Primary Site >> Liver Cancer

Gene >> SERPINE1

Journal: Eur J Clin Invest. 1988 Dec;18(6):595-9.
Title: Plasminogen activators and plasminogen activator inhibitor in malignant and non-malignant ascitic fluid.
Author: Huber, K|Wojta, J|Kirchheimer, J C|Ermler, D|Binder, B R
PMID: 2852112
Journal: Ann Fr Anesth Reanim. 1989;8(1):4-11.
Title: [Fibrinolytic activity in patients undergoing hepatic transplantation].
Author: Houvenaeghel, M|Andreoli, S|Achilli-Cornesse, M E|Boutiere, B|Arnoux, D|Le Treut, Y P|Manelli, J C
PMID: 2496627
Journal: Thromb Haemost. 1989 Sep 29;62(2):723-8.
Title: Plasminogen activator inhibitor 1: biosynthesis and mRNA level are increased by insulin in cultured human hepatocytes.
Author: Kooistra, T|Bosma, P J|Tons, H A|van den Berg, A P|Meyer, P|Princen, H M
PMID: 2683191
Journal: Biochim Biophys Acta. 1992 Feb 14;1138(2):149-56.
Title: Human HuH-7 hepatoma cells express urokinase and plasminogen activator inhibitor-1: identification, characterization and regulation by inflammatory mediators.
Author: Arndt, A|Murphy, P|Hart, D A
PMID: 1371701
Journal: Thromb Haemost. 1995 Sep;74(3):864-7.
Title: Diagnostic efficacy of plasma urokinase-type plasminogen activator and plasminogen activator inhibitor-2 in differentiation of hepatocellular carcinoma from cirrhosis.
Author: Song, K S|Lee, A|Choi, J R|Kwon, O H
PMID: 8571313
Journal: Hepatogastroenterology. 1996 Nov-Dec;43(12):1410-4.
Title: Postoperative adjuvant arterial infusion chemotherapy for patients with hepatocellular carcinoma.
Author: Nakashima, K|Kitano, S|Kim, Y I|Aramaki, M|Kawano, K
PMID: 8975940
Journal: Gan To Kagaku Ryoho. 1998 Apr;25(5):751-5.
Title: [Percutaneous ethanol and acetic acid injection for liver metastasis from colon cancer--two case reports].
Author: Yamamoto, S|Iguchi, Y|Shibata, N|Takesue, M|Tsunoda, T|Sato, K
PMID: 9571976
Journal: Oncol Res. 1998;10(5):255-62.
Title: Human hepatoma cells rich in P-glycoprotein display enhanced in vitro invasive properties compared to P-glycoprotein-poor hepatoma cells.
Author: Bjornland, K|Lehne, G|Johansen, H T|Fodstad, O|Rugstad, H E|Aasen, A O|Ree, A H
PMID: 9802060
Journal: Zhonghua Wai Ke Za Zhi. 1998 Aug;36(8):474-6.
Title: [Inhibitor of plasminogen activator 1 (PAI-1) in hepatocellular carcinoma].
Author: Zheng, Q|Tang, Z|Wu, Z|Shi, D|Song, H
PMID: 11825444
Journal: Zhonghua Wai Ke Za Zhi. 1998 Nov;36(11):687-9.
Title: [Changes of PAI-1 and biological behaviour of human hepatocellular carcinoma in metastatic model of nude mice].
Author: Zheng, Q|Tang, Z|Xue, Q
PMID: 11825501
Journal: J Gastroenterol Hepatol. 2000 Apr;15(4):422-30.
Title: Clinical significance of urokinase-type plasminogen activator activity in hepatocellular carcinoma.
Author: Itoh, T|Hayashi, Y|Kanamaru, T|Morita, Y|Suzuki, S|Wang, W|Zhou, L|Rui, J A|Yamamoto, M|Kuroda, Y|Itoh, H
PMID: 10824888
Journal: Pathol Int. 2000 May;50(5):392-7.
Title: Expression of urokinase-type plasminogen activator, urokinase-type plasminogen activator receptor, and plasminogen activator inhibitor-1 and -2 in hepatocellular carcinoma.
Author: Zhou, L|Hayashi, Y|Itoh, T|Wang, W|Rui, J|Itoh, H
PMID: 10849328
Journal: J Cancer Res Clin Oncol. 2000 Nov;126(11):641-6.
Title: Invasion and metastasis of hepatocellular carcinoma in relation to urokinase-type plasminogen activator, its receptor and inhibitor.
Author: Zheng, Q|Tang, Z Y|Xue, Q|Shi, D R|Song, H Y|Tang, H B
PMID: 11079728
Journal: World J Gastroenterol. 2001 Oct;7(5):597-601.
Title: Metastatic human hepatocellular carcinoma models in nude mice and cell line with metastatic potential.
Author: Tang, Z Y|Sun, F X|Tian, J|Ye, S L|Liu, Y K|Liu, K D|Xue, Q|Chen, J|Xia, J L|Qin, L X|Sun, S L|Wang, L|Zhou, J|Li, Y|Ma, Z C|Zhou, X D|Wu, Z Q|Lin, Z Y|Yang, B H
PMID: 11819839
Journal: Environ Health Perspect. 2001 Aug;109(8):833-7.
Title: Variability in aflatoxin-albumin adduct levels and effects of hepatitis B and C virus infection and glutathione S-transferase M1 and T1 genotype.
Author: Ahsan, H|Wang, L Y|Chen, C J|Tsai, W Y|Santella, R M
PMID: 11564620
Journal: Onkologie. 2001 Jun;24(3):238-44.
Title: Clinical relevance of the plasminogen activator inhibitor type 1--a multifaceted proteolytic factor.
Author: Harbeck, N|Kruger, A|Sinz, S|Kates, R E|Thomssen, C|Schmitt, M|Janicke, F
PMID: 11455216
Journal: World J Gastroenterol. 2002 Jun;8(3):385-92.
Title: The prognostic molecular markers in hepatocellular carcinoma.
Author: Qin, Lun-Xiu|Tang, Zhao-You
PMID: 12046056
Journal: J Surg Oncol. 2003 Mar;82(3):184-93.
Title: Quantitative expression of protein markers of plasminogen activation system in prognosis of colorectal cancer.
Author: Seetoo, Da-Qiang|Crowe, Philip J|Russell, Pamela J|Yang, Jia-Lin
PMID: 12619063
Journal: Digestion. 2005;71(2):78-91.
Title: Altered expression of TGF-beta receptors in hepatocellular carcinoma--effects of a constitutively active TGF-beta type I receptor mutant.
Author: Musch, Annemarie|Rabe, Christian|Paik, Mignon-Denise|Berna, Marc Jean|Schmitz, Volker|Hoffmann, Per|Nischalke, Hans Dieter|Sauerbruch, Tilman|Caselmann, Wolfgang H
PMID: 15775675
Journal: J Chin Med Assoc. 2005 Apr;68(4):155-9.
Title: Percutaneous ablation therapy for hepatocellular carcinoma: current practice and future perspectives.
Author: Huo, Teh-Ia|Huang, Yi-Hsiang|Wu, Jaw-Ching
PMID: 15850062
Journal: Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2006 Mar;22(2):185-8.
Title: [The effects of tumor antigen gene OVA66 on biological characteristics of tumor cells].
Author: Li, Mei-xing|Wang, Shu-jun|Wang, Ying|Zhang, Hui-zhen|You, Qiang|Zhou, Guang-yan|Ge, Hai-liang
PMID: 16507255
Journal: BMC Gastroenterol. 2007 Dec 13;7:45.
Title: Percutaneous ultrasound-guided ablation of BW7756-hepatoma using ethanol or acetic acid in a rat model.
Author: Zardi, Enrico M|Borzomati, Domenico|Cacciapaglia, Fabio|Picardi, Antonio|Valeri, Sergio|Bianchi, Antonella|Galeotti, Tommaso|Coppolino, Giusy|Coppola, Roberto|Afeltra, Antonella
PMID: 18078519
Journal: Toxicology. 2008 Apr 18;246(2-3):242-7.
Title: Repression of Ah receptor and induction of transforming growth factor-beta genes in DEN-induced mouse liver tumors.
Author: Peng, Li|Mayhew, Christopher N|Schnekenburger, Michael|Knudsen, Erik S|Puga, Alvaro
PMID: 18282651
Journal: Anticancer Res. 2008 Jan-Feb;28(1A):223-8.
Title: PAI-1, t-PA and circulating hTERT DNA as related to virus infection in liver carcinogenesis.
Author: Divella, Rosa|Lacalamita, Rosanna|Tommasi, Stefania|Coviello, Maria|Daniele, Antonella|Garrisi, Vito Michele|Abbate, Ines|Simone, Giovanni|Gadaleta, Cosimo|Paradiso, Angelo|Quaranta, Michele
PMID: 18383849
Journal: Cell Biol Int. 2008 Oct;32(10):1310-7.
Title: Ghrelin attenuates plasminogen activator inhibitor-1 production induced by tumor necrosis factor-alpha in HepG2 cells via NF-kappaB pathway.
Author: Ding, Liying|Liu, Guoliang|Guo, Wenshi|Zhao, Hong|Zong, Zhihong
PMID: 18700166
Journal: J Thromb Thrombolysis. 2009 Jul;28(1):70-3.
Title: MTHFR C677TT, PAI1 4G-4G, V Leiden Q506, and prothrombin G20210A in hepatocellular carcinoma with and without portal vein thrombosis.
Author: D'Amico, Mario|Pasta, Linda|Sammarco, Piero
PMID: 18618228
Journal: Biochem Biophys Res Commun. 2009 Sep 4;386(4):757-61.
Title: Forkhead transcription factor FoxO1 inhibits insulin- and transforming growth factor-beta-stimulated plasminogen activator inhibitor-1 expression.
Author: Jung, Yun-A|Lee, Kyeong-Min|Kim, Mi-Kyung|Jung, Gwon-Soo|Seo, Ye-Jin|Kim, Hye-Soon|Cho, Ho-Chan|Lee, Ki-Up|Park, Keun-Gyu|Lee, In-Kyu
PMID: 19563779
Journal: Hepatol Res. 2009 Oct;39(10):998-1009.
Title: Plumbagin inhibits invasion and migration of liver cancer HepG2 cells by decreasing productions of matrix metalloproteinase-2 and urokinase- plasminogen activator.
Author: Shih, Yuan-Wei|Lee, Yi-Chieh|Wu, Pei-Fen|Lee, Yuan-Bing|Chiang, Tai-An
PMID: 19624766
Journal: Biochem Biophys Res Commun. 2010 Feb 19;392(4):473-8.
Title: Emodin inhibits the growth of hepatoma cells: finding the common anti-cancer pathway using Huh7, Hep3B, and HepG2 cells.
Author: Hsu, Chin-Mu|Hsu, Yu-An|Tsai, Yuhsin|Shieh, Fa-Kuen|Huang, Su-Hua|Wan, Lei|Tsai, Fuu-Jen
PMID: 19895793
Journal: Int J Oncol. 2010 Dec;37(6):1627-38.
Title: Rodent-specific hypoxia response elements enhance PAI-1 expression through HIF-1 or HIF-2 in mouse hepatoma cells.
Author: Ahn, Yong-Tae|Chua, Mei-Sze|Whitlock, James P Jr|Shin, Yong-Chil|Song, Woon-Heung|Kim, Yongkuk|Eom, Chi-Yong|An, Won Gun
PMID: 21042733
Journal: Ann Surg Oncol. 2010 Dec;17(12):3394-401.
Title: Evaluation of the association of urokinase plasminogen activator system gene polymorphisms with susceptibility and pathological development of hepatocellular carcinoma.
Author: Weng, Chia-Jui|Tsai, Chiung-Man|Chen, Yi-Chen|Hsieh, Yi-Hsien|Lin, Chiao-Wen|Liu, Yu-Fan|Su, Shih-Chi|Chen, Mu-Kuan|Yang, Shun-Fa
PMID: 20706793
Journal: Toxicology. 2011 Apr 28;283(1):8-17.
Title: Concomitant apoptosis and regeneration of liver cells as a mechanism of liver-tumor promotion by beta-naphthoflavone involving TNFalpha-signaling due to oxidative cellular stress in rats.
Author: Kuwata, Kazunori|Shibutani, Makoto|Hayashi, Hitomi|Shimamoto, Keisuke|Hayashi, Shim-Mo|Suzuki, Kazuhiko|Mitsumori, Kunitoshi
PMID: 21295105
Journal: Oncol Rep. 2011 Aug;26(2):511-7.
Title: Various effects of hepatoma-derived growth factor on cell growth, migration and invasion of breast cancer and prostate cancer cells.
Author: Guo, Zhenying|He, Yuanzheng|Wang, Shuangshuang|Zhang, Aixia|Zhao, Ping|Gao, Chongfeng|Cao, Brian
PMID: 21567096
Journal: Thromb Res. 2011 Nov;128(5):e81-5.
Title: PPARgamma activation induces acute PAI-1 gene expression in the liver but not in adipose tissues of diabetic model mice.
Author: Oishi, Katsutaka|Tomita, Tatsunosuke|Itoh, Nanako|Ohkura, Naoki
PMID: 21757225
Journal: Indian J Cancer. 2011 Jul-Sep;48(3):339-44.
Title: Transarterial chemoembolization for hepatocellular carcinoma: significance of extrahepatic collateral supply.
Author: Paul, S B|Gamanagatti, S R|Mukund, A|Abbas, S Z|Acharya, S K
PMID: 21921335
Journal: Hepatology. 2012 Jan;55(1):121-31.
Title: Transforming growth factor-beta signaling promotes hepatocarcinogenesis induced by p53 loss.
Author: Morris, Shelli M|Baek, Ji Yeon|Koszarek, Amanda|Kanngurn, Samornmas|Knoblaugh, Sue E|Grady, William M
PMID: 21898503
Journal: Mol Cell Proteomics. 2012 Apr;11(4):M111.011270.
Title: Stable isotope labeling with amino acids in cell culture (SILAC)-based quantitative proteomics study of a thyroid hormone-regulated secretome in human hepatoma cells.
Author: Chen, Cheng-Yi|Chi, Lang-Ming|Chi, Hsiang-Cheng|Tsai, Ming-Ming|Tsai, Chung-Ying|Tseng, Yi-Hsin|Lin, Yang-Hsiang|Chen, Wei-Jan|Huang, Ya-Hui|Lin, Kwang-Huei
PMID: 22171322
Journal: Evid Based Complement Alternat Med. 2012;2012:965846.
Title: Korean Red Ginseng Suppresses Metastasis of Human Hepatoma SK-Hep1 Cells by Inhibiting Matrix Metalloproteinase-2/-9 and Urokinase Plasminogen Activator.
Author: Ho, Yu-Ling|Li, Kun-Cheng|Chao, Wei|Chang, Yuan-Shiun|Huang, Guan-Jhong
PMID: 22570673
Journal: J Toxicol Sci. 2012;37(3):517-26.
Title: Threshold dose of liver tumor promoting effect of beta-naphthoflavone in rats.
Author: Hayashi, Hitomi|Taniai, Eriko|Morita, Reiko|Yafune, Atsunori|Suzuki, Kazuhiko|Shibutani, Makoto|Mitsumori, Kunitoshi
PMID: 22687991
Journal: Mol Nutr Food Res. 2012 Aug;56(8):1304-14.
Title: Molecular mechanism inhibiting human hepatocarcinoma cell invasion by 6-shogaol and 6-gingerol.
Author: Weng, Chia-Jui|Chou, Chai-Ping|Ho, Chi-Tang|Yen, Gow-Chin
PMID: 22714996
Journal: Cancer Genomics Proteomics. 2012 Jul-Aug;9(4):193-8.
Title: Influence of plasminogen activator inhibitor-1 (SERPINE1) 4G/5G polymorphism on circulating SERPINE-1 antigen expression in HCC associated with viral infection.
Author: Divella, Rosa|Mazzocca, Antonio|Gadaleta, Cosimo|Simone, Giovanni|Paradiso, Angelo|Quaranta, Michele|Daniele, Antonella
PMID: 22798504
Journal: Int J Vasc Med. 2013;2013:717480.
Title: Thrombophilic Genetic Factors PAI-1, MTHFRC677T, V Leiden 506Q, and Prothrombin 20210A in Noncirrhotic Portal Vein Thrombosis and Budd-Chiari Syndrome in a Caucasian Population.
Author: D'Amico, Mario|Sammarco, Pietro|Pasta, Linda
PMID: 24455271
Journal: Oncol Rep. 2014 Feb;31(2):885-93.
Title: Enhancement of DEN-induced liver tumourigenesis in hepatocyte-specific Lass2-knockout mice coincident with upregulation of the TGF-beta1-Smad4-PAI-1 axis.
Author: Chen, Lufang|Lu, Xiaodong|Zeng, Tiantian|Chen, Yuanyuan|Chen, Qian|Wu, Weijiang|Yan, Xun|Cai, Honghua|Zhang, Zhijian|Shao, Qixiang|Qin, Wenxin
PMID: 24337404
Journal: J Hepatol. 2014 Aug;61(2):278-85.
Title: Pre-retrieval reperfusion decreases cancer recurrence after rat ischemic liver graft transplantation.
Author: Oldani, Graziano|Crowe, Lindsey A|Orci, Lorenzo A|Slits, Florence|Rubbia-Brandt, Laura|de Vito, Claudio|Morel, Philippe|Mentha, Gilles|Berney, Thierry|Vallee, Jean-Paul|Lacotte, Stephanie|Toso, Christian
PMID: 24713189
Journal: J Ethnopharmacol. 2014;151(1):198-209.
Title: Compound Astragalus and Salvia miltiorrhiza extract suppresses hepatocellular carcinoma progression by inhibiting fibrosis and PAI-1 mRNA transcription.
Author: Rui, Wenjuan|Xie, Lei|Liu, Xin|He, Shufang|Wu, Chao|Zhang, Xiaoxiang|Zhang, Linjie|Yang, Yan
PMID: 24247078
Journal: Hepatology. 2015 Mar;61(3):930-41.
Title: Axl activates autocrine transforming growth factor-beta signaling in hepatocellular carcinoma.
Author: Reichl, Patrick|Dengler, Mirko|van Zijl, Franziska|Huber, Heidemarie|Fuhrlinger, Gerhard|Reichel, Christian|Sieghart, Wolfgang|Peck-Radosavljevic, Markus|Grubinger, Markus|Mikulits, Wolfgang
PMID: 25251599
Journal: Exp Cell Res. 2015 Feb 1;331(1):46-57.
Title: HIF-2alpha-dependent PAI-1 induction contributes to angiogenesis in hepatocellular carcinoma.
Author: Geis, Theresa|Doring, Claudia|Popp, Rudiger|Grossmann, Nina|Fleming, Ingrid|Hansmann, Martin-Leo|Dehne, Nathalie|Brune, Bernhard
PMID: 25489981
Journal: J Ethnopharmacol. 2015 Jul 1;169:219-28.
Title: Compound Astragalus and Salvia miltiorrhiza extracts modulate MAPK-regulated TGF-beta/Smad signaling in hepatocellular carcinoma by multi-target mechanism.
Author: Boye, Alex|Wu, Chao|Jiang, Yufeng|Wang, Jiyu|Wu, Jiajun|Yang, Xiaochuan|Yang, Yan
PMID: 25934513
Journal: Transl Oncol. 2015 Aug;8(4):273-8.
Title: Circulating Levels of PAI-1 and SERPINE1 4G/4G Polymorphism Are Predictive of Poor Prognosis in HCC Patients Undergoing TACE.
Author: Divella, Rosa|Daniele, Antonella|Abbate, Ines|Savino, Eufemia|Casamassima, Porzia|Sciortino, Giancarlo|Simone, Giovanni|Gadaleta-Caldarola, Gennaro|Fazio, Vito|Gadaleta, Cosimo Damiano|Sabba, Carlo|Mazzocca, Antonio
PMID: 26310373
Journal: Toxicol Lett. 2016 Jul 25;255:1-10.
Title: Chlordecone potentiates hepatic fibrosis in chronic liver injury induced by carbon tetrachloride in mice.
Author: Tabet, Elise|Genet, Valentine|Tiaho, Francois|Lucas-Clerc, Catherine|Gelu-Simeon, Moana|Piquet-Pellorce, Claire|Samson, Michel
PMID: 26853152
Journal: Int J Mol Sci. 2016 Apr 16;17(4):577.
Title: Up-Regulation of PAI-1 and Down-Regulation of uPA Are Involved in Suppression of Invasiveness and Motility of Hepatocellular Carcinoma Cells by a Natural Compound Berberine.
Author: Wang, Xuanbin|Wang, Ning|Li, Hongliang|Liu, Ming|Cao, Fengjun|Yu, Xianjun|Zhang, Jingxuan|Tan, Yan|Xiang, Longchao|Feng, Yibin
PMID: 27092498
Journal: J Clin Exp Hepatol. 2016 Mar;6(1):10-4.
Title: PAI-1 4G-4G, MTHFR 677TT, V Leiden 506Q, and Prothrombin 20210A in Splanchnic Vein Thrombosis: Analysis of Individual Patient Data From Three Prospective Studies.
Author: Pasta, Linda|Pasta, Francesca|D'Amico, Mario
PMID: 27194890
Journal: Oncol Lett. 2018 Apr;15(4):4867-4872.
Title: Mitogen-activated protein kinase inhibitors reduce the nuclear accumulation of phosphorylated Smads by inhibiting Imp 7 or Imp 8 in HepG2 cells.
Author: Hu, Xiangpeng|Kan, Hongwei|Boye, Alex|Jiang, Yufeng|Wu, Chao|Yang, Yan
PMID: 29552126
Journal: Mol Carcinog. 2018 Aug;57(8):978-987.
Title: Identification of chromatin-accessible domains in non-alcoholic steatohepatitis-derived hepatocellular carcinoma.
Author: Dechassa, Mekonnen L|Tryndyak, Volodymyr|de Conti, Aline|Xiao, Wenming|Beland, Frederick A|Pogribny, Igor P
PMID: 29603380
Journal: iScience. 2018 Apr 27;2:210-220.
Title: Functional Modulation of Gene Expression by Ultraconserved Long Non-coding RNA TUC338 during Growth of Human Hepatocellular Carcinoma.
Author: Wen, Hui-Ju|Walsh, Michael P|Yan, Irene K|Takahashi, Kenji|Fields, Alan|Patel, Tushar
PMID: 29888750
Journal: Front Med (Lausanne). 2018 Sep 11;5:253.
Title: Fibrinolytic System Changes in Liver Surgery: A Pilot Observational Study.
Author: Ozolina, Agnese|Nemme, Janis|Ozolins, Arturs|Bjertnaes, Lars J|Vanags, Indulis|Gardovskis, Janis|Viksna, Ludmila|Krumina, Angelika
PMID: 30255021