Literatures

Primary Site >> Colorectal Cancer

Gene >> SMAD4

1.
Journal:
Title:	Juvenile Polyposis Syndrome
Author:	Larsen Haidle, Joy\|Howe, James R
PMID:	20301642

2.
Journal:	Nat Genet. 1996 Jul;13(3):343-6.
Title:	Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers.
Author:	Thiagalingam, S\|Lengauer, C\|Leach, F S\|Schutte, M\|Hahn, S A\|Overhauser, J\|Willson, J K\|Markowitz, S\|Hamilton, S R\|Kern, S E\|Kinzler, K W\|Vogelstein, B
PMID:	8673134

3.
Journal:	Cell. 1996 Aug 23;86(4):543-52.
Title:	MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma.
Author:	Eppert, K\|Scherer, S W\|Ozcelik, H\|Pirone, R\|Hoodless, P\|Kim, H\|Tsui, L C\|Bapat, B\|Gallinger, S\|Andrulis, I L\|Thomsen, G H\|Wrana, J L\|Attisano, L
PMID:	8752209

4.
Journal:	Gastroenterology. 1996 Nov;111(5):1369-72.
Title:	Somatic alterations of the DPC4 gene in human colorectal cancers in vivo.
Author:	Takagi, Y\|Kohmura, H\|Futamura, M\|Kida, H\|Tanemura, H\|Shimokawa, K\|Saji, S
PMID:	8898652

5.
Journal:	Oncogene. 1996 Dec 5;13(11):2459-62.
Title:	Infrequent DPC4 gene mutation in esophageal cancer, gastric cancer and ulcerative colitis-associated neoplasms.
Author:	Lei, J\|Zou, T T\|Shi, Y Q\|Zhou, X\|Smolinski, K N\|Yin, J\|Souza, R F\|Appel, R\|Wang, S\|Cymes, K\|Chan, O\|Abraham, J M\|Harpaz, N\|Meltzer, S J
PMID:	8957088

6.
Journal:	Leukemia. 1997 Aug;11(8):1187-92.
Title:	Smad5, a tumor suppressor candidate at 5q31.1, is hemizygously lost and not mutated in the retained allele in human leukemia cell line HL60.
Author:	Zavadil, J\|Brezinova, J\|Svoboda, P\|Zemanova, Z\|Michalova, K
PMID:	9264367

7.
Journal:	Oncogene. 1997 Aug 28;15(9):1111-4.
Title:	Comparative mutational analysis of DPC4 (Smad4) in prostatic and colorectal carcinomas.
Author:	MacGrogan, D\|Pegram, M\|Slamon, D\|Bookstein, R
PMID:	9285566

8.
Journal:	Cancer Res. 1997 Sep 1;57(17):3772-8.
Title:	Expression and mutational analysis of the DCC, DPC4, and MADR2/JV18-1 genes in neuroblastoma.
Author:	Kong, X T\|Choi, S H\|Inoue, A\|Xu, F\|Chen, T\|Takita, J\|Yokota, J\|Bessho, F\|Yanagisawa, M\|Hanada, R\|Yamamoto, K\|Hayashi, Y
PMID:	9288786

9.
Journal:	Curr Probl Cancer. 1997 Sep-Oct;21(5):233-300.
Title:	Molecular biology of colorectal cancer.
Author:	Gryfe, R\|Swallow, C\|Bapat, B\|Redston, M\|Gallinger, S\|Couture, J
PMID:	9438104

10.
Journal:	Cancer Lett. 1998 Jan 9;122(1-2):157-63.
Title:	Genomic structure of the human Smad3 gene and its infrequent alterations in colorectal cancers.
Author:	Arai, T\|Akiyama, Y\|Okabe, S\|Ando, M\|Endo, M\|Yuasa, Y
PMID:	9464505

11.
Journal:	Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2412-6.
Title:	Targeted deletion of Smad4 shows it is required for transforming growth factor beta and activin signaling in colorectal cancer cells.
Author:	Zhou, S\|Buckhaults, P\|Zawel, L\|Bunz, F\|Riggins, G\|Dai, J L\|Kern, S E\|Kinzler, K W\|Vogelstein, B
PMID:	9482899

12.
Journal:	Cancer Res. 1998 Jun 1;58(11):2339-42.
Title:	Alterations in pancreatic, biliary, and breast carcinomas support MKK4 as a genetically targeted tumor suppressor gene.
Author:	Su, G H\|Hilgers, W\|Shekher, M C\|Tang, D J\|Yeo, C J\|Hruban, R H\|Kern, S E
PMID:	9622070

13.
Journal:	Leukemia. 1998 Jul;12(7):1114-8.
Title:	Mutational analysis of the tumor suppressor Smad2 in acute lymphoid and myeloid leukemia.
Author:	Wieser, R\|Gruber, B\|Rieder, H\|Fonatsch, C
PMID:	9665198

14.
Journal:	Cell. 1998 Sep 18;94(6):703-14.
Title:	Smad3 mutant mice develop metastatic colorectal cancer.
Author:	Zhu, Y\|Richardson, J A\|Parada, L F\|Graff, J M
PMID:	9753318

15.
Journal:	Br J Cancer. 1998 Dec;78(12):1615-9.
Title:	Smad4 (DPC4)--a potent tumour suppressor?
Author:	Duff, E K\|Clarke, A R
PMID:	9862572

16.
Journal:	Oncogene. 1999 May 20;18(20):3098-103.
Title:	Higher frequency of Smad4 gene mutation in human colorectal cancer with distant metastasis.
Author:	Miyaki, M\|Iijima, T\|Konishi, M\|Sakai, K\|Ishii, A\|Yasuno, M\|Hishima, T\|Koike, M\|Shitara, N\|Iwama, T\|Utsunomiya, J\|Kuroki, T\|Mori, T
PMID:	10340381

17.
Journal:	Oncogene. 1999 May 20;18(20):3152-8.
Title:	DPC4/SMAD4 mediated tumor suppression of colon carcinoma cells is associated with reduced urokinase expression.
Author:	Schwarte-Waldhoff, I\|Klein, S\|Blass-Kampmann, S\|Hintelmann, A\|Eilert, C\|Dreschers, S\|Kalthoff, H\|Hahn, S A\|Schmiegel, W
PMID:	10340387

18.
Journal:	Int J Cancer. 1999 Jul 19;82(2):197-202.
Title:	Expression of Smad proteins in human colorectal cancer.
Author:	Korchynskyi, O\|Landstrom, M\|Stoika, R\|Funa, K\|Heldin, C H\|ten Dijke, P\|Souchelnytskyi, S
PMID:	10389752

19.
Journal:	Genes Chromosomes Cancer. 1999 Aug;25(4):403-6.
Title:	Frequent 4-bp deletion in exon 9 of the SMAD4/MADH4 gene in familial juvenile polyposis patients.
Author:	Friedl, W\|Kruse, R\|Uhlhaas, S\|Stolte, M\|Schartmann, B\|Keller, K M\|Jungck, M\|Stern, M\|Loff, S\|Back, W\|Propping, P\|Jenne, D E
PMID:	10398437

20.
Journal:	Gut. 1999 Sep;45(3):406-8.
Title:	Screening SMAD1, SMAD2, SMAD3, and SMAD5 for germline mutations in juvenile polyposis syndrome.
Author:	Bevan, S\|Woodford-Richens, K\|Rozen, P\|Eng, C\|Young, J\|Dunlop, M\|Neale, K\|Phillips, R\|Markie, D\|Rodriguez-Bigas, M\|Leggett, B\|Sheridan, E\|Hodgson, S\|Iwama, T\|Eccles, D\|Bodmer, W\|Houlston, R\|Tomlinson, I
PMID:	10446110

21.
Journal:	Mutat Res. 1999 Aug;406(2-4):71-7.
Title:	Inactivation of both alleles of the DPC4/SMAD4 gene in advanced colorectal cancers: identification of seven novel somatic mutations in tumors from Japanese patients.
Author:	Koyama, M\|Ito, M\|Nagai, H\|Emi, M\|Moriyama, Y
PMID:	10479724

22.
Journal:	J Biol Chem. 1999 Nov 19;274(47):33637-43.
Title:	Smad4/DPC4 silencing and hyperactive Ras jointly disrupt transforming growth factor-beta antiproliferative responses in colon cancer cells.
Author:	Calonge, M J\|Massague, J
PMID:	10559252

23.
Journal:	Jpn J Cancer Res. 1999 Dec;90(12):1329-37.
Title:	Frequent allelic imbalance on chromosome 18q21 in early superficial colorectal cancers.
Author:	Akiyama, Y\|Arai, T\|Nagasaki, H\|Yagi, O K\|Nakahata, A\|Nakajima, T\|Ohkura, Y\|Iwai, T\|Saitoh, K\|Yuasa, Y
PMID:	10665650

24.
Journal:	Eur J Cancer Prev. 1999 Dec;8 Suppl 1:S39-47.
Title:	Sequence of molecular genetic events in colorectal tumorigenesis.
Author:	Laurent-Puig, P\|Blons, H\|Cugnenc, P H
PMID:	10772417

25.
Journal:	Curr Opin Gastroenterol. 1999 Jan;15(1):3-8.
Title:	The molecular basis of colorectal carcinogenesis.
Author:	Shattuck-Brandt, R L\|DuBois, R N
PMID:	17023910

26.
Journal:	Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):710-5.
Title:	Distinct genetic profiles in colorectal tumors with or without the CpG island methylator phenotype.
Author:	Toyota, M\|Ohe-Toyota, M\|Ahuja, N\|Issa, J P
PMID:	10639144

27.
Journal:	Oncogene. 2000 Jan 27;19(4):546-55.
Title:	DCC and SMAD4 alterations in human colorectal and pancreatic tumor dissemination.
Author:	Tarafa, G\|Villanueva, A\|Farre, L\|Rodriguez, J\|Musulen, E\|Reyes, G\|Seminago, R\|Olmedo, E\|Paules, A B\|Peinado, M A\|Bachs, O\|Capella, G
PMID:	10698524

28.
Journal:	Br J Cancer. 2000 May;82(9):1557-60.
Title:	A dominant negative mutation of transforming growth factor-beta receptor type II gene in microsatellite stable oesophageal carcinoma.
Author:	Tanaka, S\|Mori, M\|Mafune, K\|Ohno, S\|Sugimachi, K
PMID:	10789724

29.
Journal:	Br J Cancer. 2000 Oct;83(8):1015-9.
Title:	No SMAD4 hypermethylation in colorectal cancer.
Author:	Roth, S\|Laiho, P\|Salovaara, R\|Launonen, V\|Aaltonen, L A
PMID:	10993648

30.
Journal:	Biochim Biophys Acta. 2000 Oct 18;1502(2):283-96.
Title:	The 18q21 region in colorectal and pancreatic cancer: independent loss of DCC and DPC4 expression.
Author:	Barbera, V M\|Martin, M\|Marinoso, L\|Munne, A\|Carrato, A\|Real, F X\|Fabre, M
PMID:	11040453

31.
Journal:	Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 2000;32(3):239-242.
Title:	Expression of Smad4 Gene in Pichia pastoris and Identification of the Protein.
Author:	Liu, Yi-Ping\|Yang, Xiao\|Xu, Xiao-Ling\|Deng, Ji-Xian\|Cheng, Xuan\|Huang, Cui-Fen
PMID:	12075447

32.
Journal:	Am J Pathol. 2001 Feb;158(2):537-42.
Title:	Nuclear localization of Dpc4 (Madh4, Smad4) in colorectal carcinomas and relation to mismatch repair/transforming growth factor-beta receptor defects.
Author:	Montgomery, E\|Goggins, M\|Zhou, S\|Argani, P\|Wilentz, R\|Kaushal, M\|Booker, S\|Romans, K\|Bhargava, P\|Hruban, R\|Kern, S
PMID:	11159190

33.
Journal:	J Clin Pathol. 2001 Feb;54(2):126-31.
Title:	Molecular genetic alterations in hamartomatous polyps and carcinomas of patients with Peutz-Jeghers syndrome.
Author:	Entius, M M\|Keller, J J\|Westerman, A M\|van Rees, B P\|van Velthuysen, M L\|de Goeij, A F\|Wilson, J H\|Giardiello, F M\|Offerhaus, G J
PMID:	11215281

34.
Journal:	Cancer Res. 2001 Mar 15;61(6):2676-83.
Title:	Genetic pathways in the evolution of morphologically distinct colorectal neoplasms.
Author:	Yashiro, M\|Carethers, J M\|Laghi, L\|Saito, K\|Slezak, P\|Jaramillo, E\|Rubio, C\|Koizumi, K\|Hirakawa, K\|Boland, C R
PMID:	11289147

35.
Journal:	Int J Cancer. 2001 Jun 15;92(6):812-5.
Title:	Chromosome 18 deletions are common events in classical midgut carcinoid tumors.
Author:	Lollgen, R M\|Hessman, O\|Szabo, E\|Westin, G\|Akerstrom, G
PMID:	11351300

36.
Journal:	Br J Cancer. 2001 May 18;84(10):1314-6.
Title:	CDX2 mutations do not account for juvenile polyposis or Peutz-Jeghers syndrome and occur infrequently in sporadic colorectal cancers.
Author:	Woodford-Richens, K L\|Halford, S\|Rowan, A\|Bevan, S\|Aaltonen, L A\|Wasan, H\|Bicknell, D\|Bodmer, W F\|Houlston, R S\|Tomlinson, I P
PMID:	11355940

37.
Journal:	J Mol Med (Berl). 2001 Apr;79(2-3):128-32.
Title:	Loss of heterozygosity of DPC4 tumor suppressor gene in human sporadic colon cancer.
Author:	Had ija, M P\|Kapitanovic, S\|Radosevic, S\|Cacev, T\|Mirt, M\|Kovacevic, D\|Cacev, T\|Hadzija, M\|Spaventi, R\|Pavelic, K
PMID:	11357936

38.
Journal:	Genes Chromosomes Cancer. 2001 Jul;31(3):240-7.
Title:	Combined copy status of 18q21 genes in colorectal cancer shows frequent retention of SMAD7.
Author:	Boulay, J L\|Mild, G\|Reuter, J\|Lagrange, M\|Terracciano, L\|Lowy, A\|Laffer, U\|Orth, B\|Metzger, U\|Stamm, B\|Martinoli, S\|Herrmann, R\|Rochlitz, C
PMID:	11391794

39.
Journal:	Nihon Geka Gakkai Zasshi. 2001 May;102(5):370-5.
Title:	[Genetic changes in liver metastasis of colorectal cancer and their clinical application].
Author:	Yamaguchi, A
PMID:	11393998

40.
Journal:	J Gastroenterol. 2001 Jul;36(7):465-9.
Title:	KAI1, CAR, and Smad4 expression in the progression of colorectal tumor.
Author:	Mikami, T\|Ookawa, K\|Shimoyama, T\|Fukuda, S\|Saito, H\|Munakata, A
PMID:	11480790

41.
Journal:	Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9719-23. Epub 2001 Jul 31.
Title:	SMAD4 mutations in colorectal cancer probably occur before chromosomal instability, but after divergence of the microsatellite instability pathway.
Author:	Woodford-Richens, K L\|Rowan, A J\|Gorman, P\|Halford, S\|Bicknell, D C\|Wasan, H S\|Roylance, R R\|Bodmer, W F\|Tomlinson, I P
PMID:	11481457

42.
Journal:	Am J Hum Genet. 2001 Oct;69(4):704-11.
Title:	Germline mutations in BMPR1A/ALK3 cause a subset of cases of juvenile polyposis syndrome and of Cowden and Bannayan-Riley-Ruvalcaba syndromes.
Author:	Zhou, X P\|Woodford-Richens, K\|Lehtonen, R\|Kurose, K\|Aldred, M\|Hampel, H\|Launonen, V\|Virta, S\|Pilarski, R\|Salovaara, R\|Bodmer, W F\|Conrad, B A\|Dunlop, M\|Hodgson, S V\|Iwama, T\|Jarvinen, H\|Kellokumpu, I\|Kim, J C\|Leggett, B\|Markie, D\|Mecklin, J P\|Neale, K\|Phi
PMID:	11536076

43.
Journal:	J Biol Chem. 2001 Nov 16;276(46):43175-81. Epub 2001 Sep 11.
Title:	Loss of Smad4 function in pancreatic tumors: C-terminal truncation leads to decreased stability.
Author:	Maurice, D\|Pierreux, C E\|Howell, M\|Wilentz, R E\|Owen, M J\|Hill, C S
PMID:	11553622

44.
Journal:	Dis Colon Rectum. 2001 Oct;44(10):1503-8.
Title:	Loss of heterozygosity and HIV infection in patients with anal squamous-cell carcinoma.
Author:	Gervaz, P\|Efron, J\|Poza, A A\|Chun, S W\|Pham, T T\|Woodhouse, S\|Wexner, S D\|Carethers, J M
PMID:	11598481

45.
Journal:	J Biol Chem. 2002 Mar 22;277(12):9870-9. Epub 2002 Jan 9.
Title:	Transforming growth factor beta 1 induces proliferation in colon carcinoma cells by Ras-dependent, smad-independent down-regulation of p21cip1.
Author:	Yan, Zhongfa\|Kim, Geum-Yi\|Deng, Xiaobing\|Friedman, Eileen
PMID:	11784716

46.
Journal:	Gut. 2002 Jul;51(1):56-9.
Title:	Frequent loss of SMAD4/DPC4 protein in colorectal cancers.
Author:	Salovaara, R\|Roth, S\|Loukola, A\|Launonen, V\|Sistonen, P\|Avizienyte, E\|Kristo, P\|Jarvinen, H\|Souchelnytskyi, S\|Sarlomo-Rikala, M\|Aaltonen, L A
PMID:	12077092

47.
Journal:	Annu Rev Genomics Hum Genet. 2002;3:101-28.
Title:	Genetic and epigenetic alterations in colon cancer.
Author:	Grady, William M\|Markowitz, Sanford D
PMID:	12142355

48.
Journal:	Cancer Res. 2002 Aug 15;62(16):4558-61.
Title:	No effects of Smad2 (madh2) null mutation on malignant progression of intestinal polyps in Apc(delta716) knockout mice.
Author:	Takaku, Kazuaki\|Wrana, Jeffrey L\|Robertson, Elizabeth J\|Taketo, Makoto M
PMID:	12183405

49.
Journal:	Oncogene. 2002 Sep 5;21(39):6049-58.
Title:	Smad4 induces the tumor suppressor E-cadherin and P-cadherin in colon carcinoma cells.
Author:	Muller, Nicole\|Reinacher-Schick, Anke\|Baldus, Stephan\|van Hengel, Jolanda\|Berx, Geert\|Baar, Anke\|van Roy, Frans\|Schmiegel, Wolff\|Schwarte-Waldhoff, Irmgard
PMID:	12203117

50.
Journal:	Cancer Genet Cytogenet. 2002 Jul 15;136(2):129-37.
Title:	High resolution analysis of chromosome 18 alterations in ulcerative colitis-related colorectal cancer.
Author:	Terdiman, Jonathan P\|Aust, Daniela E\|Chang, Cornell G\|Willenbucher, Robert F\|Baretton, Gustavo B\|Waldman, Frederic M
PMID:	12237237

51.
Journal:	Br J Cancer. 2002 Sep 9;87(6):630-4.
Title:	SMAD4 is a predictive marker for 5-fluorouracil-based chemotherapy in patients with colorectal cancer.
Author:	Boulay, J L\|Mild, G\|Lowy, A\|Reuter, J\|Lagrange, M\|Terracciano, L\|Laffer, U\|Herrmann, R\|Rochlitz, C
PMID:	12237773

52.
Journal:	Int J Cancer. 2002 Nov 20;102(3):225-9.
Title:	Poorly differentiated adenocarcinoma and mucinous carcinoma of the colon and rectum show higher rates of loss of heterozygosity and loss of E-cadherin expression due to methylation of promoter region.
Author:	Kanazawa, Takamitsu\|Watanabe, Toshiaki\|Kazama, Shinsuke\|Tada, Toshihiro\|Koketsu, Shinichiro\|Nagawa, Hirokazu
PMID:	12397640

53.
Journal:	Ann Pathol. 2002 Sep;22(4):277-88.
Title:	[Genetic pathways in colorectal cancer: interest for the pathologist].
Author:	Piard, Francoise\|Martin, Laurent\|Chapusot, Caroline\|Ponnelle, Tibor\|Faivre, Jean
PMID:	12410150

54.
Journal:	Ann Surg Oncol. 2002 Nov;9(9):901-6.
Title:	Germline SMAD4 or BMPR1A mutations and phenotype of juvenile polyposis.
Author:	Sayed, M G\|Ahmed, A F\|Ringold, J R\|Anderson, M E\|Bair, J L\|Mitros, F A\|Lynch, H T\|Tinley, S T\|Petersen, G M\|Giardiello, F M\|Vogelstein, B\|Howe, J R
PMID:	12417513

55.
Journal:	Gastroenterol Clin Biol. 2002 Nov;26(11):1047-50.
Title:	[Juvenile polyposis coli. The usefulness of a genetic study and the role of surgical treatment].
Author:	Teniere, Paul\|Songne, Kleber\|Frebourg, Thierry\|Moguelet, Philippe\|Foulatier, Olivier\|Michot, Francis\|Le Pessot, Florence\|Le Blanc, Isabelle\|Scotte, Michel
PMID:	12483142

56.
Journal:	Cytometry B Clin Cytom. 2003 Jan;51(1):14-20.
Title:	Numerical abnormalities of chromosomes 17 and 18 in sporadic colorectal cancer: Incidence and correlation with clinical and biological findings and the prognosis of the disease.
Author:	Garcia, Jacinto\|Duran, Angel\|Tabernero, Maria Dolores\|Garcia Plaza, Asuncion\|Flores Corral, Teresa\|Najera, Maria Luisa\|Gomez-Alonso, Alberto\|Orfao, Alberto
PMID:	12500293

57.
Journal:	Genes Chromosomes Cancer. 2003 Mar;36(3):273-82.
Title:	Serrated adenomas and mixed polyposis caused by a splice acceptor deletion in the mouse Smad4 gene.
Author:	Hohenstein, Peter\|Molenaar, Lia\|Elsinga, Joyce\|Morreau, Hans\|van der Klift, Heleen\|Struijk, Ada\|Jagmohan-Changur, Shantie\|Smits, Ron\|van Kranen, Henk\|van Ommen, Gert-Jan B\|Cornelisse, Cees\|Devilee, Peter\|Fodde, Riccardo
PMID:	12557227

58.
Journal:	Br J Cancer. 2003 Feb 10;88(3):420-3.
Title:	Infrequent mutation of the tumour-suppressor gene Smad4 in early-stage colorectal cancer.
Author:	Mamot, C\|Mild, G\|Reuter, J\|Laffer, U\|Metzger, U\|Terracciano, L\|Boulay, J-L\|Herrmann, R\|Rochlitz, C
PMID:	12569386

59.
Journal:	Mamm Genome. 2003 Feb;14(2):119-29.
Title:	Exclusion of Madh2, Madh4, and Madh7 as candidates for the modifier of Min 2 (Mom2) locus.
Author:	Silverman, Karen A\|Koratkar, Revati A\|Siracusa, Linda D\|Buchberg, Arthur M
PMID:	12584607

60.
Journal:	Int J Cancer. 2003 Apr 20;104(4):446-9.
Title:	SMAD7 is a prognostic marker in patients with colorectal cancer.
Author:	Boulay, Jean-Louis\|Mild, Gabriele\|Lowy, Adam\|Reuter, Juergen\|Lagrange, Magali\|Terracciano, Luigi\|Laffer, Urban\|Herrmann, Richard\|Rochlitz, Christoph
PMID:	12584741

61.
Journal:	Oncogene. 2003 Mar 6;22(9):1317-23.
Title:	TGF-beta-induced nuclear localization of Smad2 and Smad3 in Smad4 null cancer cell lines.
Author:	Fink, Stephen P\|Mikkola, Debra\|Willson, James K V\|Markowitz, Sanford
PMID:	12618756

62.
Journal:	Biochem Biophys Res Commun. 2003 Jul 11;306(4):799-804.
Title:	Role of Smad4 (DPC4) inactivation in human cancer.
Author:	Miyaki, Michiko\|Kuroki, Toshio
PMID:	12821112

63.
Journal:	J Exp Clin Cancer Res. 2003 Jun;22(2):315-20.
Title:	Mutational analysis of TGF-beta type II receptor, Smad2, Smad3, Smad4, Smad6 and Smad7 genes in colorectal cancer.
Author:	Fukushima, T\|Mashiko, M\|Takita, K\|Otake, T\|Endo, Y\|Sekikawa, K\|Takenoshita, S
PMID:	12866583

64.
Journal:	Cancer J. 2003 Jul-Aug;9(4):302-12.
Title:	Loss of Smad signaling in human colorectal cancer is associated with advanced disease and poor prognosis.
Author:	Xie, Wen\|Rimm, David L\|Lin, Yong\|Shih, Weichung J\|Reiss, Michael
PMID:	12967141

65.
Journal:	Biosci Biotechnol Biochem. 2003 Sep;67(9):2042-4.
Title:	Activin A induces phosphorylation of Smad2 but not complex formation of Smad2 with Smad4 in human colon cancer cell line HT-29.
Author:	Pholnukulkit, Pimara\|Sonoyama, Kei\|Kawabata, Jun
PMID:	14520001

66.
Journal:	Cancer Res. 2003 Nov 15;63(22):7595-9.
Title:	Carcinogenesis in MYH-associated polyposis follows a distinct genetic pathway.
Author:	Lipton, Lara\|Halford, Sarah E\|Johnson, Victoria\|Novelli, Marco R\|Jones, Angela\|Cummings, Carole\|Barclay, Ella\|Sieber, Oliver\|Sadat, Amir\|Bisgaard, Marie-Luise\|Hodgson, Shirley V\|Aaltonen, Lauri A\|Thomas, Huw J W\|Tomlinson, Ian P M
PMID:	14633673

67.
Journal:	Oncogene. 2004 Feb 5;23(5):1021-9.
Title:	Tumor-derived C-terminal mutations of Smad4 with decreased DNA binding activity and enhanced intramolecular interaction.
Author:	Kuang, Chenzhong\|Chen, Yan
PMID:	14647410

68.
Journal:	Gastroenterology. 2004 Jan;126(1):111-21.
Title:	Bone morphogenetic protein 2 is expressed by, and acts upon, mature epithelial cells in the colon.
Author:	Hardwick, James C H\|Van Den Brink, Gijs R\|Bleuming, Sylvia A\|Ballester, Isabel\|Van Den Brande, Jan M H\|Keller, Josbert J\|Offerhaus, G Johan A\|Van Deventer, Sander J H\|Peppelenbosch, Maikel P
PMID:	14699493

69.
Journal:	Biochem J. 2004 Apr 1;379(Pt 1):209-16.
Title:	Molecular and functional consequences of Smad4 C-terminal missense mutations in colorectal tumour cells.
Author:	De Bosscher, Karolien\|Hill, Caroline S\|Nicolas, Francisco J
PMID:	14715079

70.
Journal:	Cancer Sci. 2004 Jan;95(1):12-7.
Title:	Transforming growth factor-beta signaling is differentially inhibited by Smad2D450E and Smad3D407E.
Author:	Kondo, Miki\|Suzuki, Hiroyuki\|Takehara, Kazuhiko\|Miyazono, Kohei\|Kato, Mitsuyasu
PMID:	14720321

71.
Journal:	Clin Cancer Res. 2004 Mar 1;10(5):1698-705.
Title:	Epstein-barr virus-positive gastric carcinoma has a distinct protein expression profile in comparison with epstein-barr virus-negative carcinoma.
Author:	Lee, Hye Seung\|Chang, Mee Soo\|Yang, Han-Kwang\|Lee, Byung Lan\|Kim, Woo Ho
PMID:	15014022

72.
Journal:	Mutat Res. 2004 Apr 14;548(1-2):61-73.
Title:	Status of the DPC4 tumor suppressor gene in sporadic colon adenocarcinoma of Croatian patients: identification of a novel somatic mutation.
Author:	Popovic Hadzija, Marijana\|Radosevic, Senka\|Kovacevic, Duje\|Lukac, Josip\|Hadzija, Mirko\|Spaventi, Radan\|Pavelic, Kresimir\|Kapitanovic, Sanja
PMID:	15063137

73.
Journal:	Zhejiang Da Xue Xue Bao Yi Xue Ban. 2004 Mar;33(2):108-14.
Title:	[Alterations of p53 gene and microsatellite instability in ulcerative colitis and ulcerative colitis-associated colorectal cancer].
Author:	Li, Jun\|Lai, Mao-de\|Huang, Qiong
PMID:	15067728

74.
Journal:	Oncol Rep. 2004 May;11(5):951-6.
Title:	Comparative analysis of cell adhesion molecules, cell cycle regulatory proteins, mismatch repair genes, cyclooxygenase-2, and DPC4 in carcinomas arising in inflammatory bowel disease and sporadic colon cancer.
Author:	Hill, Kalisha A\|Wang, Kim L\|Stryker, Steven J\|Gupta, Rohit\|Weinrach, David M\|Rao, M S
PMID:	15069531

75.
Journal:	J Pathol. 2004 Apr;202(4):412-20.
Title:	Loss of Smad4 correlates with loss of the invasion suppressor E-cadherin in advanced colorectal carcinomas.
Author:	Reinacher-Schick, Anke\|Baldus, Stephan E\|Romdhana, Bashra\|Landsberg, Stephanie\|Zapatka, Marc\|Monig, Stefan P\|Holscher, Arnulf H\|Dienes, Hans P\|Schmiegel, Wolff\|Schwarte-Waldhoff, Irmgard
PMID:	15095268

76.
Journal:	Pathol Res Pract. 2004;200(1):1-7.
Title:	Loss of SMAD4 function in small intestinal adenocarcinomas: comparison of genetic and immunohistochemical findings.
Author:	Blaker, Hendrik\|Aulmann, Sebastian\|Helmchen, Birgit\|Otto, Herwart F\|Rieker, Ralf J\|Penzel, Roland
PMID:	15157044

77.
Journal:	Proteomics. 2004 May;4(5):1324-34.
Title:	Tumor suppressor Smad4 mediates downregulation of the anti-adhesive invasion-promoting matricellular protein SPARC: Landscaping activity of Smad4 as revealed by a "secretome" analysis.
Author:	Volmer, Martin W\|Radacz, Yvonne\|Hahn, Stephan A\|Klein-Scory, Susanne\|Stuhler, Kai\|Zapatka, Marc\|Schmiegel, Wolff\|Meyer, Helmut E\|Schwarte-Waldhoff, Irmgard
PMID:	15188399

78.
Journal:	Zhonghua Bing Li Xue Za Zhi. 2004 Jun;33(3):247-50.
Title:	[Growth suppression of colon cancer cells in vitro by DPC4 gene expression and its mechanism].
Author:	Liu, Yang\|Wen, Ji-Fang\|Li, Jing-He\|Xiao, De-Sheng\|Hu, Zhong-Liang\|Luo, Geng-Qiu
PMID:	15256118

79.
Journal:	Exp Mol Pathol. 2004 Dec;77(3):193-200.
Title:	APC gene loss of heterozygosity, mutations, E1317Q, and I1307K germ-line variants in sporadic colon cancer in Croatia.
Author:	Kapitanovic, Sanja\|Cacev, Tamara\|Radosevic, Senka\|Spaventi, Sime\|Spaventi, Radan\|Pavelic, Kresimir
PMID:	15507235

80.
Journal:	Oncol Rep. 2004 Dec;12(6):1221-5.
Title:	Assessment of K-ras, Smad4 and p53 gene alterations in colorectal metastases and their role in the metastatic process.
Author:	Losi, Lorena\|Luppi, Gabriele\|Benhattar, Jean
PMID:	15547741

81.
Journal:	Clin Cancer Res. 2004 Dec 15;10(24):8243-9.
Title:	Coexpression of matrix metalloproteinase-7 (MMP-7) and epidermal growth factor (EGF) receptor in colorectal cancer: an EGF receptor tyrosine kinase inhibitor is effective against MMP-7-expressing cancer cells.
Author:	Mimori, Koshi\|Yamashita, Keishi\|Ohta, Mitsuhiko\|Yoshinaga, Keiji\|Ishikawa, Kenji\|Ishii, Hideshi\|Utsunomiya, Tohru\|Barnard, Graham F\|Inoue, Hiroshi\|Mori, Masaki
PMID:	15623600

82.
Journal:	World J Gastroenterol. 2005 Jan 21;11(3):348-52.
Title:	Effect of deleted pancreatic cancer locus 4 gene transfection on biological behaviors of human colorectal carcinoma cells.
Author:	Xiao, De-Sheng\|Wen, Ji-Fang\|Li, Jing-He\|Hu, Zhong-Liang\|Zheng, Hui\|Fu, Chun-Yan
PMID:	15637742

83.
Journal:	Cancer Res. 2005 Jan 1;65(1):157-65.
Title:	Acceleration of Smad2 and Smad3 phosphorylation via c-Jun NH(2)-terminal kinase during human colorectal carcinogenesis.
Author:	Yamagata, Hideo\|Matsuzaki, Koichi\|Mori, Shigeo\|Yoshida, Katsunori\|Tahashi, Yoshiya\|Furukawa, Fukiko\|Sekimoto, Go\|Watanabe, Toshihiko\|Uemura, Yoshiko\|Sakaida, Noriko\|Yoshioka, Kazuhiko\|Kamiyama, Yasuo\|Seki, Toshihito\|Okazaki, Kazuichi
PMID:	15665291

84.
Journal:	World J Surg. 2005 Mar;29(3):306-11.
Title:	TGF-beta signaling in colon cancer cells.
Author:	Li, Fazhi\|Cao, Yanna\|Townsend, Courtney M Jr\|Ko, Tien C
PMID:	15711891

85.
Journal:	Korean J Gastroenterol. 2005 Feb;45(2):78-87.
Title:	[Hereditary colorectal cancer].
Author:	Park, Jae-Gahb\|Kim, Il-Jin
PMID:	15725711

86.
Journal:	Br J Cancer. 2005 Apr 11;92(7):1193-200.
Title:	Gene expression profiling of colorectal adenomas and early invasive carcinomas by cDNA array analysis.
Author:	Nosho, K\|Yamamoto, H\|Adachi, Y\|Endo, T\|Hinoda, Y\|Imai, K
PMID:	15785755

87.
Journal:	Clin Cancer Res. 2005 Apr 1;11(7):2606-11.
Title:	SMAD4 as a prognostic marker in colorectal cancer.
Author:	Alazzouzi, Hafid\|Alhopuro, Pia\|Salovaara, Reijo\|Sammalkorpi, Heli\|Jarvinen, Heikki\|Mecklin, Jukka-Pekka\|Hemminki, Akeseli\|Schwartz, Simo Jr\|Aaltonen, Lauri A\|Arango, Diego
PMID:	15814640

88.
Journal:	Cancer Res. 2005 May 15;65(10):4228-37.
Title:	Transforming growth factor-beta suppresses nonmetastatic colon cancer through Smad4 and adaptor protein ELF at an early stage of tumorigenesis.
Author:	Tang, Yi\|Katuri, Varalakshmi\|Srinivasan, Radhika\|Fogt, Franz\|Redman, Robert\|Anand, Girish\|Said, Anan\|Fishbein, Thomas\|Zasloff, Michael\|Reddy, E Premkumar\|Mishra, Bibhuti\|Mishra, Lopa
PMID:	15899814

89.
Journal:	Proteomics. 2005 Jul;5(10):2587-601.
Title:	Differential proteome analysis of conditioned media to detect Smad4 regulated secreted biomarkers in colon cancer.
Author:	Volmer, Martin W\|Stuhler, Kai\|Zapatka, Marc\|Schoneck, Anna\|Klein-Scory, Susanne\|Schmiegel, Wolff\|Meyer, Helmut E\|Schwarte-Waldhoff, Irmgard
PMID:	15912508

90.
Journal:	Exp Cell Res. 2005 Jul 1;307(1):231-46. Epub 2005 Apr 19.
Title:	Smad7 induces tumorigenicity by blocking TGF-beta-induced growth inhibition and apoptosis.
Author:	Halder, Sunil K\|Beauchamp, R Daniel\|Datta, Pran K
PMID:	15922743

91.
Journal:	Oncology. 2005;68(2-3):246-55. Epub 2005 Jul 7.
Title:	Prognostic and predictive relevance of DNAM-1, SOCS6 and CADH-7 genes on chromosome 18q in colorectal cancer.
Author:	Storojeva, Iana\|Boulay, Jean-Louis\|Ballabeni, Pierluigi\|Buess, Martin\|Terracciano, Luigi\|Laffer, Urban\|Mild, Gabriele\|Herrmann, Richard\|Rochlitz, Christoph
PMID:	16015041

92.
Journal:	J Gastroenterol. 2005 Jul;40(7):708-15.
Title:	Analysis of SMAD4/DPC4 gene alterations in multiploid colorectal carcinomas.
Author:	Ando, Tatsuya\|Sugai, Tamotsu\|Habano, Wataru\|Jiao, Yu-Fei\|Suzuki, Kazuyuki
PMID:	16082587

93.
Journal:	Mol Cell Biol. 2005 Sep;25(18):8108-25.
Title:	Smad4 dependency defines two classes of transforming growth factor {beta} (TGF-{beta}) target genes and distinguishes TGF-{beta}-induced epithelial-mesenchymal transition from its antiproliferative and migratory responses.
Author:	Levy, Laurence\|Hill, Caroline S
PMID:	16135802

94.
Journal:	Clin Cancer Res. 2005 Sep 1;11(17):6311-6.
Title:	SMAD4 levels and response to 5-fluorouracil in colorectal cancer.
Author:	Alhopuro, Pia\|Alazzouzi, Hafid\|Sammalkorpi, Heli\|Davalos, Veronica\|Salovaara, Reijo\|Hemminki, Akseli\|Jarvinen, Heikki\|Mecklin, Jukka-Pekka\|Schwartz, Simo Jr\|Aaltonen, Lauri A\|Arango, Diego
PMID:	16144935

95.
Journal:	Clin Exp Metastasis. 2005;22(5):421-8.
Title:	Genetic and pathologic changes associated with lymphovascular invasion of colorectal adenocarcinoma.
Author:	Kim, Jin C\|Roh, Seon A\|Lee, Kang H\|Namgung, Hwan\|Kim, Jung R\|Kim, Jung S
PMID:	16283485

96.
Journal:	Cancer Genet Cytogenet. 2005 Dec;163(2):101-5.
Title:	Deletion mapping of 18q in conventional renal cell carcinoma.
Author:	Hirata, Hiroshi\|Matsuyama, Hideyasu\|Matsumoto, Hiroaki\|Korenaga, Yoshihito\|Ohmi, Chietaka\|Sakano, Shigeru\|Yoshihiro, Satoru\|Naito, Katsusuke
PMID:	16337851

97.
Journal:	Cell Signal. 2006 Jul;18(7):1041-50. Epub 2005 Nov 8.
Title:	Role of Smad proteins in the regulation of NF-kappaB by TGF-beta in colon cancer cells.
Author:	Grau, Ana M\|Datta, Pran K\|Zi, Jinghuan\|Halder, Sunil K\|Beauchamp, R Daniel
PMID:	16288847

98.
Journal:	Histol Histopathol. 2006 Jun;21(6):645-62.
Title:	Smad3 phosphoisoform-mediated signaling during sporadic human colorectal carcinogenesis.
Author:	Matsuzaki, K
PMID:	16528675

99.
Journal:	Clin Cancer Res. 2006 Mar 1;12(5):1654; author reply 1654-5.
Title:	SMAD4 levels and allelic imbalance in 18q21 in colorectal cancer.
Author:	Watanabe, Toshiaki\|Kanazawa, Takamitsu\|Kazama, Yoshihiro\|Tanaka, Junichiro\|Tanaka, Toshiaki\|Ishihara, Soichiro\|Nagawa, Hirokazu
PMID:	16533795

100.
Journal:	Cancer Res. 2006 Apr 1;66(7):3471-9.
Title:	Combined array-comparative genomic hybridization and single-nucleotide polymorphism-loss of heterozygosity analysis reveals complex changes and multiple forms of chromosomal instability in colorectal cancers.
Author:	Gaasenbeek, Michelle\|Howarth, Kimberley\|Rowan, Andrew J\|Gorman, Patricia A\|Jones, Angela\|Chaplin, Tracy\|Liu, Ying\|Bicknell, David\|Davison, Eleanor J\|Fiegler, Heike\|Carter, Nigel P\|Roylance, Rebecca R\|Tomlinson, Ian P M
PMID:	16585170

101.
Journal:	Biotechnol Appl Biochem. 2006 Jul;45(Pt 1):29-36.
Title:	A preliminary investigation demonstrating the effect of quercetin on the expression of genes related to cell-cycle arrest, apoptosis and xenobiotic metabolism in human CO115 colon-adenocarcinoma cells using DNA microarray.
Author:	Murtaza, Imtiyaz\|Marra, Giancarlo\|Schlapbach, Ralph\|Patrignani, Andrea\|Kunzli, Marzana\|Wagner, Ulrich\|Sabates, Jacob\|Dutt, Amit
PMID:	16640504

102.
Journal:	J Gastroenterol. 2006 Mar;41(3):185-92.
Title:	Colorectal cancer: genetics of development and metastasis.
Author:	Takayama, Tetsuji\|Miyanishi, Koji\|Hayashi, Tsuyoshi\|Sato, Yasushi\|Niitsu, Yoshiro
PMID:	16699851

103.
Journal:	Anticancer Res. 2006 Jan-Feb;26(1B):507-10.
Title:	SMAD4/DPC4 expression and prognosis in human colorectal cancer.
Author:	Isaksson-Mettavainio, Martin\|Palmqvist, Richard\|Forssell, Johan\|Stenling, Roger\|Oberg, Ake
PMID:	16739311

104.
Journal:	Am J Physiol Gastrointest Liver Physiol. 2006 Jul;291(1):G135-45.
Title:	Bone morphogenetic protein signaling and growth suppression in colon cancer.
Author:	Beck, Stayce E\|Jung, Barbara H\|Fiorino, Antonio\|Gomez, Jessica\|Rosario, Eunice Del\|Cabrera, Betty L\|Huang, Sherry C\|Chow, Jimmy Y C\|Carethers, John M
PMID:	16769811

105.
Journal:	Cancer Genet Cytogenet. 2006 Jul 15;168(2):98-104.
Title:	Genomic profiles of colorectal cancers differ based on patient smoking status.
Author:	Swede, Helen\|Bartos, Jeremy D\|Chen, Neng\|Shaukat, Aasma\|Dutt, Smitha S\|McQuaid, Devin A\|Natarajan, Nachimuthu\|Rodriguez-Bigas, Miguel A\|Nowak, Norma J\|Wiseman, Sam M\|Alrawi, Sadir\|Brenner, Bruce M\|Petrelli, Nicholas J\|Cummings, K Michael\|Stoler, Daniel L\|
PMID:	16843098

106.
Journal:	Free Radic Biol Med. 2006 Aug 1;41(3):443-54.
Title:	c-Jun N-terminal kinase upregulation as a key event in the proapoptotic interaction between transforming growth factor-beta1 and 4-hydroxynonenal in colon mucosa.
Author:	Biasi, Fiorella\|Vizio, Barbara\|Mascia, Cinzia\|Gaia, Ezio\|Zarkovic, Neven\|Chiarpotto, Elena\|Leonarduzzi, Gabriella\|Poli, Giuseppe
PMID:	16843825

107.
Journal:	Anticancer Res. 2006 Jul-Aug;26(4B):2901-7.
Title:	Expression of Smad4 and TGF-beta2 in colorectal carcinoma.
Author:	Kouvidou, Ch\|Latoufis, C\|Lianou, E\|Kouvatseas, G\|Kakouri, E\|Anagnostakis, D\|Vrettou-Aravani, V\|Betsi, E\|Karatapanis, S
PMID:	16886611

108.
Journal:	Anal Bioanal Chem. 2006 Nov;386(6):1603-12. Epub 2006 Oct 17.
Title:	Differential proteome analysis of colon carcinoma cell line SW480 after reconstitution of the tumour suppressor Smad4.
Author:	Stuhler, Kai\|Koper, Katharina\|Pfeiffer, Kathy\|Tagariello, Andreas\|Souquet, Manfred\|Schwarte-Waldhoff, Irmgard\|Hahn, Stephan A\|Schmiegel, Wolff\|Meyer, Helmut E
PMID:	17043799

109.
Journal:	Br J Cancer. 2006 Dec 4;95(11):1562-7. Epub 2006 Nov 7.
Title:	Chromosome 18q deletion and Smad4 protein inactivation correlate with liver metastasis: A study matched for T- and N- classification.
Author:	Tanaka, T\|Watanabe, T\|Kazama, Y\|Tanaka, J\|Kanazawa, T\|Kazama, S\|Nagawa, H
PMID:	17088901

110.
Journal:	Praxis (Bern 1994). 2006 Nov 1;95(44):1709-12.
Title:	[Pancreatic cancer].
Author:	Schmid, R M
PMID:	17111879

111.
Journal:	Acta Biochim Biophys Sin (Shanghai). 2006 Dec;38(12):883-92.
Title:	Effect of DPC4 gene on invasion and metastasis of colorectal carcinoma cells.
Author:	Xiao, De-Sheng\|Wen, Ji-Fang\|Li, Jing-He\|Wang, Kuan-Song\|Hu, Zhong-Liang\|Zhou, Jian-Hua\|Deng, Zheng-Hao\|Liu, Ying
PMID:	17151782

112.
Journal:	J Exp Clin Cancer Res. 2006 Sep;25(3):433-42.
Title:	Expression and mutation of SMAD4 in poorly differentiated carcinoma and signet-ring cell carcinoma of the colorectum.
Author:	Seshimo, I\|Yamamoto, H\|Mishima, H\|Kurata, A\|Suzuki, R\|Ezumi, K\|Takemasa, I\|Ikeda, M\|Fukushima, T\|Tsujinaka, T\|Sekimoto, M\|Kikkawa, N\|Takenoshita, S\|Monden, M
PMID:	17167985

113.
Journal:	Magy Onkol. 2006;50(4):349-59. Epub 2007 Jan 10.
Title:	[Developments in cancer management by innovative genomics. 2006 report of the National Cancer Consortium].
Author:	Timar, Jozsef\|Kasler, Miklos\|Katai, Jozsef\|Soos, Miklos\|Mathiasz, Dora\|Romany, Anna\|Patthy, Laszlo\|Kovacs, Gabor\|Jozsa, Adrienn\|Szilak, Laszlo\|Forrai, Tamas
PMID:	17216011

114.
Journal:	Cancer Lett. 2007 Mar 18;247(2):283-92. Epub 2006 Jul 7.
Title:	Genetic alterations of the TGF-beta signaling pathway in colorectal cancer cell lines: a novel mutation in Smad3 associated with the inactivation of TGF-beta-induced transcriptional activation.
Author:	Ku, Ja-Lok\|Park, Seok-Hee\|Yoon, Kyong-Ah\|Shin, Young-Kyoung\|Kim, Kyung-Hee\|Choi, Jin-Sung\|Kang, Hio-Chung\|Kim, Il-Jin\|Han, Inn-Oc\|Park, Jae-Gahb
PMID:	16828225

115.
Journal:	Int J Biochem Cell Biol. 2007;39(4):672-7. Epub 2006 Nov 3.
Title:	Colorectal cancer: potential therapeutic benefits of Vitamin D.
Author:	Jimenez-Lara, Ana M
PMID:	17157547

116.
Journal:	Exp Mol Pathol. 2007 Jun;82(3):284-91. Epub 2006 Dec 15.
Title:	Expression of TGF-beta1, TbetaRII and Smad4 in colorectal carcinoma.
Author:	Xu, Wei-Qing\|Jiang, Xu-Cheng\|Zheng, Lin\|Yu, Yin-Yan\|Tang, Jian-Min
PMID:	17289018

117.
Journal:	Cancer Res. 2007 Feb 15;67(4):1571-9.
Title:	Smad4 regulates claudin-1 expression in a transforming growth factor-beta-independent manner in colon cancer cells.
Author:	Shiou, Sheng-Ru\|Singh, Amar B\|Moorthy, Krishnan\|Datta, Pran K\|Washington, M Kay\|Beauchamp, R Daniel\|Dhawan, Punita
PMID:	17308096

118.
Journal:	J Chir (Paris). 2007 Jan-Feb;144(1):13-8.
Title:	[Colorectal carcinogenesis. 1. Hereditary predisposition and colorectal cancer].
Author:	Karoui, M\|Tresallet, C\|Brouquet, A\|Radvanyi, H\|Penna, C
PMID:	17369756

119.
Journal:	Nat Genet. 2007 Apr;39(4):467-75. Epub 2007 Mar 18.
Title:	SMAD4-deficient intestinal tumors recruit CCR1+ myeloid cells that promote invasion.
Author:	Kitamura, Takanori\|Kometani, Kohei\|Hashida, Hiroki\|Matsunaga, Akihiro\|Miyoshi, Hiroyuki\|Hosogi, Hisahiro\|Aoki, Masahiro\|Oshima, Masanobu\|Hattori, Masakazu\|Takabayashi, Arimichi\|Minato, Nagahiro\|Taketo, Makoto M
PMID:	17369830

120.
Journal:	Oncol Rep. 2007 May;17(5):1095-9.
Title:	Loss of Smad4 expression predicts liver metastasis in human colorectal cancer.
Author:	Losi, Lorena\|Bouzourene, Hanifa\|Benhattar, Jean
PMID:	17390050

121.
Journal:	Keio J Med. 2007 Mar;56(1):14-20.
Title:	Genetic testing in colorectal cancer: who, when, how and why.
Author:	Davidson, Nicholas O
PMID:	17392593

122.
Journal:	Cell Signal. 2007 Aug;19(8):1722-32. Epub 2007 Mar 28.
Title:	Proinvasive activity of BMP-7 through SMAD4/src-independent and ERK/Rac/JNK-dependent signaling pathways in colon cancer cells.
Author:	Grijelmo, Clara\|Rodrigue, Christelle\|Svrcek, Magalie\|Bruyneel, Erik\|Hendrix, An\|de Wever, Olivier\|Gespach, Christian
PMID:	17478078

123.
Journal:	J Cell Mol Med. 2007 Mar-Apr;11(2):252-85.
Title:	Pathogenesis of colorectal carcinoma and therapeutic implications: the roles of the ubiquitin-proteasome system and Cox-2.
Author:	Voutsadakis, Ioannis A
PMID:	17488476

124.
Journal:	BMC Cancer. 2007 Aug 10;7:156.
Title:	TGF-beta receptor 2 downregulation in tumour-associated stroma worsens prognosis and high-grade tumours show more tumour-associated macrophages and lower TGF-beta1 expression in colon carcinoma: a retrospective study.
Author:	Bacman, David\|Merkel, Susanne\|Croner, Roland\|Papadopoulos, Thomas\|Brueckl, Wolfgang\|Dimmler, Arno
PMID:	17692120

125.
Journal:	Br J Cancer. 2007 Nov 5;97(9):1305-9.
Title:	National study of colorectal cancer genetics.
Author:	Penegar, S\|Wood, W\|Lubbe, S\|Chandler, I\|Broderick, P\|Papaemmanuil, E\|Sellick, G\|Gray, R\|Peto, J\|Houlston, R
PMID:	17895893

126.
Journal:	Gastroenterology. 2007 Oct;133(4):1272-81. Epub 2007 Aug 14.
Title:	The effect of statins in colorectal cancer is mediated through the bone morphogenetic protein pathway.
Author:	Kodach, Liudmila L\|Bleuming, Sylvia A\|Peppelenbosch, Maikel P\|Hommes, Daniel W\|van den Brink, Gijs R\|Hardwick, James C H
PMID:	17919499

127.
Journal:	BMC Cancer. 2007 Nov 12;7:209.
Title:	High-level inducible Smad4-reexpression in the cervical cancer cell line C4-II is associated with a gene expression profile that predicts a preferential role of Smad4 in extracellular matrix composition.
Author:	Klein-Scory, Susanne\|Zapatka, Marc\|Eilert-Micus, Christina\|Hoppe, Sabine\|Schwarz, Elisabeth\|Schmiegel, Wolff\|Hahn, Stephan A\|Schwarte-Waldhoff, Irmgard
PMID:	17997817

128.
Journal:	Cytogenet Genome Res. 2007;118(2-4):214-21.
Title:	SNP-Array genotyping and spectral karyotyping reveal uniparental disomy as early mutational event in MSS- and MSI-colorectal cancer cell lines.
Author:	Melcher, R\|Al-Taie, O\|Kudlich, T\|Hartmann, E\|Maisch, S\|Steinlein, C\|Schmid, M\|Rosenwald, A\|Menzel, T\|Scheppach, W\|Luhrs, H
PMID:	18000373

129.
Journal:	Gastroenterol Hepatol. 2007 Dec;30(10):592-6.
Title:	[Genetic profile and molecular bases of pancreatic carcinogenesis].
Author:	Sanchez-Fayos Calabuig, Paloma\|Martin Relloso, Maria Jesus\|Porres Cubero, Juan Carlos
PMID:	18028855

130.
Journal:	Cancer Biol Ther. 2007 Aug;6(8):1313-7.
Title:	BMP suppresses PTEN expression via RAS/ERK signaling.
Author:	Beck, Stayce E\|Carethers, John M
PMID:	18059158

131.
Journal:	J Surg Oncol. 2008 Jan 1;97(1):69-73.
Title:	Loss of Smad4 protein expression and 18qLOH as molecular markers indicating lymph node metastasis in colorectal cancer--a study matched for tumor depth and pathology.
Author:	Tanaka, Toshiaki\|Watanabe, Toshiaki\|Kazama, Yoshihiro\|Tanaka, Junichiro\|Kanazawa, Takamitsu\|Kazama, Shinsuke\|Nagawa, Hirokazu
PMID:	17786972

132.
Journal:	Cancer. 2008 Jan 15;112(2):300-6.
Title:	The bone morphogenetic protein pathway is active in human colon adenomas and inactivated in colorectal cancer.
Author:	Kodach, Liudmila L\|Bleuming, Sylvia A\|Musler, Alex R\|Peppelenbosch, Maikel P\|Hommes, Daniel W\|van den Brink, Gijs R\|van Noesel, Carel J M\|Offerhaus, G Johan A\|Hardwick, James C H
PMID:	18008360

133.
Journal:	Prostate. 2008 May 1;68(6):661-74.
Title:	Promoter methylation correlates with reduced Smad4 expression in advanced prostate cancer.
Author:	Aitchison, Alan A\|Veerakumarasivam, Abhi\|Vias, Maria\|Kumar, Rajeev\|Hamdy, Freddie C\|Neal, David E\|Mills, Ian G
PMID:	18213629

134.
Journal:	Clin Cancer Res. 2008 Feb 1;14(3):772-81.
Title:	Progression and tumor heterogeneity analysis in early rectal cancer.
Author:	Lips, Esther H\|van Eijk, Ronald\|de Graaf, Eelco J R\|Doornebosch, Pascal G\|de Miranda, Noel F C C\|Oosting, Jan\|Karsten, Tom\|Eilers, Paul H C\|Tollenaar, Rob A E M\|van Wezel, Tom\|Morreau, Hans
PMID:	18245538

135.
Journal:	Cancer Lett. 2008 Jun 18;264(2):281-7.
Title:	Transforming growth factor beta suppresses beta-catenin/Wnt signaling and stimulates an adhesion response in human colon carcinoma cells in a Smad4/DPC4 independent manner.
Author:	Wang, Huijun\|Rajan, Shanthi\|Liu, Guangming\|Chakrabarty, Subhas
PMID:	18367323

136.
Journal:	Mod Pathol. 2008 Jul;21(7):866-75.
Title:	Expression of Smad2 and Smad4 in cervical cancer: absent nuclear Smad4 expression correlates with poor survival.
Author:	Kloth, Judith N\|Kenter, Gemma G\|Spijker, H Siebe\|Uljee, Sandra\|Corver, Willem E\|Jordanova, Ekaterina S\|Fleuren, Gert Jan\|Gorter, Arko
PMID:	18425078

137.
Journal:	Mol Pharmacol. 2008 Jul;74(1):289-97.
Title:	Selective killing of Smad4-negative tumor cells via a designed repressor strategy.
Author:	Dixit, Vidula\|Juliano, Rudy L
PMID:	18426856

138.
Journal:	Gastroenterology. 2008 May;134(5):1332-41.
Title:	The bone morphogenetic protein pathway is inactivated in the majority of sporadic colorectal cancers.
Author:	Kodach, Liudmila L\|Wiercinska, Eliza\|de Miranda, Noel F C C\|Bleuming, Sylvia A\|Musler, Alex R\|Peppelenbosch, Maikel P\|Dekker, Evelien\|van den Brink, Gijs R\|van Noesel, Carel J M\|Morreau, Hans\|Hommes, Daniel W\|Ten Dijke, Peter\|Offerhaus, G Johan A\|Hardwick
PMID:	18471510

139.
Journal:	Mol Cancer Ther. 2008 Jun;7(6):1337-46.
Title:	In vitro differential sensitivity of melanomas to phenothiazines is based on the presence of codon 600 BRAF mutation.
Author:	Ikediobi, Ogechi N\|Reimers, Mark\|Durinck, Steffen\|Blower, Paul E\|Futreal, Andrew P\|Stratton, Michael R\|Weinstein, John N
PMID:	18524847

140.
Journal:	Biochim Biophys Acta. 2008 Dec;1782(12):800-8.
Title:	The ubiquitin-proteasome system in colorectal cancer.
Author:	Voutsadakis, Ioannis A
PMID:	18619533

141.
Journal:	Cancer Biol Ther. 2008 Oct;7(10):1694-9. Epub 2008 Oct 22.
Title:	TGFbeta modulates PTEN expression independently of SMAD signaling for growth proliferation in colon cancer cells.
Author:	Chow, Jimmy Y C\|Cabral, Jennifer A\|Chang, Jessica\|Carethers, John M
PMID:	18769113

142.
Journal:	Br J Cancer. 2008 Sep 16;99(6):957-65.
Title:	Smad7 induces hepatic metastasis in colorectal cancer.
Author:	Halder, S K\|Rachakonda, G\|Deane, N G\|Datta, P K
PMID:	18781153

143.
Journal:	BMC Cancer. 2008 Oct 29;8:314.
Title:	Integrating chromosomal aberrations and gene expression profiles to dissect rectal tumorigenesis.
Author:	Lips, Esther H\|van Eijk, Ronald\|de Graaf, Eelco J R\|Oosting, Jan\|de Miranda, Noel F C C\|Karsten, Tom\|van de Velde, Cornelis J\|Eilers, Paul H C\|Tollenaar, Rob A E M\|van Wezel, Tom\|Morreau, Hans
PMID:	18959792

144.
Journal:	Lab Invest. 2009 Jan;89(1):98-105.
Title:	Matrix metalloproteinase 7 is required for tumor formation, but dispensable for invasion and fibrosis in SMAD4-deficient intestinal adenocarcinomas.
Author:	Kitamura, Takanori\|Biyajima, Kyoko\|Aoki, Masahiro\|Oshima, Masanobu\|Taketo, Makoto M
PMID:	19002110

145.
Journal:	Hum Mutat. 2009 Feb;30(2):E451-9.
Title:	Mutational profiling of cancer candidate genes in glioblastoma, melanoma and pancreatic carcinoma reveals a snapshot of their genomic landscapes.
Author:	Bleeker, Fonnet E\|Lamba, Simona\|Rodolfo, Monica\|Scarpa, Aldo\|Leenstra, Sieger\|Vandertop, W Peter\|Bardelli, Alberto
PMID:	19058223

146.
Journal:	Science. 2009 Mar 27;323(5922):1747-50.
Title:	A transposon-based genetic screen in mice identifies genes altered in colorectal cancer.
Author:	Starr, Timothy K\|Allaei, Raha\|Silverstein, Kevin A T\|Staggs, Rodney A\|Sarver, Aaron L\|Bergemann, Tracy L\|Gupta, Mihir\|O'Sullivan, M Gerard\|Matise, Ilze\|Dupuy, Adam J\|Collier, Lara S\|Powers, Scott\|Oberg, Ann L\|Asmann, Yan W\|Thibodeau, Stephen N\|Tessarollo,
PMID:	19251594

147.
Journal:	Pancreas. 2009 Jul;38(5):551-7.
Title:	Identification and characterization of a novel anticancer agent with selectivity against deleted in pancreatic cancer locus 4 (DPC4)-deficient pancreatic and colon cancer cells.
Author:	Wang, Hong\|Stephens, Bret\|Von Hoff, Daniel D\|Han, Haiyong
PMID:	19276868

148.
Journal:	Biochem Biophys Res Commun. 2009 Mar 13;380(3):478-83.
Title:	Smad4 restoration leads to a suppression of Wnt/beta-catenin signaling activity and migration capacity in human colon carcinoma cells.
Author:	Tian, Xiaoxiao\|Du, Hao\|Fu, Xiangsheng\|Li, Kang\|Li, Aimin\|Zhang, Yali
PMID:	19284991

149.
Journal:	Cancer Lett. 2009 Aug 28;281(2):220-31.
Title:	Overexpression of bone morphogenetic protein 4 enhances the invasiveness of Smad4-deficient human colorectal cancer cells.
Author:	Deng, Haiyun\|Ravikumar, T S\|Yang, Weng-Lang
PMID:	19321257

150.
Journal:	Carcinogenesis. 2009 Jun;30(6):1041-8.
Title:	Promoter CpG island hypermethylation- and H3K9me3 and H3K27me3-mediated epigenetic silencing targets the deleted in colon cancer (DCC) gene in colorectal carcinogenesis without affecting neighboring genes on chromosomal region 18q21.
Author:	Derks, Sarah\|Bosch, Linda J W\|Niessen, Hanneke E C\|Moerkerk, Peter T M\|van den Bosch, Sandra M\|Carvalho, Beatriz\|Mongera, Sandra\|Voncken, J Willem\|Meijer, Gerrit A\|de Bruine, Adriaan P\|Herman, James G\|van Engeland, Manon
PMID:	19329758

151.
Journal:	Gastroenterology. 2009 Aug;137(2):639-48, 648.e1-9.
Title:	ITF-2 is disrupted via allelic loss of chromosome 18q21, and ITF-2B expression is lost at the adenoma-carcinoma transition.
Author:	Herbst, Andreas\|Bommer, Guido T\|Kriegl, Lydia\|Jung, Andreas\|Behrens, Andrea\|Csanadi, Endy\|Gerhard, Markus\|Bolz, Christian\|Riesenberg, Rainer\|Zimmermann, Wolfgang\|Dietmaier, Wolfgang\|Wolf, Isabella\|Brabletz, Thomas\|Goke, Burkhard\|Kolligs, Frank T
PMID:	19394332

152.
Journal:	BMC Cancer. 2009 Jun 15;9:184.
Title:	Colorectal carcinomas in MUTYH-associated polyposis display histopathological similarities to microsatellite unstable carcinomas.
Author:	Nielsen, Maartje\|de Miranda, Noel F C C\|van Puijenbroek, Marjo\|Jordanova, Ekaterina S\|Middeldorp, Anneke\|van Wezel, Tom\|van Eijk, Ronald\|Tops, Carli M J\|Vasen, Hans F A\|Hes, Frederik J\|Morreau, Hans
PMID:	19527492

153.
Journal:	Pathobiology. 2009;76(4):163-9.
Title:	RUNX3 inhibits cell proliferation and induces apoptosis by TGF-beta-dependent and -independent mechanisms in human colon carcinoma cells.
Author:	Tong, Dan-Dan\|Jiang, Ying\|Li, Ming\|Kong, Dan\|Meng, Xiang-Nin\|Zhao, Yu-Zhen\|Jin, Yan\|Bai, Jing\|Fu, Song-Bin\|Geng, Jing-Shu
PMID:	19571605

154.
Journal:	Cancer Sci. 2009 Nov;100(11):2133-42.
Title:	Promoter-wide analysis of Smad4 binding sites in human epithelial cells.
Author:	Koinuma, Daizo\|Tsutsumi, Shuichi\|Kamimura, Naoko\|Imamura, Takeshi\|Aburatani, Hiroyuki\|Miyazono, Kohei
PMID:	19686287

155.
Journal:	Acta Med Port. 2009 May-Jun;22(3):207-14. Epub 2009 Jul 15.
Title:	[Familial colorectal cancer type X: clinical, pathological and molecular characterization].
Author:	Ferreira, Sara\|Lage, Pedro\|Sousa, Rita\|Claro, Isabel\|Francisco, Ines\|Filipe, Bruno\|Suspiro, Alexandra\|Chaves, Paula\|Rodrigues, Paula\|Albuquerque, Cristina\|Nobre Leitao, C
PMID:	19686620

156.
Journal:	Clin Cancer Res. 2009 Sep 1;15(17):5528-33.
Title:	Tissue biomarker development in a multicentre trial context: a feasibility study on the PETACC3 stage II and III colon cancer adjuvant treatment trial.
Author:	Bosman, Fred T\|Yan, Pu\|Tejpar, Sabine\|Fiocca, Roberto\|Van Cutsem, Eric\|Kennedy, Richard D\|Dietrich, Daniel\|Roth, Arnaud
PMID:	19690194

157.
Journal:	Endoscopy. 2009 Nov;41(11):1001-4.
Title:	Capsule endoscopy for the small bowel in juvenile polyposis syndrome: a case series.
Author:	Postgate, A J\|Will, O C\|Fraser, C H\|Fitzpatrick, A\|Phillips, R K S\|Clark, S K
PMID:	19816839

158.
Journal:	Diagn Mol Pathol. 2009 Dec;18(4):219-25.
Title:	Chromosome 18q deletion as a novel molecular predictor for colorectal cancer with simultaneous hepatic metastasis.
Author:	Tanaka, Toshiaki\|Watanabe, Toshiaki\|Kitayama, Joji\|Kanazawa, Takamitsu\|Kazama, Yoshihiro\|Tanaka, Junichiro\|Kazama, Shinsuke\|Nagawa, Hirokazu
PMID:	19861895

159.
Journal:	Curr Colorectal Cancer Rep. 2009 Oct 1;5(4):209.
Title:	New Therapeutics Targeting Colon Cancer Stem Cells.
Author:	Thenappan, Arun\|Li, Ying\|Shetty, Kirti\|Johnson, Lynt\|Reddy, E P\|Mishra, Lopa
PMID:	20148131

160.
Journal:	Mol Med Rep. 2009 Jan-Feb;2(1):13-5.
Title:	Alteration of SMAD4 does not participate in tumorigenesis of adenoid cystic carcinoma of the salivary gland.
Author:	Daa, Tsutomu\|Yada, Naomi\|Kashima, Kenji\|Suzuki, Masashi\|Yokoyama, Shigeo
PMID:	21475783

161.
Journal:	Colorectal Dis. 2010 Mar;12(3):213-9.
Title:	The role of SMAD4 in early-onset colorectal cancer.
Author:	Royce, S G\|Alsop, K\|Haydon, A\|Mead, L\|Smith, L D\|Tesoriero, A A\|Giles, G G\|Jenkins, M A\|Hopper, J L\|Southey, M C
PMID:	19183329

162.
Journal:	Colorectal Dis. 2010 Jun;12(6):570-3.
Title:	Hereditary mixed polyposis syndrome due to a BMPR1A mutation.
Author:	O'Riordan, J M\|O'Donoghue, D\|Green, A\|Keegan, D\|Hawkes, L A\|Payne, S J\|Sheahan, K\|Winter, D C
PMID:	19438883

163.
Journal:	Nucleic Acids Res. 2010 Jan;38(2):e9.
Title:	Random DNA fragmentation allows detection of single-copy, single-exon alterations of copy number by oligonucleotide array CGH in clinical FFPE samples.
Author:	Hostetter, Galen\|Kim, Su Young\|Savage, Stephanie\|Gooden, Gerald C\|Barrett, Michael\|Zhang, Jian\|Alla, Lalitamba\|Watanabe, April\|Einspahr, Janine\|Prasad, Anil\|Nickoloff, Brian J\|Carpten, John\|Trent, Jeffrey\|Alberts, David\|Bittner, Michael
PMID:	19875416

164.
Journal:	Gastroenterology. 2010 Mar;138(3):969-80.e1-3.
Title:	Antimetastatic role of Smad4 signaling in colorectal cancer.
Author:	Zhang, Bixiang\|Halder, Sunil K\|Kashikar, Nilesh D\|Cho, Yong-Jig\|Datta, Arunima\|Gorden, D Lee\|Datta, Pran K
PMID:	19909744

165.
Journal:	Gastroenterology. 2010 Apr;138(4):1406-17.
Title:	Epithelial to mesenchymal transition is impaired in colon cancer cells with microsatellite instability.
Author:	Pino, Maria S\|Kikuchi, Hirotoshi\|Zeng, Min\|Herraiz, Maria-Teresa\|Sperduti, Isabella\|Berger, David\|Park, Do-Youn\|Iafrate, A John\|Zukerberg, Lawrence R\|Chung, Daniel C
PMID:	20026115

166.
Journal:	PLoS One. 2010 Jan 26;5(1):e8879.
Title:	Distinct genetic alterations in colorectal cancer.
Author:	Ashktorab, Hassan\|Schaffer, Alejandro A\|Daremipouran, Mohammad\|Smoot, Duane T\|Lee, Edward\|Brim, Hassan
PMID:	20126641

167.
Journal:	Int J Colorectal Dis. 2010 May;25(5):591-9.
Title:	Role of TGF-beta1, its receptor TGFbetaRII, and Smad proteins in the progression of colorectal cancer.
Author:	Gulubova, Maya\|Manolova, Irena\|Ananiev, Julian\|Julianov, Alexander\|Yovchev, Yovcho\|Peeva, Katya
PMID:	20165854

168.
Journal:	Surg Today. 2010 Mar;40(3):245-50.
Title:	Assessment of SMAD4, p53, and Ki-67 alterations as a predictor of liver metastasis in human colorectal cancer.
Author:	Kawakami, Masayo\|Yamaguchi, Tatsuro\|Takahashi, Keiichi\|Matsumoto, Hiroshi\|Yasutome, Michiya\|Horiguchi, Shinichiro\|Hayashi, Yukiko\|Funata, Nobuaki\|Mori, Takeo
PMID:	20180078

169.
Journal:	Chem Biol Drug Des. 2010 Apr;75(4):360-8.
Title:	Chemogenomic analysis identifies Macbecin II as a compound specific for SMAD4-negative colon cancer cells.
Author:	Kaiser, Christine\|Meurice, Nathalie\|Gonzales, Irma M\|Arora, Shilpi\|Beaudry, Christian\|Bisanz, Kristen M\|Robeson, Alexander C\|Petit, Joachim\|Azorsa, David O
PMID:	20331650

170.
Journal:	Cancer Res. 2010 May 15;70(10):4243-52.
Title:	Role of RUNX3 in bone morphogenetic protein signaling in colorectal cancer.
Author:	Lee, Cecilia Wei Lin\|Ito, Kosei\|Ito, Yoshiaki
PMID:	20442291

171.
Journal:	Cancer Treat Res. 2010;155:85-103.
Title:	Tgf-beta signaling alterations and colon cancer.
Author:	Bellam, Naresh\|Pasche, Boris
PMID:	20517689

172.
Journal:	BMC Cancer. 2010 Jun 17;10:300.
Title:	SMAD4--molecular gladiator of the TGF-beta signaling is trampled upon by mutational insufficiency in colorectal carcinoma of Kashmiri population: an analysis with relation to KRAS proto-oncogene.
Author:	Sameer, A Syed\|Chowdri, Nissar A\|Syeed, Nidda\|Banday, Mujeeb Z\|Shah, Zaffar A\|Siddiqi, Mushtaq A
PMID:	20565773

173.
Journal:	Carcinogenesis. 2010 Sep;31(9):1541-51.
Title:	Smad4 loss is associated with fewer S100A8-positive monocytes in colorectal tumors and attenuated response to S100A8 in colorectal and pancreatic cancer cells.
Author:	Ang, Chin Wee\|Nedjadi, Taoufik\|Sheikh, Adnan A\|Tweedle, Elizabeth M\|Tonack, Sarah\|Honap, Sailish\|Jenkins, Rosalind E\|Park, B Kevin\|Schwarte-Waldhoff, Irmgard\|Khattak, Ilyas\|Azadeh, Bahram\|Dodson, Andrew\|Kalirai, Helen\|Neoptolemos, John P\|Rooney, Paul S\|Co
PMID:	20622003

174.
Journal:	Clin Cancer Res. 2010 Aug 15;16(16):4126-34.
Title:	SMAD4 immunohistochemistry reflects genetic status in juvenile polyposis syndrome.
Author:	Langeveld, Danielle\|van Hattem, W Arnout\|de Leng, Wendy W J\|Morsink, Folkert H\|Ten Kate, Fiebo J W\|Giardiello, Francis M\|Offerhaus, G Johan A\|Brosens, Lodewijk A A
PMID:	20682711

175.
Journal:	Anticancer Res. 2010 Jul;30(7):2603-13.
Title:	SMAD4 mediates mesenchymal-epithelial reversion in SW480 colon carcinoma cells.
Author:	Pohl, Michael\|Radacz, Yvonne\|Pawlik, Nicole\|Schoeneck, Anna\|Baldus, Stephan E\|Munding, Johanna\|Schmiegel, Wolff\|Schwarte-Waldhoff, Irmgard\|Reinacher-Schick, Anke
PMID:	20682989

176.
Journal:	BMC Cancer. 2010 Aug 13;10:426.
Title:	Distinguishing between cancer driver and passenger gene alteration candidates via cross-species comparison: a pilot study.
Author:	Ji, Xinglai\|Tang, Jie\|Halberg, Richard\|Busam, Dana\|Ferriera, Steve\|Pena, Maria Marjorette O\|Venkataramu, Chinnambally\|Yeatman, Timothy J\|Zhao, Shaying
PMID:	20707908

177.
Journal:	J Mol Diagn. 2010 Sep;12(5):552-61.
Title:	Gene dysregulations driven by somatic copy number aberrations-biological and clinical implications in colon tumors: a paper from the 2009 William Beaumont Hospital Symposium on Molecular Pathology.
Author:	Bacolod, Manny D\|Barany, Francis
PMID:	20709793

178.
Journal:	Mol Biosyst. 2010 Nov;6(11):2332-8.
Title:	Proteomics of Smad4 regulated transforming growth factor-beta signalling in colon cancer cells.
Author:	Ali, Naveid Ahmad\|McKay, Matthew John\|Molloy, Mark Paul
PMID:	20862427

179.
Journal:	Gastroenterology. 2011 Jan;140(1):297-309.
Title:	Bone morphogenetic protein 4 induces differentiation of colorectal cancer stem cells and increases their response to chemotherapy in mice.
Author:	Lombardo, Ylenia\|Scopelliti, Alessandro\|Cammareri, Patrizia\|Todaro, Matilde\|Iovino, Flora\|Ricci-Vitiani, Lucia\|Gulotta, Gaspare\|Dieli, Francesco\|de Maria, Ruggero\|Stassi, Giorgio
PMID:	20951698

180.
Journal:	Cancer Epidemiol. 2011 Jun;35(3):265-71.
Title:	Structural and functional analysis of SMAD4 gene promoter in malignant pancreatic and colorectal tissues: detection of two novel polymorphic nucleotide repeats.
Author:	Nikolic, Aleksandra\|Kojic, Snezana\|Knezevic, Srbislav\|Krivokapic, Zoran\|Ristanovic, Momcilo\|Radojkovic, Dragica
PMID:	21036691

181.
Journal:	Mol Carcinog. 2011 Jan;50(1):8-15.
Title:	Expression analysis of proline rich 15 (Prr15) in mouse and human gastrointestinal tumors.
Author:	Meunier, Dominique\|Patra, Kalicharan\|Smits, Ron\|Hagebarth, Andrea\|Luttges, Angela\|Jaussi, Rolf\|Wieduwilt, Matthew J\|Quintanilla-Fend, Leticia\|Himmelbauer, Heinz\|Fodde, Riccardo\|Fundele, Reinald H
PMID:	21061267

182.
Journal:	Cancer Epidemiol Biomarkers Prev. 2011 Jan;20(1):57-69.
Title:	Genetic variation in the TGF-beta signaling pathway and colon and rectal cancer risk.
Author:	Slattery, Martha L\|Herrick, Jennifer S\|Lundgreen, Abbie\|Wolff, Roger K
PMID:	21068203

183.
Journal:	Cancer Res. 2011 Feb 1;71(3):998-1008.
Title:	Smad4 inactivation promotes malignancy and drug resistance of colon cancer.
Author:	Papageorgis, Panagiotis\|Cheng, Kuanghung\|Ozturk, Sait\|Gong, Yi\|Lambert, Arthur W\|Abdolmaleky, Hamid M\|Zhou, Jin-Rong\|Thiagalingam, Sam
PMID:	21245094

184.
Journal:	Ann Surg Oncol. 2011 Dec;18(13):3694-700.
Title:	Molecular profiling of colon tumors: the search for clinically relevant biomarkers of progression, prognosis, therapeutics, and predisposition.
Author:	Bacolod, Manny D\|Barany, Francis
PMID:	21347779

185.
Journal:	Cancer. 2011 Sep 15;117(18):4175-83.
Title:	Genetic variation in the transforming growth factor-beta signaling pathway and survival after diagnosis with colon and rectal cancer.
Author:	Slattery, Martha L\|Lundgreen, Abbie\|Herrick, Jennifer S\|Wolff, Roger K\|Caan, Bette J
PMID:	21365634

186.
Journal:	BMC Cancer. 2011 Apr 14;11:137.
Title:	Keratin 23, a novel DPC4/Smad4 target gene which binds 14-3-3epsilon.
Author:	Liffers, Sven-T\|Maghnouj, Abdelouahid\|Munding, Johanna B\|Jackstadt, Rene\|Herbrand, Ulrike\|Schulenborg, Thomas\|Marcus, Katrin\|Klein-Scory, Susanne\|Schmiegel, Wolff\|Schwarte-Waldhoff, Irmgard\|Meyer, Helmut E\|Stuhler, Kai\|Hahn, Stephan A
PMID:	21492476

187.
Journal:	Mol Med Rep. 2011 Jul-Aug;4(4):627-31.
Title:	Analysis of the role of the BMP7-Smad4-Id2 signaling pathway in SW480 colorectal carcinoma cells.
Author:	Shi, Qiang\|Zhong, Yun-Shi\|Ren, Zhong\|Li, Quan-Lin\|Zhou, Ping-Hong\|Xu, Mei-Dong\|Yao, Li-Qing
PMID:	21523323

188.
Journal:	Saudi J Gastroenterol. 2011 Jul-Aug;17(4):297.
Title:	SMAD4 promoter hypermethylation in Kashmiri colorectal cancer cases.
Author:	Sameer, Aga S\|Siddiqi, Mushtaq A
PMID:	21727743

189.
Journal:	Proteomics. 2011 Aug;11(16):3390-401.
Title:	Quantitative phosphoproteomics of transforming growth factor-beta signaling in colon cancer cells.
Author:	Ali, Naveid A\|Molloy, Mark P
PMID:	21751366

190.
Journal:	J Gastrointest Surg. 2011 Nov;15(11):2001-10.
Title:	Roles of VEGF-C and Smad4 in the lymphangiogenesis, lymphatic metastasis, and prognosis in colon cancer.
Author:	Li, Xuemei\|Liu, Baoquan\|Xiao, Jianbing\|Yuan, Ying\|Ma, Jing\|Zhang, Yafang
PMID:	21786062

191.
Journal:	Fam Cancer. 2011 Dec;10(4):623-31.
Title:	Familial colorectal cancer type X syndrome: two distinct molecular entities?
Author:	Francisco, Ines\|Albuquerque, Cristina\|Lage, Pedro\|Belo, Helio\|Vitoriano, Ines\|Filipe, Bruno\|Claro, Isabel\|Ferreira, Sara\|Rodrigues, Paula\|Chaves, Paula\|Leitao, Carlos Nobre\|Pereira, Antonio Dias
PMID:	21837511

192.
Journal:	Genome Biol. 2011 Oct 19;12(10):R103.
Title:	Chromothripsis is a common mechanism driving genomic rearrangements in primary and metastatic colorectal cancer.
Author:	Kloosterman, Wigard P\|Hoogstraat, Marlous\|Paling, Oscar\|Tavakoli-Yaraki, Masoumeh\|Renkens, Ivo\|Vermaat, Joost S\|van Roosmalen, Markus J\|van Lieshout, Stef\|Nijman, Isaac J\|Roessingh, Wijnand\|van 't Slot, Ruben\|van de Belt, Jose\|Guryev, Victor\|Koudijs, Marc
PMID:	22014273

193.
Journal:	Hepatogastroenterology. 2011 Nov-Dec;58(112):1933-6.
Title:	Smad4 may help to identify a subset of colorectal cancer patients with early recurrence after curative therapy.
Author:	Ahn, Byung Kyu\|Jang, Si-Hyong\|Paik, Seung Sam\|Lee, Kang Hong
PMID:	22024061

194.
Journal:	World J Gastroenterol. 2011 Sep 21;17(35):3994-4000.
Title:	Association of overexpression of TIF1gamma with colorectal carcinogenesis and advanced colorectal adenocarcinoma.
Author:	Jain, Shilpa\|Singhal, Shashideep\|Francis, Franto\|Hajdu, Cristina\|Wang, Jin-Hua\|Suriawinata, Arief\|Wang, Yin-Quan\|Zhang, Miao\|Weinshel, Elizabeth H\|Francois, Fritz\|Pei, Zhi-Heng\|Lee, Peng\|Xu, Ru-Liang
PMID:	22046087

195.
Journal:	Cell Death Dis. 2011 Dec 1;2:e235.
Title:	Novel tumor suppressive function of Smad4 in serum starvation-induced cell death through PAK1-PUMA pathway.
Author:	Lee, S-H\|Jung, Y-S\|Chung, J-Y\|Oh, A Y\|Lee, S-J\|Choi, D H\|Jang, S M\|Jang, K-S\|Paik, S S\|Ha, N-C\|Park, B-J
PMID:	22130069

196.
Journal:	World J Gastroenterol. 2011 Nov 28;17(44):4839-44.
Title:	Juvenile polyposis syndrome.
Author:	Brosens, Lodewijk Aa\|Langeveld, Danielle\|van Hattem, W Arnout\|Giardiello, Francis M\|Offerhaus, G Johan A
PMID:	22171123

197.
Journal:	Mol Med Rep. 2012 Jan;5(1):89-95.
Title:	Down-regulation of Smad4 enhances proliferation and invasion of colorectal carcinoma HCT116 cells and up-regulates Id2.
Author:	Shi, Qiang\|Zhong, Yun-Shi\|Yao, Li-Qing\|Li, Quan-Lin\|Ren, Zhong\|Liu, Xiang-Ping\|Shi, Fa-Mao
PMID:	21956276

198.
Journal:	Int J Cancer. 2012 Aug 15;131(4):779-88.
Title:	High SMAD4 levels appear in microsatellite instability and hypermethylated colon cancers, and indicate a better prognosis.
Author:	Isaksson-Mettavainio, Martin\|Palmqvist, Richard\|Dahlin, Anna M\|Van Guelpen, Bethany\|Rutegard, Jorgen\|Oberg, Ake\|Henriksson, Maria L
PMID:	21964812

199.
Journal:	Gastroenterology. 2012 Mar;142(3):562-571.e2.
Title:	Smad4-mediated signaling inhibits intestinal neoplasia by inhibiting expression of beta-catenin.
Author:	Freeman, Tanner J\|Smith, J Joshua\|Chen, Xi\|Washington, M Kay\|Roland, Joseph T\|Means, Anna L\|Eschrich, Steven A\|Yeatman, Timothy J\|Deane, Natasha G\|Beauchamp, R Daniel
PMID:	22115830

200.
Journal:	Tumour Biol. 2012 Aug;33(4):1005-14.
Title:	Prognostic significance of transforming growth factor beta (TGF-beta) signaling axis molecules and E-cadherin in colorectal cancer.
Author:	Lampropoulos, Pavlos\|Zizi-Sermpetzoglou, Adamantia\|Rizos, Spyros\|Kostakis, Alkiviadis\|Nikiteas, Nikolaos\|Papavassiliou, Athanasios G
PMID:	22278155

201.
Journal:	J Gastroenterol. 2012 Jul;47(7):795-804.
Title:	Juvenile polyposis, hereditary hemorrhagic telangiectasia, and early onset colorectal cancer in patients with SMAD4 mutation.
Author:	Schwenter, Frank\|Faughnan, Marie E\|Gradinger, Abigail B\|Berk, Terri\|Gryfe, Robert\|Pollett, Aaron\|Cohen, Zane\|Gallinger, Steven\|Durno, Carol
PMID:	22331366

202.
Journal:	J BUON. 2012 Jan-Mar;17(1):92-6.
Title:	Expression of Smad4, E-cadherin and beta-catenin in advanced colorectal cancer: a retrospective study.
Author:	Diab, A\|Nikolopoulou-Stamati, P\|Katostaras, T\|Safioleas, M\|Kostakis, A\|Athanassiadou, P\|Liossi-Ioakeim, A\|Marinos, G\|Konstantopoulos, K
PMID:	22517699

203.
Journal:	PLoS One. 2012;7(6):e39381.
Title:	Effects of activin and TGFbeta on p21 in colon cancer.
Author:	Bauer, Jessica\|Sporn, Judith C\|Cabral, Jennifer\|Gomez, Jessica\|Jung, Barbara
PMID:	22761777

204.
Journal:	Dis Colon Rectum. 2012 Aug;55(8):886-92.
Title:	The prevalence of hereditary hemorrhagic telangiectasia in juvenile polyposis syndrome.
Author:	O'Malley, Margaret\|LaGuardia, Lisa\|Kalady, Matthew F\|Parambil, Joseph\|Heald, Brandie\|Eng, Charis\|Church, James\|Burke, Carol A
PMID:	22810475

205.
Journal:	Nature. 2012 Jul 18;487(7407):330-7.
Title:	Comprehensive molecular characterization of human colon and rectal cancer.
Author:
PMID:	22810696

206.
Journal:	PLoS One. 2012;7(7):e42001.
Title:	A comprehensive characterization of genome-wide copy number aberrations in colorectal cancer reveals novel oncogenes and patterns of alterations.
Author:	Xie, Tao\|D' Ario, Giovanni\|Lamb, John R\|Martin, Eric\|Wang, Kai\|Tejpar, Sabine\|Delorenzi, Mauro\|Bosman, Fred T\|Roth, Arnaud D\|Yan, Pu\|Bougel, Stephanie\|Di Narzo, Antonio Fabio\|Popovici, Vlad\|Budinska, Eva\|Mao, Mao\|Weinrich, Scott L\|Rejto, Paul A\|Hodgson, J
PMID:	22860045

207.
Journal:	J Prev Med Public Health. 2012 Jul;45(4):251-8.
Title:	Quantitative analysis of cancer-associated gene methylation connected to risk factors in Korean colorectal cancer patients.
Author:	Kang, Ho-Jin\|Kim, Eun-Jeong\|Kim, Byoung-Gwon\|You, Chang-Hun\|Lee, Sang-Yong\|Kim, Dong-Il\|Hong, Young-Seoub
PMID:	22880157

208.
Journal:	Dis Colon Rectum. 2012 Oct;55(10):1038-43.
Title:	Juvenile polyposis syndrome: a study of genotype, phenotype, and long-term outcome.
Author:	Latchford, Andrew R\|Neale, Kay\|Phillips, Robin K S\|Clark, Susan K
PMID:	22965402

209.
Journal:	Ann Clin Lab Sci. 2012 Fall;42(4):401-8.
Title:	SMAD4 haploinsufficiency associates with augmented colonic inflammation in select humans and mice.
Author:	Szigeti, Reka\|Pangas, Stephanie A\|Nagy-Szakal, Dorottya\|Dowd, Scot E\|Shulman, Robert J\|Olive, Anthony P\|Popek, Edwina J\|Finegold, Milton J\|Kellermayer, Richard
PMID:	23090737

210.
Journal:	J Gastrointest Oncol. 2012 Dec;3(4):362-8.
Title:	The real face of juvenile polyposis syndrome.
Author:	Tam, Beatrix\|Salamon, Agnes\|Bajtai, Attila\|Nemeth, Annamaria\|Kiss, Janos\|Simon, Laszlo\|Molnar, Tamas
PMID:	23205314

211.
Journal:	Cancer Res. 2013 Jan 15;73(2):725-35.
Title:	SMAD2, SMAD3 and SMAD4 mutations in colorectal cancer.
Author:	Fleming, Nicholas I\|Jorissen, Robert N\|Mouradov, Dmitri\|Christie, Michael\|Sakthianandeswaren, Anuratha\|Palmieri, Michelle\|Day, Fiona\|Li, Shan\|Tsui, Cary\|Lipton, Lara\|Desai, Jayesh\|Jones, Ian T\|McLaughlin, Stephen\|Ward, Robyn L\|Hawkins, Nicholas J\|Ruszkiew
PMID:	23139211

212.
Journal:	Hepatogastroenterology. 2013 Jun;60(124):715-9.
Title:	TGF-beta promotes colorectal cancer cell growth in vitro and in vivo.
Author:	Sun, Gang\|Cao, Dachun\|Sun, Zhixin\|Zhou, Kun\|Wang, Yu\|Liu, Hailin
PMID:	23178467

213.
Journal:	Invest New Drugs. 2013 Jun;31(3):576-86.
Title:	Characterization of a membrane-active anti-tumor agent, UA8967.
Author:	Dorr, Robert T\|Samulitis, Betty K\|Wisner, Lee\|Han, Haiyong\|Zhao, Yu\|Beroza, Paul\|Damodaran, Komath\|Igarashi, Suzu\|Landowski, Terry H\|Von Hoff, Daniel D
PMID:	23179338

214.
Journal:	PLoS One. 2013;8(2):e55532.
Title:	The oncogenic role of microRNA-130a/301a/454 in human colorectal cancer via targeting Smad4 expression.
Author:	Liu, Lin\|Nie, Jing\|Chen, Lin\|Dong, Guanglong\|Du, Xiaohui\|Wu, Xin\|Tang, Yun\|Han, Weidong
PMID:	23393589

215.
Journal:	Eur J Cancer Prev. 2013 Sep;22(5):420-4.
Title:	Evaluation of the prognostic value of pSMAD immunohistochemistry in colorectal cancer.
Author:	Voorneveld, Philip W\|Jacobs, Rutger J\|De Miranda, Noel F C C\|Morreau, Hans\|van Noesel, Carel J M\|Offerhaus, G Johan A\|Kodach, Liudmila L\|Hardwick, James C H
PMID:	23426176

216.
Journal:	Oncol Rep. 2013 May;29(5):1827-34.
Title:	Analysis of genomic aberrations associated with the clinicopathological parameters of rectal cancer by arraybased comparative genomic hybridization.
Author:	Liang, Jian-Wei\|Shi, Zhi-Zhou\|Zhang, Tong-Tong\|Hao, Jia-Jie\|Wang, Zheng\|Wang, Xiao-Min\|Yang, Hai\|Wang, Ming-Rong\|Zhou, Zhi-Xiang\|Zhang, Yu
PMID:	23440507

217.
Journal:	Scand J Gastroenterol. 2013 Jun;48(6):672-8.
Title:	Exome sequencing in diagnostic evaluation of colorectal cancer predisposition in young patients.
Author:	Tanskanen, Tomas\|Gylfe, Alexandra E\|Katainen, Riku\|Taipale, Minna\|Renkonen-Sinisalo, Laura\|Mecklin, Jukka-Pekka\|Jarvinen, Heikki\|Tuupanen, Sari\|Kilpivaara, Outi\|Vahteristo, Pia\|Aaltonen, Lauri A
PMID:	23544471

218.
Journal:	Int J Oncol. 2013 Jul;43(1):228-36.
Title:	The role of a ginseng saponin metabolite as a DNA methyltransferase inhibitor in colorectal cancer cells.
Author:	Kang, Kyoung Ah\|Kim, Hee Sun\|Kim, Dong Hyun\|Hyun, Jin Won
PMID:	23652987

219.
Journal:	Genet Mol Res. 2013 Apr 10;12(2):1106-18.
Title:	S-adenosylmethionine, a methyl donor, up regulates tissue inhibitor of metalloproteinase-2 in colorectal cancer.
Author:	Hussain, Z\|Khan, M I\|Shahid, M\|Almajhdi, F N
PMID:	23661436

220.
Journal:	J Mol Histol. 2013 Dec;44(6):679-92.
Title:	The density of macrophages in colorectal cancer is inversely correlated to TGF-beta1 expression and patients' survival.
Author:	Gulubova, Maya\|Ananiev, Julian\|Yovchev, Yovchev\|Julianov, Aleksander\|Karashmalakov, Anatoli\|Vlaykova, Tatyana
PMID:	23801404

221.
Journal:	Gastroenterology. 2013 Nov;145(5):1064-1075.e11.
Title:	Loss of SMAD4 from colorectal cancer cells promotes CCL15 expression to recruit CCR1+ myeloid cells and facilitate liver metastasis.
Author:	Itatani, Yoshiro\|Kawada, Kenji\|Fujishita, Teruaki\|Kakizaki, Fumihiko\|Hirai, Hideyo\|Matsumoto, Takuya\|Iwamoto, Masayoshi\|Inamoto, Susumu\|Hatano, Etsuro\|Hasegawa, Suguru\|Maekawa, Taira\|Uemoto, Shinji\|Sakai, Yoshiharu\|Taketo, Makoto Mark
PMID:	23891973

222.
Journal:	Expert Rev Mol Diagn. 2013 Jul;13(6):581-99.
Title:	Colorectal cancer diagnostics: biomarkers, cell-free DNA, circulating tumor cells and defining heterogeneous populations by single-cell analysis.
Author:	Kin, Cindy\|Kidess, Evelyn\|Poultsides, George A\|Visser, Brendan C\|Jeffrey, Stefanie S
PMID:	23895128

223.
Journal:	PLoS One. 2013 Jul 29;8(7):e68744.
Title:	MicroRNA-224 targets SMAD family member 4 to promote cell proliferation and negatively influence patient survival.
Author:	Wang, Yu\|Ren, Jianwei\|Gao, Yun\|Ma, Joel Z I\|Toh, Han Chong\|Chow, Pierce\|Chung, Alexander Y F\|Ooi, London L P J\|Lee, Caroline G L
PMID:	23922662

224.
Journal:	Br J Cancer. 2013 Oct 1;109(7):1805-12.
Title:	Reduced expression of bone morphogenetic protein receptor IA in pancreatic cancer is associated with a poor prognosis.
Author:	Voorneveld, P W\|Stache, V\|Jacobs, R J\|Smolders, E\|Sitters, A I\|Liesker, A\|Korkmaz, K S\|Lam, S M\|De Miranda, N F C C\|Morreau, H\|Kodach, L L\|Hardwick, J C H
PMID:	23969729

225.
Journal:	Asian Pac J Cancer Prev. 2013;14(7):4249-54.
Title:	Effects of parafibromin expression on the phenotypes and relevant mechanisms in the DLD-1 colon carcinoma cell line.
Author:	Zhao, Shuang\|Sun, Hong-Zhi\|Zhu, Shi-Tu\|Lu, Hang\|Niu, Zhe-Feng\|Guo, Wen-Feng\|Takano, Yasuo\|Zheng, Hua-Chuan
PMID:	23991985

226.
Journal:	APMIS. 2013 Oct;121(10):967-75.
Title:	Relationship of TGF-beta1 and Smad7 expression with decreased dendritic cell infiltration in liver gastrointestinal cancer metastasis.
Author:	Gulubova, Maya\|Manolova, Irena\|Ananiev, Julian\|Kjurkchiev, Dobroslav\|Julianov, Alexander\|Altunkova, Iskra
PMID:	23998914

227.
Journal:	Cancer Biol Ther. 2013 Nov;14(11):1059-67.
Title:	Targeting the ERK pathway reduces liver metastasis of Smad4-inactivated colorectal cancer.
Author:	Ai, Xi\|Wu, Yanhui\|Zhang, Wei\|Zhang, Zhanguo\|Jin, Guannan\|Zhao, Jianping\|Yu, Jingjing\|Lin, Youzhi\|Zhang, Wanguang\|Liang, Huifang\|Datta, Pran K\|Zhang, Mingzhi\|Zhang, Bixiang\|Chen, Xiaoping
PMID:	24025354

228.
Journal:	Cancer Cell Int. 2013 Oct 23;13(1):104.
Title:	Up-regulation of miR-224 promotes cancer cell proliferation and invasion and predicts relapse of colorectal cancer.
Author:	Zhang, Guang-Jun\|Zhou, He\|Xiao, Hua-Xu\|Li, Yu\|Zhou, Tong
PMID:	24152489

229.
Journal:	Gut Liver. 2013 Nov;7(6):747-51.
Title:	A novel germline mutation in exon 10 of the SMAD4 gene in a familial juvenile polyposis.
Author:	Jee, Myung Jin\|Yoon, Soon Man\|Kim, Eui Joong\|Choi, Hyun-Jung\|Kim, Jong-Won\|Sung, Ro Hyun\|Han, Joung Ho\|Chae, Hee Bok\|Park, Seon Mee\|Youn, Sei Jin
PMID:	24312718

230.
Journal:	Br J Cancer. 2014 Feb 18;110(4):946-57.
Title:	Loss of Smad4 in colorectal cancer induces resistance to 5-fluorouracil through activating Akt pathway.
Author:	Zhang, B\|Zhang, B\|Chen, X\|Bae, S\|Singh, K\|Washington, M K\|Datta, P K
PMID:	24384683

231.
Journal:	PLoS One. 2014 Jan 27;9(1):e82185.
Title:	An integrative CGH, MSI and candidate genes methylation analysis of colorectal tumors.
Author:	Brim, Hassan\|Abu-Asab, Mones S\|Nouraie, Mehdi\|Salazar, Jose\|Deleo, Jim\|Razjouyan, Hadi\|Mokarram, Pooneh\|Schaffer, Alejandro A\|Naghibhossaini, Fakhraddin\|Ashktorab, Hassan
PMID:	24475022

232.
Journal:	J Natl Cancer Inst. 2014 Apr;106(4):dju043.
Title:	Masking epistasis between MYC and TGF-beta pathways in antiangiogenesis-mediated colon cancer suppression.
Author:	Dews, Michael\|Tan, Grace S\|Hultine, Stacy\|Raman, Pichai\|Choi, Jaewoo\|Duperret, Elizabeth K\|Lawler, Jack\|Bass, Adam\|Thomas-Tikhonenko, Andrei
PMID:	24627270

233.
Journal:	Gastroenterology. 2014 Jul;147(1):196-208.e13.
Title:	Loss of SMAD4 alters BMP signaling to promote colorectal cancer cell metastasis via activation of Rho and ROCK.
Author:	Voorneveld, Philip W\|Kodach, Liudmila L\|Jacobs, Rutger J\|Liv, Nalan\|Zonnevylle, A Christiaan\|Hoogenboom, Jacob P\|Biemond, Izak\|Verspaget, Hein W\|Hommes, Daniel W\|de Rooij, Karien\|van Noesel, Carel J M\|Morreau, Hans\|van Wezel, Tom\|Offerhaus, G Johan A\|van
PMID:	24704720

234.
Journal:	Cancer Causes Control. 2014 Jun;25(6):759-69.
Title:	Colorectal cancer risk and patients' survival: influence of polymorphisms in genes somatically mutated in colorectal tumors.
Author:	Huhn, Stefanie\|Bevier, Melanie\|Pardini, Barbara\|Naccarati, Alessio\|Vodickova, Ludmila\|Novotny, Jan\|Vodicka, Pavel\|Hemminki, Kari\|Forsti, Asta
PMID:	24706189

235.
Journal:	Asian Pac J Cancer Prev. 2014;15(5):2083-7.
Title:	Loss of p15INK(4)b expression in colorectal cancer is linked to ethnic origin.
Author:	Abdel-Rahman, Wael Mohamed\|Nieminen, Taina Tuulikki\|Shoman, Soheir\|Eissa, Saad\|Peltomaki, Paivi
PMID:	24716938

236.
Journal:	Mol Med Rep. 2014 Jul;10(1):283-91.
Title:	miR20a is an independent prognostic factor in colorectal cancer and is involved in cell metastasis.
Author:	Zhang, Guang-Jun\|Li, Yu\|Zhou, He\|Xiao, Hua-Xu\|Zhou, Tong
PMID:	24737193

237.
Journal:	World J Gastroenterol. 2014 Apr 21;20(15):4230-43.
Title:	Molecular and prognostic heterogeneity of microsatellite-unstable colorectal cancer.
Author:	Kim, Jung Ho\|Kang, Gyeong Hoon
PMID:	24764661

238.
Journal:	Dis Markers. 2014;2014:617150.
Title:	MicroRNA-224 suppresses colorectal cancer cell migration by targeting Cdc42.
Author:	Ke, Tao-Wei\|Hsu, Han-Lin\|Wu, Yu-Hua\|Chen, William Tzu-Liang\|Cheng, Ya-Wen\|Cheng, Chao-Wen
PMID:	24817781

239.
Journal:	J Clin Invest. 2014 Jun;124(6):2472-82.
Title:	Synthetic triterpenoid induces 15-PGDH expression and suppresses inflammation-driven colon carcinogenesis.
Author:	Choi, Sung Hee\|Kim, Byung-Gyu\|Robinson, Janet\|Fink, Steve\|Yan, Min\|Sporn, Michael B\|Markowitz, Sanford D\|Letterio, John J
PMID:	24837432

240.
Journal:	Nat Med. 2014 Jul;20(7):769-77.
Title:	Oncogenic transformation of diverse gastrointestinal tissues in primary organoid culture.
Author:	Li, Xingnan\|Nadauld, Lincoln\|Ootani, Akifumi\|Corney, David C\|Pai, Reetesh K\|Gevaert, Olivier\|Cantrell, Michael A\|Rack, Paul G\|Neal, James T\|Chan, Carol W-M\|Yeung, Trevor\|Gong, Xue\|Yuan, Jenny\|Wilhelmy, Julie\|Robine, Sylvie\|Attardi, Laura D\|Plevritis, Sylv
PMID:	24859528

241.
Journal:	Biomed Res Int. 2014;2014:676724.
Title:	Multiple regression analysis of mRNA-miRNA associations in colorectal cancer pathway.
Author:	Wang, Fengfeng\|Wong, S C Cesar\|Chan, Lawrence W C\|Cho, William C S\|Yip, S P\|Yung, Benjamin Y M
PMID:	24895601

242.
Journal:	Oncol Rep. 2014 Sep;32(3):1124-32.
Title:	S-allylmercaptocysteine promotes MAPK inhibitor-induced apoptosis by activating the TGF-beta signaling pathway in cancer cells.
Author:	Tong, Dandan\|Qu, Hui\|Meng, Xiangning\|Jiang, Yang\|Liu, Duanyang\|Ye, Shengqian\|Chen, He\|Jin, Yan\|Fu, Songbin\|Geng, Jingshu
PMID:	24970681

243.
Journal:	Jpn J Clin Oncol. 2014 Oct;44(10):1004-8.
Title:	Identification of coding exon 3 duplication in the BMPR1A gene in a patient with juvenile polyposis syndrome.
Author:	Yamaguchi, Junya\|Nagayama, Satoshi\|Chino, Akiko\|Sakata, Ai\|Yamamoto, Noriko\|Sato, Yuri\|Ashihara, Yuumi\|Kita, Mizuho\|Nomura, Sachio\|Ishikawa, Yuichi\|Igarashi, Masahiro\|Ueno, Masashi\|Arai, Masami
PMID:	25129392

244.
Journal:	PLoS One. 2014 Oct 15;9(10):e110182.
Title:	Meta-analysis of the prognostic value of smad4 immunohistochemistry in various cancers.
Author:	Du, Yiping\|Zhou, Xin\|Huang, Zebo\|Qiu, Tianzhu\|Wang, Jian\|Zhu, Wei\|Wang, Tongshan\|Liu, Ping
PMID:	25333693

245.
Journal:	Ugeskr Laeger. 2014 Oct 27;176(44).
Title:	[Juvenile polyposis syndrome and hereditary haemorrhagic telangiectasia syndrome in a patient a with SMAD4 mutation].
Author:	Jelsig, Anne Marie\|Torring, Pernille Mathiesen\|Wikman, Friedrik\|Mortensen, Michael Bau\|Qvist, Niels\|Ousager, Lilian Bomme
PMID:	25354002

246.
Journal:	Chin J Cancer Res. 2014 Oct;26(5):525-31.
Title:	Deletion and down-regulation of SMAD4 gene in colorectal cancers in a Chinese population.
Author:	Ma, Yanling\|Yan, Fei\|Li, Li\|Liu, Li\|Sun, Jianhai
PMID:	25400417

247.
Journal:	J Eur Acad Dermatol Venereol. 2015 Nov;29(11):2265-7.
Title:	TGFbeta/SMAD4 signalling is inhibited in tumour cells and infiltrating lymphocytes of a patient with colon cancer-associated dermatomyositis.
Author:	Kasuya, A\|Hoshino, T\|Aoshima, M\|Tatsuno, K\|Fujiyama, T\|Tokura, Y
PMID:	24862343

248.
Journal:	Gut. 2015 Apr;64(4):636-45.
Title:	Novel recurrently mutated genes and a prognostic mutation signature in colorectal cancer.
Author:	Yu, Jun\|Wu, William K K\|Li, Xiangchun\|He, Jun\|Li, Xiao-Xing\|Ng, Simon S M\|Yu, Chang\|Gao, Zhibo\|Yang, Jie\|Li, Miao\|Wang, Qiaoxiu\|Liang, Qiaoyi\|Pan, Yi\|Tong, Joanna H\|To, Ka F\|Wong, Nathalie\|Zhang, Ning\|Chen, Jie\|Lu, Youyong\|Lai, Paul B S\|Chan, Francis K L\|
PMID:	24951259

249.
Journal:	Clin Transl Oncol. 2015 Feb;17(2):133-8.
Title:	SMAD4 and TS expression might predict the risk of recurrence after resection of colorectal liver metastases.
Author:	Lopez-Gomez, M\|Moreno-Rubio, J\|Suarez-Garcia, I\|Cejas, P\|Madero, R\|Casado, E\|Jimenez, A\|Sereno, M\|Gomez-Raposo, C\|Zambrana, F\|Merino, M\|Fernandez-Luengas, D\|Feliu, J
PMID:	25060566

250.
Journal:	Clin Transl Oncol. 2015 Apr;17(4):322-9.
Title:	Gene expression differences in primary colorectal tumors and matched liver metastases: chemotherapy related or tumoral heterogeneity?
Author:	Lopez-Gomez, M\|Moreno-Rubio, J\|Suarez-Garcia, I\|Cejas, P\|Madero, R\|Casado, E\|Jimenez, A M\|Sereno, M\|Gomez-Raposo, C\|Zambrana, F\|Merino, M\|Fernandez-Luengas, D\|Feliu, J
PMID:	25301403

251.
Journal:	Oncol Rep. 2015 Jan;33(1):185-92.
Title:	Effect of Smad3/4 on chemotherapeutic drug sensitivity in colorectal cancer cells.
Author:	Moon, Sung Ung\|Kang, Mi Hyun\|Sung, Ji Hea\|Kim, Jin Won\|Lee, Jeong Ok\|Kim, Yu Jung\|Lee, Keun Wook\|Bang, Soo Mee\|Lee, Jong Seok\|Kim, Jee Hyun
PMID:	25370208

252.
Journal:	Br J Cancer. 2015 Jan 6;112(1):122-30.
Title:	The BMP pathway either enhances or inhibits the Wnt pathway depending on the SMAD4 and p53 status in CRC.
Author:	Voorneveld, P W\|Kodach, L L\|Jacobs, R J\|van Noesel, C J M\|Peppelenbosch, M P\|Korkmaz, K S\|Molendijk, I\|Dekker, E\|Morreau, H\|van Pelt, G W\|Tollenaar, R A E M\|Mesker, W\|Hawinkels, L J A C\|Paauwe, M\|Verspaget, H W\|Geraets, D T\|Hommes, D W\|Offerhaus, G J A\|va
PMID:	25393365

253.
Journal:	Int J Oncol. 2015 Feb;46(2):685-90.
Title:	Pien Tze Huang inhibits metastasis of human colorectal carcinoma cells via modulation of TGF-beta1/ZEB/miR-200 signaling network.
Author:	Shen, Aling\|Lin, Wei\|Chen, Youqin\|Liu, Liya\|Chen, Hongwei\|Zhuang, Qunchuan\|Lin, Jiumao\|Sferra, Thomas J\|Peng, Jun
PMID:	25422078

254.
Journal:	J Clin Oncol. 2015 Feb 10;33(5):426-32.
Title:	Genetic diagnosis of high-penetrance susceptibility for colorectal cancer (CRC) is achievable for a high proportion of familial CRC by exome sequencing.
Author:	Chubb, Daniel\|Broderick, Peter\|Frampton, Matthew\|Kinnersley, Ben\|Sherborne, Amy\|Penegar, Steven\|Lloyd, Amy\|Ma, Yussanne P\|Dobbins, Sara E\|Houlston, Richard S
PMID:	25559809

255.
Journal:	PLoS One. 2015 Jan 24;10(1):e0116753.
Title:	A pathway-centric survey of somatic mutations in Chinese patients with colorectal carcinomas.
Author:	Ling, Chao\|Wang, Lin\|Wang, Zheng\|Xu, Luming\|Sun, Lifang\|Yang, Hui\|Li, Wei-Dong\|Wang, Kai
PMID:	25617745

256.
Journal:	Biochem Biophys Res Commun. 2015 Feb 27;458(1):52-6.
Title:	Inter- and intra-tumor profiling of multi-regional colon cancer and metastasis.
Author:	Kogita, Akihiro\|Yoshioka, Yasumasa\|Sakai, Kazuko\|Togashi, Yosuke\|Sogabe, Shunsuke\|Nakai, Takuya\|Okuno, Kiyotaka\|Nishio, Kazuto
PMID:	25623536

257.
Journal:	Oncol Rep. 2015 Apr;33(4):1922-8.
Title:	Pien Tze Huang inhibits liver metastasis by targeting TGF-beta signaling in an orthotopic model of colorectal cancer.
Author:	Lin, Wei\|Zhuang, Qunchuan\|Zheng, Liangpu\|Cao, Zhiyun\|Shen, Aling\|Li, Qiongyu\|Fu, Caixuan\|Feng, Jianyu\|Peng, Jun
PMID:	25653118

258.
Journal:	Pathol Res Pract. 2015 Apr;211(4):286-92.
Title:	Smad4 acts as tumor suppressor by antagonizing lymphangiogenesis in colorectal cancer.
Author:	Liu, Yanqing\|Sheng, Jizhang\|Dai, Dianlu\|Liu, Tong\|Qi, Feng
PMID:	25680269

259.
Journal:	J Clin Pathol. 2015 May;68(5):341-5.
Title:	Smad4 inactivation predicts for worse prognosis and response to fluorouracil-based treatment in colorectal cancer.
Author:	Kozak, Margaret M\|von Eyben, Rie\|Pai, Jonathan\|Vossler, Stephen R\|Limaye, Maneesha\|Jayachandran, Priya\|Anderson, Eric M\|Shaffer, Jenny L\|Longacre, Teri\|Pai, Reetesh K\|Koong, Albert C\|Chang, Daniel T
PMID:	25681512

260.
Journal:	Mol Med Rep. 2015 Jul;12(1):192-8.
Title:	Chemoresistance to doxorubicin induces epithelial-mesenchymal transition via upregulation of transforming growth factor beta signaling in HCT116 colon cancer cells.
Author:	Li, Jinpeng\|Liu, Hao\|Yu, Jieping\|Yu, Honggang
PMID:	25684678

261.
Journal:	Clin Cancer Res. 2015 Jun 1;21(11):2644-51.
Title:	Hotspot mutation panel testing reveals clonal evolution in a study of 265 paired primary and metastatic tumors.
Author:	Goswami, Rashmi S\|Patel, Keyur P\|Singh, Rajesh R\|Meric-Bernstam, Funda\|Kopetz, E Scott\|Subbiah, Vivek\|Alvarez, Ricardo H\|Davies, Michael A\|Jabbar, Kausar J\|Roy-Chowdhuri, Sinchita\|Lazar, Alexander J\|Medeiros, L Jeffrey\|Broaddus, Russell R\|Luthra, Rajyalak
PMID:	25695693

262.
Journal:	Nat Med. 2015 Mar;21(3):256-62.
Title:	Modeling colorectal cancer using CRISPR-Cas9-mediated engineering of human intestinal organoids.
Author:	Matano, Mami\|Date, Shoichi\|Shimokawa, Mariko\|Takano, Ai\|Fujii, Masayuki\|Ohta, Yuki\|Watanabe, Toshiaki\|Kanai, Takanori\|Sato, Toshiro
PMID:	25706875

263.
Journal:	Exp Mol Pathol. 2015 Apr;98(2):133-5.
Title:	Mononucleotide repeats in the SMAD4 gene promoter in colon carcinoma tissue of Croatian patients.
Author:	Nikolic, Aleksandra\|Cacev, Tamara\|Aralica, Gorana\|Popovic Hadzija, Marijana\|Kapitanovic, Sanja\|Radojkovic, Dragica
PMID:	25742737

264.
Journal:	Transl Oncol. 2015 Feb;8(1):18-24.
Title:	A Meta-Analysis of SMAD4 Immunohistochemistry as a Prognostic Marker in Colorectal Cancer.
Author:	Voorneveld, Philip W\|Jacobs, Rutger J\|Kodach, Liudmila L\|Hardwick, James C H
PMID:	25749173

265.
Journal:	Am J Surg Pathol. 2015 Aug;39(8):1140-7.
Title:	Distinctive Spatiotemporal Stability of Somatic Mutations in Metastasized Microsatellite-stable Colorectal Cancer.
Author:	Jesinghaus, Moritz\|Wolf, Thomas\|Pfarr, Nicole\|Muckenhuber, Alexander\|Ahadova, Aysel\|Warth, Arne\|Goeppert, Benjamin\|Sers, Christine\|Kloor, Matthias\|Endris, Volker\|Stenzinger, Albrecht\|Weichert, Wilko
PMID:	25786087

266.
Journal:	Nature. 2015 May 7;521(7550):43-7.
Title:	Sequential cancer mutations in cultured human intestinal stem cells.
Author:	Drost, Jarno\|van Jaarsveld, Richard H\|Ponsioen, Bas\|Zimberlin, Cheryl\|van Boxtel, Ruben\|Buijs, Arjan\|Sachs, Norman\|Overmeer, Rene M\|Offerhaus, G Johan\|Begthel, Harry\|Korving, Jeroen\|van de Wetering, Marc\|Schwank, Gerald\|Logtenberg, Meike\|Cuppen, Edwin\|Sni
PMID:	25924068

267.
Journal:	J Mol Biol. 2015 Oct 23;427(21):3407-15.
Title:	Crosstalk between Hippo and TGFbeta: Subcellular Localization of YAP/TAZ/Smad Complexes.
Author:	Grannas, Karin\|Arngarden, Linda\|Lonn, Peter\|Mazurkiewicz, Magdalena\|Blokzijl, Andries\|Zieba, Agata\|Soderberg, Ola
PMID:	25937570

268.
Journal:	PLoS One. 2015 May 14;10(5):e0126670.
Title:	Co-evolution of somatic variation in primary and metastatic colorectal cancer may expand biopsy indications in the molecular era.
Author:	Kim, Richard\|Schell, Michael J\|Teer, Jamie K\|Greenawalt, Danielle M\|Yang, Mingli\|Yeatman, Timothy J
PMID:	25974029

269.
Journal:	PLoS One. 2015 Jun 22;10(6):e0131108.
Title:	A Transition Zone Showing Highly Discontinuous or Alternating Levels of Stem Cell and Proliferation Markers Characterizes the Development of PTEN-Haploinsufficient Colorectal Cancer.
Author:	Arvai, Kevin J\|Hsu, Ya-Hsuan\|Lee, Lobin A\|Jones, Dan
PMID:	26098881

270.
Journal:	Br J Cancer. 2015 Jun 30;113(1):1-5.
Title:	Stem vs non-stem cell origin of colorectal cancer.
Author:	Huels, D J\|Sansom, O J
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271.
Journal:	J Hum Genet. 2015 Oct;60(10):589-96.
Title:	Genetic mutations in human rectal cancers detected by targeted sequencing.
Author:	Bai, Jun\|Gao, Jinglong\|Mao, Zhijun\|Wang, Jianhua\|Li, Jianhui\|Li, Wensheng\|Lei, Yu\|Li, Shuaishuai\|Wu, Zhuo\|Tang, Chuanning\|Jones, Lindsey\|Ye, Hua\|Lou, Feng\|Liu, Zhiyuan\|Dong, Zhishou\|Guo, Baishuai\|Huang, Xue F\|Chen, Si-Yi\|Zhang, Enke
PMID:	26134512

272.
Journal:	Ann Clin Biochem. 2015 Nov;52(Pt 6):690-2.
Title:	The Mendelian colorectal cancer syndromes.
Author:	Tomlinson, Ian
PMID:	26169059

273.
Journal:	J Exp Clin Cancer Res. 2015 Jul 25;34:71.
Title:	Vitamin D3 enhances the tumouricidal effects of 5-Fluorouracil through multipathway mechanisms in azoxymethane rat model of colon cancer.
Author:	Refaat, Bassem\|El-Shemi, Adel Galal\|Kensara, Osama Adnan\|Mohamed, Amr Mohamed\|Idris, Shakir\|Ahmad, Jawwad\|Khojah, Athar
PMID:	26205949

274.
Journal:	Int J Clin Exp Pathol. 2015 Jun 1;8(6):7112-21. eCollection 2015.
Title:	High expression of COUP-TF II cooperated with negative Smad4 expression predicts poor prognosis in patients with colorectal cancer.
Author:	Wang, Chaoqun\|Zhou, Yun\|Ruan, Ruoyun\|Zheng, Maojin\|Han, Wencan\|Liao, Linchuan
PMID:	26261604

275.
Journal:	Gastroenterol Hepatol Bed Bench. 2015 Summer;8(3):215-24.
Title:	Protein-Protein Interaction Network could reveal the relationship between the breast and colon cancer.
Author:	Zamanian-Azodi, Mona\|Rezaei-Tavirani, Mostafa\|Rahmati-Rad, Sara\|Hasanzadeh, Hadi\|Rezaei Tavirani, Majid\|Seyyedi, Samaneh Sadat
PMID:	26328044

276.
Journal:	PLoS One. 2015 Sep 16;10(9):e0138141.
Title:	High Prevalence and Clinical Relevance of Genes Affected by Chromosomal Breaks in Colorectal Cancer.
Author:	van den Broek, Evert\|Dijkstra, Maurits J J\|Krijgsman, Oscar\|Sie, Daoud\|Haan, Josien C\|Traets, Joleen J H\|van de Wiel, Mark A\|Nagtegaal, Iris D\|Punt, Cornelis J A\|Carvalho, Beatriz\|Ylstra, Bauke\|Abeln, Sanne\|Meijer, Gerrit A\|Fijneman, Remond J A
PMID:	26375816

277.
Journal:	Cancer. 2015 Dec 15;121(24):4359-68.
Title:	Clinicopathological and genetic differences between low-grade and high-grade colorectal mucinous adenocarcinomas.
Author:	Yoshioka, Yasumasa\|Togashi, Yosuke\|Chikugo, Takaaki\|Kogita, Akihiro\|Taguri, Masataka\|Terashima, Masato\|Mizukami, Takuro\|Hayashi, Hidetoshi\|Sakai, Kazuko\|de Velasco, Marco A\|Tomida, Shuta\|Fujita, Yoshihiko\|Tokoro, Tadao\|Ito, Akihiko\|Okuno, Kiyotaka\|Nishio,
PMID:	26488212

278.
Journal:	Mol Cancer. 2015 Oct 24;14:182.
Title:	Activin and TGFbeta use diverging mitogenic signaling in advanced colon cancer.
Author:	Bauer, Jessica\|Ozden, Ozkan\|Akagi, Naomi\|Carroll, Timothy\|Principe, Daniel R\|Staudacher, Jonas J\|Spehlmann, Martina E\|Eckmann, Lars\|Grippo, Paul J\|Jung, Barbara
PMID:	26497569

279.
Journal:	BMC Cancer. 2015 Oct 27;15:808.
Title:	Prediction of response to anti-EGFR antibody-based therapies by multigene sequencing in colorectal cancer patients.
Author:	Lupini, Laura\|Bassi, Cristian\|Mlcochova, Jitka\|Musa, Gentian\|Russo, Marta\|Vychytilova-Faltejskova, Petra\|Svoboda, Marek\|Sabbioni, Silvia\|Nemecek, Radim\|Slaby, Ondrej\|Negrini, Massimo
PMID:	26508446

280.
Journal:	Int J Clin Exp Med. 2015 Oct 15;8(10):19662-9. eCollection 2015.
Title:	Halichondrin B amide acts as tubulin binding agent to exhibit anti-tumor efficacy in hematologic cancers.
Author:	Li, Ying-Chun\|Zhang, Rong\|Yang, Ying\|Li, Jia\|Zhu, Ke\|Yao, Kun\|Liu, Zhuo-Gang
PMID:	26770630

281.
Journal:	Gut. 2016 Jun;65(6):977-989.
Title:	The clinical and biological significance of MIR-224 expression in colorectal cancer metastasis.
Author:	Ling, Hui\|Pickard, Karen\|Ivan, Cristina\|Isella, Claudio\|Ikuo, Mariko\|Mitter, Richard\|Spizzo, Riccardo\|Bullock, Marc\|Braicu, Cornelia\|Pileczki, Valentina\|Vincent, Kimberly\|Pichler, Martin\|Stiegelbauer, Verena\|Hoefler, Gerald\|Almeida, Maria I\|Hsiao, Annie\|Z
PMID:	25804630

282.
Journal:	Oncogene. 2016 Feb 4;35(5):577-586.
Title:	Smad4 loss promotes lung cancer formation but increases sensitivity to DNA topoisomerase inhibitors.
Author:	Haeger, Sarah M\|Thompson, Joshua J\|Kalra, Sean\|Cleaver, Timothy G\|Merrick, Daniel\|Wang, Xiao-Jing\|Malkoski, Stephen P
PMID:	25893305

283.
Journal:	Clin Cancer Res. 2016 Jan 15;22(2):492-501.
Title:	Loss of SMAD4 Promotes Colorectal Cancer Progression by Accumulation of Myeloid-Derived Suppressor Cells through the CCL15-CCR1 Chemokine Axis.
Author:	Inamoto, Susumu\|Itatani, Yoshiro\|Yamamoto, Takamasa\|Minamiguchi, Sachiko\|Hirai, Hideyo\|Iwamoto, Masayoshi\|Hasegawa, Suguru\|Taketo, Makoto Mark\|Sakai, Yoshiharu\|Kawada, Kenji
PMID:	26341919

284.
Journal:	Acta Biochim Biophys Sin (Shanghai). 2016 Jan;48(1):27-38.
Title:	RAS signaling and anti-RAS therapy: lessons learned from genetically engineered mouse models, human cancer cells, and patient-related studies.
Author:	Fang, Bingliang
PMID:	26350096

285.
Journal:	Ann Surg Oncol. 2016 Mar;23(3):849-55.
Title:	Mutation Spectra of Common Cancer-Associated Genes in Different Phenotypes of Colorectal Carcinoma Without Distant Metastasis.
Author:	Chang, Shih-Ching\|Lin, Pei-Ching\|Lin, Jen-Kou\|Lin, Chien-Hsing\|Yang, Shung-Haur\|Liang, Wen-Yi\|Chen, Wei-Shone\|Jiang, Jeng-Kai
PMID:	26471487

286.
Journal:	Arch Pathol Lab Med. 2016 Jun;140(6):529-35.
Title:	Next-Generation Sequencing of Matched Primary and Metastatic Rectal Adenocarcinomas Demonstrates Minimal Mutation Gain and Concordance to Colonic Adenocarcinomas.
Author:	Crumley, Suzanne M\|Pepper, Kristi L\|Phan, Alexandria T\|Olsen, Randall J\|Schwartz, Mary R\|Portier, Bryce P
PMID:	26536055

287.
Journal:	Oncol Rep. 2016 Mar;35(3):1807-15.
Title:	Smad4 sensitizes colorectal cancer to 5-fluorouracil through cell cycle arrest by inhibiting the PI3K/Akt/CDC2/survivin cascade.
Author:	Zhang, Binhao\|Leng, Chao\|Wu, Chao\|Zhang, Zhanguo\|Dou, Lei\|Luo, Xin\|Zhang, Bixiang\|Chen, Xiaoping
PMID:	26647806

288.
Journal:	J Clin Pathol. 2016 Sep;69(9):767-71.
Title:	Less frequently mutated genes in colorectal cancer: evidences from next-generation sequencing of 653 routine cases.
Author:	Malapelle, Umberto\|Pisapia, Pasquale\|Sgariglia, Roberta\|Vigliar, Elena\|Biglietto, Maria\|Carlomagno, Chiara\|Giuffre, Giuseppe\|Bellevicine, Claudio\|Troncone, Giancarlo
PMID:	26797410

289.
Journal:	Clin Cancer Res. 2016 Jun 15;22(12):3037-47.
Title:	Reduced Expression of SMAD4 Is Associated with Poor Survival in Colon Cancer.
Author:	Yan, Pu\|Klingbiel, Dirk\|Saridaki, Zenia\|Ceppa, Paola\|Curto, Monica\|McKee, Thomas Alexander\|Roth, Arnaud\|Tejpar, Sabine\|Delorenzi, Mauro\|Bosman, Fredrik T\|Fiocca, Roberto
PMID:	26861460

290.
Journal:	World J Gastroenterol. 2016 Feb 21;22(7):2314-25.
Title:	Mutation analysis of 13 driver genes of colorectal cancer-related pathways in Taiwanese patients.
Author:	Chang, Yuli Christine\|Chang, Jan-Gowth\|Liu, Ta-Chih\|Lin, Chien-Yu\|Yang, Shu-Fen\|Ho, Cheng-Mao\|Chen, William Tzu-Liang\|Chang, Ya-Sian
PMID:	26900293

291.
Journal:	Cancer. 2016 Jun 1;122(11):1689-96.
Title:	Whole-exome sequencing of duodenal adenocarcinoma identifies recurrent Wnt/beta-catenin signaling pathway mutations.
Author:	Yuan, Wei\|Zhang, Zhou\|Dai, Binghua\|Wei, Qing\|Liu, Jinjin\|Liu, Yuzhen\|Liu, Yun\|He, Lin\|Zhou, Daizhan
PMID:	26998897

292.
Journal:	PLoS One. 2016 Mar 29;11(3):e0152673.
Title:	Colorectal Cancer Genetic Heterogeneity Delineated by Multi-Region Sequencing.
Author:	Lu, You-Wang\|Zhang, Hui-Feng\|Liang, Rui\|Xie, Zhen-Rong\|Luo, Hua-You\|Zeng, Yu-Jian\|Xu, Yu\|Wang, La-Mei\|Kong, Xiang-Yang\|Wang, Kun-Hua
PMID:	27023146

293.
Journal:	J Transl Med. 2016 May 4;14(1):118.
Title:	Clinical significance of frequent somatic mutations detected by high-throughput targeted sequencing in archived colorectal cancer samples.
Author:	Dallol, Ashraf\|Buhmeida, Abdelbaset\|Al-Ahwal, Mahmoud Shaheen\|Al-Maghrabi, Jaudah\|Bajouh, Osama\|Al-Khayyat, Shadi\|Alam, Rania\|Abusanad, Atlal\|Turki, Rola\|Elaimi, Aisha\|Alhadrami, Hani A\|Abuzenadah, Mohammed\|Banni, Huda\|Al-Qahtani, Mohammed H\|Abuzenadah, A
PMID:	27146902

294.
Journal:	J Mol Diagn. 2016 Jul;18(4):471-9.
Title:	Driver Gene Mutations in Stools of Colorectal Carcinoma Patients Detected by Targeted Next-Generation Sequencing.
Author:	Armengol, Gemma\|Sarhadi, Virinder K\|Ghanbari, Reza\|Doghaei-Moghaddam, Masoud\|Ansari, Reza\|Sotoudeh, Masoud\|Puolakkainen, Pauli\|Kokkola, Arto\|Malekzadeh, Reza\|Knuutila, Sakari
PMID:	27155048

295.
Journal:	Oncotarget. 2016 Jul 19;7(29):45199-45213.
Title:	MicroRNA-20a-5p promotes colorectal cancer invasion and metastasis by downregulating Smad4.
Author:	Cheng, Dantong\|Zhao, Senlin\|Tang, Huamei\|Zhang, Dongyuan\|Sun, Hongcheng\|Yu, Fudong\|Jiang, Weiliang\|Yue, Ben\|Wang, Jingtao\|Zhang, Meng\|Yu, Yang\|Liu, Xisheng\|Sun, Xiaofeng\|Zhou, Zongguang\|Qin, Xuebin\|Zhang, Xin\|Yan, Dongwang\|Wen, Yugang\|Peng, Zhihai
PMID:	27286257

296.
Journal:	Virchows Arch. 2016 Aug;469(2):125-34.
Title:	Molecular pathological classification of colorectal cancer.
Author:	Muller, Mike F\|Ibrahim, Ashraf E K\|Arends, Mark J
PMID:	27325016

297.
Journal:	Drug Des Devel Ther. 2016 Jul 11;10:2239-53.
Title:	Thymoquinone subdues tumor growth and potentiates the chemopreventive effect of 5-fluorouracil on the early stages of colorectal carcinogenesis in rats.
Author:	Kensara, Osama Adnan\|El-Shemi, Adel Galal\|Mohamed, Amr Mohamed\|Refaat, Bassem\|Idris, Shakir\|Ahmad, Jawwad
PMID:	27468227

298.
Journal:	Oncotarget. 2016 Sep 20;7(38):61562-61574.
Title:	Pregnancy-specific glycoprotein 9 (PSG9), a driver for colorectal cancer, enhances angiogenesis via activation of SMAD4.
Author:	Yang, Lei\|Hu, Shusheng\|Tan, Jinjing\|Zhang, Xiaojing\|Yuan, Wen\|Wang, Qian\|Xu, Lingling\|Liu, Jian\|Liu, Zheng\|Jia, Yanjun\|Huang, Xiaoxi
PMID:	27528036

299.
Journal:	Med Oncol. 2016 Oct;33(10):106.
Title:	Targeted molecular profiling of rare genetic alterations in colorectal cancer using next-generation sequencing.
Author:	Jauhri, Mayank\|Bhatnagar, Akanksha\|Gupta, Satish\|Shokeen, Yogender\|Minhas, Sachin\|Aggarwal, Shyam
PMID:	27568332

300.
Journal:	World J Gastroenterol. 2016 Aug 21;22(31):7099-110.
Title:	Current understanding concerning intestinal stem cells.
Author:	Cui, Shuang\|Chang, Peng-Yu
PMID:	27610020

301.
Journal:	Oncotarget. 2016 Oct 11;7(41):67196-67211.
Title:	TGF-beta1 promotes colorectal cancer immune escape by elevating B7-H3 and B7-H4 via the miR-155/miR-143 axis.
Author:	Zhou, Xinru\|Mao, Yong\|Zhu, Jianjie\|Meng, Fanyi\|Chen, Qi\|Tao, Lihua\|Li, Rui\|Fu, Fengqing\|Liu, Cuiping\|Hu, Yuanjia\|Wang, Weipeng\|Zhang, Hongjian\|Hua, Dong\|Chen, Weichang\|Zhang, Xueguang
PMID:	27626488

302.
Journal:	Oncotarget. 2016 Nov 8;7(45):72908-72922.
Title:	Genomic characterization of liver metastases from colorectal cancer patients.
Author:	Sayagues, Jose Maria\|Corchete, Luis Antonio\|Gutierrez, Maria Laura\|Sarasquete, Maria Eugenia\|Del Mar Abad, Maria\|Bengoechea, Oscar\|Ferminan, Encarna\|Anduaga, Maria Fernanda\|Del Carmen, Sofia\|Iglesias, Manuel\|Esteban, Carmen\|Angoso, Maria\|Alcazar, Jose Ant
PMID:	27662660

303.
Journal:	Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):11859-11864.
Title:	Generation of an inducible colon-specific Cre enzyme mouse line for colon cancer research.
Author:	Tetteh, Paul W\|Kretzschmar, Kai\|Begthel, Harry\|van den Born, Maaike\|Korving, Jeroen\|Morsink, Folkert\|Farin, Henner\|van Es, Johan H\|Offerhaus, G Johan A\|Clevers, Hans
PMID:	27708166

304.
Journal:	Oncotarget. 2016 Nov 8;7(45):73876-73887.
Title:	Genomic profiling of stage II and III colon cancers reveals APC mutations to be associated with survival in stage III colon cancer patients.
Author:	van den Broek, Evert\|Krijgsman, Oscar\|Sie, Daoud\|Tijssen, Marianne\|Mongera, Sandra\|van de Wiel, Mark A\|Belt, Eric J Th\|den Uil, Sjoerd H\|Bril, Herman\|Stockmann, Hein B A C\|Ylstra, Bauke\|Carvalho, Beatriz\|Meijer, Gerrit A\|Fijneman, Remond J A
PMID:	27729614

305.
Journal:	J Gastrointest Surg. 2016 Dec;20(12):2074-2082.
Title:	Expression of VEGF-D, SMAD4, and SMAD7 and Their Relationship with Lymphangiogenesis and Prognosis in Colon Cancer.
Author:	Su, Fei\|Li, Xuemei\|You, Kai\|Chen, Mingwei\|Xiao, Jianbing\|Zhang, Yafang\|Ma, Jing\|Liu, Baoquan
PMID:	27730400

306.
Journal:	Eur J Cancer. 2016 Nov;68:114-124.
Title:	The role of S100a4 (Mts1) in Apc- and Smad4-driven tumour onset and progression.
Author:	Atlasi, Yaser\|Noori, Rubina\|Marolin, Ivana\|Franken, Patrick\|Brandao, Joana\|Biermann, Katharina\|Collini, Paola\|Grigorian, Mariam\|Lukanidin, Eugene\|Ambartsumian, Noona\|Fodde, Riccardo
PMID:	27750112

307.
Journal:	Mol Cancer. 2016 Oct 18;15(1):63.
Title:	Spatio-temporal mutation profiles of case-matched colorectal carcinomas and their metastases reveal unique de novo mutations in metachronous lung metastases by targeted next generation sequencing.
Author:	Kovaleva, Valentina\|Geissler, Anna-Lena\|Lutz, Lisa\|Fritsch, Ralph\|Makowiec, Frank\|Wiesemann, Sebastian\|Hopt, Ulrich T\|Passlick, Bernward\|Werner, Martin\|Lassmann, Silke
PMID:	27756406

308.
Journal:	Transl Oncol. 2016 Dec;9(6):512-520.
Title:	SDHB deficiency promotes TGFbeta-mediated invasion and metastasis of colorectal cancer through transcriptional repression complex SNAIL1-SMAD3/4.
Author:	Wang, Haiyu\|Chen, Yusheng\|Wu, Guohao
PMID:	27816688

309.
Journal:	J Gastrointest Oncol. 2016 Dec;7(6):882-902.
Title:	Molecular spectrum of KRAS, NRAS, BRAF, PIK3CA, TP53, and APC somatic gene mutations in Arab patients with colorectal cancer: determination of frequency and distribution pattern.
Author:	Al-Shamsi, Humaid O\|Jones, Jeremy\|Fahmawi, Yazan\|Dahbour, Ibrahim\|Tabash, Aziz\|Abdel-Wahab, Reham\|Abousamra, Ahmed O S\|Shaw, Kenna R\|Xiao, Lianchun\|Hassan, Manal M\|Kipp, Benjamin R\|Kopetz, Scott\|Soliman, Amr S\|McWilliams, Robert R\|Wolff, Robert A
PMID:	28078112

310.
Journal:	Oncol Lett. 2016 Dec;12(6):4773-4778.
Title:	Impact of chromosome 17q deletion in the primary lesion of colorectal cancer on liver metastasis.
Author:	Kawai, Masaya\|Komiyama, Hiromitsu\|Hosoya, Masaki\|Okubo, Haruna\|Fujii, Tomoaki\|Yokoyama, Norihiko\|Sato, Chiyo\|Ueyama, Takae\|Okuzawa, Atsushi\|Goto, Michitoshi\|Kojima, Yutaka\|Takahashi, Makoto\|Sugimoto, Kiichi\|Ishiyama, Shun\|Munakata, Shinya\|Ogura, Dai\|Niwa,
PMID:	28101224

311.
Journal:	Neuroendocrinology. 2017;104(3):302-312.
Title:	Loss of Chromosome 18 in Neuroendocrine Tumors of the Small Intestine: The Enigma Remains.
Author:	Nieser, Maike\|Henopp, Tobias\|Brix, Joachim\|Stoss, Laura\|Sitek, Barbara\|Naboulsi, Wael\|Anlauf, Martin\|Schlitter, Anna M\|Kloppel, Gunter\|Gress, Thomas\|Moll, Roland\|Bartsch, Detlef K\|Heverhagen, Anna E\|Knoefel, Wolfram T\|Kaemmerer, Daniel\|Haybaeck, Johannes\|
PMID:	27222126

312.
Journal:	Clin Cancer Res. 2017 Feb 1;23(3):833-844.
Title:	Loss of SMAD4 Promotes Lung Metastasis of Colorectal Cancer by Accumulation of CCR1+ Tumor-Associated Neutrophils through CCL15-CCR1 Axis.
Author:	Yamamoto, Takamasa\|Kawada, Kenji\|Itatani, Yoshiro\|Inamoto, Susumu\|Okamura, Ryosuke\|Iwamoto, Masayoshi\|Miyamoto, Ei\|Chen-Yoshikawa, Toyofumi F\|Hirai, Hideyo\|Hasegawa, Suguru\|Date, Hiroshi\|Taketo, Makoto M\|Sakai, Yoshiharu
PMID:	27492974

313.
Journal:	Fam Cancer. 2017 Apr;16(2):195-203.
Title:	Expanding the genotype-phenotype spectrum in hereditary colorectal cancer by gene panel testing.
Author:	Rohlin, Anna\|Rambech, Eva\|Kvist, Anders\|Torngren, Therese\|Eiengard, Frida\|Lundstam, Ulf\|Zagoras, Theofanis\|Gebre-Medhin, Samuel\|Borg, Ake\|Bjork, Jan\|Nilbert, Mef\|Nordling, Margareta
PMID:	27696107

314.
Journal:	Cancer. 2017 Apr 1;123(7):1134-1143.
Title:	Clinical and genetic determinants of ovarian metastases from colorectal cancer.
Author:	Ganesh, Karuna\|Shah, Ronak H\|Vakiani, Efsevia\|Nash, Garrett M\|Skottowe, Hugh P\|Yaeger, Rona\|Cercek, Andrea\|Lincoln, Anne\|Tran, Christina\|Segal, Neil H\|Reidy, Diane L\|Varghese, Anna\|Epstein, Andrew S\|Sonoda, Yukio\|Chi, Dennis\|Guillem, Jose\|Temple, Larissa\|
PMID:	27875625

315.
Journal:	Oncol Rep. 2017 Feb;37(2):747-753.
Title:	Oxymatrine inhibits the migration of human colorectal carcinoma RKO cells via inhibition of PAI-1 and the TGF-beta1/Smad signaling pathway.
Author:	Wang, Xiaoyu\|Liu, Chun\|Wang, Jiaqi\|Fan, Yue\|Wang, Zhenghua\|Wang, Yuanyuan
PMID:	27959430

316.
Journal:	JAMA Oncol. 2017 Apr 1;3(4):464-471.
Title:	Prevalence and Spectrum of Germline Cancer Susceptibility Gene Mutations Among Patients With Early-Onset Colorectal Cancer.
Author:	Pearlman, Rachel\|Frankel, Wendy L\|Swanson, Benjamin\|Zhao, Weiqiang\|Yilmaz, Ahmet\|Miller, Kristin\|Bacher, Jason\|Bigley, Christopher\|Nelsen, Lori\|Goodfellow, Paul J\|Goldberg, Richard M\|Paskett, Electra\|Shields, Peter G\|Freudenheim, Jo L\|Stanich, Peter P\|Lat
PMID:	27978560

317.
Journal:	Oncotarget. 2017 Jan 31;8(5):7852-7866.
Title:	Targeted exome sequencing reveals distinct pathogenic variants in Iranians with colorectal cancer.
Author:	Ashktorab, Hassan\|Mokarram, Pooneh\|Azimi, Hamed\|Olumi, Hasti\|Varma, Sudhir\|Nickerson, Michael L\|Brim, Hassan
PMID:	28002797

318.
Journal:	Int J Mol Sci. 2017 Jan 19;18(1). pii: ijms18010197.
Title:	Colorectal Carcinoma: A General Overview and Future Perspectives in Colorectal Cancer.
Author:	Marmol, Ines\|Sanchez-de-Diego, Cristina\|Pradilla Dieste, Alberto\|Cerrada, Elena\|Rodriguez Yoldi, Maria Jesus
PMID:	28106826

319.
Journal:	Oncotarget. 2017 Jan 24;8(4):6579-6588.
Title:	Whole-exome sequencing identified mutational profiles of high-grade colon adenomas.
Author:	Lee, Sung Hak\|Jung, Seung Hyun\|Kim, Tae-Min\|Rhee, Je-Keun\|Park, Hyeon-Chun\|Kim, Min Sung\|Kim, Sung Soo\|An, Chang Hyeok\|Lee, Sug Hyung\|Chung, Yeun-Jun
PMID:	28179590

320.
Journal:	Cancer Res. 2017 May 1;77(9):2464-2475.
Title:	High-Throughput Genomic Profiling of Adult Solid Tumors Reveals Novel Insights into Cancer Pathogenesis.
Author:	Hartmaier, Ryan J\|Albacker, Lee A\|Chmielecki, Juliann\|Bailey, Mark\|He, Jie\|Goldberg, Michael E\|Ramkissoon, Shakti\|Suh, James\|Elvin, Julia A\|Chiacchia, Samuel\|Frampton, Garrett M\|Ross, Jeffrey S\|Miller, Vincent\|Stephens, Philip J\|Lipson, Doron
PMID:	28235761

321.
Journal:	J Cancer. 2017 Jan 12;8(2):162-173.
Title:	Construction of a multiplex mutation hot spot PCR panel: the first step towards colorectal cancer genotyping on the GS Junior platform.
Author:	Peterfia, Balint\|Kalmar, Alexandra\|Patai, Arpad V\|Csabai, Istvan\|Bodor, Andras\|Micsik, Tamas\|Wichmann, Barnabas\|Egedi, Krisztina\|Hollosi, Peter\|Kovalszky, Ilona\|Tulassay, Zsolt\|Molnar, Bela
PMID:	28243320

322.
Journal:	PLoS One. 2017 Mar 7;12(3):e0173345.
Title:	Association of SMAD4 mutation with patient demographics, tumor characteristics, and clinical outcomes in colorectal cancer.
Author:	Mehrvarz Sarshekeh, Amir\|Advani, Shailesh\|Overman, Michael J\|Manyam, Ganiraju\|Kee, Bryan K\|Fogelman, David R\|Dasari, Arvind\|Raghav, Kanwal\|Vilar, Eduardo\|Manuel, Shanequa\|Shureiqi, Imad\|Wolff, Robert A\|Patel, Keyur P\|Luthra, Raja\|Shaw, Kenna\|Eng, Cathy\|Ma
PMID:	28267766

323.
Journal:	J Gastrointest Oncol. 2017 Feb;8(1):164-172.
Title:	Potential actionable targets in appendiceal cancer detected by immunohistochemistry, fluorescent in situ hybridization, and mutational analysis.
Author:	Borazanci, Erkut\|Millis, Sherri Z\|Kimbrough, Jeffery\|Doll, Nancy\|Von Hoff, Daniel\|Ramanathan, Ramesh K
PMID:	28280620

324.
Journal:	Am J Transl Res. 2017 Feb 15;9(2):774-790. eCollection 2017.
Title:	Thymoquinone potentiates chemoprotective effect of Vitamin D3 against colon cancer: a pre-clinical finding.
Author:	Mohamed, Amr M\|Refaat, Bassem A\|El-Shemi, Adel G\|Kensara, Osama A\|Ahmad, Jawwad\|Idris, Shakir
PMID:	28337306

325.
Journal:	World J Gastroenterol. 2017 Mar 14;23(10):1816-1827.
Title:	miR-34a mediates oxaliplatin resistance of colorectal cancer cells by inhibiting macroautophagy via transforming growth factor-beta/Smad4 pathway.
Author:	Sun, Chen\|Wang, Fu-Jing\|Zhang, Hao-Gang\|Xu, Xun-Zheng\|Jia, Rui-Chun\|Yao, Lei\|Qiao, Peng-Fei
PMID:	28348487

326.
Journal:	Oncotarget. 2017 Mar 21;8(12):20198-20212.
Title:	Prognostic value of loss of heterozygosity and sub-cellular localization of SMAD4 varies with tumor stage in colorectal cancer.
Author:	Jia, Xu\|Shanmugam, Chandrakumar\|Paluri, Ravi K\|Jhala, Nirag C\|Behring, Michael P\|Katkoori, Venkat R\|Sugandha, Shajan P\|Bae, Sejong\|Samuel, Temesgen\|Manne, Upender
PMID:	28423626

327.
Journal:	Anat Rec (Hoboken). 2017 Sep;300(9):1560-1569.
Title:	Smad4 Inhibits VEGF-A and VEGF-C Expressions via Enhancing Smad3 Phosphorylation in Colon Cancer.
Author:	Li, Xuemei\|Li, Xinlei\|Lv, Xiaohong\|Xiao, Jianbing\|Liu, Baoquan\|Zhang, Yafang
PMID:	28445620

328.
Journal:	Target Oncol. 2017 Jun;12(3):265-275.
Title:	What We Know About Stage II and III Colon Cancer: It's Still Not Enough.
Author:	Puccini, Alberto\|Berger, Martin D\|Zhang, Wu\|Lenz, Heinz-Josef
PMID:	28504299

329.
Journal:	Gastroenterology. 2017 Aug;153(2):470-479.e4.
Title:	Statin Use After Diagnosis of Colon Cancer and Patient Survival.
Author:	Voorneveld, Philip W\|Reimers, Marlies S\|Bastiaannet, Esther\|Jacobs, Rutger J\|van Eijk, Ronald\|Zanders, Marjolein M J\|Herings, Ron M C\|van Herk-Sukel, Myrthe P P\|Kodach, Liudmila L\|van Wezel, Tom\|Kuppen, Peter J K\|Morreau, Hans\|van de Velde, Cornelis J H\|H
PMID:	28512021

330.
Journal:	PLoS One. 2017 May 17;12(5):e0178275.
Title:	Correction: Association of SMAD4 mutation with patient demographics, tumor characteristics, and clinical outcomes in colorectal cancer.
Author:
PMID:	28545046

331.
Journal:	EBioMedicine. 2017 Jun;20:39-49.
Title:	A Specific Mutational Signature Associated with DNA 8-Oxoguanine Persistence in MUTYH-defective Colorectal Cancer.
Author:	Viel, Alessandra\|Bruselles, Alessandro\|Meccia, Ettore\|Fornasarig, Mara\|Quaia, Michele\|Canzonieri, Vincenzo\|Policicchio, Eleonora\|Urso, Emanuele Damiano\|Agostini, Marco\|Genuardi, Maurizio\|Lucci-Cordisco, Emanuela\|Venesio, Tiziana\|Martayan, Aline\|Diodoro, M
PMID:	28551381

332.
Journal:	Hum Pathol. 2017 Aug;66:34-39.
Title:	Significance of positive and inhibitory regulators in the TGF-beta signaling pathway in colorectal cancers.
Author:	Coates, Ryan F\|Gardner, Juli-Anne\|Gao, Yuan\|Cortright, Valerie M\|Mitchell, Jeannette M\|Ashikaga, Takamaru\|Skelly, Joan\|Yang, Michelle X
PMID:	28601657

333.
Journal:	JAMA Oncol. 2017 Nov 1;3(11):1546-1553.
Title:	Genomic Profiling of Small-Bowel Adenocarcinoma.
Author:	Schrock, Alexa B\|Devoe, Craig E\|McWilliams, Robert\|Sun, James\|Aparicio, Thomas\|Stephens, Philip J\|Ross, Jeffrey S\|Wilson, Richard\|Miller, Vincent A\|Ali, Siraj M\|Overman, Michael J
PMID:	28617917

334.
Journal:	Theranostics. 2017 Apr 10;7(7):1901-1913.
Title:	Therapeutic Inhibition of miR-4260 Suppresses Colorectal Cancer via Targeting MCC and SMAD4.
Author:	Xiao, Junjie\|Lv, Dongchao\|Zhou, Jinzhe\|Bei, Yihua\|Chen, Ting\|Hu, Muren\|Zhou, Qiulian\|Fu, Siyi\|Huang, Qi
PMID:	28638476

335.
Journal:	Sci Rep. 2017 Jun 27;7(1):4281.
Title:	Downregulated USP3 mRNA functions as a competitive endogenous RNA of SMAD4 by sponging miR-224 and promotes metastasis in colorectal cancer.
Author:	Wang, Zaozao\|Yang, Jie\|Di, Jiabo\|Cui, Ming\|Xing, Jiadi\|Wu, Fan\|Wu, Wei\|Yang, Hong\|Zhang, Chenghai\|Yao, Zhendan\|Zhang, Nan\|Jiang, Beihai\|Su, Xiangqian
PMID:	28655924

336.
Journal:	Adv Med Biol. 2017 1st Quarter;118:83-122.
Title:	Haploinsufficient tumor suppressor genes.
Author:	Inoue, Kazushi\|Fry, Elizabeth A
PMID:	28680740

337.
Journal:	Tumour Biol. 2017 Jul;39(7):1010428317714899.
Title:	Screening key genes and miRNAs in early-stage colon adenocarcinoma by RNA-sequencing.
Author:	Liu, Jixi\|Liu, Fang\|Li, Xiaoou\|Song, Xin\|Zhou, Lei\|Jie, Jianzheng
PMID:	28714374

338.
Journal:	Oncogene. 2017 Nov 16;36(46):6480-6489.
Title:	Tumor microenvironment confers mTOR inhibitor resistance in invasive intestinal adenocarcinoma.
Author:	Fujishita, T\|Kojima, Y\|Kajino-Sakamoto, R\|Taketo, M M\|Aoki, M
PMID:	28759045

339.
Journal:	Oncol Rep. 2017 Oct;38(4):2317-2324.
Title:	Smad4 re-expression increases the sensitivity to parthenolide in colorectal cancer.
Author:	Li, Xuemei\|Yang, Huike\|Ke, Jia\|Liu, Baoquan\|Lv, Xiaohong\|Li, Xinlei\|Zhang, Yafang
PMID:	28902368

340.
Journal:	Int J Med Sci. 2017 Aug 8;14(10):937-942.
Title:	miR-224 Controls Human Colorectal Cancer Cell Line HCT116 Proliferation by Targeting Smad4.
Author:	Zhou, Jinzhe\|Hu, Muren\|Wang, Fei\|Song, Meiyi\|Huang, Qi\|Ge, Bujun
PMID:	28924364

341.
Journal:	J Exp Clin Cancer Res. 2017 Sep 22;36(1):131.
Title:	miR-19b-3p promotes colon cancer proliferation and oxaliplatin-based chemoresistance by targeting SMAD4: validation by bioinformatics and experimental analyses.
Author:	Jiang, Tao\|Ye, Ling\|Han, Zhongbo\|Liu, Yuan\|Yang, Yinxue\|Peng, Zhihai\|Fan, Junwei
PMID:	28938919

342.
Journal:	Mol Med Rep. 2017 Nov;16(5):7752-7758.
Title:	Hedyotis diffusa Willd suppresses metastasis in 5fluorouracilresistant colorectal cancer cells by regulating the TGFbeta signaling pathway.
Author:	Lai, Zijun\|Yan, Zhaokun\|Chen, Wujin\|Peng, Jun\|Feng, Jianyu\|Li, Qiongyu\|Jin, Yiyi\|Lin, Jiumao
PMID:	28944846

343.
Journal:	PLoS One. 2017 Oct 17;12(10):e0186271.
Title:	Colorectal carcinoma tumour budding and podia formation in the xenograft microenvironment.
Author:	Prall, Friedrich\|Maletzki, Claudia\|Huhns, Maja\|Krohn, Mathias\|Linnebacher, Michael
PMID:	29040282

344.
Journal:	Clin Transl Gastroenterol. 2017 Oct 19;8(10):e124.
Title:	Increased Frequency of KRAS Mutations in African Americans Compared with Caucasians in Sporadic Colorectal Cancer.
Author:	Staudacher, Jonas J\|Yazici, Cemal\|Bul, Vadim\|Zeidan, Joseph\|Khalid, Ahmer\|Xia, Yinglin\|Krett, Nancy\|Jung, Barbara
PMID:	29048416

345.
Journal:	PLoS One. 2017 Oct 24;12(10):e0186718.
Title:	miR-27a induced by colon cancer cells in HLECs promotes lymphangiogenesis by targeting SMAD4.
Author:	Xu, Qi\|Tong, Jin-Lu\|Zhang, Chen-Peng\|Xiao, Qian\|Lin, Xiao-Lin\|Xiao, Xiu-Ying
PMID:	29065177

346.
Journal:	Oncotarget. 2017 Aug 21;8(42):72352-72362.
Title:	Acquired somatic TP53 or PIK3CA mutations are potential predictors of when polyps evolve into colorectal cancer.
Author:	Chang, Pi-Yueh\|Chen, Jinn-Shiun\|Chang, Shih-Cheng\|Wang, Mei-Chia\|Chang, Nai-Chung\|Wen, Ying-Hao\|Tsai, Wen-Sy\|Liu, Wei-Hsiu\|Liu, Hsiu-Ling\|Lu, Jang-Jih
PMID:	29069792

347.
Journal:	Cell Rep. 2017 Dec 26;21(13):3833-3845.
Title:	Degree of Tissue Differentiation Dictates Susceptibility to BRAF-Driven Colorectal Cancer.
Author:	Tong, Kevin\|Pellon-Cardenas, Oscar\|Sirihorachai, Veerin R\|Warder, Bailey N\|Kothari, Om A\|Perekatt, Ansu O\|Fokas, Emily E\|Fullem, Robert L\|Zhou, Anbo\|Thackray, Joshua K\|Tran, Hiep\|Zhang, Lanjing\|Xing, Jinchuan\|Verzi, Michael P
PMID:	29281831

348.
Journal:	Mol Carcinog. 2018 Jan;57(1):114-124.
Title:	Early genetic aberrations in patients with sporadic colorectal cancer.
Author:	Druliner, Brooke R\|Ruan, Xiaoyang\|Sicotte, Hugues\|O'Brien, Daniel\|Liu, Hongfang\|Kocher, Jean-Pierre A\|Boardman, Lisa
PMID:	28926134

349.
Journal:	Carcinogenesis. 2018 Jan 12;39(1):36-46.
Title:	Potent suppression of both spontaneous and carcinogen-induced colitis-associated colorectal cancer in mice by dietary celastrol supplementation.
Author:	Barker, Emily C\|Kim, Byung-Gyu\|Yoon, Ji Hee\|Tochtrop, Gregory P\|Letterio, John J\|Choi, Sung Hee
PMID:	29069290

350.
Journal:	Gastroenterology. 2018 Mar;154(4):897-905.e1.
Title:	Germline Genetic Features of Young Individuals With Colorectal Cancer.
Author:	Stoffel, Elena M\|Koeppe, Erika\|Everett, Jessica\|Ulintz, Peter\|Kiel, Mark\|Osborne, Jenae\|Williams, Linford\|Hanson, Kristen\|Gruber, Stephen B\|Rozek, Laura S
PMID:	29146522

351.
Journal:	Clin Cancer Res. 2018 Mar 1;24(5):1062-1072.
Title:	Classifying Colorectal Cancer by Tumor Location Rather than Sidedness Highlights a Continuum in Mutation Profiles and Consensus Molecular Subtypes.
Author:	Loree, Jonathan M\|Pereira, Allan A L\|Lam, Michael\|Willauer, Alexandra N\|Raghav, Kanwal\|Dasari, Arvind\|Morris, Van K\|Advani, Shailesh\|Menter, David G\|Eng, Cathy\|Shaw, Kenna\|Broaddus, Russell\|Routbort, Mark J\|Liu, Yusha\|Morris, Jeffrey S\|Luthra, Rajyalakshm
PMID:	29180604

352.
Journal:	Br J Cancer. 2018 Jan;118(1):106-116.
Title:	Mechanisms of inactivation of the tumour suppressor gene RHOA in colorectal cancer.
Author:	Dopeso, Higinio\|Rodrigues, Paulo\|Bilic, Josipa\|Bazzocco, Sarah\|Carton-Garcia, Fernando\|Macaya, Irati\|de Marcondes, Priscila Guimaraes\|Anguita, Estefania\|Masanas, Marc\|Jimenez-Flores, Lizbeth M\|Martinez-Barriocanal, Agueda\|Nieto, Rocio\|Segura, Miguel F\|Sch
PMID:	29206819

353.
Journal:	Cancer Biol Ther. 2018 Feb 1;19(2):105-112.
Title:	Multispectral imaging reveals hyper active TGF-beta signaling in colorectal cancer.
Author:	Yang, Lei\|Liu, Zheng\|Tan, Jinjing\|Dong, Hongwei\|Zhang, Xiaojing
PMID:	29219668

354.
Journal:	Cancer Cell. 2018 Jan 8;33(1):125-136.e3.
Title:	Clinical Sequencing Defines the Genomic Landscape of Metastatic Colorectal Cancer.
Author:	Yaeger, Rona\|Chatila, Walid K\|Lipsyc, Marla D\|Hechtman, Jaclyn F\|Cercek, Andrea\|Sanchez-Vega, Francisco\|Jayakumaran, Gowtham\|Middha, Sumit\|Zehir, Ahmet\|Donoghue, Mark T A\|You, Daoqi\|Viale, Agnes\|Kemeny, Nancy\|Segal, Neil H\|Stadler, Zsofia K\|Varghese, Anna
PMID:	29316426

355.
Journal:	Cancer Metastasis Rev. 2018 Mar;37(1):173-187.
Title:	Mutations of key driver genes in colorectal cancer progression and metastasis.
Author:	Huang, Dongdong\|Sun, Wenjie\|Zhou, Yuwei\|Li, Peiwei\|Chen, Fang\|Chen, Hanwen\|Xia, Dajing\|Xu, Enping\|Lai, Maode\|Wu, Yihua\|Zhang, Honghe
PMID:	29322354

356.
Journal:	Oncotarget. 2017 Dec 12;9(1):969-981.
Title:	Genomic landscape of colitis-associated cancer indicates the impact of chronic inflammation and its stratification by mutations in the Wnt signaling.
Author:	Fujita, Masashi\|Matsubara, Nagahide\|Matsuda, Ikuo\|Maejima, Kazuhiro\|Oosawa, Ayako\|Yamano, Tomoki\|Fujimoto, Akihiro\|Furuta, Mayuko\|Nakano, Kaoru\|Oku-Sasaki, Aya\|Tanaka, Hiroko\|Shiraishi, Yuichi\|Mateos, Raul Nicolas\|Nakai, Kenta\|Miyano, Satoru\|Tomita, Naohi
PMID:	29416670

357.
Journal:	Med Sci Monit. 2018 Feb 21;24:1080-1088.
Title:	Preliminary Study of the Role F-Box Protein 32 (FBXO32) in Colorectal Neoplasms Through the Transforming Growth Factor beta (TGF-beta)/Smad4 Signalling Pathway.
Author:	Yuan, Xuemin\|Zhang, Zhen\|Jiang, Kaitong\|Wang, Xinguo\|Li, Yanqing
PMID:	29465067

358.
Journal:	J Mol Histol. 2018 Jun;49(3):235-244.
Title:	Smad4 and epithelial-mesenchymal transition proteins in colorectal carcinoma: an immunohistochemical study.
Author:	Ioannou, M\|Kouvaras, E\|Papamichali, R\|Samara, M\|Chiotoglou, I\|Koukoulis, G
PMID:	29468299

359.
Journal:	Int J Biol Sci. 2018 Jan 12;14(2):111-123.
Title:	The role of TGF-beta/SMAD4 signaling in cancer.
Author:	Zhao, Ming\|Mishra, Lopa\|Deng, Chu-Xia
PMID:	29483830

360.
Journal:	Clin Exp Pharmacol Physiol. 2018 Jul;45(7):729-741.
Title:	Inhibition of microRNA-21-3p suppresses proliferation as well as invasion and induces apoptosis by targeting RNA-binding protein with multiple splicing through Smad4/extra cellular signal-regulated protein kinase signalling pathway in human colorectal can
Author:	Hou, Nengyi\|Guo, Zhiyi\|Zhao, Gaoping\|Jia, Guiqing\|Luo, Bin\|Shen, Xiaogang\|Bai, Yifeng
PMID:	29542167

361.
Journal:	Eur J Surg Oncol. 2018 May;44(5):684-692.
Title:	SMAD4 gene mutation predicts poor prognosis in patients undergoing resection for colorectal liver metastases.
Author:	Mizuno, Takashi\|Cloyd, Jordan M\|Vicente, Diego\|Omichi, Kiyohiko\|Chun, Yun Shin\|Kopetz, Scott E\|Maru, Dipen\|Conrad, Claudius\|Tzeng, Ching-Wei D\|Wei, Steven H\|Aloia, Thomas A\|Vauthey, Jean-Nicolas
PMID:	29551247

362.
Journal:	Gastroenterol Hepatol Bed Bench. 2018 Winter;11(1):34-41.
Title:	Extracted metabolite from Streptomyces Levis ABRIINW111 altered the gene expression in colon cancer.
Author:	Fatourachi, Parisa\|Faramarziyan Azimi Maragheh, Behnaz\|Mohammadi, Seyede Momeneh\|Valipour, Behnaz\|Dehnad, Alireza\|Nozad Charoudeh, Hojjatollah
PMID:	29564063

363.
Journal:	Oncotarget. 2017 Dec 20;9(22):15984-15996.
Title:	The role and gene expression profile of SOCS3 in colorectal carcinoma.
Author:	Dong, Xing\|Wang, Jing\|Tang, Bo\|Hao, Yeng-Xue\|Li, Ping-Yang\|Li, Shi-Yong\|Yu, Pei-Wu
PMID:	29662621

364.
Journal:	Nutr Res. 2018 Mar;51:67-81.
Title:	Curcumin induces apoptosis and cell cycle arrest via the activation of reactive oxygen species-independent mitochondrial apoptotic pathway in Smad4 and p53 mutated colon adenocarcinoma HT29 cells.
Author:	Agarwal, Ayushi\|Kasinathan, Akiladdevi\|Ganesan, Ramamoorthi\|Balasubramanian, Akhila\|Bhaskaran, Jahnavi\|Suresh, Samyuktha\|Srinivasan, Revanth\|Aravind, K B\|Sivalingam, Nageswaran
PMID:	29673545

365.
Journal:	Virchows Arch. 2018 Jun;472(6):959-968.
Title:	Performance validation of an amplicon-based targeted next-generation sequencing assay and mutation profiling of 648 Chinese colorectal cancer patients.
Author:	Wang, Yajian\|Liu, Haijing\|Hou, Yingyong\|Zhou, Xiaoyan\|Liang, Li\|Zhang, Zhihong\|Shi, Huaiyin\|Xu, Sanpeng\|Hu, Peizhen\|Zheng, Zuyu\|Liu, Rui\|Tang, Tingdong\|Ye, Feng\|Liang, Zhiyong\|Bu, Hong
PMID:	29705968

366.
Journal:	Br J Pharmacol. 2018 Aug;175(15):3111-3130.
Title:	PEP06 polypeptide 30 exerts antitumour effect in colorectal carcinoma via inhibiting epithelial-mesenchymal transition.
Author:	Yu, Siming\|Li, Linna\|Tian, Wei\|Nie, Dan\|Mu, Wei\|Qiu, Fang\|Liu, Yu\|Liu, Xinghan\|Wang, Xiaofeng\|Du, Zhimin\|Chu, Wen-Feng\|Yang, Baofeng
PMID:	29722931

367.
Journal:	Surg Oncol. 2018 Jun;27(2):280-288.
Title:	Clinical significance and prognostic relevance of KRAS, BRAF, PI3K and TP53 genetic mutation analysis for resectable and unresectable colorectal liver metastases: A systematic review of the current evidence.
Author:	Tsilimigras, Diamantis I\|Ntanasis-Stathopoulos, Ioannis\|Bagante, Fabio\|Moris, Demetrios\|Cloyd, Jordan\|Spartalis, Eleftherios\|Pawlik, Timothy M
PMID:	29937183

368.
Journal:	Oncotarget. 2018 Jun 8;9(44):27412-27422.
Title:	The landscape of somatic mutation in sporadic Chinese colorectal cancer.
Author:	Liu, Zhe\|Yang, Chao\|Li, Xiangchun\|Luo, Wen\|Roy, Bhaskar\|Xiong, Teng\|Zhang, Xiuqing\|Yang, Huanming\|Wang, Jian\|Ye, Zhenhao\|Chen, Yang\|Song, Jinghe\|Ma, Shuai\|Zhou, Yong\|Yang, Min\|Fang, Xiaodong\|Du, Jie
PMID:	29937994

369.
Journal:	BMC Cancer. 2018 Jun 27;18(1):695.
Title:	Gene promoter and exon DNA methylation changes in colon cancer development - mRNA expression and tumor mutation alterations.
Author:	Molnar, Bela\|Galamb, Orsolya\|Peterfia, Balint\|Wichmann, Barnabas\|Csabai, Istvan\|Bodor, Andras\|Kalmar, Alexandra\|Szigeti, Krisztina Andrea\|Bartak, Barbara Kinga\|Nagy, Zsofia Brigitta\|Valcz, Gabor\|Patai, Arpad V\|Igaz, Peter\|Tulassay, Zsolt
PMID:	29945573

370.
Journal:	Eur J Hum Genet. 2018 Jul 2. pii: 10.1038/s41431-018-0207-2.
Title:	Optimization of the diagnosis of inherited colorectal cancer using NGS and capture of exonic and intronic sequences of panel genes.
Author:	Baert-Desurmont, Stephanie\|Coutant, Sophie\|Charbonnier, Francoise\|Macquere, Pierre\|Lecoquierre, Francois\|Schwartz, Mathias\|Blanluet, Maud\|Vezain, Myriam\|Lanos, Raphael\|Quenez, Olivier\|Bou, Jacqueline\|Bouvignies, Emilie\|Fourneaux, Steeve\|Manase, Sandrine\|V
PMID:	29967336

371.
Journal:	J Cancer Res Ther. 2018;14(4):838-843.
Title:	Post-transcriptional regulation DPC4 gene by miR-190 in colorectal cancer cells.
Author:	Xie, Bin\|Deng, Zhenghao\|Pan, Yu\|Fu, Chunyan\|Fan, Songqing\|Tao, Yongguang\|Zhou, Jianhua\|Xiao, Desheng
PMID:	29970662

372.
Journal:	World J Surg Oncol. 2018 Jul 5;16(1):128.
Title:	Differences in gene mutations according to gender among patients with colorectal cancer.
Author:	Tsai, Yi-Jian\|Huang, Sheng-Chieh\|Lin, Hung-Hsin\|Lin, Chun-Chi\|Lan, Yuan-Tzu\|Wang, Huann-Sheng\|Yang, Shung-Haur\|Jiang, Jeng-Kai\|Chen, Wei-Shone\|Lin, Tzu-Chen\|Lin, Jen-Kou\|Chang, Shih-Ching
PMID:	29976257

373.
Journal:	Cancer Res. 2018 Sep 1;78(17):4878-4890.
Title:	SMAD4 Suppresses WNT-Driven Dedifferentiation and Oncogenesis in the Differentiated Gut Epithelium.
Author:	Perekatt, Ansu O\|Shah, Pooja P\|Cheung, Shannon\|Jariwala, Nidhi\|Wu, Alex\|Gandhi, Vishal\|Kumar, Namit\|Feng, Qiang\|Patel, Neeket\|Chen, Lei\|Joshi, Shilpy\|Zhou, Anbo\|Taketo, M Mark\|Xing, Jinchuan\|White, Eileen\|Gao, Nan\|Gatza, Michael L\|Verzi, Michael P
PMID:	29986996

374.
Journal:	Oncologist. 2018 Jul 17. pii: theoncologist.2018-0117.
Title:	Impact of Patient Age on Molecular Alterations of Left-Sided Colorectal Tumors.
Author:	Puccini, Alberto\|Lenz, Heinz-Josef\|Marshall, John L\|Arguello, David\|Raghavan, Derek\|Korn, W Michael\|Weinberg, Benjamin A\|Poorman, Kelsey\|Heeke, Arielle L\|Philip, Philip A\|Shields, Anthony F\|Goldberg, Richard M\|Salem, Mohamed E
PMID:	30018131

375.
Journal:	BMC Cancer. 2018 Jul 20;18(1):752.
Title:	Genomic alterations accompanying tumour evolution in colorectal cancer: tracking the differences between primary tumours and synchronous liver metastases by whole-exome sequencing.
Author:	Mogensen, M B\|Rossing, M\|Ostrup, O\|Larsen, P N\|Heiberg Engel, P J\|Jorgensen, L N\|Hogdall, E V\|Eriksen, J\|Ibsen, P\|Jess, P\|Grauslund, M\|Nielsen, H J\|Nielsen, F C\|Vainer, B\|Osterlind, K
PMID:	30029640

376.
Journal:	Cell Mol Gastroenterol Hepatol. 2018 May 24;6(3):257-276.
Title:	Epithelial Smad4 Deletion Up-Regulates Inflammation and Promotes Inflammation-Associated Cancer.
Author:	Means, Anna L\|Freeman, Tanner J\|Zhu, Jing\|Woodbury, Luke G\|Marincola-Smith, Paula\|Wu, Chao\|Meyer, Anne R\|Weaver, Connie J\|Padmanabhan, Chandrasekhar\|An, Hanbing\|Zi, Jinghuan\|Wessinger, Bronson C\|Chaturvedi, Rupesh\|Brown, Tasia D\|Deane, Natasha G\|Coffey, R
PMID:	30109253

377.
Journal:	Clin Colorectal Cancer. 2018 Jul 17. pii: S1533-0028(18)30133-6.
Title:	Prognostic Implications of Mucinous Differentiation in Metastatic Colorectal Carcinoma Can Be Explained by Distinct Molecular and Clinicopathologic Characteristics.
Author:	Khan, Maliha\|Loree, Jonathan M\|Advani, Shailesh M\|Ning, Jing\|Li, Wen\|Pereira, Allan A L\|Lam, Michael\|Raghav, Kanwal\|Morris, Van K\|Broaddus, Russell\|Maru, Dipen\|Overman, Michael J\|Kopetz, Scott
PMID:	30205948

378.
Journal:	PLoS One. 2018 Sep 26;13(9):e0203885.
Title:	Novel genetic mutations detected by multigene panel are associated with hereditary colorectal cancer predisposition.
Author:	Martin-Morales, Lorena\|Rofes, Paula\|Diaz-Rubio, Eduardo\|Llovet, Patricia\|Lorca, Victor\|Bando, Inmaculada\|Perez-Segura, Pedro\|de la Hoya, Miguel\|Garre, Pilar\|Garcia-Barberan, Vanesa\|Caldes, Trinidad
PMID:	30256826

379.
Journal:	Int J Oncol. 2018 Oct 10.
Title:	HLTF suppresses the migration and invasion of colorectal cancer cells via TGFbeta/SMAD signaling in vitro.
Author:	Liu, Li\|Liu, Huan\|Zhou, Yangying\|He, Jiaofeng\|Liu, Qiong\|Wang, Jian\|Zeng, Manting\|Yuan, Dan\|Tan, Fengbo\|Zhou, Yuan\|Pei, Haiping\|Zhu, Hong
PMID:	30320371