Primary Site >> Colorectal Cancer

Gene >> SHH

Journal: Eur J Cancer. 1999 May;35(5):711-3.
Title: The patched/hedgehog/smoothened signalling pathway in human breast cancer: no evidence for H133Y SHH, PTCH and SMO mutations.
Author: Vorechovsky, I|Benediktsson, K P|Toftgard, R
PMID: 10505029
Journal: Oncogene. 2004 Jun 3;23(26):4577-83.
Title: Failure of a medulloblastoma-derived mutant of SUFU to suppress WNT signaling.
Author: Taylor, Michael D|Zhang, Xiaoyun|Liu, Ling|Hui, Chi-Chung|Mainprize, Todd G|Scherer, Stephen W|Wainwright, Brandon|Hogg, David|Rutka, James T
PMID: 15077159
Journal: J Pathol. 2004 Aug;203(4):909-17.
Title: Expression of Sonic hedgehog pathway genes is altered in colonic neoplasia.
Author: Oniscu, Anca|James, Roberta M|Morris, Robert G|Bader, Scott|Malcomson, Roger D G|Harrison, David J
PMID: 15258993
Journal: Int J Oncol. 2005 Feb;26(2):545-9.
Title: Identification and characterization of rat Desert hedgehog and Indian hedgehog genes in silico.
Author: Katoh, Yuriko|Katoh, Masaru
PMID: 15645142
Journal: Oncol Rep. 2005 Oct;14(4):1087-90.
Title: Comparative genomics on Sonic hedgehog orthologs.
Author: Katoh, Yuriko|Katoh, Masaru
PMID: 16142377
Journal: Cancer Lett. 2006 Feb 20;233(1):117-23.
Title: Sonic hedgehog mRNA expression by real-time quantitative PCR in normal and tumor tissues from colorectal cancer patients.
Author: Monzo, Mariano|Moreno, Isabel|Artells, Rosa|Ibeas, Rafael|Navarro, Alfons|Moreno, Jose|Hernandez, Raquel|Granell, Miquel|Pie, Jordi
PMID: 16473672
Journal: Surgery. 2006 May;139(5):665-70.
Title: Sonic Hedgehog-dependent proliferation in a series of patients with colorectal cancer.
Author: Douard, Richard|Moutereau, Stephane|Pernet, Pascal|Chimingqi, Mihelaiti|Allory, Yves|Manivet, Philippe|Conti, Marc|Vaubourdolle, Michel|Cugnenc, Paul-Henri|Loric, Sylvain
PMID: 16701100
Journal: Int J Mol Med. 2006 Dec;18(6):1019-23.
Title: Hedgehog signaling pathway and gastrointestinal stem cell signaling network (review).
Author: Katoh, Yuriko|Katoh, Masaru
PMID: 17089004
Journal: World J Gastroenterol. 2007 Mar 21;13(11):1659-65.
Title: Sonic hedgehog-Gli1 pathway in colorectal adenocarcinomas.
Author: Bian, Yue-Hong|Huang, Shu-Hong|Yang, Ling|Ma, Xiao-Li|Xie, Jing-Wu|Zhang, Hong-Wei
PMID: 17461467
Journal: In Vitro Cell Dev Biol Anim. 2007 Mar-Apr;43(3-4):105-8.
Title: Isolation and characterization of two novel colon cancer cell lines from Chinese patients.
Author: Hu, Dan-Ning|Hwang, Shiaw-Min|Lin, Xi-Zhang|Yang, Pei-Yuh|Tsai, Chi-Hong|Huang, Qiang|Huang, Hsin-Yi|Hwang, Min-Huo
PMID: 17554590
Journal: Int J Cancer. 2007 Dec 15;121(12):2622-7.
Title: Hedgehog signaling pathway is inactive in colorectal cancer cell lines.
Author: Chatel, Guillaume|Ganeff, Corine|Boussif, Naima|Delacroix, Laurence|Briquet, Alexandra|Nolens, Gregory|Winkler, Rosita
PMID: 17683069
Journal: J Pathol. 2007 Oct;213(2):131-9.
Title: Transcriptional silencing of hedgehog-interacting protein by CpG hypermethylation and chromatic structure in human gastrointestinal cancer.
Author: Taniguchi, H|Yamamoto, H|Akutsu, N|Nosho, K|Adachi, Y|Imai, K|Shinomura, Y
PMID: 17724792
Journal: Virchows Arch. 2009 Apr;454(4):369-79.
Title: Hedgehog signaling is involved in differentiation of normal colonic tissue rather than in tumor proliferation.
Author: Alinger, Beate|Kiesslich, Tobias|Datz, Christian|Aberger, Fritz|Strasser, Felix|Berr, Frieder|Dietze, Otto|Kaserer, Klaus|Hauser-Kronberger, Cornelia
PMID: 19280222
Journal: J Gastroenterol. 2009;44(11):1113-7.
Title: Sonic hedgehog relates to colorectal carcinogenesis.
Author: Yoshikawa, Kozo|Shimada, Mitsuo|Miyamoto, Hidenori|Higashijima, Jun|Miyatani, Tomohiko|Nishioka, Masanori|Kurita, Nobuhiro|Iwata, Takashi|Uehara, Hisanori
PMID: 19662327
Journal: Mol Cell Biochem. 2010 Apr;337(1-2):185-92.
Title: Distinct expression patterns of hedgehog ligands between cultured and primary colorectal cancers are associated with aberrant methylation of their promoters.
Author: Fu, Xiangsheng|Deng, Hong|Zhao, Luping|Li, Jing|Zhou, Yongbai|Zhang, Yali
PMID: 19856079
Journal: Ups J Med Sci. 2010 Aug;115(3):169-75.
Title: PTCH1, a receptor of Hedgehog signaling pathway, is correlated with metastatic potential of colorectal cancer.
Author: You, Sihong|Zhou, Jiannong|Chen, Senqing|Zhou, Ping|Lv, Jinghuan|Han, Xiao|Sun, Yujie
PMID: 20230186
Journal: Mech Dev. 2010 Jan-Feb;127(1-2):73-81.
Title: Hedgehog pathway activity is required for the lethality and intestinal phenotypes of mice with hyperactive Wnt signaling.
Author: Varnat, Frederic|Zacchetti, Giovanna|Ruiz i Altaba, Ariel
PMID: 19861162
Journal: Mol Med Rep. 2011 Sep-Oct;4(5):873-7.
Title: Differential expression profiles of the Hedgehog signaling pathway between microsatellite-stable and microsatellite-unstable colorectal cancers.
Author: Hu, Xuguang|Lai, Daili|Chen, Wei|Zi, Shuming|Li, Jinming|Du, Peng|Wang, Zhongchuan|Huang, Shiyong|Long, Cui
PMID: 21725600
Journal: Chin Med. 2011 Aug 23;6:31.
Title: Potential applications of curcumin and its novel synthetic analogs and nanotechnology-based formulations in cancer prevention and therapy.
Author: Mimeault, Murielle|Batra, Surinder K
PMID: 21859497
Journal: Hepatogastroenterology. 2011 Sep-Oct;58(110-111):1511-8.
Title: Cyclopamine blocked the growth of colorectal cancer SW116 cells by modulating some target genes of Gli1 in vitro.
Author: Wu, Jian-Ye|Xu, Xuan-Fu|Xu, Ling|Niu, Pei-Qin|Wang, Feng|Hu, Guo-Yong|Wang, Xing-Peng|Guo, Chuan-Yong
PMID: 21940310
Journal: Int J Cancer. 2012 Mar 1;130(5):1082-92.
Title: A distinct DNA methylation profile associated with microsatellite and chromosomal stable sporadic colorectal cancers.
Author: Silver, Andrew|Sengupta, Neel|Propper, David|Wilson, Peter|Hagemann, Thorsten|Patel, Asif|Parker, Alexandra|Ghosh, Anil|Feakins, Roger|Dorudi, Sina|Suraweera, Nirosha
PMID: 21455990
Journal: Exp Cell Res. 2012 Mar 10;318(5):539-49.
Title: Abrogation of Gli3 expression suppresses the growth of colon cancer cells via activation of p53.
Author: Kang, Han Na|Oh, Sang Cheul|Kim, Jun Suk|Yoo, Young A
PMID: 22227409
Journal: Carcinogenesis. 2012 Jun;33(6):1158-68.
Title: Folate deprivation enhances invasiveness of human colon cancer cells mediated by activation of sonic hedgehog signaling through promoter hypomethylation and cross action with transcription nuclear factor-kappa B pathway.
Author: Wang, Tz-Ping|Hsu, Shu-Han|Feng, Hsin-Chun|Huang, Rwei-Fen S
PMID: 22461522
Journal: Asian Pac J Cancer Prev. 2012;13(5):2319-24.
Title: Expression and clinical significance of hedgehog signaling pathway related components in colorectal cancer.
Author: Wang, Hong|Li, Yu-Yuan|Wu, Ying-Ying|Nie, Yu-Qiang
PMID: 22901214
Journal: Int J Mol Sci. 2012;13(8):9419-30.
Title: Scutellaria barbata D. Don inhibits tumor angiogenesis via suppression of Hedgehog pathway in a mouse model of colorectal cancer.
Author: Wei, Lihui|Lin, Jiumao|Xu, Wei|Cai, Qiaoyan|Shen, Aling|Hong, Zhenfeng|Peng, Jun
PMID: 22949805
Journal: PLoS One. 2012;7(9):e45332.
Title: Hedgehog pathway signaling regulates human colon carcinoma HT-29 epithelial cell line apoptosis and cytokine secretion.
Author: Yoshimoto, Agnes N|Bernardazzi, Claudio|Carneiro, Antonio Jose V|Elia, Celeste C S|Martinusso, Cesonia A|Ventura, Grasiella M|Castelo-Branco, Morgana T L|de Souza, Heitor S P
PMID: 23028941
Journal: Int J Cancer. 2013 Jan 15;132(2):E18-25.
Title: Aberrant methylation of the PTCH1 gene promoter region in aberrant crypt foci.
Author: Peng, Liang|Hu, Jingjing|Li, Shujun|Wang, Zhongqiu|Xia, Bingqing|Jiang, Bo|Li, Bingsheng|Zhang, Yu|Wang, Jing|Wang, Xinying
PMID: 22945423
Journal: Int J Oncol. 2013 Nov;43(5):1666-74.
Title: Ursolic acid inhibits colorectal cancer angiogenesis through suppression of multiple signaling pathways.
Author: Lin, Jiumao|Chen, Youqin|Wei, Lihui|Hong, Zhenfeng|Sferra, Thomas J|Peng, Jun
PMID: 24042330
Journal: PLoS Biol. 2013;11(8):e1001623.
Title: Sonic Hedgehog promotes tumor cell survival by inhibiting CDON pro-apoptotic activity.
Author: Delloye-Bourgeois, Celine|Gibert, Benjamin|Rama, Nicolas|Delcros, Jean-Guy|Gadot, Nicolas|Scoazec, Jean-Yves|Krauss, Robert|Bernet, Agnes|Mehlen, Patrick
PMID: 23940460
Journal: Am Surg. 2013 Feb;79(2):198-204.
Title: Expression of GLI1 correlates with expression of lymphangiogenesis proteins, vascular endothelial growth factor C and vascular endothelial growth factor receptor 3, in colorectal cancer.
Author: Hong, Kwang Dae|Lee, Youngseok|Kim, Baek-Hui|Lee, Sun Il|Moon, Hong Young
PMID: 23336661
Journal: Int J Oncol. 2013 Feb;42(2):651-6.
Title: Hedyotis diffusa Willd extract suppresses Sonic hedgehog signaling leading to the inhibition of colorectal cancer angiogenesis.
Author: Lin, Jiumao|Wei, Lihui|Shen, Aling|Cai, Qiaoyan|Xu, Wei|Li, Huang|Zhan, Youzhi|Hong, Zhenfeng|Peng, Jun
PMID: 23291612
Journal: J Dig Dis. 2013 Aug;14(8):417-24.
Title: Aberrant expression of sonic hedgehog pathway in colon cancer and melanosis coli.
Author: Wang, Zhong Chuan|Gao, Jun|Zi, Shu Ming|Yang, Ming|Du, Peng|Cui, Long
PMID: 23551431
Journal: BMC Bioinformatics. 2014 Mar 19;15:78.
Title: ShatterProof: operational detection and quantification of chromothripsis.
Author: Govind, Shaylan K|Zia, Amin|Hennings-Yeomans, Pablo H|Watson, John D|Fraser, Michael|Anghel, Catalina|Wyatt, Alexander W|van der Kwast, Theodorus|Collins, Colin C|McPherson, John D|Bristow, Robert G|Boutros, Paul C
PMID: 24646301
Journal: Oncotarget. 2014 Jun 30;5(12):4492-503.
Title: Mode and specificity of binding of the small molecule GANT61 to GLI determines inhibition of GLI-DNA binding.
Author: Agyeman, Akwasi|Jha, Babal K|Mazumdar, Tapati|Houghton, Janet A
PMID: 24962990
Journal: Anticancer Res. 2014 Nov;34(11):6339-44.
Title: Cyclopamine decreased the expression of Sonic Hedgehog and its downstream genes in colon cancer stem cells.
Author: Batsaikhan, Bat-Erdene|Yoshikawa, Kozo|Kurita, Nobuhiro|Iwata, Takashi|Takasu, Chie|Kashihara, Hideya|Shimada, Mitsuo
PMID: 25368233
Journal: J Microsc Ultrastruct. 2015 Oct-Dec;3(4):169-174.
Title: The significance of sonic hedgehog immunohistochemical expression in colorectal carcinoma.
Author: Al Ghamdi, Doaa|Gomaa, Wafaey|Abulaban, Abdulrhman|Al-Ahwal, Mahmoud|Buhmeida, Abdelbaset|Al-Qahtani, Mohammed|Al-Maghrabi, Jaudah
PMID: 30023196
Journal: Cancer Cell Int. 2015 Oct 9;15:96.
Title: Targeting colorectal cancer stem cells using curcumin and curcumin analogues: insights into the mechanism of the therapeutic efficacy.
Author: Ramasamy, Thamil Selvee|Ayob, Ain Zubaidah|Myint, Hsu Hsu Lynn|Thiagarajah, Sharmanee|Amini, Farahnaz
PMID: 26457069
Journal: Cancers (Basel). 2015 Sep 17;7(3):1885-99.
Title: The Hedgehog Inhibitor Cyclopamine Reduces beta-Catenin-Tcf Transcriptional Activity, Induces E-Cadherin Expression, and Reduces Invasion in Colorectal Cancer Cells.
Author: Qualtrough, David|Rees, Phil|Speight, Beverley|Williams, Ann C|Paraskeva, Christos
PMID: 26393651
Journal: Med Sci Monit. 2015 Aug 8;21:2316-21.
Title: Cabozantinib, a Novel c-Met Inhibitor, Inhibits Colorectal Cancer Development in a Xenograft Model.
Author: Sun, Yinggang|Sun, Liyong|An, Yanxin|Shen, Xin
PMID: 26255947
Journal: Pathol Oncol Res. 2015 Sep;21(4):901-8.
Title: Differential Expression of Sonic Hedgehog Protein in Human Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma.
Author: Al-Bahrani, Redha|Nagamori, Seishi|Leng, Roger|Petryk, Anna|Sergi, Consolato
PMID: 25740074
Journal: Tumour Biol. 2015 Mar;36(3):2013-21.
Title: beta1 integrin mediates colorectal cancer cell proliferation and migration through regulation of the Hedgehog pathway.
Author: Song, Jia|Zhang, Jixiang|Wang, Jing|Wang, Jun|Guo, Xufeng|Dong, Weiguo
PMID: 25387809
Journal: Oncotarget. 2016 Feb 16;7(7):7667-82.
Title: Sonic hedgehog inhibitors prevent colitis-associated cancer via orchestrated mechanisms of IL-6/gp130 inhibition, 15-PGDH induction, Bcl-2 abrogation, and tumorsphere inhibition.
Author: Kangwan, Napapan|Kim, Yoon-Jae|Han, Young Min|Jeong, Migyeong|Park, Jong-Min|Go, Eun-Jin|Hahm, Ki-Baik
PMID: 26716648
Journal: Mol Med Rep. 2016 Jun;13(6):5276-82.
Title: Oleanolic acid inhibits colorectal cancer angiogenesis in vivo and in vitro via suppression of STAT3 and Hedgehog pathways.
Author: Li, Li|Lin, Jiumao|Sun, Guodong|Wei, Lihui|Shen, Aling|Zhang, Mingyue|Peng, Jun
PMID: 27108756
Journal: Oncol Res. 2016;24(3):137-44.
Title: Knockdown of PFTAIRE Protein Kinase 1 (PFTK1) Inhibits Proliferation, Invasion, and EMT in Colon Cancer Cells.
Author: Zhu, Jiankang|Liu, Chongzhong|Liu, Fengyue|Wang, Yadong|Zhu, Min
PMID: 27458094
Journal: Iran J Basic Med Sci. 2016 Nov;19(11):1171-1176.
Title: The hedgehog/Gli-1 signaling pathways is involved in the inhibitory effect of resveratrol on human colorectal cancer HCT116 cells.
Author: Du, Zhou|Zhou, Feng|Jia, Zengrong|Zheng, Beishi|Han, Shaoliang|Cheng, Jun|Zhu, Guanbao|Huang, Ping
PMID: 27917272
Journal: Oncol Res. 2017 May 24;25(5):681-689.
Title: FOXR2 Promotes the Proliferation, Invasion, and Epithelial-Mesenchymal Transition in Human Colorectal Cancer Cells.
Author: Lu, Sheng-Qiang|Qiu, Yan|Dai, Wei-Jie|Zhang, Xiao-Yu
PMID: 28548041
Journal: Exp Ther Med. 2017 May;13(5):2529-2536.
Title: Smoothened antagonist GDC-0449 (Vismodegib) inhibits proliferation and triggers apoptosis in colon cancer cell lines.
Author: Wu, Chuanqing|Hu, Shaobo|Cheng, Ji|Wang, Guobin|Tao, Kaixiong
PMID: 28565875
Journal: Int J Cancer. 2017 Dec 15;141(12):2537-2550.
Title: Low folate metabolic stress reprograms DNA methylation-activated sonic hedgehog signaling to mediate cancer stem cell-like signatures and invasive tumour stage-specific malignancy of human colorectal cancers.
Author: Feng, Hsin-Chun|Lin, Jhuan-Yu|Hsu, Shu-Han|Lan, Wen-Yu|Kuo, Chang-Sheng|Tian, Yu-Feng|Sun, Ding-Ping|Huang, Rwei-Fen Syu
PMID: 28833104
Journal: Cell Rep. 2017 Dec 5;21(10):2813-2828.
Title: Non-Canonical Hedgehog Signaling Is a Positive Regulator of the WNT Pathway and Is Required for the Survival of Colon Cancer Stem Cells.
Author: Regan, Joseph L|Schumacher, Dirk|Staudte, Stephanie|Steffen, Andreas|Haybaeck, Johannes|Keilholz, Ulrich|Schweiger, Caroline|Golob-Schwarzl, Nicole|Mumberg, Dominik|Henderson, David|Lehrach, Hans|Regenbrecht, Christian R A|Schafer, Reinhold|Lange, Martin
PMID: 29212028
Journal: PLoS One. 2018 Jan 2;13(1):e0190070.
Title: Macrophage conditioned medium promotes colorectal cancer stem cell phenotype via the hedgehog signaling pathway.
Author: Fan, Fan|Wang, Rui|Boulbes, Delphine R|Zhang, Huiyuan|Watowich, Stephanie S|Xia, Ling|Ye, Xiangcang|Bhattacharya, Rajat|Ellis, Lee M
PMID: 29293549
Journal: World J Gastroenterol. 2018 Oct 21;24(39):4428-4435.
Title: Novel targeting approaches and signaling pathways of colorectal cancer: An insight.
Author: Tiwari, Ankita|Saraf, Shivani|Verma, Amit|Panda, Pritish Kumar|Jain, Sanjay K
PMID: 30357011
Journal: Biomed Res Int. 2018 Sep 27;2018:2594076.
Title: A Bioinformatic Profile of Gene Expression of Colorectal Carcinoma Derived Organoids.
Author: A, Peng|Xu, Xinyi|Wang, Chenglin|Ye, Ling|Yang, Jing
PMID: 30363662