Primary Site >> Biliary tract Cancer
Gene >> SMAD4
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Ref: Mutations of the DPC4/Smad4 gene in biliary tract carcinoma. PMID: 9515793 |
Ref: Biliopancreatic malignancy: screening the at risk patient with molecular markers. PMID: 10436811 |
Ref: Disrupted transforming growth factor-beta signaling and deregulated growth in human biliary tract cancer cells. PMID: 10842191 |
Ref: Pancreatic tumours: molecular pathways implicated in ductal cancer are involved in ampullary but not in exocrine nonductal or endocrine tumorigenesis. PMID: 11161385 Ref: Differing rates of loss of DPC4 expression and of p53 overexpression among carcinomas of the proximal and distal bile ducts. PMID: 11283934 |
Ref: Allelotype analysis of the PTEN, Smad4 and DCC genes in biliary tract cancer. PMID: 12168833 Ref: Expression of G1-S modulators (p53, p16, p27, cyclin D1, Rb) and Smad4/Dpc4 in intrahepatic cholangiocarcinoma. PMID: 12378511 Ref: Frequency of loss expression of the DPC4 protein in various locations of biliary tract carcinoma. PMID: 12411149 Ref: Cellular and molecular biology of biliary tract cancers. PMID: 12607585 Ref: The relationship between loss expression of DPC4/Smad4 gene and carcinogenesis of pancreatobiliary carcinoma. PMID: 14607700 |
Ref: Genetic abnormalities in pancreatic cancer. PMID: 12537585 Ref: Role of the DPC4 tumor suppressor gene in adenocarcinoma of the ampulla of Vater: analysis of 140 cases. PMID: 12640108 Ref: Immunohistochemical and genetic analysis of non-small cell and small cell gallbladder carcinoma and their precursor lesions. PMID: 12692194 Ref: Molecular and immunohistochemical analysis of intraductal papillary neoplasms of the biliary tract. PMID: 14562286 |
Ref: Loss of SMAD4 function in small intestinal adenocarcinomas: comparison of genetic and immunohistochemical findings. PMID: 15157044 |
Ref: [Expression of Smad4 and transforming growth factor-beta1, transforming growth factor-beta receptor II in cholangiocarcinoma tissue and its biological significance]. PMID: 16083599 |
Ref: Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice. PMID: 16767220 Ref: Expression of DPC4/Smad4 gene in stone-containing intrahepatic bile duct. PMID: 16917866 |
Ref: Bile duct cyst as precursor to biliary tract cancer. PMID: 17187167 Ref: Restoration of RUNX3 enhances transforming growth factor-beta-dependent p21 expression in a biliary tract cancer cell line. PMID: 17470130 Ref: Significance of PML and p53 protein as molecular prognostic markers of gallbladder carcinomas. PMID: 18158568 |
Ref: Expression of cell cycle-related molecules in biliary premalignant lesions: biliary intraepithelial neoplasia and biliary intraductal papillary neoplasm. PMID: 18495210 Ref: Loss of heterozygosity predicts poor survival after resection of pancreatic adenocarcinoma. PMID: 18677542 |
Ref: Extensive biliary intraepithelial neoplasia (BilIN) and multifocal early intrahepatic cholangiocarcinoma in non-biliary cirrhosis. PMID: 20428886 |
Ref: A comparative study of intraductal papillary neoplasia of the biliary tract and pancreas. PMID: 21292296 |
Ref: Exome sequencing of liver fluke-associated cholangiocarcinoma. PMID: 22561520 Ref: Cancer of the ampulla of Vater: analysis of the whole genome sequence exposes a potential therapeutic vulnerability. PMID: 22762308 Ref: Intraductal tubular neoplasms of the bile ducts. PMID: 23073323 |
Ref: Role of crosstalk between interleukin-6 and transforming growth factor-beta 1 in epithelial-mesenchymal transition and chemoresistance in biliary tract cancer. PMID: 23298711 Ref: Inactivation of Smad4 is a prognostic factor in intrahepatic cholangiocarcinoma. PMID: 23981608 Ref: JNK inhibitor SP600125 enhances TGF-beta-induced apoptosis of RBE human cholangiocarcinoma cells in a Smad-dependent manner. PMID: 24100678 |
Ref: Intraductal papillary neoplasms of the bile duct: stepwise progression to carcinoma involves common molecular pathways. PMID: 23828315 Ref: Epidermal growth factor receptor signaling pathway is frequently altered in ampullary carcinoma at protein and genetic levels. PMID: 24186143 Ref: Genomic and transcriptional alterations of cholangiocarcinoma. PMID: 24532422 Ref: Mutation profiling in cholangiocarcinoma: prognostic and therapeutic implications. PMID: 25536104 |
Ref: Pathogenesis of cholangiocarcinoma: From genetics to signalling pathways. PMID: 25966424 Ref: microRNA-34a inhibits epithelial mesenchymal transition in human cholangiocarcinoma by targeting Smad4 through transforming growth factor-beta/Smad pathway. PMID: 26077733 Ref: Intraductal tubulopapillary neoplasms of the bile ducts: clinicopathologic, immunohistochemical, and molecular analysis of 20 cases. PMID: 26111977 |
Ref: A Histone Deacetylase Inhibitor Suppresses Epithelial-Mesenchymal Transition and Attenuates Chemoresistance in Biliary Tract Cancer. PMID: 26726879 Ref: Two classes of intrahepatic cholangiocarcinoma defined by relative abundance of mutations and copy number alterations. PMID: 27009864 Ref: Biliary cancer: Utility of next-generation sequencing for clinical management. PMID: 27622582 Ref: Clinical, morphologic, and immunophenotypic characteristics of ampullary carcinomas with an emphasis on SMAD4 expression. PMID: 28078121 |
Ref: Dichotomy in intrahepatic cholangiocarcinomas based on histologic similarities to hilar cholangiocarcinomas. PMID: 28338651 Ref: Genetic alterations in Japanese extrahepatic biliary tract cancer. PMID: 28693246 Ref: Targeted Gene Sequencing of Gallbladder Carcinoma Identifies High-impact Somatic and Rare Germline Mutations. PMID: 29109099 |
Ref: Clinicopathologic Study of Biliary Intraepithelial Neoplasia in Cholangiocarcinoma. PMID: 28490009 Ref: MDM2 Amplification in Intrahepatic Cholangiocarcinomas: Its Relationship With Large-Duct Type Morphology and Uncommon KRAS Mutations. PMID: 29309301 Ref: Genomic characterization of biliary tract cancers identifies driver genes and predisposing mutations. PMID: 29360550 Ref: Molecular genomic landscapes of hepatobiliary cancer. PMID: 29573058 Ref: Mucinous intrahepatic cholangiocarcinoma: a distinct variant. PMID: 29698701 Ref: Ampullary carcinoma-A genetic perspective. PMID: 29807574 Ref: Histological and molecular characterization of intrahepatic bile duct cancers suggests an expanded definition of perihilar cholangiocarcinoma. PMID: 30170977 |