Primary Site >> Colorectal Cancer
Gene >> SHH
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Ref: The patched/hedgehog/smoothened signalling pathway in human breast cancer: no evidence for H133Y SHH, PTCH and SMO mutations. PMID: 10505029 |
Ref: Failure of a medulloblastoma-derived mutant of SUFU to suppress WNT signaling. PMID: 15077159 Ref: Expression of Sonic hedgehog pathway genes is altered in colonic neoplasia. PMID: 15258993 |
Ref: Identification and characterization of rat Desert hedgehog and Indian hedgehog genes in silico. PMID: 15645142 Ref: Comparative genomics on Sonic hedgehog orthologs. PMID: 16142377 |
Ref: Sonic hedgehog mRNA expression by real-time quantitative PCR in normal and tumor tissues from colorectal cancer patients. PMID: 16473672 Ref: Sonic Hedgehog-dependent proliferation in a series of patients with colorectal cancer. PMID: 16701100 Ref: Hedgehog signaling pathway and gastrointestinal stem cell signaling network (review). PMID: 17089004 |
Ref: Sonic hedgehog-Gli1 pathway in colorectal adenocarcinomas. PMID: 17461467 Ref: Isolation and characterization of two novel colon cancer cell lines from Chinese patients. PMID: 17554590 Ref: Hedgehog signaling pathway is inactive in colorectal cancer cell lines. PMID: 17683069 Ref: Transcriptional silencing of hedgehog-interacting protein by CpG hypermethylation and chromatic structure in human gastrointestinal cancer. PMID: 17724792 |
Ref: Hedgehog signaling is involved in differentiation of normal colonic tissue rather than in tumor proliferation. PMID: 19280222 Ref: Sonic hedgehog relates to colorectal carcinogenesis. PMID: 19662327 |
Ref: Distinct expression patterns of hedgehog ligands between cultured and primary colorectal cancers are associated with aberrant methylation of their promoters. PMID: 19856079 Ref: Hedgehog pathway activity is required for the lethality and intestinal phenotypes of mice with hyperactive Wnt signaling. PMID: 19861162 Ref: PTCH1, a receptor of Hedgehog signaling pathway, is correlated with metastatic potential of colorectal cancer. PMID: 20230186 |
Ref: Differential expression profiles of the Hedgehog signaling pathway between microsatellite-stable and microsatellite-unstable colorectal cancers. PMID: 21725600 Ref: Potential applications of curcumin and its novel synthetic analogs and nanotechnology-based formulations in cancer prevention and therapy. PMID: 21859497 Ref: Cyclopamine blocked the growth of colorectal cancer SW116 cells by modulating some target genes of Gli1 in vitro. PMID: 21940310 |
Ref: A distinct DNA methylation profile associated with microsatellite and chromosomal stable sporadic colorectal cancers. PMID: 21455990 Ref: Abrogation of Gli3 expression suppresses the growth of colon cancer cells via activation of p53. PMID: 22227409 Ref: Folate deprivation enhances invasiveness of human colon cancer cells mediated by activation of sonic hedgehog signaling through promoter hypomethylation and cross action with transcription nuclear factor-kappa B pathway. PMID: 22461522 Ref: Expression and clinical significance of hedgehog signaling pathway related components in colorectal cancer. PMID: 22901214 Ref: Scutellaria barbata D. Don inhibits tumor angiogenesis via suppression of Hedgehog pathway in a mouse model of colorectal cancer. PMID: 22949805 Ref: Hedgehog pathway signaling regulates human colon carcinoma HT-29 epithelial cell line apoptosis and cytokine secretion. PMID: 23028941 |
Ref: Aberrant methylation of the PTCH1 gene promoter region in aberrant crypt foci. PMID: 22945423 Ref: Hedyotis diffusa Willd extract suppresses Sonic hedgehog signaling leading to the inhibition of colorectal cancer angiogenesis. PMID: 23291612 Ref: Expression of GLI1 correlates with expression of lymphangiogenesis proteins, vascular endothelial growth factor C and vascular endothelial growth factor receptor 3, in colorectal cancer. PMID: 23336661 Ref: Aberrant expression of sonic hedgehog pathway in colon cancer and melanosis coli. PMID: 23551431 Ref: Sonic Hedgehog promotes tumor cell survival by inhibiting CDON pro-apoptotic activity. PMID: 23940460 Ref: Ursolic acid inhibits colorectal cancer angiogenesis through suppression of multiple signaling pathways. PMID: 24042330 |
Ref: ShatterProof: operational detection and quantification of chromothripsis. PMID: 24646301 Ref: Mode and specificity of binding of the small molecule GANT61 to GLI determines inhibition of GLI-DNA binding. PMID: 24962990 Ref: Cyclopamine decreased the expression of Sonic Hedgehog and its downstream genes in colon cancer stem cells. PMID: 25368233 |
Ref: beta1 integrin mediates colorectal cancer cell proliferation and migration through regulation of the Hedgehog pathway. PMID: 25387809 Ref: Differential Expression of Sonic Hedgehog Protein in Human Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma. PMID: 25740074 Ref: Cabozantinib, a Novel c-Met Inhibitor, Inhibits Colorectal Cancer Development in a Xenograft Model. PMID: 26255947 Ref: The Hedgehog Inhibitor Cyclopamine Reduces beta-Catenin-Tcf Transcriptional Activity, Induces E-Cadherin Expression, and Reduces Invasion in Colorectal Cancer Cells. PMID: 26393651 Ref: Targeting colorectal cancer stem cells using curcumin and curcumin analogues: insights into the mechanism of the therapeutic efficacy. PMID: 26457069 Ref: The significance of sonic hedgehog immunohistochemical expression in colorectal carcinoma. PMID: 30023196 |
Ref: Sonic hedgehog inhibitors prevent colitis-associated cancer via orchestrated mechanisms of IL-6/gp130 inhibition, 15-PGDH induction, Bcl-2 abrogation, and tumorsphere inhibition. PMID: 26716648 Ref: Oleanolic acid inhibits colorectal cancer angiogenesis in vivo and in vitro via suppression of STAT3 and Hedgehog pathways. PMID: 27108756 Ref: Knockdown of PFTAIRE Protein Kinase 1 (PFTK1) Inhibits Proliferation, Invasion, and EMT in Colon Cancer Cells. PMID: 27458094 Ref: The hedgehog/Gli-1 signaling pathways is involved in the inhibitory effect of resveratrol on human colorectal cancer HCT116 cells. PMID: 27917272 |
Ref: FOXR2 Promotes the Proliferation, Invasion, and Epithelial-Mesenchymal Transition in Human Colorectal Cancer Cells. PMID: 28548041 Ref: Smoothened antagonist GDC-0449 (Vismodegib) inhibits proliferation and triggers apoptosis in colon cancer cell lines. PMID: 28565875 Ref: Low folate metabolic stress reprograms DNA methylation-activated sonic hedgehog signaling to mediate cancer stem cell-like signatures and invasive tumour stage-specific malignancy of human colorectal cancers. PMID: 28833104 Ref: Non-Canonical Hedgehog Signaling Is a Positive Regulator of the WNT Pathway and Is Required for the Survival of Colon Cancer Stem Cells. PMID: 29212028 |
Ref: Macrophage conditioned medium promotes colorectal cancer stem cell phenotype via the hedgehog signaling pathway. PMID: 29293549 Ref: Novel targeting approaches and signaling pathways of colorectal cancer: An insight. PMID: 30357011 Ref: A Bioinformatic Profile of Gene Expression of Colorectal Carcinoma Derived Organoids. PMID: 30363662 |