Primary Site >> Stomach Cancer

Gene >> SMAD2

Journal: Jpn J Clin Oncol. 1999 Jan;29(1):3-7.
Title: No mutations of the Smad2 gene in human sporadic gastric carcinomas.
Author: Shitara, Y|Yokozaki, H|Yasui, W|Takenoshita, S|Kuwano, H|Nagamachi, Y|Tahara, E
PMID: 10073143
Journal: Cytokine Growth Factor Rev. 2000 Mar-Jun;11(1-2):49-58.
Title: Functions of mammalian Smad genes as revealed by targeted gene disruption in mice.
Author: Weinstein, M|Yang, X|Deng, C
PMID: 10708952
Journal: Oncogene. 2003 Oct 30;22(49):7838-47.
Title: Interferon-gamma suppresses transforming growth factor-beta-induced invasion of gastric carcinoma cells through cross-talk of Smad pathway in a three-dimensional culture model.
Author: Kuga, Hirotaka|Morisaki, Takashi|Nakamura, Katsuya|Onishi, Hideya|Noshiro, Hirokazu|Uchiyama, Akihiko|Tanaka, Masao|Katano, Mitsuo
PMID: 14586410
Journal: Int J Oncol. 2004 May;24(5):1229-34.
Title: Smad2 mediates Erk1/2 activation by TGF-beta1 in suspended, but not in adherent, gastric carcinoma cells.
Author: Lee, Mi-Sook|Ko, Seong-Gyu|Kim, Hwang-Phill|Kim, Yong-Bae|Lee, Sung-Yul|Kim, Sang-Gyun|Jong, Hyun-Soon|Kim, Tae-You|Lee, Jung Weon|Bang, Yung-Jue
PMID: 15067346
Journal: Mol Cell Biol. 2005 Aug;25(16):6921-36.
Title: The signaling network of transforming growth factor beta1, protein kinase Cdelta, and integrin underlies the spreading and invasiveness of gastric carcinoma cells.
Author: Lee, Mi-Sook|Kim, Tae Young|Kim, Yong-Bae|Lee, Sung-Yul|Ko, Seong-Gyu|Jong, Hyun-Soon|Kim, Tae-You|Bang, Yung-Jue|Lee, Jung Weon
PMID: 16055706
Journal: World J Gastroenterol. 2006 May 21;12(19):3000-5.
Title: Selective inhibition of cell growth by activin in SNU-16 cells.
Author: Kim, Young-Il|Lee, Hee-Joo|Khang, Inkoo|Cho, Byung-Nam|Lee, Ha Kyu
PMID: 16718778
Journal: Dig Dis Sci. 2007 Jan;52(1):240-7. Epub 2006 Dec 14.
Title: Rebamipide inhibits gastric cancer cell growth.
Author: Tanigawa, Tetsuya|Pai, Rama|Arakawa, Tetsuo|Tarnawski, Andrzej S
PMID: 17171453
Journal: Histol Histopathol. 2008 Dec;23(12):1439-52.
Title: Extensive alteration in the expression profiles of TGFB pathway signaling components and TP53 is observed along the gastric dysplasia-carcinoma sequence.
Author: Kim, Seok-Hyung|Lee, Seung-Hyun|Choi, Yoon-La|Wang, Li-Hui|Park, Cheol Keun|Shin, Young Kee
PMID: 18830930
Journal: Cancer Sci. 2009 Oct;100(10):1809-16.
Title: c-Ski overexpression promotes tumor growth and angiogenesis through inhibition of transforming growth factor-beta signaling in diffuse-type gastric carcinoma.
Author: Kiyono, Kunihiko|Suzuki, Hiroshi I|Morishita, Yasuyuki|Komuro, Akiyoshi|Iwata, Caname|Yashiro, Masakazu|Hirakawa, Kosei|Kano, Mitsunobu R|Miyazono, Kohei
PMID: 19594546
Journal: Acta Biochim Biophys Sin (Shanghai). 2009 Aug;41(8):648-56.
Title: TGF-beta promotes invasion and metastasis of gastric cancer cells by increasing fascin1 expression via ERK and JNK signal pathways.
Author: Fu, Hua|Hu, Zhongliang|Wen, Jifang|Wang, Kuansong|Liu, Ying
PMID: 19657566
Journal: J Natl Cancer Inst. 2009 Apr 15;101(8):592-604.
Title: Diffuse-type gastric carcinoma: progression, angiogenesis, and transforming growth factor beta signaling.
Author: Komuro, Akiyoshi|Yashiro, Masakazu|Iwata, Caname|Morishita, Yasuyuki|Johansson, Erik|Matsumoto, Yoshiko|Watanabe, Akira|Aburatani, Hiroyuki|Miyoshi, Hiroyuki|Kiyono, Kunihiko|Shirai, Yo-taro|Suzuki, Hiroshi I|Hirakawa, Kosei|Kano, Mitsunobu R|Miyazono, Ko
PMID: 19351925
Journal: Int J Oncol. 2010 Feb;36(2):415-20.
Title: Integrative genomic analyses of CXCR4: transcriptional regulation of CXCR4 based on TGFbeta, Nodal, Activin signaling and POU5F1, FOXA2, FOXC2, FOXH1, SOX17, and GFI1 transcription factors.
Author: Katoh, Masuko|Katoh, Masaru
PMID: 20043076
Journal: Br J Cancer. 2010 Mar 2;102(5):844-51.
Title: Inhibitory effect of a TGFbeta receptor type-I inhibitor, Ki26894, on invasiveness of scirrhous gastric cancer cells.
Author: Shinto, O|Yashiro, M|Kawajiri, H|Shimizu, K|Shimizu, T|Miwa, A|Hirakawa, K
PMID: 20145621
Journal: Cancer Sci. 2010 Aug;101(8):1846-52.
Title: Combination effect of a TGF-beta receptor kinase inhibitor with 5-FU analog S1 on lymph node metastasis of scirrhous gastric cancer in mice.
Author: Shinto, Osamu|Yashiro, Masakazu|Kawajiri, Hidemi|Shimizu, Kiyoshi|Shimizu, Toshiyuki|Miwa, Atsushi|Hirakawa, Kosei
PMID: 20518790
Journal: BMC Cancer. 2010 Nov 26;10:652.
Title: Phosphorylated smad2 in advanced stage gastric carcinoma.
Author: Shinto, Osamu|Yashiro, Masakazu|Toyokawa, Takahiro|Nishii, Takafumi|Kaizaki, Ryoji|Matsuzaki, Taro|Noda, Satoru|Kubo, Naoshi|Tanaka, Hiroaki|Doi, Yosuke|Ohira, Masaichi|Muguruma, Kazuya|Sawada, Tetsuji|Hirakawa, Kosei
PMID: 21110833
Journal: Oncogene. 2011 Apr 7;30(14):1693-705.
Title: Transforming growth factor-beta decreases the cancer-initiating cell population within diffuse-type gastric carcinoma cells.
Author: Ehata, S|Johansson, E|Katayama, R|Koike, S|Watanabe, A|Hoshino, Y|Katsuno, Y|Komuro, A|Koinuma, D|Kano, M R|Yashiro, M|Hirakawa, K|Aburatani, H|Fujita, N|Miyazono, K
PMID: 21132002
Journal: Br J Cancer. 2011 Sep 27;105(7):996-1001.
Title: Upregulation of cancer-associated myofibroblasts by TGF-beta from scirrhous gastric carcinoma cells.
Author: Fuyuhiro, Y|Yashiro, M|Noda, S|Kashiwagi, S|Matsuoka, J|Doi, Y|Kato, Y|Hasegawa, T|Sawada, T|Hirakawa, K
PMID: 21863023
Journal: J Virol. 2011 Aug;85(15):7836-48.
Title: Transforming growth factor beta-induced reactivation of Epstein-Barr virus involves multiple Smad-binding elements cooperatively activating expression of the latent-lytic switch BZLF1 gene.
Author: Iempridee, Tawin|Das, Shreyasi|Xu, Iris|Mertz, Janet E
PMID: 21593157
Journal: Ann Surg Oncol. 2011 Dec;18(13):3718-25.
Title: Borrmann's macroscopic criteria and p-Smad2 expression are useful predictive prognostic markers for cytology-positive gastric cancer patients without overt peritoneal metastasis.
Author: Noda, Satoru|Yashiro, Masakazu|Toyokawa, Takahiro|Morimoto, Jyunya|Shinto, Osamu|Muguruma, Kazuya|Sawada, Tetsuji|Hirakawa, Kosei
PMID: 21573834
Journal: Exp Cell Res. 2011 Jun 10;317(10):1353-8.
Title: RNA interference targeting raptor inhibits proliferation of gastric cancer cells.
Author: Wu, William Ka Kei|Lee, Chung Wa|Cho, Chi Hin|Chan, Francis Ka Leung|Yu, Jun|Sung, Joseph Jao Yiu
PMID: 21396933
Journal: Int J Mol Med. 2011 Feb;27(2):187-93.
Title: Human peritoneal mesothelial cell transformation into myofibroblasts in response to TGF-ss1 in vitro.
Author: Lv, Zhi-Dong|Na, Di|Ma, Xiao-Yang|Zhao, Chong|Zhao, Wei-Jun|Xu, Hui-Mian
PMID: 21152863
Journal: Ann Surg Oncol. 2012 Apr;19(4):1350-6.
Title: Changes in myostatin signaling in non-weight-losing cancer patients.
Author: Aversa, Zaira|Bonetto, Andrea|Penna, Fabio|Costelli, Paola|Di Rienzo, Gaetano|Lacitignola, Angelo|Baccino, Francesco M|Ziparo, Vincenzo|Mercantini, Paolo|Rossi Fanelli, Filippo|Muscaritoli, Maurizio
PMID: 21519918
Journal: Int J Mol Med. 2012 Mar;29(3):373-9.
Title: TGF-beta1 induces peritoneal fibrosis by activating the Smad2 pathway in mesothelial cells and promotes peritoneal carcinomatosis.
Author: Lv, Zhi-Dong|Wang, Hai-Bo|Li, Fu-Nian|Wu, Li|Liu, Chen|Nie, Gang|Kong, Bin|Qu, Hui-Li|Li, Jian-Guo
PMID: 22139024
Journal: Cancer Sci. 2012 Apr;103(4):797-805.
Title: Cancer-associated orthotopic myofibroblasts stimulates the motility of gastric carcinoma cells.
Author: Fuyuhiro, Yuhiko|Yashiro, Masakazu|Noda, Satoru|Matsuoka, Junko|Hasegawa, Tsuyoshi|Kato, Yukihiro|Sawada, Tetsuji|Hirakawa, Kosei
PMID: 22320235
Journal: Oncol Rep. 2012 Jun;27(6):1960-6.
Title: microRNA-155 is downregulated in gastric cancer cells and involved in cell metastasis.
Author: Li, Cheng-Long|Nie, Hui|Wang, Ming|Su, Li-Ping|Li, Jian-Fang|Yu, Ying-Yan|Yan, Min|Qu, Qin-Long|Zhu, Zheng-Gang|Liu, Bing-Ya
PMID: 22426647
Journal: Oncol Rep. 2012 Jun;27(6):1753-8.
Title: The cytotoxic effect of TGF-beta1 on mesothelial cells via apoptosis in early peritoneal carcinomatosis.
Author: Lv, Zhi-Dong|Yang, Zhao-Chuan|Wang, Hai-Bo|Li, Jian-Guo|Kong, Bin|Wang, Xin-Gang|Liu, Xiao-Yi|Niu, Zhao-He|Wang, Yu|Nie, Gang
PMID: 22447164
Journal: PLoS One. 2012;7(4):e35684.
Title: Decreased levels of active SMAD2 correlate with poor prognosis in gastric cancer.
Author: Wu, Yijun|Li, Qi|Zhou, Xinhui|Yu, Jiren|Mu, Yunchuan|Munker, Stefan|Xu, Chengfu|Shen, Zhe|Mullenbach, Roman|Liu, Yan|Li, Li|Gretz, Norbert|Zieker, Derek|Li, Jun|Matsuzaki, Kouichi|Li, Youming|Dooley, Steven|Weng, Honglei
PMID: 22539990
Journal: World J Gastroenterol. 2012 Dec 28;18(48):7212-24.
Title: Comparative genomic study of gastric epithelial cells co-cultured with Helicobacter pylori.
Author: Wang, Fen|Luo, Li-Dan|Pan, Jian-Hua|Huang, Li-Hua|Lv, Hong-Wei|Guo, Qin|Xu, Can-Xia|Shen, Shou-Rong
PMID: 23326126
Journal: PLoS One. 2013;8(1):e54249.
Title: Transforming growth factor-beta1 and -beta2 in gastric precancer and cancer and roles in tumor-cell interactions with peripheral blood mononuclear cells in vitro.
Author: Ma, Gui-Fen|Miao, Qing|Zeng, Xiao-Qing|Luo, Tian-Cheng|Ma, Li-Li|Liu, Yi-Mei|Lian, Jing-Jing|Gao, Hong|Chen, Shi-Yao
PMID: 23342108
Journal: Tumour Biol. 2013 Dec;34(6):3705-12.
Title: microRNA-148a suppresses human gastric cancer cell metastasis by reversing epithelial-to-mesenchymal transition.
Author: Wang, Sui-Han|Li, Xu|Zhou, Li-Sheng|Cao, Zhong-Wei|Shi, Chao|Zhou, Chong-Zhi|Wen, Yu-Gang|Shen, Yang|Li, Ji-Kun
PMID: 23873106
Journal: Int J Oncol. 2013 Apr;42(4):1167-74.
Title: Low-dose paclitaxel modulates tumour fibrosis in gastric cancer.
Author: Tsukada, Tomoya|Fushida, Sachio|Harada, Shinichi|Terai, Shiroh|Yagi, Yasumichi|Kinoshita, Jun|Oyama, Katsunobu|Tajima, Hidehiro|Ninomiya, Itasu|Fujimura, Takashi|Ohta, Tetsuo
PMID: 23443842
Journal: Oncogene. 2014 Jun 26;33(26):3473-84.
Title: Oncogenic PAK4 regulates Smad2/3 axis involving gastric tumorigenesis.
Author: Wang, C|Li, Y|Zhang, H|Liu, F|Cheng, Z|Wang, D|Wang, G|Xu, H|Zhao, Y|Cao, L|Li, F
PMID: 23934187
Journal: Int J Cancer. 2014 Apr 15;134(8):1785-95.
Title: Cancer-associated fibroblasts might sustain the stemness of scirrhous gastric cancer cells via transforming growth factor-beta signaling.
Author: Hasegawa, Tsuyoshi|Yashiro, Masakazu|Nishii, Takafumi|Matsuoka, Junko|Fuyuhiro, Yuhiko|Morisaki, Tamami|Fukuoka, Tatsunari|Shimizu, Kiyoshi|Shimizu, Toshiyuki|Miwa, Atsushi|Hirakawa, Kosei
PMID: 24155219
Journal: J Surg Res. 2014 Jul;190(1):55-63.
Title: Oridonin inhibits hepatic stellate cell proliferation and fibrogenesis.
Author: Bohanon, Fredrick J|Wang, Xiaofu|Ding, Chunyong|Ding, Ye|Radhakrishnan, Geetha L|Rastellini, Cristiana|Zhou, Jia|Radhakrishnan, Ravi S
PMID: 24742622
Journal: Med Oncol. 2015 Jan;32(1):447.
Title: The unfolded protein response potentiates epithelial-to-mesenchymal transition (EMT) of gastric cancer cells under severe hypoxic conditions.
Author: Shen, Xinsheng|Xue, Yange|Si, Yaqing|Wang, Qun|Wang, Zhao|Yuan, Jiaxiang|Zhang, Xiefu
PMID: 25502090
Journal: Zhonghua Wei Chang Wai Ke Za Zhi. 2015 Jan;18(1):54-7.
Title: [Role of transforming growth factor-beta1 in epithelial-mesenchymal transition of mesothelial cells and its effect on peritoneal metastasis of gastric cancer].
Author: Lyu, Zhidong|Kong, Bin|Liu, Xiangping|Li, Funian|Wang, Haibo|Xu, Huimian
PMID: 25656033
Journal: BMC Cancer. 2015 Sep 15;15:637.
Title: Mitogen-activated protein kinase activator with WD40 repeats (MAWD) and MAWD-binding protein induce cell differentiation in gastric cancer.
Author: Li, Dongmei|Zhang, Jun|Xi, Yu|Zhang, Lei|Li, Wenmei|Cui, Jiantao|Xing, Rui|Pan, Yuanmin|Pan, Zemin|Li, Feng|Lu, Youyong
PMID: 26373288
Journal: Am J Transl Res. 2015 Nov 15;7(11):2262-9. eCollection 2015.
Title: Linc-POU3F3 promotes cell proliferation in gastric cancer via increasing T-reg distribution.
Author: Xiong, Guanying|Yang, Lihua|Chen, Yun|Fan, Zhining
PMID: 26807174
Journal: Oncogene. 2016 Apr 21;35(16):2133-44.
Title: Epigenetic silencing of GDF1 disrupts SMAD signaling to reinforce gastric cancer development.
Author: Yang, W|Mok, M T S|Li, M S M|Kang, W|Wang, H|Chan, A W|Chou, J-L|Chen, J|Ng, E K W|To, K-F|Yu, J|Chan, M W Y|Chan, F K L|Sung, J J Y|Cheng, A S L
PMID: 26212015
Journal: Cell Oncol (Dordr). 2016 Apr;39(2):129-37.
Title: PDCD2 and NCoR1 as putative tumor suppressors in gastric gastrointestinal stromal tumors.
Author: Wang, Wei|Song, Xiao-Wen|Bu, Xian-Min|Zhang, Ning|Zhao, Cheng-Hai
PMID: 26589942
Journal: Int J Oncol. 2016 May;48(5):1877-85.
Title: miR-148a downregulates the expression of transforming growth factor-beta2 and SMAD2 in gastric cancer.
Author: Zhang, Wei|Li, Yan
PMID: 26983401
Journal: Cell Physiol Biochem. 2016;39(2):453-66.
Title: Smad2/3/4 Pathway Contributes to TGF-beta-Induced MiRNA-181b Expression to Promote Gastric Cancer Metastasis by Targeting Timp3.
Author: Zhou, Qi|Zheng, Xiao|Chen, Lujun|Xu, Bin|Yang, Xin|Jiang, Jingting|Wu, Changping
PMID: 27383203
Journal: Int J Oncol. 2016 Dec;49(6):2520-2528.
Title: ADAM17 promotes epithelial-mesenchymal transition via TGF-beta/Smad pathway in gastric carcinoma cells.
Author: Xu, Min|Zhou, Hailang|Zhang, Chunli|He, Junbo|Wei, Hong|Zhou, Meng|Lu, Ying|Sun, Yaocheng|Ding, Jerry Wanming|Zeng, Jian|Peng, Wanxin|Du, Fengyi|Gong, Aihua
PMID: 27779657
Journal: Cancer Sci. 2017 Feb;108(2):178-186.
Title: High KRT8 expression promotes tumor progression and metastasis of gastric cancer.
Author: Fang, Jian|Wang, Hao|Liu, Yun|Ding, Fangfang|Ni, Ying|Shao, Shihe
PMID: 27865045
Journal: Evid Based Complement Alternat Med. 2017;2017:1871298.
Title: Yiqi Huayu Jiedu Decoction Inhibits the Invasion and Metastasis of Gastric Cancer Cells through TGF-beta/Smad Pathway.
Author: Wu, Ting-Ting|Lu, Jun|Zheng, Pei-Qiu|Liu, Shen-Lin|Wu, Jian|Sun, Wei|Sun, Qing-Min|Ma, Nai-Xia|Ding, Xue-Lian|Chen, Min|Zou, Xi
PMID: 28539961
Journal: Cancer Lett. 2017 Jul 10;398:52-61.
Title: ASPP2 suppresses invasion and TGF-beta1-induced epithelial-mesenchymal transition by inhibiting Smad7 degradation mediated by E3 ubiquitin ligase ITCH in gastric cancer.
Author: Gen, Yasuyuki|Yasui, Kohichiroh|Kitaichi, Tomoko|Iwai, Naoto|Terasaki, Kei|Dohi, Osamu|Hashimoto, Hikaru|Fukui, Hayato|Inada, Yutaka|Fukui, Akifumi|Jo, Masayasu|Moriguchi, Michihisa|Nishikawa, Taichiro|Umemura, Atushi|Yamaguchi, Kanji|Konishi, Hiroyuki|Na
PMID: 28400336
Journal: Onco Targets Ther. 2017 Mar 9;10:1503-1512.
Title: Silencing Trim59 inhibits invasion/migration and epithelial-to-mesenchymal transition via TGF-beta/Smad2/3 signaling pathway in bladder cancer cells.
Author: Chen, Wei|Zhao, Kai|Miao, Chenkui|Xu, Aiming|Zhang, Jianzhong|Zhu, Jundong|Su, Shifeng|Wang, Zengjun
PMID: 28331343
Journal: Eur Rev Med Pharmacol Sci. 2017 Jan;21(2):258-265.
Title: HOXA13 upregulation in gastric cancer is associated with enhanced cancer cell invasion and epithelial-to-mesenchymal transition.
Author: He, Y-X|Song, X-H|Zhao, Z-Y|Zhao, H
PMID: 28165563
Journal: Gene. 2017 Mar 20;605:63-69.
Title: Upregulation of microRNA-574-3p in a human gastric cancer cell line AGS by TGF-beta1.
Author: Zhang, Renwen|Wang, Mingqi|Sui, Pengcheng|Ding, Lei|Yang, Qing
PMID: 28042090
Journal: Gastric Cancer. 2018 Jan;21(1):55-67.
Title: Importance of human peritoneal mesothelial cells in the progression, fibrosis, and control of gastric cancer: inhibition of growth and fibrosis by tranilast.
Author: Saito, Hiroto|Fushida, Sachio|Harada, Shinichi|Miyashita, Tomoharu|Oyama, Katsunobu|Yamaguchi, Takahisa|Tsukada, Tomoya|Kinoshita, Jun|Tajima, Hidehiro|Ninomiya, Itasu|Ohta, Tetsuo
PMID: 28540637
Journal: Mol Cell Biochem. 2018 Jun;443(1-2):93-100.
Title: Knockdown of IARS2 suppressed growth of gastric cancer cells by regulating the phosphorylation of cell cycle-related proteins.
Author: Fang, Zheng|Wang, Xingyu|Yan, Qiang|Zhang, Shangxin|Li, Yongxiang
PMID: 29071539
Journal: Cell Death Dis. 2018 Jan 18;9(2):27.
Title: PCDHGA9 acts as a tumor suppressor to induce tumor cell apoptosis and autophagy and inhibit the EMT process in human gastric cancer.
Author: Weng, Junyong|Xiao, Jingbo|Mi, Yushuai|Fang, Xu|Sun, Yahuang|Li, Shanbao|Qin, Zhiwei|Li, Xu|Liu, Tingting|Zhao, Senlin|Zhou, Lisheng|Wen, Yugang
PMID: 29348665
Journal: Biomed Pharmacother. 2018 May;101:355-361.
Title: Sauchinone prevents TGF-beta-induced EMT and metastasis in gastric cancer cells.
Author: He, Zhikuan|Dong, Wenxing|Li, Quanying|Qin, Changjiang|Li, Yongjun
PMID: 29499410
Journal: Cell Death Dis. 2018 May 29;9(6):649.
Title: DSGOST regulates resistance via activation of autophagy in gastric cancer.
Author: Kim, Tae Woo|Lee, Seon Young|Kim, Mia|Cheon, Chunhoo|Jang, Bo-Hyoung|Shin, Yong Cheol|Ko, Seong-Gyu
PMID: 29844404
Journal: Onco Targets Ther. 2018 Jul 12;11:4001-4017.
Title: MFAP2 promotes epithelial-mesenchymal transition in gastric cancer cells by activating TGF-beta/SMAD2/3 signaling pathway.
Author: Wang, Jian-Kai|Wang, Wen-Juan|Cai, Hong-Yi|Du, Bin-Bin|Mai, Ping|Zhang, Li-Juan|Ma, Wen|Hu, Yong-Guo|Feng, Shi-Fang|Miao, Guo-Ying
PMID: 30034240
Journal: Cell Death Dis. 2018 Aug 28;9(9):849.
Title: TGF-beta1-SOX9 axis-inducible COL10A1 promotes invasion and metastasis in gastric cancer via epithelial-to-mesenchymal transition.
Author: Li, Tingting|Huang, Haipeng|Shi, Guangyao|Zhao, Liying|Li, Tuanjie|Zhang, Ze|Liu, Ruoyan|Hu, Yanfeng|Liu, Hao|Yu, Jiang|Li, Guoxin
PMID: 30154451