Primary Site >> Pancreatic Cancer

Gene >> SLC39A4

Journal: Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18636-41. Epub 2007 Nov 14.
Title: Aberrant expression of zinc transporter ZIP4 (SLC39A4) significantly contributes to human pancreatic cancer pathogenesis and progression.
Author: Li, Min|Zhang, Yuqing|Liu, Zijuan|Bharadwaj, Uddalak|Wang, Hao|Wang, Xinwen|Zhang, Sheng|Liuzzi, Juan P|Chang, Shou-Mei|Cousins, Robert J|Fisher, William E|Brunicardi, F Charles|Logsdon, Craig D|Chen, Changyi|Yao, Qizhi
PMID: 18003899
Journal: Clin Cancer Res. 2009 Oct 1;15(19):5993-6001.
Title: Down-regulation of ZIP4 by RNA interference inhibits pancreatic cancer growth and increases the survival of nude mice with pancreatic cancer xenografts.
Author: Li, Min|Zhang, Yuqing|Bharadwaj, Uddalak|Zhai, Qihui Jim|Ahern, Charlotte H|Fisher, William E|Brunicardi, F Charles|Logsdon, Craig D|Chen, Changyi|Yao, Qizhi
PMID: 19755388
Journal: Cancer Biol Ther. 2010 Feb;9(3):236-42. Epub 2010 Feb 25.
Title: ZIP4 upregulates the expression of neuropilin-1, vascular endothelial growth factor, and matrix metalloproteases in pancreatic cancer cell lines and xenografts.
Author: Zhang, Yuqing|Chen, Changyi|Yao, Qizhi|Li, Min
PMID: 20023433
Journal: Clin Cancer Res. 2010 Mar 1;16(5):1423-30.
Title: ZIP4 regulates pancreatic cancer cell growth by activating IL-6/STAT3 pathway through zinc finger transcription factor CREB.
Author: Zhang, Yuqing|Bharadwaj, Uddalak|Logsdon, Craig D|Chen, Changyi|Yao, Qizhi|Li, Min
PMID: 20160059
Journal: PLoS One. 2010 Oct 4;5(10).
Title: Zip4 (Slc39a4) expression is activated in hepatocellular carcinomas and functions to repress apoptosis, enhance cell cycle and increase migration.
Author: Weaver, Benjamin P|Zhang, Yuxia|Hiscox, Stephen|Guo, Grace L|Apte, Udayan|Taylor, Kathryn M|Sheline, Christian T|Wang, Li|Andrews, Glen K
PMID: 20957146
Journal: Curr Mol Med. 2012 Mar;12(3):331-41.
Title: Genomic sequencing of key genes in mouse pancreatic cancer cells.
Author: Wang, Y|Zhang, Y|Yang, J|Ni, X|Liu, S|Li, Z|Hodges, S E|Fisher, W E|Brunicardi, F C|Gibbs, R A|Gingras, M-C|Li, M
PMID: 22208613
Journal: Curr Mol Med. 2013 Mar;13(3):401-9.
Title: Gene profile identifies zinc transporters differentially expressed in normal human organs and human pancreatic cancer.
Author: Yang, J|Zhang, Y|Cui, X|Yao, W|Yu, X|Cen, P|Hodges, S E|Fisher, W E|Brunicardi, F C|Chen, C|Yao, Q|Li, M
PMID: 23331012
Journal: EMBO Mol Med. 2013 Sep;5(9):1322-34.
Title: A novel epigenetic CREB-miR-373 axis mediates ZIP4-induced pancreatic cancer growth.
Author: Zhang, Yuqing|Yang, Jingxuan|Cui, Xiaobo|Chen, Yong|Zhu, Vivian F|Hagan, John P|Wang, Huamin|Yu, Xianjun|Hodges, Sally E|Fang, Jing|Chiao, Paul J|Logsdon, Craig D|Fisher, William E|Brunicardi, F Charles|Chen, Changyi|Yao, Qizhi|Fernandez-Zapico, Martin E|
PMID: 23857777
Journal: Curr Mol Med. 2014 Mar;14(3):309-15.
Title: ZIP4 is a novel diagnostic and prognostic marker in human pancreatic cancer: a systemic comparison between EUS-FNA and surgical specimens.
Author: Xu, C|Wallace, M B|Yang, J|Jiang, L|Zhai, Q|Zhang, Y|Hong, C|Chen, Y|Frank, T S|Stauffer, J A|Asbun, H J|Raimondo, M|Woodward, T A|Li, Z|Guha, S|Zheng, L|Li, M
PMID: 24345208
Journal: Cell Cycle. 2014;13(7):1180-6.
Title: ZIP4 confers resistance to zinc deficiency-induced apoptosis in pancreatic cancer.
Author: Cui, Xiaobo|Zhang, Yuqing|Yang, Jingxuan|Sun, Xiaotian|Hagan, John P|Guha, Sushovan|Li, Min
PMID: 24553114
Journal: Int J Biol Sci. 2014 Feb 11;10(3):245-56.
Title: ZIP4, a novel determinant of tumor invasion in hepatocellular carcinoma, contributes to tumor recurrence after liver transplantation.
Author: Xu, Xiao|Guo, Hai-Jun|Xie, Hai-Yang|Li, Jie|Zhuang, Run-Zhou|Ling, Qi|Zhou, Lin|Wei, Xu-Yong|Liu, Zhi-Kun|Ding, Song-Ming|Chen, Kang-Jie|Xu, Zhi-Yuan|Zheng, Shu-Sen
PMID: 24643086
Journal: Hepatobiliary Pancreat Dis Int. 2014 Aug;13(4):371-80.
Title: Interleukin-6: a villain in the drama of pancreatic cancer development and progression.
Author: Holmer, Reinhild|Goumas, Freya A|Waetzig, Georg H|Rose-John, Stefan|Kalthoff, Holger
PMID: 25100121
Journal: Oncotarget. 2015 Sep 22;6(28):26041-51.
Title: ZIP4 silencing improves bone loss in pancreatic cancer.
Author: Zhang, Qiang|Sun, Xiaotian|Yang, Jingxuan|Ding, Hao|LeBrun, Drake|Ding, Kai|Houchen, Courtney W|Postier, Russell G|Ambrose, Catherine G|Li, Zhaoshen|Bi, Xiaohong|Li, Min
PMID: 26305676
Journal: Clin Cancer Res. 2018 Jul 1;24(13):3186-3196.
Title: ZIP4 Promotes Pancreatic Cancer Progression by Repressing ZO-1 and Claudin-1 through a ZEB1-Dependent Transcriptional Mechanism.
Author: Liu, Mingyang|Yang, Jingxuan|Zhang, Yuqing|Zhou, Zhijun|Cui, Xiaobo|Zhang, Liyang|Fung, Kar-Ming|Zheng, Wei|Allard, Felicia D|Yee, Eric U|Ding, Kai|Wu, Huanwen|Liang, Zhiyong|Zheng, Lei|Fernandez-Zapico, Martin E|Li, Yi-Ping|Bronze, Michael S|Morris, Kath
PMID: 29615456
Journal: Cancer Sci. 2018 Sep;109(9):2946-2956.
Title: Exosomal zinc transporter ZIP4 promotes cancer growth and is a novel diagnostic biomarker for pancreatic cancer.
Author: Jin, Haoyi|Liu, Peng|Wu, Yunhao|Meng, Xiangli|Wu, Mengwei|Han, Jiahong|Tan, Xiaodong
PMID: 30007115
Journal: Gastroenterology. 2018 Oct 17. pii: S0016-5085(18)35157-6.
Title: ZIP4 Promotes Muscle Wasting and Cachexia in Mice with Orthotopic Pancreatic Tumors by Stimulating RAB27B-Regulated Release of Extracellular Vesicles From Cancer Cells.
Author: Yang, Jingxuan|Zhang, Zicheng|Zhang, Yuqing|Ni, Xiaoling|Zhang, Guohua|Cui, Xiaobo|Liu, Mingyang|Xu, Can|Zhang, Qiang|Zhu, Huiyun|Yan, Jie|Zhu, Vivian F|Luo, Yusheng|Hagan, John P|Li, Zhaoshen|Fang, Jing|Jatoi, Aminah|Fernandez-Zapico, Martin E|Zheng, Lei
PMID: 30342032