Primary Site >> Colorectal Cancer
Gene >> SIRT2
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Ref: Inhibition of human sirtuins by in situ generation of an acetylated lysine-ADP-ribose conjugate. PMID: 19413317 |
Ref: Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity. PMID: 20543840 |
Ref: Design, synthesis, and biological activity of a novel series of human sirtuin-2-selective inhibitors. PMID: 22642300 Ref: Discovery of salermide-related sirtuin inhibitors: binding mode studies and antiproliferative effects in cancer cells including cancer stem cells. PMID: 23189967 |
Ref: The sirtuin inhibitor tenovin-6 upregulates death receptor 5 and enhances cytotoxic effects of 5-fluorouracil and oxaliplatin in colon cancer cells. PMID: 24512730 |
Ref: A chromatin modifier genetic screen identifies SIRT2 as a modulator of response to targeted therapies through the regulation of MEK kinase activity. PMID: 24469059 Ref: AK-1, a specific SIRT2 inhibitor, induces cell cycle arrest by downregulating Snail in HCT116 human colon carcinoma cells. PMID: 25312940 |
Ref: SIRT2 mediated antitumor effects of shikonin on metastatic colorectal cancer. PMID: 28088387 Ref: A variant in SIRT2 gene 3'-UTR is associated with susceptibility to colorectal cancer. PMID: 28514749 |