Primary Site >> Biliary tract Cancer

Gene >> SMAD4

Journal: Cancer Res. 1998 Mar 15;58(6):1124-6.
Title: Mutations of the DPC4/Smad4 gene in biliary tract carcinoma.
Author: Hahn, S A|Bartsch, D|Schroers, A|Galehdari, H|Becker, M|Ramaswamy, A|Schwarte-Waldhoff, I|Maschek, H|Schmiegel, W
PMID: 9515793
Journal: Ann Oncol. 1999;10 Suppl 4:153-6.
Title: Biliopancreatic malignancy: screening the at risk patient with molecular markers.
Author: Caldas, C
PMID: 10436811
Journal: Int J Cancer. 2000 Jun 15;86(6):782-9.
Title: Disrupted transforming growth factor-beta signaling and deregulated growth in human biliary tract cancer cells.
Author: Yazumi, S|Ko, K|Watanabe, N|Shinohara, H|Yoshikawa, K|Chiba, T|Takahashi, R
PMID: 10842191
Journal: Br J Cancer. 2001 Jan;84(2):253-62.
Title: Pancreatic tumours: molecular pathways implicated in ductal cancer are involved in ampullary but not in exocrine nonductal or endocrine tumorigenesis.
Author: Moore, P S|Orlandini, S|Zamboni, G|Capelli, P|Rigaud, G|Falconi, M|Bassi, C|Lemoine, N R|Scarpa, A
PMID: 11161385
Journal: Cancer. 2001 Apr 1;91(7):1332-41.
Title: Differing rates of loss of DPC4 expression and of p53 overexpression among carcinomas of the proximal and distal bile ducts.
Author: Argani, P|Shaukat, A|Kaushal, M|Wilentz, R E|Su, G H|Sohn, T A|Yeo, C J|Cameron, J L|Kern, S E|Hruban, R H
PMID: 11283934
Journal: Anticancer Res. 2002 May-Jun;22(3):1529-36.
Title: Allelotype analysis of the PTEN, Smad4 and DCC genes in biliary tract cancer.
Author: Suto, Takayuki|Sugai, Tamotsu|Habano, Wataru|Uesugi, Noriyuki|Kanno, Senji|Saito, Kazuyoshi|Nakamura, Shin-ichi
PMID: 12168833
Journal: Hum Pathol. 2002 Sep;33(9):877-83.
Title: Expression of G1-S modulators (p53, p16, p27, cyclin D1, Rb) and Smad4/Dpc4 in intrahepatic cholangiocarcinoma.
Author: Kang, Yun Kyung|Kim, Woo Ho|Jang, Ja June
PMID: 12378511
Journal: Zhonghua Yu Fang Yi Xue Za Zhi. 2002 Dec;36(7):481-4.
Title: Frequency of loss expression of the DPC4 protein in various locations of biliary tract carcinoma.
Author: Tang, Zhaohui|Zou, Shengquan|Hao, Youhua|Wang, Baoju|Yang, Xiangping|Qiu, Fazu
PMID: 12411149
Journal: Surg Oncol Clin N Am. 2002 Oct;11(4):995-1009.
Title: Cellular and molecular biology of biliary tract cancers.
Author: Rashid, Asif
PMID: 12607585
Journal: Hepatobiliary Pancreat Dis Int. 2002 Nov;1(4):624-9.
Title: The relationship between loss expression of DPC4/Smad4 gene and carcinogenesis of pancreatobiliary carcinoma.
Author: Tang, Zhao-Hui|Zou, Sheng-Quan|Hao, You-Hua|Wang, Bao-Ju|Yang, Xiang-Ping|Chen, Qi-Qi|Qiu, Fa-Zu
PMID: 14607700
Journal: Mol Cancer. 2003 Jan 7;2:7.
Title: Genetic abnormalities in pancreatic cancer.
Author: Moore, Patrick S|Beghelli, Stefania|Zamboni, Giuseppe|Scarpa, Aldo
PMID: 12537585
Journal: Mod Pathol. 2003 Mar;16(3):272-8.
Title: Role of the DPC4 tumor suppressor gene in adenocarcinoma of the ampulla of Vater: analysis of 140 cases.
Author: McCarthy, Denis M|Hruban, Ralph H|Argani, Pedram|Howe, James R|Conlon, Kevin C|Brennan, Murray F|Zahurak, Marianna|Wilentz, Robb E|Cameron, John L|Yeo, Charles J|Kern, Scott E|Klimstra, David S
PMID: 12640108
Journal: Mod Pathol. 2003 Apr;16(4):299-308.
Title: Immunohistochemical and genetic analysis of non-small cell and small cell gallbladder carcinoma and their precursor lesions.
Author: Parwani, Anil V|Geradts, Joseph|Caspers, Eric|Offerhaus, G Johan|Yeo, Charles J|Cameron, John L|Klimstra, David S|Maitra, Anirban|Hruban, Ralph H|Argani, Pedram
PMID: 12692194
Journal: Hum Pathol. 2003 Sep;34(9):902-10.
Title: Molecular and immunohistochemical analysis of intraductal papillary neoplasms of the biliary tract.
Author: Abraham, Susan C|Lee, Jae-Hyuk|Hruban, Ralph H|Argani, Pedram|Furth, Emma E|Wu, Tsung-Teh
PMID: 14562286
Journal: Pathol Res Pract. 2004;200(1):1-7.
Title: Loss of SMAD4 function in small intestinal adenocarcinomas: comparison of genetic and immunohistochemical findings.
Author: Blaker, Hendrik|Aulmann, Sebastian|Helmchen, Birgit|Otto, Herwart F|Rieker, Ralf J|Penzel, Roland
PMID: 15157044
Journal: Zhonghua Wai Ke Za Zhi. 2005 Jul 1;43(13):846-9.
Title: [Expression of Smad4 and transforming growth factor-beta1, transforming growth factor-beta receptor II in cholangiocarcinoma tissue and its biological significance].
Author: Zhang, Bing-yuan|Zhang, Jian-yu|Zhao, Kai|Wu, Li-qun
PMID: 16083599
Journal: J Clin Invest. 2006 Jul;116(7):1843-52. Epub 2006 Jun 8.
Title: Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice.
Author: Xu, Xiaoling|Kobayashi, Shogo|Qiao, Wenhui|Li, Cuiling|Xiao, Cuiying|Radaeva, Svetlana|Stiles, Bangyan|Wang, Rui-Hong|Ohara, Nobuya|Yoshino, Tadashi|LeRoith, Derek|Torbenson, Michael S|Gores, Gregory J|Wu, Hong|Gao, Bin|Deng, Chu-Xia
PMID: 16767220
Journal: J Surg Oncol. 2006 Sep 15;94(4):338-43.
Title: Expression of DPC4/Smad4 gene in stone-containing intrahepatic bile duct.
Author: Lee, King-Teh|Chang, Wen-Tsan|Wang, Shen-Nien|Chuang, Shih-Chang|Chai, Chee-Yin|Hu, Shih-Wen
PMID: 16917866
Journal: Ann Surg Oncol. 2007 Mar;14(3):1200-11. Epub 2006 Dec 23.
Title: Bile duct cyst as precursor to biliary tract cancer.
Author: Soreide, Kjetil|Soreide, Jon Arne
PMID: 17187167
Journal: Cancer Sci. 2007 Jun;98(6):838-43.
Title: Restoration of RUNX3 enhances transforming growth factor-beta-dependent p21 expression in a biliary tract cancer cell line.
Author: Hasegawa, Kazunori|Yazumi, Shujiro|Wada, Manabu|Sakurai, Toshiharu|Kida, Masaya|Yamauchi, Junichi|Hisatsune, Hiroshi|Tada, Shinsuke|Ida, Hiroshi|Nakase, Yuenn|Sakakura, Chohei|Hagiwara, Akeo|Chiba, Tsutomu
PMID: 17470130
Journal: Pathol Oncol Res. 2007;13(4):326-35. Epub 2007 Dec 25.
Title: Significance of PML and p53 protein as molecular prognostic markers of gallbladder carcinomas.
Author: Chang, Hee Jin|Yoo, Byong Chul|Kim, Sun Whe|Lee, Byung Lan|Kim, Woo Ho
PMID: 18158568
Journal: Hum Pathol. 2008 Aug;39(8):1153-61.
Title: Expression of cell cycle-related molecules in biliary premalignant lesions: biliary intraepithelial neoplasia and biliary intraductal papillary neoplasm.
Author: Nakanishi, Yoshitsugu|Zen, Yoh|Kondo, Satoshi|Itoh, Tomoo|Itatsu, Keita|Nakanuma, Yasuni
PMID: 18495210
Journal: J Gastrointest Surg. 2008 Oct;12(10):1664-72; discussion 1672-3.
Title: Loss of heterozygosity predicts poor survival after resection of pancreatic adenocarcinoma.
Author: Franko, Jan|Krasinskas, Alyssa M|Nikiforova, Marina N|Zarnescu, Narcis O|Lee, Kenneth K W|Hughes, Steven J|Bartlett, David L|Zeh, Herbert J 3rd|Moser, A James
PMID: 18677542
Journal: Virchows Arch. 2010 Jun;456(6):711-7.
Title: Extensive biliary intraepithelial neoplasia (BilIN) and multifocal early intrahepatic cholangiocarcinoma in non-biliary cirrhosis.
Author: Rougemont, Anne-Laure|Genevay, Muriel|McKee, Thomas A|Gremaud, Magali|Mentha, Gilles|Rubbia-Brandt, Laura
PMID: 20428886
Journal: Hum Pathol. 2011 Jun;42(6):824-32.
Title: A comparative study of intraductal papillary neoplasia of the biliary tract and pancreas.
Author: Kloek, Jaap J|van der Gaag, Niels A|Erdogan, Deha|Rauws, Erik A J|Busch, Olivier R C|Gouma, Dirk J|ten Kate, Fiebo J W|van Gulik, Thomas M
PMID: 21292296
Journal: Am J Surg Pathol. 2012 Nov;36(11):1647-55.
Title: Intraductal tubular neoplasms of the bile ducts.
Author: Katabi, Nora|Torres, Javiera|Klimstra, David S
PMID: 23073323
Journal: Genome Med. 2012 Jul 4;4(7):56.
Title: Cancer of the ampulla of Vater: analysis of the whole genome sequence exposes a potential therapeutic vulnerability.
Author: Demeure, Michael J|Craig, David W|Sinari, Shripad|Moses, Tracy M|Christoforides, Alexis|Dinh, Jennifer|Izatt, Tyler|Aldrich, Jessica|Decker, Ardis|Baker, Angela|Cherni, Irene|Watanabe, April|Koep, Lawrence|Lake, Douglas|Hostetter, Galen|Trent, Jeffrey M|V
PMID: 22762308
Journal: Nat Genet. 2012 May 6;44(6):690-3.
Title: Exome sequencing of liver fluke-associated cholangiocarcinoma.
Author: Ong, Choon Kiat|Subimerb, Chutima|Pairojkul, Chawalit|Wongkham, Sopit|Cutcutache, Ioana|Yu, Willie|McPherson, John R|Allen, George E|Ng, Cedric Chuan Young|Wong, Bernice Huimin|Myint, Swe Swe|Rajasegaran, Vikneswari|Heng, Hong Lee|Gan, Anna|Zang, Zhi Jian
PMID: 22561520
Journal: Eur J Cancer. 2013 May;49(7):1725-40.
Title: Role of crosstalk between interleukin-6 and transforming growth factor-beta 1 in epithelial-mesenchymal transition and chemoresistance in biliary tract cancer.
Author: Yamada, Daisaku|Kobayashi, Shogo|Wada, Hiroshi|Kawamoto, Koichi|Marubashi, Shigeru|Eguchi, Hidetoshi|Ishii, Hideshi|Nagano, Hiroaki|Doki, Yuichiro|Mori, Masaki
PMID: 23298711
Journal: Chin Med J (Engl). 2013 Aug;126(16):3039-43.
Title: Inactivation of Smad4 is a prognostic factor in intrahepatic cholangiocarcinoma.
Author: Yan, Xue-qiang|Zhang, Wei|Zhang, Bi-xiang|Liang, Hui-fang|Zhang, Wan-guang|Chen, Xiao-ping
PMID: 23981608
Journal: Mol Med Rep. 2013 Dec;8(6):1623-9.
Title: JNK inhibitor SP600125 enhances TGF-beta-induced apoptosis of RBE human cholangiocarcinoma cells in a Smad-dependent manner.
Author: Lin, Youzhi|Zhang, Binhao|Liang, Huifang|Lu, Yulei|Ai, Xi|Zhang, Bixiang|Chen, Xiaoping
PMID: 24100678
Journal: Mod Pathol. 2014 Jan;27(1):73-86.
Title: Intraductal papillary neoplasms of the bile duct: stepwise progression to carcinoma involves common molecular pathways.
Author: Schlitter, Anna Melissa|Born, Diana|Bettstetter, Marcus|Specht, Katja|Kim-Fuchs, Corina|Riener, Marc-Oliver|Jeliazkova, Petia|Sipos, Bence|Siveke, Jens T|Terris, Benoit|Zen, Yoh|Schuster, Tibor|Hofler, Heinz|Perren, Aurel|Kloppel, Gunter|Esposito, Irene
PMID: 23828315
Journal: Mod Pathol. 2014 May;27(5):665-74.
Title: Epidermal growth factor receptor signaling pathway is frequently altered in ampullary carcinoma at protein and genetic levels.
Author: Mikhitarian, Kaidi|Pollen, Maressa|Zhao, Zhiguo|Shyr, Yu|Merchant, Nipun B|Parikh, Alexander|Revetta, Frank|Washington, M Kay|Vnencak-Jones, Cindy|Shi, Chanjuan
PMID: 24186143
Journal: J Hepatobiliary Pancreat Sci. 2014 Jun;21(6):380-7.
Title: Genomic and transcriptional alterations of cholangiocarcinoma.
Author: Ito, Takeshi|Sakurai-Yageta, Mika|Goto, Akiteru|Pairojkul, Chawalit|Yongvanit, Puangrat|Murakami, Yoshinori
PMID: 24532422
Journal: PLoS One. 2014 Dec 23;9(12):e115383.
Title: Mutation profiling in cholangiocarcinoma: prognostic and therapeutic implications.
Author: Churi, Chaitanya R|Shroff, Rachna|Wang, Ying|Rashid, Asif|Kang, HyunSeon C|Weatherly, Jacqueline|Zuo, Mingxin|Zinner, Ralph|Hong, David|Meric-Bernstam, Funda|Janku, Filip|Crane, Christopher H|Mishra, Lopa|Vauthey, Jean-Nicholas|Wolff, Robert A|Mills, Gord
PMID: 25536104
Journal: Best Pract Res Clin Gastroenterol. 2015 Apr;29(2):233-44.
Title: Pathogenesis of cholangiocarcinoma: From genetics to signalling pathways.
Author: Kongpetch, Sarinya|Jusakul, Apinya|Ong, Choon Kiat|Lim, Weng Khong|Rozen, Steven G|Tan, Patrick|Teh, Bin Tean
PMID: 25966424
Journal: BMC Cancer. 2015 Jun 16;15:469.
Title: microRNA-34a inhibits epithelial mesenchymal transition in human cholangiocarcinoma by targeting Smad4 through transforming growth factor-beta/Smad pathway.
Author: Qiao, Pengfei|Li, Guodong|Bi, Wen|Yang, Lianmeng|Yao, Lei|Wu, Dequan
PMID: 26077733
Journal: Mod Pathol. 2015 Sep;28(9):1249-64.
Title: Intraductal tubulopapillary neoplasms of the bile ducts: clinicopathologic, immunohistochemical, and molecular analysis of 20 cases.
Author: Schlitter, Anna Melissa|Jang, Kee-Taek|Kloppel, Gunter|Saka, Burcu|Hong, Seung-Mo|Choi, Hyejeong|Offerhaus, George Johan|Hruban, Ralph H|Zen, Yoh|Konukiewitz, Bjorn|Regel, Ivonne|Allgauer, Michael|Balci, Serdar|Basturk, Olca|Reid, Michelle D|Esposito, Ire
PMID: 26111977
Journal: Oncotarget. 2016 Apr 26;7(17):23825-36.
Title: Two classes of intrahepatic cholangiocarcinoma defined by relative abundance of mutations and copy number alterations.
Author: Kim, Young-Ho|Hong, Eun-Kyung|Kong, Sun-Young|Han, Sung-Sik|Kim, Seoung-Hoon|Rhee, Je-Keun|Hwang, Soo-Kyung|Park, Sang-Jae|Kim, Tae-Min
PMID: 27009864
Journal: J Gastrointest Oncol. 2016 Dec;7(6):974-981.
Title: Clinical, morphologic, and immunophenotypic characteristics of ampullary carcinomas with an emphasis on SMAD4 expression.
Author: Alkhasawneh, Ahmad|Duckworth, Lizette Vila|George, Thomas J|Desai, Neelam V|Sommerfeld, Alex J|Lu, Xiaomin|Toro, Tania Zuluaga
PMID: 28078121
Journal: Cancer. 2016 Dec 15;122(24):3838-3847.
Title: Biliary cancer: Utility of next-generation sequencing for clinical management.
Author: Javle, Milind|Bekaii-Saab, Tanios|Jain, Apurva|Wang, Ying|Kelley, Robin Katie|Wang, Kai|Kang, Hyunseon C|Catenacci, Daniel|Ali, Siraj|Krishnan, Sunil|Ahn, Daniel|Bocobo, Andrea Grace|Zuo, Mingxin|Kaseb, Ahmed|Miller, Vincent|Stephens, Philip J|Meric-Berns
PMID: 27622582
Journal: PLoS One. 2016 Jan 4;11(1):e0145985.
Title: A Histone Deacetylase Inhibitor Suppresses Epithelial-Mesenchymal Transition and Attenuates Chemoresistance in Biliary Tract Cancer.
Author: Sakamoto, Takuya|Kobayashi, Shogo|Yamada, Daisaku|Nagano, Hiroaki|Tomokuni, Akira|Tomimaru, Yoshito|Noda, Takehiro|Gotoh, Kunihito|Asaoka, Tadafumi|Wada, Hiroshi|Kawamoto, Koichi|Marubashi, Shigeru|Eguchi, Hidetoshi|Doki, Yuichiro|Mori, Masaki
PMID: 26726879
Journal: Mod Pathol. 2017 Jul;30(7):986-997.
Title: Dichotomy in intrahepatic cholangiocarcinomas based on histologic similarities to hilar cholangiocarcinomas.
Author: Akita, Masayuki|Fujikura, Kohei|Ajiki, Tetsuo|Fukumoto, Takumi|Otani, Kyoko|Azuma, Takeshi|Itoh, Tomoo|Ku, Yonson|Zen, Yoh
PMID: 28338651
Journal: Oncol Lett. 2017 Jul;14(1):877-884.
Title: Genetic alterations in Japanese extrahepatic biliary tract cancer.
Author: Noguchi, Rei|Yamaguchi, Kiyoshi|Ikenoue, Tsuneo|Terakado, Yumi|Ohta, Yasunori|Yamashita, Naohide|Kainuma, Osamu|Yokoi, Sana|Maru, Yoshiaki|Nagase, Hiroki|Furukawa, Yoichi
PMID: 28693246
Journal: Cancer Genomics Proteomics. 2017 Nov-Dec;14(6):495-506.
Title: Targeted Gene Sequencing of Gallbladder Carcinoma Identifies High-impact Somatic and Rare Germline Mutations.
Author: Yadav, Saurabh|DE Sarkar, Navonil|Kumari, Niraj|Krishnani, Narendra|Kumar, Ashok|Mittal, Balraj
PMID: 29109099
Journal: Dig Surg. 2018;35(2):116-120.
Title: Clinicopathologic Study of Biliary Intraepithelial Neoplasia in Cholangiocarcinoma.
Author: Kim, Hyo Jung|Kim, Jae Seon|Kim, Baek Hee|Bak, Young-Tae
PMID: 28490009
Journal: Am J Surg Pathol. 2018 Apr;42(4):512-521.
Title: MDM2 Amplification in Intrahepatic Cholangiocarcinomas: Its Relationship With Large-Duct Type Morphology and Uncommon KRAS Mutations.
Author: Kim, Sung Joo|Akita, Masayuki|Sung, You-Na|Fujikura, Kohei|Lee, Jae Hoon|Hwang, Shin|Yu, Eunsil|Otani, Kyoko|Hong, Seung-Mo|Zen, Yoh
PMID: 29309301
Journal: J Hepatol. 2018 May;68(5):959-969.
Title: Genomic characterization of biliary tract cancers identifies driver genes and predisposing mutations.
Author: Wardell, Christopher P|Fujita, Masashi|Yamada, Toru|Simbolo, Michele|Fassan, Matteo|Karlic, Rosa|Polak, Paz|Kim, Jaegil|Hatanaka, Yutaka|Maejima, Kazuhiro|Lawlor, Rita T|Nakanishi, Yoshitsugu|Mitsuhashi, Tomoko|Fujimoto, Akihiro|Furuta, Mayuko|Ruzzenente,
PMID: 29360550
Journal: Cancer Sci. 2018 May;109(5):1282-1291.
Title: Molecular genomic landscapes of hepatobiliary cancer.
Author: Shibata, Tatsuhiro|Arai, Yasuhito|Totoki, Yasushi
PMID: 29573058
Journal: Hum Pathol. 2018 Aug;78:131-137.
Title: Mucinous intrahepatic cholangiocarcinoma: a distinct variant.
Author: Chi, Zhikai|Bhalla, Amarpreet|Saeed, Omer|Cheng, Liang|Curless, Kendra|Wang, Hanlin L|Patil, Deepa T|Lin, Jingmei
PMID: 29698701
Journal: Mutat Res. 2018 Apr - Jun;776:10-22.
Title: Ampullary carcinoma-A genetic perspective.
Author: Jayaramayya, Kaavya|Balachandar, Vellingiri|Santhy, Kumaran Sivanandan
PMID: 29807574
Journal: HPB (Oxford). 2018 Aug 28. pii: S1365-182X(18)32708-4.
Title: Histological and molecular characterization of intrahepatic bile duct cancers suggests an expanded definition of perihilar cholangiocarcinoma.
Author: Akita, Masayuki|Sofue, Keitaro|Fujikura, Kohei|Otani, Kyoko|Itoh, Tomoo|Ajiki, Tetsuo|Fukumoto, Takumi|Zen, Yoh
PMID: 30170977