Primary Site >> Liver Cancer
Gene >> SHH
| 1. | |||||||||||
| Journal: | BMC Cancer. 2004 Aug 4;4:43. | ||||||||||
| Title: | Hedgehog-interacting protein is highly expressed in endothelial cells but down-regulated during angiogenesis and in several human tumors. | ||||||||||
| Author: | Olsen, Catherine L|Hsu, Pin-Pin|Glienke, Jens|Rubanyi, Gabor M|Brooks, Alan R | ||||||||||
| PMID: | 15294024 | ||||||||||
| 2. | |||||||||||
| Journal: | Carcinogenesis. 2006 Jul;27(7):1334-40. | ||||||||||
| Title: | Activation of the hedgehog pathway in human hepatocellular carcinomas. | ||||||||||
| Author: | Huang, Shuhong|He, Jing|Zhang, Xiaoli|Bian, Yuehong|Yang, Ling|Xie, Guorui|Zhang, Kefei|Tang, Wendell|Stelter, Arwen A|Wang, Qian|Zhang, Hongwei|Xie, Jingwu | ||||||||||
| PMID: | 16501253 | ||||||||||
| 3. | |||||||||||
| Journal: | Acta Biochim Biophys Sin (Shanghai). 2008 Sep;40(9):819-29. | ||||||||||
| Title: | Down-regulation of Sonic hedgehog signaling pathway activity is involved in 5-fluorouracil-induced apoptosis and motility inhibition in Hep3B cells. | ||||||||||
| Author: | Wang, Qiyu|Huang, Shuhong|Yang, Ling|Zhao, Ling|Yin, Yuxia|Liu, Zhongzhen|Chen, Zheyu|Zhang, Hongwei | ||||||||||
| PMID: | 18776995 | ||||||||||
| 4. | |||||||||||
| Journal: | Beijing Da Xue Xue Bao Yi Xue Ban. 2008 Dec 18;40(6):616-23. | ||||||||||
| Title: | [Expression of genes related to Sonic Hedgehog signaling in human hepatocellular carcinomas]. | ||||||||||
| Author: | Che, Li|Ren, Jun|Yuan, Yan Hua|Jia, Jun|Di, Li Jun|Song, Guo Hong|Yu, Jing|Wang, Xiao Li | ||||||||||
| PMID: | 19088834 | ||||||||||
| 5. | |||||||||||
| Journal: | Int J Oncol. 2009 Mar;34(3):829-36. | ||||||||||
| Title: | Role of Hedgehog signaling pathway in proliferation and invasiveness of hepatocellular carcinoma cells. | ||||||||||
| Author: | Cheng, Wei-Ting|Xu, Kai|Tian, De-Ying|Zhang, Zheng-Gang|Liu, Li-Jiang|Chen, Ying | ||||||||||
| PMID: | 19212688 | ||||||||||
| 6. | |||||||||||
| Journal: | Int J Oncol. 2009 Jul;35(1):69-80. | ||||||||||
| Title: | Cellular plasticity of trans- and dedifferentiation markers in human hepatoma cells in vitro and in vivo. | ||||||||||
| Author: | Jabari, Samir|Meissnitzer, Matthias|Quint, Karl|Gahr, Susanne|Wissniowski, Till|Hahn, Eckhart G|Neureiter, Daniel|Ocker, Matthias | ||||||||||
| PMID: | 19513553 | ||||||||||
| 7. | |||||||||||
| Journal: | Arch Med Res. 2010 Jul;41(5):315-23. | ||||||||||
| Title: | Expression of sonic hedgehog signaling components in hepatocellular carcinoma and cyclopamine-induced apoptosis through Bcl-2 downregulation in vitro. | ||||||||||
| Author: | Chen, Xi-lin|Cheng, Quan-yong|She, Miao-rong|Wang, Qian|Huang, Xiao-hui|Cao, Liang-qi|Fu, Xin-hui|Chen, Jing-song | ||||||||||
| PMID: | 20851287 | ||||||||||
| 8. | |||||||||||
| Journal: | Mol Med Rep. 2010 Nov-Dec;3(6):965-70. | ||||||||||
| Title: | Evaluation of glioma-associated oncogene 1 expression and its correlation with the expression of sonic hedgehog, E-cadherin and S100a4 in human hepatocellular carcinoma. | ||||||||||
| Author: | Zheng, Xin|Yao, Yingmin|Xu, Qiuran|Tu, Kangsheng|Liu, Qingguang | ||||||||||
| PMID: | 21472341 | ||||||||||
| 9. | |||||||||||
| Journal: | Int J Radiat Oncol Biol Phys. 2011 Jul 1;80(3):851-9. | ||||||||||
| Title: | Sonic hedgehog signaling protects human hepatocellular carcinoma cells against ionizing radiation in an autocrine manner. | ||||||||||
| Author: | Chen, Yu-Jen|Lin, Chin-Ping|Hsu, Ming-Ling|Shieh, Hui-Ru|Chao, Nicholas K|Chao, K S Clifford | ||||||||||
| PMID: | 21377281 | ||||||||||
| 10. | |||||||||||
| Journal: | ANZ J Surg. 2011 Jun;81(6):440-5. | ||||||||||
| Title: | The Hedgehog signalling pathway and its prognostic impact in human gliomas. | ||||||||||
| Author: | Li, Qiaoyu|Zhang, Yan|Zhan, Hongfeng|Yuan, Zhicheng|Lu, Peisong|Zhan, Liping|Xu, Wenlin | ||||||||||
| PMID: | 22295347 | ||||||||||
| 11. | |||||||||||
| Journal: | Acta Pharmacol Sin. 2012 May;33(5):691-700. | ||||||||||
| Title: | Hedgehog signaling pathway mediates invasion and metastasis of hepatocellular carcinoma via ERK pathway. | ||||||||||
| Author: | Lu, Jing-tao|Zhao, Wen-di|He, Wei|Wei, Wei | ||||||||||
| PMID: | 22543708 | ||||||||||
| 12. | |||||||||||
| Journal: | Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2012 May;28(5):536-9. | ||||||||||
| Title: | [Gli1 expression and its relationship with the expression of Shh, Vimentin and E-cadherin in human hepatocellular carcinoma]. | ||||||||||
| Author: | Xu, Qiu-ran|Zheng, Xin|Zan, Xian-feng|Yao, Ying-min|Yang, Wei|Liu, Qing-guang | ||||||||||
| PMID: | 22558994 | ||||||||||
| 13. | |||||||||||
| Journal: | Oncol Lett. 2012 Dec;4(6):1158-1162. | ||||||||||
| Title: | Blockade of the sonic hedgehog pathway effectively inhibits the growth of hepatoma in mice: An in vivo study. | ||||||||||
| Author: | Jeng, Kuo-Shyang|Sheen, I-Shyan|Jeng, Wen-Juei|Yu, Ming-Che|Tsai, Hsin-Hua|Chang, Fang-Yu|Su, Jui-Chih | ||||||||||
| PMID: | 23205113 | ||||||||||
| 14. | |||||||||||
| Journal: | Chin J Cancer Res. 2012 Dec;24(4):323-31. | ||||||||||
| Title: | Activation of sonic hedgehog signaling pathway is an independent potential prognosis predictor in human hepatocellular carcinoma patients. | ||||||||||
| Author: | Che, Li|Yuan, Yan-Hua|Jia, Jun|Ren, Jun | ||||||||||
| PMID: | 23359030 | ||||||||||
| 15. | |||||||||||
| Journal: | IET Syst Biol. 2013 Dec;7(6):243-51. | ||||||||||
| Title: | Systems analysis utilising pathway interactions identifies sonic hedgehog pathway as a primary biomarker and oncogenic target in hepatocellular carcinoma. | ||||||||||
| Author: | Efroni, Sol|Meerzaman, Daoud|Schaefer, Carl F|Greenblum, Sharon|Soo-Lyu, Myung|Hu, Ying|Cultraro, Constance|Meshorer, Eran|Buetow, Kenneth H | ||||||||||
| PMID: | 24712101 | ||||||||||
| 16. | |||||||||||
| Journal: | Onco Targets Ther. 2013 Aug 5;6:1047-55. | ||||||||||
| Title: | Activation of the sonic hedgehog signaling pathway occurs in the CD133 positive cells of mouse liver cancer Hepa 1-6 cells. | ||||||||||
| Author: | Jeng, Kuo-Shyang|Sheen, I-Shyan|Jeng, Wen-Juei|Yu, Ming-Che|Hsiau, Hsin-I|Chang, Fang-Yu|Tsai, Hsin-Hua | ||||||||||
| PMID: | 23950652 | ||||||||||
| 17. | |||||||||||
| Journal: | Hepatology. 2013 Sep;58(3):995-1010. | ||||||||||
| Title: | Hedgehog signaling pathway regulates autophagy in human hepatocellular carcinoma cells. | ||||||||||
| Author: | Wang, Ying|Han, Chang|Lu, Lu|Magliato, Susan|Wu, Tong | ||||||||||
| PMID: | 23504944 | ||||||||||
| 18. | |||||||||||
| Journal: | Carcinogenesis. 2013 Jan;34(1):10-9. | ||||||||||
| Title: | Sonic hedgehog signaling pathway induces cell migration and invasion through focal adhesion kinase/AKT signaling-mediated activation of matrix metalloproteinase (MMP)-2 and MMP-9 in liver cancer. | ||||||||||
| Author: | Chen, Jing-Song|Huang, Xiao-hui|Wang, Qian|Huang, Jiong-Qiang|Zhang, Long-juan|Chen, Xi-Lin|Lei, Jian|Cheng, Zhi-Xiang | ||||||||||
| PMID: | 22948179 | ||||||||||
| 19. | |||||||||||
| Journal: | Ann Surg Oncol. 2013 Feb;20(2):464-73. | ||||||||||
| Title: | High expression of patched homolog-1 messenger RNA and glioma-associated oncogene-1 messenger RNA of sonic hedgehog signaling pathway indicates a risk of postresection recurrence of hepatocellular carcinoma. | ||||||||||
| Author: | Jeng, Kuo-Shyang|Sheen, I-Shyan|Jeng, Wen-Juei|Lin, Chien-Chu|Lin, Chien-Kuan|Su, Jui-Chih|Yu, Ming-Che|Fang, Hsin-Yi | ||||||||||
| PMID: | 22911366 | ||||||||||
| 20. | |||||||||||
| Journal: | Oncol Lett. 2013 Jan;5(1):127-134. | ||||||||||
| Title: | The pan-deacetylase inhibitor panobinostat modulates the expression of epithelial-mesenchymal transition markers in hepatocellular carcinoma models. | ||||||||||
| Author: | DI Fazio, Pietro|Montalbano, Roberta|Quint, Karl|Alinger, Beate|Kemmerling, Ralf|Kiesslich, Tobias|Ocker, Matthias|Neureiter, Daniel | ||||||||||
| PMID: | 23255907 | ||||||||||
| 21. | |||||||||||
| Journal: | Cancer Res. 2014 Nov 1;74(21):5963-77. | ||||||||||
| Title: | Network modeling of TGFbeta signaling in hepatocellular carcinoma epithelial-to-mesenchymal transition reveals joint sonic hedgehog and Wnt pathway activation. | ||||||||||
| Author: | Steinway, Steven Nathaniel|Zanudo, Jorge G T|Ding, Wei|Rountree, Carl Bart|Feith, David J|Loughran, Thomas P Jr|Albert, Reka | ||||||||||
| PMID: | 25189528 | ||||||||||
| 22. | |||||||||||
| Journal: | Oncol Lett. 2015 Oct;10(4):2227-2232. | ||||||||||
| Title: | BRD4 induces cell migration and invasion in HCC cells through MMP-2 and MMP-9 activation mediated by the Sonic hedgehog signaling pathway. | ||||||||||
| Author: | Wang, Yong-Hui|Sui, Xiao-Mei|Sui, Ya-Na|Zhu, Qin-Wei|Yan, Kai|Wang, Li-Shan|Wang, Fei|Zhou, Jia-Hua | ||||||||||
| PMID: | 26622824 | ||||||||||
| 23. | |||||||||||
| Journal: | Cell Mol Biol (Noisy-le-grand). 2015 Oct 30;61(6):85-91. | ||||||||||
| Title: | Saturated fatty acid induces cancer stem cell-like properties in human hepatoma cells. | ||||||||||
| Author: | Chong, L-W|Chou, R-H|Liao, C-C|Lee, T-F|Lin, Y|Yang, K-C|Hsu, Y-C | ||||||||||
| PMID: | 26518899 | ||||||||||
| 24. | |||||||||||
| Journal: | Toxicol Appl Pharmacol. 2015 Oct 1;288(1):74-83. | ||||||||||
| Title: | Melittin induces PTCH1 expression by down-regulating MeCP2 in human hepatocellular carcinoma SMMC-7721 cells. | ||||||||||
| Author: | Wu, Xiaoqin|Zhao, Bin|Cheng, Yahui|Yang, Yang|Huang, Cheng|Meng, Xiaoming|Wu, Baoming|Zhang, Lei|Lv, Xiongwen|Li, Jun | ||||||||||
| PMID: | 26189965 | ||||||||||
| 25. | |||||||||||
| Journal: | Am J Surg. 2015 Sep;210(3):554-60. | ||||||||||
| Title: | Sonic hedgehog pathway inhibitor mitigates mouse hepatocellular carcinoma. | ||||||||||
| Author: | Jeng, Kuo-Shyang|Jeng, Chi-Juei|Jeng, Wen-Juei|Sheen, I-Shyan|Chang, Chiung-Fang|Hsiau, Hsin-I|Hung, Zih-Hang|Yu, Ming-Che|Chang, Fang-Yu | ||||||||||
| PMID: | 26073903 | ||||||||||
| 26. | |||||||||||
| Journal: | Integr Cancer Ther. 2015 Jul;14(4):394-401. | ||||||||||
| Title: | Inhibition of Hepatocellular Carcinoma by Total Alkaloids of Rubus alceifolius Poir Involves Suppression of Hedgehog Signaling. | ||||||||||
| Author: | Zhao, Jinyan|Liu, Liya|Wan, Yun|Zhang, Yuchen|Zhuang, Qunchuan|Zhong, Xiaoyong|Hong, Zhenfeng|Peng, Jun | ||||||||||
| PMID: | 25917815 | ||||||||||
| 27. | |||||||||||
| Journal: | Pathol Oncol Res. 2015 Sep;21(4):901-8. | ||||||||||
| Title: | Differential Expression of Sonic Hedgehog Protein in Human Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma. | ||||||||||
| Author: | Al-Bahrani, Redha|Nagamori, Seishi|Leng, Roger|Petryk, Anna|Sergi, Consolato | ||||||||||
| PMID: | 25740074 | ||||||||||
| 28. | |||||||||||
| Journal: | J Gastroenterol Hepatol. 2015 Aug;30(8):1317-24. | ||||||||||
| Title: | Sonic Hedgehog inhibition as a strategy to augment radiosensitivity of hepatocellular carcinoma. | ||||||||||
| Author: | Tsai, Chiao-Ling|Hsu, Feng-Ming|Tzen, Kai-Yuan|Liu, Wei-Lin|Cheng, Ann-Lii|Cheng, Jason Chia-Hsien | ||||||||||
| PMID: | 25682950 | ||||||||||
| 29. | |||||||||||
| Journal: | Tumour Biol. 2016 Jan;37(1):877-85. | ||||||||||
| Title: | Genome-wide profiling of DNA methylation reveals preferred sequences of DNMTs in hepatocellular carcinoma cells. | ||||||||||
| Author: | Fan, Hong|Zhao, Zhujiang|Cheng, Yuchao|Cui, He|Qiao, Fengchang|Wang, Ling|Hu, Jiaojiao|Wu, Huzhang|Song, Wei | ||||||||||
| PMID: | 26254611 | ||||||||||
| 30. | |||||||||||
| Journal: | J Hepatol. 2016 Mar;64(3):618-27. | ||||||||||
| Title: | Hepatic expression of Sonic Hedgehog induces liver fibrosis and promotes hepatocarcinogenesis in a transgenic mouse model. | ||||||||||
| Author: | Chung, Sook In|Moon, Hyuk|Ju, Hye-Lim|Cho, Kyung Joo|Kim, Do Young|Han, Kwang-Hyub|Eun, Jung Woo|Nam, Suk Woo|Ribback, Silvia|Dombrowski, Frank|Calvisi, Diego F|Ro, Simon Weonsang | ||||||||||
| PMID: | 26471504 | ||||||||||
| 31. | |||||||||||
| Journal: | Mol Clin Oncol. 2016 Mar;4(3):369-374. | ||||||||||
| Title: | Sonic hedgehog signaling in hepatocellular carcinoma: A pilot study. | ||||||||||
| Author: | Dugum, Mohannad|Hanouneh, Ibrahim|McIntyre, Thomas|Pai, Rish|Aucejo, Federico|Eghtesad, Bijan|Zein, Nizar | ||||||||||
| PMID: | 26998285 | ||||||||||
| 32. | |||||||||||
| Journal: | Histochem Cell Biol. 2016 Jul;146(1):85-97. | ||||||||||
| Title: | SULF1/SULF2 reactivation during liver damage and tumour growth. | ||||||||||
| Author: | Graham, Kurtis|Murphy, Joshua I|Dhoot, Gurtej K | ||||||||||
| PMID: | 27013228 | ||||||||||
| 33. | |||||||||||
| Journal: | J Cancer. 2016 Jun 6;7(9):1142-51. | ||||||||||
| Title: | Liver Label Retaining Cancer Cells Are Relatively Resistant to the Reported Anti-Cancer Stem Cell Drug Metformin. | ||||||||||
| Author: | Xin, Hong-Wu|Ambe, Chenwi M|Miller, Tyler C|Chen, Jin-Qiu|Wiegand, Gordon W|Anderson, Andrew J|Ray, Satyajit|Mullinax, John E|Hari, Danielle M|Koizumi, Tomotake|Godbout, Jessica D|Goldsmith, Paul K|Stojadinovic, Alexander|Rudloff, Udo|Thorgeirsson, Snorri | ||||||||||
| PMID: | 27326258 | ||||||||||
| 34. | |||||||||||
| Journal: | Histopathology. 2016 Dec;69(6):971-984. | ||||||||||
| Title: | Steatotic hepatocellular carcinoma: a variant associated with metabolic factors and late tumour relapse. | ||||||||||
| Author: | Chan, Anthony W H|Yu, Shuangni|Yu, Yau-Hei|Tong, Joanna H M|Wang, Lei|Tin, Edith K Y|Chong, Charing C N|Chan, Stephen L|Wong, Grace L H|Wong, Vincent W S|Chan, Henry L Y|Lai, Paul B S|To, Ka-Fai | ||||||||||
| PMID: | 27380543 | ||||||||||
| 35. | |||||||||||
| Journal: | Tumour Biol. 2016 Oct 15. pii: 10.1007/s13277-016-5463-6. | ||||||||||
| Title: | Sonic hedgehog signaling pathway mediates development of hepatocellular carcinoma. | ||||||||||
| Author: | Cai, Heng|Li, Hongxing|Li, Jingmin|Li, Xiaoyan|Li, Yana|Shi, Yan|Wang, Dong | ||||||||||
| PMID: | 27744627 | ||||||||||
| 36. | |||||||||||
| Journal: | Cell Physiol Biochem. 2017;44(5):1856-1868. | ||||||||||
| Title: | Hypoxia Accelerates Aggressiveness of Hepatocellular Carcinoma Cells Involving Oxidative Stress, Epithelial-Mesenchymal Transition and Non-Canonical Hedgehog Signaling. | ||||||||||
| Author: | Liu, Zhikui|Tu, Kangsheng|Wang, Yufeng|Yao, Bowen|Li, Qing|Wang, Liang|Dou, Changwei|Liu, Qingguang|Zheng, Xin | ||||||||||
| PMID: | 29237157 | ||||||||||
| 37. | |||||||||||
| Journal: | Sci Rep. 2018 Jan 15;8(1):731. | ||||||||||
| Title: | Hyaluronic acid-based nano-sized drug carrier-containing Gellan gum microspheres as potential multifunctional embolic agent. | ||||||||||
| Author: | Hsu, Ming Fang|Tyan, Yen Sheng|Chien, Yu Chen|Lee, Ming Wei | ||||||||||
| PMID: | 29335649 | ||||||||||
| 38. | |||||||||||
| Journal: | J Cell Mol Med. 2018 Jul;22(7):3679-3690. | ||||||||||
| Title: | The SHH/Gli axis regulates CD90-mediated liver cancer stem cell function by activating the IL6/JAK2 pathway. | ||||||||||
| Author: | Zhang, Ketao|Che, Siyao|Pan, Chuzhi|Su, Zheng|Zheng, Shangyou|Yang, Shanglin|Zhang, Huayao|Li, Wenda|Wang, Weidong|Liu, Jianping | ||||||||||
| PMID: | 29722127 | ||||||||||