Primary Site >> Colorectal Cancer
Gene >> RUNX3
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Ref: Methylation of RUNX3 in various types of human cancers and premalignant stages of gastric carcinoma. PMID: 14968123 Ref: Promoter hypermethylation downregulates RUNX3 gene expression in colorectal cancer cell lines. PMID: 15273736 Ref: Epigenetic inactivation of RUNX3 in microsatellite unstable sporadic colon cancers. PMID: 15386381 |
Ref: RUNX3 promoter region is specifically methylated in poorly-differentiated colorectal cancer. PMID: 16080503 |
Ref: Lymph node metastasis is infrequent in patients with highly-methylated colorectal cancer. PMID: 16475679 Ref: Hedgehog signaling pathway and gastrointestinal stem cell signaling network (review). PMID: 17089004 |
Ref: The CpG island methylator phenotype and chromosomal instability are inversely correlated in sporadic colorectal cancer. PMID: 17087942 Ref: Cytoplasmic localization of p27 (cyclin-dependent kinase inhibitor 1B/KIP1) in colorectal cancer: inverse correlations with nuclear p27 loss, microsatellite instability, and CpG island methylator phenotype. PMID: 17239930 Ref: TGFBR2 mutation is correlated with CpG island methylator phenotype in microsatellite instability-high colorectal cancer. PMID: 17270239 Ref: Molecular correlates with MGMT promoter methylation and silencing support CpG island methylator phenotype-low (CIMP-low) in colorectal cancer. PMID: 17339237 Ref: Fatty acid synthase overexpression in colorectal cancer is associated with microsatellite instability, independent of CpG island methylator phenotype. PMID: 17350669 Ref: CpG island methylation, response to combination chemotherapy, and patient survival in advanced microsatellite stable colorectal carcinoma. PMID: 17372756 Ref: 18q loss of heterozygosity in microsatellite stable colorectal cancer is correlated with CpG island methylator phenotype-negative (CIMP-0) and inversely with CIMP-low and CIMP-high. PMID: 17474983 Ref: Evaluation of markers for CpG island methylator phenotype (CIMP) in colorectal cancer by a large population-based sample. PMID: 17591929 Ref: MGMT germline polymorphism is associated with somatic MGMT promoter methylation and gene silencing in colorectal cancer. PMID: 17621591 Ref: Correlation of beta-catenin localization with cyclooxygenase-2 expression and CpG island methylator phenotype (CIMP) in colorectal cancer. PMID: 17710160 Ref: Promoter methylation status of multiple genes in uveal melanoma. PMID: 17898258 Ref: IGFBP3 promoter methylation in colorectal cancer: relationship with microsatellite instability, CpG island methylator phenotype, and p53. PMID: 18084616 |
Ref: WRN promoter methylation possibly connects mucinous differentiation, microsatellite instability and CpG island methylator phenotype in colorectal cancer. PMID: 18084250 Ref: CpG island methylator phenotype-low (CIMP-low) colorectal cancer shows not only few methylated CIMP-high-specific CpG islands, but also low-level methylation at individual loci. PMID: 18204436 Ref: LINE-1 hypomethylation is inversely associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer. PMID: 18366060 Ref: PIK3CA mutation in colorectal cancer: relationship with genetic and epigenetic alterations. PMID: 18516290 Ref: Novel roles for MLH3 deficiency and TLE6-like amplification in DNA mismatch repair-deficient gastrointestinal tumorigenesis and progression. PMID: 18551179 Ref: Ethnicity and risk for colorectal cancers showing somatic BRAF V600E mutation or CpG island methylator phenotype. PMID: 18628431 Ref: RUNX3 attenuates beta-catenin/T cell factors in intestinal tumorigenesis. PMID: 18772112 Ref: CpG island methylator phenotype in colorectal cancers: comparison of the new and classic CpG island methylator phenotype marker panels. PMID: 18834226 Ref: Inhibition of the growth and metastasis of human colon cancer by restoration of RUNX3 expression in cancer cells. PMID: 18949360 Ref: Cyclin D1 is frequently overexpressed in microsatellite unstable colorectal cancer, independent of CpG island methylator phenotype. PMID: 18983468 Ref: Comprehensive biostatistical analysis of CpG island methylator phenotype in colorectal cancer using a large population-based sample. PMID: 19002263 Ref: Gene methylation profiles of normal mucosa, and benign and malignant colorectal tumors identify early onset markers. PMID: 19117505 |
Ref: CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer. PMID: 18832519 Ref: 5-Aza-2'-deoxycytidine reactivates expression of RUNX3 by deletion of DNA methyltransferases leading to caspase independent apoptosis in colorectal cancer Lovo cells. PMID: 18848767 Ref: JC virus T-antigen in colorectal cancer is associated with p53 expression and chromosomal instability, independent of CpG island methylator phenotype. PMID: 19107235 Ref: RUNX3 inactivation in colorectal polyps arising through different pathways of colonic carcinogenesis. PMID: 19174785 Ref: The expression of RUNX3 in colorectal cancer is associated with disease stage and patient outcome. PMID: 19223906 Ref: SIRT1 histone deacetylase expression is associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer. PMID: 19430421 Ref: DNMT3B expression might contribute to CpG island methylator phenotype in colorectal cancer. PMID: 19470733 Ref: RUNX3 inhibits cell proliferation and induces apoptosis by TGF-beta-dependent and -independent mechanisms in human colon carcinoma cells. PMID: 19571605 Ref: Molecular pathology of RUNX3 in human carcinogenesis. PMID: 19682550 Ref: A prospective cohort study shows unique epigenetic, genetic, and prognostic features of synchronous colorectal cancers. PMID: 19686742 Ref: Vitamin D receptor expression is associated with PIK3CA and KRAS mutations in colorectal cancer. PMID: 19789368 Ref: Lymphocytic reaction to colorectal cancer is associated with longer survival, independent of lymph node count, microsatellite instability, and CpG island methylator phenotype. PMID: 19825961 |
Ref: CpG island methylation of BNIP3 predicts resistance against S-1/CPT-11 combined therapy in colorectal cancer patients. PMID: 19956881 Ref: Aberrant DNA methylation in hereditary nonpolyposis colorectal cancer without mismatch repair deficiency. PMID: 20102720 Ref: Methylation status of genes in non-neoplastic mucosa from patients with ulcerative colitis-associated colorectal cancer. PMID: 20160714 Ref: PTGER2 overexpression in colorectal cancer is associated with microsatellite instability, independent of CpG island methylator phenotype. PMID: 20200425 Ref: Polymorphisms in methyl-group metabolism genes and risk of sporadic colorectal cancer with relation to the CpG island methylator phenotype. PMID: 20381446 Ref: Role of RUNX3 in bone morphogenetic protein signaling in colorectal cancer. PMID: 20442291 Ref: The role of EZH2 and DNA methylation in the silencing of the tumour suppressor RUNX3 in colorectal cancer. PMID: 20631058 Ref: RUNX3 promoter methylation in colorectal cancer: its relationship with microsatellite instability and its suitability as a novel serum tumor marker. PMID: 20682997 Ref: Novel application of structural equation modeling to correlation structure analysis of CpG island methylation in colorectal cancer. PMID: 21037082 Ref: Aberrant methylation of heparan sulfate glucosamine 3-O-sulfotransferase 2 genes as a biomarker in colorectal cancer. PMID: 21187457 |
Ref: Prognostic significance of CDKN2A (p16) promoter methylation and loss of expression in 902 colorectal cancers: Cohort study and literature review. PMID: 20473920 Ref: Sequential DNA methylation changes are associated with DNMT3B overexpression in colorectal neoplastic progression. PMID: 21068132 Ref: Associations between genetic variation in RUNX1, RUNX2, RUNX3, MAPK1 and eIF4E and riskof colon and rectal cancer: additional support for a TGF-beta-signaling pathway. PMID: 21088106 Ref: RUNX3 copy number predicts the development of UC-associated colorectal cancer. PMID: 21109941 Ref: MGMT promoter methylation, loss of expression and prognosis in 855 colorectal cancers. PMID: 21140203 Ref: 5-Fluorouracil adjuvant chemotherapy does not increase survival in patients with CpG island methylator phenotype colorectal cancer. PMID: 21185836 Ref: Genetic variation in the transforming growth factor-beta signaling pathway and survival after diagnosis with colon and rectal cancer. PMID: 21365634 Ref: Runx3 is required for full activation of regulatory T cells to prevent colitis-associated tumor formation. PMID: 21515792 Ref: Detection of viral DNA sequences in sporadic colorectal cancers in relation to CpG island methylation and methylator phenotype. PMID: 21625944 Ref: B vitamins, methionine and alcohol intake and risk of colon cancer in relation to BRAF mutation and CpG island methylator phenotype (CIMP). PMID: 21738611 Ref: Predicting ulcerative colitis-associated colorectal cancer using reverse-transcription polymerase chain reaction analysis. PMID: 21859567 Ref: Analysis of the RUNX3 gene methylation in serum DNA from esophagus squamous cell carcinoma, gastric and colorectal adenocarcinoma patients. PMID: 22234069 |
Ref: Myeloperoxidase immunohistochemistry as a measure of disease activity in ulcerative colitis: association with ulcerative colitis-colorectal cancer, tumor necrosis factor polymorphism and RUNX3 methylation. PMID: 21425209 Ref: Identification of RUNX3 as a component of the MST/Hpo signaling pathway. PMID: 21678419 Ref: Rhabdoid carcinoma of the colon: a distinct entity with a very aggressive behavior: a case report associated with a polyposis coli and review of the literature. PMID: 21791485 Ref: CDH13 and FLBN3 gene methylation are associated with poor prognosis in colorectal cancer. PMID: 21796503 Ref: CpG island methylator phenotype infers a poor disease-free survival in locally advanced rectal cancer. PMID: 22001634 Ref: Epigenetic changes induced by oxidative stress in colorectal cancer cells: methylation of tumor suppressor RUNX3. PMID: 22274925 |
Ref: Methylation and microsatellite status and recurrence following adjuvant FOLFOX in colorectal cancer. PMID: 23034738 Ref: Phenotypic and tumor molecular characterization of colorectal cancer in relation to a susceptibility SMAD7 variant associated with survival. PMID: 23104301 Ref: Effects of paeonol on intracellular calcium concentration and expression of RUNX3 in LoVo human colon cancer cells. PMID: 23504038 Ref: Somatic mutations, allele loss, and DNA methylation of the Cub and Sushi Multiple Domains 1 (CSMD1) gene reveals association with early age of diagnosis in colorectal cancer patients. PMID: 23505554 Ref: The role of a ginseng saponin metabolite as a DNA methyltransferase inhibitor in colorectal cancer cells. PMID: 23652987 Ref: Oxidative stress induces proliferation of colorectal cancer cells by inhibiting RUNX3 and activating the Akt signaling pathway. PMID: 24042352 Ref: Compound K, a metabolite of ginseng saponin, inhibits colorectal cancer cell growth and induces apoptosis through inhibition of histone deacetylase activity. PMID: 24100442 Ref: DNA methylation as an epigenetic biomarker in colorectal cancer. PMID: 24260063 |
Ref: Demethylation of RUNX3 by vincristine in colorectal adenocarcinoma cells. PMID: 24403453 Ref: Comparison of CpG island methylator phenotype (CIMP) frequency in colon cancer using different probe- and gene-specific scoring alternatives on recommended multi-gene panels. PMID: 24466191 Ref: CpG island methylator phenotype is associated with response to adjuvant irinotecan-based therapy for stage III colon cancer. PMID: 24859205 Ref: Clinical significance and association of RUNX3 hypermethylation frequency with colorectal cancer: a meta-analysis. PMID: 25053885 Ref: [Expression of Runx3 and C-myc in human colorectal cancer]. PMID: 25057081 Ref: CpG island methylator phenotype and prognosis of colorectal cancer in Northeast China. PMID: 25243122 Ref: The influence of the CHIEF pathway on colorectal cancer-specific mortality. PMID: 25541970 |
Ref: The role of the CpG island methylator phenotype on survival outcome in colon cancer. PMID: 25167802 Ref: Clinicopathological and molecular characteristics of serrated lesions in Japanese elderly patients. PMID: 25632919 Ref: Differential expressions of cancer-associated genes and their regulatory miRNAs in colorectal carcinoma. PMID: 25925209 Ref: Nuclear maspin expression correlates with the CpG island methylator phenotype and tumor aggressiveness in colorectal cancer. PMID: 25973084 Ref: Integrative genomic analyses of the RNA-binding protein, RNPC1, and its potential role in cancer prediction. PMID: 26046131 Ref: Investigation of methylation and protein expression of the Runx3 gene in colon carcinogenesis. PMID: 26405546 Ref: RUNX3 gene polymorphisms and haplotypes in Mexican patients with colorectal cancer. PMID: 26634516 |
Ref: Evaluation of CpG Island Methylator Phenotype as a Biomarker in Colorectal Cancer Treated With Adjuvant Oxaliplatin. PMID: 26702772 Ref: Aberrant gene methylation in non-neoplastic mucosa as a predictive marker of ulcerative colitis-associated CRC. PMID: 26862732 Ref: Distinct features between MLH1-methylated and unmethylated colorectal carcinomas with the CpG island methylator phenotype: implications in the serrated neoplasia pathway. PMID: 26883113 Ref: A Biomarker Panel to Detect Synchronous Neoplasm in Non-neoplastic Surveillance Biopsies from Patients with Ulcerative Colitis. PMID: 27135485 Ref: RUNX3 inhibits the metastasis and angiogenesis of colorectal cancer. PMID: 27633042 |
Ref: Cytoplasmic Localization of RUNX3 via Histone Deacetylase-Mediated SRC Expression in Oxidative-Stressed Colon Cancer Cells. PMID: 27990641 Ref: Genetic variants in the TGFbeta-signaling pathway influence expression of miRNAs in colon and rectal normal mucosa and tumor tissue. PMID: 28061442 Ref: Correlation of RUNX3 expression with microvessel density in colorectal adenocarcinoma tissues and clinical significance. PMID: 28107874 Ref: The CpG island methylator phenotype is concordant between primary colorectal carcinoma and matched distant metastases. PMID: 28469732 Ref: Effects of RUNX3 mediated Notch signaling pathway on biological characteristics of colorectal cancer cells. PMID: 28498402 Ref: CpG island methylator phenotype identifies high risk patients among microsatellite stable BRAF mutated colorectal cancers. PMID: 28542846 Ref: DNA methylation patterns in ulcerative colitis-associated cancer: a systematic review. PMID: 28621161 Ref: Screening of exon methylation biomarkers for colorectal cancer via LC-MS/MS strategy. PMID: 28940471 Ref: JAB1-STAT3 activation loop is associated with recurrence following 5-fluorouracil-based adjuvant chemotherapy in human colorectal cancer. PMID: 29113268 |
Ref: Genomic heterogeneity in primary colorectal carcinomas and their metastases: born bad or brought up a villain? PMID: 29307628 Ref: Epigenetic inactivation of RUNX3 in colorectal cancer. PMID: 29333422 Ref: CORRIGENDUM: Correction of funding statement in ACKNOWLEDGEMENTS section: Epigenetic inactivation of RUNX3 in colorectal cancer. PMID: 29521382 Ref: Oncogenic role of microRNA-532-5p in human colorectal cancer via targeting of the 5'UTR of RUNX3. PMID: 29849790 Ref: Prognostic Value of Methylator Phenotype in Stage III Colon Cancer Treated with Oxaliplatin-based Adjuvant Chemotherapy. PMID: 29921730 Ref: Lifestyle Factors, Colorectal Tumor Methylation, and Survival Among African Americans and European Americans. PMID: 29930328 Ref: Overexpression of miR-301a-3p promotes colorectal cancer cell proliferation and metastasis by targeting deleted in liver cancer-1 and runt-related transcription factor 3. PMID: 30362160 |