Primary Site >> Liver Cancer
Gene >> SHH
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Ref: Hedgehog-interacting protein is highly expressed in endothelial cells but down-regulated during angiogenesis and in several human tumors. PMID: 15294024 |
Ref: Activation of the hedgehog pathway in human hepatocellular carcinomas. PMID: 16501253 |
Ref: Down-regulation of Sonic hedgehog signaling pathway activity is involved in 5-fluorouracil-induced apoptosis and motility inhibition in Hep3B cells. PMID: 18776995 Ref: [Expression of genes related to Sonic Hedgehog signaling in human hepatocellular carcinomas]. PMID: 19088834 |
Ref: Role of Hedgehog signaling pathway in proliferation and invasiveness of hepatocellular carcinoma cells. PMID: 19212688 Ref: Cellular plasticity of trans- and dedifferentiation markers in human hepatoma cells in vitro and in vivo. PMID: 19513553 |
Ref: Expression of sonic hedgehog signaling components in hepatocellular carcinoma and cyclopamine-induced apoptosis through Bcl-2 downregulation in vitro. PMID: 20851287 Ref: Evaluation of glioma-associated oncogene 1 expression and its correlation with the expression of sonic hedgehog, E-cadherin and S100a4 in human hepatocellular carcinoma. PMID: 21472341 |
Ref: Sonic hedgehog signaling protects human hepatocellular carcinoma cells against ionizing radiation in an autocrine manner. PMID: 21377281 Ref: The Hedgehog signalling pathway and its prognostic impact in human gliomas. PMID: 22295347 |
Ref: Hedgehog signaling pathway mediates invasion and metastasis of hepatocellular carcinoma via ERK pathway. PMID: 22543708 Ref: [Gli1 expression and its relationship with the expression of Shh, Vimentin and E-cadherin in human hepatocellular carcinoma]. PMID: 22558994 Ref: Blockade of the sonic hedgehog pathway effectively inhibits the growth of hepatoma in mice: An in vivo study. PMID: 23205113 Ref: Activation of sonic hedgehog signaling pathway is an independent potential prognosis predictor in human hepatocellular carcinoma patients. PMID: 23359030 |
Ref: High expression of patched homolog-1 messenger RNA and glioma-associated oncogene-1 messenger RNA of sonic hedgehog signaling pathway indicates a risk of postresection recurrence of hepatocellular carcinoma. PMID: 22911366 Ref: Sonic hedgehog signaling pathway induces cell migration and invasion through focal adhesion kinase/AKT signaling-mediated activation of matrix metalloproteinase (MMP)-2 and MMP-9 in liver cancer. PMID: 22948179 Ref: The pan-deacetylase inhibitor panobinostat modulates the expression of epithelial-mesenchymal transition markers in hepatocellular carcinoma models. PMID: 23255907 Ref: Hedgehog signaling pathway regulates autophagy in human hepatocellular carcinoma cells. PMID: 23504944 Ref: Activation of the sonic hedgehog signaling pathway occurs in the CD133 positive cells of mouse liver cancer Hepa 1-6 cells. PMID: 23950652 Ref: Systems analysis utilising pathway interactions identifies sonic hedgehog pathway as a primary biomarker and oncogenic target in hepatocellular carcinoma. PMID: 24712101 |
Ref: Network modeling of TGFbeta signaling in hepatocellular carcinoma epithelial-to-mesenchymal transition reveals joint sonic hedgehog and Wnt pathway activation. PMID: 25189528 |
Ref: Sonic Hedgehog inhibition as a strategy to augment radiosensitivity of hepatocellular carcinoma. PMID: 25682950 Ref: Differential Expression of Sonic Hedgehog Protein in Human Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma. PMID: 25740074 Ref: Inhibition of Hepatocellular Carcinoma by Total Alkaloids of Rubus alceifolius Poir Involves Suppression of Hedgehog Signaling. PMID: 25917815 Ref: Sonic hedgehog pathway inhibitor mitigates mouse hepatocellular carcinoma. PMID: 26073903 Ref: Melittin induces PTCH1 expression by down-regulating MeCP2 in human hepatocellular carcinoma SMMC-7721 cells. PMID: 26189965 Ref: Saturated fatty acid induces cancer stem cell-like properties in human hepatoma cells. PMID: 26518899 Ref: BRD4 induces cell migration and invasion in HCC cells through MMP-2 and MMP-9 activation mediated by the Sonic hedgehog signaling pathway. PMID: 26622824 |
Ref: Genome-wide profiling of DNA methylation reveals preferred sequences of DNMTs in hepatocellular carcinoma cells. PMID: 26254611 Ref: Hepatic expression of Sonic Hedgehog induces liver fibrosis and promotes hepatocarcinogenesis in a transgenic mouse model. PMID: 26471504 Ref: Sonic hedgehog signaling in hepatocellular carcinoma: A pilot study. PMID: 26998285 Ref: SULF1/SULF2 reactivation during liver damage and tumour growth. PMID: 27013228 Ref: Liver Label Retaining Cancer Cells Are Relatively Resistant to the Reported Anti-Cancer Stem Cell Drug Metformin. PMID: 27326258 Ref: Steatotic hepatocellular carcinoma: a variant associated with metabolic factors and late tumour relapse. PMID: 27380543 Ref: Sonic hedgehog signaling pathway mediates development of hepatocellular carcinoma. PMID: 27744627 |
Ref: Hypoxia Accelerates Aggressiveness of Hepatocellular Carcinoma Cells Involving Oxidative Stress, Epithelial-Mesenchymal Transition and Non-Canonical Hedgehog Signaling. PMID: 29237157 |
Ref: Hyaluronic acid-based nano-sized drug carrier-containing Gellan gum microspheres as potential multifunctional embolic agent. PMID: 29335649 Ref: The SHH/Gli axis regulates CD90-mediated liver cancer stem cell function by activating the IL6/JAK2 pathway. PMID: 29722127 |