 2004 Apr;28(3):311-6.
Title:	The role of chromosome 18 abnormalities in the progression of pancreatic adenocarcinoma.
Author:	Sunamura, Makoto\|Lefter, Liviu P\|Duda, Dan G\|Morita, Rina\|Inoue, Hiroko\|Yokoyama, Tadaaki\|Yatsuoka, Toshimasa\|Abe, Tadayoshi\|Egawa, Shinichi\|Furukawa, Toru\|Fukushige, Shinichi\|Oshimura, Mitsuo\|Horii, Akira\|Matsuno, Seiki
PMID:	15084978

176.
Journal:	Biochem Biophys Res Commun. 2004 May 21;318(1):289-96.
Title:	Proteomic analysis of the TGF-beta signaling pathway in pancreatic carcinoma cells using stable RNA interference to silence Smad4 expression.
Author:	Imamura, Takaaki\|Kanai, Fumihiko\|Kawakami, Takayuki\|Amarsanaa, Jazag\|Ijichi, Hideaki\|Hoshida, Yujin\|Tanaka, Yasuo\|Ikenoue, Tsuneo\|Tateishi, Keisuke\|Kawabe, Takao\|Arakawa, Yoshihiro\|Miyagishi, Makoto\|Taira, Kazunari\|Yokosuka, Osamu\|Omata, Masao
PMID:	15110786

177.
Journal:	Am J Surg Pathol. 2004 Jun;28(6):813-20.
Title:	Ductuloinsular tumors of the pancreas: endocrine tumors with entrapped nonneoplastic ductules.
Author:	van Eeden, Susanne\|de Leng, Wendy W J\|Offerhaus, G Johan A\|Morsink, Folkert H\|Weterman, Marian A J\|de Krijger, Ronald R\|Kloppel, Gunter\|Klimstra, David S
PMID:	15166675

178.
Journal:	Oncogene. 2004 Jul 29;23(34):5729-38.
Title:	A role for human MUC4 mucin gene, the ErbB2 ligand, as a target of TGF-beta in pancreatic carcinogenesis.
Author:	Jonckheere, Nicolas\|Perrais, Michael\|Mariette, Christophe\|Batra, Surinder K\|Aubert, Jean-Pierre\|Pigny, Pascal\|Van Seuningen, Isabelle
PMID:	15184872

179.
Journal:	Nihon Rinsho. 2004 Jul;62(7):1241-8.
Title:	[TGF-beta signaling pathway in pancreatic cancer cells].
Author:	Ijichi, Hideaki
PMID:	15283139

180.
Journal:	Cancer Res. 2004 Aug 1;64(15):5200-11.
Title:	Targeting endogenous transforming growth factor beta receptor signaling in SMAD4-deficient human pancreatic carcinoma cells inhibits their invasive phenotype1.
Author:	Subramanian, Gayathri\|Schwarz, Roderich E\|Higgins, Linda\|McEnroe, Glenn\|Chakravarty, Sarvajit\|Dugar, Sundeep\|Reiss, Michael
PMID:	15289325

181.
Journal:	Pancreas. 2004 Oct;29(3):193-203.
Title:	Orthotopic transplantation models of pancreatic adenocarcinoma derived from cell lines and primary tumors and displaying varying metastatic activity.
Author:	Loukopoulos, Panayiotis\|Kanetaka, Kengo\|Takamura, Masaaki\|Shibata, Tatsuhiro\|Sakamoto, Michiie\|Hirohashi, Setsuo
PMID:	15367885

182.
Journal:	J Surg Oncol. 2004 Dec 15;88(4):210-6.
Title:	p53 and DPC4 alterations in the bile of patients with pancreatic carcinoma.
Author:	Pantalone, Desiree\|Pelo, Elisbetta\|Minuti, Barbara\|Giotti, Irene\|Mazza, Ernesto\|Falchini, Massimo\|Neri, Bruno\|Nesi, Gabriella\|Roberta Girardi, Lucia\|Pulli, Raffaele\|Credi, Giovanni\|Torricelli, Francesca
PMID:	15565642

183.
Journal:	Oncogene. 2005 Jan 20;24(4):662-71.
Title:	Smad4 silencing in pancreatic cancer cell lines using stable RNA interference and gene expression profiles induced by transforming growth factor-beta.
Author:	Jazag, Amarsanaa\|Ijichi, Hideaki\|Kanai, Fumihiko\|Imamura, Takaaki\|Guleng, Bayasi\|Ohta, Miki\|Imamura, Jun\|Tanaka, Yasuo\|Tateishi, Keisuke\|Ikenoue, Tsuneo\|Kawakami, Takayuki\|Arakawa, Yoshihiro\|Miyagishi, Makoto\|Taira, Kazunari\|Kawabe, Takao\|Omata, Masao
PMID:	15592526

184.
Journal:	Int J Gynecol Pathol. 2005 Jan;24(1):39-55.
Title:	Immunohistochemistry as a tool in the differential diagnosis of ovarian tumors: an update.
Author:	Baker, Patricia M\|Oliva, Esther
PMID:	15626916

185.
Journal:	Int J Gynecol Pathol. 2005 Jan;24(1):67-72.
Title:	Expression of mesothelin, fascin, and prostate stem cell antigen in primary ovarian mucinous tumors and their utility in differentiating primary ovarian mucinous tumors from metastatic pancreatic mucinous carcinomas in the ovary.
Author:	Cao, Dengfeng\|Ji, Hongxiu\|Ronnett, Brigitte M
PMID:	15626919

186.
Journal:	World J Gastroenterol. 2005 Jan 21;11(3):348-52.
Title:	Effect of deleted pancreatic cancer locus 4 gene transfection on biological behaviors of human colorectal carcinoma cells.
Author:	Xiao, De-Sheng\|Wen, Ji-Fang\|Li, Jing-He\|Hu, Zhong-Liang\|Zheng, Hui\|Fu, Chun-Yan
PMID:	15637742

187.
Journal:	Virchows Arch. 2005 Mar;446(3):239-45.
Title:	Mucinous cystic carcinoma of the pancreas: a unique cell line and xenograft model of a preinvasive lesion.
Author:	Sorio, Claudio\|Capelli, Paola\|Lissandrini, Daniele\|Moore, Patrick S\|Balzarini, Piera\|Falconi, Massimo\|Zamboni, Giuseppe\|Scarpa, Aldo
PMID:	15688169

188.
Journal:	Mod Pathol. 2005 Jun;18(6):752-61.
Title:	Expression of novel markers of pancreatic ductal adenocarcinoma in pancreatic nonductal neoplasms: additional evidence of different genetic pathways.
Author:	Cao, Dengfeng\|Maitra, Anirban\|Saavedra, Jorge-Albores\|Klimstra, David S\|Adsay, N Volkan\|Hruban, Ralph H
PMID:	15696124

189.
Journal:	Ann Diagn Pathol. 2005 Apr;9(2):69-76.
Title:	Intestinal and oncocytic variants of pancreatic intraepithelial neoplasia. A morphological and immunohistochemical study.
Author:	Albores-Saavedra, Jorge\|Wu, Jianhua\|Crook, Terri\|Amirkhan, Robin H\|Jones, Lamar\|Hruban, Ralph H
PMID:	15806512

190.
Journal:	Hepatogastroenterology. 2005 Mar-Apr;52(62):398-403.
Title:	MUC1 overexpression is the most reliable marker of invasive carcinoma in intraductal papillary-mucinous tumor (IPMT).
Author:	Ueda, Michio\|Miura, Yasuhiko\|Kunihiro, Osamu\|Ishikawa, Takashi\|Ichikawa, Yasushi\|Endo, Itaru\|Sekido, Hitoshi\|Togo, Shinji\|Shimada, Hiroshi
PMID:	15816444

191.
Journal:	Mod Pathol. 2005 Aug;18(8):1034-42.
Title:	Distinct progression pathways involving the dysfunction of DUSP6/MKP-3 in pancreatic intraepithelial neoplasia and intraductal papillary-mucinous neoplasms of the pancreas.
Author:	Furukawa, Toru\|Fujisaki, Rumi\|Yoshida, Yoshitaro\|Kanai, Naomi\|Sunamura, Makoto\|Abe, Tadayoshi\|Takeda, Kazunori\|Matsuno, Seiki\|Horii, Akira
PMID:	15832194

192.
Journal:	Cancer Res. 2005 Apr 15;65(8):3218-25.
Title:	High nuclear S100A6 (Calcyclin) is significantly associated with poor survival in pancreatic cancer patients.
Author:	Vimalachandran, Dale\|Greenhalf, William\|Thompson, Christopher\|Luttges, Jutta\|Prime, Wendy\|Campbell, Fiona\|Dodson, Andrew\|Watson, Richard\|Crnogorac-Jurcevic, Tatjana\|Lemoine, Nicholas\|Neoptolemos, John\|Costello, Eithne
PMID:	15833853

193.
Journal:	Cancer Biol Ther. 2005 May;4(5):548-54. Epub 2005 May 12.
Title:	Immortalizing the complexity of cancer metastasis: genetic features of lethal metastatic pancreatic cancer obtained from rapid autopsy.
Author:	Embuscado, Erlinda E\|Laheru, Daniel\|Ricci, Francesca\|Yun, Ki Jung\|de Boom Witzel, Sten\|Seigel, Allison\|Flickinger, Katie\|Hidalgo, Manuel\|Bova, G Steven\|Iacobuzio-Donahue, Christine A
PMID:	15846069

194.
Journal:	Am J Pathol. 2005 May;166(5):1379-92.
Title:	SCF(beta-TrCP1) controls Smad4 protein stability in pancreatic cancer cells.
Author:	Wan, Mei\|Huang, Jin\|Jhala, Nirag C\|Tytler, Ewan M\|Yang, Lei\|Vickers, Selwyn M\|Tang, Yi\|Lu, Chongyuan\|Wang, Ning\|Cao, Xu
PMID:	15855639

195.
Journal:	Int J Gastrointest Cancer. 2005;35(2):111-9.
Title:	Biological similarities and differences between pancreatic intraepithelial neoplasias and intraductal papillary mucinous neoplasms.
Author:	Moriya, Toshiyuki\|Kimura, Wataru\|Semba, Shuho\|Sakurai, Fumiaki\|Hirai, Ichiro\|Ma, Jinfeng\|Fuse, Akira\|Maeda, Kunihiko\|Yamakawa, Mitsunori
PMID:	15879625

196.
Journal:	Genes Chromosomes Cancer. 2005 Sep;44(1):37-51.
Title:	Analysis of genomic DNA alterations and mRNA expression patterns in a panel of human pancreatic cancer cell lines.
Author:	Gysin, Stephan\|Rickert, Paula\|Kastury, Kumar\|McMahon, Martin
PMID:	15929091

197.
Journal:	Cancer Res. 2005 Jun 15;65(12):5045-53.
Title:	In vitro modeling of human pancreatic duct epithelial cell transformation defines gene expression changes induced by K-ras oncogenic activation in pancreatic carcinogenesis.
Author:	Qian, Jiaying\|Niu, Jiangong\|Li, Ming\|Chiao, Paul J\|Tsao, Ming-Sound
PMID:	15958547

198.
Journal:	Mol Cell Biol. 2005 Sep;25(18):8108-25.
Title:	Smad4 dependency defines two classes of transforming growth factor {beta} (TGF-{beta}) target genes and distinguishes TGF-{beta}-induced epithelial-mesenchymal transition from its antiproliferative and migratory responses.
Author:	Levy, Laurence\|Hill, Caroline S
PMID:	16135802

199.
Journal:	J Gastrointest Surg. 2005 Sep-Oct;9(7):903-11.
Title:	Vascular endothelial growth factor and DPC4 predict adjuvant therapy outcomes in resected pancreatic cancer.
Author:	Khorana, Alok A\|Hu, Ying Chuan\|Ryan, Charlotte K\|Komorowski, Richard A\|Hostetter, Galen\|Ahrendt, Steven A
PMID:	16137582

200.
Journal:	Eur J Cancer. 2005 Oct;41(15):2213-36.
Title:	Molecular prognostic markers in pancreatic cancer: a systematic review.
Author:	Garcea, G\|Neal, C P\|Pattenden, C J\|Steward, W P\|Berry, D P
PMID:	16146690

201.
Journal:	Cell Mol Biol (Noisy-le-grand). 2005 Sep 2;51(1):61-76.
Title:	Killer genes in pancreatic cancer therapy.
Author:	Fogar, P\|Greco, E\|Basso, D\|Navaglia, F\|Plebani, M\|Pedrazzoli, S
PMID:	16171565

202.
Journal:	Semin Radiat Oncol. 2005 Oct;15(4):254-64.
Title:	Ductal neoplasia of the pancreas: nosologic, clinicopathologic, and biologic aspects.
Author:	Adsay, Nazmi Volkan\|Basturk, Olca\|Cheng, Jeanette D\|Andea, Aleodor A
PMID:	16183479

203.
Journal:	J Cell Sci. 2005 Oct 15;118(Pt 20):4901-12.
Title:	TGFbeta-induced downregulation of E-cadherin-based cell-cell adhesion depends on PI3-kinase and PTEN.
Author:	Vogelmann, Roger\|Nguyen-Tat, Marc-Daniel\|Giehl, Klaudia\|Adler, Guido\|Wedlich, Doris\|Menke, Andre
PMID:	16219695

204.
Journal:	Zhonghua Bing Li Xue Za Zhi. 2005 Jul;34(7):413-6.
Title:	[Influence of Smad4-independent pathway of transforming growth factor beta1 on the biological activity of pancreatic cancer cells].
Author:	Chen, Ying\|Zhu, Ming-hua\|Yu, Guan-zhen\|Li, Fang-mei\|Liu, Xiao-hong
PMID:	16251046

205.
Journal:	Clin Exp Metastasis. 2005;22(6):461-73.
Title:	Restoration of Smad4 in BxPC3 pancreatic cancer cells attenuates proliferation without altering angiogenesis.
Author:	Yasutome, Michiya\|Gunn, Jason\|Korc, Murray
PMID:	16320109

206.
Journal:	Cancer Sci. 2006 Jan;97(1):1-7.
Title:	Molecular mechanisms of pancreatic carcinogenesis.
Author:	Furukawa, Toru\|Sunamura, Makoto\|Horii, Akira
PMID:	16367914

207.
Journal:	Cancer Genet Cytogenet. 2006 Jan 15;164(2):97-109.
Title:	Distribution of breakpoints on chromosome 18 in breast, colorectal, and pancreatic carcinoma cell lines.
Author:	Alsop, Amber E\|Teschendorff, Andrew E\|Edwards, Paul A W
PMID:	16434311

208.
Journal:	Best Pract Res Clin Gastroenterol. 2006 Apr;20(2):211-26.
Title:	Molecular pathogenesis of pancreatic cancer.
Author:	Maitra, Anirban\|Kern, Scott E\|Hruban, Ralph H
PMID:	16549325

209.
Journal:	Int J Mol Med. 2006 May;17(5):761-7.
Title:	Yes-associated protein (YAP65) in relation to Smad7 expression in human pancreatic ductal adenocarcinoma.
Author:	Guo, Junchao\|Kleeff, Jorg\|Zhao, Yupei\|Li, Junsheng\|Giese, Thomas\|Esposito, Irene\|Buchler, Markus W\|Korc, Murray\|Friess, Helmut
PMID:	16596258

210.
Journal:	Nature. 2006 Jun 22;441(7096):1015-9.
Title:	Smad4 signalling in T cells is required for suppression of gastrointestinal cancer.
Author:	Kim, Byung-Gyu\|Li, Cuiling\|Qiao, Wenhui\|Mamura, Mizuko\|Kasprzak, Barbara\|Anver, Miriam\|Wolfraim, Lawrence\|Hong, Suntaek\|Mushinski, Elizabeth\|Potter, Michael\|Kim, Seong-Jin\|Fu, Xin-Yuan\|Deng, Chuxia\|Letterio, John J
PMID:	16791201

211.
Journal:	Med Sci Monit. 2006 Sep;12(9):RA186-93.
Title:	Molecular pathogenesis of pancreatic adenocarcinoma: potential clinical implications.
Author:	Talar-Wojnarowska, Renata\|Malecka-Panas, Ewa
PMID:	16940943

212.
Journal:	Cancer Res. 2006 Oct 1;66(19):9722-30.
Title:	Identification of an agent selectively targeting DPC4 (deleted in pancreatic cancer locus 4)-deficient pancreatic cancer cells.
Author:	Wang, Hong\|Han, Haiyong\|Von Hoff, Daniel D
PMID:	17018631

213.
Journal:	Praxis (Bern 1994). 2006 Nov 1;95(44):1709-12.
Title:	[Pancreatic cancer].
Author:	Schmid, R M
PMID:	17111879

214.
Journal:	Genes Dev. 2006 Nov 15;20(22):3130-46.
Title:	Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer.
Author:	Bardeesy, Nabeel\|Cheng, Kuang-Hung\|Berger, Justin H\|Chu, Gerald C\|Pahler, Jessica\|Olson, Peter\|Hezel, Aram F\|Horner, James\|Lauwers, Gregory Y\|Hanahan, Douglas\|DePinho, Ronald A
PMID:	17114584

215.
Journal:	Oncogene. 2007 Mar 1;26(10):1417-27. Epub 2006 Sep 4.
Title:	Basement membrane component laminin-5 is a target of the tumor suppressor Smad4.
Author:	Zapatka, M\|Zboralski, D\|Radacz, Y\|Bockmann, M\|Arnold, C\|Schoneck, A\|Hoppe, S\|Tannapfel, A\|Schmiegel, W\|Simon-Assmann, P\|Schwarte-Waldhoff, I
PMID:	16953227

216.
Journal:	J Biochem. 2007 Mar;141(3):345-51. Epub 2007 Feb 14.
Title:	Smad4 is essential for down-regulation of E-cadherin induced by TGF-beta in pancreatic cancer cell line PANC-1.
Author:	Takano, Shinichi\|Kanai, Fumihiko\|Jazag, Amarsanaa\|Ijichi, Hideaki\|Yao, Jian\|Ogawa, Hideoki\|Enomoto, Nobuyuki\|Omata, Masao\|Nakao, Atsuhito
PMID:	17301079

217.
Journal:	Cancer Cell. 2007 Mar;11(3):229-43.
Title:	Kras(G12D) and Smad4/Dpc4 haploinsufficiency cooperate to induce mucinous cystic neoplasms and invasive adenocarcinoma of the pancreas.
Author:	Izeradjene, Kamel\|Combs, Chelsea\|Best, Melissa\|Gopinathan, Aarthi\|Wagner, Amary\|Grady, William M\|Deng, Chu-Xia\|Hruban, Ralph H\|Adsay, N Volkan\|Tuveson, David A\|Hingorani, Sunil R
PMID:	17349581

218.
Journal:	Proteomics. 2007 Jun;7(11):1929-40.
Title:	The expression of S100A8 in pancreatic cancer-associated monocytes is associated with the Smad4 status of pancreatic cancer cells.
Author:	Sheikh, Adnan A\|Vimalachandran, Dale\|Thompson, Christopher C\|Jenkins, Rosalind E\|Nedjadi, Taoufik\|Shekouh, Ali\|Campbell, Fiona\|Dodson, Andrew\|Prime, Wendy\|Crnogorac-Jurcevic, Tatjana\|Lemoine, Nicholas R\|Costello, Eithne
PMID:	17469085

219.
Journal:	J Cell Mol Med. 2007 Mar-Apr;11(2):252-85.
Title:	Pathogenesis of colorectal carcinoma and therapeutic implications: the roles of the ubiquitin-proteasome system and Cox-2.
Author:	Voutsadakis, Ioannis A
PMID:	17488476

220.
Journal:	J Hepatobiliary Pancreat Surg. 2007;14(3):224-32. Epub 2007 May 29.
Title:	Molecular genetics of pancreatic intraepithelial neoplasia.
Author:	Feldmann, Georg\|Beaty, Robert\|Hruban, Ralph H\|Maitra, Anirban
PMID:	17520196

221.
Journal:	Cytojournal. 2007 Jun 22;4:13.
Title:	Immunohistochemical expression of SMAD4, CK19, and CA19-9 in fine needle aspiration samples of pancreatic adenocarcinoma: Utility and potential role.
Author:	Zapata, Mauricio\|Cohen, Cynthia\|Siddiqui, Momin T
PMID:	17587453

222.
Journal:	Carcinogenesis. 2007 Nov;28(11):2321-7. Epub 2007 Jul 17.
Title:	RAS/ERK modulates TGFbeta-regulated PTEN expression in human pancreatic adenocarcinoma cells.
Author:	Chow, Jimmy Y C\|Quach, Khai T\|Cabrera, Betty L\|Cabral, Jennifer A\|Beck, Stayce E\|Carethers, John M
PMID:	17638924

223.
Journal:	World J Gastroenterol. 2007 Jul 21;13(27):3714-20.
Title:	Evaluation of clinical relevance of examining K-ras, p16 and p53 mutations along with allelic losses at 9p and 18q in EUS-guided fine needle aspiration samples of patients with chronic pancreatitis and pancreatic cancer.
Author:	Salek, C\|Benesova, L\|Zavoral, M\|Nosek, V\|Kasperova, L\|Ryska, M\|Strnad, R\|Traboulsi, E\|Minarik, M
PMID:	17659731

224.
Journal:	Curr Mol Med. 2007 Aug;7(5):504-21.
Title:	Molecular pathogenesis of pancreatic cancer: advances and challenges.
Author:	Welsch, Thilo\|Kleeff, Jorg\|Friess, Helmut
PMID:	17691965

225.
Journal:	Int J Oncol. 2007 Oct;31(4):693-703.
Title:	Expression of connective tissue growth factor in pancreatic cancer cell lines.
Author:	Kwon, Sungwon\|Munroe, Xander\|Crawley, Suzanne C\|Lee, Hwa Young\|Spong, Suzanne\|Bradham, Douglass\|Gum, James R Jr\|Sleisenger, Marvin H\|Kim, Young S
PMID:	17786299

226.
Journal:	BMC Cancer. 2007 Nov 12;7:209.
Title:	High-level inducible Smad4-reexpression in the cervical cancer cell line C4-II is associated with a gene expression profile that predicts a preferential role of Smad4 in extracellular matrix composition.
Author:	Klein-Scory, Susanne\|Zapatka, Marc\|Eilert-Micus, Christina\|Hoppe, Sabine\|Schwarz, Elisabeth\|Schmiegel, Wolff\|Hahn, Stephan A\|Schwarte-Waldhoff, Irmgard
PMID:	17997817

227.
Journal:	Cytogenet Genome Res. 2007;118(2-4):148-56.
Title:	Molecular cytogenetic characterization of pancreas cancer cell lines reveals high complexity chromosomal alterations.
Author:	Griffin, C A\|Morsberger, L\|Hawkins, A L\|Haddadin, M\|Patel, A\|Ried, T\|Schrock, E\|Perlman, E J\|Jaffee, E
PMID:	18000365

228.
Journal:	Annu Rev Pathol. 2008;3:157-88.
Title:	Pancreatic cancer.
Author:	Maitra, Anirban\|Hruban, Ralph H
PMID:	18039136

229.
Journal:	Dig Dis Sci. 2008 Sep;53(9):2576-82.
Title:	The PMAIP1 gene on chromosome 18 is a candidate tumor suppressor gene in human pancreatic cancer.
Author:	Ishida, Masaharu\|Sunamura, Makoto\|Furukawa, Toru\|Lefter, Liviu P\|Morita, Rina\|Akada, Masanori\|Egawa, Shinichi\|Unno, Michiaki\|Horii, Akira
PMID:	18231856

230.
Journal:	Am J Physiol Gastrointest Liver Physiol. 2008 Apr;294(4):G899-905.
Title:	TGF-beta mediates PTEN suppression and cell motility through calcium-dependent PKC-alpha activation in pancreatic cancer cells.
Author:	Chow, Jimmy Y C\|Dong, Hui\|Quach, Khai T\|Van Nguyen, Phuoc Nam\|Chen, Kevin\|Carethers, John M
PMID:	18239055

231.
Journal:	J Biol Chem. 2008 Apr 25;283(17):11293-301.
Title:	Smad4-dependent TGF-beta signaling suppresses RON receptor tyrosine kinase-dependent motility and invasion of pancreatic cancer cells.
Author:	Zhao, Shujie\|Ammanamanchi, Sudhakar\|Brattain, Michael\|Cao, Lin\|Thangasamy, Amalraj\|Wang, Jing\|Freeman, James W
PMID:	18310076

232.
Journal:	Carcinogenesis. 2008 May;29(5):1070-6.
Title:	Functional blockade of Smad4 leads to a decrease in beta-catenin levels and signaling activity in human pancreatic carcinoma cells.
Author:	Romero, Diana\|Iglesias, Maite\|Vary, Calvin P H\|Quintanilla, Miguel
PMID:	18310088

233.
Journal:	Cancer Sci. 2008 Jul;99(7):1370-6.
Title:	Role of the WWOX gene, encompassing fragile region FRA16D, in suppression of pancreatic carcinoma cells.
Author:	Nakayama, Shunji\|Semba, Shuho\|Maeda, Naoko\|Aqeilan, Rami I\|Huebner, Kay\|Yokozaki, Hiroshi
PMID:	18460020

234.
Journal:	Cancer Res. 2008 Jun 1;68(11):4221-8.
Title:	Inhibition of STAT3 Tyr705 phosphorylation by Smad4 suppresses transforming growth factor beta-mediated invasion and metastasis in pancreatic cancer cells.
Author:	Zhao, Shujie\|Venkatasubbarao, Kolaparthi\|Lazor, Jillian W\|Sperry, Jane\|Jin, Changqing\|Cao, Lin\|Freeman, James W
PMID:	18519681

235.
Journal:	Bull Cancer. 2008 May;95(5):503-12.
Title:	[New molecular targets in pancreatic cancer].
Author:	Torrisani, Jerome\|Bournet, Barbara\|Cordelier, Pierre\|Buscail, Louis
PMID:	18541514

236.
Journal:	Eur J Gastroenterol Hepatol. 2008 Aug;20(8):713-5.
Title:	Pancreatic cancer: a plea for good and comprehensive morphological studies.
Author:	Algul, Hana\|Schmid, Roland M
PMID:	18617774

237.
Journal:	Cancer Sci. 2008 Sep;99(9):1859-64.
Title:	Establishment and molecular profiling of a novel human pancreatic cancer panel for 5-FU.
Author:	Yanagihara, Kazuyoshi\|Takigahira, Misato\|Tanaka, Hiromi\|Arao, Tokuzo\|Aoyagi, Yasuyuki\|Oda, Tatsuya\|Ochiai, Atsushi\|Nishio, Kazuto
PMID:	18691340

238.
Journal:	Hepatobiliary Pancreat Dis Int. 2008 Aug;7(4):345-56.
Title:	Molecular aspects of carcinogenesis in pancreatic cancer.
Author:	Koliopanos, Alexandros\|Avgerinos, Constantinos\|Paraskeva, Constantina\|Touloumis, Zisis\|Kelgiorgi, Dionisisa\|Dervenis, Christos
PMID:	18693168

239.
Journal:	Int J Clin Exp Pathol. 2008 Apr 10;1(6):510-7.
Title:	Differential expression of multiple genes in association with MADH4/DPC4/SMAD4 inactivation in pancreatic cancer.
Author:	Cao, Dengfeng\|Ashfaq, Raheela\|Goggins, Michael G\|Hruban, Ralph H\|Kern, Scott E\|Iacobuzio-Donahue, Christine A
PMID:	18787631

240.
Journal:	Oncol Rep. 2008 Nov;20(5):1053-9.
Title:	Lentiviral-mediated Smad4 RNAi induced anti-proliferation by p16 up-regulation and apoptosis by caspase 3 down-regulation in hepatoma SMMC-7721 cells.
Author:	Huang, Shu\|Zhang, Faming\|Miao, Lin\|Zhang, Huijie\|Fan, Zhining\|Wang, Xuehao\|Ji, Guozhong
PMID:	18949401

241.
Journal:	World J Gastroenterol. 2008 Oct 28;14(40):6254-60.
Title:	Inhibition of pancreatic carcinoma cell growth in vitro by DPC4 gene transfection.
Author:	Shen, Wei\|Tao, Guo-Qing\|Li, De-Chun\|Zhu, Xing-Guo\|Bai, Xia\|Cai, Bing
PMID:	18985820

242.
Journal:	Gut Liver. 2008 Dec;2(3):137-54.
Title:	Precursor lesions of pancreatic cancer.
Author:	Yonezawa, Suguru\|Higashi, Michiyo\|Yamada, Norishige\|Goto, Masamichi
PMID:	20485640

243.
Journal:	Pancreas. 2009 Mar;38(2):184-96.
Title:	Establishment and characterization of 4 new human pancreatic cancer cell lines: evidences of different tumor phenotypes.
Author:	Chifenti, Barbara\|Morelli, Mariangela\|Zavaglia, Michele\|Coviello, Domenico A\|Guerneri, Silvana\|Santucci, Annalisa\|Paffetti, Alessandro\|Masetti, Massimo\|Locci, Maria Teresa\|Bertacca, Gloria\|Capodanno, Alessandra\|Collecchi, Paola\|Campani, Daniela\|Mosca, Fra
PMID:	19002021

244.
Journal:	Cancer Sci. 2009 Jan;100(1):103-10.
Title:	Expression of the calcium-binding protein S100P is regulated by bone morphogenetic protein in pancreatic duct epithelial cell lines.
Author:	Hamada, Shin\|Satoh, Kennichi\|Hirota, Morihisa\|Fujibuchi, Wataru\|Kanno, Atsushi\|Umino, Jun\|Ito, Hiromichi\|Satoh, Akihiko\|Kikuta, Kazuhiro\|Kume, Kiyoshi\|Masamune, Atsushi\|Shimosegawa, Tooru
PMID:	19018761

245.
Journal:	Hum Mutat. 2009 Feb;30(2):E451-9.
Title:	Mutational profiling of cancer candidate genes in glioblastoma, melanoma and pancreatic carcinoma reveals a snapshot of their genomic landscapes.
Author:	Bleeker, Fonnet E\|Lamba, Simona\|Rodolfo, Monica\|Scarpa, Aldo\|Leenstra, Sieger\|Vandertop, W Peter\|Bardelli, Alberto
PMID:	19058223

246.
Journal:	Mol Cancer Ther. 2009 Jan;8(1):36-44.
Title:	UA62784, a novel inhibitor of centromere protein E kinesin-like protein.
Author:	Henderson, Meredith C\|Shaw, Yeng-Jeng Y\|Wang, Hong\|Han, Haiyong\|Hurley, Laurence H\|Flynn, Gary\|Dorr, Robert T\|Von Hoff, Daniel D
PMID:	19139111

247.
Journal:	Ann Surg Oncol. 2009 Apr;16(4):826-35.
Title:	Low-level expression of Smad7 correlates with lymph node metastasis and poor prognosis in patients with pancreatic cancer.
Author:	Wang, Peng\|Fan, Jie\|Chen, Zhen\|Meng, Zhi-Qiang\|Luo, Jian-Min\|Lin, Jun-Hua\|Zhou, Zhen-Hua\|Chen, Hao\|Wang, Kun\|Xu, Zu-De\|Liu, Lu-Ming
PMID:	19165547

248.
Journal:	Arch Pathol Lab Med. 2009 Mar;133(3):413-22.
Title:	The pathology and genetics of metastatic pancreatic cancer.
Author:	Yachida, Shinichi\|Iacobuzio-Donahue, Christine A
PMID:	19260747

249.
Journal:	Mod Pathol. 2009 May;22(5):651-9.
Title:	Adenosquamous carcinoma of the pancreas harbors KRAS2, DPC4 and TP53 molecular alterations similar to pancreatic ductal adenocarcinoma.
Author:	Brody, Jonathan R\|Costantino, Christina L\|Potoczek, Magdalena\|Cozzitorto, Joseph\|McCue, Peter\|Yeo, Charles J\|Hruban, Ralph H\|Witkiewicz, Agnieszka K
PMID:	19270646

250.
Journal:	J Clin Oncol. 2009 Apr 10;27(11):1806-13.
Title:	DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer.
Author:	Iacobuzio-Donahue, Christine A\|Fu, Baojin\|Yachida, Shinichi\|Luo, Mingde\|Abe, Hisashi\|Henderson, Clark M\|Vilardell, Felip\|Wang, Zheng\|Keller, Jesse W\|Banerjee, Priya\|Herman, Joseph M\|Cameron, John L\|Yeo, Charles J\|Halushka, Marc K\|Eshleman, James R\|Raben,
PMID:	19273710

251.
Journal:	Pancreas. 2009 Jul;38(5):551-7.
Title:	Identification and characterization of a novel anticancer agent with selectivity against deleted in pancreatic cancer locus 4 (DPC4)-deficient pancreatic and colon cancer cells.
Author:	Wang, Hong\|Stephens, Bret\|Von Hoff, Daniel D\|Han, Haiyong
PMID:	19276868

252.
Journal:	Cancer Res. 2009 Apr 15;69(8):3681-8.
Title:	Genetic mutations associated with cigarette smoking in pancreatic cancer.
Author:	Blackford, Amanda\|Parmigiani, Giovanni\|Kensler, Thomas W\|Wolfgang, Christopher\|Jones, Sian\|Zhang, Xiaosong\|Parsons, D Willams\|Lin, Jimmy Cheng-Ho\|Leary, Rebecca J\|Eshleman, James R\|Goggins, Michael\|Jaffee, Elizabeth M\|Iacobuzio-Donahue, Christine A\|Maitra
PMID:	19351817

253.
Journal:	Br J Cancer. 2009 May 5;100(9):1438-43.
Title:	Hypermethylation-mediated reduction of WWOX expression in intraductal papillary mucinous neoplasms of the pancreas.
Author:	Nakayama, S\|Semba, S\|Maeda, N\|Matsushita, M\|Kuroda, Y\|Yokozaki, H
PMID:	19352382

254.
Journal:	Am J Surg Pathol. 2009 Aug;33(8):1164-72.
Title:	Intraductal tubulopapillary neoplasms of the pancreas distinct from pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms.
Author:	Yamaguchi, Hiroshi\|Shimizu, Michio\|Ban, Shinichi\|Koyama, Isamu\|Hatori, Takashi\|Fujita, Izumi\|Yamamoto, Masakazu\|Kawamura, Shunji\|Kobayashi, Makio\|Ishida, Kazuyuki\|Morikawa, Takanori\|Motoi, Fuyuhiko\|Unno, Michiaki\|Kanno, Atsushi\|Satoh, Kennichi\|Shimosegawa
PMID:	19440145

255.
Journal:	Anticancer Res. 2009 May;29(5):1803-10.
Title:	Mutation status of K-ras, p53 and allelic losses at 9p and 18q are not prognostic markers in patients with pancreatic cancer.
Author:	Salek, Cyril\|Minarikova, Petra\|Benesova, Lucie\|Nosek, Vladimir\|Strnad, Robin\|Zavoral, Miroslav\|Minarik, Marek
PMID:	19443408

256.
Journal:	Carcinogenesis. 2009 Sep;30(9):1497-506.
Title:	Dual role of Ski in pancreatic cancer cells: tumor-promoting versus metastasis-suppressive function.
Author:	Wang, Peng\|Chen, Zhen\|Meng, Zhi-Qiang\|Fan, Jie\|Luo, Jian-Min\|Liang, Wang\|Lin, Jun-Hua\|Zhou, Zhen-Hua\|Chen, Hao\|Wang, Kun\|Shen, Ye-Hua\|Xu, Zu-De\|Liu, Lu-Ming
PMID:	19546161

257.
Journal:	Clin Cancer Res. 2009 Jul 15;15(14):4674-9.
Title:	SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer.
Author:	Blackford, Amanda\|Serrano, Oscar K\|Wolfgang, Christopher L\|Parmigiani, Giovanni\|Jones, Sian\|Zhang, Xiaosong\|Parsons, D Williams\|Lin, Jimmy Cheng-Ho\|Leary, Rebecca J\|Eshleman, James R\|Goggins, Michael\|Jaffee, Elizabeth M\|Iacobuzio-Donahue, Christine A\|Mait
PMID:	19584151

258.
Journal:	PLoS Genet. 2009 Jul;5(7):e1000575.
Title:	Inactivation of TIF1gamma cooperates with Kras to induce cystic tumors of the pancreas.
Author:	Vincent, David F\|Yan, Kai-Ping\|Treilleux, Isabelle\|Gay, Fabien\|Arfi, Vanessa\|Kaniewski, Bastien\|Marie, Julien C\|Lepinasse, Florian\|Martel, Sylvie\|Goddard-Leon, Sophie\|Iovanna, Juan L\|Dubus, Pierre\|Garcia, Stephane\|Puisieux, Alain\|Rimokh, Ruth\|Bardeesy, Na
PMID:	19629168

259.
Journal:	Cancer Sci. 2009 Nov;100(11):2133-42.
Title:	Promoter-wide analysis of Smad4 binding sites in human epithelial cells.
Author:	Koinuma, Daizo\|Tsutsumi, Shuichi\|Kamimura, Naoko\|Imamura, Takeshi\|Aburatani, Hiroyuki\|Miyazono, Kohei
PMID:	19686287

260.
Journal:	EMBO J. 2009 Nov 18;28(22):3514-22.
Title:	4E-BP1 is a target of Smad4 essential for TGFbeta-mediated inhibition of cell proliferation.
Author:	Azar, Rania\|Alard, Amandine\|Susini, Christiane\|Bousquet, Corinne\|Pyronnet, Stephane
PMID:	19834456

261.
Journal:	Clin Gastroenterol Hepatol. 2009 Nov;7(11 Suppl):S35-9.
Title:	Molecular pathology of pancreatic cancer: implications for molecular targeting therapy.
Author:	Furukawa, Toru
PMID:	19896096

262.
Journal:	Clin Gastroenterol Hepatol. 2009 Nov;7(11 Suppl):S55-8.
Title:	Differentiating neoplastic from benign lesions of the pancreas: translational techniques.
Author:	Khalid, Asif
PMID:	19896100

263.
Journal:	Mol Med Rep. 2009 Jan-Feb;2(1):13-5.
Title:	Alteration of SMAD4 does not participate in tumorigenesis of adenoid cystic carcinoma of the salivary gland.
Author:	Daa, Tsutomu\|Yada, Naomi\|Kashima, Kenji\|Suzuki, Masashi\|Yokoyama, Shigeo
PMID:	21475783

264.
Journal:	Oncogene. 2010 Feb 4;29(5):674-86.
Title:	Synergistic action of Smad4 and Pten in suppressing pancreatic ductal adenocarcinoma formation in mice.
Author:	Xu, X\|Ehdaie, B\|Ohara, N\|Yoshino, T\|Deng, C-X
PMID:	19901970

265.
Journal:	Am J Physiol Gastrointest Liver Physiol. 2010 Feb;298(2):G275-82.
Title:	TGF-beta downregulates PTEN via activation of NF-kappaB in pancreatic cancer cells.
Author:	Chow, Jimmy Y C\|Ban, Makiko\|Wu, Helen L\|Nguyen, Flang\|Huang, Mei\|Chung, Heekyung\|Dong, Hui\|Carethers, John M
PMID:	19940030

266.
Journal:	Int J Biol Sci. 2010 Jan 1;6(1):1-8.
Title:	Smad4-mediated TGF-beta signaling in tumorigenesis.
Author:	Yang, Guan\|Yang, Xiao
PMID:	20087440

267.
Journal:	Am J Surg Pathol. 2010 Apr;34(4):510-8.
Title:	Pancreatic acinar cell carcinomas with prominent ductal differentiation: Mixed acinar ductal carcinoma and mixed acinar endocrine ductal carcinoma.
Author:	Stelow, Edward B\|Shaco-Levy, Ruthy\|Bao, Fei\|Garcia, Joaquin\|Klimstra, David S
PMID:	20182344

268.
Journal:	Pancreas. 2010 May;39(4):425-35.
Title:	Phenotype and genotype of pancreatic cancer cell lines.
Author:	Deer, Emily L\|Gonzalez-Hernandez, Jessica\|Coursen, Jill D\|Shea, Jill E\|Ngatia, Josephat\|Scaife, Courtney L\|Firpo, Matthew A\|Mulvihill, Sean J
PMID:	20418756

269.
Journal:	Virchows Arch. 2010 Jun;456(6):711-7.
Title:	Extensive biliary intraepithelial neoplasia (BilIN) and multifocal early intrahepatic cholangiocarcinoma in non-biliary cirrhosis.
Author:	Rougemont, Anne-Laure\|Genevay, Muriel\|McKee, Thomas A\|Gremaud, Magali\|Mentha, Gilles\|Rubbia-Brandt, Laura
PMID:	20428886

270.
Journal:	Pancreas. 2010 Oct;39(7):1093-103.
Title:	Genomic instability at both the base pair level and the chromosomal level is detectable in earliest PanIN lesions in tissues of chronic pancreatitis.
Author:	Baumgart, Mario\|Werther, Meike\|Bockholt, Anke\|Scheurer, Maria\|Ruschoff, Josef\|Dietmaier, Wolfgang\|Ghadimi, B Michael\|Heinmoller, Ernst
PMID:	20531246

271.
Journal:	Pancreas. 2010 Jul;39(5):662-8.
Title:	Analogs of vitamin E epitomized by alpha-tocopheryl succinate for pancreatic cancer treatment: in vitro results induce caution for in vivo applications.
Author:	Greco, Eliana\|Basso, Daniela\|Fadi, Elisa\|Padoan, Andrea\|Fogar, Paola\|Zambon, Carlo-Federico\|Navaglia, Filippo\|Bozzato, Dania\|Moz, Stefania\|Pedrazzoli, Sergio\|Plebani, Mario
PMID:	20562578

272.
Journal:	Cancer Biol Ther. 2010 Sep 15;10(6):582-7. Epub 2010 Oct 1.
Title:	Prioritization of driver mutations in pancreatic cancer using cancer-specific high-throughput annotation of somatic mutations (CHASM).
Author:	Carter, Hannah\|Samayoa, Josue\|Hruban, Ralph H\|Karchin, Rachel
PMID:	20581473

273.
Journal:	Carcinogenesis. 2010 Sep;31(9):1541-51.
Title:	Smad4 loss is associated with fewer S100A8-positive monocytes in colorectal tumors and attenuated response to S100A8 in colorectal and pancreatic cancer cells.
Author:	Ang, Chin Wee\|Nedjadi, Taoufik\|Sheikh, Adnan A\|Tweedle, Elizabeth M\|Tonack, Sarah\|Honap, Sailish\|Jenkins, Rosalind E\|Park, B Kevin\|Schwarte-Waldhoff, Irmgard\|Khattak, Ilyas\|Azadeh, Bahram\|Dodson, Andrew\|Kalirai, Helen\|Neoptolemos, John P\|Rooney, Paul S\|Co
PMID:	20622003

274.
Journal:	Anticancer Agents Med Chem. 2010 Dec;10(10):742-6.
Title:	FAK and interacting proteins as therapeutic targets in pancreatic cancer.
Author:	Ucar, Deniz A\|Hochwald, Steven N
PMID:	21235432

275.
Journal:	Cancer Biomark. 2010;9(1-6):421-40.
Title:	Molecular pathology of early pancreatic cancer.
Author:	Remmers, Neeley\|Bailey, Jennifer M\|Mohr, Ashley M\|Hollingsworth, Michael A
PMID:	22112488

276.
Journal:	Cancer Epidemiol. 2011 Jun;35(3):265-71.
Title:	Structural and functional analysis of SMAD4 gene promoter in malignant pancreatic and colorectal tissues: detection of two novel polymorphic nucleotide repeats.
Author:	Nikolic, Aleksandra\|Kojic, Snezana\|Knezevic, Srbislav\|Krivokapic, Zoran\|Ristanovic, Momcilo\|Radojkovic, Dragica
PMID:	21036691

277.
Journal:	FEBS Lett. 2011 Jan 3;585(1):207-13.
Title:	MicroRNA 483-3p suppresses the expression of DPC4/Smad4 in pancreatic cancer.
Author:	Hao, Jun\|Zhang, Shuyu\|Zhou, Yingqi\|Hu, Xiangui\|Shao, Chenghao
PMID:	21112326

278.
Journal:	Front Biosci (Elite Ed). 2011 Jan 1;3:750-6.
Title:	Focal adhesion kinase signaling and function in pancreatic cancer.
Author:	Ucar, Deniz A\|Dang, Long H\|Hochwald, Steven N
PMID:	21196348

279.
Journal:	Oncogene. 2011 May 5;30(18):2123-34.
Title:	Oncogenic Ras/Src cooperativity in pancreatic neoplasia.
Author:	Shields, D J\|Murphy, E A\|Desgrosellier, J S\|Mielgo, A\|Lau, S K M\|Barnes, L A\|Lesperance, J\|Huang, M\|Schmedt, C\|Tarin, D\|Lowy, A M\|Cheresh, D A
PMID:	21242978

280.
Journal:	J Gastrointest Cancer. 2011 Jun;42(2):76-84.
Title:	Pancreatic ductal adenocarcinoma and transcription factors: role of c-Myc.
Author:	Skoudy, Anouchka\|Hernandez-Munoz, Inmaculada\|Navarro, Pilar
PMID:	21279552

281.
Journal:	J Biol Chem. 2011 Mar 25;286(12):10495-504.
Title:	Pancreatic cancer cells respond to type I collagen by inducing snail expression to promote membrane type 1 matrix metalloproteinase-dependent collagen invasion.
Author:	Shields, Mario A\|Dangi-Garimella, Surabhi\|Krantz, Seth B\|Bentrem, David J\|Munshi, Hidayatullah G
PMID:	21288898

282.
Journal:	Biochem Biophys Res Commun. 2011 Mar 25;406(4):552-7.
Title:	MicroRNA 421 suppresses DPC4/Smad4 in pancreatic cancer.
Author:	Hao, Jun\|Zhang, Shuyu\|Zhou, Yingqi\|Liu, Cong\|Hu, Xiangui\|Shao, Chenghao
PMID:	21352803

283.
Journal:	Br J Cancer. 2011 Apr 26;104(9):1440-51.
Title:	Meta-analysis of immunohistochemical prognostic markers in resected pancreatic cancer.
Author:	Smith, R A\|Tang, J\|Tudur-Smith, C\|Neoptolemos, J P\|Ghaneh, P
PMID:	21448172

284.
Journal:	Dig Endosc. 2011 May;23 Suppl 1:43-5.
Title:	Genetic diagnosis of pancreatic cancer using specimens obtained by EUS-FNA.
Author:	Ryozawa, Shomei\|Iwano, Hirotoshi\|Taba, Kumiko\|Sen-yo, Manabu\|Uekitani, Toshiyuki
PMID:	21535200

285.
Journal:	Mod Pathol. 2011 Sep;24(9):1229-36.
Title:	Analysis of LKB1 mutations and other molecular alterations in pancreatic acinar cell carcinoma.
Author:	de Wilde, Roeland F\|Ottenhof, Niki A\|Jansen, Marnix\|Morsink, Folkert H M\|de Leng, Wendy W J\|Offerhaus, G Johan A\|Brosens, Lodewijk A A
PMID:	21572398

286.
Journal:	Cancer Radiother. 2011 Aug;15(5):365-75.
Title:	[New perspectives for radiosensitization in pancreatic carcinoma: a review of mechanisms involved in pancreatic tumorigenesis].
Author:	Huguet, F\|Fernet, M\|Monnier, L\|Touboul, E\|Favaudon, V
PMID:	21664851

287.
Journal:	J Clin Oncol. 2011 Aug 1;29(22):3037-43.
Title:	Phase II trial of cetuximab, gemcitabine, and oxaliplatin followed by chemoradiation with cetuximab for locally advanced (T4) pancreatic adenocarcinoma: correlation of Smad4(Dpc4) immunostaining with pattern of disease progression.
Author:	Crane, Christopher H\|Varadhachary, Gauri R\|Yordy, John S\|Staerkel, Gregg A\|Javle, Milind M\|Safran, Howard\|Haque, Waqar\|Hobbs, Bridgett D\|Krishnan, Sunil\|Fleming, Jason B\|Das, Prajnan\|Lee, Jeffrey E\|Abbruzzese, James L\|Wolff, Robert A
PMID:	21709185

288.
Journal:	J Gastrointest Surg. 2011 Sep;15(9):1611-7.
Title:	Pulmonary resection for isolated pancreatic adenocarcinoma metastasis: an analysis of outcomes and survival.
Author:	Arnaoutakis, George J\|Rangachari, Deepa\|Laheru, Daniel A\|Iacobuzio-Donahue, Chris A\|Hruban, Ralph H\|Herman, Joseph M\|Edil, Barish H\|Pawlik, Timothy M\|Schulick, Richard D\|Cameron, John L\|Meneshian, Avedis\|Yang, Stephen C\|Wolfgang, Christopher L
PMID:	21725701

289.
Journal:	Clin Cancer Res. 2011 Sep 1;17(17):5793-800.
Title:	Tumor engraftment in nude mice and enrichment in stroma- related gene pathways predict poor survival and resistance to gemcitabine in patients with pancreatic cancer.
Author:	Garrido-Laguna, Ignacio\|Uson, Maria\|Rajeshkumar, N V\|Tan, Aik Choon\|de Oliveira, Elizabeth\|Karikari, Collins\|Villaroel, Maria C\|Salomon, Ana\|Taylor, Gretchen\|Sharma, Rajni\|Hruban, Ralph H\|Maitra, Anirban\|Laheru, Daniel\|Rubio-Viqueira, Belen\|Jimeno, Antoni
PMID:	21742805

290.
Journal:	Pancreas. 2011 Aug;40(6):905-10.
Title:	Establishment and characterization of a new cell line, A99, from a primary small cell carcinoma of the pancreas.
Author:	Yachida, Shinichi\|Zhong, Yi\|Patrascu, Raul\|Davis, Meghan B\|Morsberger, Laura A\|Griffin, Constance A\|Hruban, Ralph H\|Laheru, Daniel\|Iacobuzio-Donahue, Christine A
PMID:	21768923

291.
Journal:	Curr Genomics. 2011 Mar;12(1):15-24.
Title:	Genetic and epigenetic alterations in pancreatic carcinogenesis.
Author:	Delpu, Yannick\|Hanoun, Naima\|Lulka, Hubert\|Sicard, Flavie\|Selves, Janick\|Buscail, Louis\|Torrisani, Jerome\|Cordelier, Pierre
PMID:	21886451

292.
Journal:	JOP. 2011 Sep 9;12(5):464-8.
Title:	A minute pancreatic ductal adenocarcinoma with lipomatous pseudohypertrophy of the pancreas.
Author:	Izumi, Sadanobu\|Nakamura, Satoko\|Tokumo, Masaki\|Mano, Shohei
PMID:	21904072

293.
Journal:	Indian J Cancer. 2011 Jul-Sep;48(3):351-60.
Title:	The Smad family and its role in pancreatic cancer.
Author:	Singh, P\|Wig, J D\|Srinivasan, R
PMID:	21921337

294.
Journal:	Am J Surg Pathol. 2011 Dec;35(12):1812-7.
Title:	Somatic mutations in PIK3CA and activation of AKT in intraductal tubulopapillary neoplasms of the pancreas.
Author:	Yamaguchi, Hiroshi\|Kuboki, Yuko\|Hatori, Takashi\|Yamamoto, Masakazu\|Shiratori, Keiko\|Kawamura, Shunji\|Kobayashi, Makio\|Shimizu, Michio\|Ban, Shinichi\|Koyama, Isamu\|Higashi, Morihiro\|Shin, Nobuhiro\|Ishida, Kazuyuki\|Morikawa, Takanori\|Motoi, Fuyuhiko\|Unno, Mi
PMID:	21945955

295.
Journal:	Cell Death Dis. 2011 Dec 1;2:e235.
Title:	Novel tumor suppressive function of Smad4 in serum starvation-induced cell death through PAK1-PUMA pathway.
Author:	Lee, S-H\|Jung, Y-S\|Chung, J-Y\|Oh, A Y\|Lee, S-J\|Choi, D H\|Jang, S M\|Jang, K-S\|Paik, S S\|Ha, N-C\|Park, B-J
PMID:	22130069

296.
Journal:	J Surg Res. 2012 Jan;172(1):29-39.
Title:	Five primary human pancreatic adenocarcinoma cell lines established by the outgrowth method.
Author:	Ruckert, Felix\|Aust, Daniela\|Bohme, Iris\|Werner, Kristin\|Brandt, Aljoscha\|Diamandis, Eleftherios P\|Krautz, Christian\|Hering, Sandra\|Saeger, Hans-Detlev\|Grutzmann, Robert\|Pilarsky, Christian
PMID:	21683373

297.
Journal:	J Gastroenterol. 2012 Feb;47(2):203-13.
Title:	Different subtypes of intraductal papillary mucinous neoplasm in the pancreas have distinct pathways to pancreatic cancer progression.
Author:	Mohri, Dai\|Asaoka, Yoshinari\|Ijichi, Hideaki\|Miyabayashi, Koji\|Kudo, Yotaro\|Seto, Motoko\|Ohta, Miki\|Tada, Motohisa\|Tanaka, Yasuo\|Ikenoue, Tsuneo\|Tateishi, Keisuke\|Isayama, Hiroyuki\|Kanai, Fumihiko\|Fukushima, Noriyoshi\|Tada, Minoru\|Kawabe, Takao\|Omata, Mas
PMID:	22041919

298.
Journal:	J Am Coll Surg. 2012 Jan;214(1):27-32.
Title:	Frequency of subtypes of biliary intraductal papillary mucinous neoplasm and their MUC1, MUC2, and DPC4 expression patterns differ from pancreatic intraductal papillary mucinous neoplasm.
Author:	Sclabas, Guido M\|Barton, Joshua G\|Smyrk, Thomas C\|Barrett, David A\|Khan, Saboor\|Kendrick, Michael L\|Reid-Lombardo, Kaye M\|Donohue, John H\|Nagorney, David M\|Que, Florencia G
PMID:	22112419

299.
Journal:	Curr Mol Med. 2012 Mar;12(3):331-41.
Title:	Genomic sequencing of key genes in mouse pancreatic cancer cells.
Author:	Wang, Y\|Zhang, Y\|Yang, J\|Ni, X\|Liu, S\|Li, Z\|Hodges, S E\|Fisher, W E\|Brunicardi, F C\|Gibbs, R A\|Gingras, M-C\|Li, M
PMID:	22208613

300.
Journal:	Med Oncol. 2012 Dec;29(4):2814-23.
Title:	Aberrant elevated microRNA-146a in dendritic cells (DC) induced by human pancreatic cancer cell line BxPC-3-conditioned medium inhibits DC maturation and activation.
Author:	Du, Jian\|Wang, Jingwen\|Tan, Guang\|Cai, Zhengang\|Zhang, Lu\|Tang, Bo\|Wang, Zhongyu
PMID:	22311263

301.
Journal:	FEBS Lett. 2012 Jul 4;586(14):1984-92.
Title:	Two sides of the story? Smad4 loss in pancreatic cancer versus head-and-neck cancer.
Author:	Malkoski, Stephen P\|Wang, Xiao-Jing
PMID:	22321641

302.
Journal:	Am J Pathol. 2012 Jun;180(6):2214-21.
Title:	Tif1gamma suppresses murine pancreatic tumoral transformation by a Smad4-independent pathway.
Author:	Vincent, David F\|Gout, Johann\|Chuvin, Nicolas\|Arfi, Vanessa\|Pommier, Roxane M\|Bertolino, Philippe\|Jonckheere, Nicolas\|Ripoche, Doriane\|Kaniewski, Bastien\|Martel, Sylvie\|Langlois, Jean-Baptiste\|Goddard-Leon, Sophie\|Colombe, Amelie\|Janier, Marc\|Van Seuninge
PMID:	22469842

303.
Journal:	World J Gastroenterol. 2012 Mar 28;18(12):1286-94.
Title:	Mouse models of pancreatic cancer.
Author:	Herreros-Villanueva, Marta\|Hijona, Elizabeth\|Cosme, Angel\|Bujanda, Luis
PMID:	22493542

304.
Journal:	Autophagy. 2012 Jun;8(6):989-91.
Title:	AGER/RAGE-mediated autophagy promotes pancreatic tumorigenesis and bioenergetics through the IL6-pSTAT3 pathway.
Author:	Kang, Rui\|Tang, Daolin\|Lotze, Michael T\|Zeh, Herbert J 3rd
PMID:	22722139

305.
Journal:	Clin Cancer Res. 2012 Dec 1;18(23):6519-30.
Title:	Genetically defined subsets of human pancreatic cancer show unique in vitro chemosensitivity.
Author:	Cui, Yunfeng\|Brosnan, Jacqueline A\|Blackford, Amanda L\|Sur, Surojit\|Hruban, Ralph H\|Kinzler, Kenneth W\|Vogelstein, Bert\|Maitra, Anirban\|Diaz, Luis A Jr\|Iacobuzio-Donahue, Christine A\|Eshleman, James R
PMID:	22753594

306.
Journal:	Curr Opin Gastroenterol. 2012 Sep;28(5):516-22.
Title:	Emerging frontiers in pancreatic cancer research: elaboration of key genes, cells and the extracellular milieu.
Author:	Kumar-Sinha, Chandan\|Wei, Iris\|Simeone, Diane M
PMID:	22759592

307.
Journal:	Genome Med. 2012 Jul 4;4(7):56.
Title:	Cancer of the ampulla of Vater: analysis of the whole genome sequence exposes a potential therapeutic vulnerability.
Author:	Demeure, Michael J\|Craig, David W\|Sinari, Shripad\|Moses, Tracy M\|Christoforides, Alexis\|Dinh, Jennifer\|Izatt, Tyler\|Aldrich, Jessica\|Decker, Ardis\|Baker, Angela\|Cherni, Irene\|Watanabe, April\|Koep, Lawrence\|Lake, Douglas\|Hostetter, Galen\|Trent, Jeffrey M\|V
PMID:	22762308

308.
Journal:	Cancer Res. 2012 Sep 15;72(18):4840-5.
Title:	TGF-beta and alphavbeta6 integrin act in a common pathway to suppress pancreatic cancer progression.
Author:	Hezel, Aram F\|Deshpande, Vikram\|Zimmerman, Stephanie M\|Contino, Gianmarco\|Alagesan, Brinda\|O'Dell, Michael R\|Rivera, Lee B\|Harper, Jay\|Lonning, Scott\|Brekken, Rolf A\|Bardeesy, Nabeel
PMID:	22787119

309.
Journal:	PLoS One. 2012;7(7):e42234.
Title:	RhoT1 and Smad4 are correlated with lymph node metastasis and overall survival in pancreatic cancer.
Author:	Jiang, Hua\|He, Chengzhi\|Geng, Shasha\|Sheng, Haihui\|Shen, Xiaoying\|Zhang, Xiaoyan\|Li, Hang\|Zhu, Shizhang\|Chen, Ximei\|Yang, Changqing\|Gao, HengJun
PMID:	22860091

310.
Journal:	Mol Cancer Ther. 2012 Oct;11(10):2138-48.
Title:	Cdk4/6 inhibition induces epithelial-mesenchymal transition and enhances invasiveness in pancreatic cancer cells.
Author:	Liu, Fang\|Korc, Murray
PMID:	22869556

311.
Journal:	Chin Med J (Engl). 2012 Jun;125(11):2032-40.
Title:	The effects of genistein on transforming growth factor-beta1-induced invasion and metastasis in human pancreatic cancer cell line Panc-1 in vitro.
Author:	Han, Lei\|Zhang, Hong-Wei\|Zhou, Wen-Ping\|Chen, Guang-Ming\|Guo, Ke-Jian
PMID:	22884073

312.
Journal:	Clin Cancer Res. 2012 Aug 15;18(16):4285-90.
Title:	Conceptual framework for cutting the pancreatic cancer fuel supply.
Author:	Le, Anne\|Rajeshkumar, N V\|Maitra, Anirban\|Dang, Chi V
PMID:	22896695

313.
Journal:	Mol Carcinog. 2012 Oct;51(10):771-82.
Title:	SMAD4-dependent polysome RNA recruitment in human pancreatic cancer cells.
Author:	Thornley, Jessica A\|Trask, Heidi W\|Ringelberg, Carol S\|Ridley, Christian J A\|Wang, Sinny\|Sal-Lari, Richard Cowper\|Moore, Jason H\|Korc, Murray\|Tomlinson, Craig R
PMID:	22965423

314.
Journal:	Clin Cancer Res. 2012 Nov 15;18(22):6339-47.
Title:	Clinical significance of the genetic landscape of pancreatic cancer and implications for identification of potential long-term survivors.
Author:	Yachida, Shinichi\|White, Catherine M\|Naito, Yoshiki\|Zhong, Yi\|Brosnan, Jacqueline A\|Macgregor-Das, Anne M\|Morgan, Richard A\|Saunders, Tyler\|Laheru, Daniel A\|Herman, Joseph M\|Hruban, Ralph H\|Klein, Alison P\|Jones, Sian\|Velculescu, Victor\|Wolfgang, Christop
PMID:	22991414

315.
Journal:	PPAR Res. 2012;2012:367450.
Title:	Peroxisome proliferator-activated receptor gamma and regulations by the ubiquitin-proteasome system in pancreatic cancer.
Author:	Stravodimou, Athina\|Mazzoccoli, Gianluigi\|Voutsadakis, Ioannis A
PMID:	23049538

316.
Journal:	Am J Surg Pathol. 2012 Nov;36(11):1647-55.
Title:	Intraductal tubular neoplasms of the bile ducts.
Author:	Katabi, Nora\|Torres, Javiera\|Klimstra, David S
PMID:	23073323

317.
Journal:	Nature. 2012 Nov 15;491(7424):399-405.
Title:	Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes.
Author:	Biankin, Andrew V\|Waddell, Nicola\|Kassahn, Karin S\|Gingras, Marie-Claude\|Muthuswamy, Lakshmi B\|Johns, Amber L\|Miller, David K\|Wilson, Peter J\|Patch, Ann-Marie\|Wu, Jianmin\|Chang, David K\|Cowley, Mark J\|Gardiner, Brooke B\|Song, Sarah\|Harliwong, Ivon\|Idrisog
PMID:	23103869

318.
Journal:	Korean J Pathol. 2012 Oct;46(5):415-22.
Title:	DPC4 expression in the small intestinal adenocarcinomas.
Author:	Lee, Sun Jae\|Yu, Eunsil\|Bae, Young Kyung\|Jang, Kee-Taek\|Kim, Joon Mee\|Bae, Han-Ik\|Hong, Seung-Mo\|Yoon, Ghil Suk
PMID:	23136567

319.
Journal:	Gastroenterol Res Pract. 2012;2012:243524.
Title:	Molecular Biologic Approach to the Diagnosis of Pancreatic Carcinoma Using Specimens Obtained by EUS-Guided Fine Needle Aspiration.
Author:	Kato, Kiyohito\|Kamada, Hideki\|Fujimori, Takayuki\|Aritomo, Yuuichi\|Ono, Masahiro\|Masaki, Tsutomu
PMID:	23197977

320.
Journal:	Coll Antropol. 2012 Sep;36(3):1063-7.
Title:	Etiology and oncogenesis of pancreatic carcinoma.
Author:	Dobrila-Dintinjana, Renata\|Vanis, Nenad\|Dintinjana, Marijan\|Radic, Mladen
PMID:	23213974

321.
Journal:	Adv Exp Med Biol. 2012;771:229-39.
Title:	Pancreatic cancer and diabetes.
Author:	Morrison, Maureen
PMID:	23393682

322.
Journal:	Antioxid Redox Signal. 2013 Mar 10;18(8):874-87.
Title:	The iron-regulated metastasis suppressor NDRG1 targets NEDD4L, PTEN, and SMAD4 and inhibits the PI3K and Ras signaling pathways.
Author:	Kovacevic, Zaklina\|Chikhani, Sherin\|Lui, Goldie Y L\|Sivagurunathan, Sutharshani\|Richardson, Des R
PMID:	22462691

323.
Journal:	J Hepatobiliary Pancreat Sci. 2013 Mar;20(3):294-302.
Title:	Tumoral epithelial and stromal expression of SMAD proteins in pancreatic ductal adenocarcinomas.
Author:	Handra-Luca, Adriana\|Hammel, Pascal\|Sauvanet, Alain\|Ruszniewski, Philippe\|Couvelard, Anne
PMID:	22581056

324.
Journal:	Oncogene. 2013 Aug 15;32(33):3867-76.
Title:	AGR2 is a SMAD4-suppressible gene that modulates MUC1 levels and promotes the initiation and progression of pancreatic intraepithelial neoplasia.
Author:	Norris, A M\|Gore, A\|Balboni, A\|Young, A\|Longnecker, D S\|Korc, M
PMID:	22945649

325.
Journal:	Oncogene. 2013 Aug 22;32(34):3980-91.
Title:	Deguelin suppresses pancreatic tumor growth and metastasis by inhibiting epithelial-to-mesenchymal transition in an orthotopic model.
Author:	Boreddy, S R\|Srivastava, S K
PMID:	22986522

326.
Journal:	Invest New Drugs. 2013 Jun;31(3):576-86.
Title:	Characterization of a membrane-active anti-tumor agent, UA8967.
Author:	Dorr, Robert T\|Samulitis, Betty K\|Wisner, Lee\|Han, Haiyong\|Zhao, Yu\|Beroza, Paul\|Damodaran, Komath\|Igarashi, Suzu\|Landowski, Terry H\|Von Hoff, Daniel D
PMID:	23179338

327.
Journal:	Pancreas. 2013 Mar;42(2):216-22.
Title:	Genetic alterations of K-ras, p53, c-erbB-2, and DPC4 in pancreatic ductal adenocarcinoma and their correlation with patient survival.
Author:	Shin, Sang Hyun\|Kim, Song Cheol\|Hong, Seung-Mo\|Kim, Young Hoon\|Song, Ki-Byung\|Park, Kwang-Min\|Lee, Young-Joo
PMID:	23344532

328.
Journal:	J Biol Chem. 2013 Mar 22;288(12):8737-49.
Title:	Protein kinase A modulates transforming growth factor-beta signaling through a direct interaction with Smad4 protein.
Author:	Yang, Huibin\|Li, Gangyong\|Wu, Jing-Jiang\|Wang, Lidong\|Uhler, Michael\|Simeone, Diane M
PMID:	23362281

329.
Journal:	Mol Cancer Res. 2013 May;11(5):474-81.
Title:	Suppression of AKT phosphorylation restores rapamycin-based synthetic lethality in SMAD4-defective pancreatic cancer cells.
Author:	Le Gendre, Onica\|Sookdeo, Ayisha\|Duliepre, Stephie-Anne\|Utter, Matthew\|Frias, Maria\|Foster, David A
PMID:	23443316

330.
Journal:	Mol Cancer Res. 2013 Jul;11(7):768-79.
Title:	Stem cell marker nestin is critical for TGF-beta1-mediated tumor progression in pancreatic cancer.
Author:	Su, Huei-Ting\|Weng, Ching-Chieh\|Hsiao, Pi-Jung\|Chen, Li-Hua\|Kuo, Tzu-Lei\|Chen, Yu-Wen\|Kuo, Kung-Kai\|Cheng, Kuang-Hung
PMID:	23552743

331.
Journal:	Am J Pathol. 2013 Jul;183(1):296-303.
Title:	FAM190A deficiency creates a cell division defect.
Author:	Patel, Kalpesh\|Scrimieri, Francesca\|Ghosh, Soma\|Zhong, Jun\|Kim, Min-Sik\|Ren, Yunzhao R\|Morgan, Richard A\|Iacobuzio-Donahue, Christine A\|Pandey, Akhilesh\|Kern, Scott E
PMID:	23665203

332.
Journal:	Cancer Res. 2013 Aug 1;73(15):4781-90.
Title:	PanIN-specific regulation of Wnt signaling by HIF2alpha during early pancreatic tumorigenesis.
Author:	Criscimanna, Angela\|Duan, Li-Juan\|Rhodes, Julie A\|Fendrich, Volker\|Wickline, Emily\|Hartman, Douglas J\|Monga, Satdarshan P S\|Lotze, Michael T\|Gittes, George K\|Fong, Guo-Hua\|Esni, Farzad
PMID:	23749643

333.
Journal:	Cancer Cytopathol. 2013 Dec;121(12):688-94.
Title:	Clinical next-generation sequencing successfully applied to fine-needle aspirations of pulmonary and pancreatic neoplasms.
Author:	Young, Geneva\|Wang, Kai\|He, Jie\|Otto, Geoff\|Hawryluk, Matthew\|Zwirco, Zac\|Brennan, Tina\|Nahas, Michelle\|Donahue, Amy\|Yelensky, Roman\|Lipson, Doron\|Sheehan, Christine E\|Boguniewicz, Ann B\|Stephens, Philip J\|Miller, Vincent A\|Ross, Jeffrey S
PMID:	23893923

334.
Journal:	Br J Cancer. 2013 Oct 1;109(7):1805-12.
Title:	Reduced expression of bone morphogenetic protein receptor IA in pancreatic cancer is associated with a poor prognosis.
Author:	Voorneveld, P W\|Stache, V\|Jacobs, R J\|Smolders, E\|Sitters, A I\|Liesker, A\|Korkmaz, K S\|Lam, S M\|De Miranda, N F C C\|Morreau, H\|Kodach, L L\|Hardwick, J C H
PMID:	23969729

335.
Journal:	Invest New Drugs. 2013 Dec;31(6):1616-25.
Title:	The diaryl oxazole PC-046 is a tubulin-binding agent with experimental anti-tumor efficacy in hematologic cancers.
Author:	Landowski, Terry H\|Samulitis, Betty K\|Dorr, Robert T
PMID:	24037082

336.
Journal:	Pathologe. 2013 Nov;34 Suppl 2:214-20.
Title:	[Will molecular diagnostics become established in pancreatic pathology?].
Author:	Sipos, B\|Sperveslage, J
PMID:	24196616

337.
Journal:	PLoS One. 2013 Oct 18;8(10):e77065.
Title:	Clinical, molecular and genetic validation of a murine orthotopic xenograft model of pancreatic adenocarcinoma using fresh human specimens.
Author:	Walters, Dustin M\|Stokes, Jayme B\|Adair, Sara J\|Stelow, Edward B\|Borgman, Cheryl A\|Lowrey, Bryce T\|Xin, Wenjun\|Blais, Edik M\|Lee, Jae K\|Papin, Jason A\|Parsons, J Thomas\|Bauer, Todd W
PMID:	24204737

338.
Journal:	Med Sci (Paris). 2013 Nov;29(11):991-7.
Title:	[Kras oncogene and pancreatic cancer: thirty years after].
Author:	Bournet, Barbara\|Dufresne, Marlene\|Selves, Janick\|Torrisani, Jerome\|Cordelier, Pierre\|Buscail, Louis
PMID:	24280502

339.
Journal:	Am J Cancer Res. 2014 May 26;4(3):196-210. eCollection 2014.
Title:	Imbalanced expression of Tif1gamma inhibits pancreatic ductal epithelial cell growth.
Author:	Ligr, Martin\|Wu, Xinyu\|Daniels, Garrett\|Zhang, David\|Wang, Huamin\|Hajdu, Cristina\|Wang, Jinhua\|Pan, Ruimin\|Pei, Zhiheng\|Zhang, Lanjing\|Melis, Marcovalerio\|Pincus, Matthew R\|Saunders, John K\|Lee, Peng\|Xu, Ruliang
PMID:	12417044

340.
Journal:	J Pathol. 2014 Mar;232(4):428-35.
Title:	Whole-exome sequencing of pancreatic neoplasms with acinar differentiation.
Author:	Jiao, Yuchen\|Yonescu, Raluca\|Offerhaus, G Johan A\|Klimstra, David S\|Maitra, Anirban\|Eshleman, James R\|Herman, James G\|Poh, Weijie\|Pelosof, Lorraine\|Wolfgang, Christopher L\|Vogelstein, Bert\|Kinzler, Kenneth W\|Hruban, Ralph H\|Papadopoulos, Nickolas\|Wood, La
PMID:	24293293

341.
Journal:	JAMA Surg. 2014 Feb;149(2):145-53.
Title:	Locally advanced pancreatic cancer: association between prolonged preoperative treatment and lymph-node negativity and overall survival.
Author:	Kadera, Brian E\|Sunjaya, Dharma B\|Isacoff, William H\|Li, Luyi\|Hines, O Joe\|Tomlinson, James S\|Dawson, David W\|Rochefort, Matthew M\|Donald, Graham W\|Clerkin, Barbara M\|Reber, Howard A\|Donahue, Timothy R
PMID:	24306217

342.
Journal:	Am J Clin Pathol. 2014 Feb;141(2):168-80.
Title:	Molecular genetics of pancreatic neoplasms and their morphologic correlates: an update on recent advances and potential diagnostic applications.
Author:	Reid, Michelle D\|Saka, Burcu\|Balci, Serdar\|Goldblum, Andrew S\|Adsay, N Volkan
PMID:	24436263

343.
Journal:	Cancer J. 2014 Jan-Feb;20(1):80-4.
Title:	Genetic progression of pancreatic cancer.
Author:	Cowan, Robert W\|Maitra, Anirban
PMID:	24445769

344.
Journal:	Hum Pathol. 2014 Mar;45(3):621-7.
Title:	Pancreatic ductal adenocarcinoma with autoimmune pancreatitis-like histologic and immunohistochemical features.
Author:	Zhang, Xuefeng\|Liu, Xiuli\|Joseph, Loren\|Zhao, Lei\|Hart, John\|Xiao, Shu-Yuan
PMID:	24457081

345.
Journal:	PLoS One. 2014 Jan 20;9(1):e85942.
Title:	Biomarkers of TGF-beta signaling pathway and prognosis of pancreatic cancer.
Author:	Javle, Milind\|Li, Yanan\|Tan, Dongfeng\|Dong, Xiaoqun\|Chang, Ping\|Kar, Siddhartha\|Li, Donghui
PMID:	24465802

346.
Journal:	Pathol Int. 2014 Jan;64(1):10-9.
Title:	Molecular pathology of pancreatic cancer.
Author:	Saiki, Yuriko\|Horii, Akira
PMID:	24471965

347.
Journal:	Int J Toxicol. 2014 Mar-Apr;33(2):116-29.
Title:	Mitochondrial oxidative stress-induced epigenetic modifications in pancreatic epithelial cells.
Author:	Mishra, Pradyumna Kumar\|Raghuram, Gorantla Venkata\|Jain, Deepika\|Jain, Subodh Kumar\|Khare, Naveen Kumar\|Pathak, Neelam
PMID:	24563415

348.
Journal:	J Pathol. 2014 Jul;233(3):217-27.
Title:	Targeted next-generation sequencing of cancer genes dissects the molecular profiles of intraductal papillary neoplasms of the pancreas.
Author:	Amato, Eliana\|Molin, Marco Dal\|Mafficini, Andrea\|Yu, Jun\|Malleo, Giuseppe\|Rusev, Borislav\|Fassan, Matteo\|Antonello, Davide\|Sadakari, Yoshihiko\|Castelli, Paola\|Zamboni, Giuseppe\|Maitra, Anirban\|Salvia, Roberto\|Hruban, Ralph H\|Bassi, Claudio\|Capelli, Paola\|
PMID:	24604757

349.
Journal:	JOP. 2014 Mar 10;15(2):114-7.
Title:	Pharmacogenomics update in pancreatic cancer.
Author:	Puri, Aditi\|Saif, Muhammad Wasif
PMID:	24618431

350.
Journal:	BMC Cancer. 2014 Mar 14;14:181.
Title:	SMAD4 loss triggers the phenotypic changes of pancreatic ductal adenocarcinoma cells.
Author:	Chen, Yu-Wen\|Hsiao, Pi-Jung\|Weng, Ching-Chieh\|Kuo, Kung-Kai\|Kuo, Tzu-Lei\|Wu, Deng-Chyang\|Hung, Wen-Chun\|Cheng, Kuang-Hung
PMID:	24625091

351.
Journal:	J Surg Oncol. 2014 Aug;110(2):171-5.
Title:	Loss of SMAD4 staining in pre-operative cell blocks is associated with distant metastases following pancreaticoduodenectomy with venous resection for pancreatic cancer.
Author:	Boone, Brian A\|Sabbaghian, Shirin\|Zenati, Mazen\|Marsh, J Wallis\|Moser, A James\|Zureikat, Amer H\|Singhi, Aatur D\|Zeh, Herbert J 3rd\|Krasinskas, Alyssa M
PMID:	24665063

352.
Journal:	Cell Commun Signal. 2014 Mar 26;12:20.
Title:	Inflammation and pancreatic cancer: molecular and functional interactions between S100A8, S100A9, NT-S100A8 and TGFbeta1.
Author:	Basso, Daniela\|Bozzato, Dania\|Padoan, Andrea\|Moz, Stefania\|Zambon, Carlo-Federico\|Fogar, Paola\|Greco, Eliana\|Scorzeto, Michele\|Simonato, Francesca\|Navaglia, Filippo\|Fassan, Matteo\|Pelloso, Michela\|Dupont, Sirio\|Pedrazzoli, Sergio\|Fassina, Ambrogio\|Plebani
PMID:	24670043

353.
Journal:	Mol Cancer. 2014 May 27;13:126.
Title:	Homozygous deletion of the activin A receptor, type IB gene is associated with an aggressive cancer phenotype in pancreatic cancer.
Author:	Togashi, Yosuke\|Sakamoto, Hiroki\|Hayashi, Hidetoshi\|Terashima, Masato\|de Velasco, Marco A\|Fujita, Yoshihiko\|Kodera, Yasuo\|Sakai, Kazuko\|Tomida, Shuta\|Kitano, Masayuki\|Ito, Akihiko\|Kudo, Masatoshi\|Nishio, Kazuto
PMID:	24886203

354.
Journal:	Oncol Lett. 2014 Apr;7(4):1165-1168.
Title:	BxPC3 pancreatic cancer cells express a truncated Smad4 protein upon PI3K and mTOR inhibition.
Author:	Legendre, Onica\|Sookdeo, Ayisha\|Foster, David A
PMID:	24944686

355.
Journal:	Am J Cancer Res. 2014 May 26;4(3):196-210. eCollection 2014.
Title:	Imbalanced expression of Tif1gamma inhibits pancreatic ductal epithelial cell growth.
Author:	Ligr, Martin\|Wu, Xinyu\|Daniels, Garrett\|Zhang, David\|Wang, Huamin\|Hajdu, Cristina\|Wang, Jinhua\|Pan, Ruimin\|Pei, Zhiheng\|Zhang, Lanjing\|Melis, Marcovalerio\|Pincus, Matthew R\|Saunders, John K\|Lee, Peng\|Xu, Ruliang
PMID:	24959375

356.
Journal:	Semin Diagn Pathol. 2014 Nov;31(6):491-7.
Title:	Pathology and genetics of pancreatic neoplasms with acinar differentiation.
Author:	Wood, Laura D\|Klimstra, David S
PMID:	25441307

357.
Journal:	Semin Diagn Pathol. 2014 Nov;31(6):484-90.
Title:	Diagnosis and molecular aspects of solid-pseudopapillary neoplasms of the pancreas.
Author:	Terris, Benoit\|Cavard, Catherine
PMID:	25524568

358.
Journal:	Eksp Klin Gastroenterol. 2014;(10):70-6.
Title:	[Genetic aspects of pancreatic cancer].
Author:	Grigor'eva, I N\|Efimova, O V\|Suvorova, T S\|Tov, N L
PMID:	25911935

359.
Journal:	Oncotarget. 2015 Mar 10;6(7):4553-61.
Title:	Molecular landscape of pancreatic cancer: implications for current clinical trials.
Author:	Heestand, Gregory M\|Kurzrock, Razelle
PMID:	11051691

360.
Journal:	Fam Cancer. 2015 Mar;14(1):95-103.
Title:	Familial and sporadic pancreatic cancer share the same molecular pathogenesis.
Author:	Norris, Alexis L\|Roberts, Nicholas J\|Jones, Sian\|Wheelan, Sarah J\|Papadopoulos, Nickolas\|Vogelstein, Bert\|Kinzler, Kenneth W\|Hruban, Ralph H\|Klein, Alison P\|Eshleman, James R
PMID:	25240578

361.
Journal:	Strahlenther Onkol. 2015 Jan;191(1):67-72.
Title:	Radiotherapy for SMAD4-negative musculoskeletal lesions from pancreatic cancer: case report and review.
Author:	Zamboglou, Constantinos\|Bronsert, Peter\|Kusters, Simon\|Salm, Natalie\|Azemar, Marc\|Brunner, Thomas
PMID:	25300625

362.
Journal:	Adv Drug Deliv Rev. 2015 Jan;81:16-33.
Title:	Clinical implications of miRNAs in the pathogenesis, diagnosis and therapy of pancreatic cancer.
Author:	Rachagani, Satyanarayana\|Macha, Muzafar A\|Heimann, Nicholas\|Seshacharyulu, Parthasarathy\|Haridas, Dhanya\|Chugh, Seema\|Batra, Surinder K
PMID:	25453266

363.
Journal:	Tumour Biol. 2015 Jan;36(1):111-9.
Title:	SMAD4 and its role in pancreatic cancer.
Author:	Xia, Xiang\|Wu, Weidong\|Huang, Chen\|Cen, Gang\|Jiang, Tao\|Cao, Jun\|Huang, Kejian\|Qiu, Zhengjun
PMID:	25464861

364.
Journal:	Clin Cancer Res. 2015 Apr 15;21(8):1944-50.
Title:	Very Long-term Survival Following Resection for Pancreatic Cancer Is Not Explained by Commonly Mutated Genes: Results of Whole-Exome Sequencing Analysis.
Author:	Dal Molin, Marco\|Zhang, Ming\|de Wilde, Roeland F\|Ottenhof, Niki A\|Rezaee, Neda\|Wolfgang, Christopher L\|Blackford, Amanda\|Vogelstein, Bert\|Kinzler, Kenneth W\|Papadopoulos, Nickolas\|Hruban, Ralph H\|Maitra, Anirban\|Wood, Laura D
PMID:	25623214

365.
Journal:	Cancer Lett. 2015 May 1;360(2):227-33.
Title:	Metabolic tumor burden is associated with major oncogenomic alterations and serum tumor markers in patients with resected pancreatic cancer.
Author:	Shi, Si\|Ji, Shunrong\|Qin, Yi\|Xu, Jin\|Zhang, Bo\|Xu, Wenyan\|Liu, Jiang\|Long, Jiang\|Liu, Chen\|Liu, Liang\|Ni, Quanxing\|Yu, Xianjun
PMID:	25687883

366.
Journal:	Oncotarget. 2015 Mar 10;6(7):4553-61.
Title:	Molecular landscape of pancreatic cancer: implications for current clinical trials.
Author:	Heestand, Gregory M\|Kurzrock, Razelle
PMID:	25714017

367.
Journal:	Nature. 2015 Feb 26;518(7540):495-501.
Title:	Whole genomes redefine the mutational landscape of pancreatic cancer.
Author:	Waddell, Nicola\|Pajic, Marina\|Patch, Ann-Marie\|Chang, David K\|Kassahn, Karin S\|Bailey, Peter\|Johns, Amber L\|Miller, David\|Nones, Katia\|Quek, Kelly\|Quinn, Michael C J\|Robertson, Alan J\|Fadlullah, Muhammad Z H\|Bruxner, Tim J C\|Christ, Angelika N\|Harliwong,
PMID:	25719666

368.
Journal:	Semin Oncol. 2015 Feb;42(1):177-87.
Title:	Novel targets in pancreatic cancer research.
Author:	Kozak, Geoffrey\|Blanco, Fernando F\|Brody, Jonathan R
PMID:	25726061

369.
Journal:	Exp Mol Pathol. 2015 Apr;98(2):133-5.
Title:	Mononucleotide repeats in the SMAD4 gene promoter in colon carcinoma tissue of Croatian patients.
Author:	Nikolic, Aleksandra\|Cacev, Tamara\|Aralica, Gorana\|Popovic Hadzija, Marijana\|Kapitanovic, Sanja\|Radojkovic, Dragica
PMID:	25742737

370.
Journal:	Pancreas. 2015 May;44(4):660-4.
Title:	SMAD4 expression predicts local spread and treatment failure in resected pancreatic cancer.
Author:	Yamada, Suguru\|Fujii, Tsutomu\|Shimoyama, Yoshie\|Kanda, Mitsuro\|Nakayama, Goro\|Sugimoto, Hiroyuki\|Koike, Masahiko\|Nomoto, Shuji\|Fujiwara, Michitaka\|Nakao, Akimasa\|Kodera, Yasuhiro
PMID:	25760429

371.
Journal:	Am J Pathol. 2015 May;185(5):1457-70.
Title:	Smad4 Decreases the Population of Pancreatic Cancer-Initiating Cells through Transcriptional Repression of ALDH1A1.
Author:	Hoshino, Yukari\|Nishida, Jun\|Katsuno, Yoko\|Koinuma, Daizo\|Aoki, Taku\|Kokudo, Norihiro\|Miyazono, Kohei\|Ehata, Shogo
PMID:	25769430

372.
Journal:	PLoS One. 2015 Mar 24;10(3):e0120851.
Title:	Smad4 loss synergizes with TGFalpha overexpression in promoting pancreatic metaplasia, PanIN development, and fibrosis.
Author:	Garcia-Carracedo, Dario\|Yu, Chih-Chieh\|Akhavan, Nathan\|Fine, Stuart A\|Schonleben, Frank\|Maehara, Naoki\|Karg, Dillon C\|Xie, Chuangao\|Qiu, Wanglong\|Fine, Robert L\|Remotti, Helen E\|Su, Gloria H
PMID:	25803032

373.
Journal:	Cell. 2015 Jun 4;161(6):1345-60.
Title:	RUNX3 Controls a Metastatic Switch in Pancreatic Ductal Adenocarcinoma.
Author:	Whittle, Martin C\|Izeradjene, Kamel\|Rani, P Geetha\|Feng, Libing\|Carlson, Markus A\|DelGiorno, Kathleen E\|Wood, Laura D\|Goggins, Michael\|Hruban, Ralph H\|Chang, Amy E\|Calses, Philamer\|Thorsen, Shelley M\|Hingorani, Sunil R
PMID:	26004068

374.
Journal:	Oncotarget. 2015 Aug 28;6(25):21046-63.
Title:	MicroRNA-301a-3p promotes pancreatic cancer progression via negative regulation of SMAD4.
Author:	Xia, Xiang\|Zhang, Kundong\|Cen, Gang\|Jiang, Tao\|Cao, Jun\|Huang, Kejian\|Huang, Chen\|Zhao, Qian\|Qiu, Zhengjun
PMID:	26019136

375.
Journal:	Genes Chromosomes Cancer. 2015 Aug;54(8):472-481.
Title:	Transflip mutations produce deletions in pancreatic cancer.
Author:	Norris, Alexis L\|Kamiyama, Hirohiko\|Makohon-Moore, Alvin\|Pallavajjala, Aparna\|Morsberger, Laura A\|Lee, Kurt\|Batista, Denise\|Iacobuzio-Donahue, Christine A\|Lin, Ming-Tseh\|Klein, Alison P\|Hruban, Ralph H\|Wheelan, Sarah J\|Eshleman, James R
PMID:	26031834

376.
Journal:	Cell. 2015 Jun 4;161(6):1245-6.
Title:	It's a SMAD/SMAD World.
Author:	Taniguchi, Cullen\|Maitra, Anirban
PMID:	26046433

377.
Journal:	Am J Cancer Res. 2015 Mar 15;5(4):1460-70. eCollection 2015.
Title:	Role of RHOT1 on migration and proliferation of pancreatic cancer.
Author:	Li, Qingqing\|Yao, Lei\|Wei, Youzhen\|Geng, Shasha\|He, Chengzhi\|Jiang, Hua
PMID:	26101710

378.
Journal:	Bull Cancer. 2015 Jun;102(6 Suppl 1):S53-61.
Title:	[Advance in the biology of pancreatic of cancer].
Author:	Buscail, Louis\|Bournet, Barbara\|Dufresne, Marlene\|Torrisani, Jerome\|Cordelier, Pierre
PMID:	26118878

379.
Journal:	Drug Des Devel Ther. 2015 Jul 7;9:3529-45.
Title:	Pancreatic cancer: optimizing treatment options, new, and emerging targeted therapies.
Author:	Chiorean, Elena Gabriela\|Coveler, Andrew L
PMID:	26185420

380.
Journal:	Mol Med Rep. 2015 Oct;12(4):5865-71.
Title:	Emodin inhibits angiogenesis in pancreatic cancer by regulating the transforming growth factor-beta/drosophila mothers against decapentaplegic pathway and angiogenesis-associated microRNAs.
Author:	Lin, Sheng-Zhang\|Xu, Jin-Bo\|Ji, Xu\|Chen, Hui\|Xu, Hong-Tao\|Hu, Ping\|Chen, Liang\|Guo, Jing-Qiang\|Chen, Min-Yuan\|Lu, Dian\|Wang, Zhao-Hong\|Tong, Hong-Fei
PMID:	26238071

381.
Journal:	Gastroenterology. 2015 Nov;149(6):1501-10.
Title:	A combination of molecular markers and clinical features improve the classification of pancreatic cysts.
Author:	Springer, Simeon\|Wang, Yuxuan\|Dal Molin, Marco\|Masica, David L\|Jiao, Yuchen\|Kinde, Isaac\|Blackford, Amanda\|Raman, Siva P\|Wolfgang, Christopher L\|Tomita, Tyler\|Niknafs, Noushin\|Douville, Christopher\|Ptak, Janine\|Dobbyn, Lisa\|Allen, Peter J\|Klimstra, David
PMID:	26253305

382.
Journal:	Mol Endocrinol. 2015 Oct;29(10):1440-53.
Title:	Insights Into SMAD4 Loss in Pancreatic Cancer From Inducible Restoration of TGF-beta Signaling.
Author:	Fullerton, Paul T Jr\|Creighton, Chad J\|Matzuk, Martin M
PMID:	26284758

383.
Journal:	Int J Clin Exp Pathol. 2015 Aug 1;8(8):9279-85. eCollection 2015.
Title:	Reverse correlation of Jab1 and Smad4 in PANC-1 cells involved in the pathogenesis of pancreatic cancer.
Author:	Li, Jun\|Gu, Zhuoyu\|Li, Siyuan\|Xiao, Zhiwei\|Sun, Kan
PMID:	26464677

384.
Journal:	Sci Rep. 2015 Nov 4;5:16067.
Title:	Elevated GRP78 expression is associated with poor prognosis in patients with pancreatic cancer.
Author:	Niu, Zheyu\|Wang, Mengyi\|Zhou, Li\|Yao, Lutian\|Liao, Quan\|Zhao, Yupei
PMID:	26530532

385.
Journal:	PLoS One. 2015 Nov 10;10(11):e0142631.
Title:	Whole Exome Sequencing of Rapid Autopsy Tumors and Xenograft Models Reveals Possible Driver Mutations Underlying Tumor Progression.
Author:	Xie, Tao\|Musteanu, Monica\|Lopez-Casas, Pedro P\|Shields, David J\|Olson, Peter\|Rejto, Paul A\|Hidalgo, Manuel
PMID:	26555578

386.
Journal:	Sci Rep. 2015 Dec 16;5:18425.
Title:	Clinical utility of circulating tumor DNA for molecular assessment in pancreatic cancer.
Author:	Takai, Erina\|Totoki, Yasushi\|Nakamura, Hiromi\|Morizane, Chigusa\|Nara, Satoshi\|Hama, Natsuko\|Suzuki, Masami\|Furukawa, Eisaku\|Kato, Mamoru\|Hayashi, Hideyuki\|Kohno, Takashi\|Ueno, Hideki\|Shimada, Kazuaki\|Okusaka, Takuji\|Nakagama, Hitoshi\|Shibata, Tatsuhiro\|Ya
PMID:	26669280

387.
Journal:	Oncogene. 2016 Feb 4;35(5):577-586.
Title:	Smad4 loss promotes lung cancer formation but increases sensitivity to DNA topoisomerase inhibitors.
Author:	Haeger, Sarah M\|Thompson, Joshua J\|Kalra, Sean\|Cleaver, Timothy G\|Merrick, Daniel\|Wang, Xiao-Jing\|Malkoski, Stephen P
PMID:	25893305

388.
Journal:	Acta Biochim Biophys Sin (Shanghai). 2016 Jan;48(1):27-38.
Title:	RAS signaling and anti-RAS therapy: lessons learned from genetically engineered mouse models, human cancer cells, and patient-related studies.
Author:	Fang, Bingliang
PMID:	26350096

389.
Journal:	Oncotarget. 2016 Jan 5;7(1):323-41.
Title:	Angiogenic gene signature in human pancreatic cancer correlates with TGF-beta and inflammatory transcriptomes.
Author:	Craven, Kelly E\|Gore, Jesse\|Wilson, Julie L\|Korc, Murray
PMID:	26586478

390.
Journal:	Hum Pathol. 2016 Feb;48:117-21.
Title:	Mutational spectrum of intraepithelial neoplasia in pancreatic heterotopia.
Author:	Ma, Changqing\|Gocke, Christopher D\|Hruban, Ralph H\|Belchis, Deborah A
PMID:	26626780

391.
Journal:	Sci Rep. 2016 Jan 12;6:19222.
Title:	Mutant p53 determines pancreatic cancer poor prognosis to pancreatectomy through upregulation of cavin-1 in patients with preoperative serum CA19-9 >/= 1,000 U/mL.
Author:	Xiang, Jin-Feng\|Wang, Wen-Quan\|Liu, Liang\|Xu, Hua-Xiang\|Wu, Chun-Tao\|Yang, Jing-Xuan\|Qi, Zi-Hao\|Wang, Ya-Qi\|Xu, Jin\|Liu, Chen\|Long, Jiang\|Ni, Quan-Xing\|Li, Min\|Yu, Xian-Jun
PMID:	26753987

392.
Journal:	Cancer Biol Ther. 2016;17(3):246-53.
Title:	Nanopore sequencing detects structural variants in cancer.
Author:	Norris, Alexis L\|Workman, Rachael E\|Fan, Yunfan\|Eshleman, James R\|Timp, Winston
PMID:	26787508

393.
Journal:	Lancet. 2016 Jul 2;388(10039):73-85.
Title:	Pancreatic cancer.
Author:	Kamisawa, Terumi\|Wood, Laura D\|Itoi, Takao\|Takaori, Kyoichi
PMID:	26830752

394.
Journal:	Oncotarget. 2016 Mar 8;7(10):11208-22.
Title:	Smad4-dependent suppressor pituitary homeobox 2 promotes PPP2R2A-mediated inhibition of Akt pathway in pancreatic cancer.
Author:	Wang, Qi\|Li, Juanjuan\|Wu, Wei\|Shen, Ruizhe\|Jiang, He\|Qian, Yuting\|Tang, Yanping\|Bai, Tingting\|Wu, Sheng\|Wei, Lumin\|Zang, Yi\|Zhang, Ji\|Wang, Lifu
PMID:	26848620

395.
Journal:	Anticancer Res. 2016 Feb;36(2):517-21.
Title:	Surgical and Oncological Factors Affecting the Successful Engraftment of Patient-derived Xenografts in Pancreatic Ductal Adenocarcinoma.
Author:	Jun, Eunsung\|Jung, Jaeyoon\|Jeong, Seong-Yun\|Choi, Eun Kyung\|Kim, Moon Bo\|Lee, Ji Sun\|Hong, Seung-Mo\|Seol, Hyang Sook\|Hwang, Changmo\|Hoffman, Robert M\|Shim, In Kyong\|Chang, Suhwan\|Kim, Song Cheol
PMID:	26851005

396.
Journal:	Sci Rep. 2016 Feb 17;6:21648.
Title:	MIA PaCa-2 and PANC-1 - pancreas ductal adenocarcinoma cell lines with neuroendocrine differentiation and somatostatin receptors.
Author:	Gradiz, Rui\|Silva, Henriqueta C\|Carvalho, Lina\|Botelho, Maria Filomena\|Mota-Pinto, Anabela
PMID:	26884312

397.
Journal:	Pancreatology. 2016 May-Jun;16(3):372-81.
Title:	Telomerase activity in pancreatic juice differentiates pancreatic cancer from chronic pancreatitis: A meta-analysis.
Author:	Hata, Tatsuo\|Ishida, Masaharu\|Motoi, Fuyuhiko\|Yamaguchi, Takuhiro\|Naitoh, Takeshi\|Katayose, Yu\|Egawa, Shinichi\|Unno, Michiaki
PMID:	26899542

398.
Journal:	Transl Oncol. 2016 Feb;9(1):1-7.
Title:	Prognostic Value of SMAD4 in Pancreatic Cancer: A Meta-Analysis.
Author:	Shugang, Xing\|Hongfa, Yang\|Jianpeng, Liu\|Xu, Zheng\|Jingqi, Feng\|Xiangxiang, Li\|Wei, Li
PMID:	26947875

399.
Journal:	Nat Med. 2016 May;22(5):497-505.
Title:	Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression.
Author:	Laklai, Hanane\|Miroshnikova, Yekaterina A\|Pickup, Michael W\|Collisson, Eric A\|Kim, Grace E\|Barrett, Alex S\|Hill, Ryan C\|Lakins, Johnathon N\|Schlaepfer, David D\|Mouw, Janna K\|LeBleu, Valerie S\|Roy, Nilotpal\|Novitskiy, Sergey V\|Johansen, Julia S\|Poli, Valer
PMID:	27089513

400.
Journal:	Oncol Lett. 2016 May;11(5):3465-3470.
Title:	Smad4 inhibits cell migration via suppression of JNK activity in human pancreatic carcinoma PANC-1 cells.
Author:	Zhang, Xueying\|Cao, Junxia\|Pei, Yujun\|Zhang, Jiyan\|Wang, Qingyang
PMID:	27123137

401.
Journal:	Medicine (Baltimore). 2016 Apr;95(17):e3452.
Title:	Maximum Standard Uptake Value as a Clinical Biomarker for Detecting Loss of SMAD4 Expression and Early Systemic Tumor Recurrence in Resected Left-Sided Pancreatic Cancer.
Author:	Kang, Chang Moo\|Hwang, Ho Kyoung\|Park, Jiae\|Kim, Changsoo\|Cho, Seong-Kyoung\|Yun, Mijin\|Lee, Woo Jung
PMID:	27124039

402.
Journal:	Cancer Discov. 2016 Jun;6(6):572.
Title:	Genotype Adjusts Fibrotic Phenotype to Drive Pancreatic Cancer.
Author:
PMID:	27150537

403.
Journal:	Nat Rev Dis Primers. 2016 Apr 21;2:16022.
Title:	Pancreatic cancer.
Author:	Kleeff, Jorg\|Korc, Murray\|Apte, Minoti\|La Vecchia, Carlo\|Johnson, Colin D\|Biankin, Andrew V\|Neale, Rachel E\|Tempero, Margaret\|Tuveson, David A\|Hruban, Ralph H\|Neoptolemos, John P
PMID:	27158978

404.
Journal:	Br J Surg. 2016 Aug;103(9):1189-99.
Title:	Infiltrating immune cells and gene mutations in pancreatic ductal adenocarcinoma.
Author:	Wang, W-Q\|Liu, L\|Xu, H-X\|Wu, C-T\|Xiang, J-F\|Xu, J\|Liu, C\|Long, J\|Ni, Q-X\|Yu, X-J
PMID:	27256393

405.
Journal:	Am J Surg Pathol. 2016 Sep;40(9):1192-202.
Title:	A Practical Approach to the Classification of WHO Grade 3 (G3) Well-differentiated Neuroendocrine Tumor (WD-NET) and Poorly Differentiated Neuroendocrine Carcinoma (PD-NEC) of the Pancreas.
Author:	Tang, Laura H\|Basturk, Olca\|Sue, Jillian J\|Klimstra, David S
PMID:	27259015

406.
Journal:	Clin J Gastroenterol. 2016 Aug;9(4):261-5.
Title:	Neuroendocrine carcinoma of the pancreas with similar genetic alterations to invasive ductal adenocarcinoma.
Author:	Kimura, Tetsuo\|Miyamoto, Hiroshi\|Fukuya, Akira\|Kitamura, Shinji\|Okamoto, Koichi\|Kimura, Masako\|Muguruma, Naoki\|Ikemoto, Tetsuya\|Shimada, Mitsuo\|Yoneda, Akiko\|Bando, Yoshimi\|Takishita, Makoto\|Takayama, Tetsuji
PMID:	27262570

407.
Journal:	Cancer Lett. 2016 Aug 28;379(1):143-53.
Title:	Combined targeting of TGF-beta, EGFR and HER2 suppresses lymphangiogenesis and metastasis in a pancreatic cancer model.
Author:	Gore, Jesse\|Imasuen-Williams, Imade E\|Conteh, Abass M\|Craven, Kelly E\|Cheng, Monica\|Korc, Murray
PMID:	27267807

408.
Journal:	Nature. 2016 Jun 16;534(7607):407-411.
Title:	Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma.
Author:	Fox, Raymond G\|Lytle, Nikki K\|Jaquish, Dawn V\|Park, Frederick D\|Ito, Takahiro\|Bajaj, Jeevisha\|Koechlein, Claire S\|Zimdahl, Bryan\|Yano, Masato\|Kopp, Janel\|Kritzik, Marcie\|Sicklick, Jason\|Sander, Maike\|Grandgenett, Paul M\|Hollingsworth, Michael A\|Shibata, S
PMID:	27281208

409.
Journal:	Mol Cell Oncol. 2015 Apr 14;3(1):e1025181.
Title:	Point mutations in the tumor suppressor Smad4/DPC4 enhance its phosphorylation by GSK3 and reversibly inactivate TGF-beta signaling.
Author:	Demagny, Hadrien\|De Robertis, Edward M
PMID:	27308538

410.
Journal:	Cell Signal. 2016 Nov;28(11):1652-62.
Title:	Negative control of TRAIL-R1 signaling by transforming growth factor beta1 in pancreatic tumor cells involves Smad-dependent down regulation of TRAIL-R1.
Author:	Radke, David I\|Ungefroren, Hendrik\|Helm, Ole\|Voigt, Susann\|Alp, Gokhan\|Braun, Hendrik\|Hubner, Sebastian\|Dilchert, Janine\|Sebens, Susanne\|Adam, Dieter\|Kalthoff, Holger\|Trauzold, Anna
PMID:	27492861

411.
Journal:	Virchows Arch. 2016 Nov;469(5):523-532.
Title:	Distinct pathways of pathogenesis of intraductal oncocytic papillary neoplasms and intraductal papillary mucinous neoplasms of the pancreas.
Author:	Basturk, Olca\|Chung, Sun M\|Hruban, Ralph H\|Adsay, N Volkan\|Askan, Gokce\|Iacobuzio-Donahue, Christine\|Balci, Serdar\|Zee, Sui Y\|Memis, Bahar\|Shia, Jinru\|Klimstra, David S
PMID:	27591765

412.
Journal:	Oncotarget. 2016 Sep 20;7(38):62533-62546.
Title:	Generation and molecular characterization of pancreatic cancer patient-derived xenografts reveals their heterologous nature.
Author:	Jung, Jaeyun\|Lee, Cue Hyunkyu\|Seol, Hyang Sook\|Choi, Yeon Sook\|Kim, Eunji\|Lee, Eun Ji\|Rhee, Je-Keun\|Singh, Shree Ram\|Jun, Eun Sung\|Han, Buhm\|Hong, Seung Mo\|Kim, Song Cheol\|Chang, Suhwan
PMID:	27613834

413.
Journal:	Nature. 2016 Oct 20;538(7625):378-382.
Title:	A renewed model of pancreatic cancer evolution based on genomic rearrangement patterns.
Author:	Notta, Faiyaz\|Chan-Seng-Yue, Michelle\|Lemire, Mathieu\|Li, Yilong\|Wilson, Gavin W\|Connor, Ashton A\|Denroche, Robert E\|Liang, Sheng-Ben\|Brown, Andrew M K\|Kim, Jaeseung C\|Wang, Tao\|Simpson, Jared T\|Beck, Timothy\|Borgida, Ayelet\|Buchner, Nicholas\|Chadwick, Di
PMID:	27732578

414.
Journal:	Adv Exp Med Biol. 2016;924:13-17.
Title:	Clinical Utility of Circulating Tumor DNA for Molecular Assessment and Precision Medicine in Pancreatic Cancer.
Author:	Takai, Erina\|Totoki, Yasushi\|Nakamura, Hiromi\|Kato, Mamoru\|Shibata, Tatsuhiro\|Yachida, Shinichi
PMID:	27753011

415.
Journal:	Surg Clin North Am. 2016 Dec;96(6):1207-1221.
Title:	Genetics of Pancreatic Cancer and Its Implications on Therapy.
Author:	Tatarian, Talar\|Winter, Jordan M
PMID:	27865273

416.
Journal:	Prog Mol Biol Transl Sci. 2016;144:241-275.
Title:	Molecular Pathogenesis of Pancreatic Cancer.
Author:	Grant, T J\|Hua, K\|Singh, A
PMID:	27865459

417.
Journal:	Gan To Kagaku Ryoho. 2016 Nov;43(11):1326-1331.
Title:	[A Novel Treatment Strategy for Pancreatic Cancer Based on Gene Profiles].
Author:	Hayashi, Hideyuki\|Nishihara, Hiroshi
PMID:	27899773

418.
Journal:	Oncol Lett. 2016 Dec;12(6):4773-4778.
Title:	Impact of chromosome 17q deletion in the primary lesion of colorectal cancer on liver metastasis.
Author:	Kawai, Masaya\|Komiyama, Hiromitsu\|Hosoya, Masaki\|Okubo, Haruna\|Fujii, Tomoaki\|Yokoyama, Norihiko\|Sato, Chiyo\|Ueyama, Takae\|Okuzawa, Atsushi\|Goto, Michitoshi\|Kojima, Yutaka\|Takahashi, Makoto\|Sugimoto, Kiichi\|Ishiyama, Shun\|Munakata, Shinya\|Ogura, Dai\|Niwa,
PMID:	28101224

419.
Journal:	Gut. 2017 Sep;66(9):1677-1687.
Title:	Digital next-generation sequencing identifies low-abundance mutations in pancreatic juice samples collected from the duodenum of patients with pancreatic cancer and intraductal papillary mucinous neoplasms.
Author:	Yu, Jun\|Sadakari, Yoshihiko\|Shindo, Koji\|Suenaga, Masaya\|Brant, Aaron\|Almario, Jose Alejandro Navarro\|Borges, Michael\|Barkley, Thomas\|Fesharakizadeh, Shahriar\|Ford, Madeline\|Hruban, Ralph H\|Shin, Eun Ji\|Lennon, Anne Marie\|Canto, Marcia Irene\|Goggins, Mich
PMID:	27432539

420.
Journal:	Oncogene. 2017 Apr 20;36(16):2202-2214.
Title:	TGFbeta promotes mesenchymal phenotype of pancreatic cancer cells, in part, through epigenetic activation of VAV1.
Author:	Huang, P-H\|Lu, P-J\|Ding, L-Y\|Chu, P-C\|Hsu, W-Y\|Chen, C-S\|Tsao, C-C\|Chen, B-H\|Lee, C-T\|Shan, Y-S\|Chen, C-S
PMID:	27893715

421.
Journal:	Am J Surg Pathol. 2017 Mar;41(3):313-325.
Title:	Intraductal Tubulopapillary Neoplasm of the Pancreas: A Clinicopathologic and Immunohistochemical Analysis of 33 Cases.
Author:	Basturk, Olca\|Adsay, Volkan\|Askan, Gokce\|Dhall, Deepti\|Zamboni, Giuseppe\|Shimizu, Michio\|Cymes, Karina\|Carneiro, Fatima\|Balci, Serdar\|Sigel, Carlie\|Reid, Michelle D\|Esposito, Irene\|Baldaia, Helena\|Allen, Peter\|Kloppel, Gunter\|Klimstra, David S
PMID:	27984235

422.
Journal:	Pancreas. 2017 Mar;46(3):335-340.
Title:	Utility of Assessing the Number of Mutated KRAS, CDKN2A, TP53, and SMAD4 Genes Using a Targeted Deep Sequencing Assay as a Prognostic Biomarker for Pancreatic Cancer.
Author:	Hayashi, Hideyuki\|Kohno, Takashi\|Ueno, Hideki\|Hiraoka, Nobuyoshi\|Kondo, Shunsuke\|Saito, Motonobu\|Shimada, Yoko\|Ichikawa, Hitoshi\|Kato, Mamoru\|Shibata, Tatsuhiro\|Morizane, Chigusa\|Sakamoto, Yasunari\|Shimada, Kazuaki\|Komatsu, Yoshito\|Sakamoto, Naoya\|Okusaka
PMID:	28099251

423.
Journal:	Nature. 2017 Feb 2;542(7639):119-123.
Title:	Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer.
Author:	Dey, Prasenjit\|Baddour, Joelle\|Muller, Florian\|Wu, Chia Chin\|Wang, Huamin\|Liao, Wen-Ting\|Lan, Zangdao\|Chen, Alina\|Gutschner, Tony\|Kang, Yaan\|Fleming, Jason\|Satani, Nikunj\|Zhao, Di\|Achreja, Abhinav\|Yang, Lifeng\|Lee, Jiyoon\|Chang, Edward\|Genovese, Giannicol
PMID:	28099419

424.
Journal:	Cancer Discov. 2017 Apr;7(4):342-343.
Title:	Collateral Lethality in Pancreatic Cancer.
Author:
PMID:	28174172

425.
Journal:	Dig Endosc. 2017 Sep;29(6):657-666.
Title:	Team work and cytopathology molecular diagnosis of solid pancreatic lesions.
Author:	Fabbri, Carlo\|Gibiino, Giulia\|Fornelli, Adele\|Cennamo, Vincenzo\|Grifoni, Daniela\|Visani, Michela\|Acquaviva, Giorgia\|Fassan, Matteo\|Fiorino, Sirio\|Giovanelli, Silvia\|Bassi, Marco\|Ghersi, Stefania\|Tallini, Giovanni\|Jovine, Elio\|Gasbarrini, Antonio\|de Biase,
PMID:	28190274

426.
Journal:	Nat Commun. 2017 Mar 8;8:14686.
Title:	Reconstituting development of pancreatic intraepithelial neoplasia from primary human pancreas duct cells.
Author:	Lee, Jonghyeob\|Snyder, Emily R\|Liu, Yinghua\|Gu, Xueying\|Wang, Jing\|Flowers, Brittany M\|Kim, Yoo Jung\|Park, Sangbin\|Szot, Gregory L\|Hruban, Ralph H\|Longacre, Teri A\|Kim, Seung K
PMID:	28272465

427.
Journal:	J Gastrointest Oncol. 2017 Feb;8(1):164-172.
Title:	Potential actionable targets in appendiceal cancer detected by immunohistochemistry, fluorescent in situ hybridization, and mutational analysis.
Author:	Borazanci, Erkut\|Millis, Sherri Z\|Kimbrough, Jeffery\|Doll, Nancy\|Von Hoff, Daniel\|Ramanathan, Ramesh K
PMID:	28280620

428.
Journal:	BMC Cancer. 2017 Mar 29;17(1):229.
Title:	Protocol of the PANCALYZE trial: a multicenter, prospective study investigating the tumor biomarkers CXCR4, SMAD4, SOX9 and IFIT3 in patients with resected pancreatic adenocarcinoma to predict the pattern of recurrence of the disease.
Author:	Popp, Felix C\|Popp, Marie Christine\|Zhao, Yue\|Betzler, Christopher\|Kropf, Siegfried\|Garlipp, Benjamin\|Benckert, Christoph\|Kalinski, Thomas\|Lippert, Hans\|Bruns, Christiane J
PMID:	28356064

429.
Journal:	Clin Cancer Res. 2017 Apr 1;23(7):1629-1637.
Title:	Pancreatic Cancer: "A Riddle Wrapped in a Mystery inside an Enigma".
Author:	Borazanci, Erkut\|Dang, Chi V\|Robey, Robert W\|Bates, Susan E\|Chabot, John A\|Von Hoff, Daniel D
PMID:	28373361

430.
Journal:	Oncotarget. 2017 Apr 25;8(17):28990-29012.
Title:	Genome-wide DNA methylation analysis reveals molecular subtypes of pancreatic cancer.
Author:	Mishra, Nitish Kumar\|Guda, Chittibabu
PMID:	28423671

431.
Journal:	Cancer Cell Int. 2017 Apr 20;17:47.
Title:	Establishment and characterization of 6 novel patient-derived primary pancreatic ductal adenocarcinoma cell lines from Korean pancreatic cancer patients.
Author:	Kim, Mi-Ju\|Kim, Min-Sun\|Kim, Sung Joo\|An, Soyeon\|Park, Jin\|Park, Hosub\|Lee, Jae Hoon\|Song, Ki-Byung\|Hwang, Dae Wook\|Chang, Suhwan\|Kim, Kyu-Pyo\|Jeong, Seong-Yun\|Kim, Song Cheol\|Hong, Seung-Mo
PMID:	28435405

432.
Journal:	Cancers (Basel). 2017 Apr 28;9(5). pii: cancers9050042.
Title:	KRAS, TP53, CDKN2A, SMAD4, BRCA1, and BRCA2 Mutations in Pancreatic Cancer.
Author:	Cicenas, Jonas\|Kvederaviciute, Kotryna\|Meskinyte, Ingrida\|Meskinyte-Kausiliene, Edita\|Skeberdyte, Aiste\|Cicenas, Jonas
PMID:	28452926

433.
Journal:	PLoS One. 2017 May 5;12(5):e0176844.
Title:	LSL-KrasG12D; LSL-Trp53R172H/+; Ink4flox/+; Ptf1/p48-Cre mice are an applicable model for locally invasive and metastatic pancreatic cancer.
Author:	Ma, Lixiang\|Saiyin, Hexige
PMID:	28475592

434.
Journal:	Int J Mol Sci. 2017 May 19;18(5). pii: ijms18051094.
Title:	The Impact of SMAD4 Loss on Outcome in Patients with Advanced Pancreatic Cancer Treated with Systemic Chemotherapy.
Author:	Ormanns, Steffen\|Haas, Michael\|Remold, Anna\|Kruger, Stephan\|Holdenrieder, Stefan\|Kirchner, Thomas\|Heinemann, Volker\|Boeck, Stefan
PMID:	28534865

435.
Journal:	Clin Cancer Res. 2017 Sep 15;23(18):5639-5647.
Title:	Treatment of Pancreatic Cancer Patient-Derived Xenograft Panel with Metabolic Inhibitors Reveals Efficacy of Phenformin.
Author:	Rajeshkumar, N V\|Yabuuchi, Shinichi\|Pai, Shweta G\|De Oliveira, Elizabeth\|Kamphorst, Jurre J\|Rabinowitz, Joshua D\|Tejero, Hector\|Al-Shahrour, Fatima\|Hidalgo, Manuel\|Maitra, Anirban\|Dang, Chi V
PMID:	28611197

436.
Journal:	Br J Cancer. 2017 Aug 8;117(4):572-582.
Title:	Clinical study of genomic drivers in pancreatic ductal adenocarcinoma.
Author:	Barrett, Michael T\|Deiotte, Ray\|Lenkiewicz, Elizabeth\|Malasi, Smriti\|Holley, Tara\|Evers, Lisa\|Posner, Richard G\|Jones, Timothy\|Han, Haiyong\|Sausen, Mark\|Velculescu, Victor E\|Drebin, Jeffrey\|O'Dwyer, Peter\|Jameson, Gayle\|Ramanathan, Ramesh K\|Von Hoff, Dani
PMID:	28720843

437.
Journal:	J Assoc Genet Technol. 2017;43(3):113-127.
Title:	Elucidation of Novel Chromosomal Abnormalities in Pancreatic Cancer: Conventional and Molecular Cytogenetic Characterization of 16 Pancreatic Cell Lines.
Author:	Shabsovich, David\|Tirado, Carlos A
PMID:	28809762

438.
Journal:	Biomedicines. 2017 Nov 18;5(4). pii: biomedicines5040065.
Title:	Pancreatic Cancer: Molecular Characterization, Clonal Evolution and Cancer Stem Cells.
Author:	Pelosi, Elvira\|Castelli, Germana\|Testa, Ugo
PMID:	29156578

439.
Journal:	Sci Rep. 2017 Dec 11;7(1):17313.
Title:	Negative regulation of TGF-beta1-induced MKK6-p38 and MEK-ERK signalling and epithelial-mesenchymal transition by Rac1b.
Author:	Witte, David\|Otterbein, Hannah\|Forster, Maria\|Giehl, Klaudia\|Zeiser, Robert\|Lehnert, Hendrik\|Ungefroren, Hendrik
PMID:	29229918

440.
Journal:	World J Gastroenterol. 2017 Dec 7;23(45):7945-7951.
Title:	Pancreatic acinar cell carcinoma: A review on molecular profiling of patient tumors.
Author:	Al-Hader, Ahmad\|Al-Rohil, Rami N\|Han, Haiyong\|Von Hoff, Daniel
PMID:	29259370

441.
Journal:	Cancer Biomark. 2018 Feb 6;21(2):323-334.
Title:	Long-term survivors of pancreatic adenocarcinoma show low rates of genetic alterations in KRAS, TP53 and SMAD4.
Author:	Masetti, Michele\|Acquaviva, Giorgia\|Visani, Michela\|Tallini, Giovanni\|Fornelli, Adele\|Ragazzi, Moira\|Vasuri, Francesco\|Grifoni, Daniela\|Di Giacomo, Simone\|Fiorino, Sirio\|Lombardi, Raffaele\|Tuminati, David\|Ravaioli, Matteo\|Fabbri, Carlo\|Bacchi-Reggiani, Ma
PMID:	29103024

442.
Journal:	Int J Radiat Oncol Biol Phys. 2018 Feb 1;100(2):490-497.
Title:	Prognostic Value of c-MET Expression in Patients With Pancreatic Cancer Receiving Adjuvant and Neoadjuvant Chemoradiation Therapy.
Author:	Cuneo, Kyle C\|Morgan, Meredith A\|Griffith, Kent A\|Hawkins, Peter G\|Greenson, Joel K\|Ben-Josef, Edgar\|Lawrence, Theodore S\|Zalupski, Mark M
PMID:	29229329

443.
Journal:	J Cancer. 2018 Jan 1;9(1):21-31.
Title:	Integrated Analysis of Long Non-Coding RNA and mRNA Expression Profile in Pancreatic Cancer Derived Exosomes Treated Dendritic Cells by Microarray Analysis.
Author:	Chen, Jionghuang\|Wang, Shaowen\|Jia, Shengnan\|Ding, Guoping\|Jiang, Guixing\|Cao, Liping
PMID:	29290766

444.
Journal:	Clin Cancer Res. 2018 Jun 15;24(12):2963-2974.
Title:	Pancreatic Juice Mutation Concentrations Can Help Predict the Grade of Dysplasia in Patients Undergoing Pancreatic Surveillance.
Author:	Suenaga, Masaya\|Yu, Jun\|Shindo, Koji\|Tamura, Koji\|Almario, Jose Alejandro\|Zaykoski, Christopher\|Witmer, P Dane\|Fesharakizadeh, Shahriar\|Borges, Michael\|Lennon, Anne-Marie\|Shin, Eun-Ji\|Canto, Marcia Irene\|Goggins, Michael
PMID:	29301828

445.
Journal:	Cell Stem Cell. 2018 Mar 1;22(3):454-467.e6.
Title:	Human Pancreatic Tumor Organoids Reveal Loss of Stem Cell Niche Factor Dependence during Disease Progression.
Author:	Seino, Takashi\|Kawasaki, Shintaro\|Shimokawa, Mariko\|Tamagawa, Hiroki\|Toshimitsu, Kohta\|Fujii, Masayuki\|Ohta, Yuki\|Matano, Mami\|Nanki, Kosaku\|Kawasaki, Kenta\|Takahashi, Sirirat\|Sugimoto, Shinya\|Iwasaki, Eisuke\|Takagi, Junichi\|Itoi, Takao\|Kitago, Minoru\|Kit
PMID:	29337182

446.
Journal:	Int J Oncol. 2018 Mar;52(3):892-900.
Title:	Endoglin (CD105) and SMAD4 regulate spheroid formation and the suppression of the invasive ability of human pancreatic cancer cells.
Author:	Kokaji, Eri\|Shimomura, Akiko\|Minamisaka, Takashi\|Nakajima, Takahiko\|Miwa, Shigeharu\|Hatta, Hideki\|Nishida, Takeshi\|Kiya, Chieko\|Imura, Johji
PMID:	29393426

447.
Journal:	Pancreas. 2018 Apr;47(4):502-510.
Title:	Site-Specific Genomic Alterations in a Well-Differentiated Pancreatic Neuroendocrine Tumor With High-Grade Progression.
Author:	Martin, David R\|LaBauve, Elisa\|Pomo, Joseph M\|Chiu, Vi K\|Hanson, Joshua A\|Gullapalli, Rama R
PMID:	29521944

448.
Journal:	Clin Cancer Res. 2018 Jul 1;24(13):3176-3185.
Title:	SMAD4 Gene Mutation Renders Pancreatic Cancer Resistance to Radiotherapy through Promotion of Autophagy.
Author:	Wang, Feng\|Xia, Xiaojun\|Yang, Chunying\|Shen, Jianliang\|Mai, Junhua\|Kim, Han-Cheon\|Kirui, Dickson\|Kang, Ya'an\|Fleming, Jason B\|Koay, Eugene J\|Mitra, Sankar\|Ferrari, Mauro\|Shen, Haifa
PMID:	29602802

449.
Journal:	Clin Cancer Res. 2018 Sep 15;24(18):4444-4454.
Title:	Integrated Genomic and Immunophenotypic Classification of Pancreatic Cancer Reveals Three Distinct Subtypes with Prognostic/Predictive Significance.
Author:	Wartenberg, Martin\|Cibin, Silvia\|Zlobec, Inti\|Vassella, Erik\|Eppenberger-Castori, Serenella\|Terracciano, Luigi\|Eichmann, Micha David\|Worni, Mathias\|Gloor, Beat\|Perren, Aurel\|Karamitopoulou, Eva
PMID:	29661773

450.
Journal:	Mol Carcinog. 2018 Sep;57(9):1102-1115.
Title:	Dual role of Par-4 in abrogation of EMT and switching on Mesenchymal to Epithelial Transition (MET) in metastatic pancreatic cancer cells.
Author:	Katoch, Archana\|Suklabaidya, Sujit\|Chakraborty, Souneek\|Nayak, Debasis\|Rasool, Reyaz U\|Sharma, Deepak\|Mukherjee, Debaraj\|Faheem, Mir M\|Kumar, Anmol\|Sharma, Parduman R\|Senapati, Shantibhusan\|Kumar, Lekha D\|Goswami, Anindya
PMID:	29672923

451.
Journal:	J Gastrointest Cancer. 2018 Apr 20. pii: 10.1007/s12029-018-0103-6.
Title:	Intratumoral Heterogeneity of SMAD4 Immunohistochemical Expression and Its Role in Prediction of Recurrence Pattern in Patients with Resectable Pancreatic Cancer.
Author:	Pokataev, Ilya\|Kudaibergenova, Asel\|Artemyeva, Anna\|Popova, Anna\|Rumyantsev, Alexey\|Podluzhny, Danil\|Kudashkin, Nikolay\|Fedyanin, Mikhail\|Tryakin, Alexey\|Tjulandin, Sergey
PMID:	29675723

452.
Journal:	J Clin Pathol. 2018 Aug;71(8):661-664.
Title:	Smad4/DPC4.
Author:	McCarthy, Aoife J\|Chetty, Runjan
PMID:	29720405

453.
Journal:	Oncol Rep. 2018 Aug;40(2):1093-1102.
Title:	Long noncoding RNA PVT1 promotes epithelialmesenchymal transition via the TGFbeta/Smad pathway in pancreatic cancer cells.
Author:	Zhang, Xingxing\|Feng, Wen\|Zhang, Jin\|Ge, Lu\|Zhang, Youli\|Jiang, Xiaomeng\|Peng, Wanxin\|Wang, Dawei\|Gong, Aihua\|Xu, Min
PMID:	29845201

454.
Journal:	Mol Cell Biochem. 2018 Jun 19. pii: 10.1007/s11010-018-3372-2.
Title:	Correlation between S100A11 and the TGF-beta1/SMAD4 pathway and its effects on the proliferation and apoptosis of pancreatic cancer cell line PANC-1.
Author:	Ji, Yi-Fei\|Li, Tao\|Jiang, Feng\|Ni, Wen-Kai\|Guan, Cheng-Qi\|Liu, Zhao-Xiu\|Lu, Cui-Hua\|Ni, Run-Zhou\|Wu, Wei\|Xiao, Ming-Bing
PMID:	29922945

455.
Journal:	Cancers (Basel). 2018 Jul 31;10(8). pii: cancers10080254.
Title:	TGF-betaRII Knock-down in Pancreatic Cancer Cells Promotes Tumor Growth and Gemcitabine Resistance. Importance of STAT3 Phosphorylation on S727.
Author:	Drubay, Vincent\|Skrypek, Nicolas\|Cordiez, Lucie\|Vasseur, Romain\|Schulz, Celine\|Boukrout, Nihad\|Duchene, Belinda\|Coppin, Lucie\|Van Seuningen, Isabelle\|Jonckheere, Nicolas
PMID:	30065235

456.
Journal:	Pathobiology. 2018 Sep 18:1-6.
Title:	Early Loss of Forkhead Transcription Factor, O Subgroup, Member 1 Protein in the Development of Pancreatic Ductal Adenocarcinoma.
Author:	Al-Zoughbi, Wael\|Schauer, Silvia\|Pichler, Martin\|Hoefler, Gerald
PMID:	30227407

457.
Journal:	Mol Cancer Ther. 2018 Oct 9. pii: 1535-7163.MCT-17-1298.
Title:	Monitoring tumor burden in response to FOLFIRINOX chemotherapy via profiling circulating cell-free DNA in pancreatic cancer.
Author:	Wei, Tao\|Zhang, Qi\|Li, Xiang\|Su, Wei\|Li, Guogang\|Ma, Tao\|Gao, Shunliang\|Lou, Jianying\|Que, Risheng\|Zheng, Lei\|Bai, Xueli\|Liang, Tingbo
PMID:	30301865