Primary Site >> Colorectal Cancer

Gene >> SKP2

Journal: Cancer. 2001 May 1;91(9):1745-51.
Title: Inverse relation between levels of p27(Kip1) and of its ubiquitin ligase subunit Skp2 in colorectal carcinomas.
Author: Hershko, D|Bornstein, G|Ben-Izhak, O|Carrano, A|Pagano, M|Krausz, M M|Hershko, A
PMID: 11335900
Journal: Cancer. 2004 Apr 15;100(8):1615-21.
Title: Alterations in the expression of the cell cycle regulatory protein cyclin kinase subunit 1 in colorectal carcinoma.
Author: Shapira, Ma'anit|Ben-Izhak, Ofer|Bishara, Bishara|Futerman, Boris|Minkov, Ira|Krausz, Michael M|Pagano, Michele|Hershko, Dan D
PMID: 15073847
Journal: Int J Oncol. 2004 Jul;25(1):87-95.
Title: Correlation of Skp2 with carcinogenesis, invasion, metastasis, and prognosis in colorectal tumors.
Author: Li, Jia-Qing|Wu, Fei|Masaki, Tsutomu|Kubo, Akihito|Fujita, Jiro|Dixon, Dan A|Beauchamp, R Daniel|Ishida, Toshihiko|Kuriyama, Shigeki|Imaida, Katsumi
PMID: 15201993
Journal: Cancer. 2005 Apr 1;103(7):1336-46.
Title: The prognostic impact of the ubiquitin ligase subunits Skp2 and Cks1 in colorectal carcinoma.
Author: Shapira, Ma'anit|Ben-Izhak, Ofer|Linn, Shai|Futerman, Boris|Minkov, Ira|Hershko, Dan D
PMID: 15717322
Journal: Cancer. 2006 Aug 15;107(4):668-75.
Title: Prognostic role of p27Kip1 deregulation in colorectal cancer.
Author: Hershko, Dan D|Shapira, Ma'anit
PMID: 16826582
Journal: Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):14009-14.
Title: Testing the importance of p27 degradation by the SCFskp2 pathway in murine models of lung and colon cancer.
Author: Timmerbeul, Inke|Garrett-Engele, Carrie M|Kossatz, Uta|Chen, Xueyan|Firpo, Eduardo|Grunwald, Viktor|Kamino, Kenji|Wilkens, Ludwig|Lehmann, Ulrich|Buer, Jan|Geffers, Robert|Kubicka, Stefan|Manns, Michael P|Porter, Peggy L|Roberts, James M|Malek, Nisar P
PMID: 16966613
Journal: Mol Cancer. 2007 Jan 3;6:2.
Title: Gene expression profiles of primary colorectal carcinomas, liver metastases, and carcinomatoses.
Author: Kleivi, Kristine|Lind, Guro E|Diep, Chieu B|Meling, Gunn I|Brandal, Lin T|Nesland, Jahn M|Myklebost, Ola|Rognum, Torleiv O|Giercksky, Karl-Erik|Skotheim, Rolf I|Lothe, Ragnhild A
PMID: 17201907
Journal: Cancer Biol Ther. 2007 Apr;6(4):525-33.
Title: High copy amplification of the Aurora-A gene is associated with chromosomal instability phenotype in human colorectal cancers.
Author: Nishida, Naoshi|Nagasaka, Takeshi|Kashiwagi, Kazuhiro|Boland, C Richard|Goel, Ajay
PMID: 17457043
Journal: Cell Death Differ. 2008 May;15(5):908-19.
Title: p27 Kip1 nuclear localization and cyclin-dependent kinase inhibitory activity are regulated by glycogen synthase kinase-3 in human colon cancer cells.
Author: Wang, Q|Zhou, Y|Wang, X|Evers, B M
PMID: 18408738
Journal: Cancer Res. 2008 May 1;68(9):3379-88.
Title: Bortezomib (Velcade) induces p27Kip1 expression through S-phase kinase protein 2 degradation in colorectal cancer.
Author: Uddin, Shahab|Ahmed, Maqbool|Bavi, Prashant|El-Sayed, Raafat|Al-Sanea, Nasser|AbdulJabbar, Alaa|Ashari, Luai H|Alhomoud, Samar|Al-Dayel, Fouad|Hussain, Azhar R|Al-Kuraya, Khawla S
PMID: 18451165
Journal: Am J Pathol. 2008 Jul;173(1):217-28.
Title: Regulation of Skp2-p27 axis by the Cdh1/anaphase-promoting complex pathway in colorectal tumorigenesis.
Author: Fujita, Takeo|Liu, Weijun|Doihara, Hiroyoshi|Wan, Yong
PMID: 18535175
Journal: Cancer Res. 2009 Aug 1;69(15):6100-6.
Title: Tumor repressive functions of estrogen receptor beta in SW480 colon cancer cells.
Author: Hartman, Johan|Edvardsson, Karin|Lindberg, Karolina|Zhao, Chunyan|Williams, Cecilia|Strom, Anders|Gustafsson, Jan-Ake
PMID: 19602591
Journal: J Biol Chem. 2010 Mar 12;285(11):7995-8002.
Title: Foxp3 expression in p53-dependent DNA damage responses.
Author: Jung, Da-Jung|Jin, Dong-Hoon|Hong, Seung-Woo|Kim, Jee-Eun|Shin, Jae-Sik|Kim, Daejin|Cho, Byung-Joo|Hwang, Young-Il|Kang, Jae-Seung|Lee, Wang-Jae
PMID: 20075077
Journal: Mol Cancer Res. 2010 May;8(5):798-805.
Title: STAT1 represses Skp2 gene transcription to promote p27Kip1 stabilization in Ras-transformed cells.
Author: Wang, Shuo|Raven, Jennifer F|Koromilas, Antonis E
PMID: 20407011
Journal: Med Hypotheses. 2011 May;76(5):697-9.
Title: Modulation of liver X receptor signaling as a prevention and therapy for colon cancer.
Author: Chuu, Chih-Pin
PMID: 21333456
Journal: Oncogene. 2012 Sep 13;31(37):4128-38.
Title: Involvement of the SKP2-p27(KIP1) pathway in suppression of cancer cell proliferation by RECK.
Author: Yoshida, Y|Ninomiya, K|Hamada, H|Noda, M
PMID: 22158033
Journal: Cancer Gene Ther. 2013 Dec;20(12):690-4.
Title: S-phase kinase-associated protein 2 knockdown blocks colorectal cancer growth via regulation of both p27 and p16 expression.
Author: Xu, S-Y|Wang, F|Wei, G|Wang, B|Yang, J-Y|Huang, Y-Z|Zhang, L|Zheng, F|Guo, L-Y|Wang, J-N|Tang, J-M
PMID: 24336114
Journal: Int J Oncol. 2013 Dec;43(6):1967-75.
Title: Notch1-dependent regulation of p27 determines cell fate in colorectal cancer.
Author: Hristova, Nevyana R|Tagscherer, Katrin E|Fassl, Anne|Kopitz, Juergen|Roth, Wilfried
PMID: 24141420
Journal: Mol Carcinog. 2013 Nov;52(11):835-44.
Title: The oxysterol receptors LXRalpha and LXRbeta suppress proliferation in the colon.
Author: Vedin, Lise-Lotte|Gustafsson, Jan-Ake|Steffensen, Knut R
PMID: 22610535
Journal: Tumour Biol. 2013 Apr;34(2):1107-17.
Title: SKP2 overexpression is associated with a poor prognosis of rectal cancer treated with chemoradiotherapy and represents a therapeutic target with high potential.
Author: Tian, Yu-Feng|Chen, Tzu-Ju|Lin, Ching-Yih|Chen, Li-Tzong|Lin, Li-Ching|Hsing, Chung-Hsi|Lee, Sung-Wei|Sheu, Ming-Jen|Lee, Hao-Hsien|Shiue, Yow-Ling|Huang, Hsuan-Ying|Pan, Hsin-Yi|Li, Chien-Feng|Chen, Shang-Hung
PMID: 23328995
Journal: Mol Med Rep. 2014 Aug;10(2):1129-35.
Title: Interference of Skp2 effectively inhibits the development and metastasis of colon carcinoma.
Author: Chen, Haijin|Mo, Xiaodong|Yu, Jinlong|Huang, Shuxin|Huang, Zonghai|Gao, Liping
PMID: 24913024
Journal: Mol Cancer Ther. 2014 Oct;13(10):2303-14.
Title: The CREB-binding protein inhibitor ICG-001 suppresses pancreatic cancer growth.
Author: Arensman, Michael D|Telesca, Donatello|Lay, Anna R|Kershaw, Kathleen M|Wu, Nanping|Donahue, Timothy R|Dawson, David W
PMID: 25082960
Journal: Int J Oncol. 2015 Jan;46(1):113-22.
Title: Downregulation of thymidylate synthase and E2F1 by arsenic trioxide in mesothelioma.
Author: Lam, Sze-Kwan|Li, Yuan-Yuan|Zheng, Chun-Yan|Ho, James Chung-Man
PMID: 25335113
Journal: Cancer Chemother Pharmacol. 2015 Feb;75(2):411-20.
Title: Cks1 proteasomal degradation is induced by inhibiting Hsp90-mediated chaperoning in cancer cells.
Author: Khattar, Vinayak|Fried, Joshua|Xu, Bo|Thottassery, Jaideep V
PMID: 25544127
Journal: RNA Biol. 2015;12(3):276-89.
Title: microRNA-200b and microRNA-200c promote colorectal cancer cell proliferation via targeting the reversion-inducing cysteine-rich protein with Kazal motifs.
Author: Pan, Yi|Liang, Hongwei|Chen, Weixu|Zhang, Hongjie|Wang, Nan|Wang, Feng|Zhang, Suyang|Liu, Yanqing|Zhao, Chihao|Yan, Xin|Zhang, Junfeng|Zhang, Chen-Yu|Gu, Hongwei|Zen, Ke|Chen, Xi
PMID: 25826661
Journal: J Gastrointestin Liver Dis. 2015 Jun;24(2):225-34.
Title: The role of Skp2 and its substrate CDKN1B (p27) in colorectal cancer.
Author: Bochis, Ovidiu V|Irimie, Alexandru|Pichler, Martin|Berindan-Neagoe, Ioana
PMID: 26114183
Journal: J Nat Prod. 2015 Dec 24;78(12):2983-93.
Title: Antitumor Activity of Americanin A Isolated from the Seeds of Phytolacca americana by Regulating the ATM/ATR Signaling Pathway and the Skp2-p27 Axis in Human Colon Cancer Cells.
Author: Jung, Cholomi|Hong, Ji-Young|Bae, Song Yi|Kang, Sam Sik|Park, Hyen Joo|Lee, Sang Kook
PMID: 26595875
Journal: Oncotarget. 2016 Sep 13;7(37):58931-58938.
Title: Downregulated long non-coding RNA CLMAT3 promotes the proliferation of colorectal cancer cells by targeting regulators of the cell cycle pathway.
Author: Ye, Le-Chi|Chen, Tao|Zhu, De-Xiang|Lv, Shi-Xu|Qiu, Jun-Jun|Xu, Jianmin|Yuan, Feng-Lai|Wei, Ye
PMID: 27391344
Journal: Sci Rep. 2016 Jul 15;6:29869.
Title: Copy number variation of E3 ubiquitin ligase genes in peripheral blood leukocyte and colorectal cancer.
Author: Bi, Haoran|Tian, Tian|Zhu, Lin|Zhou, Haibo|Hu, Hanqing|Liu, Yanhong|Li, Xia|Hu, Fulan|Zhao, Yashuang|Wang, Guiyu
PMID: 27417709
Journal: Sci Rep. 2017 Apr 4;7(1):641.
Title: Integrated analysis of gene expression and copy number identified potential cancer driver genes with amplification-dependent overexpression in 1,454 solid tumors.
Author: Ohshima, Keiichi|Hatakeyama, Keiichi|Nagashima, Takeshi|Watanabe, Yuko|Kanto, Kaori|Doi, Yuki|Ide, Tomomi|Shimoda, Yuji|Tanabe, Tomoe|Ohnami, Sumiko|Ohnami, Shumpei|Serizawa, Masakuni|Maruyama, Koji|Akiyama, Yasuto|Urakami, Kenichi|Kusuhara, Masatoshi|Moc
PMID: 28377632
Journal: Genes Chromosomes Cancer. 2017 Nov;56(11):769-787.
Title: The co-regulatory networks of tumor suppressor genes, oncogenes, and miRNAs in colorectal cancer.
Author: Slattery, Martha L|Herrick, Jennifer S|Mullany, Lila E|Samowitz, Wade S|Sevens, John R|Sakoda, Lori|Wolff, Roger K
PMID: 28675510
Journal: J Ethnopharmacol. 2017 Sep 14;209:305-316.
Title: Danshen improves survival of patients with colon cancer and dihydroisotanshinone I inhibit the proliferation of colon cancer cells via apoptosis and skp2 signaling pathway.
Author: Lin, Yin-Yin|Lee, I-Yun|Huang, Wen-Shih|Lin, Yu-Shin|Kuan, Feng-Che|Shu, Li-Hsin|Cheng, Yu-Ching|Yang, Yao-Hsu|Wu, Ching-Yuan
PMID: 28807849
Journal: J BUON. 2017 Sep-Oct;22(5):1122-1130.
Title: The prognostic role of Skp2 and the tumor suppressor protein p27 in colorectal cancer.
Author: Vasile Bochis, Ovidiu|Achimas-Cadariu, Patriciu|Vlad, Catalin|Fetica, Bogdan|Corneliu Leucuta, Daniel|Ioan Busuioc, Constantin|Irimie, Alexandru
PMID: 29135092
Journal: J Ethnopharmacol. 2018 Mar 1;213:446.
Title: Corrigendum to "Danshen improves survival of patients with colon cancer and dihydroisotanshinone I inhibit the proliferation of colon cancer cells via apoptosis and skp2 signaling pathway" [J. Ethnopharmacol. 209 (2017) 305-316].
Author: Lin, Yin-Yin|Lee, I-Yun|Huang, Wen-Shih|Lin, Yu-Shin|Kuan, Feng-Che|Shu, Li-Hsin|Cheng, Yu-Ching|Yang, Yao-Hsu|Wu, Ching-Yuan
PMID: 29150229
Journal: Oncogene. 2018 Mar;37(13):1759-1774.
Title: NDRG2 facilitates colorectal cancer differentiation through the regulation of Skp2-p21/p27 axis.
Author: Shen, Liangliang|Qu, Xuan|Li, Huichen|Xu, Chunsheng|Wei, Mengying|Wang, Qinhao|Ru, Yi|Liu, Bei|Xu, Yuqiao|Li, Kai|Hu, Junbi|Wang, Lifeng|Ma, Yongzheng|Li, Mengyang|Lai, Xiaofeng|Gao, Lei|Wu, Kaichun|Yao, Libo|Zheng, Jianyong|Zhang, Jian
PMID: 29343851
Journal: Mol Med Rep. 2018 Aug;18(2):1692-1703.
Title: Tanshinone IIA regulates colorectal cancer apoptosis via attenuation of Parkinmediated mitophagy by suppressing AMPK/Skp2 pathways.
Author: He, Lili|Gu, Kebo
PMID: 29845197
Journal: J Exp Clin Cancer Res. 2018 Aug 7;37(1):187.
Title: PCBP1 depletion promotes tumorigenesis through attenuation of p27(Kip1) mRNA stability and translation.
Author: Shi, Hongshun|Li, Hui|Yuan, Ronghua|Guan, Wen|Zhang, Xiaomei|Zhang, Shaoyang|Zhang, Wenliang|Tong, Fang|Li, Li|Song, Zhihong|Wang, Changwei|Yang, Shulan|Wang, Haihe
PMID: 30086790