Primary Site >> Colorectal Cancer
Gene >> RRM2
| 1. | |||||||||||
| Journal: | Clin Cancer Res. 2001 Aug;7(8):2527-36. | ||||||||||
| Title: | Flavopiridol increases sensitization to gemcitabine in human gastrointestinal cancer cell lines and correlates with down-regulation of ribonucleotide reductase M2 subunit. | ||||||||||
| Author: | Jung, C P|Motwani, M V|Schwartz, G K | ||||||||||
| PMID: | 11489836 | ||||||||||
| 2. | |||||||||||
| Journal: | J Biol Chem. 2004 Jun 25;279(26):27030-8. | ||||||||||
| Title: | Stable suppression of the R2 subunit of ribonucleotide reductase by R2-targeted short interference RNA sensitizes p53(-/-) HCT-116 colon cancer cells to DNA-damaging agents and ribonucleotide reductase inhibitors. | ||||||||||
| Author: | Lin, Z Ping|Belcourt, Michael F|Cory, Joseph G|Sartorelli, Alan C | ||||||||||
| PMID: | 15096505 | ||||||||||
| 3. | |||||||||||
| Journal: | Clin Cancer Res. 2005 Apr 1;11(7):2612-9. | ||||||||||
| Title: | Variance in the expression of 5-Fluorouracil pathway genes in colorectal cancer. | ||||||||||
| Author: | Kidd, Elizabeth A|Yu, Jinsheng|Li, Xia|Shannon, William D|Watson, Mark A|McLeod, Howard L | ||||||||||
| PMID: | 15814641 | ||||||||||
| 4. | |||||||||||
| Journal: | World J Gastroenterol. 2005 Sep 7;11(33):5169-73. | ||||||||||
| Title: | Novel genetic variations of the p53R2 gene in patients with colorectal adenoma and controls. | ||||||||||
| Author: | Deng, Zong-Lin|Xie, Da-Wen|Bostick, Roberd M|Miao, Xi-Jiang|Gong, You-Ling|Zhang, Jin-Hui|Wargovich, Michael J | ||||||||||
| PMID: | 16127747 | ||||||||||
| 5. | |||||||||||
| Journal: | Cancer Res. 2005 Oct 15;65(20):9510-6. | ||||||||||
| Title: | In vivo induction of resistance to gemcitabine results in increased expression of ribonucleotide reductase subunit M1 as the major determinant. | ||||||||||
| Author: | Bergman, Andries M|Eijk, Paul P|Ruiz van Haperen, Veronique W T|Smid, Kees|Veerman, Gijsbert|Hubeek, Isabelle|van den Ijssel, Paul|Ylstra, Bauke|Peters, Godefridus J | ||||||||||
| PMID: | 16230416 | ||||||||||
| 6. | |||||||||||
| Journal: | Chemotherapy. 2006;52(1):20-2. | ||||||||||
| Title: | What is the best sequence of chemotherapy in advanced colorectal cancer? Final results of a five-arm study. | ||||||||||
| Author: | Popov, Ivan|Jelic, Svetislav|Krivokapic, Zoran|Micev, Marjan|Babic, Dragana|Zdrale, Zdravko | ||||||||||
| PMID: | 16340193 | ||||||||||
| 7. | |||||||||||
| Journal: | Cancer Res. 2006 Jul 1;66(13):6497-502. | ||||||||||
| Title: | Suppression of lung tumor formation by the regulatory subunit of ribonucleotide reductase. | ||||||||||
| Author: | Gautam, Ashish|Bepler, Gerold | ||||||||||
| PMID: | 16818620 | ||||||||||
| 8. | |||||||||||
| Journal: | Clin Colorectal Cancer. 2007 Jan;6(5):374-81. | ||||||||||
| Title: | Ribonucleotide reductase subunits M2 and p53R2 are potential biomarkers for metastasis of colon cancer. | ||||||||||
| Author: | Liu, Xiyong|Zhou, Bingsen|Xue, Lijun|Yen, Frank|Chu, Peiguo|Un, Frank|Yen, Yun | ||||||||||
| PMID: | 17311703 | ||||||||||
| 9. | |||||||||||
| Journal: | Oncol Rep. 2008 Jan;19(1):257-62. | ||||||||||
| Title: | Validation of biomarkers associated with 5-fluorouracil and thymidylate synthase in colorectal cancer. | ||||||||||
| Author: | Xi, Yaguang|Formentini, Andrea|Nakajima, Go|Kornmann, Marko|Ju, Jingfang | ||||||||||
| PMID: | 18097604 | ||||||||||
| 10. | |||||||||||
| Journal: | Int J Cancer. 2009 Nov 1;125(9):2086-94. | ||||||||||
| Title: | E2F4 and ribonucleotide reductase mediate S-phase arrest in colon cancer cells treated with chlorophyllin. | ||||||||||
| Author: | Chimploy, Korakod|Diaz, G Dario|Li, Qingjie|Carter, Orianna|Dashwood, Wan-Mohaiza|Mathews, Christopher K|Williams, David E|Bailey, George S|Dashwood, Roderick H | ||||||||||
| PMID: | 19585502 | ||||||||||
| 11. | |||||||||||
| Journal: | Int J Cancer. 2011 Mar 1;128(5):1069-79. | ||||||||||
| Title: | A genomic strategy for the functional validation of colorectal cancer genes identifies potential therapeutic targets. | ||||||||||
| Author: | Grade, Marian|Hummon, Amanda B|Camps, Jordi|Emons, Georg|Spitzner, Melanie|Gaedcke, Jochen|Hoermann, Patrick|Ebner, Reinhard|Becker, Heinz|Difilippantonio, Michael J|Ghadimi, B Michael|Beissbarth, Tim|Caplen, Natasha J|Ried, Thomas | ||||||||||
| PMID: | 20473941 | ||||||||||
| 12. | |||||||||||
| Journal: | Anticancer Res. 2011 Jul;31(7):2535-9. | ||||||||||
| Title: | KRAS-mediated up-regulation of RRM2 expression is essential for the proliferation of colorectal cancer cell lines. | ||||||||||
| Author: | Yoshida, Yasuhiro|Tsunoda, Toshiyuki|Doi, Keiko|Tanaka, Yoko|Fujimoto, Takahiro|Machida, Takashi|Ota, Takeharu|Koyanagi, Midori|Takashima, Yasuo|Sasazuki, Takehiko|Kuroki, Masahide|Iwasaki, Akinori|Shirasawa, Senji | ||||||||||
| PMID: | 21873171 | ||||||||||
| 13. | |||||||||||
| Journal: | World J Gastroenterol. 2012 Sep 14;18(34):4704-13. | ||||||||||
| Title: | Emerging roles of the ribonucleotide reductase M2 in colorectal cancer and ultraviolet-induced DNA damage repair. | ||||||||||
| Author: | Lu, Ai-Guo|Feng, Hao|Wang, Pu-Xiong-Zhi|Han, Ding-Pei|Chen, Xue-Hua|Zheng, Min-Hua | ||||||||||
| PMID: | 23002339 | ||||||||||
| 14. | |||||||||||
| Journal: | Mol Cancer Res. 2012 Jun;10(6):787-99. | ||||||||||
| Title: | SAP155-mediated splicing of FUSE-binding protein-interacting repressor serves as a molecular switch for c-myc gene expression. | ||||||||||
| Author: | Matsushita, Kazuyuki|Kajiwara, Toshiko|Tamura, Mai|Satoh, Mamoru|Tanaka, Nobuko|Tomonaga, Takeshi|Matsubara, Hisahiro|Shimada, Hideaki|Yoshimoto, Rei|Ito, Akihiro|Kubo, Shuji|Natsume, Tohru|Levens, David|Yoshida, Minoru|Nomura, Fumio | ||||||||||
| PMID: | 22496461 | ||||||||||
| 15. | |||||||||||
| Journal: | Clin Sci (Lond). 2013 May;124(9):567-78. | ||||||||||
| Title: | Ribonucleotide reductase small subunit M2 serves as a prognostic biomarker and predicts poor survival of colorectal cancers. | ||||||||||
| Author: | Liu, Xiyong|Zhang, Hang|Lai, Lily|Wang, Xiaochen|Loera, Sofia|Xue, Lijun|He, Huiyin|Zhang, Keqiang|Hu, Shuya|Huang, Yasheng|Nelson, Rebecca A|Zhou, Bingsen|Zhou, Lun|Chu, Peiguo|Zhang, Suzhan|Zheng, Shu|Yen, Yun | ||||||||||
| PMID: | 23113760 | ||||||||||
| 16. | |||||||||||
| Journal: | Gut Liver. 2014 Nov;8(6):662-8. | ||||||||||
| Title: | High expression of ribonucleotide reductase subunit M2 correlates with poor prognosis of hepatocellular carcinoma. | ||||||||||
| Author: | Lee, Boin|Ha, Sang Yun|Song, Dae Hyun|Lee, Hyun Woo|Cho, Soo Youn|Park, Cheol-Keun | ||||||||||
| PMID: | 25368754 | ||||||||||
| 17. | |||||||||||
| Journal: | Mol Ther Nucleic Acids. 2015 Jan 20;4:e221. | ||||||||||
| Title: | Molecular Properties, Functional Mechanisms, and Applications of Sliced siRNA. | ||||||||||
| Author: | Sun, Guihua|Yeh, Spencer Yele|Yuan, Christine Wan-Yin|Chiu, Margaret Jean-Yih|Yung, Bryan Shing Hei|Yen, Yun | ||||||||||
| PMID: | 25602583 | ||||||||||
| 18. | |||||||||||
| Journal: | Biochem Biophys Res Commun. 2015 Aug 21;464(2):407-15. | ||||||||||
| Title: | E2F1 promote the aggressiveness of human colorectal cancer by activating the ribonucleotide reductase small subunit M2. | ||||||||||
| Author: | Fang, Zejun|Gong, Chaoju|Liu, Hong|Zhang, Xiaomin|Mei, Lingming|Song, Mintao|Qiu, Lanlan|Luo, Shuchai|Zhu, Zhihua|Zhang, Ronghui|Gu, Hongqian|Chen, Xiang | ||||||||||
| PMID: | 26093293 | ||||||||||
| 19. | |||||||||||
| Journal: | Steroids. 2016 Jul;111:63-70. | ||||||||||
| Title: | The combination of tetraiodothyroacetic acid and cetuximab inhibits cell proliferation in colorectal cancers with different K-ras status. | ||||||||||
| Author: | Lee, Yee-Shin|Chin, Yu-Tang|Yang, Yu-Chen S H|Wei, Po-Li|Wu, Han-Chung|Shih, Ai|Lu, Yueh-Tong|Pedersen, Jens Z|Incerpi, Sandra|Liu, Leroy F|Lin, Hung-Yun|Davis, Paul J | ||||||||||
| PMID: | 26980146 | ||||||||||
| 20. | |||||||||||
| Journal: | Cell Death Discov. 2016 May 9;2:16027. | ||||||||||
| Title: | Repositioning of a cyclin-dependent kinase inhibitor GW8510 as a ribonucleotide reductase M2 inhibitor to treat human colorectal cancer. | ||||||||||
| Author: | Hsieh, Y-Y|Chou, C-J|Lo, H-L|Yang, P-M | ||||||||||
| PMID: | 27551518 | ||||||||||
| 21. | |||||||||||
| Journal: | BMC Cancer. 2016 Oct 12;16(1):795. | ||||||||||
| Title: | Molecular profile of 5-fluorouracil pathway genes in colorectal carcinoma. | ||||||||||
| Author: | Kunicka, T|Prochazka, P|Krus, I|Bendova, P|Protivova, M|Susova, S|Hlavac, V|Liska, V|Novak, P|Schneiderova, M|Pitule, P|Bruha, J|Vycital, O|Vodicka, P|Soucek, P | ||||||||||
| PMID: | 27733154 | ||||||||||
| 22. | |||||||||||
| Journal: | Oncotarget. 2016 Nov 22;7(47):78055-78068. | ||||||||||
| Title: | CREB1 directly activates the transcription of ribonucleotide reductase small subunit M2 and promotes the aggressiveness of human colorectal cancer. | ||||||||||
| Author: | Fang, Zejun|Lin, Aifen|Chen, Jiaoe|Zhang, Xiaomin|Liu, Hong|Li, Hongzhang|Hu, Yanyan|Zhang, Xia|Zhang, Jiangang|Qiu, Lanlan|Mei, Lingming|Shao, Jimin|Chen, Xiang | ||||||||||
| PMID: | 27801665 | ||||||||||
| 23. | |||||||||||
| Journal: | Exp Ther Med. 2017 Jul;14(1):338-343. | ||||||||||
| Title: | Next-generation sequencing reveals lymph node metastasis associated genetic markers in colorectal cancer. | ||||||||||
| Author: | Xie, Ni|Yao, Yujiang|Wan, Lili|Zhu, Ting|Liu, Litao|Yuan, Jianhui | ||||||||||
| PMID: | 28672935 | ||||||||||
| 24. | |||||||||||
| Journal: | Jpn J Radiol. 2017 Nov;35(11):664-672. | ||||||||||
| Title: | Involvement of miR-155/FOXO3a and miR-222/PTEN in acquired radioresistance of colorectal cancer cell line. | ||||||||||
| Author: | Khoshinani, Hamed Manoochehri|Afshar, Saeid|Pashaki, Abdolazim Sedighi|Mahdavinezhad, Ali|Nikzad, Safora|Najafi, Rezvan|Amini, Razieh|Gholami, Mohammad Hadi|Khoshghadam, Alireza|Saidijam, Massoud | ||||||||||
| PMID: | 28879560 | ||||||||||
| 25. | |||||||||||
| Journal: | Gut. 2017 Nov 7. pii: gutjnl-2017-314983. | ||||||||||
| Title: | SRSF6-regulated alternative splicing that promotes tumour progression offers a therapy target for colorectal cancer. | ||||||||||
| Author: | Wan, Ledong|Yu, Wenying|Shen, Enhui|Sun, Wenjie|Liu, Yuan|Kong, Jianlu|Wu, Yihua|Han, Fengyan|Zhang, Lei|Yu, Tianze|Zhou, Yuwei|Xie, Sunzhe|Xu, Enping|Zhang, Honghe|Lai, Maode | ||||||||||
| PMID: | 29114070 | ||||||||||
| 26. | |||||||||||
| Journal: | Oncol Lett. 2018 May;15(5):8107-8117. | ||||||||||
| Title: | miR-211 regulates the expression of RRM2 in tumoral metastasis and recurrence in colorectal cancer patients with a k-ras gene mutation. | ||||||||||
| Author: | Chang, Chiu-Chun|Lin, Chun-Che|Wang, Chia-Hung|Huang, Chi-Chou|Ke, Tao-Wei|Wei, Po-Li|Yeh, Ken-Tu|Hsu, Kai-Cheng|Hsu, Nan-Yung|Cheng, Ya-Wen | ||||||||||
| PMID: | 29731918 | ||||||||||
| 27. | |||||||||||
| Journal: | Horm Cancer. 2018 Oct;9(5):349-360. | ||||||||||
| Title: | Nano-Diamino-Tetrac (NDAT) Enhances Resveratrol-Induced Antiproliferation by Action on the RRM2 Pathway in Colorectal Cancers. | ||||||||||
| Author: | Nana, Andre Wendindonde|Wu, Szu Yuan|Yang, Yu-Chen Sh|Chin, Yu-Tang|Cheng, Tsai-Mu|Ho, Yih|Li, Wen-Shan|Liao, Yu-Min|Chen, Yi-Ru|Shih, Ya-Jung|Liu, Yun-Ru|Pedersen, Jens|Incerpi, Sandra|Hercbergs, Aleck|Liu, Leroy F|Whang-Peng, Jacqueline|Davis, Paul J|Li | ||||||||||
| PMID: | 30027502 | ||||||||||