Primary Site >> Pancreatic Cancer
Gene >> SMAD4
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Ref: DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. PMID: 8553070 Ref: Homozygous deletion map at 18q21.1 in pancreatic cancer. PMID: 8564959 Ref: A human Mad protein acting as a BMP-regulated transcriptional activator. PMID: 8637600 Ref: DPC4, a candidate tumor suppressor gene, is altered infrequently in head and neck squamous cell carcinoma. PMID: 8653689 Ref: DPC4 gene in various tumor types. PMID: 8653691 Ref: MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma. PMID: 8752209 Ref: Somatic alterations of the DPC4 gene in human colorectal cancers in vivo. PMID: 8898652 Ref: Infrequent DPC4 gene mutation in esophageal cancer, gastric cancer and ulcerative colitis-associated neoplasms. PMID: 8957088 |
Ref: Genomic sequencing of DPC4 in the analysis of familial pancreatic carcinoma. PMID: 9098646 Ref: Heteromeric and homomeric interactions correlate with signaling activity and functional cooperativity of Smad3 and Smad4/DPC4. PMID: 9111321 Ref: Tumor-suppressive pathways in pancreatic carcinoma. PMID: 9135016 Ref: Analysis of the DPC4 gene in gastric carcinoma. PMID: 9197522 Ref: Molecular diagnosis of pancreas carcinoma. PMID: 9219065 Ref: [Molecular diagnosis of pancreatic cancer]. PMID: 9276865 Ref: Expression and mutational analysis of the DCC, DPC4, and MADR2/JV18-1 genes in neuroblastoma. PMID: 9288786 Ref: Induction of p21waf1 expression and growth inhibition by transforming growth factor beta involve the tumor suppressor gene DPC4 in human pancreatic adenocarcinoma cells. PMID: 9307274 Ref: Induction of apoptosis by DPC4, a transcriptional factor regulated by transforming growth factor-beta through stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) signaling pathway. PMID: 9312063 Ref: Inactivation of Smad4 in gastric carcinomas. PMID: 9331080 Ref: Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes. PMID: 9389648 Ref: Molecular advances in pancreatic cancer. PMID: 9438601 |
Ref: The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo. PMID: 9420335 Ref: Genetics of pancreatic cancer. From genes to families. PMID: 9443984 Ref: Role of growth factors in pancreatic cancer. PMID: 9443985 Ref: Up-regulation of transforming growth factor (TGF)-beta receptors by TGF-beta1 in COLO-357 cells. PMID: 9516449 Ref: Alterations in pancreatic, biliary, and breast carcinomas support MKK4 as a genetically targeted tumor suppressor gene. PMID: 9622070 Ref: Molecular pattern of ductal pancreatic cancer. PMID: 9641882 Ref: Mutational analysis of the tumor suppressor Smad2 in acute lymphoid and myeloid leukemia. PMID: 9665198 Ref: Cytogenetic and FISH analyses of pancreatic carcinoma reveal breaks in 18q11 with consistent loss of 18q12-qter and frequent gain of 18p. PMID: 9667665 Ref: Recent discoveries in cancer genetics of exocrine pancreatic neoplasia. PMID: 9705534 Ref: Occurrence, trends and environment etiology of pancreatic cancer. PMID: 9710368 Ref: Transfection of the type I TGF-beta receptor restores TGF-beta responsiveness in pancreatic cancer. PMID: 9754660 Ref: Disruption of the antiproliferative TGF-beta signaling pathways in human pancreatic cancer cells. PMID: 9788440 Ref: The molecular and cellular biology of pancreatic cancer. PMID: 9807701 Ref: Genetic alterations of the transforming growth factor beta receptor genes in pancreatic and biliary adenocarcinomas. PMID: 9850059 Ref: [SMAD4/DPC4 (small mothers against decapentaplegic deleted in pancreatic carcinoma, locus 4). Tumor suppressor gene]. PMID: 9867367 |
Ref: Molecular analyses of the 15q and 18q SMAD genes in pancreatic cancer. PMID: 9892110 Ref: Cooperative binding of Smad proteins to two adjacent DNA elements in the plasminogen activator inhibitor-1 promoter mediates transforming growth factor beta-induced smad-dependent transcriptional activation. PMID: 10092624 Ref: Immunohistochemical and molecular analysis of giant cell carcinoma of the pancreas: a report of three cases. PMID: 10206490 Ref: Bone morphogenetic protein 2 exerts diverse effects on cell growth in vitro and is expressed in human pancreatic cancer in vivo. PMID: 10220513 Ref: Ligand induced upregulation of the type II transforming growth factor (TGF-beta) receptor enhances TGF-beta responsiveness in COLO-357 cells. PMID: 10231841 Ref: Mutations of the DPC4/Smad4 gene in neuroendocrine pancreatic tumors. PMID: 10327057 Ref: DPC4/SMAD4 mediated tumor suppression of colon carcinoma cells is associated with reduced urokinase expression. PMID: 10340387 Ref: Malignant fibrous histiocytoma of the pancreas: a case report with genetic analysis. PMID: 10357405 Ref: Prognosis of human pancreatic adenocarcinoma: review of clinical and histopathological variables and possible uses of new molecular methods. PMID: 10365829 Ref: Higher frequency of DPC4/Smad4 alterations in pancreatic cancer cell lines than in primary pancreatic adenocarcinomas. PMID: 10408907 Ref: Tumor suppressor gene Smad4/DPC4, its downstream target genes, and regulation of cell cycle. PMID: 10415848 Ref: Molecular pathology of invasive carcinoma. PMID: 10415852 Ref: Orthotopic models of human pancreatic cancer. PMID: 10415855 Ref: Growth factors and cytokines in pancreatic carcinogenesis. PMID: 10415856 Ref: Progress in cancer genetics: lessons from pancreatic cancer. PMID: 10436774 Ref: DPC4/SMAD4 gene alterations in human cancer, and their functional implications. PMID: 10436786 Ref: Biliopancreatic malignancy: screening the at risk patient with molecular markers. PMID: 10436811 Ref: Molecular aspects of pancreatic cancer and future perspectives. PMID: 10449972 Ref: Inactivation of both alleles of the DPC4/SMAD4 gene in advanced colorectal cancers: identification of seven novel somatic mutations in tumors from Japanese patients. PMID: 10479724 Ref: Transforming growth factor-beta responsiveness in DPC4/SMAD4-null cancer cells. PMID: 10487520 Ref: The TGF-beta signaling inhibitor Smad7 enhances tumorigenicity in pancreatic cancer. PMID: 10498890 Ref: Overexpression of Smad2 and colocalization with TGF-beta1 in human pancreatic cancer. PMID: 10505717 Ref: Gastric and duodenal polyps in Smad4 (Dpc4) knockout mice. PMID: 10626800 Ref: Intracellular signaling of the TGF-beta superfamily by Smad proteins. PMID: 10667205 Ref: Molecular genetics and related developments in pancreatic cancer. PMID: 17023981 |
Ref: Immunohistochemical labeling for dpc4 mirrors genetic status in pancreatic adenocarcinomas : a new marker of DPC4 inactivation. PMID: 10623651 Ref: DCC and SMAD4 alterations in human colorectal and pancreatic tumor dissemination. PMID: 10698524 Ref: Homozygous deletions inactivate DCC, but not MADH4/DPC4/SMAD4, in a subset of pancreatic and biliary cancers. PMID: 10719364 Ref: [General rules for the study of pancreatic cancer by molecular biological aspect]. PMID: 10734643 Ref: TIEG proteins join the Smads as TGF-beta-regulated transcription factors that control pancreatic cell growth. PMID: 10762604 Ref: Loss of expression of Dpc4 in pancreatic intraepithelial neoplasia: evidence that DPC4 inactivation occurs late in neoplastic progression. PMID: 10766191 Ref: Differential expression of transforming growth factor beta receptors in human pancreatic adenocarcinoma. PMID: 10769633 Ref: Haploid loss of the tumor suppressor Smad4/Dpc4 initiates gastric polyposis and cancer in mice. PMID: 10773876 Ref: Mutations in the tumor suppressors Smad2 and Smad4 inactivate transforming growth factor beta signaling by targeting Smads to the ubiquitin-proteasome pathway. PMID: 10781087 Ref: Germline mutations of the dpc4 gene in Korean juvenile polyposis patients. PMID: 10797267 Ref: Anomalies of the TGF-beta postreceptor signaling pathway in ovarian cancer cell lines. PMID: 10810347 Ref: Characterization of a newly established human pancreatic carcinoma cell line, UK Pan-1. PMID: 10813711 Ref: Disruption of TGFbeta signaling pathways in human pancreatic cancer cells. PMID: 10862198 Ref: Molecular analysis of microdissected tumors and preneoplastic intraductal lesions in pancreatic carcinoma. PMID: 10880379 Ref: Smad4/DPC4-mediated tumor suppression through suppression of angiogenesis. PMID: 10944227 Ref: Association of poor prognosis with loss of 12q, 17p, and 18q, and concordant loss of 6q/17p and 12q/18q in human pancreatic ductal adenocarcinoma. PMID: 10950061 Ref: Reassessment of K-ras mutations at codon 12 by direct PCR and sequencing from tissue microdissection in human pancreatic adenocarcinomas. PMID: 10975709 Ref: Dpc-4 protein is expressed in virtually all human intraductal papillary mucinous neoplasms of the pancreas: comparison with conventional ductal adenocarcinomas. PMID: 10980115 Ref: No SMAD4 hypermethylation in colorectal cancer. PMID: 10993648 Ref: TGFbeta1 represses proliferation of pancreatic carcinoma cells which correlates with Smad4-independent inhibition of ERK activation. PMID: 11002426 Ref: The 18q21 region in colorectal and pancreatic cancer: independent loss of DCC and DPC4 expression. PMID: 11040453 Ref: Dpc4 protein in mucinous cystic neoplasms of the pancreas: frequent loss of expression in invasive carcinomas suggests a role in genetic progression. PMID: 11075857 Ref: Pancreatic cancer--new aspects of molecular biology research. PMID: 11077487 Ref: [Detection of alterations of the DPC4 gene in paraffin-embedded tissues of pancreatic carcinomas]. PMID: 11866919 Ref: Expression of Smad4 Gene in Pichia pastoris and Identification of the Protein. PMID: 12075447 Ref: Molecular genetics of ductal pancreatic neoplasia. PMID: 17031113 |
Ref: Characterization of the mutations of the K-ras, p53, p16, and SMAD4 genes in 15 human pancreatic cancer cell lines. PMID: 11115575 Ref: Growth factors and their receptors in pancreatic cancer. PMID: 11135319 Ref: A murine tumor progression model for pancreatic cancer recapitulating the genetic alterations of the human disease. PMID: 11159909 Ref: Pancreatic tumours: molecular pathways implicated in ductal cancer are involved in ampullary but not in exocrine nonductal or endocrine tumorigenesis. PMID: 11161385 Ref: Non-random chromosomal rearrangements in pancreatic cancer cell lines identified by spectral karyotyping. PMID: 11169959 Ref: ACVR1B (ALK4, activin receptor type 1B) gene mutations in pancreatic carcinoma. PMID: 11248065 Ref: Transcriptional activation of mouse sst2 somatostatin receptor promoter by transforming growth factor-beta. Involvement of Smad4. PMID: 11278805 Ref: High-throughput drug screening of the DPC4 tumor-suppressor pathway in human pancreatic cancer cells. PMID: 11323508 Ref: Exclusion of SMAD4 mutation as an early genetic change in human pancreatic ductal tumorigenesis. PMID: 11391801 Ref: Altered expression of TGFB receptors and mitogenic effects of TGFB in pancreatic carcinomas. PMID: 11408925 Ref: TGF-beta-induced invasiveness of pancreatic cancer cells is mediated by matrix metalloproteinase-2 and the urokinase plasminogen activator system. PMID: 11410867 Ref: The immunohistochemical mucin expression pattern distinguishes different types of intraductal papillary mucinous neoplasms of the pancreas and determines their relationship to mucinous noncystic carcinoma and ductal adenocarcinoma. PMID: 11420467 Ref: Molecular diagnosis of pancreatic cancer. PMID: 11490843 Ref: Loss of Smad4 function in pancreatic tumors: C-terminal truncation leads to decreased stability. PMID: 11553622 Ref: Molecular pathology of pancreatic cancer. PMID: 11561601 Ref: Distinctive molecular genetic alterations in sporadic and familial adenomatous polyposis-associated pancreatoblastomas : frequent alterations in the APC/beta-catenin pathway and chromosome 11p. PMID: 11696422 Ref: Systematic analysis of the TGF-beta-Smad signaling pathway in gastrointestinal cancer cells. PMID: 11716479 Ref: Overexpression of p21(WAF1/CIP1) is an early event in the development of pancreatic intraepithelial neoplasia. PMID: 11751405 Ref: SMAD4/DPC4 and pancreatic cancer survival. Commentary re: M. Tascilar et al., The SMAD4 protein and prognosis of pancreatic ductal adenocarcinoma. Clin. Cancer Res., 7: 4115-4121, 2001. PMID: 11751474 Ref: The SMAD4 protein and prognosis of pancreatic ductal adenocarcinoma. PMID: 11751510 Ref: [Alterations in DPC4 gene in pancreatic cancers]. PMID: 11783110 Ref: Genetic profile of 22 pancreatic carcinoma cell lines. Analysis of K-ras, p53, p16 and DPC4/Smad4. PMID: 11787853 Ref: [Detection of the expression of Smad4, transforming growth factor beta(1) and beta receptor II proteins in paraffin-embedded human pancreatic cancer tissues]. PMID: 11866987 Ref: TGF alpha transgenic mice. A model of pancreatic cancer development. PMID: 12120215 Ref: An Epidemiological Overview of Environmental and Genetic Risk Factors of Pancreatic Cancer. PMID: 12718618 |
Ref: Genetic and immunohistochemical analysis of pancreatic acinar cell carcinoma: frequent allelic loss on chromosome 11p and alterations in the APC/beta-catenin pathway. PMID: 11891193 Ref: The mucin profile of noninvasive and invasive mucinous cystic neoplasms of the pancreas. PMID: 11914624 Ref: Solid-pseudopapillary tumors of the pancreas are genetically distinct from pancreatic ductal adenocarcinomas and almost always harbor beta-catenin mutations. PMID: 11943721 Ref: Direct correlation between proliferative activity and dysplasia in pancreatic intraepithelial neoplasia (PanIN): additional evidence for a recently proposed model of progression. PMID: 11950919 Ref: Application of molecular biology studies to gene therapy treatment strategies. PMID: 11960211 Ref: Suppression of the tumorigenic phenotype by chromosome 18 transfer into pancreatic cancer cell lines. PMID: 11979557 Ref: Aberrant p16(INK4A) and DPC4/Smad4 expression in intraductal papillary mucinous tumours of the pancreas is associated with invasive ductal adenocarcinoma. PMID: 12010891 Ref: Molecular prognostic markers in pancreatic cancer. PMID: 12021893 Ref: Gene therapy for pancreatic cancer based on genetic characterization of the disease. PMID: 12021895 Ref: Establishment and characterization of four human pancreatic carcinoma cell lines. Genetic alterations in the TGFBR2 gene but not in the MADH4 gene. PMID: 12037578 Ref: Molecular pathogenesis of pancreatic cancer. PMID: 12063826 Ref: Frequent loss of SMAD4/DPC4 protein in colorectal cancers. PMID: 12077092 Ref: Genetic basis of pancreatic cancer. PMID: 12079267 Ref: [Genetics of pancreatic cancer: recent advances in molecular diagnosis]. PMID: 12094699 Ref: Carcinogen-induced pancreatic lesions in the mouse: effect of Smad4 and Apc genotypes. PMID: 12096346 Ref: Evaluation of candidate genes MAP2K4, MADH4, ACVR1B, and BRCA2 in familial pancreatic cancer: deleterious BRCA2 mutations in 17%. PMID: 12097290 Ref: Ampulla of vater cancers: T-stage and histological subtype but not Dpc4 expression predict prognosis. PMID: 12111196 Ref: Frequent deletions of tumor suppressor genes in pure pancreatic juice from patients with tumoral or nontumoral pancreatic diseases. PMID: 12120000 Ref: Smad4/DPC4-dependent regulation of biglycan gene expression by transforming growth factor-beta in pancreatic tumor cells. PMID: 12140283 Ref: TGFbeta inducible early gene enhances TGFbeta/Smad-dependent transcriptional responses. PMID: 12173049 Ref: Cytokeratins 7 and 20, Dpc4, and MUC5AC in the distinction of metastatic mucinous carcinomas in the ovary from primary ovarian mucinous tumors: Dpc4 assists in identifying metastatic pancreatic carcinomas. PMID: 12352188 Ref: Induction and expression of betaig-h3 in pancreatic cancer cells. PMID: 12379307 Ref: Restoration of transforming growth factor Beta signaling by functional expression of smad4 induces anoikis. PMID: 12414627 Ref: Suppression of tumorigenesis and induction of p15(ink4b) by Smad4/DPC4 in human pancreatic cancer cells. PMID: 12429655 Ref: DPC4/Smad4 expression and outcome in pancreatic ductal adenocarcinoma. PMID: 12454109 Ref: [Expression of DPC4/Smad4, p21wafI, and p16 in human pancreatic cancer]. PMID: 12479060 Ref: [Molecular pathways of pancreatic carcinogenesis]. PMID: 12483152 Ref: Pancreatic cancer: epidemiology, genetics, and approaches to screening. PMID: 12520639 Ref: Minute invasive ductal carcinoma of the residual pancreas after distal pancreatectomy for intraductal papillary-mucinous tumor. PMID: 12622431 Ref: Gene therapy for pancreatic cancer targeting the genomic alterations of tumor suppressor genes using replication-selective oncolytic adenovirus. PMID: 12703544 Ref: [Alterations of DPC4/SMAD4/MADH4 gene detected in paraffin-embedded tissues of human pancreatic carcinomas]. PMID: 12905795 Ref: The relationship between loss expression of DPC4/Smad4 gene and carcinogenesis of pancreatobiliary carcinoma. PMID: 14607700 |
Ref: Rap1 reverses transcriptional repression of TGF-beta type II receptor by a mechanism involving AP-1 in the human pancreatic cancer cell line, UK Pan-1. PMID: 12447993 Ref: Differential roles of alterations of p53, p16, and SMAD4 expression in the progression of intraductal papillary-mucinous tumors of the pancreas. PMID: 12469138 Ref: Tumor-suppressing pathways in cystic pancreatic tumors. PMID: 12499916 Ref: Genetic abnormalities in pancreatic cancer. PMID: 12537585 Ref: Infrequent mutation of the tumour-suppressor gene Smad4 in early-stage colorectal cancer. PMID: 12569386 Ref: Genetic alterations in pancreatic carcinoma. PMID: 12605716 Ref: TGF-beta-induced nuclear localization of Smad2 and Smad3 in Smad4 null cancer cell lines. PMID: 12618756 Ref: Pancreatic carcinoma cell lines with SMAD4 inactivation show distinct expression responses to TGFB1. PMID: 12619158 Ref: [Pancreatic carcinogenesis. Clinical implications]. PMID: 12647072 Ref: A comprehensive characterization of pancreatic ductal carcinoma cell lines: towards the establishment of an in vitro research platform. PMID: 12692724 Ref: Systematic isolation of genes differentially expressed in normal and cancerous tissue of the pancreas. PMID: 12748427 Ref: A clinically relevant model of human pancreatic adenocarcinoma identifies patterns of metastasis associated with alterations of the TGF-beta/Smad4 signaling pathway. PMID: 12909738 Ref: Laser microdissection of small tissue samples--application to chronic pancreatitis tissues. PMID: 12924436 Ref: The genetics of pancreatic cancer. PMID: 12946833 Ref: Multicomponent analysis of the pancreatic adenocarcinoma progression model using a pancreatic intraepithelial neoplasia tissue microarray. PMID: 13679454 Ref: Loss of Smad4 protein expression occurs infrequently in endometrial carcinomas. PMID: 14501814 Ref: Clinicopathological features of pancreatic intraepithelial neoplasias and their relationship to intraductal papillary-mucinous tumors. PMID: 14505145 Ref: Pancreatic carcinoma in carriers of a specific 19 base pair deletion of CDKN2A/p16 (p16-leiden). PMID: 14506146 Ref: SEL1L expression in pancreatic adenocarcinoma parallels SMAD4 expression and delays tumor growth in vitro and in vivo. PMID: 14508516 Ref: Inserting chromosome 18 into pancreatic cancer cells switches them to a dormant metastatic phenotype. PMID: 14581380 Ref: p16 Inactivation in pancreatic intraepithelial neoplasias (PanINs) arising in patients with chronic pancreatitis. PMID: 14657708 Ref: Loss of DPC4 expression and its correlation with clinicopathological parameters in pancreatic carcinoma. PMID: 14669329 Ref: Surveillance for familial pancreatic cancer. PMID: 14743890 |
Ref: Alteration of somatostatin receptor subtype 2 gene expression in pancreatic tumor angiogenesis. PMID: 14695784 Ref: Molecular and functional consequences of Smad4 C-terminal missense mutations in colorectal tumour cells. PMID: 14715079 Ref: Smad4-independent regulation of p21/WAF1 by transforming growth factor-beta. PMID: 14762439 Ref: Blockage of intermediate-conductance Ca2+-activated K+ channels inhibit human pancreatic cancer cell growth in vitro. PMID: 14978241 Ref: Missense mutations of MADH4: characterization of the mutational hot spot and functional consequences in human tumors. PMID: 15014009 Ref: Microcystic tubulopapillary carcinoma of the pancreas: a new tumor entity? PMID: 15014986 Ref: Intraductal tubular adenoma, pyloric type, of the pancreas: additional observations on a new type of pancreatic neoplasm. PMID: 15043313 Ref: [Recent advances in gene change of pancreatic cancer]. PMID: 15052782 Ref: The role of chromosome 18 abnormalities in the progression of pancreatic adenocarcinoma. PMID: 15084978 Ref: Proteomic analysis of the TGF-beta signaling pathway in pancreatic carcinoma cells using stable RNA interference to silence Smad4 expression. PMID: 15110786 Ref: Ductuloinsular tumors of the pancreas: endocrine tumors with entrapped nonneoplastic ductules. PMID: 15166675 Ref: A role for human MUC4 mucin gene, the ErbB2 ligand, as a target of TGF-beta in pancreatic carcinogenesis. PMID: 15184872 Ref: [TGF-beta signaling pathway in pancreatic cancer cells]. PMID: 15283139 Ref: Targeting endogenous transforming growth factor beta receptor signaling in SMAD4-deficient human pancreatic carcinoma cells inhibits their invasive phenotype1. PMID: 15289325 Ref: Orthotopic transplantation models of pancreatic adenocarcinoma derived from cell lines and primary tumors and displaying varying metastatic activity. PMID: 15367885 Ref: p53 and DPC4 alterations in the bile of patients with pancreatic carcinoma. PMID: 15565642 |
Ref: Smad4 silencing in pancreatic cancer cell lines using stable RNA interference and gene expression profiles induced by transforming growth factor-beta. PMID: 15592526 Ref: Immunohistochemistry as a tool in the differential diagnosis of ovarian tumors: an update. PMID: 15626916 Ref: Expression of mesothelin, fascin, and prostate stem cell antigen in primary ovarian mucinous tumors and their utility in differentiating primary ovarian mucinous tumors from metastatic pancreatic mucinous carcinomas in the ovary. PMID: 15626919 Ref: Effect of deleted pancreatic cancer locus 4 gene transfection on biological behaviors of human colorectal carcinoma cells. PMID: 15637742 Ref: Mucinous cystic carcinoma of the pancreas: a unique cell line and xenograft model of a preinvasive lesion. PMID: 15688169 Ref: Expression of novel markers of pancreatic ductal adenocarcinoma in pancreatic nonductal neoplasms: additional evidence of different genetic pathways. PMID: 15696124 Ref: Intestinal and oncocytic variants of pancreatic intraepithelial neoplasia. A morphological and immunohistochemical study. PMID: 15806512 Ref: MUC1 overexpression is the most reliable marker of invasive carcinoma in intraductal papillary-mucinous tumor (IPMT). PMID: 15816444 Ref: Distinct progression pathways involving the dysfunction of DUSP6/MKP-3 in pancreatic intraepithelial neoplasia and intraductal papillary-mucinous neoplasms of the pancreas. PMID: 15832194 Ref: High nuclear S100A6 (Calcyclin) is significantly associated with poor survival in pancreatic cancer patients. PMID: 15833853 Ref: Immortalizing the complexity of cancer metastasis: genetic features of lethal metastatic pancreatic cancer obtained from rapid autopsy. PMID: 15846069 Ref: SCF(beta-TrCP1) controls Smad4 protein stability in pancreatic cancer cells. PMID: 15855639 Ref: Biological similarities and differences between pancreatic intraepithelial neoplasias and intraductal papillary mucinous neoplasms. PMID: 15879625 Ref: Analysis of genomic DNA alterations and mRNA expression patterns in a panel of human pancreatic cancer cell lines. PMID: 15929091 Ref: In vitro modeling of human pancreatic duct epithelial cell transformation defines gene expression changes induced by K-ras oncogenic activation in pancreatic carcinogenesis. PMID: 15958547 Ref: Smad4 dependency defines two classes of transforming growth factor {beta} (TGF-{beta}) target genes and distinguishes TGF-{beta}-induced epithelial-mesenchymal transition from its antiproliferative and migratory responses. PMID: 16135802 Ref: Vascular endothelial growth factor and DPC4 predict adjuvant therapy outcomes in resected pancreatic cancer. PMID: 16137582 Ref: Molecular prognostic markers in pancreatic cancer: a systematic review. PMID: 16146690 Ref: Killer genes in pancreatic cancer therapy. PMID: 16171565 Ref: Ductal neoplasia of the pancreas: nosologic, clinicopathologic, and biologic aspects. PMID: 16183479 Ref: TGFbeta-induced downregulation of E-cadherin-based cell-cell adhesion depends on PI3-kinase and PTEN. PMID: 16219695 Ref: [Influence of Smad4-independent pathway of transforming growth factor beta1 on the biological activity of pancreatic cancer cells]. PMID: 16251046 Ref: Restoration of Smad4 in BxPC3 pancreatic cancer cells attenuates proliferation without altering angiogenesis. PMID: 16320109 |
Ref: Molecular mechanisms of pancreatic carcinogenesis. PMID: 16367914 Ref: Distribution of breakpoints on chromosome 18 in breast, colorectal, and pancreatic carcinoma cell lines. PMID: 16434311 Ref: Molecular pathogenesis of pancreatic cancer. PMID: 16549325 Ref: Yes-associated protein (YAP65) in relation to Smad7 expression in human pancreatic ductal adenocarcinoma. PMID: 16596258 Ref: Smad4 signalling in T cells is required for suppression of gastrointestinal cancer. PMID: 16791201 Ref: Molecular pathogenesis of pancreatic adenocarcinoma: potential clinical implications. PMID: 16940943 Ref: Identification of an agent selectively targeting DPC4 (deleted in pancreatic cancer locus 4)-deficient pancreatic cancer cells. PMID: 17018631 Ref: [Pancreatic cancer]. PMID: 17111879 Ref: Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer. PMID: 17114584 |
Ref: Basement membrane component laminin-5 is a target of the tumor suppressor Smad4. PMID: 16953227 Ref: Smad4 is essential for down-regulation of E-cadherin induced by TGF-beta in pancreatic cancer cell line PANC-1. PMID: 17301079 Ref: Kras(G12D) and Smad4/Dpc4 haploinsufficiency cooperate to induce mucinous cystic neoplasms and invasive adenocarcinoma of the pancreas. PMID: 17349581 Ref: The expression of S100A8 in pancreatic cancer-associated monocytes is associated with the Smad4 status of pancreatic cancer cells. PMID: 17469085 Ref: Pathogenesis of colorectal carcinoma and therapeutic implications: the roles of the ubiquitin-proteasome system and Cox-2. PMID: 17488476 Ref: Molecular genetics of pancreatic intraepithelial neoplasia. PMID: 17520196 Ref: Immunohistochemical expression of SMAD4, CK19, and CA19-9 in fine needle aspiration samples of pancreatic adenocarcinoma: Utility and potential role. PMID: 17587453 Ref: RAS/ERK modulates TGFbeta-regulated PTEN expression in human pancreatic adenocarcinoma cells. PMID: 17638924 Ref: Evaluation of clinical relevance of examining K-ras, p16 and p53 mutations along with allelic losses at 9p and 18q in EUS-guided fine needle aspiration samples of patients with chronic pancreatitis and pancreatic cancer. PMID: 17659731 Ref: Molecular pathogenesis of pancreatic cancer: advances and challenges. PMID: 17691965 Ref: Expression of connective tissue growth factor in pancreatic cancer cell lines. PMID: 17786299 Ref: High-level inducible Smad4-reexpression in the cervical cancer cell line C4-II is associated with a gene expression profile that predicts a preferential role of Smad4 in extracellular matrix composition. PMID: 17997817 Ref: Molecular cytogenetic characterization of pancreas cancer cell lines reveals high complexity chromosomal alterations. PMID: 18000365 |
Ref: Pancreatic cancer. PMID: 18039136 Ref: The PMAIP1 gene on chromosome 18 is a candidate tumor suppressor gene in human pancreatic cancer. PMID: 18231856 Ref: TGF-beta mediates PTEN suppression and cell motility through calcium-dependent PKC-alpha activation in pancreatic cancer cells. PMID: 18239055 Ref: Smad4-dependent TGF-beta signaling suppresses RON receptor tyrosine kinase-dependent motility and invasion of pancreatic cancer cells. PMID: 18310076 Ref: Functional blockade of Smad4 leads to a decrease in beta-catenin levels and signaling activity in human pancreatic carcinoma cells. PMID: 18310088 Ref: Role of the WWOX gene, encompassing fragile region FRA16D, in suppression of pancreatic carcinoma cells. PMID: 18460020 Ref: Inhibition of STAT3 Tyr705 phosphorylation by Smad4 suppresses transforming growth factor beta-mediated invasion and metastasis in pancreatic cancer cells. PMID: 18519681 Ref: [New molecular targets in pancreatic cancer]. PMID: 18541514 Ref: Pancreatic cancer: a plea for good and comprehensive morphological studies. PMID: 18617774 Ref: Establishment and molecular profiling of a novel human pancreatic cancer panel for 5-FU. PMID: 18691340 Ref: Molecular aspects of carcinogenesis in pancreatic cancer. PMID: 18693168 Ref: Differential expression of multiple genes in association with MADH4/DPC4/SMAD4 inactivation in pancreatic cancer. PMID: 18787631 Ref: Lentiviral-mediated Smad4 RNAi induced anti-proliferation by p16 up-regulation and apoptosis by caspase 3 down-regulation in hepatoma SMMC-7721 cells. PMID: 18949401 Ref: Inhibition of pancreatic carcinoma cell growth in vitro by DPC4 gene transfection. PMID: 18985820 Ref: Precursor lesions of pancreatic cancer. PMID: 20485640 |
Ref: Establishment and characterization of 4 new human pancreatic cancer cell lines: evidences of different tumor phenotypes. PMID: 19002021 Ref: Expression of the calcium-binding protein S100P is regulated by bone morphogenetic protein in pancreatic duct epithelial cell lines. PMID: 19018761 Ref: Mutational profiling of cancer candidate genes in glioblastoma, melanoma and pancreatic carcinoma reveals a snapshot of their genomic landscapes. PMID: 19058223 Ref: UA62784, a novel inhibitor of centromere protein E kinesin-like protein. PMID: 19139111 Ref: Low-level expression of Smad7 correlates with lymph node metastasis and poor prognosis in patients with pancreatic cancer. PMID: 19165547 Ref: The pathology and genetics of metastatic pancreatic cancer. PMID: 19260747 Ref: Adenosquamous carcinoma of the pancreas harbors KRAS2, DPC4 and TP53 molecular alterations similar to pancreatic ductal adenocarcinoma. PMID: 19270646 Ref: DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer. PMID: 19273710 Ref: Identification and characterization of a novel anticancer agent with selectivity against deleted in pancreatic cancer locus 4 (DPC4)-deficient pancreatic and colon cancer cells. PMID: 19276868 Ref: Genetic mutations associated with cigarette smoking in pancreatic cancer. PMID: 19351817 Ref: Hypermethylation-mediated reduction of WWOX expression in intraductal papillary mucinous neoplasms of the pancreas. PMID: 19352382 Ref: Intraductal tubulopapillary neoplasms of the pancreas distinct from pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms. PMID: 19440145 Ref: Mutation status of K-ras, p53 and allelic losses at 9p and 18q are not prognostic markers in patients with pancreatic cancer. PMID: 19443408 Ref: Dual role of Ski in pancreatic cancer cells: tumor-promoting versus metastasis-suppressive function. PMID: 19546161 Ref: SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer. PMID: 19584151 Ref: Inactivation of TIF1gamma cooperates with Kras to induce cystic tumors of the pancreas. PMID: 19629168 Ref: Promoter-wide analysis of Smad4 binding sites in human epithelial cells. PMID: 19686287 Ref: 4E-BP1 is a target of Smad4 essential for TGFbeta-mediated inhibition of cell proliferation. PMID: 19834456 Ref: Molecular pathology of pancreatic cancer: implications for molecular targeting therapy. PMID: 19896096 Ref: Differentiating neoplastic from benign lesions of the pancreas: translational techniques. PMID: 19896100 Ref: Alteration of SMAD4 does not participate in tumorigenesis of adenoid cystic carcinoma of the salivary gland. PMID: 21475783 |
Ref: Synergistic action of Smad4 and Pten in suppressing pancreatic ductal adenocarcinoma formation in mice. PMID: 19901970 Ref: TGF-beta downregulates PTEN via activation of NF-kappaB in pancreatic cancer cells. PMID: 19940030 Ref: Smad4-mediated TGF-beta signaling in tumorigenesis. PMID: 20087440 Ref: Pancreatic acinar cell carcinomas with prominent ductal differentiation: Mixed acinar ductal carcinoma and mixed acinar endocrine ductal carcinoma. PMID: 20182344 Ref: Phenotype and genotype of pancreatic cancer cell lines. PMID: 20418756 Ref: Extensive biliary intraepithelial neoplasia (BilIN) and multifocal early intrahepatic cholangiocarcinoma in non-biliary cirrhosis. PMID: 20428886 Ref: Genomic instability at both the base pair level and the chromosomal level is detectable in earliest PanIN lesions in tissues of chronic pancreatitis. PMID: 20531246 Ref: Analogs of vitamin E epitomized by alpha-tocopheryl succinate for pancreatic cancer treatment: in vitro results induce caution for in vivo applications. PMID: 20562578 Ref: Prioritization of driver mutations in pancreatic cancer using cancer-specific high-throughput annotation of somatic mutations (CHASM). PMID: 20581473 Ref: Smad4 loss is associated with fewer S100A8-positive monocytes in colorectal tumors and attenuated response to S100A8 in colorectal and pancreatic cancer cells. PMID: 20622003 Ref: FAK and interacting proteins as therapeutic targets in pancreatic cancer. PMID: 21235432 Ref: Molecular pathology of early pancreatic cancer. PMID: 22112488 |
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