Primary Site >> Stomach Cancer
Gene >> SMAD2
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Ref: No mutations of the Smad2 gene in human sporadic gastric carcinomas. PMID: 10073143 |
Ref: Functions of mammalian Smad genes as revealed by targeted gene disruption in mice. PMID: 10708952 |
Ref: Interferon-gamma suppresses transforming growth factor-beta-induced invasion of gastric carcinoma cells through cross-talk of Smad pathway in a three-dimensional culture model. PMID: 14586410 |
Ref: Smad2 mediates Erk1/2 activation by TGF-beta1 in suspended, but not in adherent, gastric carcinoma cells. PMID: 15067346 |
Ref: The signaling network of transforming growth factor beta1, protein kinase Cdelta, and integrin underlies the spreading and invasiveness of gastric carcinoma cells. PMID: 16055706 |
Ref: Selective inhibition of cell growth by activin in SNU-16 cells. PMID: 16718778 |
Ref: Rebamipide inhibits gastric cancer cell growth. PMID: 17171453 |
Ref: Extensive alteration in the expression profiles of TGFB pathway signaling components and TP53 is observed along the gastric dysplasia-carcinoma sequence. PMID: 18830930 |
Ref: Diffuse-type gastric carcinoma: progression, angiogenesis, and transforming growth factor beta signaling. PMID: 19351925 Ref: c-Ski overexpression promotes tumor growth and angiogenesis through inhibition of transforming growth factor-beta signaling in diffuse-type gastric carcinoma. PMID: 19594546 Ref: TGF-beta promotes invasion and metastasis of gastric cancer cells by increasing fascin1 expression via ERK and JNK signal pathways. PMID: 19657566 |
Ref: Integrative genomic analyses of CXCR4: transcriptional regulation of CXCR4 based on TGFbeta, Nodal, Activin signaling and POU5F1, FOXA2, FOXC2, FOXH1, SOX17, and GFI1 transcription factors. PMID: 20043076 Ref: Inhibitory effect of a TGFbeta receptor type-I inhibitor, Ki26894, on invasiveness of scirrhous gastric cancer cells. PMID: 20145621 Ref: Combination effect of a TGF-beta receptor kinase inhibitor with 5-FU analog S1 on lymph node metastasis of scirrhous gastric cancer in mice. PMID: 20518790 Ref: Phosphorylated smad2 in advanced stage gastric carcinoma. PMID: 21110833 |
Ref: Transforming growth factor-beta decreases the cancer-initiating cell population within diffuse-type gastric carcinoma cells. PMID: 21132002 Ref: Human peritoneal mesothelial cell transformation into myofibroblasts in response to TGF-ss1 in vitro. PMID: 21152863 Ref: RNA interference targeting raptor inhibits proliferation of gastric cancer cells. PMID: 21396933 Ref: Borrmann's macroscopic criteria and p-Smad2 expression are useful predictive prognostic markers for cytology-positive gastric cancer patients without overt peritoneal metastasis. PMID: 21573834 Ref: Transforming growth factor beta-induced reactivation of Epstein-Barr virus involves multiple Smad-binding elements cooperatively activating expression of the latent-lytic switch BZLF1 gene. PMID: 21593157 Ref: Upregulation of cancer-associated myofibroblasts by TGF-beta from scirrhous gastric carcinoma cells. PMID: 21863023 |
Ref: Changes in myostatin signaling in non-weight-losing cancer patients. PMID: 21519918 Ref: TGF-beta1 induces peritoneal fibrosis by activating the Smad2 pathway in mesothelial cells and promotes peritoneal carcinomatosis. PMID: 22139024 Ref: Cancer-associated orthotopic myofibroblasts stimulates the motility of gastric carcinoma cells. PMID: 22320235 Ref: microRNA-155 is downregulated in gastric cancer cells and involved in cell metastasis. PMID: 22426647 Ref: The cytotoxic effect of TGF-beta1 on mesothelial cells via apoptosis in early peritoneal carcinomatosis. PMID: 22447164 Ref: Decreased levels of active SMAD2 correlate with poor prognosis in gastric cancer. PMID: 22539990 Ref: Comparative genomic study of gastric epithelial cells co-cultured with Helicobacter pylori. PMID: 23326126 |
Ref: Transforming growth factor-beta1 and -beta2 in gastric precancer and cancer and roles in tumor-cell interactions with peripheral blood mononuclear cells in vitro. PMID: 23342108 Ref: Low-dose paclitaxel modulates tumour fibrosis in gastric cancer. PMID: 23443842 Ref: microRNA-148a suppresses human gastric cancer cell metastasis by reversing epithelial-to-mesenchymal transition. PMID: 23873106 |
Ref: Oncogenic PAK4 regulates Smad2/3 axis involving gastric tumorigenesis. PMID: 23934187 Ref: Cancer-associated fibroblasts might sustain the stemness of scirrhous gastric cancer cells via transforming growth factor-beta signaling. PMID: 24155219 Ref: Oridonin inhibits hepatic stellate cell proliferation and fibrogenesis. PMID: 24742622 |
Ref: The unfolded protein response potentiates epithelial-to-mesenchymal transition (EMT) of gastric cancer cells under severe hypoxic conditions. PMID: 25502090 Ref: [Role of transforming growth factor-beta1 in epithelial-mesenchymal transition of mesothelial cells and its effect on peritoneal metastasis of gastric cancer]. PMID: 25656033 Ref: Mitogen-activated protein kinase activator with WD40 repeats (MAWD) and MAWD-binding protein induce cell differentiation in gastric cancer. PMID: 26373288 Ref: Linc-POU3F3 promotes cell proliferation in gastric cancer via increasing T-reg distribution. PMID: 26807174 |
Ref: Epigenetic silencing of GDF1 disrupts SMAD signaling to reinforce gastric cancer development. PMID: 26212015 Ref: PDCD2 and NCoR1 as putative tumor suppressors in gastric gastrointestinal stromal tumors. PMID: 26589942 Ref: miR-148a downregulates the expression of transforming growth factor-beta2 and SMAD2 in gastric cancer. PMID: 26983401 Ref: Smad2/3/4 Pathway Contributes to TGF-beta-Induced MiRNA-181b Expression to Promote Gastric Cancer Metastasis by Targeting Timp3. PMID: 27383203 Ref: ADAM17 promotes epithelial-mesenchymal transition via TGF-beta/Smad pathway in gastric carcinoma cells. PMID: 27779657 |
Ref: High KRT8 expression promotes tumor progression and metastasis of gastric cancer. PMID: 27865045 Ref: Upregulation of microRNA-574-3p in a human gastric cancer cell line AGS by TGF-beta1. PMID: 28042090 Ref: HOXA13 upregulation in gastric cancer is associated with enhanced cancer cell invasion and epithelial-to-mesenchymal transition. PMID: 28165563 Ref: Silencing Trim59 inhibits invasion/migration and epithelial-to-mesenchymal transition via TGF-beta/Smad2/3 signaling pathway in bladder cancer cells. PMID: 28331343 Ref: ASPP2 suppresses invasion and TGF-beta1-induced epithelial-mesenchymal transition by inhibiting Smad7 degradation mediated by E3 ubiquitin ligase ITCH in gastric cancer. PMID: 28400336 Ref: Yiqi Huayu Jiedu Decoction Inhibits the Invasion and Metastasis of Gastric Cancer Cells through TGF-beta/Smad Pathway. PMID: 28539961 |
Ref: Importance of human peritoneal mesothelial cells in the progression, fibrosis, and control of gastric cancer: inhibition of growth and fibrosis by tranilast. PMID: 28540637 Ref: Knockdown of IARS2 suppressed growth of gastric cancer cells by regulating the phosphorylation of cell cycle-related proteins. PMID: 29071539 Ref: PCDHGA9 acts as a tumor suppressor to induce tumor cell apoptosis and autophagy and inhibit the EMT process in human gastric cancer. PMID: 29348665 Ref: Sauchinone prevents TGF-beta-induced EMT and metastasis in gastric cancer cells. PMID: 29499410 Ref: DSGOST regulates resistance via activation of autophagy in gastric cancer. PMID: 29844404 Ref: MFAP2 promotes epithelial-mesenchymal transition in gastric cancer cells by activating TGF-beta/SMAD2/3 signaling pathway. PMID: 30034240 Ref: TGF-beta1-SOX9 axis-inducible COL10A1 promotes invasion and metastasis in gastric cancer via epithelial-to-mesenchymal transition. PMID: 30154451 |