Primary Site >> Colorectal Cancer
Gene >> RUNX3
| 1. | |||||||||||
| Journal: | Lab Invest. 2004 Apr;84(4):479-84. | ||||||||||
| Title: | Methylation of RUNX3 in various types of human cancers and premalignant stages of gastric carcinoma. | ||||||||||
| Author: | Kim, Tai Young|Lee, Hyeon Joo|Hwang, Kyu Sang|Lee, Minjin|Kim, Jae Won|Bang, Yung-Jue|Kang, Gyeong Hoon | ||||||||||
| PMID: | 14968123 | ||||||||||
| 2. | |||||||||||
| Journal: | Oncogene. 2004 Sep 2;23(40):6736-42. | ||||||||||
| Title: | Promoter hypermethylation downregulates RUNX3 gene expression in colorectal cancer cell lines. | ||||||||||
| Author: | Ku, Ja-Lok|Kang, Sung-Bum|Shin, Young-Kyoung|Kang, Hio Chung|Hong, Sung-Hye|Kim, Il-Jin|Shin, Joo-Ho|Han, Inn-Oc|Park, Jae-Gahb | ||||||||||
| PMID: | 15273736 | ||||||||||
| 3. | |||||||||||
| Journal: | Int J Cancer. 2004 Dec 10;112(5):754-9. | ||||||||||
| Title: | Epigenetic inactivation of RUNX3 in microsatellite unstable sporadic colon cancers. | ||||||||||
| Author: | Goel, Ajay|Arnold, Christian N|Tassone, Pierfrancesco|Chang, Dong K|Niedzwiecki, Donna|Dowell, Jeannette M|Wasserman, Linda|Compton, Carolyn|Mayer, Robert J|Bertagnolli, Monica M|Boland, C Richard | ||||||||||
| PMID: | 15386381 | ||||||||||
| 4. | |||||||||||
| Journal: | Anticancer Res. 2005 Jul-Aug;25(4):2627-30. | ||||||||||
| Title: | RUNX3 promoter region is specifically methylated in poorly-differentiated colorectal cancer. | ||||||||||
| Author: | Imamura, Yasuhiro|Hibi, Kenji|Koike, Masahiko|Fujiwara, Michitaka|Kodera, Yasuhiro|Ito, Katsuki|Nakao, Akimasa | ||||||||||
| PMID: | 16080503 | ||||||||||
| 5. | |||||||||||
| Journal: | Anticancer Res. 2006 Jan-Feb;26(1A):55-8. | ||||||||||
| Title: | Lymph node metastasis is infrequent in patients with highly-methylated colorectal cancer. | ||||||||||
| Author: | Hibi, Kenji|Nakao, Akimasa | ||||||||||
| PMID: | 16475679 | ||||||||||
| 6. | |||||||||||
| Journal: | Int J Mol Med. 2006 Dec;18(6):1019-23. | ||||||||||
| Title: | Hedgehog signaling pathway and gastrointestinal stem cell signaling network (review). | ||||||||||
| Author: | Katoh, Yuriko|Katoh, Masaru | ||||||||||
| PMID: | 17089004 | ||||||||||
| 7. | |||||||||||
| Journal: | Gastroenterology. 2007 Jan;132(1):127-38. | ||||||||||
| Title: | The CpG island methylator phenotype and chromosomal instability are inversely correlated in sporadic colorectal cancer. | ||||||||||
| Author: | Goel, Ajay|Nagasaka, Takeshi|Arnold, Christian N|Inoue, Toru|Hamilton, Cody|Niedzwiecki, Donna|Compton, Carolyn|Mayer, Robert J|Goldberg, Richard|Bertagnolli, Monica M|Boland, C Richard | ||||||||||
| PMID: | 17087942 | ||||||||||
| 8. | |||||||||||
| Journal: | Hum Pathol. 2007 Apr;38(4):585-92. Epub 2007 Jan 19. | ||||||||||
| Title: | Cytoplasmic localization of p27 (cyclin-dependent kinase inhibitor 1B/KIP1) in colorectal cancer: inverse correlations with nuclear p27 loss, microsatellite instability, and CpG island methylator phenotype. | ||||||||||
| Author: | Ogino, Shuji|Kawasaki, Takako|Ogawa, Akiyo|Kirkner, Gregory J|Loda, Massimo|Fuchs, Charles S | ||||||||||
| PMID: | 17239930 | ||||||||||
| 9. | |||||||||||
| Journal: | Hum Pathol. 2007 Apr;38(4):614-20. Epub 2007 Jan 31. | ||||||||||
| Title: | TGFBR2 mutation is correlated with CpG island methylator phenotype in microsatellite instability-high colorectal cancer. | ||||||||||
| Author: | Ogino, Shuji|Kawasaki, Takako|Ogawa, Akiyo|Kirkner, Gregory J|Loda, Massimo|Fuchs, Charles S | ||||||||||
| PMID: | 17270239 | ||||||||||
| 10. | |||||||||||
| Journal: | Gut. 2007 Nov;56(11):1564-71. Epub 2007 Mar 5. | ||||||||||
| Title: | Molecular correlates with MGMT promoter methylation and silencing support CpG island methylator phenotype-low (CIMP-low) in colorectal cancer. | ||||||||||
| Author: | Ogino, Shuji|Kawasaki, Takako|Kirkner, Gregory J|Suemoto, Yuko|Meyerhardt, Jeffrey A|Fuchs, Charles S | ||||||||||
| PMID: | 17339237 | ||||||||||
| 11. | |||||||||||
| Journal: | Hum Pathol. 2007 Jun;38(6):842-9. Epub 2007 Mar 12. | ||||||||||
| Title: | Fatty acid synthase overexpression in colorectal cancer is associated with microsatellite instability, independent of CpG island methylator phenotype. | ||||||||||
| Author: | Ogino, Shuji|Kawasaki, Takako|Ogawa, Akiyo|Kirkner, Gregory J|Loda, Massimo|Fuchs, Charles S | ||||||||||
| PMID: | 17350669 | ||||||||||
| 12. | |||||||||||
| Journal: | Virchows Arch. 2007 May;450(5):529-37. Epub 2007 Mar 20. | ||||||||||
| Title: | CpG island methylation, response to combination chemotherapy, and patient survival in advanced microsatellite stable colorectal carcinoma. | ||||||||||
| Author: | Ogino, Shuji|Meyerhardt, Jeffrey A|Kawasaki, Takako|Clark, Jeffrey W|Ryan, David P|Kulke, Matthew H|Enzinger, Peter C|Wolpin, Brian M|Loda, Massimo|Fuchs, Charles S | ||||||||||
| PMID: | 17372756 | ||||||||||
| 13. | |||||||||||
| Journal: | BMC Cancer. 2007 May 2;7:72. | ||||||||||
| Title: | 18q loss of heterozygosity in microsatellite stable colorectal cancer is correlated with CpG island methylator phenotype-negative (CIMP-0) and inversely with CIMP-low and CIMP-high. | ||||||||||
| Author: | Ogino, Shuji|Kawasaki, Takako|Kirkner, Gregory J|Ohnishi, Mutsuko|Fuchs, Charles S | ||||||||||
| PMID: | 17474983 | ||||||||||
| 14. | |||||||||||
| Journal: | J Mol Diagn. 2007 Jul;9(3):305-14. | ||||||||||
| Title: | Evaluation of markers for CpG island methylator phenotype (CIMP) in colorectal cancer by a large population-based sample. | ||||||||||
| Author: | Ogino, Shuji|Kawasaki, Takako|Kirkner, Gregory J|Kraft, Peter|Loda, Massimo|Fuchs, Charles S | ||||||||||
| PMID: | 17591929 | ||||||||||
| 15. | |||||||||||
| Journal: | Carcinogenesis. 2007 Sep;28(9):1985-90. Epub 2007 Jul 9. | ||||||||||
| Title: | MGMT germline polymorphism is associated with somatic MGMT promoter methylation and gene silencing in colorectal cancer. | ||||||||||
| Author: | Ogino, Shuji|Hazra, Aditi|Tranah, Gregory J|Kirkner, Gregory J|Kawasaki, Takako|Nosho, Katsuhiko|Ohnishi, Mutsuko|Suemoto, Yuko|Meyerhardt, Jeffrey A|Hunter, David J|Fuchs, Charles S | ||||||||||
| PMID: | 17621591 | ||||||||||
| 16. | |||||||||||
| Journal: | Neoplasia. 2007 Jul;9(7):569-77. | ||||||||||
| Title: | Correlation of beta-catenin localization with cyclooxygenase-2 expression and CpG island methylator phenotype (CIMP) in colorectal cancer. | ||||||||||
| Author: | Kawasaki, Takako|Nosho, Katsuhiko|Ohnishi, Mutsuko|Suemoto, Yuko|Kirkner, Gregory J|Dehari, Reiko|Meyerhardt, Jeffrey A|Fuchs, Charles S|Ogino, Shuji | ||||||||||
| PMID: | 17710160 | ||||||||||
| 17. | |||||||||||
| Journal: | Invest Ophthalmol Vis Sci. 2007 Oct;48(10):4403-6. | ||||||||||
| Title: | Promoter methylation status of multiple genes in uveal melanoma. | ||||||||||
| Author: | Merhavi, Efrat|Cohen, Yoram|Avraham, Bat Chen R|Frenkel, Shahar|Chowers, Itay|Pe'er, Jacob|Goldenberg-Cohen, Nitza | ||||||||||
| PMID: | 17898258 | ||||||||||
| 18. | |||||||||||
| Journal: | Neoplasia. 2007 Dec;9(12):1091-8. | ||||||||||
| Title: | IGFBP3 promoter methylation in colorectal cancer: relationship with microsatellite instability, CpG island methylator phenotype, and p53. | ||||||||||
| Author: | Kawasaki, Takako|Nosho, Katsuhiko|Ohnishi, Mutsuko|Suemoto, Yuko|Kirkner, Gregory J|Fuchs, Charles S|Ogino, Shuji | ||||||||||
| PMID: | 18084616 | ||||||||||
| 19. | |||||||||||
| Journal: | Mod Pathol. 2008 Feb;21(2):150-8. Epub 2007 Dec 14. | ||||||||||
| Title: | WRN promoter methylation possibly connects mucinous differentiation, microsatellite instability and CpG island methylator phenotype in colorectal cancer. | ||||||||||
| Author: | Kawasaki, Takako|Ohnishi, Mutsuko|Suemoto, Yuko|Kirkner, Gregory J|Liu, Zhiqian|Yamamoto, Hiroyuki|Loda, Massimo|Fuchs, Charles S|Ogino, Shuji | ||||||||||
| PMID: | 18084250 | ||||||||||
| 20. | |||||||||||
| Journal: | Mod Pathol. 2008 Mar;21(3):245-55. | ||||||||||
| Title: | CpG island methylator phenotype-low (CIMP-low) colorectal cancer shows not only few methylated CIMP-high-specific CpG islands, but also low-level methylation at individual loci. | ||||||||||
| Author: | Kawasaki, Takako|Ohnishi, Mutsuko|Nosho, Katsuhiko|Suemoto, Yuko|Kirkner, Gregory J|Meyerhardt, Jeffrey A|Fuchs, Charles S|Ogino, Shuji | ||||||||||
| PMID: | 18204436 | ||||||||||
| 21. | |||||||||||
| Journal: | Int J Cancer. 2008 Jun 15;122(12):2767-73. | ||||||||||
| Title: | LINE-1 hypomethylation is inversely associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer. | ||||||||||
| Author: | Ogino, Shuji|Kawasaki, Takako|Nosho, Katsuhiko|Ohnishi, Mutsuko|Suemoto, Yuko|Kirkner, Gregory J|Fuchs, Charles S | ||||||||||
| PMID: | 18366060 | ||||||||||
| 22. | |||||||||||
| Journal: | Neoplasia. 2008 Jun;10(6):534-41. | ||||||||||
| Title: | PIK3CA mutation in colorectal cancer: relationship with genetic and epigenetic alterations. | ||||||||||
| Author: | Nosho, Katsuhiko|Kawasaki, Takako|Ohnishi, Mutsuko|Suemoto, Yuko|Kirkner, Gregory J|Zepf, Dimity|Yan, Liying|Longtine, Janina A|Fuchs, Charles S|Ogino, Shuji | ||||||||||
| PMID: | 18516290 | ||||||||||
| 23. | |||||||||||
| Journal: | PLoS Genet. 2008 Jun 13;4(6):e1000092. | ||||||||||
| Title: | Novel roles for MLH3 deficiency and TLE6-like amplification in DNA mismatch repair-deficient gastrointestinal tumorigenesis and progression. | ||||||||||
| Author: | Chen, Peng-Chieh|Kuraguchi, Mari|Velasquez, John|Wang, Yuxun|Yang, Kan|Edwards, Robert|Gillen, Dan|Edelmann, Winfried|Kucherlapati, Raju|Lipkin, Steven M | ||||||||||
| PMID: | 18551179 | ||||||||||
| 24. | |||||||||||
| Journal: | Cancer Epidemiol Biomarkers Prev. 2008 Jul;17(7):1774-80. | ||||||||||
| Title: | Ethnicity and risk for colorectal cancers showing somatic BRAF V600E mutation or CpG island methylator phenotype. | ||||||||||
| Author: | English, Dallas R|Young, Joanne P|Simpson, Julie A|Jenkins, Mark A|Southey, Melissa C|Walsh, Michael D|Buchanan, Daniel D|Barker, Melissa A|Haydon, Andrew M|Royce, Simon G|Roberts, Aedan|Parry, Susan|Hopper, John L|Jass, Jeremy J|Giles, Graham G | ||||||||||
| PMID: | 18628431 | ||||||||||
| 25. | |||||||||||
| Journal: | Cancer Cell. 2008 Sep 9;14(3):226-37. | ||||||||||
| Title: | RUNX3 attenuates beta-catenin/T cell factors in intestinal tumorigenesis. | ||||||||||
| Author: | Ito, Kosei|Lim, Anthony Chee-Beng|Salto-Tellez, Manuel|Motoda, Lena|Osato, Motomi|Chuang, Linda Shyue Huey|Lee, Cecilia Wei Lin|Voon, Dominic Chih-Cheng|Koo, Jason Kin Wai|Wang, Huajing|Fukamachi, Hiroshi|Ito, Yoshiaki | ||||||||||
| PMID: | 18772112 | ||||||||||
| 26. | |||||||||||
| Journal: | Arch Pathol Lab Med. 2008 Oct;132(10):1657-65. | ||||||||||
| Title: | CpG island methylator phenotype in colorectal cancers: comparison of the new and classic CpG island methylator phenotype marker panels. | ||||||||||
| Author: | Lee, Sun|Cho, Nam-Yun|Yoo, Eun Joo|Kim, Jung Ho|Kang, Gyeong Hoon | ||||||||||
| PMID: | 18834226 | ||||||||||
| 27. | |||||||||||
| Journal: | Int J Oncol. 2008 Nov;33(5):979-84. | ||||||||||
| Title: | Inhibition of the growth and metastasis of human colon cancer by restoration of RUNX3 expression in cancer cells. | ||||||||||
| Author: | Peng, Zhihai|Tang, Huamei|Wang, Xiaoliang|Zhou, Chongzhi|Fan, Junwei|Wang, Liwei|Jia, Zhiliang|Li, Qiang|Le, Xiangdong|Wei, Daoyan|Xie, Keping | ||||||||||
| PMID: | 18949360 | ||||||||||
| 28. | |||||||||||
| Journal: | Histopathology. 2008 Nov;53(5):588-98. | ||||||||||
| Title: | Cyclin D1 is frequently overexpressed in microsatellite unstable colorectal cancer, independent of CpG island methylator phenotype. | ||||||||||
| Author: | Nosho, K|Kawasaki, T|Chan, A T|Ohnishi, M|Suemoto, Y|Kirkner, G J|Fuchs, C S|Ogino, S | ||||||||||
| PMID: | 18983468 | ||||||||||
| 29. | |||||||||||
| Journal: | PLoS One. 2008;3(11):e3698. | ||||||||||
| Title: | Comprehensive biostatistical analysis of CpG island methylator phenotype in colorectal cancer using a large population-based sample. | ||||||||||
| Author: | Nosho, Katsuhiko|Irahara, Natsumi|Shima, Kaori|Kure, Shoko|Kirkner, Gregory J|Schernhammer, Eva S|Hazra, Aditi|Hunter, David J|Quackenbush, John|Spiegelman, Donna|Giovannucci, Edward L|Fuchs, Charles S|Ogino, Shuji | ||||||||||
| PMID: | 19002263 | ||||||||||
| 30. | |||||||||||
| Journal: | Mol Cancer. 2008 Dec 31;7:94. | ||||||||||
| Title: | Gene methylation profiles of normal mucosa, and benign and malignant colorectal tumors identify early onset markers. | ||||||||||
| Author: | Ahlquist, Terje|Lind, Guro E|Costa, Vera L|Meling, Gunn I|Vatn, Morten|Hoff, Geir S|Rognum, Torleiv O|Skotheim, Rolf I|Thiis-Evensen, Espen|Lothe, Ragnhild A | ||||||||||
| PMID: | 19117505 | ||||||||||
| 31. | |||||||||||
| Journal: | Gut. 2009 Jan;58(1):90-6. | ||||||||||
| Title: | CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer. | ||||||||||
| Author: | Ogino, Shuji|Nosho, Katsuhiko|Kirkner, Gregory J|Kawasaki, Takako|Meyerhardt, Jeffrey A|Loda, Massimo|Giovannucci, Edward L|Fuchs, Charles S | ||||||||||
| PMID: | 18832519 | ||||||||||
| 32. | |||||||||||
| Journal: | Biomed Pharmacother. 2009 Aug;63(7):492-500. | ||||||||||
| Title: | 5-Aza-2'-deoxycytidine reactivates expression of RUNX3 by deletion of DNA methyltransferases leading to caspase independent apoptosis in colorectal cancer Lovo cells. | ||||||||||
| Author: | Deng, Tao|Zhang, Yan | ||||||||||
| PMID: | 18848767 | ||||||||||
| 33. | |||||||||||
| Journal: | Neoplasia. 2009 Jan;11(1):87-95. | ||||||||||
| Title: | JC virus T-antigen in colorectal cancer is associated with p53 expression and chromosomal instability, independent of CpG island methylator phenotype. | ||||||||||
| Author: | Nosho, Katsuhiko|Shima, Kaori|Kure, Shoko|Irahara, Natsumi|Baba, Yoshifumi|Chen, Li|Kirkner, Gregory J|Fuchs, Charles S|Ogino, Shuji | ||||||||||
| PMID: | 19107235 | ||||||||||
| 34. | |||||||||||
| Journal: | Am J Gastroenterol. 2009 Feb;104(2):426-36. | ||||||||||
| Title: | RUNX3 inactivation in colorectal polyps arising through different pathways of colonic carcinogenesis. | ||||||||||
| Author: | Subramaniam, Manish M|Chan, Jason Y|Soong, Richie|Ito, Kosei|Yeoh, Khay G|Wong, Reuben|Guenther, Thomas|Will, Olivia|Chen, Chee L|Kumarasinghe, Marian P|Ito, Yoshiaki|Salto-Tellez, Manuel | ||||||||||
| PMID: | 19174785 | ||||||||||
| 35. | |||||||||||
| Journal: | Br J Cancer. 2009 Mar 10;100(5):676-9. | ||||||||||
| Title: | The expression of RUNX3 in colorectal cancer is associated with disease stage and patient outcome. | ||||||||||
| Author: | Soong, R|Shah, N|Peh, B K|Chong, P Y|Ng, S S|Zeps, N|Joseph, D|Salto-Tellez, M|Iacopetta, B|Ito, Y | ||||||||||
| PMID: | 19223906 | ||||||||||
| 36. | |||||||||||
| Journal: | Mod Pathol. 2009 Jul;22(7):922-32. | ||||||||||
| Title: | SIRT1 histone deacetylase expression is associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer. | ||||||||||
| Author: | Nosho, Katsuhiko|Shima, Kaori|Irahara, Natsumi|Kure, Shoko|Firestein, Ron|Baba, Yoshifumi|Toyoda, Saori|Chen, Li|Hazra, Aditi|Giovannucci, Edward L|Fuchs, Charles S|Ogino, Shuji | ||||||||||
| PMID: | 19430421 | ||||||||||
| 37. | |||||||||||
| Journal: | Clin Cancer Res. 2009 Jun 1;15(11):3663-71. | ||||||||||
| Title: | DNMT3B expression might contribute to CpG island methylator phenotype in colorectal cancer. | ||||||||||
| Author: | Nosho, Katsuhiko|Shima, Kaori|Irahara, Natsumi|Kure, Shoko|Baba, Yoshifumi|Kirkner, Gregory J|Chen, Li|Gokhale, Sumita|Hazra, Aditi|Spiegelman, Donna|Giovannucci, Edward L|Jaenisch, Rudolf|Fuchs, Charles S|Ogino, Shuji | ||||||||||
| PMID: | 19470733 | ||||||||||
| 38. | |||||||||||
| Journal: | Pathobiology. 2009;76(4):163-9. | ||||||||||
| Title: | RUNX3 inhibits cell proliferation and induces apoptosis by TGF-beta-dependent and -independent mechanisms in human colon carcinoma cells. | ||||||||||
| Author: | Tong, Dan-Dan|Jiang, Ying|Li, Ming|Kong, Dan|Meng, Xiang-Nin|Zhao, Yu-Zhen|Jin, Yan|Bai, Jing|Fu, Song-Bin|Geng, Jing-Shu | ||||||||||
| PMID: | 19571605 | ||||||||||
| 39. | |||||||||||
| Journal: | Biochim Biophys Acta. 2009 Dec;1796(2):315-31. | ||||||||||
| Title: | Molecular pathology of RUNX3 in human carcinogenesis. | ||||||||||
| Author: | Subramaniam, Manish Mani|Chan, Jason Yongsheng|Yeoh, Khay Guan|Quek, Timothy|Ito, Kosei|Salto-Tellez, Manuel | ||||||||||
| PMID: | 19682550 | ||||||||||
| 40. | |||||||||||
| Journal: | Gastroenterology. 2009 Nov;137(5):1609-20.e1-3. | ||||||||||
| Title: | A prospective cohort study shows unique epigenetic, genetic, and prognostic features of synchronous colorectal cancers. | ||||||||||
| Author: | Nosho, Katsuhiko|Kure, Shoko|Irahara, Natsumi|Shima, Kaori|Baba, Yoshifumi|Spiegelman, Donna|Meyerhardt, Jeffrey A|Giovannucci, Edward L|Fuchs, Charles S|Ogino, Shuji | ||||||||||
| PMID: | 19686742 | ||||||||||
| 41. | |||||||||||
| Journal: | Cancer Epidemiol Biomarkers Prev. 2009 Oct;18(10):2765-72. | ||||||||||
| Title: | Vitamin D receptor expression is associated with PIK3CA and KRAS mutations in colorectal cancer. | ||||||||||
| Author: | Kure, Shoko|Nosho, Katsuhiko|Baba, Yoshifumi|Irahara, Natsumi|Shima, Kaori|Ng, Kimmie|Meyerhardt, Jeffrey A|Giovannucci, Edward L|Fuchs, Charles S|Ogino, Shuji | ||||||||||
| PMID: | 19789368 | ||||||||||
| 42. | |||||||||||
| Journal: | Clin Cancer Res. 2009 Oct 15;15(20):6412-20. | ||||||||||
| Title: | Lymphocytic reaction to colorectal cancer is associated with longer survival, independent of lymph node count, microsatellite instability, and CpG island methylator phenotype. | ||||||||||
| Author: | Ogino, Shuji|Nosho, Katsuhiko|Irahara, Natsumi|Meyerhardt, Jeffrey A|Baba, Yoshifumi|Shima, Kaori|Glickman, Jonathan N|Ferrone, Cristina R|Mino-Kenudson, Mari|Tanaka, Noriko|Dranoff, Glenn|Giovannucci, Edward L|Fuchs, Charles S | ||||||||||
| PMID: | 19825961 | ||||||||||
| 43. | |||||||||||
| Journal: | Oncol Rep. 2010 Jan;23(1):191-7. | ||||||||||
| Title: | CpG island methylation of BNIP3 predicts resistance against S-1/CPT-11 combined therapy in colorectal cancer patients. | ||||||||||
| Author: | Hiraki, Masatsugu|Kitajima, Yoshihiko|Nakafusa, Yuji|Nakamura, Jun|Hashiguchi, Kazuyoshi|Sumi, Kenji|Noshiro, Hirokazu|Miyazaki, Kohji | ||||||||||
| PMID: | 19956881 | ||||||||||
| 44. | |||||||||||
| Journal: | Gastroenterology. 2010 May;138(5):1854-62. | ||||||||||
| Title: | Aberrant DNA methylation in hereditary nonpolyposis colorectal cancer without mismatch repair deficiency. | ||||||||||
| Author: | Goel, Ajay|Xicola, Rosa M|Nguyen, Thuy-Phuong|Doyle, Brian J|Sohn, Vanessa R|Bandipalliam, Prathap|Rozek, Laura S|Reyes, Josep|Cordero, Carmen|Balaguer, Francesc|Castells, Antoni|Jover, Rodrigo|Andreu, Montserrat|Syngal, Sapna|Boland, C Richard|Llor, Xavi | ||||||||||
| PMID: | 20102720 | ||||||||||
| 45. | |||||||||||
| Journal: | Am J Gastroenterol. 2010 Jul;105(7):1610-9. | ||||||||||
| Title: | Methylation status of genes in non-neoplastic mucosa from patients with ulcerative colitis-associated colorectal cancer. | ||||||||||
| Author: | Garrity-Park, Megan M|Loftus, Edward V Jr|Sandborn, William J|Bryant, Sandra C|Smyrk, Thomas C | ||||||||||
| PMID: | 20160714 | ||||||||||
| 46. | |||||||||||
| Journal: | Cancer Epidemiol Biomarkers Prev. 2010 Mar;19(3):822-31. | ||||||||||
| Title: | PTGER2 overexpression in colorectal cancer is associated with microsatellite instability, independent of CpG island methylator phenotype. | ||||||||||
| Author: | Baba, Yoshifumi|Nosho, Katsuhiko|Shima, Kaori|Goessling, Wolfram|Chan, Andrew T|Ng, Kimmie|Chan, Jennifer A|Giovannucci, Edward L|Fuchs, Charles S|Ogino, Shuji | ||||||||||
| PMID: | 20200425 | ||||||||||
| 47. | |||||||||||
| Journal: | Cancer Epidemiol. 2010 Jun;34(3):338-44. | ||||||||||
| Title: | Polymorphisms in methyl-group metabolism genes and risk of sporadic colorectal cancer with relation to the CpG island methylator phenotype. | ||||||||||
| Author: | Karpinski, Pawel|Myszka, Aleksander|Ramsey, David|Misiak, Blazej|Gil, Justyna|Laczmanska, Izabela|Grzebieniak, Zygmunt|Sebzda, Tadeusz|Smigiel, Robert|Stembalska, Agnieszka|Sasiadek, Maria M | ||||||||||
| PMID: | 20381446 | ||||||||||
| 48. | |||||||||||
| Journal: | Cancer Res. 2010 May 15;70(10):4243-52. | ||||||||||
| Title: | Role of RUNX3 in bone morphogenetic protein signaling in colorectal cancer. | ||||||||||
| Author: | Lee, Cecilia Wei Lin|Ito, Kosei|Ito, Yoshiaki | ||||||||||
| PMID: | 20442291 | ||||||||||
| 49. | |||||||||||
| Journal: | Carcinogenesis. 2010 Sep;31(9):1567-75. | ||||||||||
| Title: | The role of EZH2 and DNA methylation in the silencing of the tumour suppressor RUNX3 in colorectal cancer. | ||||||||||
| Author: | Kodach, Liudmila L|Jacobs, Rutger J|Heijmans, Jarom|van Noesel, Carel J M|Langers, Alexandra M J|Verspaget, Hein W|Hommes, Daniel W|Offerhaus, G Johan A|van den Brink, Gijs R|Hardwick, James C H | ||||||||||
| PMID: | 20631058 | ||||||||||
| 50. | |||||||||||
| Journal: | Anticancer Res. 2010 Jul;30(7):2673-82. | ||||||||||
| Title: | RUNX3 promoter methylation in colorectal cancer: its relationship with microsatellite instability and its suitability as a novel serum tumor marker. | ||||||||||
| Author: | Nishio, Minoru|Sakakura, Chouhei|Nagata, Tomoyuki|Komiyama, Sosuke|Miyashita, Atsushi|Hamada, Takuo|Kuryu, Yoshiaki|Ikoma, Hisashi|Kubota, Takeshi|Kimura, Akio|Nakanishi, Masayoshi|Ichikawa, Daisuke|Fujiwara, Hitoshi|Okamoto, Kazuma|Ochiai, Toshiya|Kokuba | ||||||||||
| PMID: | 20682997 | ||||||||||
| 51. | |||||||||||
| Journal: | Am J Pathol. 2010 Dec;177(6):2731-40. | ||||||||||
| Title: | Novel application of structural equation modeling to correlation structure analysis of CpG island methylation in colorectal cancer. | ||||||||||
| Author: | Tanaka, Noriko|Huttenhower, Curtis|Nosho, Katsuhiko|Baba, Yoshifumi|Shima, Kaori|Quackenbush, John|Haigis, Kevin M|Giovannucci, Edward|Fuchs, Charles S|Ogino, Shuji | ||||||||||
| PMID: | 21037082 | ||||||||||
| 52. | |||||||||||
| Journal: | Anticancer Res. 2010 Dec;30(12):4811-8. | ||||||||||
| Title: | Aberrant methylation of heparan sulfate glucosamine 3-O-sulfotransferase 2 genes as a biomarker in colorectal cancer. | ||||||||||
| Author: | Tokuyama, Yasuharu|Takahashi, Takao|Okumura, Naoki|Nonaka, Kenichi|Kawaguchi, Yoshihiro|Yamaguchi, Kazuya|Osada, Shinji|Gazdar, Adi|Yoshida, Kazuhiro | ||||||||||
| PMID: | 21187457 | ||||||||||
| 53. | |||||||||||
| Journal: | Int J Cancer. 2011 Mar 1;128(5):1080-94. | ||||||||||
| Title: | Prognostic significance of CDKN2A (p16) promoter methylation and loss of expression in 902 colorectal cancers: Cohort study and literature review. | ||||||||||
| Author: | Shima, Kaori|Nosho, Katsuhiko|Baba, Yoshifumi|Cantor, Mami|Meyerhardt, Jeffrey A|Giovannucci, Edward L|Fuchs, Charles S|Ogino, Shuji | ||||||||||
| PMID: | 20473920 | ||||||||||
| 54. | |||||||||||
| Journal: | Gut. 2011 Apr;60(4):499-508. | ||||||||||
| Title: | Sequential DNA methylation changes are associated with DNMT3B overexpression in colorectal neoplastic progression. | ||||||||||
| Author: | Ibrahim, Ashraf E K|Arends, Mark J|Silva, Ana-Luisa|Wyllie, Andrew H|Greger, Liliana|Ito, Yoko|Vowler, Sarah L|Huang, Tim H-M|Tavare, Simon|Murrell, Adele|Brenton, James D | ||||||||||
| PMID: | 21068132 | ||||||||||
| 55. | |||||||||||
| Journal: | Carcinogenesis. 2011 Mar;32(3):318-26. | ||||||||||
| Title: | Associations between genetic variation in RUNX1, RUNX2, RUNX3, MAPK1 and eIF4E and riskof colon and rectal cancer: additional support for a TGF-beta-signaling pathway. | ||||||||||
| Author: | Slattery, Martha L|Lundgreen, Abbie|Herrick, Jennifer S|Caan, Bette J|Potter, John D|Wolff, Roger K | ||||||||||
| PMID: | 21088106 | ||||||||||
| 56. | |||||||||||
| Journal: | Int J Oncol. 2011 Jan;38(1):201-7. | ||||||||||
| Title: | RUNX3 copy number predicts the development of UC-associated colorectal cancer. | ||||||||||
| Author: | Watanabe, Toshiaki|Kobunai, Takashi|Ikeuchi, Hiroki|Yamamoto, Yoko|Matsuda, Keiji|Ishihara, Soichiro|Nozawa, Keijiro|Iinuma, Hisae|Kanazawa, Takamitsu|Tanaka, Toshiaki|Yokoyama, Tadashi|Konishi, Tsuyoshi|Eshima, Kiyoshi|Ajioka, Yoichi|Hibi, Toshifumi|Wata | ||||||||||
| PMID: | 21109941 | ||||||||||
| 57. | |||||||||||
| Journal: | Cancer Causes Control. 2011 Feb;22(2):301-9. | ||||||||||
| Title: | MGMT promoter methylation, loss of expression and prognosis in 855 colorectal cancers. | ||||||||||
| Author: | Shima, Kaori|Morikawa, Teppei|Baba, Yoshifumi|Nosho, Katsuhiko|Suzuki, Maiko|Yamauchi, Mai|Hayashi, Marika|Giovannucci, Edward|Fuchs, Charles S|Ogino, Shuji | ||||||||||
| PMID: | 21140203 | ||||||||||
| 58. | |||||||||||
| Journal: | Gastroenterology. 2011 Apr;140(4):1174-81. | ||||||||||
| Title: | 5-Fluorouracil adjuvant chemotherapy does not increase survival in patients with CpG island methylator phenotype colorectal cancer. | ||||||||||
| Author: | Jover, Rodrigo|Nguyen, Thuy-Phuong|Perez-Carbonell, Lucia|Zapater, Pedro|Paya, Artemio|Alenda, Cristina|Rojas, Estefania|Cubiella, Joaquin|Balaguer, Francesc|Morillas, Juan D|Clofent, Juan|Bujanda, Luis|Rene, Josep M|Bessa, Xavier|Xicola, Rosa M|Nicolas-P | ||||||||||
| PMID: | 21185836 | ||||||||||
| 59. | |||||||||||
| Journal: | Cancer. 2011 Sep 15;117(18):4175-83. | ||||||||||
| Title: | Genetic variation in the transforming growth factor-beta signaling pathway and survival after diagnosis with colon and rectal cancer. | ||||||||||
| Author: | Slattery, Martha L|Lundgreen, Abbie|Herrick, Jennifer S|Wolff, Roger K|Caan, Bette J | ||||||||||
| PMID: | 21365634 | ||||||||||
| 60. | |||||||||||
| Journal: | J Immunol. 2011 Jun 1;186(11):6515-20. | ||||||||||
| Title: | Runx3 is required for full activation of regulatory T cells to prevent colitis-associated tumor formation. | ||||||||||
| Author: | Sugai, Manabu|Aoki, Koji|Osato, Motomi|Nambu, Yukiko|Ito, Kosei|Taketo, Makoto M|Shimizu, Akira | ||||||||||
| PMID: | 21515792 | ||||||||||
| 61. | |||||||||||
| Journal: | Tumour Biol. 2011 Aug;32(4):653-9. | ||||||||||
| Title: | Detection of viral DNA sequences in sporadic colorectal cancers in relation to CpG island methylation and methylator phenotype. | ||||||||||
| Author: | Karpinski, Pawel|Myszka, Aleksander|Ramsey, David|Kielan, Wojciech|Sasiadek, Maria Malgorzata | ||||||||||
| PMID: | 21625944 | ||||||||||
| 62. | |||||||||||
| Journal: | PLoS One. 2011;6(6):e21102. | ||||||||||
| Title: | B vitamins, methionine and alcohol intake and risk of colon cancer in relation to BRAF mutation and CpG island methylator phenotype (CIMP). | ||||||||||
| Author: | Schernhammer, Eva S|Giovannucci, Edward|Baba, Yoshifumi|Fuchs, Charles S|Ogino, Shuji | ||||||||||
| PMID: | 21738611 | ||||||||||
| 63. | |||||||||||
| Journal: | Clin Colorectal Cancer. 2011 Jun;10(2):134-41. | ||||||||||
| Title: | Predicting ulcerative colitis-associated colorectal cancer using reverse-transcription polymerase chain reaction analysis. | ||||||||||
| Author: | Watanabe, Toshiaki|Kobunai, Takashi|Yamamoto, Yoko|Ikeuchi, Hiroki|Matsuda, Keiji|Ishihara, Soichiro|Nozawa, Keijiro|Iinuma, Hisae|Kanazawa, Takamitsu|Tanaka, Toshiaki|Yokoyama, Tadashi|Konishi, Tsuyoshi|Eshima, Kiyoshi|Ajioka, Yohichi|Hibi, Toshifumi|Wat | ||||||||||
| PMID: | 21859567 | ||||||||||
| 64. | |||||||||||
| Journal: | Hepatogastroenterology. 2011 Nov-Dec;58(112):2007-11. | ||||||||||
| Title: | Analysis of the RUNX3 gene methylation in serum DNA from esophagus squamous cell carcinoma, gastric and colorectal adenocarcinoma patients. | ||||||||||
| Author: | Zheng, Yun|Zhang, Youwei|Huang, Xiang|Chen, Longbang | ||||||||||
| PMID: | 22234069 | ||||||||||
| 65. | |||||||||||
| Journal: | Inflamm Bowel Dis. 2012 Feb;18(2):275-83. | ||||||||||
| Title: | Myeloperoxidase immunohistochemistry as a measure of disease activity in ulcerative colitis: association with ulcerative colitis-colorectal cancer, tumor necrosis factor polymorphism and RUNX3 methylation. | ||||||||||
| Author: | Garrity-Park, Megan|Loftus, Edward V Jr|Sandborn, William J|Smyrk, Thomas C | ||||||||||
| PMID: | 21425209 | ||||||||||
| 66. | |||||||||||
| Journal: | J Cell Physiol. 2012 Feb;227(2):839-49. | ||||||||||
| Title: | Identification of RUNX3 as a component of the MST/Hpo signaling pathway. | ||||||||||
| Author: | Min, Boram|Kim, Min-Kyu|Zhang, Joo-Won|Kim, Jiyeon|Chung, Kwang-Chul|Oh, Byung-Chul|Stein, Gary S|Lee, Yong-Hee|van Wijnen, Andre J|Bae, Suk-Chul | ||||||||||
| PMID: | 21678419 | ||||||||||
| 67. | |||||||||||
| Journal: | Int J Surg Pathol. 2012 Apr;20(2):185-90. | ||||||||||
| Title: | Rhabdoid carcinoma of the colon: a distinct entity with a very aggressive behavior: a case report associated with a polyposis coli and review of the literature. | ||||||||||
| Author: | Remo, Andrea|Zanella, Caterina|Molinari, Enrico|Talamini, Alberto|Tollini, Filippo|Piacentini, Paolo|Battaglia, Paolo|Baritono, Elisabetta|Bonetti, Andrea|Lanza, Franco|Fasolin, Antonio|Manfrin, Erminia|Vendraminelli, Roberto | ||||||||||
| PMID: | 21791485 | ||||||||||
| 68. | |||||||||||
| Journal: | Pathol Oncol Res. 2012 Apr;18(2):263-70. | ||||||||||
| Title: | CDH13 and FLBN3 gene methylation are associated with poor prognosis in colorectal cancer. | ||||||||||
| Author: | Wang, Zhu|Yuan, Xin|Jiao, Nanlin|Zhu, Hui|Zhang, Youwei|Tong, Jiandong | ||||||||||
| PMID: | 21796503 | ||||||||||
| 69. | |||||||||||
| Journal: | Surgery. 2012 Apr;151(4):564-70. | ||||||||||
| Title: | CpG island methylator phenotype infers a poor disease-free survival in locally advanced rectal cancer. | ||||||||||
| Author: | Jo, Peter|Jung, Klaus|Grade, Marian|Conradi, Lena-Christin|Wolff, Hendrik A|Kitz, Julia|Becker, Heinz|Ruschoff, Josef|Hartmann, Arndt|Beissbarth, Tim|Muller-Dornieden, Annegret|Ghadimi, Michael|Schneider-Stock, Regine|Gaedcke, Jochen | ||||||||||
| PMID: | 22001634 | ||||||||||
| 70. | |||||||||||
| Journal: | Tumour Biol. 2012 Apr;33(2):403-12. | ||||||||||
| Title: | Epigenetic changes induced by oxidative stress in colorectal cancer cells: methylation of tumor suppressor RUNX3. | ||||||||||
| Author: | Kang, Kyoung Ah|Zhang, Rui|Kim, Gi Young|Bae, Suk Chul|Hyun, Jin Won | ||||||||||
| PMID: | 22274925 | ||||||||||
| 71. | |||||||||||
| Journal: | Int J Cancer. 2013 May 1;132(9):2209-16. | ||||||||||
| Title: | Methylation and microsatellite status and recurrence following adjuvant FOLFOX in colorectal cancer. | ||||||||||
| Author: | Han, Sae-Won|Lee, Hyun-Jung|Bae, Jeong Mo|Cho, Nam-Yun|Lee, Kyung-Hun|Kim, Tae-Yong|Oh, Do-Youn|Im, Seock-Ah|Bang, Yung-Jue|Jeong, Seung-Yong|Park, Kyu Joo|Park, Jae-Gahb|Kang, Gyeong Hoon|Kim, Tae-You | ||||||||||
| PMID: | 23034738 | ||||||||||
| 72. | |||||||||||
| Journal: | Carcinogenesis. 2013 Feb;34(2):292-8. | ||||||||||
| Title: | Phenotypic and tumor molecular characterization of colorectal cancer in relation to a susceptibility SMAD7 variant associated with survival. | ||||||||||
| Author: | Garcia-Albeniz, Xabier|Nan, Hongmei|Valeri, Linda|Morikawa, Teppei|Kuchiba, Aya|Phipps, Amanda I|Hutter, Carolyn M|Peters, Ulrike|Newcomb, Polly A|Fuchs, Charles S|Giovannucci, Edward L|Ogino, Shuji|Chan, Andrew T | ||||||||||
| PMID: | 23104301 | ||||||||||
| 73. | |||||||||||
| Journal: | Mol Med Rep. 2013 May;7(5):1425-30. | ||||||||||
| Title: | Effects of paeonol on intracellular calcium concentration and expression of RUNX3 in LoVo human colon cancer cells. | ||||||||||
| Author: | Li, Ming|Tan, Shi-Yun|Zhang, Jun|You, Hong-Xia | ||||||||||
| PMID: | 23504038 | ||||||||||
| 74. | |||||||||||
| Journal: | PLoS One. 2013;8(3):e58731. | ||||||||||
| Title: | Somatic mutations, allele loss, and DNA methylation of the Cub and Sushi Multiple Domains 1 (CSMD1) gene reveals association with early age of diagnosis in colorectal cancer patients. | ||||||||||
| Author: | Shull, Austin Y|Clendenning, Megan L|Ghoshal-Gupta, Sampa|Farrell, Christopher L|Vangapandu, Hima V|Dudas, Larry|Wilkerson, Brent J|Buckhaults, Phillip J | ||||||||||
| PMID: | 23505554 | ||||||||||
| 75. | |||||||||||
| Journal: | Int J Oncol. 2013 Jul;43(1):228-36. | ||||||||||
| Title: | The role of a ginseng saponin metabolite as a DNA methyltransferase inhibitor in colorectal cancer cells. | ||||||||||
| Author: | Kang, Kyoung Ah|Kim, Hee Sun|Kim, Dong Hyun|Hyun, Jin Won | ||||||||||
| PMID: | 23652987 | ||||||||||
| 76. | |||||||||||
| Journal: | Int J Oncol. 2013 Nov;43(5):1511-6. | ||||||||||
| Title: | Oxidative stress induces proliferation of colorectal cancer cells by inhibiting RUNX3 and activating the Akt signaling pathway. | ||||||||||
| Author: | Kang, Kyoung Ah|Kim, Ki Cheon|Bae, Suk Chul|Hyun, Jin Won | ||||||||||
| PMID: | 24042352 | ||||||||||
| 77. | |||||||||||
| Journal: | Int J Oncol. 2013 Dec;43(6):1907-14. | ||||||||||
| Title: | Compound K, a metabolite of ginseng saponin, inhibits colorectal cancer cell growth and induces apoptosis through inhibition of histone deacetylase activity. | ||||||||||
| Author: | Kang, Kyoung Ah|Piao, Mei Jing|Kim, Ki Cheon|Zheng, Jian|Yao, Cheng Wen|Cha, Ji Won|Kim, Hye Sun|Kim, Dong Hyun|Bae, Suk Chul|Hyun, Jin Won | ||||||||||
| PMID: | 24100442 | ||||||||||
| 78. | |||||||||||
| Journal: | Oncol Lett. 2013 Dec;6(6):1687-1692. | ||||||||||
| Title: | DNA methylation as an epigenetic biomarker in colorectal cancer. | ||||||||||
| Author: | Silva, Tiago Donizetti|Vidigal, Veronica Marques|Felipe, Aledson Vitor|DE Lima, Jacqueline Miranda|Neto, Ricardo Artigiani|Saad, Sarhan Sidney|Forones, Nora Manoukian | ||||||||||
| PMID: | 24260063 | ||||||||||
| 79. | |||||||||||
| Journal: | Anticancer Res. 2014 Jan;34(1):133-40. | ||||||||||
| Title: | Demethylation of RUNX3 by vincristine in colorectal adenocarcinoma cells. | ||||||||||
| Author: | Moon, Ji Wook|Lee, Soo Kyung|Lee, Jung Ok|Kim, Ji Hae|Kim, Nami|Kim, Jin|Kim, Hyeon Soo|Park, Sun-Hwa | ||||||||||
| PMID: | 24403453 | ||||||||||
| 80. | |||||||||||
| Journal: | PLoS One. 2014 Jan 21;9(1):e86657. | ||||||||||
| Title: | Comparison of CpG island methylator phenotype (CIMP) frequency in colon cancer using different probe- and gene-specific scoring alternatives on recommended multi-gene panels. | ||||||||||
| Author: | Berg, Marianne|Hagland, Hanne R|Soreide, Kjetil | ||||||||||
| PMID: | 24466191 | ||||||||||
| 81. | |||||||||||
| Journal: | Gastroenterology. 2014 Sep;147(3):637-45. | ||||||||||
| Title: | CpG island methylator phenotype is associated with response to adjuvant irinotecan-based therapy for stage III colon cancer. | ||||||||||
| Author: | Shiovitz, Stacey|Bertagnolli, Monica M|Renfro, Lindsay A|Nam, Eunmi|Foster, Nathan R|Dzieciatkowski, Slavomir|Luo, Yanxin|Lao, Victoria Valinluck|Monnat, Raymond J Jr|Emond, Mary J|Maizels, Nancy|Niedzwiecki, Donna|Goldberg, Richard M|Saltz, Leonard B|Ven | ||||||||||
| PMID: | 24859205 | ||||||||||
| 82. | |||||||||||
| Journal: | Onco Targets Ther. 2014 Jul 10;7:1237-45. | ||||||||||
| Title: | Clinical significance and association of RUNX3 hypermethylation frequency with colorectal cancer: a meta-analysis. | ||||||||||
| Author: | Mu, Wei-Ping|Wang, Jian|Niu, Qiong|Shi, Ning|Lian, Hai-Feng | ||||||||||
| PMID: | 25053885 | ||||||||||
| 83. | |||||||||||
| Journal: | Nan Fang Yi Ke Da Xue Xue Bao. 2014 Jun;34(7):1042-7. | ||||||||||
| Title: | |||||||||||