Primary Site >> Colorectal Cancer

Gene >> RUNX3

Journal: Lab Invest. 2004 Apr;84(4):479-84.
Title: Methylation of RUNX3 in various types of human cancers and premalignant stages of gastric carcinoma.
Author: Kim, Tai Young|Lee, Hyeon Joo|Hwang, Kyu Sang|Lee, Minjin|Kim, Jae Won|Bang, Yung-Jue|Kang, Gyeong Hoon
PMID: 14968123
Journal: Oncogene. 2004 Sep 2;23(40):6736-42.
Title: Promoter hypermethylation downregulates RUNX3 gene expression in colorectal cancer cell lines.
Author: Ku, Ja-Lok|Kang, Sung-Bum|Shin, Young-Kyoung|Kang, Hio Chung|Hong, Sung-Hye|Kim, Il-Jin|Shin, Joo-Ho|Han, Inn-Oc|Park, Jae-Gahb
PMID: 15273736
Journal: Int J Cancer. 2004 Dec 10;112(5):754-9.
Title: Epigenetic inactivation of RUNX3 in microsatellite unstable sporadic colon cancers.
Author: Goel, Ajay|Arnold, Christian N|Tassone, Pierfrancesco|Chang, Dong K|Niedzwiecki, Donna|Dowell, Jeannette M|Wasserman, Linda|Compton, Carolyn|Mayer, Robert J|Bertagnolli, Monica M|Boland, C Richard
PMID: 15386381
Journal: Anticancer Res. 2005 Jul-Aug;25(4):2627-30.
Title: RUNX3 promoter region is specifically methylated in poorly-differentiated colorectal cancer.
Author: Imamura, Yasuhiro|Hibi, Kenji|Koike, Masahiko|Fujiwara, Michitaka|Kodera, Yasuhiro|Ito, Katsuki|Nakao, Akimasa
PMID: 16080503
Journal: Anticancer Res. 2006 Jan-Feb;26(1A):55-8.
Title: Lymph node metastasis is infrequent in patients with highly-methylated colorectal cancer.
Author: Hibi, Kenji|Nakao, Akimasa
PMID: 16475679
Journal: Int J Mol Med. 2006 Dec;18(6):1019-23.
Title: Hedgehog signaling pathway and gastrointestinal stem cell signaling network (review).
Author: Katoh, Yuriko|Katoh, Masaru
PMID: 17089004
Journal: Gastroenterology. 2007 Jan;132(1):127-38.
Title: The CpG island methylator phenotype and chromosomal instability are inversely correlated in sporadic colorectal cancer.
Author: Goel, Ajay|Nagasaka, Takeshi|Arnold, Christian N|Inoue, Toru|Hamilton, Cody|Niedzwiecki, Donna|Compton, Carolyn|Mayer, Robert J|Goldberg, Richard|Bertagnolli, Monica M|Boland, C Richard
PMID: 17087942
Journal: Hum Pathol. 2007 Apr;38(4):585-92. Epub 2007 Jan 19.
Title: Cytoplasmic localization of p27 (cyclin-dependent kinase inhibitor 1B/KIP1) in colorectal cancer: inverse correlations with nuclear p27 loss, microsatellite instability, and CpG island methylator phenotype.
Author: Ogino, Shuji|Kawasaki, Takako|Ogawa, Akiyo|Kirkner, Gregory J|Loda, Massimo|Fuchs, Charles S
PMID: 17239930
Journal: Hum Pathol. 2007 Apr;38(4):614-20. Epub 2007 Jan 31.
Title: TGFBR2 mutation is correlated with CpG island methylator phenotype in microsatellite instability-high colorectal cancer.
Author: Ogino, Shuji|Kawasaki, Takako|Ogawa, Akiyo|Kirkner, Gregory J|Loda, Massimo|Fuchs, Charles S
PMID: 17270239
Journal: Gut. 2007 Nov;56(11):1564-71. Epub 2007 Mar 5.
Title: Molecular correlates with MGMT promoter methylation and silencing support CpG island methylator phenotype-low (CIMP-low) in colorectal cancer.
Author: Ogino, Shuji|Kawasaki, Takako|Kirkner, Gregory J|Suemoto, Yuko|Meyerhardt, Jeffrey A|Fuchs, Charles S
PMID: 17339237
Journal: Hum Pathol. 2007 Jun;38(6):842-9. Epub 2007 Mar 12.
Title: Fatty acid synthase overexpression in colorectal cancer is associated with microsatellite instability, independent of CpG island methylator phenotype.
Author: Ogino, Shuji|Kawasaki, Takako|Ogawa, Akiyo|Kirkner, Gregory J|Loda, Massimo|Fuchs, Charles S
PMID: 17350669
Journal: Virchows Arch. 2007 May;450(5):529-37. Epub 2007 Mar 20.
Title: CpG island methylation, response to combination chemotherapy, and patient survival in advanced microsatellite stable colorectal carcinoma.
Author: Ogino, Shuji|Meyerhardt, Jeffrey A|Kawasaki, Takako|Clark, Jeffrey W|Ryan, David P|Kulke, Matthew H|Enzinger, Peter C|Wolpin, Brian M|Loda, Massimo|Fuchs, Charles S
PMID: 17372756
Journal: BMC Cancer. 2007 May 2;7:72.
Title: 18q loss of heterozygosity in microsatellite stable colorectal cancer is correlated with CpG island methylator phenotype-negative (CIMP-0) and inversely with CIMP-low and CIMP-high.
Author: Ogino, Shuji|Kawasaki, Takako|Kirkner, Gregory J|Ohnishi, Mutsuko|Fuchs, Charles S
PMID: 17474983
Journal: J Mol Diagn. 2007 Jul;9(3):305-14.
Title: Evaluation of markers for CpG island methylator phenotype (CIMP) in colorectal cancer by a large population-based sample.
Author: Ogino, Shuji|Kawasaki, Takako|Kirkner, Gregory J|Kraft, Peter|Loda, Massimo|Fuchs, Charles S
PMID: 17591929
Journal: Carcinogenesis. 2007 Sep;28(9):1985-90. Epub 2007 Jul 9.
Title: MGMT germline polymorphism is associated with somatic MGMT promoter methylation and gene silencing in colorectal cancer.
Author: Ogino, Shuji|Hazra, Aditi|Tranah, Gregory J|Kirkner, Gregory J|Kawasaki, Takako|Nosho, Katsuhiko|Ohnishi, Mutsuko|Suemoto, Yuko|Meyerhardt, Jeffrey A|Hunter, David J|Fuchs, Charles S
PMID: 17621591
Journal: Neoplasia. 2007 Jul;9(7):569-77.
Title: Correlation of beta-catenin localization with cyclooxygenase-2 expression and CpG island methylator phenotype (CIMP) in colorectal cancer.
Author: Kawasaki, Takako|Nosho, Katsuhiko|Ohnishi, Mutsuko|Suemoto, Yuko|Kirkner, Gregory J|Dehari, Reiko|Meyerhardt, Jeffrey A|Fuchs, Charles S|Ogino, Shuji
PMID: 17710160
Journal: Invest Ophthalmol Vis Sci. 2007 Oct;48(10):4403-6.
Title: Promoter methylation status of multiple genes in uveal melanoma.
Author: Merhavi, Efrat|Cohen, Yoram|Avraham, Bat Chen R|Frenkel, Shahar|Chowers, Itay|Pe'er, Jacob|Goldenberg-Cohen, Nitza
PMID: 17898258
Journal: Neoplasia. 2007 Dec;9(12):1091-8.
Title: IGFBP3 promoter methylation in colorectal cancer: relationship with microsatellite instability, CpG island methylator phenotype, and p53.
Author: Kawasaki, Takako|Nosho, Katsuhiko|Ohnishi, Mutsuko|Suemoto, Yuko|Kirkner, Gregory J|Fuchs, Charles S|Ogino, Shuji
PMID: 18084616
Journal: Mod Pathol. 2008 Feb;21(2):150-8. Epub 2007 Dec 14.
Title: WRN promoter methylation possibly connects mucinous differentiation, microsatellite instability and CpG island methylator phenotype in colorectal cancer.
Author: Kawasaki, Takako|Ohnishi, Mutsuko|Suemoto, Yuko|Kirkner, Gregory J|Liu, Zhiqian|Yamamoto, Hiroyuki|Loda, Massimo|Fuchs, Charles S|Ogino, Shuji
PMID: 18084250
Journal: Mod Pathol. 2008 Mar;21(3):245-55.
Title: CpG island methylator phenotype-low (CIMP-low) colorectal cancer shows not only few methylated CIMP-high-specific CpG islands, but also low-level methylation at individual loci.
Author: Kawasaki, Takako|Ohnishi, Mutsuko|Nosho, Katsuhiko|Suemoto, Yuko|Kirkner, Gregory J|Meyerhardt, Jeffrey A|Fuchs, Charles S|Ogino, Shuji
PMID: 18204436
Journal: Int J Cancer. 2008 Jun 15;122(12):2767-73.
Title: LINE-1 hypomethylation is inversely associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer.
Author: Ogino, Shuji|Kawasaki, Takako|Nosho, Katsuhiko|Ohnishi, Mutsuko|Suemoto, Yuko|Kirkner, Gregory J|Fuchs, Charles S
PMID: 18366060
Journal: Neoplasia. 2008 Jun;10(6):534-41.
Title: PIK3CA mutation in colorectal cancer: relationship with genetic and epigenetic alterations.
Author: Nosho, Katsuhiko|Kawasaki, Takako|Ohnishi, Mutsuko|Suemoto, Yuko|Kirkner, Gregory J|Zepf, Dimity|Yan, Liying|Longtine, Janina A|Fuchs, Charles S|Ogino, Shuji
PMID: 18516290
Journal: PLoS Genet. 2008 Jun 13;4(6):e1000092.
Title: Novel roles for MLH3 deficiency and TLE6-like amplification in DNA mismatch repair-deficient gastrointestinal tumorigenesis and progression.
Author: Chen, Peng-Chieh|Kuraguchi, Mari|Velasquez, John|Wang, Yuxun|Yang, Kan|Edwards, Robert|Gillen, Dan|Edelmann, Winfried|Kucherlapati, Raju|Lipkin, Steven M
PMID: 18551179
Journal: Cancer Epidemiol Biomarkers Prev. 2008 Jul;17(7):1774-80.
Title: Ethnicity and risk for colorectal cancers showing somatic BRAF V600E mutation or CpG island methylator phenotype.
Author: English, Dallas R|Young, Joanne P|Simpson, Julie A|Jenkins, Mark A|Southey, Melissa C|Walsh, Michael D|Buchanan, Daniel D|Barker, Melissa A|Haydon, Andrew M|Royce, Simon G|Roberts, Aedan|Parry, Susan|Hopper, John L|Jass, Jeremy J|Giles, Graham G
PMID: 18628431
Journal: Cancer Cell. 2008 Sep 9;14(3):226-37.
Title: RUNX3 attenuates beta-catenin/T cell factors in intestinal tumorigenesis.
Author: Ito, Kosei|Lim, Anthony Chee-Beng|Salto-Tellez, Manuel|Motoda, Lena|Osato, Motomi|Chuang, Linda Shyue Huey|Lee, Cecilia Wei Lin|Voon, Dominic Chih-Cheng|Koo, Jason Kin Wai|Wang, Huajing|Fukamachi, Hiroshi|Ito, Yoshiaki
PMID: 18772112
Journal: Arch Pathol Lab Med. 2008 Oct;132(10):1657-65.
Title: CpG island methylator phenotype in colorectal cancers: comparison of the new and classic CpG island methylator phenotype marker panels.
Author: Lee, Sun|Cho, Nam-Yun|Yoo, Eun Joo|Kim, Jung Ho|Kang, Gyeong Hoon
PMID: 18834226
Journal: Int J Oncol. 2008 Nov;33(5):979-84.
Title: Inhibition of the growth and metastasis of human colon cancer by restoration of RUNX3 expression in cancer cells.
Author: Peng, Zhihai|Tang, Huamei|Wang, Xiaoliang|Zhou, Chongzhi|Fan, Junwei|Wang, Liwei|Jia, Zhiliang|Li, Qiang|Le, Xiangdong|Wei, Daoyan|Xie, Keping
PMID: 18949360
Journal: Histopathology. 2008 Nov;53(5):588-98.
Title: Cyclin D1 is frequently overexpressed in microsatellite unstable colorectal cancer, independent of CpG island methylator phenotype.
Author: Nosho, K|Kawasaki, T|Chan, A T|Ohnishi, M|Suemoto, Y|Kirkner, G J|Fuchs, C S|Ogino, S
PMID: 18983468
Journal: PLoS One. 2008;3(11):e3698.
Title: Comprehensive biostatistical analysis of CpG island methylator phenotype in colorectal cancer using a large population-based sample.
Author: Nosho, Katsuhiko|Irahara, Natsumi|Shima, Kaori|Kure, Shoko|Kirkner, Gregory J|Schernhammer, Eva S|Hazra, Aditi|Hunter, David J|Quackenbush, John|Spiegelman, Donna|Giovannucci, Edward L|Fuchs, Charles S|Ogino, Shuji
PMID: 19002263
Journal: Mol Cancer. 2008 Dec 31;7:94.
Title: Gene methylation profiles of normal mucosa, and benign and malignant colorectal tumors identify early onset markers.
Author: Ahlquist, Terje|Lind, Guro E|Costa, Vera L|Meling, Gunn I|Vatn, Morten|Hoff, Geir S|Rognum, Torleiv O|Skotheim, Rolf I|Thiis-Evensen, Espen|Lothe, Ragnhild A
PMID: 19117505
Journal: Gut. 2009 Jan;58(1):90-6.
Title: CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer.
Author: Ogino, Shuji|Nosho, Katsuhiko|Kirkner, Gregory J|Kawasaki, Takako|Meyerhardt, Jeffrey A|Loda, Massimo|Giovannucci, Edward L|Fuchs, Charles S
PMID: 18832519
Journal: Biomed Pharmacother. 2009 Aug;63(7):492-500.
Title: 5-Aza-2'-deoxycytidine reactivates expression of RUNX3 by deletion of DNA methyltransferases leading to caspase independent apoptosis in colorectal cancer Lovo cells.
Author: Deng, Tao|Zhang, Yan
PMID: 18848767
Journal: Neoplasia. 2009 Jan;11(1):87-95.
Title: JC virus T-antigen in colorectal cancer is associated with p53 expression and chromosomal instability, independent of CpG island methylator phenotype.
Author: Nosho, Katsuhiko|Shima, Kaori|Kure, Shoko|Irahara, Natsumi|Baba, Yoshifumi|Chen, Li|Kirkner, Gregory J|Fuchs, Charles S|Ogino, Shuji
PMID: 19107235
Journal: Am J Gastroenterol. 2009 Feb;104(2):426-36.
Title: RUNX3 inactivation in colorectal polyps arising through different pathways of colonic carcinogenesis.
Author: Subramaniam, Manish M|Chan, Jason Y|Soong, Richie|Ito, Kosei|Yeoh, Khay G|Wong, Reuben|Guenther, Thomas|Will, Olivia|Chen, Chee L|Kumarasinghe, Marian P|Ito, Yoshiaki|Salto-Tellez, Manuel
PMID: 19174785
Journal: Br J Cancer. 2009 Mar 10;100(5):676-9.
Title: The expression of RUNX3 in colorectal cancer is associated with disease stage and patient outcome.
Author: Soong, R|Shah, N|Peh, B K|Chong, P Y|Ng, S S|Zeps, N|Joseph, D|Salto-Tellez, M|Iacopetta, B|Ito, Y
PMID: 19223906
Journal: Mod Pathol. 2009 Jul;22(7):922-32.
Title: SIRT1 histone deacetylase expression is associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer.
Author: Nosho, Katsuhiko|Shima, Kaori|Irahara, Natsumi|Kure, Shoko|Firestein, Ron|Baba, Yoshifumi|Toyoda, Saori|Chen, Li|Hazra, Aditi|Giovannucci, Edward L|Fuchs, Charles S|Ogino, Shuji
PMID: 19430421
Journal: Clin Cancer Res. 2009 Jun 1;15(11):3663-71.
Title: DNMT3B expression might contribute to CpG island methylator phenotype in colorectal cancer.
Author: Nosho, Katsuhiko|Shima, Kaori|Irahara, Natsumi|Kure, Shoko|Baba, Yoshifumi|Kirkner, Gregory J|Chen, Li|Gokhale, Sumita|Hazra, Aditi|Spiegelman, Donna|Giovannucci, Edward L|Jaenisch, Rudolf|Fuchs, Charles S|Ogino, Shuji
PMID: 19470733
Journal: Pathobiology. 2009;76(4):163-9.
Title: RUNX3 inhibits cell proliferation and induces apoptosis by TGF-beta-dependent and -independent mechanisms in human colon carcinoma cells.
Author: Tong, Dan-Dan|Jiang, Ying|Li, Ming|Kong, Dan|Meng, Xiang-Nin|Zhao, Yu-Zhen|Jin, Yan|Bai, Jing|Fu, Song-Bin|Geng, Jing-Shu
PMID: 19571605
Journal: Biochim Biophys Acta. 2009 Dec;1796(2):315-31.
Title: Molecular pathology of RUNX3 in human carcinogenesis.
Author: Subramaniam, Manish Mani|Chan, Jason Yongsheng|Yeoh, Khay Guan|Quek, Timothy|Ito, Kosei|Salto-Tellez, Manuel
PMID: 19682550
Journal: Gastroenterology. 2009 Nov;137(5):1609-20.e1-3.
Title: A prospective cohort study shows unique epigenetic, genetic, and prognostic features of synchronous colorectal cancers.
Author: Nosho, Katsuhiko|Kure, Shoko|Irahara, Natsumi|Shima, Kaori|Baba, Yoshifumi|Spiegelman, Donna|Meyerhardt, Jeffrey A|Giovannucci, Edward L|Fuchs, Charles S|Ogino, Shuji
PMID: 19686742
Journal: Cancer Epidemiol Biomarkers Prev. 2009 Oct;18(10):2765-72.
Title: Vitamin D receptor expression is associated with PIK3CA and KRAS mutations in colorectal cancer.
Author: Kure, Shoko|Nosho, Katsuhiko|Baba, Yoshifumi|Irahara, Natsumi|Shima, Kaori|Ng, Kimmie|Meyerhardt, Jeffrey A|Giovannucci, Edward L|Fuchs, Charles S|Ogino, Shuji
PMID: 19789368
Journal: Clin Cancer Res. 2009 Oct 15;15(20):6412-20.
Title: Lymphocytic reaction to colorectal cancer is associated with longer survival, independent of lymph node count, microsatellite instability, and CpG island methylator phenotype.
Author: Ogino, Shuji|Nosho, Katsuhiko|Irahara, Natsumi|Meyerhardt, Jeffrey A|Baba, Yoshifumi|Shima, Kaori|Glickman, Jonathan N|Ferrone, Cristina R|Mino-Kenudson, Mari|Tanaka, Noriko|Dranoff, Glenn|Giovannucci, Edward L|Fuchs, Charles S
PMID: 19825961
Journal: Oncol Rep. 2010 Jan;23(1):191-7.
Title: CpG island methylation of BNIP3 predicts resistance against S-1/CPT-11 combined therapy in colorectal cancer patients.
Author: Hiraki, Masatsugu|Kitajima, Yoshihiko|Nakafusa, Yuji|Nakamura, Jun|Hashiguchi, Kazuyoshi|Sumi, Kenji|Noshiro, Hirokazu|Miyazaki, Kohji
PMID: 19956881
Journal: Gastroenterology. 2010 May;138(5):1854-62.
Title: Aberrant DNA methylation in hereditary nonpolyposis colorectal cancer without mismatch repair deficiency.
Author: Goel, Ajay|Xicola, Rosa M|Nguyen, Thuy-Phuong|Doyle, Brian J|Sohn, Vanessa R|Bandipalliam, Prathap|Rozek, Laura S|Reyes, Josep|Cordero, Carmen|Balaguer, Francesc|Castells, Antoni|Jover, Rodrigo|Andreu, Montserrat|Syngal, Sapna|Boland, C Richard|Llor, Xavi
PMID: 20102720
Journal: Am J Gastroenterol. 2010 Jul;105(7):1610-9.
Title: Methylation status of genes in non-neoplastic mucosa from patients with ulcerative colitis-associated colorectal cancer.
Author: Garrity-Park, Megan M|Loftus, Edward V Jr|Sandborn, William J|Bryant, Sandra C|Smyrk, Thomas C
PMID: 20160714
Journal: Cancer Epidemiol Biomarkers Prev. 2010 Mar;19(3):822-31.
Title: PTGER2 overexpression in colorectal cancer is associated with microsatellite instability, independent of CpG island methylator phenotype.
Author: Baba, Yoshifumi|Nosho, Katsuhiko|Shima, Kaori|Goessling, Wolfram|Chan, Andrew T|Ng, Kimmie|Chan, Jennifer A|Giovannucci, Edward L|Fuchs, Charles S|Ogino, Shuji
PMID: 20200425
Journal: Cancer Epidemiol. 2010 Jun;34(3):338-44.
Title: Polymorphisms in methyl-group metabolism genes and risk of sporadic colorectal cancer with relation to the CpG island methylator phenotype.
Author: Karpinski, Pawel|Myszka, Aleksander|Ramsey, David|Misiak, Blazej|Gil, Justyna|Laczmanska, Izabela|Grzebieniak, Zygmunt|Sebzda, Tadeusz|Smigiel, Robert|Stembalska, Agnieszka|Sasiadek, Maria M
PMID: 20381446
Journal: Cancer Res. 2010 May 15;70(10):4243-52.
Title: Role of RUNX3 in bone morphogenetic protein signaling in colorectal cancer.
Author: Lee, Cecilia Wei Lin|Ito, Kosei|Ito, Yoshiaki
PMID: 20442291
Journal: Carcinogenesis. 2010 Sep;31(9):1567-75.
Title: The role of EZH2 and DNA methylation in the silencing of the tumour suppressor RUNX3 in colorectal cancer.
Author: Kodach, Liudmila L|Jacobs, Rutger J|Heijmans, Jarom|van Noesel, Carel J M|Langers, Alexandra M J|Verspaget, Hein W|Hommes, Daniel W|Offerhaus, G Johan A|van den Brink, Gijs R|Hardwick, James C H
PMID: 20631058
Journal: Anticancer Res. 2010 Jul;30(7):2673-82.
Title: RUNX3 promoter methylation in colorectal cancer: its relationship with microsatellite instability and its suitability as a novel serum tumor marker.
Author: Nishio, Minoru|Sakakura, Chouhei|Nagata, Tomoyuki|Komiyama, Sosuke|Miyashita, Atsushi|Hamada, Takuo|Kuryu, Yoshiaki|Ikoma, Hisashi|Kubota, Takeshi|Kimura, Akio|Nakanishi, Masayoshi|Ichikawa, Daisuke|Fujiwara, Hitoshi|Okamoto, Kazuma|Ochiai, Toshiya|Kokuba
PMID: 20682997
Journal: Am J Pathol. 2010 Dec;177(6):2731-40.
Title: Novel application of structural equation modeling to correlation structure analysis of CpG island methylation in colorectal cancer.
Author: Tanaka, Noriko|Huttenhower, Curtis|Nosho, Katsuhiko|Baba, Yoshifumi|Shima, Kaori|Quackenbush, John|Haigis, Kevin M|Giovannucci, Edward|Fuchs, Charles S|Ogino, Shuji
PMID: 21037082
Journal: Anticancer Res. 2010 Dec;30(12):4811-8.
Title: Aberrant methylation of heparan sulfate glucosamine 3-O-sulfotransferase 2 genes as a biomarker in colorectal cancer.
Author: Tokuyama, Yasuharu|Takahashi, Takao|Okumura, Naoki|Nonaka, Kenichi|Kawaguchi, Yoshihiro|Yamaguchi, Kazuya|Osada, Shinji|Gazdar, Adi|Yoshida, Kazuhiro
PMID: 21187457
Journal: Int J Cancer. 2011 Mar 1;128(5):1080-94.
Title: Prognostic significance of CDKN2A (p16) promoter methylation and loss of expression in 902 colorectal cancers: Cohort study and literature review.
Author: Shima, Kaori|Nosho, Katsuhiko|Baba, Yoshifumi|Cantor, Mami|Meyerhardt, Jeffrey A|Giovannucci, Edward L|Fuchs, Charles S|Ogino, Shuji
PMID: 20473920
Journal: Gut. 2011 Apr;60(4):499-508.
Title: Sequential DNA methylation changes are associated with DNMT3B overexpression in colorectal neoplastic progression.
Author: Ibrahim, Ashraf E K|Arends, Mark J|Silva, Ana-Luisa|Wyllie, Andrew H|Greger, Liliana|Ito, Yoko|Vowler, Sarah L|Huang, Tim H-M|Tavare, Simon|Murrell, Adele|Brenton, James D
PMID: 21068132
Journal: Carcinogenesis. 2011 Mar;32(3):318-26.
Title: Associations between genetic variation in RUNX1, RUNX2, RUNX3, MAPK1 and eIF4E and riskof colon and rectal cancer: additional support for a TGF-beta-signaling pathway.
Author: Slattery, Martha L|Lundgreen, Abbie|Herrick, Jennifer S|Caan, Bette J|Potter, John D|Wolff, Roger K
PMID: 21088106
Journal: Int J Oncol. 2011 Jan;38(1):201-7.
Title: RUNX3 copy number predicts the development of UC-associated colorectal cancer.
Author: Watanabe, Toshiaki|Kobunai, Takashi|Ikeuchi, Hiroki|Yamamoto, Yoko|Matsuda, Keiji|Ishihara, Soichiro|Nozawa, Keijiro|Iinuma, Hisae|Kanazawa, Takamitsu|Tanaka, Toshiaki|Yokoyama, Tadashi|Konishi, Tsuyoshi|Eshima, Kiyoshi|Ajioka, Yoichi|Hibi, Toshifumi|Wata
PMID: 21109941
Journal: Cancer Causes Control. 2011 Feb;22(2):301-9.
Title: MGMT promoter methylation, loss of expression and prognosis in 855 colorectal cancers.
Author: Shima, Kaori|Morikawa, Teppei|Baba, Yoshifumi|Nosho, Katsuhiko|Suzuki, Maiko|Yamauchi, Mai|Hayashi, Marika|Giovannucci, Edward|Fuchs, Charles S|Ogino, Shuji
PMID: 21140203
Journal: Gastroenterology. 2011 Apr;140(4):1174-81.
Title: 5-Fluorouracil adjuvant chemotherapy does not increase survival in patients with CpG island methylator phenotype colorectal cancer.
Author: Jover, Rodrigo|Nguyen, Thuy-Phuong|Perez-Carbonell, Lucia|Zapater, Pedro|Paya, Artemio|Alenda, Cristina|Rojas, Estefania|Cubiella, Joaquin|Balaguer, Francesc|Morillas, Juan D|Clofent, Juan|Bujanda, Luis|Rene, Josep M|Bessa, Xavier|Xicola, Rosa M|Nicolas-P
PMID: 21185836
Journal: Cancer. 2011 Sep 15;117(18):4175-83.
Title: Genetic variation in the transforming growth factor-beta signaling pathway and survival after diagnosis with colon and rectal cancer.
Author: Slattery, Martha L|Lundgreen, Abbie|Herrick, Jennifer S|Wolff, Roger K|Caan, Bette J
PMID: 21365634
Journal: J Immunol. 2011 Jun 1;186(11):6515-20.
Title: Runx3 is required for full activation of regulatory T cells to prevent colitis-associated tumor formation.
Author: Sugai, Manabu|Aoki, Koji|Osato, Motomi|Nambu, Yukiko|Ito, Kosei|Taketo, Makoto M|Shimizu, Akira
PMID: 21515792
Journal: Tumour Biol. 2011 Aug;32(4):653-9.
Title: Detection of viral DNA sequences in sporadic colorectal cancers in relation to CpG island methylation and methylator phenotype.
Author: Karpinski, Pawel|Myszka, Aleksander|Ramsey, David|Kielan, Wojciech|Sasiadek, Maria Malgorzata
PMID: 21625944
Journal: PLoS One. 2011;6(6):e21102.
Title: B vitamins, methionine and alcohol intake and risk of colon cancer in relation to BRAF mutation and CpG island methylator phenotype (CIMP).
Author: Schernhammer, Eva S|Giovannucci, Edward|Baba, Yoshifumi|Fuchs, Charles S|Ogino, Shuji
PMID: 21738611
Journal: Clin Colorectal Cancer. 2011 Jun;10(2):134-41.
Title: Predicting ulcerative colitis-associated colorectal cancer using reverse-transcription polymerase chain reaction analysis.
Author: Watanabe, Toshiaki|Kobunai, Takashi|Yamamoto, Yoko|Ikeuchi, Hiroki|Matsuda, Keiji|Ishihara, Soichiro|Nozawa, Keijiro|Iinuma, Hisae|Kanazawa, Takamitsu|Tanaka, Toshiaki|Yokoyama, Tadashi|Konishi, Tsuyoshi|Eshima, Kiyoshi|Ajioka, Yohichi|Hibi, Toshifumi|Wat
PMID: 21859567
Journal: Hepatogastroenterology. 2011 Nov-Dec;58(112):2007-11.
Title: Analysis of the RUNX3 gene methylation in serum DNA from esophagus squamous cell carcinoma, gastric and colorectal adenocarcinoma patients.
Author: Zheng, Yun|Zhang, Youwei|Huang, Xiang|Chen, Longbang
PMID: 22234069
Journal: Inflamm Bowel Dis. 2012 Feb;18(2):275-83.
Title: Myeloperoxidase immunohistochemistry as a measure of disease activity in ulcerative colitis: association with ulcerative colitis-colorectal cancer, tumor necrosis factor polymorphism and RUNX3 methylation.
Author: Garrity-Park, Megan|Loftus, Edward V Jr|Sandborn, William J|Smyrk, Thomas C
PMID: 21425209
Journal: J Cell Physiol. 2012 Feb;227(2):839-49.
Title: Identification of RUNX3 as a component of the MST/Hpo signaling pathway.
Author: Min, Boram|Kim, Min-Kyu|Zhang, Joo-Won|Kim, Jiyeon|Chung, Kwang-Chul|Oh, Byung-Chul|Stein, Gary S|Lee, Yong-Hee|van Wijnen, Andre J|Bae, Suk-Chul
PMID: 21678419
Journal: Int J Surg Pathol. 2012 Apr;20(2):185-90.
Title: Rhabdoid carcinoma of the colon: a distinct entity with a very aggressive behavior: a case report associated with a polyposis coli and review of the literature.
Author: Remo, Andrea|Zanella, Caterina|Molinari, Enrico|Talamini, Alberto|Tollini, Filippo|Piacentini, Paolo|Battaglia, Paolo|Baritono, Elisabetta|Bonetti, Andrea|Lanza, Franco|Fasolin, Antonio|Manfrin, Erminia|Vendraminelli, Roberto
PMID: 21791485
Journal: Pathol Oncol Res. 2012 Apr;18(2):263-70.
Title: CDH13 and FLBN3 gene methylation are associated with poor prognosis in colorectal cancer.
Author: Wang, Zhu|Yuan, Xin|Jiao, Nanlin|Zhu, Hui|Zhang, Youwei|Tong, Jiandong
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Journal: Surgery. 2012 Apr;151(4):564-70.
Title: CpG island methylator phenotype infers a poor disease-free survival in locally advanced rectal cancer.
Author: Jo, Peter|Jung, Klaus|Grade, Marian|Conradi, Lena-Christin|Wolff, Hendrik A|Kitz, Julia|Becker, Heinz|Ruschoff, Josef|Hartmann, Arndt|Beissbarth, Tim|Muller-Dornieden, Annegret|Ghadimi, Michael|Schneider-Stock, Regine|Gaedcke, Jochen
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Journal: Tumour Biol. 2012 Apr;33(2):403-12.
Title: Epigenetic changes induced by oxidative stress in colorectal cancer cells: methylation of tumor suppressor RUNX3.
Author: Kang, Kyoung Ah|Zhang, Rui|Kim, Gi Young|Bae, Suk Chul|Hyun, Jin Won
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Journal: Int J Cancer. 2013 May 1;132(9):2209-16.
Title: Methylation and microsatellite status and recurrence following adjuvant FOLFOX in colorectal cancer.
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Journal: Carcinogenesis. 2013 Feb;34(2):292-8.
Title: Phenotypic and tumor molecular characterization of colorectal cancer in relation to a susceptibility SMAD7 variant associated with survival.
Author: Garcia-Albeniz, Xabier|Nan, Hongmei|Valeri, Linda|Morikawa, Teppei|Kuchiba, Aya|Phipps, Amanda I|Hutter, Carolyn M|Peters, Ulrike|Newcomb, Polly A|Fuchs, Charles S|Giovannucci, Edward L|Ogino, Shuji|Chan, Andrew T
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Journal: Mol Med Rep. 2013 May;7(5):1425-30.
Title: Effects of paeonol on intracellular calcium concentration and expression of RUNX3 in LoVo human colon cancer cells.
Author: Li, Ming|Tan, Shi-Yun|Zhang, Jun|You, Hong-Xia
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Journal: PLoS One. 2013;8(3):e58731.
Title: Somatic mutations, allele loss, and DNA methylation of the Cub and Sushi Multiple Domains 1 (CSMD1) gene reveals association with early age of diagnosis in colorectal cancer patients.
Author: Shull, Austin Y|Clendenning, Megan L|Ghoshal-Gupta, Sampa|Farrell, Christopher L|Vangapandu, Hima V|Dudas, Larry|Wilkerson, Brent J|Buckhaults, Phillip J
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Journal: Int J Oncol. 2013 Jul;43(1):228-36.
Title: The role of a ginseng saponin metabolite as a DNA methyltransferase inhibitor in colorectal cancer cells.
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Journal: Int J Oncol. 2013 Nov;43(5):1511-6.
Title: Oxidative stress induces proliferation of colorectal cancer cells by inhibiting RUNX3 and activating the Akt signaling pathway.
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Journal: Int J Oncol. 2013 Dec;43(6):1907-14.
Title: Compound K, a metabolite of ginseng saponin, inhibits colorectal cancer cell growth and induces apoptosis through inhibition of histone deacetylase activity.
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Title: DNA methylation as an epigenetic biomarker in colorectal cancer.
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Journal: Anticancer Res. 2014 Jan;34(1):133-40.
Title: Demethylation of RUNX3 by vincristine in colorectal adenocarcinoma cells.
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Journal: PLoS One. 2014 Jan 21;9(1):e86657.
Title: Comparison of CpG island methylator phenotype (CIMP) frequency in colon cancer using different probe- and gene-specific scoring alternatives on recommended multi-gene panels.
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Journal: Gastroenterology. 2014 Sep;147(3):637-45.
Title: CpG island methylator phenotype is associated with response to adjuvant irinotecan-based therapy for stage III colon cancer.
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Journal: Onco Targets Ther. 2014 Jul 10;7:1237-45.
Title: Clinical significance and association of RUNX3 hypermethylation frequency with colorectal cancer: a meta-analysis.
Author: Mu, Wei-Ping|Wang, Jian|Niu, Qiong|Shi, Ning|Lian, Hai-Feng
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Title: [Expression of Runx3 and C-myc in human colorectal cancer].
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Journal: Biomed Res Int. 2014;2014:236361.
Title: CpG island methylator phenotype and prognosis of colorectal cancer in Northeast China.
Author: Li, Xia|Hu, Fulan|Wang, Yibaina|Yao, Xiaoping|Zhang, Zuoming|Wang, Fan|Sun, Guizhi|Cui, Bin-Bin|Dong, Xinshu|Zhao, Yashuang
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Journal: PLoS One. 2014 Dec 26;9(12):e116169.
Title: The influence of the CHIEF pathway on colorectal cancer-specific mortality.
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Journal: Gut Liver. 2015 Mar;9(2):202-7.
Title: The role of the CpG island methylator phenotype on survival outcome in colon cancer.
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Journal: Digestion. 2015;91(1):57-63.
Title: Clinicopathological and molecular characteristics of serrated lesions in Japanese elderly patients.
Author: Nosho, Katsuhiko|Igarashi, Hisayoshi|Ito, Miki|Mitsuhashi, Kei|Kurihara, Hiroyoshi|Kanno, Shinichi|Yoshii, Shinji|Mikami, Masashi|Takahashi, Hiroaki|Kusumi, Takaya|Hosokawa, Masao|Sukawa, Yasutaka|Adachi, Yasushi|Hasegawa, Tadashi|Okita, Kenji|Hirata, Koi
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Title: Differential expressions of cancer-associated genes and their regulatory miRNAs in colorectal carcinoma.
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Journal: Int J Clin Exp Pathol. 2015 Feb 1;8(2):1920-8. eCollection 2015.
Title: Nuclear maspin expression correlates with the CpG island methylator phenotype and tumor aggressiveness in colorectal cancer.
Author: Kim, Jung Ho|Cho, Nam-Yun|Bae, Jeong Mo|Kim, Kyung-Ju|Rhee, Ye-Young|Lee, Hye Seung|Kang, Gyeong Hoon
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Journal: Int J Mol Med. 2015 Aug;36(2):473-84.
Title: Integrative genomic analyses of the RNA-binding protein, RNPC1, and its potential role in cancer prediction.
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Journal: Biomed Rep. 2015 Sep;3(5):687-690.
Title: Investigation of methylation and protein expression of the Runx3 gene in colon carcinogenesis.
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Title: RUNX3 gene polymorphisms and haplotypes in Mexican patients with colorectal cancer.
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Title: Evaluation of CpG Island Methylator Phenotype as a Biomarker in Colorectal Cancer Treated With Adjuvant Oxaliplatin.
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Title: Aberrant gene methylation in non-neoplastic mucosa as a predictive marker of ulcerative colitis-associated CRC.
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Title: Distinct features between MLH1-methylated and unmethylated colorectal carcinomas with the CpG island methylator phenotype: implications in the serrated neoplasia pathway.
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Journal: Inflamm Bowel Dis. 2016 Jul;22(7):1568-74.
Title: A Biomarker Panel to Detect Synchronous Neoplasm in Non-neoplastic Surveillance Biopsies from Patients with Ulcerative Colitis.
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Journal: Oncol Rep. 2016 Nov;36(5):2601-2608.
Title: RUNX3 inhibits the metastasis and angiogenesis of colorectal cancer.
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Journal: J Cell Physiol. 2017 Jul;232(7):1914-1921.
Title: Cytoplasmic Localization of RUNX3 via Histone Deacetylase-Mediated SRC Expression in Oxidative-Stressed Colon Cancer Cells.
Author: Kang, Kyoung Ah|Piao, Mei Jing|Ryu, Yea Seong|Maeng, Young Hee|Hyun, Jin Won
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Journal: Oncotarget. 2017 Mar 7;8(10):16765-16783.
Title: Genetic variants in the TGFbeta-signaling pathway influence expression of miRNAs in colon and rectal normal mucosa and tumor tissue.
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Journal: Asian Pac J Trop Med. 2017 Jan;10(1):98-101.
Title: Correlation of RUNX3 expression with microvessel density in colorectal adenocarcinoma tissues and clinical significance.
Author: Xue, Jun|Wu, Xue-Liang|Huang, Xian-Tao|Qu, Ming|Guo, Fei|Sun, Guang-Yuan|Zhang, Peng-Cheng|Han, Lei|Pan, Li-Ming
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Title: The CpG island methylator phenotype is concordant between primary colorectal carcinoma and matched distant metastases.
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Journal: Int J Oncol. 2017 Jun;50(6):2059-2068.
Title: Effects of RUNX3 mediated Notch signaling pathway on biological characteristics of colorectal cancer cells.
Author: Li, Hang|Li, Dan|Meng, Ning
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Journal: Int J Cancer. 2017 Sep 1;141(5):967-976.
Title: CpG island methylator phenotype identifies high risk patients among microsatellite stable BRAF mutated colorectal cancers.
Author: Vedeld, Hege Marie|Merok, Marianne|Jeanmougin, Marine|Danielsen, Stine A|Honne, Hilde|Presthus, Gro Kummeneje|Svindland, Aud|Sjo, Ole H|Hektoen, Merete|Eknaes, Mette|Nesbakken, Arild|Lothe, Ragnhild A|Lind, Guro E
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Journal: Epigenomics. 2017 Jul;9(7):1029-1042.
Title: DNA methylation patterns in ulcerative colitis-associated cancer: a systematic review.
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Journal: J Mass Spectrom. 2017 Dec;52(12):860-866.
Title: Screening of exon methylation biomarkers for colorectal cancer via LC-MS/MS strategy.
Author: Huang, Qionglin|Yang, Qingjin|Mo, Mingming|Ye, Xiaoxia|Zhang, Junjie|Zhang, Lijian|Chen, Bin|Li, Jian|Cai, Chun
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Journal: Oncol Lett. 2017 Nov;14(5):6203-6209.
Title: JAB1-STAT3 activation loop is associated with recurrence following 5-fluorouracil-based adjuvant chemotherapy in human colorectal cancer.
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Title: Genomic heterogeneity in primary colorectal carcinomas and their metastases: born bad or brought up a villain?
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Journal: Ann Surg Treat Res. 2018 Jan;94(1):19-25.
Title: Epigenetic inactivation of RUNX3 in colorectal cancer.
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Title: CORRIGENDUM: Correction of funding statement in ACKNOWLEDGEMENTS section: Epigenetic inactivation of RUNX3 in colorectal cancer.
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Title: Oncogenic role of microRNA-532-5p in human colorectal cancer via targeting of the 5'UTR of RUNX3.
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Title: Prognostic Value of Methylator Phenotype in Stage III Colon Cancer Treated with Oxaliplatin-based Adjuvant Chemotherapy.
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Journal: Sci Rep. 2018 Jun 21;8(1):9470.
Title: Lifestyle Factors, Colorectal Tumor Methylation, and Survival Among African Americans and European Americans.
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Journal: J Cell Biochem. 2018 Oct 25.
Title: Overexpression of miR-301a-3p promotes colorectal cancer cell proliferation and metastasis by targeting deleted in liver cancer-1 and runt-related transcription factor 3.
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