Literatures

Primary Site >> Liver Cancer

Gene >> SMAD4

1.
Journal:	Oncogene. 1999 Aug 26;18(34):4879-83.
Title:	Smad2 and Smad4 gene mutations in hepatocellular carcinoma.
Author:	Yakicier, M C\|Irmak, M B\|Romano, A\|Kew, M\|Ozturk, M
PMID:	10490821

2.
Journal:	Int J Oncol. 1999 Jan;14(1):127-31.
Title:	Mutation analysis of transforming growth factor beta type II receptor, Smad2, and Smad4 in hepatocellular carcinoma.
Author:	Kawate, S\|Takenoshita, S\|Ohwada, S\|Mogi, A\|Fukusato, T\|Makita, F\|Kuwano, H\|Morishita, Y
PMID:	9863018

3.
Journal:	Genes Dev. 2001 Feb 15;15(4):455-66.
Title:	The hepatitis B virus encoded oncoprotein pX amplifies TGF-beta family signaling through direct interaction with Smad4: potential mechanism of hepatitis B virus-induced liver fibrosis.
Author:	Lee, D K\|Park, S H\|Yi, Y\|Choi, S G\|Lee, C\|Parks, W T\|Cho, H\|de Caestecker, M P\|Shaul, Y\|Roberts, A B\|Kim, S J
PMID:	11230153

4.
Journal:	Hum Pathol. 2002 Sep;33(9):871-6.
Title:	Smad4 overexpression in hepatocellular carcinoma is strongly associated with transforming growth factor beta II receptor immunolabeling.
Author:	Torbenson, Michael\|Marinopoulos, Spyridon\|Dang, Duyen T\|Choti, Michael\|Ashfaq, Raheela\|Maitra, Anirban\|Boitnott, John\|Wilentz, Robb E
PMID:	12378510

5.
Journal:	Oncogene. 2003 Apr 17;22(15):2309-21.
Title:	Distortion of autocrine transforming growth factor beta signal accelerates malignant potential by enhancing cell growth as well as PAI-1 and VEGF production in human hepatocellular carcinoma cells.
Author:	Sugano, Yasushi\|Matsuzaki, Koichi\|Tahashi, Yoshiya\|Furukawa, Fukiko\|Mori, Shigeo\|Yamagata, Hideo\|Yoshida, Katsunori\|Matsushita, Masanori\|Nishizawa, Mikio\|Fujisawa, Junichi\|Inoue, Kyoichi
PMID:	12700666

6.
Journal:	Hepatogastroenterology. 2004 Mar-Apr;51(56):396-400.
Title:	Expression of Smad7 in hepatocellular carcinoma and dysplastic nodules: resistance mechanism to transforming growth factor-beta.
Author:	Park, Young Nyun\|Chae, Kwang Jo\|Oh, Bong-Kyeong\|Choi, Jinsub\|Choi, Kyeong Sook\|Park, Chanil
PMID:	15086168

7.
Journal:	Virchows Arch. 2004 Dec;445(6):589-96.
Title:	Factors of transforming growth factor beta signalling are co-regulated in human hepatocellular carcinoma.
Author:	Longerich, Thomas\|Breuhahn, Kai\|Odenthal, Margarete\|Petmecky, Katharina\|Schirmacher, Peter
PMID:	15455231

8.
Journal:	J Mol Endocrinol. 2004 Oct;33(2):445-58.
Title:	Regulation of fibronectin by thyroid hormone receptors.
Author:	Lin, Kwang-Huei\|Chen, Chia-yu\|Chen, Shen-Liang\|Yen, Chun-Che\|Huang, Ya-Hui\|Shih, Chung-hsuan\|Shen, Jiann-Jong\|Yang, Rong-Chi\|Wang, Chia-Siu
PMID:	15525600

9.
Journal:	Zhonghua Wai Ke Za Zhi. 2005 Jun 1;43(11):721-5.
Title:	[The study of inhibition effect of octreotide on the growth of hepatocellular carcinoma xenografts in situ in nude mice].
Author:	Hua, Yun-peng\|Huang, Jie-fu\|Liang, Li-jian\|Li, Shao-qiang\|Lai, Jia-ming\|Liang, Hui-zhen
PMID:	16008961

10.
Journal:	Zhonghua Wai Ke Za Zhi. 2005 Jul 1;43(13):846-9.
Title:	[Expression of Smad4 and transforming growth factor-beta1, transforming growth factor-beta receptor II in cholangiocarcinoma tissue and its biological significance].
Author:	Zhang, Bing-yuan\|Zhang, Jian-yu\|Zhao, Kai\|Wu, Li-qun
PMID:	16083599

11.
Journal:	World J Gastroenterol. 2006 Jan 28;12(4):644-8.
Title:	Role of transforming growth factor-beta1-smad signal transduction pathway in patients with hepatocellular carcinoma.
Author:	Ji, Guo-Zhong\|Wang, Xue-Hao\|Miao, Lin\|Liu, Zheng\|Zhang, Ping\|Zhang, Fa-Ming\|Yang, Jian-Bing
PMID:	16489684

12.
Journal:	Beijing Da Xue Xue Bao Yi Xue Ban. 2006 Apr 18;38(2):176-8.
Title:	Apoptosis of human hepatoma cell lines induced by transforming growth factor beta 1 (TGF-beta1) correlates with p53 and Smad4 activation.
Author:	Wang, Chun-lei\|Wan, Yuan-lian\|Liu, Yu-cun\|Huang, Zhi-qiang
PMID:	16617361

13.
Journal:	Chin Med Sci J. 2006 Mar;21(1):33-5.
Title:	TGF-beta1/SMAD signaling pathway mediates p53-dependent apoptosis in hepatoma cell lines.
Author:	Wang, Chun-lei\|Wan, Yuan-lian\|Liu, Yu-cun\|Huang, Zhi-qiang
PMID:	16615282

14.
Journal:	J Biol Chem. 2006 Mar 17;281(11):7468-78.
Title:	Modulation of the transforming growth factor-beta signal transduction pathway by hepatitis C virus nonstructural 5A protein.
Author:	Choi, Soo-Ho\|Hwang, Soon B
PMID:	16407286

15.
Journal:	Oncogene. 2007 Nov 1;26(50):7103-10.
Title:	Disruption of transforming growth factor-beta signaling through beta-spectrin ELF leads to hepatocellular cancer through cyclin D1 activation.
Author:	Kitisin, K\|Ganesan, N\|Tang, Y\|Jogunoori, W\|Volpe, E A\|Kim, S S\|Katuri, V\|Kallakury, B\|Pishvaian, M\|Albanese, C\|Mendelson, J\|Zasloff, M\|Rashid, A\|Fishbein, T\|Evans, S R T\|Sidawy, A\|Reddy, E P\|Mishra, B\|Johnson, L B\|Shetty, K\|Mishra, L
PMID:	17546056

16.
Journal:	Hepatobiliary Pancreat Dis Int. 2008 Apr;7(2):174-8.
Title:	Expression of transforming growth factors in hepatocellular carcinoma and its relations with clinicopathological parameters and prognosis.
Author:	Lu, Yun\|Wu, Li-Qun\|Li, Chang-Sheng\|Wang, Shou-Guang\|Han, Bing
PMID:	18397854

17.
Journal:	Int J Cancer. 2008 Aug 15;123(4):972-8.
Title:	Upregulation of miR-23a approximately 27a approximately 24 decreases transforming growth factor-beta-induced tumor-suppressive activities in human hepatocellular carcinoma cells.
Author:	Huang, Shenglin\|He, Xianghuo\|Ding, Jie\|Liang, Linhui\|Zhao, Yingjun\|Zhang, Zhenfeng\|Yao, Xiao\|Pan, Zhimei\|Zhang, Pingping\|Li, Jinjun\|Wan, Dafang\|Gu, Jianren
PMID:	18508316

18.
Journal:	Mol Cancer Res. 2008 Jul;6(7):1169-77.
Title:	Transforming growth factor-beta-mediated tumor necrosis factor-related apoptosis-inducing ligand expression and apoptosis in hepatoma cells requires functional cooperation between Smad proteins and activator protein-1.
Author:	Herzer, Kerstin\|Grosse-Wilde, Anne\|Krammer, Peter H\|Galle, Peter R\|Kanzler, Stephan
PMID:	18644981

19.
Journal:	Oncol Rep. 2008 Nov;20(5):1053-9.
Title:	Lentiviral-mediated Smad4 RNAi induced anti-proliferation by p16 up-regulation and apoptosis by caspase 3 down-regulation in hepatoma SMMC-7721 cells.
Author:	Huang, Shu\|Zhang, Faming\|Miao, Lin\|Zhang, Huijie\|Fan, Zhining\|Wang, Xuehao\|Ji, Guozhong
PMID:	18949401

20.
Journal:	Nan Fang Yi Ke Da Xue Xue Bao. 2008 Oct;28(10):1848-52.
Title:	[Changes in TGF-beta1/Smads signaling pathway in rats with chemical hepatocarcinogenesis].
Author:	Hua, Yun-peng\|Li, Shao-qiang\|Lai, Jia-ming\|Liang, Li-jian\|Peng, Bao-gang\|Liang, Hui-zhen\|Huang, Jie-fu
PMID:	18971187

21.
Journal:	J Clin Invest. 2009 Feb;119(2):349-61.
Title:	Human four-and-a-half LIM family members suppress tumor cell growth through a TGF-beta-like signaling pathway.
Author:	Ding, Lihua\|Wang, Zhaoyun\|Yan, Jinghua\|Yang, Xiao\|Liu, Aijun\|Qiu, Weiyi\|Zhu, Jianhua\|Han, Juqiang\|Zhang, Hao\|Lin, Jing\|Cheng, Long\|Qin, Xi\|Niu, Chang\|Yuan, Bin\|Wang, Xiaohui\|Zhu, Cui\|Zhou, Yan\|Li, Jiezhi\|Song, Haifeng\|Huang, Cuifen\|Ye, Qinong
PMID:	19139564

22.
Journal:	Zhonghua Zhong Liu Za Zhi. 2009 Sep;31(9):646-50.
Title:	[Epigallocatechin gallate induces apoptosis in human hepatocellular carcinoma HepG2 cells via TGF/Smad signaling pathway].
Author:	Tong, Jin-lu\|Nie, Fang\|Ran, Zhi-hua\|Pan, Chang-qing\|Xu, Xi-tao\|Zhu, Ming-ming\|Xiao, Shu-dong
PMID:	20021857

23.
Journal:	Cancer Res. 2009 Dec 1;69(23):8844-52.
Title:	Autophagy is activated by TGF-beta and potentiates TGF-beta-mediated growth inhibition in human hepatocellular carcinoma cells.
Author:	Kiyono, Kunihiko\|Suzuki, Hiroshi I\|Matsuyama, Hironori\|Morishita, Yasuyuki\|Komuro, Akiyoshi\|Kano, Mitsunobu R\|Sugimoto, Koichi\|Miyazono, Kohei
PMID:	19903843

24.
Journal:	Hepatol Res. 2009 May;39(5):501-9.
Title:	New mechanism of transforming growth factor-beta signaling in hepatoma: Dramatic up-regulation of tumor initiating cells and epidermal growth factor receptor expression.
Author:	Nishimura, Takeshi\|Azuma, Toshifumi\|Yokoyama, Akiko\|Ochiai, Hiromi\|Saito, Hidetsugu\|Hibi, Toshifumi
PMID:	19261001

25.
Journal:	Ann Surg Oncol. 2009 Nov;16(11):3176-82.
Title:	Strong Smad4 expression correlates with poor prognosis after surgery in patients with hepatocellular carcinoma.
Author:	Hiwatashi, Kiyokazu\|Ueno, Shinichi\|Sakoda, Masahiko\|Kubo, Fumitake\|Tateno, Taro\|Kurahara, Hiroshi\|Mataki, Yuko\|Maemura, Kosei\|Ishigami, Sumiya\|Shinchi, Hiroyuki\|Natsugoe, Shoji
PMID:	19626374

26.
Journal:	Oncogene. 2010 Mar 25;29(12):1787-97.
Title:	TGFbeta-mediated upregulation of hepatic miR-181b promotes hepatocarcinogenesis by targeting TIMP3.
Author:	Wang, B\|Hsu, S-H\|Majumder, S\|Kutay, H\|Huang, W\|Jacob, S T\|Ghoshal, K
PMID:	20023698

27.
Journal:	Zhonghua Gan Zang Bing Za Zhi. 2010 Feb;18(2):119-23.
Title:	[Effects of Smad4 on liver fibrosis and hepatocarcinogenesis in mice treated with CCl4/ethanol].
Author:	Xu, Xin-bao\|He, Zhen-ping\|Leng, Xi-sheng\|Liang, Zhi-qing\|Peng, Ji-run\|Zhang, Hong-yi\|Zhang, Hong-yi\|Xiao, Mei\|Zhang, Hui\|Liu, Cheng-li\|Zhang, Xi-dong
PMID:	20196951

28.
Journal:	Toxicol Appl Pharmacol. 2010 Aug 1;246(3):128-40.
Title:	Disruption of Smad-dependent signaling for growth of GST-P-positive lesions from the early stage in a rat two-stage hepatocarcinogenesis model.
Author:	Ichimura, Ryohei\|Mizukami, Sayaka\|Takahashi, Miwa\|Taniai, Eriko\|Kemmochi, Sayaka\|Mitsumori, Kunitoshi\|Shibutani, Makoto
PMID:	20423715

29.
Journal:	Mol Cell Biochem. 2010 Oct;343(1-2):155-62.
Title:	Expression of Oct4 in HCC and modulation to wnt/beta-catenin and TGF-beta signal pathways.
Author:	Yuan, FangJun\|Zhou, Wenbo\|Zou, Can\|Zhang, Zhiyun\|Hu, Hongsheng\|Dai, Zongqing\|Zhang, YouShun
PMID:	20549546

30.
Journal:	Mol Med Rep. 2010 Mar-Apr;3(2):295-9.
Title:	Lentiviral-mediated Smad4 RNAi promotes SMMC-7721 cell migration by regulation of MMP-2, VEGF and MAPK signaling.
Author:	Huang, Xiaodan\|Huang, Shu\|Zhang, Faming\|Han, Xiang\|Miao, Lin\|Liu, Zheng\|Fan, Zhining\|Ji, Guozhong
PMID:	21472236

31.
Journal:	Proteomics. 2011 Aug;11(16):3390-401.
Title:	Quantitative phosphoproteomics of transforming growth factor-beta signaling in colon cancer cells.
Author:	Ali, Naveid A\|Molloy, Mark P
PMID:	21751366

32.
Journal:	Biochem Biophys Res Commun. 2011 Nov 4;414(4):675-80.
Title:	miR-146a suppresses the sensitivity to interferon-alpha in hepatocellular carcinoma cells.
Author:	Tomokuni, Akira\|Eguchi, Hidetoshi\|Tomimaru, Yoshito\|Wada, Hiroshi\|Kawamoto, Koichi\|Kobayashi, Shogo\|Marubashi, Shigeru\|Tanemura, Masahiro\|Nagano, Hiroaki\|Mori, Masaki\|Doki, Yuichiro
PMID:	21982769

33.
Journal:	Mol Cancer Res. 2012 Mar;10(3):415-27.
Title:	The activation of MEK/ERK signaling pathway by bone morphogenetic protein 4 to increase hepatocellular carcinoma cell proliferation and migration.
Author:	Chiu, Chiang-Yen\|Kuo, Kung-Kai\|Kuo, Tzu-Lei\|Lee, King-The\|Cheng, Kuang-Hung
PMID:	22241220

34.
Journal:	Clin Transl Gastroenterol. 2012 Oct 4;3:e23.
Title:	Analysis of Notch and TGF-beta Signaling Expression in Different Stages of Disease Progression During Hepatitis B Virus Infection.
Author:	Trehanpati, Nirupama\|Shrivastav, Shikha\|Shivakumar, Bhavana\|Khosla, Ritu\|Bhardwaj, Suvercha\|Chaturvedi, Jaya\|Sukriti\|Kumar, Binayak\|Bose, Sujoy\|Mani Tripathi, Dinesh\|Das, Trinath\|Sakhuja, Puja\|Rastogi, Archana\|Bhihari, Chagan\|Singh, Shivender\|Gupta, Subha
PMID:	23238065

35.
Journal:	Indian J Pharmacol. 2012 Sep-Oct;44(5):599-601.
Title:	Nimesulide inhibits the proliferation of HepG2 by up-regulation of Smad4.
Author:	Yang, Shaoqi\|Guo, Ruifang\|Huang, Liya\|Yang, Li\|Jiang, Dong
PMID:	23112421

36.
Journal:	Asian Pac J Cancer Prev. 2012;13(4):1297-303.
Title:	Smad4 expression in hepatocellular carcinoma differs by hepatitis status.
Author:	Yao, Lei\|Li, Fu-Jun\|Tang, Zhi-Qiang\|Gao, Shuang\|Wu, Qe-Quan
PMID:	22799322

37.
Journal:	World J Gastroenterol. 2012 May 7;18(17):2035-42.
Title:	Transactivation of the TIEG1 confers growth inhibition of transforming growth factor-beta-susceptible hepatocellular carcinoma cells.
Author:	Jiang, Lei\|Lai, Yiu-Kay\|Zhang, Jin-Fang\|Chan, Chu-Yan\|Lu, Gang\|Lin, Marie Cm\|He, Ming-Liang\|Li, Ji-Cheng\|Kung, Hsiang-Fu
PMID:	22563190

38.
Journal:	Hepatobiliary Pancreat Dis Int. 2012 Feb;11(1):51-9.
Title:	Smad3 and its phosphoisoforms are prognostic predictors of hepatocellular carcinoma after curative hepatectomy.
Author:	Kim, Seok-Hyung\|Ahn, Soomin\|Park, Cheol-Keun
PMID:	22251470

39.
Journal:	Cancer Biol Ther. 2013 Nov;14(11):1059-67.
Title:	Targeting the ERK pathway reduces liver metastasis of Smad4-inactivated colorectal cancer.
Author:	Ai, Xi\|Wu, Yanhui\|Zhang, Wei\|Zhang, Zhanguo\|Jin, Guannan\|Zhao, Jianping\|Yu, Jingjing\|Lin, Youzhi\|Zhang, Wanguang\|Liang, Huifang\|Datta, Pran K\|Zhang, Mingzhi\|Zhang, Bixiang\|Chen, Xiaoping
PMID:	24025354

40.
Journal:	APMIS. 2013 Oct;121(10):967-75.
Title:	Relationship of TGF-beta1 and Smad7 expression with decreased dendritic cell infiltration in liver gastrointestinal cancer metastasis.
Author:	Gulubova, Maya\|Manolova, Irena\|Ananiev, Julian\|Kjurkchiev, Dobroslav\|Julianov, Alexander\|Altunkova, Iskra
PMID:	23998914

41.
Journal:	PLoS One. 2013 Jul 29;8(7):e68744.
Title:	MicroRNA-224 targets SMAD family member 4 to promote cell proliferation and negatively influence patient survival.
Author:	Wang, Yu\|Ren, Jianwei\|Gao, Yun\|Ma, Joel Z I\|Toh, Han Chong\|Chow, Pierce\|Chung, Alexander Y F\|Ooi, London L P J\|Lee, Caroline G L
PMID:	23922662

42.
Journal:	PLoS One. 2013 May 21;8(5):e63436.
Title:	TGF-beta signaling is often attenuated during hepatotumorigenesis, but is retained for the malignancy of hepatocellular carcinoma cells.
Author:	Mu, Xiaoxin\|Lin, Shu\|Yang, Junhua\|Chen, Chen\|Chen, Yun\|Herzig, Maryanne C\|Washburn, Kenneth\|Halff, Glenn A\|Walter, Christi A\|Sun, Beicheng\|Sun, Lu-Zhe
PMID:	23704908

43.
Journal:	Gastroenterology. 2013 May;144(5):1042-1054.e4.
Title:	Transforming growth factor-beta signaling in hepatocytes promotes hepatic fibrosis and carcinogenesis in mice with hepatocyte-specific deletion of TAK1.
Author:	Yang, Ling\|Inokuchi, Sayaka\|Roh, Yoon Seok\|Song, Jingyi\|Loomba, Rohit\|Park, Eek Joong\|Seki, Ekihiro
PMID:	23391818

44.
Journal:	DNA Cell Biol. 2013 Sep;32(9):531-40.
Title:	L1-ORF1p, a Smad4 interaction protein, promotes proliferation of HepG2 cells and tumorigenesis in mice.
Author:	Zhu, Yunfeng\|Feng, Fan\|Yu, Jiyun\|Song, Bin\|Hu, Mingming\|Gao, Xudong\|Wang, Yue\|Zhang, Qing
PMID:	23863096

45.
Journal:	Autophagy. 2014 Sep;10(9):1687-9.
Title:	Autophagy-preferential degradation of MIR224 participates in hepatocellular carcinoma tumorigenesis.
Author:	Lan, Sheng-Hui\|Wu, Shan-Ying\|Zuchini, Roberto\|Lin, Xi-Zhang\|Su, Ih-Jen\|Tsai, Ting-Fen\|Lin, Yen-Ju\|Wu, Cheng-Tao\|Liu, Hsiao-Sheng
PMID:	25068270

46.
Journal:	PLoS One. 2014 Aug 15;9(8):e104979.
Title:	Reporting tumor molecular heterogeneity in histopathological diagnosis.
Author:	Mafficini, Andrea\|Amato, Eliana\|Fassan, Matteo\|Simbolo, Michele\|Antonello, Davide\|Vicentini, Caterina\|Scardoni, Maria\|Bersani, Samantha\|Gottardi, Marisa\|Rusev, Borislav\|Malpeli, Giorgio\|Corbo, Vincenzo\|Barbi, Stefano\|Sikora, Katarzyna O\|Lawlor, Rita T\|Tor
PMID:	25127237

47.
Journal:	Hepatology. 2014 Nov;60(5):1645-58.
Title:	Lysyl oxidase-like 2 is critical to tumor microenvironment and metastatic niche formation in hepatocellular carcinoma.
Author:	Wong, Carmen Chak-Lui\|Tse, Aki Pui-Wah\|Huang, Yan-Ping\|Zhu, Yan-Ting\|Chiu, David Kung-Chun\|Lai, Robin Kit-Ho\|Au, Sandy Leung-Kuen\|Kai, Alan Ka-Lun\|Lee, Joyce Man-Fong\|Wei, Larry Lai\|Tsang, Felice Ho-Ching\|Lo, Regina Cheuk-Lam\|Shi, Jue\|Zheng, Yong-Ping\|Won
PMID:	25048396

48.
Journal:	Oncol Rep. 2014 Sep;32(3):1124-32.
Title:	S-allylmercaptocysteine promotes MAPK inhibitor-induced apoptosis by activating the TGF-beta signaling pathway in cancer cells.
Author:	Tong, Dandan\|Qu, Hui\|Meng, Xiangning\|Jiang, Yang\|Liu, Duanyang\|Ye, Shengqian\|Chen, He\|Jin, Yan\|Fu, Songbin\|Geng, Jingshu
PMID:	24970681

49.
Journal:	Hepatology. 2014 Nov;60(5):1620-36.
Title:	Reduced expression of transcriptional intermediary factor 1 gamma promotes metastasis and indicates poor prognosis of hepatocellular carcinoma.
Author:	Ding, Ze-yang\|Jin, Guan-nan\|Wang, Wei\|Chen, Wei-xun\|Wu, Yan-hui\|Ai, Xi\|Chen, Lin\|Zhang, Wan-guang\|Liang, Hui-fang\|Laurence, Arian\|Zhang, Ming-zhi\|Datta, Pran K\|Zhang, Bixiang\|Chen, Xiao-ping
PMID:	24954480

50.
Journal:	BMC Cancer. 2014 Jun 2;14:393.
Title:	MicroRNA-26b inhibits epithelial-mesenchymal transition in hepatocellular carcinoma by targeting USP9X.
Author:	Shen, Gang\|Lin, Ye\|Yang, Xuewei\|Zhang, Jing\|Xu, Zhe\|Jia, Hongyun
PMID:	24890815

51.
Journal:	J Hepatobiliary Pancreat Sci. 2014 Jun;21(6):380-7.
Title:	Genomic and transcriptional alterations of cholangiocarcinoma.
Author:	Ito, Takeshi\|Sakurai-Yageta, Mika\|Goto, Akiteru\|Pairojkul, Chawalit\|Yongvanit, Puangrat\|Murakami, Yoshinori
PMID:	24532422

52.
Journal:	Oncol Rep. 2014 Feb;31(2):885-93.
Title:	Enhancement of DEN-induced liver tumourigenesis in hepatocyte-specific Lass2-knockout mice coincident with upregulation of the TGF-beta1-Smad4-PAI-1 axis.
Author:	Chen, Lufang\|Lu, Xiaodong\|Zeng, Tiantian\|Chen, Yuanyuan\|Chen, Qian\|Wu, Weijiang\|Yan, Xun\|Cai, Honghua\|Zhang, Zhijian\|Shao, Qixiang\|Qin, Wenxin
PMID:	24337404

53.
Journal:	J Gastroenterol Hepatol. 2014 Jun;29(6):1284-91.
Title:	Compound Astragalus and Salvia miltiorrhiza extracts suppress hepatocarcinogenesis by modulating transforming growth factor-beta/Smad signaling.
Author:	Hu, Xiangpeng\|Rui, Wenjuan\|Wu, Chao\|He, Shufang\|Jiang, Jiemei\|Zhang, Xiaoxiang\|Yang, Yan
PMID:	24329763

54.
Journal:	Hepatology. 2014 Feb;59(2):505-17.
Title:	Autophagy suppresses tumorigenesis of hepatitis B virus-associated hepatocellular carcinoma through degradation of microRNA-224.
Author:	Lan, Sheng-Hui\|Wu, Shan-Ying\|Zuchini, Roberto\|Lin, Xi-Zhang\|Su, Ih-Jen\|Tsai, Ting-Fen\|Lin, Yen-Ju\|Wu, Cheng-Tao\|Liu, Hsiao-Sheng
PMID:	23913306

55.
Journal:	Oncogene. 2015 Sep 24;34(39):5055-68.
Title:	SMAD4 exerts a tumor-promoting role in hepatocellular carcinoma.
Author:	Hernanda, P Y\|Chen, K\|Das, A M\|Sideras, K\|Wang, W\|Li, J\|Cao, W\|Bots, S J A\|Kodach, L L\|de Man, R A\|Ijzermans, J N M\|Janssen, H L A\|Stubbs, A P\|Sprengers, D\|Bruno, M J\|Metselaar, H J\|ten Hagen, T L M\|Kwekkeboom, J\|Peppelenbosch, M P\|Pan, Q
PMID:	25531314

56.
Journal:	BMC Cancer. 2015 Mar 11;15:116.
Title:	The prognostic value of combined TGF-beta1 and ELF in hepatocellular carcinoma.
Author:	Ji, Fei\|Fu, Shun-Jun\|Shen, Shun-Li\|Zhang, Long-Juan\|Cao, Qing-Hua\|Li, Shao-Qiang\|Peng, Bao-Gang\|Liang, Li-Jian\|Hua, Yun-Peng
PMID:	25880619

57.
Journal:	J Ethnopharmacol. 2015 Jul 1;169:219-28.
Title:	Compound Astragalus and Salvia miltiorrhiza extracts modulate MAPK-regulated TGF-beta/Smad signaling in hepatocellular carcinoma by multi-target mechanism.
Author:	Boye, Alex\|Wu, Chao\|Jiang, Yufeng\|Wang, Jiyu\|Wu, Jiajun\|Yang, Xiaochuan\|Yang, Yan
PMID:	25934513

58.
Journal:	Biochem Biophys Res Commun. 2015 Oct 30;466(4):676-81.
Title:	Hepatitis B virus X promotes hepatocellular carcinoma development via nuclear protein 1 pathway.
Author:	Bak, Yesol\|Shin, Hye-jun\|Bak, In seon\|Yoon, Do-young\|Yu, Dae-Yeul
PMID:	26392315

59.
Journal:	Gastroenterol Hepatol Bed Bench. 2015 Fall;8(4):262-9.
Title:	Blocking of SMAD4 expression by shRNA effectively inhibits fibrogenesis of human hepatic stellate cells.
Author:	Khanizadeh, Sayyad\|Ravanshad, Mehrdad\|Hosseini, SeyedYounes\|Davoodian, Parivash\|Nejati Zadeh, Azim\|Sarvari, Jamal
PMID:	26468346

60.
Journal:	Mol Med Rep. 2016 Feb;13(2):1345-52.
Title:	c-Jun N-terminal kinase inhibitor favors transforming growth factor-beta to antagonize hepatitis B virus X protein-induced cell growth promotion in hepatocellular carcinoma.
Author:	Wu, Yan-Hui\|Ai, Xi\|Liu, Fu-Yao\|Liang, Hui-Fang\|Zhang, Bi-Xiang\|Chen, Xiao-Ping
PMID:	26648552

61.
Journal:	Eur J Cell Biol. 2016 Nov;95(11):503-512.
Title:	TGF-beta1 promotes linear invadosome formation in hepatocellular carcinoma cells, through DDR1 up-regulation and collagen I cross-linking.
Author:	Ezzoukhry, Zakaria\|Henriet, Elodie\|Piquet, Leo\|Boye, Kevin\|Bioulac-Sage, Paulette\|Balabaud, Charles\|Couchy, Gabrielle\|Zucman-Rossi, Jessica\|Moreau, Violaine\|Saltel, Frederic
PMID:	27720259

62.
Journal:	Oncotarget. 2016 Nov 8;7(45):72908-72922.
Title:	Genomic characterization of liver metastases from colorectal cancer patients.
Author:	Sayagues, Jose Maria\|Corchete, Luis Antonio\|Gutierrez, Maria Laura\|Sarasquete, Maria Eugenia\|Del Mar Abad, Maria\|Bengoechea, Oscar\|Ferminan, Encarna\|Anduaga, Maria Fernanda\|Del Carmen, Sofia\|Iglesias, Manuel\|Esteban, Carmen\|Angoso, Maria\|Alcazar, Jose Ant
PMID:	27662660

63.
Journal:	Onco Targets Ther. 2016 Jul 29;9:4705-14.
Title:	MiR-144 suppresses cell proliferation, migration, and invasion in hepatocellular carcinoma by targeting SMAD4.
Author:	Yu, Min\|Lin, Ye\|Zhou, Yu\|Jin, Haosheng\|Hou, Baohua\|Wu, Zhongshi\|Li, Zhide\|Jian, Zhixiang\|Sun, Jian
PMID:	27536132

64.
Journal:	Oncotarget. 2016 Apr 26;7(17):23825-36.
Title:	Two classes of intrahepatic cholangiocarcinoma defined by relative abundance of mutations and copy number alterations.
Author:	Kim, Young-Ho\|Hong, Eun-Kyung\|Kong, Sun-Young\|Han, Sung-Sik\|Kim, Seoung-Hoon\|Rhee, Je-Keun\|Hwang, Soo-Kyung\|Park, Sang-Jae\|Kim, Tae-Min
PMID:	27009864

65.
Journal:	Cell Oncol (Dordr). 2016 Apr;39(2):119-28.
Title:	Down-regulation of osteopontin mediates a novel mechanism underlying the cytostatic activity of TGF-beta.
Author:	Zhang, Jing\|Yamada, Osamu\|Kida, Shinya\|Matsushita, Yoshihisa\|Hattori, Toshio
PMID:	26584547

66.
Journal:	Tumour Biol. 2016 Mar;37(3):3675-81.
Title:	TGF-beta1 pathway affects the protein expression of many signaling pathways, markers of liver cancer stem cells, cytokeratins, and TERT in liver cancer HepG2 cells.
Author:	Wang, Xin-Hong\|Liu, Ming-Na\|Sun, Xun\|Xu, Chun-Huan\|Liu, Jing\|Chen, Jing\|Xu, Rui-Ling\|Li, Bao-Xin
PMID:	26462837

67.
Journal:	Tumour Biol. 2016 Mar;37(3):3405-15.
Title:	HBx interacted with Smad4 to deprive activin a growth inhibition function in hepatocyte HL7702 on CRM1 manner.
Author:	Shi, Ying\|Zhang, Haipeng\|Han, Zhu\|Mi, Xuguang\|Zhang, Wenyan\|Lv, Mingyu
PMID:	26449823

68.
Journal:	J Exp Clin Cancer Res. 2016 Jan 27;35:19.
Title:	MiR-130a-3p regulates cell migration and invasion via inhibition of Smad4 in gemcitabine resistant hepatoma cells.
Author:	Liu, Yang\|Li, Yumei\|Wang, Rui\|Qin, Shukui\|Liu, Jing\|Su, Fang\|Yang, Yan\|Zhao, Fuyou\|Wang, Zishu\|Wu, Qiong
PMID:	26817584

69.
Journal:	Oncotarget. 2017 Jun 13;8(24):38811-38824.
Title:	Smad inhibitor induces CSC differentiation for effective chemosensitization in cyclin D1- and TGF-beta/Smad-regulated liver cancer stem cell-like cells.
Author:	Xia, Wei\|Lo, Chung Mau\|Poon, Randy Y C\|Cheung, Tan To\|Chan, Albert C Y\|Chen, Lin\|Yang, Sitian\|Tsao, George S W\|Wang, Xiao Qi
PMID:	28415588

70.
Journal:	Oncotarget. 2017 Apr 11;8(15):24728-24740.
Title:	USP22 knockdown enhanced chemosensitivity of hepatocellular carcinoma cells to 5-Fu by up-regulation of Smad4 and suppression of Akt.
Author:	Zhang, Jing\|Luo, Nan\|Tian, Yu\|Li, Jiazhi\|Yang, Xiaozhou\|Yin, Huimin\|Xiao, Congshu\|Sheng, Jie\|Li, Yang\|Tang, Bo\|Li, Rongkuan
PMID:	28445968

71.
Journal:	Gastroenterology. 2017 Nov;153(5):1378-1391.e6.
Title:	Transforming Growth Factor-beta Promotes Liver Tumorigenesis in Mice via Up-regulation of Snail.
Author:	Moon, Hyuk\|Ju, Hye-Lim\|Chung, Sook In\|Cho, Kyung Joo\|Eun, Jung Woo\|Nam, Suk Woo\|Han, Kwang-Hyub\|Calvisi, Diego F\|Ro, Simon Weonsang
PMID:	28734833

72.
Journal:	Bratisl Lek Listy. 2017;118(2):85-88.
Title:	Cisplatin plus norcantharidin alter the expression of TGF-beta1/Smads signaling pathway in hepatocellular carcinoma.
Author:	Li, K Y\|Shi, C X\|Huang, J Z\|Tang, K L
PMID:	28814088

73.
Journal:	Cell Biol Int. 2018 Sep;42(10):1370-1376.
Title:	MicroRNA-34a-5p inhibits liver fibrosis by regulating TGF-beta1/Smad3 pathway in hepatic stellate cells.
Author:	Feili, Xiao\|Wu, Shuang\|Ye, Weiwei\|Tu, Juncai\|Lou, Lianqing
PMID:	29957876

74.
Journal:	APMIS. 2018 Jun;126(6):477-485.
Title:	Significance of pSmad2/3 and Smad4 in hepatitis C virus-related liver fibrosis and hepatocellular carcinoma.
Author:	Moussa, Mona Mohammed\|Helal, Noha Said\|Youssef, Mohieldin Magdy
PMID:	29924446

75.
Journal:	Mol Ther Nucleic Acids. 2018 Jun 1;11:243-252.
Title:	Hepatocellular Carcinoma Cell-Secreted Exosomal MicroRNA-210 Promotes Angiogenesis In Vitro and In Vivo.
Author:	Lin, Xue-Jia\|Fang, Jian-Hong\|Yang, Xiao-Jing\|Zhang, Chong\|Yuan, Yunfei\|Zheng, Limin\|Zhuang, Shi-Mei
PMID:	29858059

76.
Journal:	Cancer Biol Ther. 2018 May 25:1-28.
Title:	The prognostic correlation between CD105 expression level in tumor tissue and peripheral blood and sunitinib administration in advanced hepatocellular carcinoma.
Author:	Yang, Yi\|Guan, Qiaobin\|Guo, Li\|Han, Chenyang
PMID:	29799303

77.
Journal:	BMC Cancer. 2018 Apr 24;18(1):460.
Title:	Low expression of c-Myc protein predicts poor outcomes in patients with hepatocellular carcinoma after resection.
Author:	Ji, Fei\|Zhang, Zhi-Heng\|Zhang, Yi\|Shen, Shun-Li\|Cao, Qing-Hua\|Zhang, Long-Juan\|Li, Shao-Qiang\|Peng, Bao-Gang\|Liang, Li-Jian\|Hua, Yun-Peng
PMID:	29690860

78.
Journal:	Cancer Sci. 2018 May;109(5):1282-1291.
Title:	Molecular genomic landscapes of hepatobiliary cancer.
Author:	Shibata, Tatsuhiro\|Arai, Yasuhito\|Totoki, Yasushi
PMID:	29573058

79.
Journal:	Cell Death Discov. 2018 Mar 12;4:42.
Title:	Regulation of transforming growth factor is involved in the efficacy of combined 5-fluorouracil and interferon alpha-2b therapy of advanced hepatocellular carcinoma.
Author:	Okada, Youhei\|Wang, Ting\|Kasai, Kazuhiro\|Suzuki, Kazuyuki\|Takikawa, Yasuhiro
PMID:	29560281

80.
Journal:	Oncol Lett. 2018 Apr;15(4):4867-4872.
Title:	Mitogen-activated protein kinase inhibitors reduce the nuclear accumulation of phosphorylated Smads by inhibiting Imp 7 or Imp 8 in HepG2 cells.
Author:	Hu, Xiangpeng\|Kan, Hongwei\|Boye, Alex\|Jiang, Yufeng\|Wu, Chao\|Yang, Yan
PMID:	29552126

81.
Journal:	Biochem Biophys Res Commun. 2018 Apr 6;498(3):609-615.
Title:	Heme oxygenase-1/carbon monoxide axis suppresses transforming growth factor-beta1-induced growth inhibition by increasing ERK1/2-mediated phosphorylation of Smad3 at Thr-179 in human hepatocellular carcinoma cell lines.
Author:	Park, Seong Ji\|Lee, Seung Koo\|Lim, Chae Rin\|Park, Hye Won\|Liu, Fang\|Kim, Seong-Jin\|Kim, Byung-Chul
PMID:	29524413

82.
Journal:	Cell Death Dis. 2018 Feb 27;9(3):324.
Title:	AGO1 may influence the prognosis of hepatocellular carcinoma through TGF-beta pathway.
Author:	Wang, Miao\|Zhang, Lyu\|Liu, Zeyang\|Zhou, Jiamin\|Pan, Qi\|Fan, Jia\|Zang, Rongyu\|Wang, Lu
PMID:	29487329

83.
Journal:	Sci Rep. 2018 Feb 12;8(1):2808.
Title:	Nemopilema nomurai jellyfish venom exerts an anti-metastatic effect by inhibiting Smad- and NF-kappaB-mediated epithelial-mesenchymal transition in HepG2 cells.
Author:	Lee, Hyunkyoung\|Pyo, Min Jung\|Bae, Seong Kyeong\|Heo, Yunwi\|Choudhary, Indu\|Hwang, Duhyeon\|Yang, Hyeryeon\|Kim, Je-Hein\|Chae, Jinho\|Han, Chang Hoon\|Kang, Changkeun\|Yum, Seungshic\|Kim, Euikyung
PMID:	29434219

84.
Journal:	J Cell Mol Med. 2018 Jan;22(1):439-451.
Title:	Disulfiram combined with copper inhibits metastasis and epithelial-mesenchymal transition in hepatocellular carcinoma through the NF-kappaB and TGF-beta pathways.
Author:	Li, Yi\|Wang, Li-Hui\|Zhang, Hao-Tian\|Wang, Ya-Ting\|Liu, Shuai\|Zhou, Wen-Long\|Yuan, Xiang-Zhong\|Li, Tian-Yang\|Wu, Chun-Fu\|Yang, Jing-Yu
PMID:	29148232