Literatures

Primary Site >> Colorectal Cancer

Gene >> SMAD3

1.
Journal:	Cell. 1998 Sep 18;94(6):703-14.
Title:	Smad3 mutant mice develop metastatic colorectal cancer.
Author:	Zhu, Y\|Richardson, J A\|Parada, L F\|Graff, J M
PMID:	9753318

2.
Journal:	Cancer Lett. 1998 Jan 9;122(1-2):157-63.
Title:	Genomic structure of the human Smad3 gene and its infrequent alterations in colorectal cancers.
Author:	Arai, T\|Akiyama, Y\|Okabe, S\|Ando, M\|Endo, M\|Yuasa, Y
PMID:	9464505

3.
Journal:	Int J Cancer. 1999 Jul 19;82(2):197-202.
Title:	Expression of Smad proteins in human colorectal cancer.
Author:	Korchynskyi, O\|Landstrom, M\|Stoika, R\|Funa, K\|Heldin, C H\|ten Dijke, P\|Souchelnytskyi, S
PMID:	10389752

4.
Journal:	Oncogene. 1999 May 20;18(20):3098-103.
Title:	Higher frequency of Smad4 gene mutation in human colorectal cancer with distant metastasis.
Author:	Miyaki, M\|Iijima, T\|Konishi, M\|Sakai, K\|Ishii, A\|Yasuno, M\|Hishima, T\|Koike, M\|Shitara, N\|Iwama, T\|Utsunomiya, J\|Kuroki, T\|Mori, T
PMID:	10340381

5.
Journal:	J Biol Chem. 1999 Nov 19;274(47):33637-43.
Title:	Smad4/DPC4 silencing and hyperactive Ras jointly disrupt transforming growth factor-beta antiproliferative responses in colon cancer cells.
Author:	Calonge, M J\|Massague, J
PMID:	10559252

6.
Journal:	Gut. 1999 Sep;45(3):406-8.
Title:	Screening SMAD1, SMAD2, SMAD3, and SMAD5 for germline mutations in juvenile polyposis syndrome.
Author:	Bevan, S\|Woodford-Richens, K\|Rozen, P\|Eng, C\|Young, J\|Dunlop, M\|Neale, K\|Phillips, R\|Markie, D\|Rodriguez-Bigas, M\|Leggett, B\|Sheridan, E\|Hodgson, S\|Iwama, T\|Eccles, D\|Bodmer, W\|Houlston, R\|Tomlinson, I
PMID:	10446110

7.
Journal:	Mol Carcinog. 2001 Aug;31(4):204-13.
Title:	Aberrant transforming growth factor-beta signaling in azoxymethane-induced mouse colon tumors.
Author:	Guda, K\|Giardina, C\|Nambiar, P\|Cui, H\|Rosenberg, D W
PMID:	11536370

8.
Journal:	Cancer Cell. 2002 May;1(4):355-68.
Title:	Pathway-specific tumor suppression. Reduction of p27 accelerates gastrointestinal tumorigenesis in Apc mutant mice, but not in Smad3 mutant mice.
Author:	Philipp-Staheli, Jeannette\|Kim, Kyung-Hoon\|Payne, Shannon R\|Gurley, Kay E\|Liggitt, Denny\|Longton, Gary\|Kemp, Christopher J
PMID:	12086850

9.
Journal:	Mol Cell Endocrinol. 2002 Jul 31;193(1-2):109-20.
Title:	The androgen receptor CAG repeat: a modifier of carcinogenesis?
Author:	Ferro, Paola\|Catalano, Maria G\|Dell'Eva, Raffaella\|Fortunati, Nicoletta\|Pfeffer, Ulrich
PMID:	12161010

10.
Journal:	Biochem J. 2003 Apr 1;371(Pt 1):211-21.
Title:	Converging signals synergistically activate the LAMC2 promoter and lead to accumulation of the laminin gamma 2 chain in human colon carcinoma cells.
Author:	Olsen, Jorgen\|Kirkeby, Lene T\|Brorsson, Marianne M\|Dabelsteen, Sally\|Troelsen, Jesper T\|Bordoy, Randi\|Fenger, Kirsten\|Larsson, Lars-Inge\|Simon-Assmann, Patricia
PMID:	12519076

11.
Journal:	Oncogene. 2003 Mar 6;22(9):1317-23.
Title:	TGF-beta-induced nuclear localization of Smad2 and Smad3 in Smad4 null cancer cell lines.
Author:	Fink, Stephen P\|Mikkola, Debra\|Willson, James K V\|Markowitz, Sanford
PMID:	12618756

12.
Journal:	J Exp Clin Cancer Res. 2003 Jun;22(2):315-20.
Title:	Mutational analysis of TGF-beta type II receptor, Smad2, Smad3, Smad4, Smad6 and Smad7 genes in colorectal cancer.
Author:	Fukushima, T\|Mashiko, M\|Takita, K\|Otake, T\|Endo, Y\|Sekikawa, K\|Takenoshita, S
PMID:	12866583

13.
Journal:	Biochem J. 2004 Apr 1;379(Pt 1):209-16.
Title:	Molecular and functional consequences of Smad4 C-terminal missense mutations in colorectal tumour cells.
Author:	De Bosscher, Karolien\|Hill, Caroline S\|Nicolas, Francisco J
PMID:	14715079

14.
Journal:	Cancer Sci. 2004 Jan;95(1):12-7.
Title:	Transforming growth factor-beta signaling is differentially inhibited by Smad2D450E and Smad3D407E.
Author:	Kondo, Miki\|Suzuki, Hiroyuki\|Takehara, Kazuhiko\|Miyazono, Kohei\|Kato, Mitsuyasu
PMID:	14720321

15.
Journal:	World J Surg. 2005 Mar;29(3):306-11.
Title:	TGF-beta signaling in colon cancer cells.
Author:	Li, Fazhi\|Cao, Yanna\|Townsend, Courtney M Jr\|Ko, Tien C
PMID:	15711891

16.
Journal:	Mol Cell Biol. 2005 Sep;25(18):8108-25.
Title:	Smad4 dependency defines two classes of transforming growth factor {beta} (TGF-{beta}) target genes and distinguishes TGF-{beta}-induced epithelial-mesenchymal transition from its antiproliferative and migratory responses.
Author:	Levy, Laurence\|Hill, Caroline S
PMID:	16135802

17.
Journal:	Biochem Biophys Res Commun. 2005 Aug 5;333(3):827-32.
Title:	Inhibitory effect of genistein on mouse colon cancer MC-26 cells involved TGF-beta1/Smad pathway.
Author:	Yu, Zengli\|Tang, Yunan\|Hu, Dongsheng\|Li, Juan
PMID:	15963949

18.
Journal:	Cancer Res. 2005 Jan 1;65(1):157-65.
Title:	Acceleration of Smad2 and Smad3 phosphorylation via c-Jun NH(2)-terminal kinase during human colorectal carcinogenesis.
Author:	Yamagata, Hideo\|Matsuzaki, Koichi\|Mori, Shigeo\|Yoshida, Katsunori\|Tahashi, Yoshiya\|Furukawa, Fukiko\|Sekimoto, Go\|Watanabe, Toshihiko\|Uemura, Yoshiko\|Sakaida, Noriko\|Yoshioka, Kazuhiko\|Kamiyama, Yasuo\|Seki, Toshihito\|Okazaki, Kazuichi
PMID:	15665291

19.
Journal:	Cancer Res. 2006 Jan 15;66(2):828-38.
Title:	Helicobacter infection is required for inflammation and colon cancer in SMAD3-deficient mice.
Author:	Maggio-Price, Lillian\|Treuting, Piper\|Zeng, Weiping\|Tsang, Mark\|Bielefeldt-Ohmann, Helle\|Iritani, Brian M
PMID:	16424015

20.
Journal:	Oncogene. 2006 Jun 15;25(25):3565-75. Epub 2006 Feb 6.
Title:	Evi1 is a survival factor which conveys resistance to both TGFbeta- and taxol-mediated cell death via PI3K/AKT.
Author:	Liu, Y\|Chen, L\|Ko, T C\|Fields, A P\|Thompson, E A
PMID:	16462766

21.
Journal:	Histol Histopathol. 2006 Jun;21(6):645-62.
Title:	Smad3 phosphoisoform-mediated signaling during sporadic human colorectal carcinogenesis.
Author:	Matsuzaki, K
PMID:	16528675

22.
Journal:	Ann Surg. 2006 May;243(5):619-25; discussion 625-7.
Title:	Dietary fiber enhances a tumor suppressor signaling pathway in the gut.
Author:	Nguyen, Khoa A\|Cao, Yanna\|Chen, Justin R\|Townsend, Courtney M Jr\|Ko, Tien C
PMID:	16632996

23.
Journal:	Cancer Res. 2006 Sep 1;66(17):8430-8.
Title:	Smad3 deficiency promotes tumorigenesis in the distal colon of ApcMin/+ mice.
Author:	Sodir, Nicole M\|Chen, Xuan\|Park, Ryan\|Nickel, Andrea E\|Conti, Peter S\|Moats, Rex\|Bading, James R\|Shibata, Darryl\|Laird, Peter W
PMID:	16951153

24.
Journal:	Inflammopharmacology. 2006 Dec;14(5-6):198-203.
Title:	TGF-beta during human colorectal carcinogenesis: the shift from epithelial to mesenchymal signaling.
Author:	Matsuzaki, K\|Seki, T\|Okazaki, K
PMID:	17093904

25.
Journal:	J Nutr. 2007 Nov;137(11 Suppl):2576S-2579S.
Title:	Dietary modulation of colon cancer risk.
Author:	Kim, Young S\|Milner, John A
PMID:	17951506

26.
Journal:	Tumour Biol. 2007;28(2):77-83. Epub 2007 Jan 29.
Title:	Cell surface fucosylation does not affect development of colon tumors in mice with germline Smad3 mutation.
Author:	Domino, Steven E\|Karnak, David M\|Hurd, Elizabeth A
PMID:	17264540

27.
Journal:	Cancer Lett. 2007 Mar 18;247(2):283-92. Epub 2006 Jul 7.
Title:	Genetic alterations of the TGF-beta signaling pathway in colorectal cancer cell lines: a novel mutation in Smad3 associated with the inactivation of TGF-beta-induced transcriptional activation.
Author:	Ku, Ja-Lok\|Park, Seok-Hee\|Yoon, Kyong-Ah\|Shin, Young-Kyoung\|Kim, Kyung-Hee\|Choi, Jin-Sung\|Kang, Hio-Chung\|Kim, Il-Jin\|Han, Inn-Oc\|Park, Jae-Gahb
PMID:	16828225

28.
Journal:	Mol Cancer Res. 2007 Apr;5(4):341-9.
Title:	Targeted imaging of colonic tumors in smad3-/- mice discriminates cancer and inflammation.
Author:	Deane, Natasha G\|Manning, H Charles\|Foutch, A Coe\|Washington, M Kay\|Aronow, Bruce J\|Bornhop, Darryl J\|Coffey, Robert J
PMID:	17426249

29.
Journal:	Int J Oncol. 2008 Jun;32(6):1221-6.
Title:	Involvement of Smad3 phosphoisoform-mediated signaling in the development of colonic cancer in IL-10-deficient mice.
Author:	Hachimine, Daisaku\|Uchida, Kazushige\|Asada, Masanori\|Nishio, Akiyoshi\|Kawamata, Seiji\|Sekimoto, Go\|Murata, Miki\|Yamagata, Hideo\|Yoshida, Katsunori\|Mori, Shigeo\|Tahashi, Yoshiya\|Matsuzaki, Koichi\|Okazaki, Kazuichi
PMID:	18497983

30.
Journal:	Cancer Biol Ther. 2008 Oct;7(10):1694-9. Epub 2008 Oct 22.
Title:	TGFbeta modulates PTEN expression independently of SMAD signaling for growth proliferation in colon cancer cells.
Author:	Chow, Jimmy Y C\|Cabral, Jennifer A\|Chang, Jessica\|Carethers, John M
PMID:	18769113

31.
Journal:	Am J Pathol. 2009 Jan;174(1):317-29.
Title:	Bacterial infection of Smad3/Rag2 double-null mice with transforming growth factor-beta dysregulation as a model for studying inflammation-associated colon cancer.
Author:	Maggio-Price, Lillian\|Treuting, Piper\|Bielefeldt-Ohmann, Helle\|Seamons, Audrey\|Drivdahl, Rolf\|Zeng, Weiping\|Lai, LapHin\|Huycke, Mark\|Phelps, Susan\|Brabb, Thea\|Iritani, Brian M
PMID:	19119184

32.
Journal:	Cancer Res. 2009 Jan 15;69(2):678-86.
Title:	Tgfbr1 haploinsufficiency is a potent modifier of colorectal cancer development.
Author:	Zeng, Qinghua\|Phukan, Sharbani\|Xu, Yanfei\|Sadim, Maureen\|Rosman, Diana S\|Pennison, Michael\|Liao, Jie\|Yang, Guang-Yu\|Huang, Chiang-Ching\|Valle, Laura\|Di Cristofano, Antonio\|de la Chapelle, Albert\|Pasche, Boris
PMID:	19147584

33.
Journal:	J Biol Chem. 2009 May 8;284(19):13033-44.
Title:	The F-box protein beta-TrCp1/Fbw1a interacts with p300 to enhance beta-catenin transcriptional activity.
Author:	Kimbrel, Erin A\|Kung, Andrew L
PMID:	19297328

34.
Journal:	Cancer Res. 2009 Jul 1;69(13):5321-30.
Title:	Smad2 and Smad3 phosphorylated at both linker and COOH-terminal regions transmit malignant TGF-beta signal in later stages of human colorectal cancer.
Author:	Matsuzaki, Koichi\|Kitano, Chiaki\|Murata, Miki\|Sekimoto, Go\|Yoshida, Katsunori\|Uemura, Yoshiko\|Seki, Toshihito\|Taketani, Shigeru\|Fujisawa, Jun-ichi\|Okazaki, Kazuichi
PMID:	19531654

35.
Journal:	Cancer Sci. 2009 Nov;100(11):2133-42.
Title:	Promoter-wide analysis of Smad4 binding sites in human epithelial cells.
Author:	Koinuma, Daizo\|Tsutsumi, Shuichi\|Kamimura, Naoko\|Imamura, Takeshi\|Aburatani, Hiroyuki\|Miyazono, Kohei
PMID:	19686287

36.
Journal:	PLoS One. 2010 Jan 20;5(1):e8789.
Title:	Functional exploration of the adult ovarian granulosa cell tumor-associated somatic FOXL2 mutation p.Cys134Trp (c.402C>G).
Author:	Benayoun, Berenice A\|Caburet, Sandrine\|Dipietromaria, Aurelie\|Georges, Adrien\|D'Haene, Barbara\|Pandaranayaka, P J Eswari\|L'Hote, David\|Todeschini, Anne-Laure\|Krishnaswamy, Sankaran\|Fellous, Marc\|De Baere, Elfride\|Veitia, Reiner A
PMID:	20098707

37.
Journal:	Mol Cancer Res. 2010 Dec;8(12):1579-90.
Title:	FMNL2 enhances invasion of colorectal carcinoma by inducing epithelial-mesenchymal transition.
Author:	Li, Yufa\|Zhu, Xiling\|Zeng, Yuanfeng\|Wang, Jianmei\|Zhang, Xiaojing\|Ding, Yan-qing\|Liang, Li
PMID:	21071512

38.
Journal:	Cancer Res. 2010 Oct 15;70(20):7960-9.
Title:	Dietary fish oil alters T lymphocyte cell populations and exacerbates disease in a mouse model of inflammatory colitis.
Author:	Woodworth, Hillary L\|McCaskey, Sarah J\|Duriancik, David M\|Clinthorne, Jonathan F\|Langohr, Ingeborg M\|Gardner, Elizabeth M\|Fenton, Jenifer I
PMID:	20798218

39.
Journal:	Int J Biochem Cell Biol. 2010 Dec;42(12):1964-72.
Title:	Activin A induces SLC5A8 expression through the Smad3 signaling pathway in human colon cancer RKO cells.
Author:	Zhang, Yu\|Bao, Yong-Li\|Yang, Mei-Ting\|Wu, Yin\|Yu, Chun-Lei\|Huang, Yan-Xin\|Sun, Ying\|Zheng, Li-Hua\|Li, Yu-Xin
PMID:	20732443

40.
Journal:	J Clin Invest. 2010 Mar;120(3):840-9.
Title:	Loss of Rab25 promotes the development of intestinal neoplasia in mice and is associated with human colorectal adenocarcinomas.
Author:	Nam, Ki Taek\|Lee, Hyuk-Joon\|Smith, J Joshua\|Lapierre, Lynne A\|Kamath, Vidya P\|Chen, Xi\|Aronow, Bruce J\|Yeatman, Timothy J\|Bhartur, Sheela G\|Calhoun, Benjamin C\|Condie, Brian\|Manley, Nancy R\|Beauchamp, R Daniel\|Coffey, Robert J\|Goldenring, James R
PMID:	20197623

41.
Journal:	Anat Rec (Hoboken). 2010 Jan;293(1):42-7.
Title:	Transforming growth factor-beta suppressed Id-1 Expression in a smad3-dependent manner in LoVo cells.
Author:	Song, Hongjiang\|Guo, Baoliang\|Zhang, Jianguo\|Song, Chunfang
PMID:	19798702

42.
Journal:	Cancer Lett. 2010 Jan 1;287(1):82-90.
Title:	5-Aminosalicylic acid inhibits TGF-beta1 signalling in colorectal cancer cells.
Author:	Koelink, Pim J\|Hawinkels, Lukas J A C\|Wiercinska, Eliza\|Sier, Cornelis F M\|ten Dijke, Peter\|Lamers, Cornelis B H W\|Hommes, Daan W\|Verspaget, Hein W
PMID:	19541409

43.
Journal:	Mol Carcinog. 2011 Jan;50(1):8-15.
Title:	Expression analysis of proline rich 15 (Prr15) in mouse and human gastrointestinal tumors.
Author:	Meunier, Dominique\|Patra, Kalicharan\|Smits, Ron\|Hagebarth, Andrea\|Luttges, Angela\|Jaussi, Rolf\|Wieduwilt, Matthew J\|Quintanilla-Fend, Leticia\|Himmelbauer, Heinz\|Fodde, Riccardo\|Fundele, Reinald H
PMID:	21061267

44.
Journal:	Cancer Epidemiol Biomarkers Prev. 2011 Jan;20(1):57-69.
Title:	Genetic variation in the TGF-beta signaling pathway and colon and rectal cancer risk.
Author:	Slattery, Martha L\|Herrick, Jennifer S\|Lundgreen, Abbie\|Wolff, Roger K
PMID:	21068203

45.
Journal:	Cancer. 2011 Sep 15;117(18):4175-83.
Title:	Genetic variation in the transforming growth factor-beta signaling pathway and survival after diagnosis with colon and rectal cancer.
Author:	Slattery, Martha L\|Lundgreen, Abbie\|Herrick, Jennifer S\|Wolff, Roger K\|Caan, Bette J
PMID:	21365634

46.
Journal:	Am J Physiol Gastrointest Liver Physiol. 2011 Jul;301(1):G156-64.
Title:	Dietary fiber enhances TGF-beta signaling and growth inhibition in the gut.
Author:	Cao, Yanna\|Gao, Xuxia\|Zhang, Weili\|Zhang, Guohua\|Nguyen, Anthony K\|Liu, Xianghua\|Jimenez, Fernando\|Cox, Charles S Jr\|Townsend, Courtney M Jr\|Ko, Tien C
PMID:	21454444

47.
Journal:	Comp Med. 2011 Jun;61(3):219-26.
Title:	Lack of effect of murine norovirus infection on a mouse model of bacteria-induced colon cancer.
Author:	Lencioni, Karen C\|Drivdahl, Rolf\|Seamons, Audrey\|Treuting, Piper M\|Brabb, Thea\|Maggio-Price, Lillian
PMID:	21819691

48.
Journal:	BMC Cancer. 2012 Aug 1;12:331.
Title:	A systems biology approach to the global analysis of transcription factors in colorectal cancer.
Author:	Pradhan, Meeta P\|Prasad, Nagendra K A\|Palakal, Mathew J
PMID:	22852817

49.
Journal:	Oncol Rep. 2012 Jul;28(1):179-85.
Title:	Lentivirus-mediated RNA interference targeting WWTR1 in human colorectal cancer cells inhibits cell proliferation in vitro and tumor growth in vivo.
Author:	Pan, Jie\|Li, Shaotang\|Chi, Pan\|Xu, Zongbin\|Lu, Xingrong\|Huang, Ying
PMID:	22470139

50.
Journal:	Lab Invest. 2012 Jun;92(6):883-95.
Title:	Gastric tumor development in Smad3-deficient mice initiates from forestomach/glandular transition zone along the lesser curvature.
Author:	Nam, Ki Taek\|O'Neal, Ryan\|Lee, Yeo Song\|Lee, Yong Chan\|Coffey, Robert J\|Goldenring, James R
PMID:	22411066

51.
Journal:	Cancer Res. 2013 Jan 15;73(2):725-35.
Title:	SMAD2, SMAD3 and SMAD4 mutations in colorectal cancer.
Author:	Fleming, Nicholas I\|Jorissen, Robert N\|Mouradov, Dmitri\|Christie, Michael\|Sakthianandeswaren, Anuratha\|Palmieri, Michelle\|Day, Fiona\|Li, Shan\|Tsui, Cary\|Lipton, Lara\|Desai, Jayesh\|Jones, Ian T\|McLaughlin, Stephen\|Ward, Robyn L\|Hawkins, Nicholas J\|Ruszkiew
PMID:	23139211

52.
Journal:	PLoS One. 2013 Nov 11;8(11):e79182.
Title:	Characterization of dextran sodium sulfate-induced inflammation and colonic tumorigenesis in Smad3(-/-) mice with dysregulated TGFbeta.
Author:	Seamons, Audrey\|Treuting, Piper M\|Brabb, Thea\|Maggio-Price, Lillian
PMID:	24244446

53.
Journal:	Cancer Res. 2013 Nov 15;73(22):6654-66.
Title:	Intestinal GUCY2C prevents TGF-beta secretion coordinating desmoplasia and hyperproliferation in colorectal cancer.
Author:	Gibbons, Ahmara V\|Lin, Jieru E\|Kim, Gilbert W\|Marszalowicz, Glen P\|Li, Peng\|Stoecker, Brian A\|Blomain, Erik S\|Rattan, Satish\|Snook, Adam E\|Schulz, Stephanie\|Waldman, Scott A
PMID:	24085786

54.
Journal:	Int J Mol Sci. 2013 Jan 31;14(2):2980-95.
Title:	Compound K, a Ginsenoside Metabolite, Inhibits Colon Cancer Growth via Multiple Pathways Including p53-p21 Interactions.
Author:	Zhang, Zhiyu\|Du, Guang-Jian\|Wang, Chong-Zhi\|Wen, Xiao-Dong\|Calway, Tyler\|Li, Zejuan\|He, Tong-Chuan\|Du, Wei\|Bissonnette, Marc\|Musch, Mark W\|Chang, Eugene B\|Yuan, Chun-Su
PMID:	23434653

55.
Journal:	Exp Cell Res. 2013 Feb 1;319(3):12-22.
Title:	Epithelial to mesenchymal transition and cancer stem cell phenotypes leading to liver metastasis are abrogated by the novel TGFbeta1-targeting peptides P17 and P144.
Author:	Zubeldia, Idoia G\|Bleau, Anne-Marie\|Redrado, Miriam\|Serrano, Diego\|Agliano, Alice\|Gil-Puig, Carmen\|Vidal-Vanaclocha, Fernando\|Lecanda, Jon\|Calvo, Alfonso
PMID:	23153552

56.
Journal:	PLoS One. 2013;8(3):e59918.
Title:	TGF-Beta suppresses VEGFA-mediated angiogenesis in colon cancer metastasis.
Author:	Geng, Liying\|Chaudhuri, Anathbandhu\|Talmon, Geoffrey\|Wisecarver, James L\|Wang, Jing
PMID:	23536895

57.
Journal:	Biomed Res Int. 2014;2014:364134.
Title:	Nodal promotes the self-renewal of human colon cancer stem cells via an autocrine manner through Smad2/3 signaling pathway.
Author:	Gong, Yuehua\|Guo, Ying\|Hai, Yanan\|Yang, Hao\|Liu, Yang\|Yang, Shi\|Zhang, Zhenzhen\|Ma, Meng\|Liu, Linhong\|Li, Zheng\|He, Zuping
PMID:	24696849

58.
Journal:	J Clin Invest. 2014 Jun;124(6):2472-82.
Title:	Synthetic triterpenoid induces 15-PGDH expression and suppresses inflammation-driven colon carcinogenesis.
Author:	Choi, Sung Hee\|Kim, Byung-Gyu\|Robinson, Janet\|Fink, Steve\|Yan, Min\|Sporn, Michael B\|Markowitz, Sanford D\|Letterio, John J
PMID:	24837432

59.
Journal:	Cancer Res. 2014 Aug 15;74(16):4398-408.
Title:	Increased dietary vitamin D suppresses MAPK signaling, colitis, and colon cancer.
Author:	Meeker, Stacey\|Seamons, Audrey\|Paik, Jisun\|Treuting, Piper M\|Brabb, Thea\|Grady, William M\|Maggio-Price, Lillian
PMID:	24938764

60.
Journal:	J Gastrointestin Liver Dis. 2014 Dec;23(4):413-8.
Title:	TIMP-1 expression in human colorectal cancer is associated with SMAD3 gene expression levels: a pilot study.
Author:	Ionescu, Calin\|Braicu, Cornelia\|Chiorean, Roxana\|Cojocneanu Petric, Roxana\|Neagoe, Emilian\|Pop, Laura\|Chira, Sergiu\|Berindan-Neagoe, Ioana
PMID:	25532000

61.
Journal:	PLoS One. 2014 Dec 26;9(12):e116169.
Title:	The influence of the CHIEF pathway on colorectal cancer-specific mortality.
Author:	Slattery, Martha L\|Lundgreen, Abbie
PMID:	25541970

62.
Journal:	Zhonghua Zhong Liu Za Zhi. 2014 Oct;36(10):739-45.
Title:	[microRNA-140 suppresses the migration and invasion of colorectal cancer cells through targeting Smad3].
Author:	Zhao, Wenyue\|Zou, Jiarui\|Wang, Bo\|Fan, Panhong\|Mao, Jun\|Li, Jiazhi\|Liu, Han\|Xiao, Jing\|Ma, Wei\|Wang, Mei\|Li, Lianhong\|Song, Bo
PMID:	25567303

63.
Journal:	World J Surg. 2015 May;39(5):1257-67.
Title:	Relationships between SMAD3 expression and preoperative fluoropyrimidine-based chemoradiotherapy response in locally advanced rectal cancer patients.
Author:	Huang, Ming-Yii\|Lin, Chih-Hung\|Huang, Chun-Ming\|Tsai, Hsiang-Lin\|Huang, Ching-Wen\|Yeh, Yung-Sung\|Chai, Chee-Yin\|Wang, Jaw-Yuan
PMID:	25561186

64.
Journal:	Oncotarget. 2015 Nov 10;6(35):37600-12.
Title:	Revealing potential molecular targets bridging colitis and colorectal cancer based on multidimensional integration strategy.
Author:	Guan, Xu\|Yi, Ying\|Huang, Yan\|Hu, Yongfei\|Li, Xiaobo\|Wang, Xishan\|Fan, Huihui\|Wang, Guiyu\|Wang, Dong
PMID:	26461477

65.
Journal:	Gastroenterol Hepatol Bed Bench. 2015 Summer;8(3):215-24.
Title:	Protein-Protein Interaction Network could reveal the relationship between the breast and colon cancer.
Author:	Zamanian-Azodi, Mona\|Rezaei-Tavirani, Mostafa\|Rahmati-Rad, Sara\|Hasanzadeh, Hadi\|Rezaei Tavirani, Majid\|Seyyedi, Samaneh Sadat
PMID:	26328044

66.
Journal:	J Cell Physiol. 2015 Dec;230(12):3105-14.
Title:	The Effects of miR-20a on p21: Two Mechanisms Blocking Growth Arrest in TGF-beta-Responsive Colon Carcinoma.
Author:	Sokolova, Viktorija\|Fiorino, Antonio\|Zoni, Eugenio\|Crippa, Elisabetta\|Reid, James F\|Gariboldi, Manuela\|Pierotti, Marco A
PMID:	26012475

67.
Journal:	PLoS One. 2015 May 14;10(5):e0126670.
Title:	Co-evolution of somatic variation in primary and metastatic colorectal cancer may expand biopsy indications in the molecular era.
Author:	Kim, Richard\|Schell, Michael J\|Teer, Jamie K\|Greenawalt, Danielle M\|Yang, Mingli\|Yeatman, Timothy J
PMID:	25974029

68.
Journal:	Oncol Rep. 2015 Jan;33(1):185-92.
Title:	Effect of Smad3/4 on chemotherapeutic drug sensitivity in colorectal cancer cells.
Author:	Moon, Sung Ung\|Kang, Mi Hyun\|Sung, Ji Hea\|Kim, Jin Won\|Lee, Jeong Ok\|Kim, Yu Jung\|Lee, Keun Wook\|Bang, Soo Mee\|Lee, Jong Seok\|Kim, Jee Hyun
PMID:	25370208

69.
Journal:	Transl Oncol. 2016 Dec;9(6):512-520.
Title:	SDHB deficiency promotes TGFbeta-mediated invasion and metastasis of colorectal cancer through transcriptional repression complex SNAIL1-SMAD3/4.
Author:	Wang, Haiyu\|Chen, Yusheng\|Wu, Guohao
PMID:	27816688

70.
Journal:	Oncotarget. 2016 Nov 15;7(46):76224-76237.
Title:	Focal adhesion molecule Kindlin-1 mediates activation of TGF-beta signaling by interacting with TGF-betaRI, SARA and Smad3 in colorectal cancer cells.
Author:	Kong, Jinfeng\|Du, Juan\|Wang, Yunling\|Yang, Mingzi\|Gao, Jianchao\|Wei, Xiaofan\|Fang, Weigang\|Zhan, Jun\|Zhang, Hongquan
PMID:	27776350

71.
Journal:	Oncol Lett. 2016 Oct;12(4):2329-2336.
Title:	Mechanism analysis of colorectal cancer according to the microRNA expression profile.
Author:	Li, Hong\|Zhang, Huichao\|Lu, Gang\|Li, Qingjing\|Gu, Jifeng\|Song, Yuan\|Gao, Shejun\|Ding, Yawen
PMID:	27698796

72.
Journal:	Oncotarget. 2016 Oct 11;7(41):67196-67211.
Title:	TGF-beta1 promotes colorectal cancer immune escape by elevating B7-H3 and B7-H4 via the miR-155/miR-143 axis.
Author:	Zhou, Xinru\|Mao, Yong\|Zhu, Jianjie\|Meng, Fanyi\|Chen, Qi\|Tao, Lihua\|Li, Rui\|Fu, Fengqing\|Liu, Cuiping\|Hu, Yuanjia\|Wang, Weipeng\|Zhang, Hongjian\|Hua, Dong\|Chen, Weichang\|Zhang, Xueguang
PMID:	27626488

73.
Journal:	Int Immunopharmacol. 2016 Jun;35:287-293.
Title:	Tolfenamic acid downregulates beta-catenin in colon cancer.
Author:	Ha, Taekyu\|Lou, Zhiyuan\|Baek, Seung Joon\|Lee, Seong-Ho
PMID:	27089389

74.
Journal:	Oncotarget. 2016 Apr 19;7(16):22077-91.
Title:	The TGF-beta pathway is activated by 5-fluorouracil treatment in drug resistant colorectal carcinoma cells.
Author:	Romano, Gabriele\|Santi, Ludovica\|Bianco, Maria Rosaria\|Giuffre, Maria Rita\|Pettinato, Mariateresa\|Bugarin, Cristina\|Garanzini, Cristina\|Savarese, Leonilde\|Leoni, Silvia\|Cerrito, Maria Grazia\|Leone, Biagio Eugenio\|Gaipa, Giuseppe\|Grassilli, Emanuela\|Papa,
PMID:	26956045

75.
Journal:	Oncotarget. 2016 Apr 12;7(15):19781-93.
Title:	Predictive role of microRNA-related genetic polymorphisms in the pathological complete response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer patients.
Author:	Dreussi, Eva\|Pucciarelli, Salvatore\|De Paoli, Antonino\|Polesel, Jerry\|Canzonieri, Vincenzo\|Agostini, Marco\|Friso, Maria Luisa\|Belluco, Claudio\|Buonadonna, Angela\|Lonardi, Sara\|Zanusso, Chiara\|De Mattia, Elena\|Toffoli, Giuseppe\|Cecchin, Erika
PMID:	26934318

76.
Journal:	Sci Rep. 2016 Feb 9;6:20739.
Title:	Lithium inhibits tumor lymphangiogenesis and metastasis through the inhibition of TGFBIp expression in cancer cells.
Author:	Maeng, Yong-Sun\|Lee, Rina\|Lee, Boram\|Choi, Seung-Il\|Kim, Eung Kweon
PMID:	26857144

77.
Journal:	Phys Med Biol. 2016 Feb 7;61(3):N60-9.
Title:	Imaging colon cancer development in mice: IL-6 deficiency prevents adenoma in azoxymethane-treated Smad3 knockouts.
Author:	Harpel, Kaitlin\|Leung, Sarah\|Rice, Photini Faith\|Jones, Mykella\|Barton, Jennifer K\|Bommireddy, Ramireddy
PMID:	26758693

78.
Journal:	Cell Microbiol. 2016 May;18(5):733-47.
Title:	Rotavirus-induced miR-142-5p elicits proviral milieu by targeting non-canonical transforming growth factor beta signalling and apoptosis in cells.
Author:	Chanda, Shampa\|Nandi, Satabdi\|Chawla-Sarkar, Mamta
PMID:	26572508

79.
Journal:	Oncotarget. 2016 Jan 5;7(1):860-72.
Title:	GDF15 promotes EMT and metastasis in colorectal cancer.
Author:	Li, Chen\|Wang, Jingyu\|Kong, Jianlu\|Tang, Jinlong\|Wu, Yihua\|Xu, Enping\|Zhang, Honghe\|Lai, Maode
PMID:	26497212

80.
Journal:	Sci Rep. 2016 Apr 18;6:24671.
Title:	Establishment and characterization of HROC69 - a Crohn s related colonic carcinoma cell line and its matched patient-derived xenograft.
Author:	Kuehn, Florian\|Mullins, Christina S\|Krohn, Mathias\|Harnack, Christine\|Ramer, Robert\|Kramer, Oliver H\|Klar, Ernst\|Huehns, Maja\|Linnebacher, Michael
PMID:	27087592

81.
Journal:	Oncol Lett. 2017 Apr;13(4):2557-2562.
Title:	Deregulation of miR-193b affects the growth of colon cancer cells via transforming growth factor-beta and regulation of the SMAD3 pathway.
Author:	Wu, Kaiming\|Zhao, Zhenxian\|Ma, Jun\|Chen, Jianhui\|Peng, Jianjun\|Yang, Shibin\|He, Yulong
PMID:	28454433

82.
Journal:	J BUON. 2017 Nov-Dec;22(6):1457-1462.
Title:	X-ray-induced epithelial-mesenchymal transition in SW480 colorectal cancer cells and its potential mechanisms.
Author:	Lin, Suyong\|Chen, Shaoqin\|Chen, Zhihua\|Dai, Qibao\|Ke, Chunlin
PMID:	29332338

83.
Journal:	mSystems. 2017 Sep 26;2(5). pii: mSystems00065-17.
Title:	Functional Changes in the Gut Microbiome Contribute to Transforming Growth Factor beta-Deficient Colon Cancer.
Author:	Daniel, Scott G\|Ball, Corbie L\|Besselsen, David G\|Doetschman, Tom\|Hurwitz, Bonnie L
PMID:	28951889

84.
Journal:	Am J Physiol Renal Physiol. 2017 Dec 1;313(6):F1223-F1231.
Title:	Aberrant Smad3 phosphoisoforms in cyst-lining epithelial cells in the cpk mouse, a model of autosomal recessive polycystic kidney disease.
Author:	Hama, Taketsugu\|Nakanishi, Koichi\|Sato, Masashi\|Mukaiyama, Hironobu\|Togawa, Hiroko\|Shima, Yuko\|Miyajima, Masayasu\|Nozu, Kandai\|Nagao, Shizuko\|Takahashi, Hisahide\|Sako, Mayumi\|Iijima, Kazumoto\|Yoshikawa, Norishige\|Suzuki, Hiroyuki
PMID:	28877884

85.
Journal:	Hum Pathol. 2017 Aug;66:34-39.
Title:	Significance of positive and inhibitory regulators in the TGF-beta signaling pathway in colorectal cancers.
Author:	Coates, Ryan F\|Gardner, Juli-Anne\|Gao, Yuan\|Cortright, Valerie M\|Mitchell, Jeannette M\|Ashikaga, Takamaru\|Skelly, Joan\|Yang, Michelle X
PMID:	28601657

86.
Journal:	Cell Death Dis. 2017 May 4;8(5):e2761.
Title:	MiR-1 suppresses tumor cell proliferation in colorectal cancer by inhibition of Smad3-mediated tumor glycolysis.
Author:	Xu, Wanfu\|Zhang, Zijing\|Zou, Kejian\|Cheng, Yang\|Yang, Min\|Chen, Huan\|Wang, Hongli\|Zhao, Junhong\|Chen, Peiyu\|He, Liying\|Chen, Xinwen\|Geng, Lanlan\|Gong, Sitang
PMID:	28471448

87.
Journal:	Oncol Lett. 2017 Mar;13(3):1535-1538.
Title:	Smad3 mutant mice develop colon cancer with overexpression of COX-2.
Author:	Zhu, Yu-Ping\|Liu, Zhuo\|Fu, Zhi-Xuan\|Li, De-Chuan
PMID:	28454287

88.
Journal:	Anat Rec (Hoboken). 2017 Sep;300(9):1560-1569.
Title:	Smad4 Inhibits VEGF-A and VEGF-C Expressions via Enhancing Smad3 Phosphorylation in Colon Cancer.
Author:	Li, Xuemei\|Li, Xinlei\|Lv, Xiaohong\|Xiao, Jianbing\|Liu, Baoquan\|Zhang, Yafang
PMID:	28445620

89.
Journal:	PLoS One. 2017 Apr 17;12(4):e0176096.
Title:	TGFbeta/Smad3 regulates proliferation and apoptosis through IRS-1 inhibition in colon cancer cells.
Author:	Bailey, Katie L\|Agarwal, Ekta\|Chowdhury, Sanjib\|Luo, Jiangtao\|Brattain, Michael G\|Black, Jennifer D\|Wang, Jing
PMID:	28414818

90.
Journal:	Oncotarget. 2017 Mar 7;8(10):16765-16783.
Title:	Genetic variants in the TGFbeta-signaling pathway influence expression of miRNAs in colon and rectal normal mucosa and tumor tissue.
Author:	Slattery, Martha L\|Trivellas, Andromahi\|Pellatt, Andrew J\|Mullany, Lila E\|Stevens, John R\|Wolff, Roger K\|Herrick, Jennifer S
PMID:	28061442

91.
Journal:	Oncol Rep. 2017 Jan;37(1):115-122.
Title:	TGF-beta1 induces PGP9.5 expression in CAFs to promote the growth of colorectal cancer cells.
Author:	Wen, Wei\|Liu, Ge\|Jin, Ke\|Hu, Xiang
PMID:	27840994

92.
Journal:	Cell Death Dis. 2018 Feb 15;9(3):263.
Title:	NIT1 suppresses tumour proliferation by activating the TGFbeta1-Smad2/3 signalling pathway in colorectal cancer.
Author:	Lin, Chun\|Zhang, Jianming\|Lu, Yanxia\|Li, Xiaomin\|Zhang, Wenjuan\|Zhang, Wei\|Lin, Weihao\|Zheng, Lin\|Li, Xuenong
PMID:	29449642

93.
Journal:	Mol Ther Nucleic Acids. 2018 Mar 2;10:426-437.
Title:	MicroRNA-140 Inhibits the Epithelial-Mesenchymal Transition and Metastasis in Colorectal Cancer.
Author:	Li, Jiazhi\|Zou, Kun\|Yu, Lihui\|Zhao, Wenyue\|Lu, Ying\|Mao, Jun\|Wang, Bo\|Wang, Lu\|Fan, Shujun\|Song, Bo\|Li, Lianhong
PMID:	29499953

94.
Journal:	J Biol Chem. 2018 May 25;293(21):8242-8254.
Title:	TGFbeta and IGF1R signaling activates protein kinase A through differential regulation of ezrin phosphorylation in colon cancer cells.
Author:	Leiphrakpam, Premila D\|Brattain, Michael G\|Black, Jennifer D\|Wang, Jing
PMID:	29599290

95.
Journal:	Cell Death Dis. 2018 May 29;9(6):654.
Title:	FSTL1 interacts with VIM and promotes colorectal cancer metastasis via activating the focal adhesion signalling pathway.
Author:	Gu, Chuansha\|Wang, Xiaoyan\|Long, Ting\|Wang, Xia\|Zhong, Yan\|Ma, Yidan\|Hu, Zhiyan\|Li, Zuguo
PMID:	29844309

96.
Journal:	Clin Cancer Res. 2018 Jul 2. pii: 1078-0432.CCR-18-0630.
Title:	Dynamics of Genome Alterations in Crohn's Disease-Associated Colorectal Carcinogenesis.
Author:	Hirsch, Daniela\|Wangsa, Darawalee\|Zhu, Yuelin J\|Hu, Yue\|Edelman, Daniel C\|Meltzer, Paul S\|Heselmeyer-Haddad, Kerstin\|Ott, Claudia\|Kienle, Peter\|Galata, Christian\|Horisberger, Karoline\|Ried, Thomas\|Gaiser, Timo
PMID:	29967250

97.
Journal:	J Cell Biochem. 2018 Oct 10.
Title:	TrkC-miR2 regulates TGFbeta signaling pathway through targeting of SMAD3 transcript.
Author:	Dokanehiifard, Sadat\|Soltani, Bahram M
PMID:	30304551