Primary Site >> Colorectal Cancer
Gene >> SKP2
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Ref: Inverse relation between levels of p27(Kip1) and of its ubiquitin ligase subunit Skp2 in colorectal carcinomas. PMID: 11335900 |
Ref: Alterations in the expression of the cell cycle regulatory protein cyclin kinase subunit 1 in colorectal carcinoma. PMID: 15073847 Ref: Correlation of Skp2 with carcinogenesis, invasion, metastasis, and prognosis in colorectal tumors. PMID: 15201993 |
Ref: The prognostic impact of the ubiquitin ligase subunits Skp2 and Cks1 in colorectal carcinoma. PMID: 15717322 |
Ref: Prognostic role of p27Kip1 deregulation in colorectal cancer. PMID: 16826582 Ref: Testing the importance of p27 degradation by the SCFskp2 pathway in murine models of lung and colon cancer. PMID: 16966613 |
Ref: Gene expression profiles of primary colorectal carcinomas, liver metastases, and carcinomatoses. PMID: 17201907 Ref: High copy amplification of the Aurora-A gene is associated with chromosomal instability phenotype in human colorectal cancers. PMID: 17457043 |
Ref: p27 Kip1 nuclear localization and cyclin-dependent kinase inhibitory activity are regulated by glycogen synthase kinase-3 in human colon cancer cells. PMID: 18408738 Ref: Bortezomib (Velcade) induces p27Kip1 expression through S-phase kinase protein 2 degradation in colorectal cancer. PMID: 18451165 Ref: Regulation of Skp2-p27 axis by the Cdh1/anaphase-promoting complex pathway in colorectal tumorigenesis. PMID: 18535175 |
Ref: Tumor repressive functions of estrogen receptor beta in SW480 colon cancer cells. PMID: 19602591 |
Ref: Foxp3 expression in p53-dependent DNA damage responses. PMID: 20075077 Ref: STAT1 represses Skp2 gene transcription to promote p27Kip1 stabilization in Ras-transformed cells. PMID: 20407011 |
Ref: Modulation of liver X receptor signaling as a prevention and therapy for colon cancer. PMID: 21333456 |
Ref: Involvement of the SKP2-p27(KIP1) pathway in suppression of cancer cell proliferation by RECK. PMID: 22158033 |
Ref: The oxysterol receptors LXRalpha and LXRbeta suppress proliferation in the colon. PMID: 22610535 Ref: SKP2 overexpression is associated with a poor prognosis of rectal cancer treated with chemoradiotherapy and represents a therapeutic target with high potential. PMID: 23328995 Ref: Notch1-dependent regulation of p27 determines cell fate in colorectal cancer. PMID: 24141420 Ref: S-phase kinase-associated protein 2 knockdown blocks colorectal cancer growth via regulation of both p27 and p16 expression. PMID: 24336114 |
Ref: Interference of Skp2 effectively inhibits the development and metastasis of colon carcinoma. PMID: 24913024 Ref: The CREB-binding protein inhibitor ICG-001 suppresses pancreatic cancer growth. PMID: 25082960 |
Ref: Downregulation of thymidylate synthase and E2F1 by arsenic trioxide in mesothelioma. PMID: 25335113 Ref: Cks1 proteasomal degradation is induced by inhibiting Hsp90-mediated chaperoning in cancer cells. PMID: 25544127 Ref: microRNA-200b and microRNA-200c promote colorectal cancer cell proliferation via targeting the reversion-inducing cysteine-rich protein with Kazal motifs. PMID: 25826661 Ref: The role of Skp2 and its substrate CDKN1B (p27) in colorectal cancer. PMID: 26114183 Ref: Antitumor Activity of Americanin A Isolated from the Seeds of Phytolacca americana by Regulating the ATM/ATR Signaling Pathway and the Skp2-p27 Axis in Human Colon Cancer Cells. PMID: 26595875 |
Ref: Downregulated long non-coding RNA CLMAT3 promotes the proliferation of colorectal cancer cells by targeting regulators of the cell cycle pathway. PMID: 27391344 Ref: Copy number variation of E3 ubiquitin ligase genes in peripheral blood leukocyte and colorectal cancer. PMID: 27417709 |
Ref: Integrated analysis of gene expression and copy number identified potential cancer driver genes with amplification-dependent overexpression in 1,454 solid tumors. PMID: 28377632 Ref: The co-regulatory networks of tumor suppressor genes, oncogenes, and miRNAs in colorectal cancer. PMID: 28675510 Ref: Danshen improves survival of patients with colon cancer and dihydroisotanshinone I inhibit the proliferation of colon cancer cells via apoptosis and skp2 signaling pathway. PMID: 28807849 Ref: The prognostic role of Skp2 and the tumor suppressor protein p27 in colorectal cancer. PMID: 29135092 |
Ref: Corrigendum to "Danshen improves survival of patients with colon cancer and dihydroisotanshinone I inhibit the proliferation of colon cancer cells via apoptosis and skp2 signaling pathway" [J. Ethnopharmacol. 209 (2017) 305-316]. PMID: 29150229 Ref: NDRG2 facilitates colorectal cancer differentiation through the regulation of Skp2-p21/p27 axis. PMID: 29343851 Ref: Tanshinone IIA regulates colorectal cancer apoptosis via attenuation of Parkinmediated mitophagy by suppressing AMPK/Skp2 pathways. PMID: 29845197 Ref: PCBP1 depletion promotes tumorigenesis through attenuation of p27(Kip1) mRNA stability and translation. PMID: 30086790 |