Primary Site >> Colorectal Cancer

Gene >> SIRT2

Journal: J Am Chem Soc. 2009 May 27;131(20):6989-96.
Title: Inhibition of human sirtuins by in situ generation of an acetylated lysine-ADP-ribose conjugate.
Author: Asaba, Tomomi|Suzuki, Takayoshi|Ueda, Rie|Tsumoto, Hiroki|Nakagawa, Hidehiko|Miyata, Naoki
PMID: 19413317
Journal: Nat Cell Biol. 2010 Jul;12(7):665-75.
Title: Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity.
Author: Zhao, Ying|Yang, Jing|Liao, Wenjuan|Liu, Xiangyu|Zhang, Hui|Wang, Shan|Wang, Donglai|Feng, Jingnan|Yu, Li|Zhu, Wei-Guo
PMID: 20543840
Journal: J Med Chem. 2012 Jun 28;55(12):5760-73.
Title: Design, synthesis, and biological activity of a novel series of human sirtuin-2-selective inhibitors.
Author: Suzuki, Takayoshi|Khan, Mohammed Naseer Ahmed|Sawada, Hideyuki|Imai, Erika|Itoh, Yukihiro|Yamatsuta, Katsura|Tokuda, Natsuko|Takeuchi, Jun|Seko, Takuya|Nakagawa, Hidehiko|Miyata, Naoki
PMID: 22642300
Journal: J Med Chem. 2012 Dec 27;55(24):10937-47.
Title: Discovery of salermide-related sirtuin inhibitors: binding mode studies and antiproliferative effects in cancer cells including cancer stem cells.
Author: Rotili, Dante|Tarantino, Domenico|Nebbioso, Angela|Paolini, Chantal|Huidobro, Covadonga|Lara, Ester|Mellini, Paolo|Lenoci, Alessia|Pezzi, Riccardo|Botta, Giorgia|Lahtela-Kakkonen, Maija|Poso, Antti|Steinkuhler, Christian|Gallinari, Paola|De Maria, Ruggero
PMID: 23189967
Journal: Oncol Res. 2013;21(3):155-64.
Title: The sirtuin inhibitor tenovin-6 upregulates death receptor 5 and enhances cytotoxic effects of 5-fluorouracil and oxaliplatin in colon cancer cells.
Author: Ueno, Takunori|Endo, Shinji|Saito, Rie|Hirose, Mitsuaki|Hirai, Sachiko|Suzuki, Hideo|Yamato, Kenji|Hyodo, Ichinosuke
PMID: 24512730
Journal: Oncogene. 2015 Jan 22;34(4):531-6.
Title: A chromatin modifier genetic screen identifies SIRT2 as a modulator of response to targeted therapies through the regulation of MEK kinase activity.
Author: Bajpe, P K|Prahallad, A|Horlings, H|Nagtegaal, I|Beijersbergen, R|Bernards, R
PMID: 24469059
Journal: Cancer Lett. 2015 Jan 28;356(2 Pt B):637-45.
Title: AK-1, a specific SIRT2 inhibitor, induces cell cycle arrest by downregulating Snail in HCT116 human colon carcinoma cells.
Author: Cheon, Min Gyeong|Kim, Wootae|Choi, Minji|Kim, Ja-Eun
PMID: 25312940
Journal: Eur J Pharmacol. 2017 Feb 15;797:1-8.
Title: SIRT2 mediated antitumor effects of shikonin on metastatic colorectal cancer.
Author: Zhang, Li-Li|Zhan, Lin|Jin, Yong-Dong|Min, Zhen-Li|Wei, Can|Wang, Qiang|Chen, Ya-Jun|Wu, Qing-Ming|Hu, Xia-Min|Yuan, Qiong
PMID: 28088387
Journal: Oncotarget. 2017 Jun 20;8(25):41021-41025.
Title: A variant in SIRT2 gene 3'-UTR is associated with susceptibility to colorectal cancer.
Author: Yang, Yong|Ding, Jie|Gao, Zhi-Gang|Wang, Zhen-Jun
PMID: 28514749