Primary Site >> Liver Cancer
Gene >> SMAD4
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Ref: Mutation analysis of transforming growth factor beta type II receptor, Smad2, and Smad4 in hepatocellular carcinoma. PMID: 9863018 Ref: Smad2 and Smad4 gene mutations in hepatocellular carcinoma. PMID: 10490821 |
Ref: The hepatitis B virus encoded oncoprotein pX amplifies TGF-beta family signaling through direct interaction with Smad4: potential mechanism of hepatitis B virus-induced liver fibrosis. PMID: 11230153 |
Ref: Smad4 overexpression in hepatocellular carcinoma is strongly associated with transforming growth factor beta II receptor immunolabeling. PMID: 12378510 |
Ref: Distortion of autocrine transforming growth factor beta signal accelerates malignant potential by enhancing cell growth as well as PAI-1 and VEGF production in human hepatocellular carcinoma cells. PMID: 12700666 |
Ref: Expression of Smad7 in hepatocellular carcinoma and dysplastic nodules: resistance mechanism to transforming growth factor-beta. PMID: 15086168 Ref: Factors of transforming growth factor beta signalling are co-regulated in human hepatocellular carcinoma. PMID: 15455231 Ref: Regulation of fibronectin by thyroid hormone receptors. PMID: 15525600 |
Ref: [The study of inhibition effect of octreotide on the growth of hepatocellular carcinoma xenografts in situ in nude mice]. PMID: 16008961 Ref: [Expression of Smad4 and transforming growth factor-beta1, transforming growth factor-beta receptor II in cholangiocarcinoma tissue and its biological significance]. PMID: 16083599 |
Ref: Modulation of the transforming growth factor-beta signal transduction pathway by hepatitis C virus nonstructural 5A protein. PMID: 16407286 Ref: Role of transforming growth factor-beta1-smad signal transduction pathway in patients with hepatocellular carcinoma. PMID: 16489684 Ref: TGF-beta1/SMAD signaling pathway mediates p53-dependent apoptosis in hepatoma cell lines. PMID: 16615282 Ref: Apoptosis of human hepatoma cell lines induced by transforming growth factor beta 1 (TGF-beta1) correlates with p53 and Smad4 activation. PMID: 16617361 |
Ref: Disruption of transforming growth factor-beta signaling through beta-spectrin ELF leads to hepatocellular cancer through cyclin D1 activation. PMID: 17546056 |
Ref: Expression of transforming growth factors in hepatocellular carcinoma and its relations with clinicopathological parameters and prognosis. PMID: 18397854 Ref: Upregulation of miR-23a approximately 27a approximately 24 decreases transforming growth factor-beta-induced tumor-suppressive activities in human hepatocellular carcinoma cells. PMID: 18508316 Ref: Transforming growth factor-beta-mediated tumor necrosis factor-related apoptosis-inducing ligand expression and apoptosis in hepatoma cells requires functional cooperation between Smad proteins and activator protein-1. PMID: 18644981 Ref: Lentiviral-mediated Smad4 RNAi induced anti-proliferation by p16 up-regulation and apoptosis by caspase 3 down-regulation in hepatoma SMMC-7721 cells. PMID: 18949401 Ref: [Changes in TGF-beta1/Smads signaling pathway in rats with chemical hepatocarcinogenesis]. PMID: 18971187 |
Ref: Human four-and-a-half LIM family members suppress tumor cell growth through a TGF-beta-like signaling pathway. PMID: 19139564 Ref: New mechanism of transforming growth factor-beta signaling in hepatoma: Dramatic up-regulation of tumor initiating cells and epidermal growth factor receptor expression. PMID: 19261001 Ref: Strong Smad4 expression correlates with poor prognosis after surgery in patients with hepatocellular carcinoma. PMID: 19626374 Ref: Autophagy is activated by TGF-beta and potentiates TGF-beta-mediated growth inhibition in human hepatocellular carcinoma cells. PMID: 19903843 Ref: [Epigallocatechin gallate induces apoptosis in human hepatocellular carcinoma HepG2 cells via TGF/Smad signaling pathway]. PMID: 20021857 |
Ref: TGFbeta-mediated upregulation of hepatic miR-181b promotes hepatocarcinogenesis by targeting TIMP3. PMID: 20023698 Ref: [Effects of Smad4 on liver fibrosis and hepatocarcinogenesis in mice treated with CCl4/ethanol]. PMID: 20196951 Ref: Disruption of Smad-dependent signaling for growth of GST-P-positive lesions from the early stage in a rat two-stage hepatocarcinogenesis model. PMID: 20423715 Ref: Expression of Oct4 in HCC and modulation to wnt/beta-catenin and TGF-beta signal pathways. PMID: 20549546 Ref: Lentiviral-mediated Smad4 RNAi promotes SMMC-7721 cell migration by regulation of MMP-2, VEGF and MAPK signaling. PMID: 21472236 |
Ref: Quantitative phosphoproteomics of transforming growth factor-beta signaling in colon cancer cells. PMID: 21751366 Ref: miR-146a suppresses the sensitivity to interferon-alpha in hepatocellular carcinoma cells. PMID: 21982769 |
Ref: The activation of MEK/ERK signaling pathway by bone morphogenetic protein 4 to increase hepatocellular carcinoma cell proliferation and migration. PMID: 22241220 Ref: Smad3 and its phosphoisoforms are prognostic predictors of hepatocellular carcinoma after curative hepatectomy. PMID: 22251470 Ref: Transactivation of the TIEG1 confers growth inhibition of transforming growth factor-beta-susceptible hepatocellular carcinoma cells. PMID: 22563190 Ref: Smad4 expression in hepatocellular carcinoma differs by hepatitis status. PMID: 22799322 Ref: Nimesulide inhibits the proliferation of HepG2 by up-regulation of Smad4. PMID: 23112421 Ref: Analysis of Notch and TGF-beta Signaling Expression in Different Stages of Disease Progression During Hepatitis B Virus Infection. PMID: 23238065 |
Ref: Transforming growth factor-beta signaling in hepatocytes promotes hepatic fibrosis and carcinogenesis in mice with hepatocyte-specific deletion of TAK1. PMID: 23391818 Ref: TGF-beta signaling is often attenuated during hepatotumorigenesis, but is retained for the malignancy of hepatocellular carcinoma cells. PMID: 23704908 Ref: L1-ORF1p, a Smad4 interaction protein, promotes proliferation of HepG2 cells and tumorigenesis in mice. PMID: 23863096 Ref: MicroRNA-224 targets SMAD family member 4 to promote cell proliferation and negatively influence patient survival. PMID: 23922662 Ref: Relationship of TGF-beta1 and Smad7 expression with decreased dendritic cell infiltration in liver gastrointestinal cancer metastasis. PMID: 23998914 Ref: Targeting the ERK pathway reduces liver metastasis of Smad4-inactivated colorectal cancer. PMID: 24025354 |
Ref: Autophagy suppresses tumorigenesis of hepatitis B virus-associated hepatocellular carcinoma through degradation of microRNA-224. PMID: 23913306 Ref: Compound Astragalus and Salvia miltiorrhiza extracts suppress hepatocarcinogenesis by modulating transforming growth factor-beta/Smad signaling. PMID: 24329763 Ref: Enhancement of DEN-induced liver tumourigenesis in hepatocyte-specific Lass2-knockout mice coincident with upregulation of the TGF-beta1-Smad4-PAI-1 axis. PMID: 24337404 Ref: Genomic and transcriptional alterations of cholangiocarcinoma. PMID: 24532422 Ref: MicroRNA-26b inhibits epithelial-mesenchymal transition in hepatocellular carcinoma by targeting USP9X. PMID: 24890815 Ref: Reduced expression of transcriptional intermediary factor 1 gamma promotes metastasis and indicates poor prognosis of hepatocellular carcinoma. PMID: 24954480 Ref: S-allylmercaptocysteine promotes MAPK inhibitor-induced apoptosis by activating the TGF-beta signaling pathway in cancer cells. PMID: 24970681 Ref: Lysyl oxidase-like 2 is critical to tumor microenvironment and metastatic niche formation in hepatocellular carcinoma. PMID: 25048396 Ref: Autophagy-preferential degradation of MIR224 participates in hepatocellular carcinoma tumorigenesis. PMID: 25068270 Ref: Reporting tumor molecular heterogeneity in histopathological diagnosis. PMID: 25127237 |
Ref: SMAD4 exerts a tumor-promoting role in hepatocellular carcinoma. PMID: 25531314 Ref: The prognostic value of combined TGF-beta1 and ELF in hepatocellular carcinoma. PMID: 25880619 Ref: Compound Astragalus and Salvia miltiorrhiza extracts modulate MAPK-regulated TGF-beta/Smad signaling in hepatocellular carcinoma by multi-target mechanism. PMID: 25934513 Ref: Hepatitis B virus X promotes hepatocellular carcinoma development via nuclear protein 1 pathway. PMID: 26392315 Ref: Blocking of SMAD4 expression by shRNA effectively inhibits fibrogenesis of human hepatic stellate cells. PMID: 26468346 |
Ref: HBx interacted with Smad4 to deprive activin a growth inhibition function in hepatocyte HL7702 on CRM1 manner. PMID: 26449823 Ref: TGF-beta1 pathway affects the protein expression of many signaling pathways, markers of liver cancer stem cells, cytokeratins, and TERT in liver cancer HepG2 cells. PMID: 26462837 Ref: Down-regulation of osteopontin mediates a novel mechanism underlying the cytostatic activity of TGF-beta. PMID: 26584547 Ref: c-Jun N-terminal kinase inhibitor favors transforming growth factor-beta to antagonize hepatitis B virus X protein-induced cell growth promotion in hepatocellular carcinoma. PMID: 26648552 Ref: MiR-130a-3p regulates cell migration and invasion via inhibition of Smad4 in gemcitabine resistant hepatoma cells. PMID: 26817584 Ref: Two classes of intrahepatic cholangiocarcinoma defined by relative abundance of mutations and copy number alterations. PMID: 27009864 Ref: MiR-144 suppresses cell proliferation, migration, and invasion in hepatocellular carcinoma by targeting SMAD4. PMID: 27536132 Ref: Genomic characterization of liver metastases from colorectal cancer patients. PMID: 27662660 Ref: TGF-beta1 promotes linear invadosome formation in hepatocellular carcinoma cells, through DDR1 up-regulation and collagen I cross-linking. PMID: 27720259 |
Ref: Smad inhibitor induces CSC differentiation for effective chemosensitization in cyclin D1- and TGF-beta/Smad-regulated liver cancer stem cell-like cells. PMID: 28415588 Ref: USP22 knockdown enhanced chemosensitivity of hepatocellular carcinoma cells to 5-Fu by up-regulation of Smad4 and suppression of Akt. PMID: 28445968 Ref: Transforming Growth Factor-beta Promotes Liver Tumorigenesis in Mice via Up-regulation of Snail. PMID: 28734833 Ref: Cisplatin plus norcantharidin alter the expression of TGF-beta1/Smads signaling pathway in hepatocellular carcinoma. PMID: 28814088 |
Ref: Disulfiram combined with copper inhibits metastasis and epithelial-mesenchymal transition in hepatocellular carcinoma through the NF-kappaB and TGF-beta pathways. PMID: 29148232 Ref: Nemopilema nomurai jellyfish venom exerts an anti-metastatic effect by inhibiting Smad- and NF-kappaB-mediated epithelial-mesenchymal transition in HepG2 cells. PMID: 29434219 Ref: AGO1 may influence the prognosis of hepatocellular carcinoma through TGF-beta pathway. PMID: 29487329 Ref: Heme oxygenase-1/carbon monoxide axis suppresses transforming growth factor-beta1-induced growth inhibition by increasing ERK1/2-mediated phosphorylation of Smad3 at Thr-179 in human hepatocellular carcinoma cell lines. PMID: 29524413 Ref: Mitogen-activated protein kinase inhibitors reduce the nuclear accumulation of phosphorylated Smads by inhibiting Imp 7 or Imp 8 in HepG2 cells. PMID: 29552126 Ref: Regulation of transforming growth factor is involved in the efficacy of combined 5-fluorouracil and interferon alpha-2b therapy of advanced hepatocellular carcinoma. PMID: 29560281 Ref: Molecular genomic landscapes of hepatobiliary cancer. PMID: 29573058 Ref: Low expression of c-Myc protein predicts poor outcomes in patients with hepatocellular carcinoma after resection. PMID: 29690860 Ref: The prognostic correlation between CD105 expression level in tumor tissue and peripheral blood and sunitinib administration in advanced hepatocellular carcinoma. PMID: 29799303 Ref: Hepatocellular Carcinoma Cell-Secreted Exosomal MicroRNA-210 Promotes Angiogenesis In Vitro and In Vivo. PMID: 29858059 Ref: Significance of pSmad2/3 and Smad4 in hepatitis C virus-related liver fibrosis and hepatocellular carcinoma. PMID: 29924446 Ref: MicroRNA-34a-5p inhibits liver fibrosis by regulating TGF-beta1/Smad3 pathway in hepatic stellate cells. PMID: 29957876 |