Primary Site >> Colorectal Cancer
Gene >> SMAD3
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Ref: Genomic structure of the human Smad3 gene and its infrequent alterations in colorectal cancers. PMID: 9464505 Ref: Smad3 mutant mice develop metastatic colorectal cancer. PMID: 9753318 |
Ref: Higher frequency of Smad4 gene mutation in human colorectal cancer with distant metastasis. PMID: 10340381 Ref: Expression of Smad proteins in human colorectal cancer. PMID: 10389752 Ref: Screening SMAD1, SMAD2, SMAD3, and SMAD5 for germline mutations in juvenile polyposis syndrome. PMID: 10446110 Ref: Smad4/DPC4 silencing and hyperactive Ras jointly disrupt transforming growth factor-beta antiproliferative responses in colon cancer cells. PMID: 10559252 |
Ref: Aberrant transforming growth factor-beta signaling in azoxymethane-induced mouse colon tumors. PMID: 11536370 |
Ref: Pathway-specific tumor suppression. Reduction of p27 accelerates gastrointestinal tumorigenesis in Apc mutant mice, but not in Smad3 mutant mice. PMID: 12086850 Ref: The androgen receptor CAG repeat: a modifier of carcinogenesis? PMID: 12161010 |
Ref: Converging signals synergistically activate the LAMC2 promoter and lead to accumulation of the laminin gamma 2 chain in human colon carcinoma cells. PMID: 12519076 Ref: TGF-beta-induced nuclear localization of Smad2 and Smad3 in Smad4 null cancer cell lines. PMID: 12618756 Ref: Mutational analysis of TGF-beta type II receptor, Smad2, Smad3, Smad4, Smad6 and Smad7 genes in colorectal cancer. PMID: 12866583 |
Ref: Molecular and functional consequences of Smad4 C-terminal missense mutations in colorectal tumour cells. PMID: 14715079 Ref: Transforming growth factor-beta signaling is differentially inhibited by Smad2D450E and Smad3D407E. PMID: 14720321 |
Ref: Acceleration of Smad2 and Smad3 phosphorylation via c-Jun NH(2)-terminal kinase during human colorectal carcinogenesis. PMID: 15665291 Ref: TGF-beta signaling in colon cancer cells. PMID: 15711891 Ref: Inhibitory effect of genistein on mouse colon cancer MC-26 cells involved TGF-beta1/Smad pathway. PMID: 15963949 Ref: Smad4 dependency defines two classes of transforming growth factor {beta} (TGF-{beta}) target genes and distinguishes TGF-{beta}-induced epithelial-mesenchymal transition from its antiproliferative and migratory responses. PMID: 16135802 |
Ref: Helicobacter infection is required for inflammation and colon cancer in SMAD3-deficient mice. PMID: 16424015 Ref: Evi1 is a survival factor which conveys resistance to both TGFbeta- and taxol-mediated cell death via PI3K/AKT. PMID: 16462766 Ref: Smad3 phosphoisoform-mediated signaling during sporadic human colorectal carcinogenesis. PMID: 16528675 Ref: Dietary fiber enhances a tumor suppressor signaling pathway in the gut. PMID: 16632996 Ref: Smad3 deficiency promotes tumorigenesis in the distal colon of ApcMin/+ mice. PMID: 16951153 Ref: TGF-beta during human colorectal carcinogenesis: the shift from epithelial to mesenchymal signaling. PMID: 17093904 |
Ref: Genetic alterations of the TGF-beta signaling pathway in colorectal cancer cell lines: a novel mutation in Smad3 associated with the inactivation of TGF-beta-induced transcriptional activation. PMID: 16828225 Ref: Cell surface fucosylation does not affect development of colon tumors in mice with germline Smad3 mutation. PMID: 17264540 Ref: Targeted imaging of colonic tumors in smad3-/- mice discriminates cancer and inflammation. PMID: 17426249 Ref: Dietary modulation of colon cancer risk. PMID: 17951506 |
Ref: Involvement of Smad3 phosphoisoform-mediated signaling in the development of colonic cancer in IL-10-deficient mice. PMID: 18497983 Ref: TGFbeta modulates PTEN expression independently of SMAD signaling for growth proliferation in colon cancer cells. PMID: 18769113 |
Ref: Bacterial infection of Smad3/Rag2 double-null mice with transforming growth factor-beta dysregulation as a model for studying inflammation-associated colon cancer. PMID: 19119184 Ref: Tgfbr1 haploinsufficiency is a potent modifier of colorectal cancer development. PMID: 19147584 Ref: The F-box protein beta-TrCp1/Fbw1a interacts with p300 to enhance beta-catenin transcriptional activity. PMID: 19297328 Ref: Smad2 and Smad3 phosphorylated at both linker and COOH-terminal regions transmit malignant TGF-beta signal in later stages of human colorectal cancer. PMID: 19531654 Ref: Promoter-wide analysis of Smad4 binding sites in human epithelial cells. PMID: 19686287 |
Ref: 5-Aminosalicylic acid inhibits TGF-beta1 signalling in colorectal cancer cells. PMID: 19541409 Ref: Transforming growth factor-beta suppressed Id-1 Expression in a smad3-dependent manner in LoVo cells. PMID: 19798702 Ref: Functional exploration of the adult ovarian granulosa cell tumor-associated somatic FOXL2 mutation p.Cys134Trp (c.402C>G). PMID: 20098707 Ref: Loss of Rab25 promotes the development of intestinal neoplasia in mice and is associated with human colorectal adenocarcinomas. PMID: 20197623 Ref: Activin A induces SLC5A8 expression through the Smad3 signaling pathway in human colon cancer RKO cells. PMID: 20732443 Ref: Dietary fish oil alters T lymphocyte cell populations and exacerbates disease in a mouse model of inflammatory colitis. PMID: 20798218 Ref: FMNL2 enhances invasion of colorectal carcinoma by inducing epithelial-mesenchymal transition. PMID: 21071512 |
Ref: Expression analysis of proline rich 15 (Prr15) in mouse and human gastrointestinal tumors. PMID: 21061267 Ref: Genetic variation in the TGF-beta signaling pathway and colon and rectal cancer risk. PMID: 21068203 Ref: Genetic variation in the transforming growth factor-beta signaling pathway and survival after diagnosis with colon and rectal cancer. PMID: 21365634 Ref: Dietary fiber enhances TGF-beta signaling and growth inhibition in the gut. PMID: 21454444 Ref: Lack of effect of murine norovirus infection on a mouse model of bacteria-induced colon cancer. PMID: 21819691 |
Ref: Gastric tumor development in Smad3-deficient mice initiates from forestomach/glandular transition zone along the lesser curvature. PMID: 22411066 Ref: Lentivirus-mediated RNA interference targeting WWTR1 in human colorectal cancer cells inhibits cell proliferation in vitro and tumor growth in vivo. PMID: 22470139 Ref: A systems biology approach to the global analysis of transcription factors in colorectal cancer. PMID: 22852817 |
Ref: SMAD2, SMAD3 and SMAD4 mutations in colorectal cancer. PMID: 23139211 Ref: Epithelial to mesenchymal transition and cancer stem cell phenotypes leading to liver metastasis are abrogated by the novel TGFbeta1-targeting peptides P17 and P144. PMID: 23153552 Ref: Compound K, a Ginsenoside Metabolite, Inhibits Colon Cancer Growth via Multiple Pathways Including p53-p21 Interactions. PMID: 23434653 Ref: TGF-Beta suppresses VEGFA-mediated angiogenesis in colon cancer metastasis. PMID: 23536895 Ref: Intestinal GUCY2C prevents TGF-beta secretion coordinating desmoplasia and hyperproliferation in colorectal cancer. PMID: 24085786 Ref: Characterization of dextran sodium sulfate-induced inflammation and colonic tumorigenesis in Smad3(-/-) mice with dysregulated TGFbeta. PMID: 24244446 |
Ref: Nodal promotes the self-renewal of human colon cancer stem cells via an autocrine manner through Smad2/3 signaling pathway. PMID: 24696849 Ref: Synthetic triterpenoid induces 15-PGDH expression and suppresses inflammation-driven colon carcinogenesis. PMID: 24837432 Ref: Increased dietary vitamin D suppresses MAPK signaling, colitis, and colon cancer. PMID: 24938764 Ref: TIMP-1 expression in human colorectal cancer is associated with SMAD3 gene expression levels: a pilot study. PMID: 25532000 Ref: The influence of the CHIEF pathway on colorectal cancer-specific mortality. PMID: 25541970 Ref: [microRNA-140 suppresses the migration and invasion of colorectal cancer cells through targeting Smad3]. PMID: 25567303 |
Ref: Effect of Smad3/4 on chemotherapeutic drug sensitivity in colorectal cancer cells. PMID: 25370208 Ref: Relationships between SMAD3 expression and preoperative fluoropyrimidine-based chemoradiotherapy response in locally advanced rectal cancer patients. PMID: 25561186 Ref: Co-evolution of somatic variation in primary and metastatic colorectal cancer may expand biopsy indications in the molecular era. PMID: 25974029 Ref: The Effects of miR-20a on p21: Two Mechanisms Blocking Growth Arrest in TGF-beta-Responsive Colon Carcinoma. PMID: 26012475 Ref: Protein-Protein Interaction Network could reveal the relationship between the breast and colon cancer. PMID: 26328044 Ref: Revealing potential molecular targets bridging colitis and colorectal cancer based on multidimensional integration strategy. PMID: 26461477 |
Ref: GDF15 promotes EMT and metastasis in colorectal cancer. PMID: 26497212 Ref: Rotavirus-induced miR-142-5p elicits proviral milieu by targeting non-canonical transforming growth factor beta signalling and apoptosis in cells. PMID: 26572508 Ref: Imaging colon cancer development in mice: IL-6 deficiency prevents adenoma in azoxymethane-treated Smad3 knockouts. PMID: 26758693 Ref: Lithium inhibits tumor lymphangiogenesis and metastasis through the inhibition of TGFBIp expression in cancer cells. PMID: 26857144 Ref: Predictive role of microRNA-related genetic polymorphisms in the pathological complete response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer patients. PMID: 26934318 Ref: The TGF-beta pathway is activated by 5-fluorouracil treatment in drug resistant colorectal carcinoma cells. PMID: 26956045 Ref: Establishment and characterization of HROC69 - a Crohn s related colonic carcinoma cell line and its matched patient-derived xenograft. PMID: 27087592 Ref: Tolfenamic acid downregulates beta-catenin in colon cancer. PMID: 27089389 Ref: TGF-beta1 promotes colorectal cancer immune escape by elevating B7-H3 and B7-H4 via the miR-155/miR-143 axis. PMID: 27626488 Ref: Mechanism analysis of colorectal cancer according to the microRNA expression profile. PMID: 27698796 Ref: Focal adhesion molecule Kindlin-1 mediates activation of TGF-beta signaling by interacting with TGF-betaRI, SARA and Smad3 in colorectal cancer cells. PMID: 27776350 Ref: SDHB deficiency promotes TGFbeta-mediated invasion and metastasis of colorectal cancer through transcriptional repression complex SNAIL1-SMAD3/4. PMID: 27816688 |
Ref: TGF-beta1 induces PGP9.5 expression in CAFs to promote the growth of colorectal cancer cells. PMID: 27840994 Ref: Genetic variants in the TGFbeta-signaling pathway influence expression of miRNAs in colon and rectal normal mucosa and tumor tissue. PMID: 28061442 Ref: TGFbeta/Smad3 regulates proliferation and apoptosis through IRS-1 inhibition in colon cancer cells. PMID: 28414818 Ref: Smad4 Inhibits VEGF-A and VEGF-C Expressions via Enhancing Smad3 Phosphorylation in Colon Cancer. PMID: 28445620 Ref: Smad3 mutant mice develop colon cancer with overexpression of COX-2. PMID: 28454287 Ref: Deregulation of miR-193b affects the growth of colon cancer cells via transforming growth factor-beta and regulation of the SMAD3 pathway. PMID: 28454433 Ref: MiR-1 suppresses tumor cell proliferation in colorectal cancer by inhibition of Smad3-mediated tumor glycolysis. PMID: 28471448 Ref: Significance of positive and inhibitory regulators in the TGF-beta signaling pathway in colorectal cancers. PMID: 28601657 Ref: Aberrant Smad3 phosphoisoforms in cyst-lining epithelial cells in the cpk mouse, a model of autosomal recessive polycystic kidney disease. PMID: 28877884 Ref: Functional Changes in the Gut Microbiome Contribute to Transforming Growth Factor beta-Deficient Colon Cancer. PMID: 28951889 Ref: X-ray-induced epithelial-mesenchymal transition in SW480 colorectal cancer cells and its potential mechanisms. PMID: 29332338 |
Ref: NIT1 suppresses tumour proliferation by activating the TGFbeta1-Smad2/3 signalling pathway in colorectal cancer. PMID: 29449642 Ref: MicroRNA-140 Inhibits the Epithelial-Mesenchymal Transition and Metastasis in Colorectal Cancer. PMID: 29499953 Ref: TGFbeta and IGF1R signaling activates protein kinase A through differential regulation of ezrin phosphorylation in colon cancer cells. PMID: 29599290 Ref: FSTL1 interacts with VIM and promotes colorectal cancer metastasis via activating the focal adhesion signalling pathway. PMID: 29844309 Ref: Dynamics of Genome Alterations in Crohn's Disease-Associated Colorectal Carcinogenesis. PMID: 29967250 Ref: TrkC-miR2 regulates TGFbeta signaling pathway through targeting of SMAD3 transcript. PMID: 30304551 |