Primary Site >> Colorectal Cancer
Gene >> SMAD4
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Ref: Juvenile Polyposis Syndrome PMID: 20301642 |
Ref: Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers. PMID: 8673134 Ref: MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma. PMID: 8752209 Ref: Somatic alterations of the DPC4 gene in human colorectal cancers in vivo. PMID: 8898652 Ref: Infrequent DPC4 gene mutation in esophageal cancer, gastric cancer and ulcerative colitis-associated neoplasms. PMID: 8957088 |
Ref: Smad5, a tumor suppressor candidate at 5q31.1, is hemizygously lost and not mutated in the retained allele in human leukemia cell line HL60. PMID: 9264367 Ref: Comparative mutational analysis of DPC4 (Smad4) in prostatic and colorectal carcinomas. PMID: 9285566 Ref: Expression and mutational analysis of the DCC, DPC4, and MADR2/JV18-1 genes in neuroblastoma. PMID: 9288786 Ref: Molecular biology of colorectal cancer. PMID: 9438104 |
Ref: Genomic structure of the human Smad3 gene and its infrequent alterations in colorectal cancers. PMID: 9464505 Ref: Targeted deletion of Smad4 shows it is required for transforming growth factor beta and activin signaling in colorectal cancer cells. PMID: 9482899 Ref: Alterations in pancreatic, biliary, and breast carcinomas support MKK4 as a genetically targeted tumor suppressor gene. PMID: 9622070 Ref: Mutational analysis of the tumor suppressor Smad2 in acute lymphoid and myeloid leukemia. PMID: 9665198 Ref: Smad3 mutant mice develop metastatic colorectal cancer. PMID: 9753318 Ref: Smad4 (DPC4)--a potent tumour suppressor? PMID: 9862572 |
Ref: Higher frequency of Smad4 gene mutation in human colorectal cancer with distant metastasis. PMID: 10340381 Ref: DPC4/SMAD4 mediated tumor suppression of colon carcinoma cells is associated with reduced urokinase expression. PMID: 10340387 Ref: Expression of Smad proteins in human colorectal cancer. PMID: 10389752 Ref: Frequent 4-bp deletion in exon 9 of the SMAD4/MADH4 gene in familial juvenile polyposis patients. PMID: 10398437 Ref: Screening SMAD1, SMAD2, SMAD3, and SMAD5 for germline mutations in juvenile polyposis syndrome. PMID: 10446110 Ref: Inactivation of both alleles of the DPC4/SMAD4 gene in advanced colorectal cancers: identification of seven novel somatic mutations in tumors from Japanese patients. PMID: 10479724 Ref: Smad4/DPC4 silencing and hyperactive Ras jointly disrupt transforming growth factor-beta antiproliferative responses in colon cancer cells. PMID: 10559252 Ref: Frequent allelic imbalance on chromosome 18q21 in early superficial colorectal cancers. PMID: 10665650 Ref: Sequence of molecular genetic events in colorectal tumorigenesis. PMID: 10772417 Ref: The molecular basis of colorectal carcinogenesis. PMID: 17023910 |
Ref: Distinct genetic profiles in colorectal tumors with or without the CpG island methylator phenotype. PMID: 10639144 Ref: DCC and SMAD4 alterations in human colorectal and pancreatic tumor dissemination. PMID: 10698524 Ref: A dominant negative mutation of transforming growth factor-beta receptor type II gene in microsatellite stable oesophageal carcinoma. PMID: 10789724 Ref: No SMAD4 hypermethylation in colorectal cancer. PMID: 10993648 Ref: The 18q21 region in colorectal and pancreatic cancer: independent loss of DCC and DPC4 expression. PMID: 11040453 Ref: Expression of Smad4 Gene in Pichia pastoris and Identification of the Protein. PMID: 12075447 |
Ref: Nuclear localization of Dpc4 (Madh4, Smad4) in colorectal carcinomas and relation to mismatch repair/transforming growth factor-beta receptor defects. PMID: 11159190 Ref: Molecular genetic alterations in hamartomatous polyps and carcinomas of patients with Peutz-Jeghers syndrome. PMID: 11215281 Ref: Genetic pathways in the evolution of morphologically distinct colorectal neoplasms. PMID: 11289147 Ref: Chromosome 18 deletions are common events in classical midgut carcinoid tumors. PMID: 11351300 Ref: CDX2 mutations do not account for juvenile polyposis or Peutz-Jeghers syndrome and occur infrequently in sporadic colorectal cancers. PMID: 11355940 Ref: Loss of heterozygosity of DPC4 tumor suppressor gene in human sporadic colon cancer. PMID: 11357936 Ref: Combined copy status of 18q21 genes in colorectal cancer shows frequent retention of SMAD7. PMID: 11391794 Ref: [Genetic changes in liver metastasis of colorectal cancer and their clinical application]. PMID: 11393998 Ref: KAI1, CAR, and Smad4 expression in the progression of colorectal tumor. PMID: 11480790 Ref: SMAD4 mutations in colorectal cancer probably occur before chromosomal instability, but after divergence of the microsatellite instability pathway. PMID: 11481457 Ref: Germline mutations in BMPR1A/ALK3 cause a subset of cases of juvenile polyposis syndrome and of Cowden and Bannayan-Riley-Ruvalcaba syndromes. PMID: 11536076 Ref: Loss of Smad4 function in pancreatic tumors: C-terminal truncation leads to decreased stability. PMID: 11553622 Ref: Loss of heterozygosity and HIV infection in patients with anal squamous-cell carcinoma. PMID: 11598481 |
Ref: Transforming growth factor beta 1 induces proliferation in colon carcinoma cells by Ras-dependent, smad-independent down-regulation of p21cip1. PMID: 11784716 Ref: Frequent loss of SMAD4/DPC4 protein in colorectal cancers. PMID: 12077092 Ref: Genetic and epigenetic alterations in colon cancer. PMID: 12142355 Ref: No effects of Smad2 (madh2) null mutation on malignant progression of intestinal polyps in Apc(delta716) knockout mice. PMID: 12183405 Ref: Smad4 induces the tumor suppressor E-cadherin and P-cadherin in colon carcinoma cells. PMID: 12203117 Ref: High resolution analysis of chromosome 18 alterations in ulcerative colitis-related colorectal cancer. PMID: 12237237 Ref: SMAD4 is a predictive marker for 5-fluorouracil-based chemotherapy in patients with colorectal cancer. PMID: 12237773 Ref: Poorly differentiated adenocarcinoma and mucinous carcinoma of the colon and rectum show higher rates of loss of heterozygosity and loss of E-cadherin expression due to methylation of promoter region. PMID: 12397640 Ref: [Genetic pathways in colorectal cancer: interest for the pathologist]. PMID: 12410150 Ref: Germline SMAD4 or BMPR1A mutations and phenotype of juvenile polyposis. PMID: 12417513 Ref: [Juvenile polyposis coli. The usefulness of a genetic study and the role of surgical treatment]. PMID: 12483142 |
Ref: Numerical abnormalities of chromosomes 17 and 18 in sporadic colorectal cancer: Incidence and correlation with clinical and biological findings and the prognosis of the disease. PMID: 12500293 Ref: Serrated adenomas and mixed polyposis caused by a splice acceptor deletion in the mouse Smad4 gene. PMID: 12557227 Ref: Infrequent mutation of the tumour-suppressor gene Smad4 in early-stage colorectal cancer. PMID: 12569386 Ref: Exclusion of Madh2, Madh4, and Madh7 as candidates for the modifier of Min 2 (Mom2) locus. PMID: 12584607 Ref: SMAD7 is a prognostic marker in patients with colorectal cancer. PMID: 12584741 Ref: TGF-beta-induced nuclear localization of Smad2 and Smad3 in Smad4 null cancer cell lines. PMID: 12618756 Ref: Role of Smad4 (DPC4) inactivation in human cancer. PMID: 12821112 Ref: Mutational analysis of TGF-beta type II receptor, Smad2, Smad3, Smad4, Smad6 and Smad7 genes in colorectal cancer. PMID: 12866583 Ref: Loss of Smad signaling in human colorectal cancer is associated with advanced disease and poor prognosis. PMID: 12967141 Ref: Activin A induces phosphorylation of Smad2 but not complex formation of Smad2 with Smad4 in human colon cancer cell line HT-29. PMID: 14520001 Ref: Carcinogenesis in MYH-associated polyposis follows a distinct genetic pathway. PMID: 14633673 |
Ref: Tumor-derived C-terminal mutations of Smad4 with decreased DNA binding activity and enhanced intramolecular interaction. PMID: 14647410 Ref: Bone morphogenetic protein 2 is expressed by, and acts upon, mature epithelial cells in the colon. PMID: 14699493 Ref: Molecular and functional consequences of Smad4 C-terminal missense mutations in colorectal tumour cells. PMID: 14715079 Ref: Transforming growth factor-beta signaling is differentially inhibited by Smad2D450E and Smad3D407E. PMID: 14720321 Ref: Epstein-barr virus-positive gastric carcinoma has a distinct protein expression profile in comparison with epstein-barr virus-negative carcinoma. PMID: 15014022 Ref: Status of the DPC4 tumor suppressor gene in sporadic colon adenocarcinoma of Croatian patients: identification of a novel somatic mutation. PMID: 15063137 Ref: [Alterations of p53 gene and microsatellite instability in ulcerative colitis and ulcerative colitis-associated colorectal cancer]. PMID: 15067728 Ref: Comparative analysis of cell adhesion molecules, cell cycle regulatory proteins, mismatch repair genes, cyclooxygenase-2, and DPC4 in carcinomas arising in inflammatory bowel disease and sporadic colon cancer. PMID: 15069531 Ref: Loss of Smad4 correlates with loss of the invasion suppressor E-cadherin in advanced colorectal carcinomas. PMID: 15095268 Ref: Loss of SMAD4 function in small intestinal adenocarcinomas: comparison of genetic and immunohistochemical findings. PMID: 15157044 Ref: Tumor suppressor Smad4 mediates downregulation of the anti-adhesive invasion-promoting matricellular protein SPARC: Landscaping activity of Smad4 as revealed by a "secretome" analysis. PMID: 15188399 Ref: [Growth suppression of colon cancer cells in vitro by DPC4 gene expression and its mechanism]. PMID: 15256118 Ref: APC gene loss of heterozygosity, mutations, E1317Q, and I1307K germ-line variants in sporadic colon cancer in Croatia. PMID: 15507235 Ref: Assessment of K-ras, Smad4 and p53 gene alterations in colorectal metastases and their role in the metastatic process. PMID: 15547741 Ref: Coexpression of matrix metalloproteinase-7 (MMP-7) and epidermal growth factor (EGF) receptor in colorectal cancer: an EGF receptor tyrosine kinase inhibitor is effective against MMP-7-expressing cancer cells. PMID: 15623600 |
Ref: Effect of deleted pancreatic cancer locus 4 gene transfection on biological behaviors of human colorectal carcinoma cells. PMID: 15637742 Ref: Acceleration of Smad2 and Smad3 phosphorylation via c-Jun NH(2)-terminal kinase during human colorectal carcinogenesis. PMID: 15665291 Ref: TGF-beta signaling in colon cancer cells. PMID: 15711891 Ref: [Hereditary colorectal cancer]. PMID: 15725711 Ref: Gene expression profiling of colorectal adenomas and early invasive carcinomas by cDNA array analysis. PMID: 15785755 Ref: SMAD4 as a prognostic marker in colorectal cancer. PMID: 15814640 Ref: Transforming growth factor-beta suppresses nonmetastatic colon cancer through Smad4 and adaptor protein ELF at an early stage of tumorigenesis. PMID: 15899814 Ref: Differential proteome analysis of conditioned media to detect Smad4 regulated secreted biomarkers in colon cancer. PMID: 15912508 Ref: Smad7 induces tumorigenicity by blocking TGF-beta-induced growth inhibition and apoptosis. PMID: 15922743 Ref: Prognostic and predictive relevance of DNAM-1, SOCS6 and CADH-7 genes on chromosome 18q in colorectal cancer. PMID: 16015041 Ref: Analysis of SMAD4/DPC4 gene alterations in multiploid colorectal carcinomas. PMID: 16082587 Ref: Smad4 dependency defines two classes of transforming growth factor {beta} (TGF-{beta}) target genes and distinguishes TGF-{beta}-induced epithelial-mesenchymal transition from its antiproliferative and migratory responses. PMID: 16135802 Ref: SMAD4 levels and response to 5-fluorouracil in colorectal cancer. PMID: 16144935 Ref: Genetic and pathologic changes associated with lymphovascular invasion of colorectal adenocarcinoma. PMID: 16283485 Ref: Deletion mapping of 18q in conventional renal cell carcinoma. PMID: 16337851 |
Ref: Role of Smad proteins in the regulation of NF-kappaB by TGF-beta in colon cancer cells. PMID: 16288847 Ref: Smad3 phosphoisoform-mediated signaling during sporadic human colorectal carcinogenesis. PMID: 16528675 Ref: SMAD4 levels and allelic imbalance in 18q21 in colorectal cancer. PMID: 16533795 Ref: Combined array-comparative genomic hybridization and single-nucleotide polymorphism-loss of heterozygosity analysis reveals complex changes and multiple forms of chromosomal instability in colorectal cancers. PMID: 16585170 Ref: A preliminary investigation demonstrating the effect of quercetin on the expression of genes related to cell-cycle arrest, apoptosis and xenobiotic metabolism in human CO115 colon-adenocarcinoma cells using DNA microarray. PMID: 16640504 Ref: Colorectal cancer: genetics of development and metastasis. PMID: 16699851 Ref: SMAD4/DPC4 expression and prognosis in human colorectal cancer. PMID: 16739311 Ref: Bone morphogenetic protein signaling and growth suppression in colon cancer. PMID: 16769811 Ref: Genomic profiles of colorectal cancers differ based on patient smoking status. PMID: 16843098 Ref: c-Jun N-terminal kinase upregulation as a key event in the proapoptotic interaction between transforming growth factor-beta1 and 4-hydroxynonenal in colon mucosa. PMID: 16843825 Ref: Expression of Smad4 and TGF-beta2 in colorectal carcinoma. PMID: 16886611 Ref: Differential proteome analysis of colon carcinoma cell line SW480 after reconstitution of the tumour suppressor Smad4. PMID: 17043799 Ref: Chromosome 18q deletion and Smad4 protein inactivation correlate with liver metastasis: A study matched for T- and N- classification. PMID: 17088901 Ref: [Pancreatic cancer]. PMID: 17111879 Ref: Effect of DPC4 gene on invasion and metastasis of colorectal carcinoma cells. PMID: 17151782 Ref: Expression and mutation of SMAD4 in poorly differentiated carcinoma and signet-ring cell carcinoma of the colorectum. PMID: 17167985 Ref: [Developments in cancer management by innovative genomics. 2006 report of the National Cancer Consortium]. PMID: 17216011 |
Ref: Genetic alterations of the TGF-beta signaling pathway in colorectal cancer cell lines: a novel mutation in Smad3 associated with the inactivation of TGF-beta-induced transcriptional activation. PMID: 16828225 Ref: Colorectal cancer: potential therapeutic benefits of Vitamin D. PMID: 17157547 Ref: Expression of TGF-beta1, TbetaRII and Smad4 in colorectal carcinoma. PMID: 17289018 Ref: Smad4 regulates claudin-1 expression in a transforming growth factor-beta-independent manner in colon cancer cells. PMID: 17308096 Ref: [Colorectal carcinogenesis. 1. Hereditary predisposition and colorectal cancer]. PMID: 17369756 Ref: SMAD4-deficient intestinal tumors recruit CCR1+ myeloid cells that promote invasion. PMID: 17369830 Ref: Loss of Smad4 expression predicts liver metastasis in human colorectal cancer. PMID: 17390050 Ref: Genetic testing in colorectal cancer: who, when, how and why. PMID: 17392593 Ref: Proinvasive activity of BMP-7 through SMAD4/src-independent and ERK/Rac/JNK-dependent signaling pathways in colon cancer cells. PMID: 17478078 Ref: Pathogenesis of colorectal carcinoma and therapeutic implications: the roles of the ubiquitin-proteasome system and Cox-2. PMID: 17488476 Ref: TGF-beta receptor 2 downregulation in tumour-associated stroma worsens prognosis and high-grade tumours show more tumour-associated macrophages and lower TGF-beta1 expression in colon carcinoma: a retrospective study. PMID: 17692120 Ref: National study of colorectal cancer genetics. PMID: 17895893 Ref: The effect of statins in colorectal cancer is mediated through the bone morphogenetic protein pathway. PMID: 17919499 Ref: High-level inducible Smad4-reexpression in the cervical cancer cell line C4-II is associated with a gene expression profile that predicts a preferential role of Smad4 in extracellular matrix composition. PMID: 17997817 Ref: SNP-Array genotyping and spectral karyotyping reveal uniparental disomy as early mutational event in MSS- and MSI-colorectal cancer cell lines. PMID: 18000373 Ref: [Genetic profile and molecular bases of pancreatic carcinogenesis]. PMID: 18028855 Ref: BMP suppresses PTEN expression via RAS/ERK signaling. PMID: 18059158 |
Ref: Loss of Smad4 protein expression and 18qLOH as molecular markers indicating lymph node metastasis in colorectal cancer--a study matched for tumor depth and pathology. PMID: 17786972 Ref: The bone morphogenetic protein pathway is active in human colon adenomas and inactivated in colorectal cancer. PMID: 18008360 Ref: Promoter methylation correlates with reduced Smad4 expression in advanced prostate cancer. PMID: 18213629 Ref: Progression and tumor heterogeneity analysis in early rectal cancer. PMID: 18245538 Ref: Transforming growth factor beta suppresses beta-catenin/Wnt signaling and stimulates an adhesion response in human colon carcinoma cells in a Smad4/DPC4 independent manner. PMID: 18367323 Ref: Expression of Smad2 and Smad4 in cervical cancer: absent nuclear Smad4 expression correlates with poor survival. PMID: 18425078 Ref: Selective killing of Smad4-negative tumor cells via a designed repressor strategy. PMID: 18426856 Ref: The bone morphogenetic protein pathway is inactivated in the majority of sporadic colorectal cancers. PMID: 18471510 Ref: In vitro differential sensitivity of melanomas to phenothiazines is based on the presence of codon 600 BRAF mutation. PMID: 18524847 Ref: The ubiquitin-proteasome system in colorectal cancer. PMID: 18619533 Ref: TGFbeta modulates PTEN expression independently of SMAD signaling for growth proliferation in colon cancer cells. PMID: 18769113 Ref: Smad7 induces hepatic metastasis in colorectal cancer. PMID: 18781153 Ref: Integrating chromosomal aberrations and gene expression profiles to dissect rectal tumorigenesis. PMID: 18959792 |
Ref: Matrix metalloproteinase 7 is required for tumor formation, but dispensable for invasion and fibrosis in SMAD4-deficient intestinal adenocarcinomas. PMID: 19002110 Ref: Mutational profiling of cancer candidate genes in glioblastoma, melanoma and pancreatic carcinoma reveals a snapshot of their genomic landscapes. PMID: 19058223 Ref: A transposon-based genetic screen in mice identifies genes altered in colorectal cancer. PMID: 19251594 Ref: Identification and characterization of a novel anticancer agent with selectivity against deleted in pancreatic cancer locus 4 (DPC4)-deficient pancreatic and colon cancer cells. PMID: 19276868 Ref: Smad4 restoration leads to a suppression of Wnt/beta-catenin signaling activity and migration capacity in human colon carcinoma cells. PMID: 19284991 Ref: Overexpression of bone morphogenetic protein 4 enhances the invasiveness of Smad4-deficient human colorectal cancer cells. PMID: 19321257 Ref: Promoter CpG island hypermethylation- and H3K9me3 and H3K27me3-mediated epigenetic silencing targets the deleted in colon cancer (DCC) gene in colorectal carcinogenesis without affecting neighboring genes on chromosomal region 18q21. PMID: 19329758 Ref: ITF-2 is disrupted via allelic loss of chromosome 18q21, and ITF-2B expression is lost at the adenoma-carcinoma transition. PMID: 19394332 Ref: Colorectal carcinomas in MUTYH-associated polyposis display histopathological similarities to microsatellite unstable carcinomas. PMID: 19527492 Ref: RUNX3 inhibits cell proliferation and induces apoptosis by TGF-beta-dependent and -independent mechanisms in human colon carcinoma cells. PMID: 19571605 Ref: Promoter-wide analysis of Smad4 binding sites in human epithelial cells. PMID: 19686287 Ref: [Familial colorectal cancer type X: clinical, pathological and molecular characterization]. PMID: 19686620 Ref: Tissue biomarker development in a multicentre trial context: a feasibility study on the PETACC3 stage II and III colon cancer adjuvant treatment trial. PMID: 19690194 Ref: Capsule endoscopy for the small bowel in juvenile polyposis syndrome: a case series. PMID: 19816839 Ref: Chromosome 18q deletion as a novel molecular predictor for colorectal cancer with simultaneous hepatic metastasis. PMID: 19861895 Ref: New Therapeutics Targeting Colon Cancer Stem Cells. PMID: 20148131 Ref: Alteration of SMAD4 does not participate in tumorigenesis of adenoid cystic carcinoma of the salivary gland. PMID: 21475783 |
Ref: The role of SMAD4 in early-onset colorectal cancer. PMID: 19183329 Ref: Hereditary mixed polyposis syndrome due to a BMPR1A mutation. PMID: 19438883 Ref: Random DNA fragmentation allows detection of single-copy, single-exon alterations of copy number by oligonucleotide array CGH in clinical FFPE samples. PMID: 19875416 Ref: Antimetastatic role of Smad4 signaling in colorectal cancer. PMID: 19909744 Ref: Epithelial to mesenchymal transition is impaired in colon cancer cells with microsatellite instability. PMID: 20026115 Ref: Distinct genetic alterations in colorectal cancer. PMID: 20126641 Ref: Role of TGF-beta1, its receptor TGFbetaRII, and Smad proteins in the progression of colorectal cancer. PMID: 20165854 Ref: Assessment of SMAD4, p53, and Ki-67 alterations as a predictor of liver metastasis in human colorectal cancer. PMID: 20180078 Ref: Chemogenomic analysis identifies Macbecin II as a compound specific for SMAD4-negative colon cancer cells. PMID: 20331650 Ref: Role of RUNX3 in bone morphogenetic protein signaling in colorectal cancer. PMID: 20442291 Ref: Tgf-beta signaling alterations and colon cancer. PMID: 20517689 Ref: SMAD4--molecular gladiator of the TGF-beta signaling is trampled upon by mutational insufficiency in colorectal carcinoma of Kashmiri population: an analysis with relation to KRAS proto-oncogene. PMID: 20565773 Ref: Smad4 loss is associated with fewer S100A8-positive monocytes in colorectal tumors and attenuated response to S100A8 in colorectal and pancreatic cancer cells. PMID: 20622003 Ref: SMAD4 immunohistochemistry reflects genetic status in juvenile polyposis syndrome. PMID: 20682711 Ref: SMAD4 mediates mesenchymal-epithelial reversion in SW480 colon carcinoma cells. PMID: 20682989 Ref: Distinguishing between cancer driver and passenger gene alteration candidates via cross-species comparison: a pilot study. PMID: 20707908 Ref: Gene dysregulations driven by somatic copy number aberrations-biological and clinical implications in colon tumors: a paper from the 2009 William Beaumont Hospital Symposium on Molecular Pathology. PMID: 20709793 Ref: Proteomics of Smad4 regulated transforming growth factor-beta signalling in colon cancer cells. PMID: 20862427 |
Ref: Bone morphogenetic protein 4 induces differentiation of colorectal cancer stem cells and increases their response to chemotherapy in mice. PMID: 20951698 Ref: Structural and functional analysis of SMAD4 gene promoter in malignant pancreatic and colorectal tissues: detection of two novel polymorphic nucleotide repeats. PMID: 21036691 Ref: Expression analysis of proline rich 15 (Prr15) in mouse and human gastrointestinal tumors. PMID: 21061267 Ref: Genetic variation in the TGF-beta signaling pathway and colon and rectal cancer risk. PMID: 21068203 Ref: Smad4 inactivation promotes malignancy and drug resistance of colon cancer. PMID: 21245094 Ref: Molecular profiling of colon tumors: the search for clinically relevant biomarkers of progression, prognosis, therapeutics, and predisposition. PMID: 21347779 Ref: Genetic variation in the transforming growth factor-beta signaling pathway and survival after diagnosis with colon and rectal cancer. PMID: 21365634 Ref: Keratin 23, a novel DPC4/Smad4 target gene which binds 14-3-3epsilon. PMID: 21492476 Ref: Analysis of the role of the BMP7-Smad4-Id2 signaling pathway in SW480 colorectal carcinoma cells. PMID: 21523323 Ref: SMAD4 promoter hypermethylation in Kashmiri colorectal cancer cases. PMID: 21727743 Ref: Quantitative phosphoproteomics of transforming growth factor-beta signaling in colon cancer cells. PMID: 21751366 Ref: Roles of VEGF-C and Smad4 in the lymphangiogenesis, lymphatic metastasis, and prognosis in colon cancer. PMID: 21786062 Ref: Familial colorectal cancer type X syndrome: two distinct molecular entities? PMID: 21837511 Ref: Chromothripsis is a common mechanism driving genomic rearrangements in primary and metastatic colorectal cancer. PMID: 22014273 Ref: Smad4 may help to identify a subset of colorectal cancer patients with early recurrence after curative therapy. PMID: 22024061 Ref: Association of overexpression of TIF1gamma with colorectal carcinogenesis and advanced colorectal adenocarcinoma. PMID: 22046087 Ref: Novel tumor suppressive function of Smad4 in serum starvation-induced cell death through PAK1-PUMA pathway. PMID: 22130069 Ref: Juvenile polyposis syndrome. PMID: 22171123 |
Ref: Down-regulation of Smad4 enhances proliferation and invasion of colorectal carcinoma HCT116 cells and up-regulates Id2. PMID: 21956276 Ref: High SMAD4 levels appear in microsatellite instability and hypermethylated colon cancers, and indicate a better prognosis. PMID: 21964812 Ref: Smad4-mediated signaling inhibits intestinal neoplasia by inhibiting expression of beta-catenin. PMID: 22115830 Ref: Prognostic significance of transforming growth factor beta (TGF-beta) signaling axis molecules and E-cadherin in colorectal cancer. PMID: 22278155 Ref: Juvenile polyposis, hereditary hemorrhagic telangiectasia, and early onset colorectal cancer in patients with SMAD4 mutation. PMID: 22331366 Ref: Expression of Smad4, E-cadherin and beta-catenin in advanced colorectal cancer: a retrospective study. PMID: 22517699 Ref: Effects of activin and TGFbeta on p21 in colon cancer. PMID: 22761777 Ref: The prevalence of hereditary hemorrhagic telangiectasia in juvenile polyposis syndrome. PMID: 22810475 Ref: Comprehensive molecular characterization of human colon and rectal cancer. PMID: 22810696 Ref: A comprehensive characterization of genome-wide copy number aberrations in colorectal cancer reveals novel oncogenes and patterns of alterations. PMID: 22860045 Ref: Quantitative analysis of cancer-associated gene methylation connected to risk factors in Korean colorectal cancer patients. PMID: 22880157 Ref: Juvenile polyposis syndrome: a study of genotype, phenotype, and long-term outcome. PMID: 22965402 Ref: SMAD4 haploinsufficiency associates with augmented colonic inflammation in select humans and mice. PMID: 23090737 Ref: The real face of juvenile polyposis syndrome. PMID: 23205314 |
Ref: SMAD2, SMAD3 and SMAD4 mutations in colorectal cancer. PMID: 23139211 Ref: TGF-beta promotes colorectal cancer cell growth in vitro and in vivo. PMID: 23178467 Ref: Characterization of a membrane-active anti-tumor agent, UA8967. PMID: 23179338 Ref: The oncogenic role of microRNA-130a/301a/454 in human colorectal cancer via targeting Smad4 expression. PMID: 23393589 Ref: Evaluation of the prognostic value of pSMAD immunohistochemistry in colorectal cancer. PMID: 23426176 Ref: Analysis of genomic aberrations associated with the clinicopathological parameters of rectal cancer by arraybased comparative genomic hybridization. PMID: 23440507 Ref: Exome sequencing in diagnostic evaluation of colorectal cancer predisposition in young patients. PMID: 23544471 Ref: The role of a ginseng saponin metabolite as a DNA methyltransferase inhibitor in colorectal cancer cells. PMID: 23652987 Ref: S-adenosylmethionine, a methyl donor, up regulates tissue inhibitor of metalloproteinase-2 in colorectal cancer. PMID: 23661436 Ref: The density of macrophages in colorectal cancer is inversely correlated to TGF-beta1 expression and patients' survival. PMID: 23801404 Ref: Loss of SMAD4 from colorectal cancer cells promotes CCL15 expression to recruit CCR1+ myeloid cells and facilitate liver metastasis. PMID: 23891973 Ref: Colorectal cancer diagnostics: biomarkers, cell-free DNA, circulating tumor cells and defining heterogeneous populations by single-cell analysis. PMID: 23895128 Ref: MicroRNA-224 targets SMAD family member 4 to promote cell proliferation and negatively influence patient survival. PMID: 23922662 Ref: Reduced expression of bone morphogenetic protein receptor IA in pancreatic cancer is associated with a poor prognosis. PMID: 23969729 Ref: Effects of parafibromin expression on the phenotypes and relevant mechanisms in the DLD-1 colon carcinoma cell line. PMID: 23991985 Ref: Relationship of TGF-beta1 and Smad7 expression with decreased dendritic cell infiltration in liver gastrointestinal cancer metastasis. PMID: 23998914 Ref: Targeting the ERK pathway reduces liver metastasis of Smad4-inactivated colorectal cancer. PMID: 24025354 Ref: Up-regulation of miR-224 promotes cancer cell proliferation and invasion and predicts relapse of colorectal cancer. PMID: 24152489 Ref: A novel germline mutation in exon 10 of the SMAD4 gene in a familial juvenile polyposis. PMID: 24312718 |
Ref: Loss of Smad4 in colorectal cancer induces resistance to 5-fluorouracil through activating Akt pathway. PMID: 24384683 Ref: An integrative CGH, MSI and candidate genes methylation analysis of colorectal tumors. PMID: 24475022 Ref: Masking epistasis between MYC and TGF-beta pathways in antiangiogenesis-mediated colon cancer suppression. PMID: 24627270 Ref: Loss of SMAD4 alters BMP signaling to promote colorectal cancer cell metastasis via activation of Rho and ROCK. PMID: 24704720 Ref: Colorectal cancer risk and patients' survival: influence of polymorphisms in genes somatically mutated in colorectal tumors. PMID: 24706189 Ref: Loss of p15INK(4)b expression in colorectal cancer is linked to ethnic origin. PMID: 24716938 Ref: miR20a is an independent prognostic factor in colorectal cancer and is involved in cell metastasis. PMID: 24737193 Ref: Molecular and prognostic heterogeneity of microsatellite-unstable colorectal cancer. PMID: 24764661 Ref: MicroRNA-224 suppresses colorectal cancer cell migration by targeting Cdc42. PMID: 24817781 Ref: Synthetic triterpenoid induces 15-PGDH expression and suppresses inflammation-driven colon carcinogenesis. PMID: 24837432 Ref: Oncogenic transformation of diverse gastrointestinal tissues in primary organoid culture. PMID: 24859528 Ref: Multiple regression analysis of mRNA-miRNA associations in colorectal cancer pathway. PMID: 24895601 Ref: S-allylmercaptocysteine promotes MAPK inhibitor-induced apoptosis by activating the TGF-beta signaling pathway in cancer cells. PMID: 24970681 Ref: Identification of coding exon 3 duplication in the BMPR1A gene in a patient with juvenile polyposis syndrome. PMID: 25129392 Ref: Meta-analysis of the prognostic value of smad4 immunohistochemistry in various cancers. PMID: 25333693 Ref: [Juvenile polyposis syndrome and hereditary haemorrhagic telangiectasia syndrome in a patient a with SMAD4 mutation]. PMID: 25354002 Ref: Deletion and down-regulation of SMAD4 gene in colorectal cancers in a Chinese population. PMID: 25400417 |
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