Primary Site >> Pancreatic Cancer

Gene >> SLC39A4

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Ref: Aberrant expression of zinc transporter ZIP4 (SLC39A4) significantly contributes to human pancreatic cancer pathogenesis and progression.
PMID: 18003899
 Ref: Down-regulation of ZIP4 by RNA interference inhibits pancreatic cancer growth and increases the survival of nude mice with pancreatic cancer xenografts.
PMID: 19755388
 Ref: ZIP4 upregulates the expression of neuropilin-1, vascular endothelial growth factor, and matrix metalloproteases in pancreatic cancer cell lines and xenografts.
PMID: 20023433
Ref: ZIP4 regulates pancreatic cancer cell growth by activating IL-6/STAT3 pathway through zinc finger transcription factor CREB.
PMID: 20160059
Ref: Zip4 (Slc39a4) expression is activated in hepatocellular carcinomas and functions to repress apoptosis, enhance cell cycle and increase migration.
PMID: 20957146
 Ref: Genomic sequencing of key genes in mouse pancreatic cancer cells.
PMID: 22208613
 Ref: Gene profile identifies zinc transporters differentially expressed in normal human organs and human pancreatic cancer.
PMID: 23331012
Ref: A novel epigenetic CREB-miR-373 axis mediates ZIP4-induced pancreatic cancer growth.
PMID: 23857777
 Ref: ZIP4 is a novel diagnostic and prognostic marker in human pancreatic cancer: a systemic comparison between EUS-FNA and surgical specimens.
PMID: 24345208
Ref: ZIP4 confers resistance to zinc deficiency-induced apoptosis in pancreatic cancer.
PMID: 24553114
Ref: ZIP4, a novel determinant of tumor invasion in hepatocellular carcinoma, contributes to tumor recurrence after liver transplantation.
PMID: 24643086
Ref: Interleukin-6: a villain in the drama of pancreatic cancer development and progression.
PMID: 25100121
 Ref: ZIP4 silencing improves bone loss in pancreatic cancer.
PMID: 26305676
 Ref: ZIP4 Promotes Pancreatic Cancer Progression by Repressing ZO-1 and Claudin-1 through a ZEB1-Dependent Transcriptional Mechanism.
PMID: 29615456
Ref: Exosomal zinc transporter ZIP4 promotes cancer growth and is a novel diagnostic biomarker for pancreatic cancer.
PMID: 30007115
Ref: ZIP4 Promotes Muscle Wasting and Cachexia in Mice with Orthotopic Pancreatic Tumors by Stimulating RAB27B-Regulated Release of Extracellular Vesicles From Cancer Cells.
PMID: 30342032